Stephen McLaughlin

BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression

David Barras, Edoardo Missiaglia, Pratyaksha Wirapati, Oliver M Sieber, Robert N Jorissen, Chris Love, Peter L Molloy, Ian T Jones, Stephen McLaughlin, Peter Gibbs, Justin Guinney, Iris M Simon, Arnaud D Roth, Fred T Bosman, Sabine Tejpar, Mauro Delorenzi

Journal article  |  2017  |  CLINICAL CANCER RESEARCH

PURPOSE: Mutation of BRAF at the valine 600 residue occurs in approximately 10% of colorectal cancers, a group with particularly p..

Super-Selective Mesenteric Embolization Provides Effective Control of Lower GI Bleeding

Pham Toan, Anh Tran Bob, Kevin Ooi, Marcus Mykytowycz, Stephen McLaughlin, Matthew Croxford, Iain Skinner, Ian Faragher

Journal article  |  2017  |  RADIOLOGY RESEARCH AND PRACTICE

Introduction. We aimed to assess the efficacy and safety of digital subtraction angiography (DSA) and super-selective mesenteric a..

Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer

Robert N Jorissen, Michael Christie, Dmitri Mouradov, Anuratha Sakthianandeswaren, Shan Li, Christopher Love, Zheng-Zhou Xu, Peter L Molloy, Ian T Jones, Stephen McLaughlin, Robyn L Ward, Nicholas J Hawkins, Andrew R Ruszkiewicz, James Moore, Antony W Burgess, Dana Busam, Qi Zhao, Robert L Strausberg, Lara Lipton, Jayesh Desai, et al.

Journal article  |  2015  |  BRITISH JOURNAL OF CANCER

BACKGROUND: APC mutations (APC-mt) occur in ∼70% of colorectal cancers (CRCs), but their relationship to prognosis is unclear. MET..

Outcomes in the surgical treatment of low rectal cancer: does neoadjuvant treatment equalize results?

William G Pollett, Peter Gibbs, Stephen McLaughlin, Jimmy Eteuati, Michael Harold, Kaye Marion, Shweta Patel, Ian Jones

Journal article  |  2015  |  ANZ JOURNAL OF SURGERY

BACKGROUND: The choice of operation for potentially curable cancer of the low rectum (≤6 cm from the anal verge) is usually betwee..

Second primary colorectal cancer in the era of prevalent screening and imaging

Susie Bae, Muslim Asadi, Ian Jones, Stephen McLaughlin, Andrew Bui, Malcolm Steele, Jeanne Tie, Peter Gibbs

Journal article  |  2013  |  ANZ JOURNAL OF SURGERY

BACKGROUND: Oncology literature is increasingly recognizing prevalence of second primary cancers including several longitudinal st..

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations

Dmitri Mouradov, Enric Domingo, Peter Gibbs, Robert N Jorissen, Shan Li, Pik Ying Soo, Lara Lipton, Jayesh Desai, Havard E Danielsen, Dahmane Oukrif, Marco Novelli, Christopher Yau, Christopher C Holmes, Ian T Jones, Stephen McLaughlin, Peter Molloy, Nicholas J Hawkins, Robyn Ward, Rachel Midgely, David Kerr, et al.

Journal article  |  2013  |  AMERICAN JOURNAL OF GASTROENTEROLOGY

OBJECTIVES: Microsatellite instability (MSI) is an established marker of good prognosis in colorectal cancer (CRC). Chromosomal in..

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/beta-catenin signalling thresholds for tumourigenesis

M Christie, RN Jorissen, D Mouradov, A Sakthianandeswaren, S Li, F Day, C Tsui, L Lipton, J Desai, IT Jones, S McLaughlin, RL Ward, NJ Hawkins, AR Ruszkiewicz, J Moore, AW Burgess, D Busam, Q Zhao, RL Strausberg, AJ Simpson, et al.

Journal article  |  2013  |  ONCOGENE

Biallelic protein-truncating mutations in the adenomatous polyposis coli (APC) gene are prevalent in sporadic colorectal cancer (C..

PIK3CA and PTEN Gene and Exon Mutation-Specific Clinicopathologic and Molecular Associations in Colorectal Cancer

Fiona L Day, Robert N Jorissen, Lara Lipton, Dmitri Mouradov, Anuratha Sakthianandeswaren, Michael Christie, Shan Li, Cary Tsui, Jeannie Tie, Jayesh Desai, Zheng-Zhou Xu, Peter Molloy, Vicki Whitehall, Barbara A Leggett, Ian T Jones, Stephen McLaughlin, Robyn L Ward, Nicholas J Hawkins, Andrew R Ruszkiewicz, James Moore, et al.

Journal article  |  2013  |  CLINICAL CANCER RESEARCH

PURPOSE: PIK3CA and PTEN mutations are prevalent in colorectal cancer and potential markers of response to mitogen-activated prote..

Gastrointestinal: Omental infarction

J Ryan, P Simpson, S Mclaughlin

Journal article  |  2013  |  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer

Nicholas I Fleming, Robert N Jorissen, Dmitri Mouradov, Michael Christie, Anuratha Sakthianandeswaren, Michelle Palmieri, Fiona Day, Shan Li, Cary Tsui, Lara Lipton, Jayesh Desai, Ian T Jones, Stephen McLaughlin, Robyn L Ward, Nicholas J Hawkins, Andrew R Ruszkiewicz, James Moore, Hong-Jian Zhu, John M Mariadason, Antony W Burgess, et al.

Journal article  |  2013  |  CANCER RESEARCH

Activation of the canonical TGF-β signaling pathway provides growth inhibitory signals in the normal intestinal epithelium. Colore..