Dorothy Machalek

parC Variants in Mycoplasma genitalium: Trends over Time and Association with Moxifloxacin Failure

Gerald L Murray, Kaveesha Bodiyabadu, Lenka A Vodstrcil, Dorothy A Machalek, Jennifer Danielewski, Erica L Plummer, Suzanne M Garland, David M Whiley, Emma L Sweeney, Catriona S Bradshaw

Journal article  |  2022  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prevalence, trends, and treatment outcome estimates were generated for parC variants in macrolide-resistant Mycoplasma genitalium...

Impact of 16S rRNA Single Nucleotide Polymorphisms on Mycoplasma genitalium Organism Load with Doxycycline Treatment

Teck-Phui Chua, Jennifer Danielewski, Kaveesha Bodiyabadu, Catriona S Bradshaw, Dorothy A Machalek, Suzanne M Garland, Erica L Plummer, Lenka A Vodstrcil, Gerald L Murray

Journal article  |  2022  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Doxycycline targets the 16S rRNA and is widely used for the treatment of sexually transmitted infections. While it is not highly e..

Gene methylation of CADM1 and MAL identified as a biomarker of high grade anal intraepithelial neoplasia

Samuel Phillips, Kahli Cassells, Suzanne M Garland, Dorothy A Machalek, Jennifer M Roberts, David J Templeton, Fengyi Jin, I Mary Poynten, Richard J Hillman, Andrew E Grulich, Gerald L Murray, Sepehr N Tabrizi, Monica Molano, Alyssa M Cornall

Journal article  |  2022  |  SCIENTIFIC REPORTS

Human papillomavirus (HPV) is detected in up to 96% of anal squamous cell cancers, where screening programs needed. However, the b..

Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibodies in Australia After the First Epidemic Wave in 2020: A National Survey.

Kaitlyn M Vette, Dorothy A Machalek, Heather F Gidding, Suellen Nicholson, Matthew VN O'Sullivan, John B Carlin, Marnie Downes, Lucy Armstrong, Frank H Beard, Dominic E Dwyer, Robert Gibb, Iain B Gosbell, Alexandra J Hendry, Geoff Higgins, Rena Hirani, Linda Hueston, David O Irving, Helen E Quinn, Hannah Shilling, David Smith, et al.

Journal article  |  2022  |  Open Forum Infect Dis

BACKGROUND: As of mid-2021, Australia's only nationwide coronavirus disease 2019 (COVID-19) epidemic occurred in the first 6 month..

Effect on genital warts in Australian female and heterosexual male individuals after introduction of the national human papillomavirus gender-neutral vaccination programme: an analysis of national sentinel surveillance data from

Eric PF Chow, Allison Carter, Tobias Vickers, Christopher K Fairley, Anna McNulty, Rebecca J Guy, David G Regan, Andrew E Grulich, Denton Callander, Laila Khawar, Dorothy A Machalek, Basil Donovan

Journal article  |  2021  |  LANCET INFECTIOUS DISEASES

BACKGROUND: In Australia, the government-funded human papillomavirus (HPV) vaccination programme was introduced in April, 2007, fo..

Prevalence of human papillomavirus in young men who have sex with men after the implementation of gender-neutral HPV vaccination: a repeated cross-sectional study

Eric PF Chow, Sepehr N Tabrizi, Christopher K Fairley, Rebecca Wigan, Dorothy A Machalek, Suzanne M Garland, Alyssa M Cornall, Steph Atchison, Jane S Hocking, Catriona S Bradshaw, Prisha Balgovind, Gerald L Murray, Marcus Y Chen

Journal article  |  2021  |  LANCET INFECTIOUS DISEASES

BACKGROUND: Anal infection with high-risk human papillomavirus (HPV) genotypes 16 and 18 and anal cancer are overrepresented in me..

Genital warts trends in Australian and overseas-born people in Australia: A cross-sectional trend analysis to measure progress towards control and elimination

Laila Khawar, Hamish McManus, Tobias Vickers, Eric PF Chow, Christopher K Fairley, Basil Donovan, Dorothy A Machalek, David G Regan, Andrew E Grulich, Rebecca J Guy, Skye McGregor

Journal article  |  2021  |  LANCET REGIONAL HEALTH-WESTERN PACIFIC

Background: Substantial declines in genital warts have been observed in countries with quadrivalent/nonavalent human papillomaviru..

Human papillomavirus prevalence and risk factors among Australian women 9-12 years after vaccine program introduction

Hannah Shilling, Suzanne M Garland, Steph Atchison, Alyssa M Cornall, Julia ML Brotherton, Deborah Bateson, Kathleen McNamee, John M Kaldor, Jane S Hocking, Marcus Y Chen, Christopher K Fairley, Anna McNulty, Charlotte Bell, Lewis Marshall, Catriona Ooi, S Rachel Skinner, Gerald Murray, Monica Molano, Sepehr Tabrizi, Dorothy A Machalek

Journal article  |  2021  |  VACCINE

BACKGROUND: In Australia, high and widespread uptake of the quadrivalent human papillomavirus (HPV) vaccine has led to substantial..

Evaluation of the Roche MagNA Pure 96 nucleic acid extraction platform for the Seegene Anyplex II HPV28 detection assay

S Atchison, H Shilling, P Balgovind, DA Machalek, D Hawkes, SM Garland, M Saville, G Murray, M Molano, J Danielewski, S Phillips

Journal article  |  2021  |  JOURNAL OF APPLIED MICROBIOLOGY

AIM: Validate the Roche, MagNAPure96 (MP96) nucleic acid extraction platform for Seegene Anyplex II HPV28 (Anyplex28) detection of..

Chlamydia trachomatis and Mycoplasma genitalium prevalence and associated factors among women presenting to a pregnancy termination and contraception clinic, 2009-2019

Hannah S Shilling, Suzanne M Garland, Anna-Maria Costa, Alex Marceglia, Katherine Fethers, Jennifer Danielewski, Gerald Murray, Catriona Bradshaw, Lenka Vodstrcil, Jane S Hocking, John Kaldor, Rebecca Guy, Dorothy A Machalek

Journal article  |  2021  |  SEXUALLY TRANSMITTED INFECTIONS

BACKGROUND: Risk of pelvic inflammatory disease associated with Chlamydia trachomatis and Mycoplasma genitalium is increased after..