Mark Newton

Newly diagnosed seizures assessed at two established first seizure clinics: Clinic characteristics, investigations, and findings over 11 years

Anne M McIntosh, K Meng Tan, Tahir M Hakami, Mark R Newton, Patrick W Carney, Mengjiazhi Yang, Sibel Saya, David JT Marco, Piero Perucca, Patrick Kwan, Terence J O'Brien, Samuel F Berkovic

Journal article  |  2021  |  EPILEPSIA OPEN

OBJECTIVE: 'First seizure' clinics (FSCs) aim to achieve early expert assessment for individuals with possible new-onset epilepsy...

Long-term efficacy and safety of eslicarbazepine acetate monotherapy for adults with newly diagnosed focal epilepsy: An open-label extension study.

Eugen Trinka, Rodrigo Rocamora, João Chaves, Joana Moreira, Fábio Ikedo, Patrício Soares-da-Silva, undefined BIA-2093-311/EXT Investigators Study Group

Journal article  |  2020  |  Epilepsia

OBJECTIVE: To assess the efficacy, safety, and tolerability of eslicarbazepine acetate (ESL) monotherapy during long-term treatmen..

Blake's pouch cyst in 13q deletion syndrome: Posterior fossa malformations may occur due to disruption of multiple genes

Kenneth A Myers, Mathew J Wallis, Gregory J Fitt, Harvey B Sarnat, Mark R Newton

Journal article  |  2017  |  AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Familial Mesial Temporal Lobe Epilepsy and the Borderland of Deja Vu

Piero Perucca, Douglas E Crompton, Susannah T Bellows, Anne M McIntosh, Tomas Kalincik, Mark R Newton, Frank JE Vajda, Ingrid E Scheffer, Patrick Kwan, Terence J O'Brien, K Meng Tan, Samuel F Berkovic

Journal article  |  2017  |  ANNALS OF NEUROLOGY

OBJECTIVE: The cause of mesial temporal lobe epilepsy (MTLE) is often unknown. We ascertained to what extent newly diagnosed nonle..

Counselling adults who experience a first seizure.

Karen T Legg, Mark Newton

Journal article  |  2017  |  Seizure

PURPOSE: A first seizure can result in significant uncertainty, fear and apprehension. One of the key roles of the clinician in th..

A targeted resequencing gene panel for focal epilepsy

Michael S Hildebrand, Candace T Myers, Gemma L Carvill, Brigid M Regan, John A Damiano, Saul A Mullen, Mark R Newton, Umesh Nair, Elena V Gazina, Carol J Milligan, Christopher A Reid, Steven Petrou, Ingrid E Scheffer, Samuel F Berkovic, Heather C Mefford

Journal article  |  2016  |  NEUROLOGY

OBJECTIVES: We report development of a targeted resequencing gene panel for focal epilepsy, the most prevalent phenotypic group of..

Mind the gap: Multiple events and lengthy delays before presentation with a "first seizure"

Anna L Firkin, David JT Marco, Sibel Saya, Mark R Newton, Terence J O'Brien, Samuel F Berkovic, Anne M McIntosh

Journal article  |  2015  |  EPILEPSIA

OBJECTIVE: Up to half of patients assessed for suspected new-onset epileptic seizures report previous undiagnosed events. This sug..

Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies

Richard JL Anney, Andreja Avbersek, David Balding, Larry Baum, Felicitas Becker, Samuel F Berkovic, Jonathan P Bradfield, Lawrence C Brody, Russell J Buono, Claudia B Catarino, Gianpiero L Cavalleri, Stacey S Cherny, Krishna Chinthapalli, Alison J Coffey, Alastair Compston, Patrick Cossette, Gerrit-Jan de Haan, Peter De Jonghe, Carolien GF de Kovel, Norman Delanty, et al.

Journal article  |  2014  |  LANCET NEUROLOGY

BACKGROUND: The epilepsies are a clinically heterogeneous group of neurological disorders. Despite strong evidence for heritabilit..

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy

Doug Speed, Clive Hoggart, Slave Petrovski, Ioanna Tachmazidou, Alison Coffey, Andrea Jorgensen, Hariklia Eleftherohorinou, Maria De Iorio, Marian Todaro, Tisham De, David Smith, Philip E Smith, Margaret Jackson, Paul Cooper, Mark Kellett, Stephen Howell, Mark Newton, Raju Yerra, Meng Tan, Chris French, et al.

Journal article  |  2014  |  HUMAN MOLECULAR GENETICS

We present the analysis of a prospective multicentre study to investigate genetic effects on the prognosis of newly treated epilep..

Tonic seizures of Lennox-Gastaut syndrome: Periictal single-photon emission computed tomography suggests a corticopontine network

Utcharee Intusoma, David F Abbott, Richard AJ Masterton, Monique R Stagnitti, Mark R Newton, Graeme D Jackson, Jeremy L Freeman, A Simon Harvey, John S Archer

Journal article  |  2013  |  EPILEPSIA

PURPOSE: Lennox-Gastaut syndrome (LGS) is a severe epileptic disorder with characteristic electroclinical features but diverse eti..