Jarny Choi is a postdoctoral fellow at the University of Melbourne Centre for Stem Cell Systems (CSCS). He is an experienced bioinformatician, working towards better understanding of cellular origins and differentiation, especially within the field of haematopoieisis and stem cells.
He possesses a wide range of cross-disciplinary skills, with many years of experience in genomics data analysis and development of online tools.
Jarny obtained a PhD in theoretical physics at the University of Melbourne, focusing on the matter-antimatter asymmetry of the universe as the main topic. After several years working as a systems developer amongst other work, he moved into bioinformatics working at the Walter and Eliza Hall Institute. There he developed several genomics data analysis tools, including haemosphere.org. He was also heavily involved in the drug target discovery program in collaboration with CSL (Commonwealth Serum Laboratories).
Currently at CSCS, Jarny is focusing on building a "Blood Atlas" within the stemformatics.org framework, analysing gene expression data from haematopoietic cell types to enhance our understanding of blood cells differentiation, leukaemia and bone marrow niche. He also develops data visualisation tools, including those for analysis of single cell RNA-seq data.
Find out more about Jarny Choi's experience
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Jarny Choi's selected work
Transcriptional Profiling of Stem Cells: Moving from Descriptive to Predictive Paradigms
iMAC: An interactive atlas to explore phenotypic differences between in vivo, ex vivo and ..
Displaying the 2 most recent projects by Jarny Choi.
Displaying the 13 most recent scholarly works by Jarny Choi.
A simple, scalable approach to building a cross-platform transcriptome atlas
Paul Angel, Nadia Rajab, Yidi Deng, Chris Pacheco, Tyrone Chen, Kim-Anh Lê Cao, Jarny Choi, Christine Wells
Journal article | 2020
ABSTRACT Gene expression atlases have transformed our understanding of the development, composition and function of human tissues...
HBO1 is required for the maintenance of leukaemia stem cells
Laura MacPherson, Juliana Anokye, Miriam M Yeung, Enid YN Lam, Yih-Chih Chan, Chen-Fang Weng, Paul Yeh, Kathy Knezevic, Miriam S Butler, Annabelle Hoegl, Kah-Lok Chan, Marian L Burr, Linden J Gearing, Tracy Willson, Joy Liu, Jarny Choi, Yuqing Yang, Rebecca A Bilardi, Hendrik Falk, Nghi Nguyen, et al.
Journal article | 2020 | Nature
Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in..
iMAC: An interactive atlas to explore phenotypic differences between in vivo, ex vivo and in vitro-derived myeloid cells in the Stemformatics platform
Nadia Rajab, Paul Angel, Mariola Kurowska-Stolarska, Simon Milling, Chris Pacheco, Matt Rutar, Jarny Choi, Christine Wells
Journal article | 2019
Summary Macrophages isolated from different tissues have distinct niche roles that maintain tissue homeostasis, as well as providi..
TCF-1 limits the formation of Tc17 cells via repression of the MAF-ROR gamma t axis
Lisa A Mielke, Yang Liao, Ella Bridie Clemens, Matthew A Firth, Brigette Duckworth, Qiutong Huang, Francisca F Almeida, Michael Chopin, Hui-Fern Koay, Carolyn A Bell, Soroor Hediyeh-Zadeh, Simone L Park, Dinesh Raghu, Jarny Choi, Tracy L Putoczki, Philip D Hodgkin, Ashley E Franks, Laura K Mackay, Dale Godfrey, Melissa J Davis, et al.
Journal article | 2019 | Journal of Experimental Medicine
Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans
Jarny Choi, Tracey M Baldwin, Mae Wong, Jessica E Bolden, Kirsten A Fairfax, Erin C Lucas, Rebecca Cole, Christine Biben, Clare Morgan, Kerry A Ramsay, Ashley P Ng, Maria Kauppi, Lynn M Corcoran, Wei Shi, Nick Wilson, Michael J Wilson, Warren S Alexander, Douglas J Hilton, Carolyn A de Graaf
Journal article | 2019 | Nucleic Acids Research
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias
Shahzya Chaudhury, Caitriona O'Connor, Ana Canete, Joana Bittencourt-Silvestre, Evgenia Sarrou, Aine Prendergast, Jarny Choi, Pamela Johnston, Christine A Wells, Brenda Gibson, Karen Keeshan
Journal article | 2018 | Nature Communications
Haemopedia: An Expression Atlas of Murine Hematopoietic Cells
Carolyn A De Graaf, Jarny Choi, Tracey M Baldwin, Jessica E Bolden, Kirsten A Fairfax, Aaron J Robinson, Christine Biben, Clare Morgan, Kerry Ramsay, Ashley P Ng, Maria Kauppi, Elizabeth A Kruse, Tobias J Sargeant, Nick Seidenman, Angela D'Amico, Marthe C D'Ombrain, Erin C Lucas, Sandra Koernig, Adriana Baz Morelli, Michael J Wilson, et al.
Journal article | 2016 | Stem Cell Reports
UNDERSTANDING THE MOLECULAR REGULATION OF EOSINOPHIL PRODUCTION: A BASIS FOR INTERVENTION IN INFLAMMATORY DISEASE
Clare Morgan, Tracey Baldwin, Marthe D'Ombrain, Carolyn de Graaf, Jarny Choi, Aaron Robinson, Kerry Ramsay, Don Metcalf, Warren Alexander, Douglas Hilton
Conference Proceedings | 2014 | Experimental Hematology
Anatomy And Neuroscience
Australian Bioinformatics and Computational Biology Society
Doctor of Philosophy
University of Melbourne