Joe Smolich

Milrinone Acts as a Vasodilator But Not an Inotrope in Children After Cardiac Surgery-Insights From Wave Intensity Analysis

Sarfaraz Rahiman, Remi Kowalski, Sit Yee Kwok, Sunit Matha, Bryn Jones, Joseph J Smolich, Jonathan P Mynard, Warwick Butt, Johnny Millar

Journal article  |  2020  |  CRITICAL CARE MEDICINE

OBJECTIVES: Milrinone is an inodilator widely used in the postoperative management of children undergoing cardiac surgery. The lit..

Measurement, Analysis and Interpretation of Pressure/Flow Waves in Blood Vessels

Jonathan P Mynard, Avinash Kondiboyina, Remi Kowalski, Michael MH Cheung, Joseph J Smolich

Journal article  |  2020  |  FRONTIERS IN PHYSIOLOGY

The optimal performance of the cardiovascular system, as well as the break-down of this performance with disease, both involve com..

Conduit arterial wave reflection promotes pressure transmission but impedes hydraulic energy transmission to the microvasculature

Avinash Kondiboyina, Joseph J Smolich, Michael MH Cheung, Berend E Westerhof, Jonathan P Mynard

Journal article  |  2020  |  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Current thinking suggests that wave reflection in arteries limits pulse pressure and hydraulic energy (HE) transmission to the mic..

Accuracy of central blood pressure by Mobil-O-Graph in children and adolescents

Jonathan P Mynard, James E Sharman, Joseph J Smolich, Michael MH Cheung, Alberto Avolio

Journal article  |  2020  |  JOURNAL OF HYPERTENSION

Minor impact of constraint from perivascular flow probes on wave intensity analysis

Jonathan P Mynard, Joseph J Smolich

Journal article  |  2020  |  PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE

Perivascular flow probes are considered the gold-standard for measuring volumetric blood flow in animal studies. Although flow pro..

Central aortic blood pressure estimation in children and adolescents: results of the KidCoreBP study

Jonathan P Mynard, Greta Goldsmith, Gabriella Springall, Lucas Eastaugh, Geoffrey K Lane, Diana Zannino, Joseph J Smolich, Alberto Avolio, Michael MH Cheung

Journal article  |  2020  |  JOURNAL OF HYPERTENSION

BACKGROUND: Central aortic SBP (cSBP) may have superior prognostic value compared with peripheral SBP (pSBP), but noninvasive cSBP..

Brief asphyxial state following immediate cord clamping accelerates onset of left-to-right shunting across the ductus arteriosus after birth in preterm lambs

Joseph J Smolich, Kelly R Kenna, Michael MH Cheung, Jonathan P Mynard

Journal article  |  2020  |  JOURNAL OF APPLIED PHYSIOLOGY

Reversal of shunting across the ductus arteriosus from right-to-left to left-to-right is a characteristic feature of the birth tra..

Blunted sympathoadrenal activation accompanies hemodynamic stability after early ventilation and delayed cord clamping at birth in preterm lambs

Joseph J Smolich, Kelly R Kenna, Jonathan P Mynard, Sarah E Phillips, Gavin W Lambert

Journal article  |  2019  |  PEDIATRIC RESEARCH

BACKGROUND: As surges in circulating norepinephrine and epinephrine have chronotropic, pressor, and inotropic effects, we tested t..

Antenatal betamethasone augments early rise in pulmonary perfusion at birth in preterm lambs: role of ductal shunting and right ventricular outflow distribution

Joseph J Smolich, Kelly R Kenna, Jonathan P Mynard

Journal article  |  2019  |  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The glucocorticosteroid betamethasone is routinely administered via maternal intramuscular injection to enhance fetal lung maturat..

Reduced Aortic Distensibility is Associated With Higher Aorto-Carotid Wave Transmission and Central Aortic Systolic Pressure in Young Adults After Coarctation Repair

Remi Kowalski, Melissa GY Lee, Lex W Doyle, Jeanie LY Cheong, Joseph J Smolich, Yves d'Udekem, Jonathan P Mynard, Michael MH Cheung

Journal article  |  2019  |  JOURNAL OF THE AMERICAN HEART ASSOCIATION

Background The long-term prognosis of patients with repaired aortic coarctation is characterized by high rates of cardiovascular a..