Zhanqi Liu

Global conformational changes in IgG-Fc upon mutation of the FcRn-binding site are not associated with altered antibody-dependent effector functions

Ingrid JG Burvenich, William Farrugia, Zhanqi Liu, Dahna Makris, Dylan King, Benjamin Gloria, Angelo Perani, Laura C Allan, Andrew M Scott, Paul A Ramsland

Journal article  |  2018  |  BIOCHEMICAL JOURNAL

Antibody engineering is important for many diagnostic and clinical applications of monoclonal antibodies. We recently reported a s..

Molecular imaging of T cell co-regulator factor B7-H3 with Zr-89-DS-5573a

Ingrid Julienne Georgette Burvenich, Sagun Parakh, Fook-Thean Lee, Nancy Guo, Zhanqi Liu, Hui Kong Gan, Angela Rigopoulos, Graeme Joseph O'Keefe, Sylvia Jie Gong, Yit Wooi Goh, Henri Tochon-Danguy, Fiona Elizabeth Scott, Masakatsu Kotsuma, Kenji Hirotani, Giorgio Senaldi, Andrew Mark Scott

Journal article  |  2018  |  THERANOSTICS

An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth

Lakmali Atapattu, Nayanendu Saha, Chanly Chheang, Moritz F Eissman, Kai Xu, Mary E Vail, Linda Hii, Carmen Llerena, Zhanqi Liu, Katja Horvay, Helen E Abud, Ulrike Kusebauch, Robert L Moritz, Bi-Sen Ding, Zhongwei Cao, Shahin Rafii, Matthias Ernst, Andrew M Scott, Dimitar B Nikolov, Martin Lackmann, et al.

Journal article  |  2016  |  JOURNAL OF EXPERIMENTAL MEDICINE

The transmembrane metalloprotease ADAM10 sheds a range of cell surface proteins, including ligands and receptors of the Notch, Eph..

L-Tyrosine Confers Residualizing Properties to a D-Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies

Fook T Lee, Ingrid JG Burvenich, Nancy Guo, Pece Kocovski, Henri Tochon-Danguy, Uwe Ackermann, Graeme J O'Keefe, Sylvia Gong, Angela Rigopoulos, Zhanqi Liu, Hui K Gan, Andrew M Scott

Journal article  |  2016  |  MOLECULAR IMAGING

PURPOSE: The aims of the study were to develop and evaluate a novel residualizing peptide for labeling internalizing antibodies wi..

Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers

Ingrid JG Burvenich, Fook-Thean Lee, Graeme J O'Keefe, Dahna Makris, Diana Cao, Sylvia Gong, Angela Rigopoulos, Laura C Allan, Martin W Brechbiel, Zhanqi Liu, Paul A Ramsland, Andrew M Scott

Journal article  |  2016  |  EJNMMI RESEARCH

BACKGROUND: The aim of the study was to explore Fc mutations of a humanised anti-Lewis-Y antibody (IgG1) hu3S193 as a strategy to ..

Cross-species analysis of Fc engineered anti-Lewis-Y human IgG1 variants in human neonatal receptor transgenic mice reveal importance of S254 and Y436 in binding human neonatal Fc receptor

Ingrid JG Burvenich, William Farrugia, Fook T Lee, Bruno Catimel, Zhanqi Liu, Dahna Makris, Diana Cao, Graeme J O'Keefe, Martin W Brechbiel, Dylan King, Violeta Spirkoska, Laura C Allan, Paul A Ramsland, Andrew M Scott

Journal article  |  2016  |  MABS

IgG has a long half-life through engagement of its Fc region with the neonatal Fc receptor (FcRn). The FcRn binding site on IgG1 h..

A pilot study of monoclonal antibody cG250 and low dose subcutaneous IL-2 in patients with advanced renal cell carcinoma.

Ian D Davis, Zhanqi Liu, Wayne Saunders, Fook-Thean Lee, Violeta Spirkoska, Wendie Hopkins, Fiona E Smyth, Geoffrey Chong, Anthony T Papenfuss, Bridget Chappell, Aurora Poon, Timothy H Saunder, Eric W Hoffman, Lloyd J Old, Andrew M Scott

Journal article  |  2007  |  Cancer Immun

The chimeric monoclonal antibody cG250 recognizes the CAIX/MN antigen. cG250 induces antibody-dependent cellular cytotoxicity (ADC..