Joe Smolich

Conduit arterial wave reflection promotes pressure transmission but impedes hydraulic energy transmission to the microvasculature

Avinash Kondiboyina, Joseph J Smolich, Michael MH Cheung, Berend E Westerhof, Jonathan P Mynard

Journal article  |  2020  |  American Journal of Physiology-Heart and Circulatory Physiology

Current thinking suggests that wave reflection in arteries limits pulse pressure and hydraulic energy (HE) transmission to the mic..

Accuracy of central blood pressure by Mobil-O-Graph in children and adolescents

Jonathan P Mynard, James E Sharman, Joseph J Smolich, Michael MH Cheung, Alberto Avolio

Journal article  |  2020  |  Journal of Hypertension

Central aortic blood pressure estimation in children and adolescents: results of the KidCoreBP study.

Jonathan P Mynard, Greta Goldsmith, Gabriella Springall, Lucas Eastaugh, Geoffrey K Lane, Diana Zannino, Joseph J Smolich, Alberto Avolio, Michael MH Cheung

Journal article  |  2020  |  Journal of Hypertension

BACKGROUND: Central aortic SBP (cSBP) may have superior prognostic value compared with peripheral SBP (pSBP), but noninvasive cSBP..

Brief asphyxial state following immediate cord clamping accelerates onset of left-to-right shunting across the ductus arteriosus after birth in preterm lambs

Joseph J Smolich, Kelly R Kenna, Michael MH Cheung, Jonathan P Mynard

Journal article  |  2020  |  Journal of Applied Physiology

Reversal of shunting across the ductus arteriosus from right-to-left to left-to-right is a characteristic feature of the birth tra..

Blunted sympathoadrenal activation accompanies hemodynamic stability after early ventilation and delayed cord clamping at birth in preterm lambs

Joseph J Smolich, Kelly R Kenna, Jonathan P Mynard, Sarah E Phillips, Gavin W Lambert

Journal article  |  2019  |  Pediatric Research

BACKGROUND: As surges in circulating norepinephrine and epinephrine have chronotropic, pressor, and inotropic effects, we tested t..

Antenatal betamethasone augments early rise in pulmonary perfusion at birth in preterm lambs: role of ductal shunting and right ventricular outflow distribution

Joseph J Smolich, Kelly R Kenna, Jonathan P Mynard

Journal article  |  2019  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Reduced Aortic Distensibility is Associated With Higher Aorto-Carotid Wave Transmission and Central Aortic Systolic Pressure in Young Adults After Coarctation Repair

Remi Kowalski, Melissa GY Lee, Lex W Doyle, Jeanie LY Cheong, Joseph J Smolich, Yves d'Udekem, Jonathan P Mynard, Michael MH Cheung

Journal article  |  2019  |  Journal of the American Heart Association

Background The long-term prognosis of patients with repaired aortic coarctation is characterized by high rates of cardiovascular a..

Assessment of single beat end-systolic elastance methods for quantifying ventricular contractility

Naomi Wo, Vijay Rajagopal, Michael MH Cheung, Joseph J Smolich, Jonathan P Mynard

Journal article  |  2019  |  Heart and Vessels

Multi-beat end-systolic elastance (EMB) is considered a gold-standard index of ventricular contractility. However, it is difficult..

Reducing lung liquid volume increases biventricular outputs and systemic arterial blood flows despite decreased cardiac filling pressures in fetal lambs

Joseph J Smolich, Jonathan P Mynard

Journal article  |  2019  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

As prior work has shown that reducing lung liquid volume 1) increases pulmonary arterial (PA) blood flow, 2) augments right ventri..

Comparison of invasive and non-invasive aortic wave intensity and wave power analyses in sheep

Remi Kowalski, Jonathan P Mynard, Joseph Smolich, Michael MH Cheung

Journal article  |  2019  |  Physiological Measurement

Noninvasive assessment of carotid arterial wave speed and distensibility

Jonathan P Mynard, Avinash Kondiboyina, Melanie M Clarke, Remi Kowalski, Michael MH Cheung, Joseph J Smolich

Journal article  |  2018  |  American Journal of Physiology-Heart and Circulatory Physiology

Increased right ventricular power and ductal characteristic impedance underpin higher pulmonary arterial blood flow after betamethasone therapy in fetal lambs

Joseph J Smolich, Jonathan P Mynard

Journal article  |  2018  |  Pediatric Research

Shifts in ovine cardiopulmonary microRNA expression in late gestation and the perinatal period

Ramona H Krauss, Belinda Phipson, Alicia Oshlack, Nikita Prasad-Gupta, Michael M Cheung, Joseph J Smolich, Salvatore Pepe

Journal article  |  2018  |  PLOS ONE

Increased aortic wave reflection contributes to higher systolic blood pressure in adolescents born preterm

Remi R Kowalski, Richard Beare, Jonathan P Mynard, Jeanie LY Cheong, Lex W Doyle, Joseph J Smolich, Michael MH Cheung

Journal article  |  2018  |  Journal of Hypertension

Major influence of a 'smoke and mirrors' effect caused by wave reflection on early diastolic coronary arterial wave intensity

Jonathan P Mynard, Daniel J Penny, Joseph J Smolich

Journal article  |  2018  |  The Journal of Physiology

Robust and practical non-invasive estimation of local arterial wave speed and mean blood velocity waveforms

Remi Kowalski, Richard Beare, Marie Willemet, Jordi Alastruey, Joseph J Smolich, Michael MH Cheung, Jonathan P Mynard

Journal article  |  2017  |  Physiological Measurement

COMMENTARY ON VIEWPOINT

Jonathan P Mynard, Joseph J Smolich

Journal article  |  2017  |  JOURNAL OF APPLIED PHYSIOLOGY

Wave potential: A unified model of arterial waves, reservoir phenomena and their interaction

Jonathan P Mynard, Joseph J Smolich

Journal article  |  2017  |  Artery Research

Greater sympathoadrenal activation with longer preventilation intervals after immediate cord clamping increases hemodynamic lability at birth in preterm lambs

Joseph J Smolich, Kelly R Kenna, Murray D Esler, Sarah E Phillips, Gavin W Lambert

Journal article  |  2017  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Beyond the aorta: partial transmission of reflected waves from aortic coarctation into supra-aortic branches modulates cerebral hemodynamics and left ventricular load

Jonathan P Mynard, Remi Kowalski, Michael MH Cheung, Joseph J Smolich

Journal article  |  2017  |  Biomechanics and Modeling in Mechanobiology

Major contribution of central pulmonary reservoir discharge to increased pulmonary arterial diastolic blood flow after birth in near-term lambs

Joseph J Smolich, Jonathan P Mynard

Journal article  |  2016  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Influence of anatomical dominance and hypertension on coronary conduit arterial and microcirculatory flow patterns: a multiscale modeling study

Jonathan P Mynard, Joseph J Smolich

Journal article  |  2016  |  American Journal of Physiology-Heart and Circulatory Physiology

Elevated Blood Pressure with Reduced Left Ventricular and Aortic Dimensions in Adolescents Born Extremely Preterm

Remi R Kowalski, Richard Beare, Lex W Doyle, Joseph J Smolich, Michael MH Cheung

Journal article  |  2016  |  The Journal of Pediatrics

Novel wave power analysis linking pressure-flow waves, wave potential, and the forward and backward components of hydraulic power

Jonathan P Mynard, Joseph J Smolich

Journal article  |  2016  |  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A step toward clinically applicable noninvasive coronary wave intensity analysis

Joseph J Smolich, Jonathan P Mynard

Journal article  |  2016  |  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Retrograde lower body arterial reservoir discharge underlies rapid reversal of ductus arteriosus shunting after early cord clamping at birth in preterm lambs

Joseph J Smolich, Kelly R Kenna, Jonathan P Mynard

Journal article  |  2016  |  JOURNAL OF APPLIED PHYSIOLOGY

Safety of Intracoronary Human Cord Blood Stem Cells in a Lamb Model of Infant Cardiopulmonary Bypass

Christian P Brizard, Jeffrey YJ Looi, Joseph J Smolich, Stephen B Horton, Julie Angerosa, Ngaire J Elwood, Salvatore Pepe

Journal article  |  2015  |  The Annals of Thoracic Surgery

One-Dimensional Haemodynamic Modeling and Wave Dynamics in the Entire Adult Circulation

Jonathan P Mynard, Joseph J Smolich

Journal article  |  2015  |  ANNALS OF BIOMEDICAL ENGINEERING

Onset of asphyxial state in nonrespiring interval between cord clamping and ventilation increases hemodynamic lability of birth transition in preterm lambs

Joseph J Smolich, Kelly R Kenna, Michael M Cheung

Journal article  |  2015  |  Journal of Applied Physiology

The ebbing tide of the reservoir-wave model

Jonathan P Mynard, Joseph J Smolich, Alberto Avolio

Journal article  |  2015  |  JOURNAL OF HYPERTENSION

The case against the reservoir-wave approach

Jonathan P Mynard, Joseph J Smolich

Journal article  |  2014  |  INTERNATIONAL JOURNAL OF CARDIOLOGY

Wave potential and the one-dimensional windkessel as a wave-based paradigm of diastolic arterial hemodynamics

Jonathan P Mynard, Joseph J Smolich

Journal article  |  2014  |  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Impact of levosimendan on brain injury patterns in a lamb model of infant cardiopulmonary bypass

Poongundran Namachivayam, Joseph J Smolich, Amy E Shields, Sandra Rees, Lee Coleman, Steven B Horton, Igor E Konstantinov, Daniel J Penny, Lara S Shekerdemian

Journal article  |  2014  |  Pediatric Research

Enhanced ventricular pump function and decreased reservoir backflow sustain rise in pulmonary blood flow after reduction of lung liquid volume in fetal lambs

Joseph J Smolich

Journal article  |  2014  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Scalability and in vivo validation of a multiscale numerical model of the left coronary circulation

Jonathan P Mynard, Daniel J Penny, Joseph J Smolich

Journal article  |  2014  |  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Wave reflection and central pressure augmentation

Jonathan P Mynard, Joseph J Smolich

Journal article  |  2013  |  JOURNAL OF HYPERTENSION

The reservoir-wave paradigm introduces error into arterial wave analysis: a computer modelling and in-vivo study (vol 30, pg 734, 2012)

JP Mynard, DJ Penny, MR Davidson, JJ Smolich

Journal article  |  2012  |  Journal of Hypertension

The reservoir-wave paradigm Reply

Jonathan P Mynard, Daniel J Penny, Malcolm R Davidson, Joseph J Smolich

Journal article  |  2012  |  Journal of Hypertension

Non-linear separation of pressure, velocity and wave intensity into forward and backward components

Jonathan P Mynard, Malcolm R Davidson, Daniel J Penny, Joseph J Smolich

Journal article  |  2012  |  MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

A simple, versatile valve model for use in lumped parameter and one-dimensional cardiovascular models

JP Mynard, MR Davidson, DJ Penny, JJ Smolich

Journal article  |  2012  |  International Journal for Numerical Methods in Biomedical Engineering

Increased right ventricular output and central pulmonary reservoir function support rise in pulmonary blood flow during adenosine infusion in the ovine fetus

Joseph J Smolich, Daniel J Penny, Jonathan P Mynard

Journal article  |  2012  |  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Tissue-specific splicing of an Ndufs6 gene-trap insertion generates a mitochondrial complex I deficiency-specific cardiomyopathy

Bi-Xia Ke, Salvatore Pepe, David R Grubb, Jasper C Komen, Adrienne Laskowski, Felicity A Rodda, Belinda M Hardman, James J Pitt, Michael T Ryan, Michael Lazarou, Jane Koleff, Michael MH Cheung, Joseph J Smolich, David R Thorburn

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

The reservoir-wave paradigm introduces error into arterial wave analysis: a computer modelling and in-vivo study

Jonathan P Mynard, Daniel J Penny, Malcolm R Davidson, Joseph J Smolich

Journal article  |  2012  |  JOURNAL OF HYPERTENSION

Enhanced central and conduit pulmonary arterial reservoir function offsets reduced ductal systolic outflow during constriction of the fetal ductus arteriosus

Joseph J Smolich, Daniel J Penny, Jonathan P Mynard

Journal article  |  2012  |  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Non-linear separation of pressure, velocity and wave intensity into forward and backward components.

JP Mynard, MR Davidson, DJ Penny, JJ Smolich

Journal article  |  2012  |  Medical & Biological Engineering & Computing

The reservoir-wave paradigm introduces error into arterial wave analysis: a computer modelling and in-vivo study

J MYNARD, DJ Penny, MR Davidson, JJ Smolich

Journal article  |  2012  |  Journal of Hypertension

MODELLING PRESSURE LOSSES AT ARTERIAL JUNCTIONS WITH APPLICATION TO JUNCTIONS OF THE FETAL DUCTUS ARTERIOSUS

Jonathan P Mynard, Malcolm R Davidson, Daniel J Penny, Joseph J Smolich

Conference Proceedings  |  2012  |  Proceedings of the ASME 2012 Summer Bioengineering Conference

Robustness of the P-U and lnD-U loop wave speed estimation methods: effects of the diastolic pressure decay and vessel wall non-linearities.

JP Mynard, MR Davidson, DJ Penny, JJ Smolich

Conference Proceedings  |  2011  |  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

Pulmonary trunk, ductus arteriosus, and pulmonary arterial phasic blood flow interactions during systole and diastole in the fetus

Joseph J Smolich, Jonathan P Mynard, Daniel J Penny

Journal article  |  2011  |  Journal of Applied Physiology

Robustness of the P-U and lnD-U loop wave speed estimation methods: Effects of the diastolic pressure decay and vessel wall non-linearities

Jonathan P Mynard, Malcolm R Davidson, Daniel J Penny, Joseph J Smolich

Conference Proceedings  |  2011  |  Proceedings the 33rd Annual International IEEE EMBC Conference

Wave intensity analysis of right ventricular and pulmonary vascular contributions to higher pulmonary than aortic blood pressure in fetal lambs

Joseph J Smolich, Jonathan P Mynard, Daniel J Penny

Journal article  |  2010  |  American Journal of Physiology - Heart and Circulatory Physiology

A numerical model of neonatal pulmonary atresia with intact ventricular septum and RV-dependent coronary flow

JP Mynard, MR Davidson, DJ Penny, JJ Smolich

Journal article  |  2010  |  International Journal for Numerical Methods in Biomedical Engineering

Urotensin-II Contributes to Pulmonary Vasoconstriction in a Perinatal Model of Persistent Pulmonary Hypertension of the Newborn Secondary to Meconium Aspiration Syndrome

Catherine M Simpson, Joseph J Smolich, Lara S Shekerdemian, Daniel J Penny

Journal article  |  2010  |  Pediatric Research

Ductus arteriosus wave intensity analysis in fetal lambs: midsystolic ductal flow augmentation is due to antegrade pulmonary arterial wave transmission

Joseph J Smolich, Jonathan P Mynard, Daniel J Penny

Journal article  |  2009  |  American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Dynamic characterization and hemodynamic effects of pulmonary waves in fetal lambs using cardiac extrasystoles and beat-by-beat wave intensity analysis

Joseph J Smolich, Jonathan P Mynard, Daniel J Penny

Journal article  |  2009  |  American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Wave intensity amplification and attenuation in non-linear flow: Implications for the calculation of local reflection coefficients

Jonathan Mynard, Daniel J Penny, Joseph J Smolich

Journal article  |  2008  |  Journal of Biomechanics

Accurate Automatic Detection of End-Diastole From Left Ventricular Pressure Using Peak Curvature

Jonathan P Mynard, Daniel J Penny, Joseph J Smolich

Journal article  |  2008  |  Biomedical Engineering: Applications, Basis and Communications

Simultaneous pulmonary trunk and pulmonary arterial wave intensity analysis in fetal lambs: evidence for cyclical, midsystolic pulmonary vasoconstriction

Joseph J Smolich, Jonathan P Mynard, Daniel J Penny

Journal article  |  2008  |  American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

The physiological basis of a characteristically low blood flow to the fetal lungs is incompletely understood. To determine the pot..

Aortic wave intensity analysis of ventricular-vascular interaction during incremental dobutamine infusion in adult sheep

Daniel J Penny, Jonathan P Mynard, Joseph J Smolich

Journal article  |  2008  |  American Journal of Physiology - Heart and Circulatory Physiology

A semi-automatic feature detection algorithm for hemodynamic signals using curvature-based feature extraction

Jonathan P Mynard, Daniel J Penny, Joseph J Smolich

Conference Proceedings  |  2007  |  Proceedings of the 29th Annual International Conference of the IEEE EMBS