Irina Caminschi

Complexing CpG adjuvants with cationic liposomes enhances vaccine-induced formation of liver TRM cells.

Ana Maria Valencia-Hernandez, Thomas Zillinger, Zhengyu Ge, Peck S Tan, Anton Cozijnsen, Geoffrey I McFadden, Mireille H Lahoud, Irina Caminschi, Winfried Barchet, William R Heath, Daniel Fernandez-Ruiz

Journal article  |  2023  |  Vaccine

Tissue resident memory T cells (TRM cells) can provide effective tissue surveillance and can respond rapidly to infection. Vaccina..

The dendritic cell receptor Clec9A: receptor regulation and immune modulation

Kirsteen M Tullett, Peck Szee Tan, Hae-Young Park, Ralf B Schittenhelm, Nicole Michael, Marnie Blewitt, Irina Caminschi, Ken Shortman, Anthony W Purcell, Nicos Nicola, Jian-Guo Zhang, Mireille H Lahoud

Journal article  |  2022  |  Molecular Immunology

Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86

Haiyin Liu, Kayla R Wilson, Ashley M Firth, Christophe Macri, Patrick Schriek, Annabelle B Blum, Javiera Villar, Samuel Wormald, Mitch Shambrook, Bangyan Xu, Hui Jing Lim, Hamish EG McWilliam, Andrew F Hill, Laura E Edgington-Mitchell, Irina Caminschi, Mireille H Lahoud, Elodie Segura, Marco J Herold, Jose A Villadangos, Justine D Mintern

Journal article  |  2022  |  NATURE COMMUNICATIONS

The MARCH E3 ubiquitin (Ub) ligase MARCH1 regulates trafficking of major histocompatibility complex class II (MHC II) and CD86, mo..

Marginal zone B cells acquire dendritic cell functions by trogocytosis

Patrick Schriek, Alan C Ching, Nagaraj S Moily, Jessica Moffat, Lynette Beattie, Thiago M Steiner, Laine M Hosking, Joshua M Thurman, V Michael Holers, Satoshi Ishido, Mireille H Lahoud, Irina Caminschi, William R Heath, Justine D Mintern, Jose A Villadangos

Journal article  |  2022  |  SCIENCE

Marginal zone (MZ) B cells produce broad-spectrum antibodies that protect against infection early in life. In some instances, anti..

Splenic Dendritic Cells and Macrophages Drive B Cells to Adopt a Plasmablast Cell Fate.

Hayley A McNamara, Mireille H Lahoud, Yeping Cai, Jessica Durrant-Whyte, James H O'Connor, Irina Caminschi, Ian A Cockburn

Journal article  |  2022  |  Front Immunol

Upon encountering cognate antigen, B cells can differentiate into short-lived plasmablasts, early memory B cells or germinal cente..

The unexpected contribution of conventional type 1 dendritic cells in driving antibody responses

Thiago M Steiner, William R Heath, Irina Caminschi

Journal article  |  2021  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Antibodies are hallmarks of most effective vaccines. For successful T-dependent antibody responses, conventional dendritic cells (..

MHC Class II Ubiquitination Regulates Dendritic Cell Function and Immunity

Kayla R Wilson, Devi Jenika, Annabelle B Blum, Christophe Macri, Bangyan Xu, Haiyin Liu, Patrick Schriek, Dominik Schienstock, Lauren Francis, F Victor Makota, Satoshi Ishido, Scott N Mueller, Mireille H Lahoud, Irina Caminschi, Laura E Edgington-Mitchell, Jose A Villadangos, Justine D Mintern

Journal article  |  2021  |  JOURNAL OF IMMUNOLOGY

MHC class II (MHC II) Ag presentation by dendritic cells (DCs) is critical for CD4+ T cell immunity. Cell surface levels of MHC II..

Elucidating the Motif for CpG Oligonucleotide Binding to the Dendritic Cell Receptor DEC-205 Leads to Improved Adjuvants for Liver-Resident Memory

Jessica Li, Fatma Panetta, Meredith O'Keeffe, Ingrid M Leal Rojas, Kristen J Radford, Jian-Guo Zhang, Daniel Fernandez-Ruiz, Gayle M Davey, Benjamin S Gully, Kirsteen M Tullett, Jamie Rossjohn, Richard Berry, Chin-Nien Lee, Mireille H Lahoud, William R Heath, Irina Caminschi

Journal article  |  2021  |  JOURNAL OF IMMUNOLOGY

DEC-205 is a cell-surface receptor that transports bound ligands into the endocytic pathway for degradation or release within lyso..

Liver resident CD4 T cells in malaria infection

Matthias H Enders, Lynette Beattie, Anton Cozsijnsen, Irina Caminschi, Geoffreey I Mc Fadden, Elvira Mass, Daniel Ferndandez Ruiz, William R Heath

Conference Proceedings  |  2021  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Plasmodium berghei Hsp90 contains a natural immunogenic I-Ab-restricted antigen common to rodent and human Plasmodium species.

Matthias H Enders, Ganchimeg Bayarsaikhan, Sonia Ghilas, Yu Cheng Chua, Rose May, Maria N de Menezes, Zhengyu Ge, Peck Szee Tan, Anton Cozijnsen, Vanessa Mollard, Katsuyuki Yui, Geoffrey I McFadden, Mireille H Lahoud, Irina Caminschi, Anthony W Purcell, Ralf B Schittenhelm, Lynette Beattie, William R Heath, Daniel Fernandez-Ruiz

Journal article  |  2021  |  Curr Res Immunol

Thorough understanding of the role of CD4 T cells in immunity can be greatly assisted by the study of responses to defined specifi..