Jayesh Desai

Phase I, Open-Label, Dose-Escalation/Dose-Expansion Study of Lifirafenib (BGB-283), an RAF Family Kinase Inhibitor, in Patients With Solid Tumors.

Jayesh Desai, Hui Gan, Catherine Barrow, Michael Jameson, Victoria Atkinson, Andrew Haydon, Michael Millward, Stephen Begbie, Michael Brown, Ben Markman, William Patterson, Andrew Hill, Lisa Horvath, Adnan Nagrial, Gary Richardson, Christopher Jackson, Michael Friedlander, Phillip Parente, Ben Tran, Lai Wang, et al.

Journal article  |  2020  |  Journal of Clinical Oncology

PURPOSE: Lifirafenib is an investigational, reversible inhibitor of B-RAFV600E, wild-type A-RAF, B-RAF, C-RAF, and EGFR. This firs..

Cost-effectiveness analysis of imaging surveillance in stage II and III extremity soft tissue sarcoma: an Australian perspective

Susie Bae, Jonathan Karnon, Glenis Crane, Taryn Bessen, Jayesh Desai, Phillip Crowe, Susan Neuhaus

Journal article  |  2020  |  Cost Effectiveness and Resource Allocation

Beacon Crc: a Randomized, Phase 3 Study of Encorafenib (ENCO) and Cetuximab (CETUX) with or without Binimetinib (BiNI) vs. Choice of Either Irinotecan or Folfiri Plus Cetux in BRAF V600E-Mutant Metastatic Colorectal Cancer (mCRC)

Arndt Vogel, Susanna Hegewisch-Becker, Gerald Prager, Gunnar Folprecht, Michael Stahl, Scott Kopetz, Axel Grothey, Eric van Cutsetn, Rona Yaeger, Harpreet Wasan, Takayuki Yoshino, Jayesh Desai, Fortunato Ciardello, Ashwin Gollerkeri, Kati Maharry, Fotios Loupakis, Y Hong, Neeltje Steeghs, Tormod Kyrre Guren, Hendrik-Tobias Arkenau, et al.

Conference Proceedings  |  2020  |  ONCOLOGY RESEARCH AND TREATMENT

Encorafenib plus cetuximab with or without binimetinib for BRAF V600E-mutant metastatic colorectal cancer: Quality-of-life results from a randomized, three-arm, phase III study versus the choice of either irinotecan or FOLFIRI plus cetuximab (BEACON CRC).

Scott Kopetz, Axel Grothey, Eric Van Cutsem, Rona Yaeger, Harpreet Singh Wasan, Takayuki Yoshino, Jayesh Desai, Fortunato Ciardiello, Fotios Loupakis, Yong Sang Hong, Neeltje Steeghs, Tormod Kyrre Guren, Hendrik-Tobias Arkenau, Pilar Garcia-Alfonso, Ashwin Gollerkeri, Kati Maharry, Janna Christy-Bittel, Christopher Hunt Keir, Michael D Pickard, Josep Tabernero

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

Utilisation of systemic therapy options in routine treatment of metastatic colorectal cancer in Australia

Rachel Delahunty, Margaret Lee, Hui-Li Wong, Julie Johns, Joseph Mckendrick, Belinda Lee, Suzanne Kosmider, Prasad Cooray, Sumitra Ananda, Jayesh Desai, Ben Tran, Jeanne Tie, Peter Gibbs, Rachel Wong

Journal article  |  2020  |  Internal Medicine Journal

CART-WHEEL.org: An Ethically Approved Online Database for Patient-Entered Data to Facilitate Rare Cancer Research.

Damien Kee, Clare Parker, Susie Bae, Katherine M Tucker, Michelle Harrison, Ibrahim Tohidi-Esfahani, Marita Black, Rachel Delahunty, Sumitra Ananda, Michael Friedlander, Heather E Cunliffe, Peter Gibbs, Jayesh Desai, Judith Trotman, Clare L Scott

Journal article  |  2020  |  JCO Clinical Cancer Informatics

PURPOSE: Rare cancers are challenging for researchers, as clinicians and scientists have difficulty recruiting sufficient patient ..

A Malignant Neoplasm From the Jejunum With a MALAT1-GLI1 Fusion and 26-Year Survival History

Owen William John Prall, Christopher Robert Edward McEvoy, David John Byrne, Amir Iravani, Judy Browning, David Yew-Huong Choong, Bhargavi Yellapu, Sophie O'Haire, Kortnye Smith, Stephen James Luen, Paul Leslie Ross Mitchell, Jayesh Desai, Stephen Bernard Fox, Andrew Fellowes, Huiling Xu

Journal article  |  2020  |  International Journal of Surgical Pathology

The transcription factor GLI1 is a critical effector of the sonic hedgehog pathway. Gene fusions that activate GLI1 have recently ..

First-in-human phase I clinical trial of a combined immune modulatory approach using TetMYB vaccine and Anti-PD-1 antibody in patients with advanced solid cancer including colorectal or adenoid cystic carcinoma: The MYPHISMO study protocol (NCT03287427)

Toan Pham, Lloyd Pereira, Sara Roth, Laura Galletta, Emma Link, Tim Akhurst, Ben Solomon, Michael Michael, Phillip Darcy, Shienny Sampurno, Alexander Heriot, Robert Ramsay, Jayesh Desai

Journal article  |  2019  |  Contemporary Clinical Trials Communications

Background: MYB is a transcription factor that is overexpressed in colorectal cancer (CRC) and also a driver mutation in adenoid c..

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Jude Canon, Karen Rex, Anne Y Saiki, Christopher Mohr, Keegan Cooke, Dhanashri Bagal, Kevin Gaida, Tyler Holt, Charles G Knutson, Neelima Koppada, Brian A Lanman, Jonathan Werner, Aaron S Rapaport, Tisha San Miguel, Roberto Ortiz, Tao Osgood, Ji-Rong Sun, Xiaochun Zhu, John D McCarter, Laurie P Volak, et al.

Journal article  |  2019  |  Nature

A Phase 1 study of AK104, a tetrameric bispecific antibody that targets PD-1 and CTLA-4 in patients with advanced solid tumors

Ben Markman, Ben Tran, Hui Gan, Amy Prawira, Jermaine Coward, Xiaoping Jin, Baiyong Li, Max Wang, Yu Xia, Jayesh Desai, Michael Millward

Conference Proceedings  |  2019  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

iPREDICT: Incorporating complex profiling of patients to enrol onto molecularly directed cancer therapeutics. Preliminary results of the adult and paediatric

Kortnye Smith, Sophie O'Haire, Khuong-Quang Dong-Anh, Ben Markman, Hui Gan, Paul G Ekert, Ken O'Byrne, Michael Milward, Ben Solomon, Ben Tran, Clare Scott, Grant McArthur, Damien Kee, Andrew Fellowes, Huiling Xu, Melissa Martyn, Elly Lynch, Paula Lorgelly, Clara Gaff, Stephen Fox, et al.

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

BEACON CRC: A randomized, 3-Arm, phase 3 study of Encorafenib (ENCO) and Cetuximab (CETUX) with or without Binimetinib (BINI) versus choice of either Irinotecan or FOLFIRI plus Cetuximab in BRAF V600E-mutant metastatic colorectal cancer

Jayesh Desai, Scott Kopetz, Axel Grothey, Eric Van Cutsem, Rona Yaeger, Harpreet Wasan, Takayuki Yoshino, Fortunato Ciardello, Ashwin Gollerkeri, Kati Maharry, Fotios Loupakis, Yong Sang Hong, Neeltje Steeghs, Tormod Kyrre Guren, Hendrik-Tobias Arkenau, Pilar Garcia Alfonso, Timothy Price, Andrew Strickland, Niall Tebbutt, Christos Karapetis, et al.

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer

S Kopetz, A Grothey, R Yaeger, E Van Cutsem, J Desai, T Yoshino, H Wasan, F Ciardiello, F Loupakis, YS Hong, N Steeghs, TK Guren, H-T Arkenau, P Garcia-Alfonso, P Pfeiffer, S Orlov, S Lonardi, E Elez, T-W Kim, JHM Schellens, et al.

Journal article  |  2019  |  New England Journal of Medicine

BACKGROUND: Patients with metastatic colorectal cancer with the BRAF V600E mutation have a poor prognosis, with a median overall s..

Long-term efficacy of imatinib mesylate in patients with advanced Tenosynovial Giant Cell Tumor

FGM Verspoor, MJL Mastboom, G Hannink, RG Maki, A Wagner, E Bompas, J Desai, A Italiano, BM Seddon, WTA van der Graaf, J-Y Blay, M Brahmi, L Eberst, S Stacchiotti, O Mir, MAJ van de Sande, H Gelderblom, PA Cassier

Journal article  |  2019  |  Scientific Reports

Tenosynovial giant cell tumors (TGCT), are rare colony stimulating factor-1(CSF-1)-driven proliferative disorders affecting joints..

BEACON: A Randomised, Phase 3 Study of Encorafenib and Cetuximab plus /- Binimetinib vs. Choice of Either Irinotecan or FOLFIRI plus Cetuximab in BRAF V600E-Mutant Metastatic Colorectal Cancer Patients

Harpreet Wasan, Tobias Arkenau, Mike Braun, Leslie Samuel, Janet Graham, Scott Kopetz, Axel Grothey, Eric Van Cutsem, Rona Yaeger, Takayuki Yoshino, Jayesh Desai, Fortunato Ciardello, Ashwin Gollerkeri, Kati Maharry, Victor Sandor, Janna Christy-Bittel, Lisa Anderson, Josep Tabernero

Conference Proceedings  |  2019  |  BRITISH JOURNAL OF CANCER

Lack of clinical activity with crizotinib in a patient with FUS rearranged rhabdomyosarcoma with ALK protein overexpression

Jeremy Lewin, Jayesh Desai, Kortnye Smith, Stephen Luen, Daniel Wong

Journal article  |  2019  |  Pathology

Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial

William D Tap, Hans Gelderblom, Emanuela Palmerini, Jayesh Desai, Sebastian Bauer, Jean-Yves Blay, Thierry Alcindor, Kristen Ganjoo, Javier Martin-Broto, Christopher W Ryan, David M Thomas, Charles Peterfy, John H Healey, Michiel van de Sande, Heather L Gelhorn, Dale E Shuster, Qiang Wang, Antoine Yver, Henry H Hsu, Paul S Lin, et al.

Journal article  |  2019  |  The Lancet

Novel vaccine targeting colonic adenoma: A pre-clinical model

Toan D Pham, Sandra Carpinteri, Shienny Sampurno, Lloyd Pereira, Sara Roth, Vignesh Narasimhan, Kasmira Wilson, Phillip Darcy, Jayesh Desai, Alexander G Heriot, Robert G Ramsay

Conference Proceedings  |  2019  |  Clinical Research (Excluding Clinical Trials)

BEACON CRC: a randomized, 3-Arm, phase 3 study of encorafenib and cetuximab with or without binimetinib vs. choice of either irinotecan or FOLFIRI plus cetuximab in BRAF V600E-mutant metastatic colorectal cancer.

S Kopetz, A Grothey, E Van Cutsem, R Yaeger, H Wasan, T Yoshino, J Desai, F Ciardiello, A Gollerkeri, K Maharry, F Loupakis, Y Hong, N Steeghs, T Guren, H Arkenau, P García Alfonso, V Sandor, J Christy-Bittel, L Anderson, J Tabernero

Conference Proceedings  |  2019  |  Annals of Oncology

Phase Ib study of atezolizumab combined with cobimetinib in patients with solid tumors

MD Hellmann, T-W Kim, CB Lee, B-C Goh, WH Miller, D-Y Oh, R Jamal, C-E Chee, LQM Chow, JF Gainor, J Desai, BJ Solomon, M Das Thakur, B Pitcher, P Foster, G Hernandez, MJ Wongchenko, E Cha, Y-J Bang, LL Siu, et al.

Journal article  |  2019  |  Annals of Oncology

BACKGROUND: Preclinical evidence suggests that MEK inhibition promotes accumulation and survival of intratumoral tumor-specific T ..

Long-term exposure (LTE) to Tislelizumab, an investigational anti-PD-1 antibody, in a first-in-human Phase I study

Jayesh Desai, Benjamin Markman, Michael Friedlander, Hui Gan, Lisa Horvath, Amanda Townsend, Michael Millward, Michael Jameson, Chia-Jui Yen, Ming-Mo Hou, Jeannie Hou, John Wu, Liang Liang, Sanjeev Deva

Conference Proceedings  |  2019  |  Clinical Trials

Binimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With BRAF V600E-Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study

Eric Van Cutsem, Sanne Huijberts, Axel Grothey, Rona Yaeger, Pieter-Jan Cuyle, Elena Elez, Marwan Fakih, Clara Montagut, Marc Peeters, Takayuki Yoshino, Harpreet Wasan, C Jayesh Desai, Fortunato Ciardiello, Ashwin Gollerkeri, Janna Christy-Bittel, Kati Maharry, Victor Sandor, Jan Hm Schellens, Scott Kopetz, Josep Tabernero

Journal article  |  2019  |  Journal of Clinical Oncology

PURPOSE: To determine the safety and preliminary efficacy of selective combination targeted therapy for BRAF V600E-mutant metastat..

The value of networks in driving phase I trials: the Peter MacCallum Cancer Centre experience

Jayesh Desai, Christina Guo, Ben Tran

Journal article  |  2019  |  Chinese Clinical Oncology

Phase 1 study evaluating the safety, tolerability, pharmacokinetics (PK), and efficacy of AMG 510, a novel small molecule KRAS(G12c) inhibitor, in advanced solid tumors.

Marwan Fakih, Bert O'Neil, Timothy Jay Price, Gerald Steven Falchook, Jayesh Desai, James Kuo, Ramaswamy Govindan, Erik Rasmussen, Phuong Khanh H Morrow, Jude Ngang, Haby A Henary, David S Hong

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Responder analysis of patient-reported outcomes measurement information system (PROM'S) physical function (PF) and worst stiffness among patients with tenosynovial giant cell tumors (TGCT) in the ENLIVEN study.

William D Tap, Rebecca M Speck, Xin Ye, Emanuela Palmerini, Silvia Stacchiotti, Jayesh Desai, Andrew J Wagner, Thierry Alcindor, Kristen N Ganjoo, Javier Martin Broto, Qiang Wang, Dale Edward Shuster, Heather Gelhorn, Hans Gelderblom

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Pexidartinib for advanced tenosynovial giant cell tumor (TGCT): Long-term efficacy and safety from the phase 3 ENLIVEN and phase 1 PLX108-01 (TGCT cohort) studies.

Hans Gelderblom, William D Tap, Emanuela Palmerini, Silvia Stacchiotti, Zev A Wainberg, Jayesh Desai, John H Healey, Michiel van de Sande, Nicholas M Bernthal, Charles Peterfy, Dale Edward Shuster, Qiang Wang, Henry Hsu, Andrew J Wagner

Conference Proceedings  |  2019  |  JOURNAL OF CLINICAL ONCOLOGY

Profound MEK inhibitor response in a cutaneous melanoma harboring a GOLGA4-RAF1 fusion

Christopher R McEvoy, Huiling Xu, Kortnye Smith, Dariush Etemadmoghadam, Huei San Leong, David Y Choong, David J Byrne, Amir Iravani, Sophie Beck, Linda Mileshkin, Richard W Tothill, David D Bowtell, Bindi M Bates, Violeta Nastevski, Judy Browning, Anthony H Bell, Chloe Khoo, Jayesh Desai, Andrew P Fellowes, Stephen B Fox, et al.

Journal article  |  2019  |  Journal of Clinical Investigation

Novel Vaccine Targeting Colonic Adenoma: a Pre-clinical Model

Toan Pham, Sandra Carpinteri, Shienny Sampurno, Lloyd Pereira, Sara Roth, Vignesh Narasimhan, Phillip Darcy, Jayesh Desai, Alexander G Heriot, Robert G Ramsay

Journal article  |  2019  |  Journal of Gastrointestinal Surgery

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer

Sheau W Lok, James R Whittle, Francois Vaillant, Charis E Teh, Louisa L Lo, Antonia N Policheni, Alice RT Bergin, Jayesh Desai, Sarah Ftouni, Luke C Gandolfo, Danny Liew, He K Liu, G Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W Roberts, Mark A Rosenthal, Kylie Shackleton, Maria Joao Silva, et al.

Journal article  |  2019  |  Cancer Discovery

BMS-986205, an indoleamine 2, 3-dioxygenase 1 inhibitor (IDO1i), in combination with nivolumab (nivo): Updated safety across all tumor cohorts and efficacy in advanced bladder cancer (advBC).

Jason J Luke, Josep Tabernero, Anthony Joshua, Jayesh Desai, Andrea I Varga, Victor Moreno, Carlos A Gomez-Roca, Ben Markman, Filippo G De Braud, Sandip Pravin Patel, Matteo S Carlino, Lillian L Siu, Giuseppe Curigliano, Zhaohui Liu, Yuko Ishii, Megan Wind-Rotolo, Paul Andrew Basciano, Alex Azrilevich, Karen A Gelmon

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

MORPHEUS: A phase Ib/II study platform evaluating the safety and clinical efficacy of cancer immunotherapy (CIT)-based combinations in gastrointestinal (GI) cancers.

Jayesh Desai, Jeremy S Kortmansky, Neil Howard Segal, Marwan Fakih, Do-Youn Oh, Kyu-Pyo Kim, Osama E Rahma, Andrew H Ko, Hyun Cheol Chung, Maria Alsina, Kun-Huei Yeh, Shi Li, Nedal Jaffer Abdulla Al-Sakaff, Jilpa Patel, Hila Barak, Jun Wang, Xiaosong Zhang, Conrad Bleul, Edward Cha, Jeeyun Lee

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Updated results of the BEACON CRC safety lead-in: Encorafenib (ENCO) plus binimetinib (BIM) plus cetuximab (CETUX) for BRAFV600E-mutant metastatic colorectal cancer (mCRC).

Scott Kopetz, Axel Grothey, Rona Yaeger, Pieter-Jan AR Cuyle, Sanne Huijberts, Jan HM Schellens, Elena Elez, Marwan Fakih, Clara Montagut Viladot, Marc Peeters, Jayesh Desai, Takayuki Yoshino, Fortunato Ciardiello, Harpreet Singh Wasan, Kati Maharry, Janna Christy-Bittel, Ashwin Gollerkeri, Eric Van Cutsem, Josep Tabernero

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Wither surgical oncology?

Toan D Pham, Vignesh Narasimhan, Glen Guerra, Joseph Kong, Jayesh Desai, Robert Ramsay, Alexander Heriot

Journal article  |  2019  |  ANZ Journal of Surgery

A multi-arm phase I dose escalating study of an oral NOTCH inhibitor BMS-986115 in patients with advanced solid tumours

Kyaw L Aung, Anthony B El-Khoueiry, Karen Gelmon, Ben Tran, Gaurav Bajaj, Bing He, Tian Chen, Lili Zhu, Sharath Poojary, Shashwati Basak, Zhenhao Qi, Anna Spreafico, Bruce S Fischer, Jayesh Desai

Journal article  |  2018  |  Investigational New Drugs

ASO Author Reflections: Immunotherapy for Solid Tumors: A Review

Pham Toan, Sara Roth, Jayesh Desai, Robert Ramsay, Alexander Heriot

Journal article  |  2018  |  Annals of Surgical Oncology

A phase 1, first-in-human study of AMG 900, an orally administered pan-Aurora kinase inhibitor, in adult patients with advanced solid tumors

Michael Carducci, Montaser Shaheen, Ben Markman, Sara Hurvitz, Daruka Mahadevan, Dusan Kotasek, Oscar B Goodman, Erik Rasmussen, Vincent Chow, Gloria Juan, Gregory R Friberg, Erick Gamelin, Florian D Vogl, Jayesh Desai

Journal article  |  2018  |  Investigational New Drugs

Cetuximab Alone or With Irinotecan for Resistant KRAS-, NRAS-, BRAF- and PIK3CA-wild-type Metastatic Colorectal Cancer: The AGITG Randomized Phase II ICECREAM Study

Jeremy D Shapiro, Subotheni Thavaneswaran, Craig R Underhill, Kristy P Robledo, Christos S Karapetis, Fiona L Day, Louise M Nott, Michael Jefford, Lorraine A Chantrill, Nick Pavlakis, Niall C Tebbutt, Timothy J Price, Mustafa Khasraw, Guy A Van Hazel, Paul M Waring, Sabine Tejpar, John Simes, Val J Gebski, Jayesh Desai, Eva Segelov

Journal article  |  2018  |  Clinical Colorectal Cancer

Tumor-Infiltrating Lymphocyte Function Predicts Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer

Joseph Cherng Huei Kong, Glen Robert Guerra, Rosemary Magdalena Millen, Sara Roth, Huiling Xu, Paul Joseph Neeson, Phillip Kevin Darcy, Michael Henry Kershaw, Shienny Sampurno, Jordane Malaterre, David Shi Hao Liu, Duc Pham Toan, Vignesh Narasimhan, Minyu Wang, Yu-Kuan Huang, Kumar Visvanathan, Jacob McCormick, Andrew Craig Lynch, Satish Warrier, Michael Michael, et al.

Journal article  |  2018  |  JCO Precision Oncology

Gender differences in doxorubicin pharmacology for subjects with chemosensitive cancers of young adulthood

Z Liu, J Martin, L Orme, B Seddon, J Desai, W Nicholls, D Thomson, D Porter, G McCowage, C Underhill, N Cranswick, M Michael, M Zacharin, A Herschtal, J Sivasuthan, DM Thomas

Journal article  |  2018  |  Cancer Chemotherapy and Pharmacology

Phase I investigator's perceptions to 'supersized seamless trials in oncology'

BBY Ma, N van der Velden, F Mo, HH Loong, L Siu, BC Goh, YJ Bang, CC Lin, J Desai, MP Lolkema

Conference Proceedings  |  2018  |  Annals of Oncology

Treatment of patients with primary retroperitoneal sarcoma: predictors of outcome from an Australian specialist sarcoma centre

Hayden A Snow, Tatiana X Hitchen, Jessica Head, Alan Herschtal, Susie Bae, Sarat Chander, Julie Chu, Shona Hendry, Samuel Y Ngan, Jayesh Desai, Peter FM Choong, Michael Henderson, David E Gyorki

Journal article  |  2018  |  ANZ Journal of Surgery

A phase I trial to determine safety and pharmacokinetics of ASLAN002, an oral MET superfamily kinase inhibitor, in patients with advanced or metastatic solid cancers

Aflah Roohullah, Adam Cooper, Anna J Lomax, Jennifer Aung, Alan Barge, Lilian Chow, Mark McHale, Jayesh Desai, James R Whittle, Ben Tran, Paul de Souza, Lisa G Horvath

Journal article  |  2018  |  Investigational New Drugs

Phase I/II study investigating safety, tolerability, pharmacokinetics, and preliminary antitumor activity of anti-PD-L1 monoclonal antibody BGB-A333 alone and in combination with anti-PD-1 monoclonal antibody tislelizumab in patients with advanced solid tumors

J Desai, M Voskoboynik, B Markman, J Hou, D Zeng, T Meniawy

Conference Proceedings  |  2018  |  Annals of Oncology

An Update on Immunotherapy for Solid Tumors: A Review

Toan Pham, Sara Roth, Joseph Kong, Glen Guerra, Vignesh Narasimhan, Lloyd Pereira, Jayesh Desai, Alexander Heriot, Robert Ramsay

Journal article  |  2018  |  Annals of Surgical Oncology

MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

Anuratha Sakthianandeswaren, Marie J Parsons, Dmitri Mouradov, Ruth N MacKinnon, Bruno Catimel, Sheng Liu, Michelle Palmieri, Christopher Love, Robert N Jorissen, Shan Li, Lachlan Whitehead, Tracy L Putoczki, Adele Preaudet, Cary Tsui, Cameron J Nowell, Robyn L Ward, Nicholas J Hawkins, Jayesh Desai, Peter Gibbs, Matthias Ernst, et al.

Journal article  |  2018  |  Cancer Discovery

Mechanistic Insights of an Immunological Adverse Event Induced by an Anti-KIT Antibody Drug Conjugate and Mitigation Strategies

Lawrence L'Italien, Olivia Orozco, Tinya Abrams, Lisa Cantagallo, Anu Connor, Jayesh Desai, Hilmar Ebersbach, Hans Gelderblom, Keith Hoffmaster, Emma Lees, Heiko Maacke, Siew Schleyer, Darko Skegro, Si Tuen Lee-Hoeflich

Journal article  |  2018  |  Clinical Cancer Research

Systematic Review of Clinical Outcomes Following Various Treatment Options for Patients with Extraabdominal Desmoid Tumors

Kortnye Smith, Jayesh Desai, Smaro Lazarakis, David Gyorki

Journal article  |  2018  |  Annals of Surgical Oncology

BEACON CRC study safety lead-in: Assessment of the BRAF inhibitor encorafenib MEK inhibitor binimetinib anti-epidermal growth factor receptor antibody cetuximab for BRAFV600E metastatic colorectal cancer.

E Van Cutsem, P Cuyle, S Huijberts, J Schellens, E Elez, R Yaeger, M Fakih, C Montagut, M Peeters, J Desai, T Yoshino, F Ciardiello, H Wasan, K Maharry, J Christy-Bittel, A Gollerkeri, S Kopetz, A Grothey, J Tabernero

Conference Proceedings  |  2018  |  Annals of Oncology

Safety, efficacy and pharmacodynamics (PD) of MEDI9447 (oleclumab) alone or in combination with durvalumab in advanced colorectal cancer (CRC) or pancreatic cancer (panc).

Michael J Overman, Patricia LoRusso, John H Strickler, Sandip Pravin Patel, Stephen John Clarke, Anne M Noonan, Thiru Prasanna, Manik A Amin, John J Nemunaitis, Jayesh Desai, Kenneth John O'Byrne, Thomas J George, Judson Englert, Dewei She, Zachary A Cooper, Yuling Wu, Anis Khan, Rakesh Kumar, Johanna C Bendell

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

Final results of ENLIVEN: A global, double-blind, randomized, placebo-controlled, phase 3 study of pexidartinib in advanced tenosynovial giant cell tumor (TGCT).

William D Tap, Hans Gelderblom, Silvia Stacchiotti, Emanuela Palmerini, Stefano Ferrari, Jayesh Desai, Sebastian Bauer, Jean-Yves Blay, Thierry Alcindor, Kristen N Ganjoo, Javier Martin Broto, Christopher W Ryan, Dale Edward Shuster, Ling Zhang, Qiang Wang, Henry Hsu, Paul S Lin, Sandra Tong, Andrew J Wagner

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

BMS-986205, an indoleamine 2,3-dioxygenase 1 inhibitor (IDO1i), in combination with nivolumab (NIVO): Updated safety across all tumor cohorts and efficacy in pts with advanced bladder cancer (advBC).

Josep Tabernero, Jason J Luke, Anthony M Joshua, Andrea I Varga, Victor Moreno, Jayesh Desai, Ben Markman, Carlos Alberto Gomez-Roca, Filippo G De Braud, Sandip Pravin Patel, Matteo S Carlino, Lillian L Siu, Giuseppe Curigliano, Zhaohui Liu, Yuko Ishii, Penny Phillips, Megan Wind-Rotolo, Paul Andrew Basciano, Alex Azrilevich, Karen A Gelmon

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

Preliminary results from patients with urothelial carcinoma (UC) in a phase 1A/1B study of bgb-A317, an anti-PD-1 monoclonal antibody.

Shahneen Kaur Sandhu, Andrew Graham Hill, Hui Kong Gan, Michael Friedlander, Mark Voskoboynik, Paula Barlow, Amanda Rose Townsend, James Song, Yun Zhang, Zhirong Shen, Qinzhou Qi, Jayesh Desai

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

A phase Ib study of safety and clinical activity of atezolizumab (A) and cobimetinib (C) in patients (pts) with metastatic colorectal cancer (mCRC).

Johanna C Bendell, Yung-Jue Bang, Cheng Ean Chee, David P Ryan, Autumn Jackson McRee, Laura Q Chow, Jayesh Desai, Matthew Wongchenko, Yibing Yan, Bethany Pitcher, Paul Foster, Edward Cha, William Grossman, Tae Won Kim

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

Precision oncology using a clinician-directed, tailored approach to molecular profiling

Michael Lam, Ben Tran, Sophie Beck, Jeanne Tie, Dishan Herath, James Whittle, Edmond M Kwan, Stephen B Fox, Andrew Fellowes, Sumitra Ananda, Lara Lipton, Peter Gibbs, Mark A Rosenthal, Jayesh Desai

Journal article  |  2018  |  Asia-Pacific Journal of Clinical Oncology

BEACON CRC study safety lead-in (SLI) in patients with BRAF(V600E) metastatic colorectal cancer (mCRC): Efficacy and tumor markers.

Eric Van Cutsem, Pieter-Jan Cuyle, Sanne Huijberts, Rona Yaeger, Jan HM Schellens, Elena Elez, Josep Tabernero, Marwan Fakih, Clara Montagut, Marc Peeters, Jayesh Desai, Takayuki Yoshino, Fortunato Ciardiello, Harpreet Singh Wasan, Scott Kopetz, Kati Maharry, Janna Christy-Bittel, Ashwin Gollerkeri, Axel Grothey

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

Nivolumab for the treatment of colorectal cancer

Kortnye Maureen Smith, Jayesh Desai

Journal article  |  2018  |  Expert Review of Anticancer Therapy

Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study

Michael J Overman, Ray McDermott, Joseph L Leach, Sara Lonardi, Heinz-Josef Lenz, Michael A Morse, Jayesh Desai, Andrew Hill, Michael Axelson, Rebecca A Moss, Monica V Goldberg, Z Alexander Cao, Jean-Marie Ledeine, Gregory A Maglinte, Scott Kopetz, Thierry Andre

Journal article  |  2017  |  The Lancet Oncology

Survival Impact of Adjuvant Chemotherapy for Resected Locally Advanced Rectal Adenocarcinoma

Rebecca Y Tay, Murtaza Jamnagerwalla, Malcolm Steel, Hui-Li Wong, Joseph J McKendrick, Ian Faragher, Suzanne Kosmider, Ian Hastie, Jayesh Desai, Mark Tacey, Peter Gibbs, Rachel Wong

Journal article  |  2017  |  CLINICAL COLORECTAL CANCER

Safety and efficacy of the BCL2 inhibitor venetoclax in estrogen receptor (ER) and BCL2-positive metastatic breast cancer: The mBEP study.

Geoffrey John Lindeman, Sheau Wen Lok, Alice Ruth Bergin, James Richard Whittle, Kylie Shackleton, Peter Sherman, Sarah-Jane Dawson, Jayesh Desai, Danny Liew, Bruce Mann, Anand Murugasu, Andrew Warwick Roberts, Mark Rosenthal, Jane Visvader

Conference Proceedings  |  2017  |  Journal of Clinical Oncology

BEACON CRC (binimetinib [BIM], encorafenib [ENCO], and cetuximab [CTX] combined to treat BRAF-mutant metastatic colorectal cancer [mCRC]): A multicenter, randomized, open-label, three-arm phase III study of ENCO plus CTX plus or minus BINI vs irinotecan (IRI)/CTX or infusional 5-fluorouracil/folinic acid/IRI (FOLFIRI)ICTX with

Sanne Huijberts, Jan HM Schellens, Marwan Fakih, Marc Peeters, Scott Kopetz, Axel Grothey, Eric Van Cutsem, Harpreet Singh Wasan, Jayesh Desai, Fortunato Ciardiello, Takayuki Yoshino, Kati Maharry, Ashwin Gollerkeri, Josep Tabernero

Conference Proceedings  |  2017  |  Journal of Clinical Oncology

Nivolumab in patients with DNA mismatch repair deficient/microsatellite instability high metastatic colorectal cancer: Update from CheckMate 142.

Michael J Overman, Sara Lonardi, Francesco Leone, Raymond S McDermott, Michael A Morse, Ka Yeung Mark Wong, Bart Neyns, Joseph L Leach, Pilar Garcia Alfonso, James J Lee, Andrew Hill, Heinz-Josef Lenz, Jayesh Desai, Rebecca A Moss, Z Alexander Cao, Jean-Marie Ledeine, Hao Tang, Scott Kopetz, Thierry Andre

Conference Proceedings  |  2017  |  Journal of Clinical Oncology

Examining the impact of regular aspirin use and PIK3CA mutations on survival in stage 2 colon cancer

Caitlin Murphy, Natalie Turner, Hui-Li Wong, Mathu Sinnathamby, Jeanne Tie, Belinda Lee, Jayesh Desai, Iain Skinner, Michael Christie, Ryan Hutchinson, Sebastian Lunke, Paul Waring, Peter Gibbs, Tran Ben

Journal article  |  2017  |  Internal Medicine Journal

Variations of Surveillance Practice for Patients with Bone Sarcoma: A Survey of Australian Sarcoma Clinicians.

Jeremy Lewin, Kate Thompson, Susie Bae, Jayesh Desai, Robyn Strong, Denise Caruso, Deborah Howell, Alan Herschtal, Michael Sullivan, Lisa Orme

Journal article  |  2017  |  Sarcoma

Introduction. After treatment, bone sarcoma patients carry a high chance of relapse and late effects from multimodal therapy. We h..

Girdin (GIV) Expression as a Prognostic Marker of Recurrence in Mismatch Repair-Proficient Stage II Colon Cancer

Pradipta Ghosh, Jeanne Tie, Andrea Muranyi, Shalini Singh, Patrick Brunhoeber, Katherine Leith, Rebecca Bowermaster, Zhiming Liao, Yifei Zhu, Bonnie LaFleur, Ben Tran, Jayesh Desai, Ian Jones, Matthew Croxford, Rodrigo Jover, Ajay Goel, Paul Waring, Song Hu, Volker Teichgraber, Ulrich-Peter Rohr, et al.

Journal article  |  2016  |  Clinical Cancer Research

Patterns of care for patients with advanced soft tissue sarcoma: experience from Australian sarcoma services

Susie Bae, Philip Crowe, Raghu Gowda, Warren Joubert, Richard Carey-Smith, Paul Stalley, Jayesh Desai

Journal article  |  2016  |  Clinical Sarcoma Research

Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

Jeanne Tie, Yuxuan Wang, Cristian Tomasetti, Lu Li, Simeon Springer, Isaac Kinde, Natalie Silliman, Mark Tacey, Hui-Li Wong, Michael Christie, Suzanne Kosmider, Iain Skinner, Rachel Wong, Malcolm Steel, Ben Tran, Jayesh Desai, Ian Jones, Andrew Haydon, Theresa Hayes, Tim J Price, et al.

Journal article  |  2016  |  Science Translational Medicine

Response to Cetuximab With or Without Irinotecan in Patients With Refractory Metastatic Colorectal Cancer Harboring the KRAS G13D Mutation: Australasian Gastro-Intestinal Trials Group ICECREAM Study

Eva Segelov, Subotheni Thavaneswaran, Paul M Waring, Jayesh Desai, Kristy P Robledo, Val J Gebski, Elena Elez, Louise M Nott, Christos S Karapetis, Sebastian Lunke, Lorraine A Chantrill, Nick Pavlakis, Mustafa Khasraw, Craig Underhill, Fortunato Ciardiello, Michael Jefford, Harpreet Wasan, Andrew Haydon, Timothy J Price, Guy van Hazel, et al.

Journal article  |  2016  |  Journal of Clinical Oncology

Impact of Primary Tumor Site on Bevacizumab Efficacy in Metastatic Colorectal Cancer

Hui-li Wong, Belinda Lee, Kathryn Field, Anna Lomax, Mark Tacey, Jeremy Shapiro, Joe McKendrick, Allan Zimet, Desmond Yip, Louise Nott, Ross Jennens, Gary Richardson, Jeanne Tie, Suzanne Kosmider, Phillip Parente, Lionel Lim, Prasad Cooray, Tran Ben, Jayesh Desai, Rachel Wong, et al.

Journal article  |  2016  |  CLINICAL COLORECTAL CANCER

ICECREAM: randomised phase II study of cetuximab alone or in combination with irinotecan in patients with metastatic colorectal cancer with either KRAS, NRAS, BRAF and PI3KCA wild type, or G13D mutated tumours

Eva Segelov, Paul Waring, Jayesh Desai, Kate Wilson, Val Gebski, Subotheni Thavaneswaran, Elena Elez, Craig Underhill, Nick Pavlakis, Lorraine Chantrill, Louise Nott, Michael Jefford, Mustafa Khasraw, Fiona Day, Harpreet Wasan, Fortunato Ciardiello, Chris Karapetis, Warren Joubert, Guy van Hazel, Andrew Haydon, et al.

Journal article  |  2016  |  BMC Cancer

First-in-Man Dose-Escalation Study of the Selective BRAF Inhibitor RG7256 in Patients with BRAF V600-Mutated Advanced Solid Tumors

Rodrigo Dienstmann, Ulrik Lassen, Jonathan Cebon, Jayesh Desai, Michael P Brown, Stefan Evers, Fei Su, Weijiang Zhang, Frederic Boisserie, Brian Lestini, Kathleen Schostack, Valerie Meresse, Josep Tabernero

Journal article  |  2016  |  Targeted Oncology

Survival impact of the Australian National Bowel Cancer Screening Programme

S Ananda, H Wong, I Faragher, IT Jones, M Steele, S Kosmider, J Desai, J Tie, K Field, R Wong, B Tran, S Bae, P Gibbs

Journal article  |  2016  |  Internal Medicine Journal

Analysis of local chronic inflammatory cell infiltrate combined with systemic inflammation improves prognostication in stage II colon cancer independent of standard clinicopathologic criteria

Natalie Turner, Hui-Li Wong, Arnoud Templeton, Sagarika Tripathy, Te Whiti Rogers, Matthew Croxford, Ian Jones, Mathuranthakan Sinnathamby, Jayesh Desai, Jeanne Tie, Susie Bae, Michael Christie, Peter Gibbs, Ben Tran

Journal article  |  2016  |  International Journal of Cancer

Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer

Rosemary Millen, Jordane Malaterre, Ryan S Cross, Sandra Carpinteri, Jayesh Desai, Ben Tran, Phillip Darcy, Peter Gibbs, Oliver Sieber, Nikolajs Zeps, Paul Waring, Stephen Fox, Lloyd Pereira, Robert G Ramsay

Journal article  |  2016  |  OncoImmunology

A First-Time-In-Human Phase I Clinical Trial of Bispecific Antibody-Targeted, Paclitaxel-Packaged Bacterial Minicells

Benjamin J Solomon, Jayesh Desai, Mark Rosenthal, Grant A McArthur, Scott T Pattison, Stacey L Pattison, Jennifer MacDiarmid, Himanshu Brahmbhatt, Andrew M Scott

Journal article  |  2015  |  PLOS ONE

Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer

Scott Kopetz, Jayesh Desai, Emily Chan, Joel Randolph Hecht, Peter J O'Dwyer, Dipen Maru, Morris Van, Filip Janku, Arvind Dasari, Woonbook Chung, Jean-Pierre J Issa, Peter Gibbs, Brian James, Garth Powis, Keith B Nolop, Suman Bhattacharya, Leonard Saltz

Journal article  |  2015  |  Journal of Clinical Oncology

Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer

Robert N Jorissen, Michael Christie, Dmitri Mouradov, Anuratha Sakthianandeswaren, Shan Li, Christopher Love, Zheng-Zhou Xu, Peter L Molloy, Ian T Jones, Stephen McLaughlin, Robyn L Ward, Nicholas J Hawkins, Andrew R Ruszkiewicz, James Moore, Antony W Burgess, Dana Busam, Qi Zhao, Robert L Strausberg, Lara Lipton, Jayesh Desai, et al.

Journal article  |  2015  |  British Journal of Cancer

Novel quality indicators for metastatic colorectal cancer management identify significant variations in these measures across treatment centers in Australia

Natalie Heather Turner, Hui-li Wong, Kathryn Field, Rachel Wong, Jeremy Shapiro, Desmond Yip, Louise Nott, Jeanne Tie, Suzanne Kosmider, Ben Tran, Jayesh Desai, Joseph McKendrick, Allan Zimet, Gary Richardson, Mahesh Iddawela, Peter Gibbs

Journal article  |  2015  |  Asia-Pacific Journal of Clinical Oncology

Primary Tumor Resection in Patients With Metastatic Colorectal Cancer Is Associated With Reversal of Systemic Inflammation and Improved Survival

Natalie Turner, Ben Tran, Phillip V Tran, Mathuranthakan Sinnathamby, Hui-Li Wong, Ian Jones, Matthew Croxford, Jayesh Desai, Jeanne Tie, Kathryn Maree Field, Suzanne Kosmider, Susie Bae, Peter Gibbs

Journal article  |  2015  |  Clinical Colorectal Cancer

Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer

J Tie, I Kinde, Y Wang, HL Wong, J Roebert, M Christie, M Tacey, R Wong, M Singh, CS Karapetis, J Desai, B Tran, RL Strausberg, LA Diaz, N Papadopoulos, KW Kinzler, B Vogelstein, P Gibbs

Journal article  |  2015  |  Annals of Oncology

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma

Ankita Gupte, Emma K Baker, Soo-San Wan, Elizabeth Stewart, Amos Loh, Anang A Shelat, Cathryn M Gould, Alistair M Chalk, Scott Taylor, Kurt Lackovic, Asa Karlstroem, Anthony J Mutsaers, Jayesh Desai, Piyush B Madhamshettiwar, Andrew CW Zannettino, Chris Burns, David CS Huang, Michael A Dyer, Kaylene J Simpson, Carl R Walkley

Journal article  |  2015  |  Clinical Cancer Research

Targeting BRAF mutant metastatic colorectal cancer: clinical implications and emerging therapeutic strategies

Jeanne Tie, Jayesh Desai

Journal article  |  2015  |  Targeted Oncology

Histone Deacetylase Inhibitors in Cancer: What Have We Learned?

James R Whittle, Jayesh Desai

Journal article  |  2015  |  Cancer

Impact of regular aspirin use on overall and cancer-specific survival in patients with colorectal cancer harboring a PIK3CA mutation

Nishi Kothari, Richard Kim, Robert N Jorissen, Jayesh Desai, Jeanne Tie, Hui-Li Wong, Ian Farragher, Ian Jones, Fiona L Day, Shan Li, Anuratha Sakthinandeswaren, Michelle Palmieri, Lara Lipton, Michael Schell, Jamie K Teer, David Shibata, Timothy Yeatman, Oliver M Sieber, Peter Gibbs, Ben Tran

Journal article  |  2015  |  Acta Oncologica

A mutant BRAF V600E-specific immunohistochemical assay: correlation with molecular mutation status and clinical outcome in colorectal cancer

Fiona Day, Andrea Muranyi, Shalini Singh, Kandavel Shanmugam, David Williams, David Byrne, Kym Pham, Michelle Palmieri, Jeanne Tie, Thomas Grogan, Peter Gibbs, Oliver Sieber, Paul Waring, Jayesh Desai

Journal article  |  2015  |  Targeted Oncology

ADVANCES IN OUR UNDERSTANDING AND MANAGEMENT OF SARCOMAS - RARE BONE AND SOFT TISSUE CANCERS

Susie Bae, Jayesh Desai

Journal article  |  2015  |  Cancer Forum

Survival impact of adjuvant chemotherapy for resected early-stage rectal adenocarcinoma.

Rebecca Yin Tay, Murtaza Jamnagerwalla, Malcolm Steel, Hui-Li Wong, Joseph James McKendrick, Ian Faragher, Suzanne Kosmider, Ian Hastie, Jayesh Desai, Peter Gibbs, Rachel Wong

Conference Proceedings  |  2015  |  Journal of Clinical Oncology

Impact of Diabetes Status and Medication on Presentation, Treatment, and Outcome of Stage II Colon Cancer Patients

Susie Bae, Hui-Li Wong, Jeanne Tie, Jayesh Desai, Kathryn Field, Suzanne Kosmider, Spiros Fourlanos, Ian Jones, Iain Skinner, Peter Gibbs

Journal article  |  2015  |  Journal of Cancer Epidemiology

Wiki-based clinical practice guidelines for the management of adult onset sarcoma: a new paradigm in sarcoma evidence.

SJ Neuhaus, D Thomas, J Desai, C Vuletich, J von Dincklage, I Olver

Journal article  |  2015  |  Sarcoma

In 2013 Australia introduced Wiki-based Clinical Practice Guidelines for the Management of Adult Onset Sarcoma. These guidelines u..

A phase Ib/II translational study of sunitinib with neoadjuvant radiotherapy in soft-tissue sarcoma

J Lewin, KK Khamly, RJ Young, C Mitchell, RJ Hicks, GC Toner, SYK Ngan, S Chander, GJ Powell, A Herschtal, L Te Marvelde, J Desai, PFM Choong, SA Stacker, MG Achen, N Ferris, S Fox, J Slavin, DM Thomas

Journal article  |  2014  |  British Journal of Cancer

Translation of clinical trial outcomes to metastatic colorectal cancer patients in community practice

Sheau Wen Lok, Hui-li Wong, Suzanne Kosmider, Kathryn Field, Jeanne Tie, Jayesh Desai, Susie Bae, Mark Tacey, Iain Skinner, Ian Jones, Peter Gibbs

Journal article  |  2014  |  Asia Pacific Journal of Clinical Oncology

Chondroblastic Osteosarcoma Arising in a Bone Infarct in a Patient with a Prior History of Hodgkin Lymphoma

Jeremy Lewin, Peter Choong, Kate Moodie, John Slavin, Jayesh Desai, Lisa M Orme

Journal article  |  2014  |  Journal of Adolescent and Young Adult Oncology

KRAS mutation testing of metastatic colorectal cancer in Australia: Where are we at?

Rodney J Scott, Stephen B Fox, Jayesh Desai, Fabienne Grieu, Benhur Amanuel, Kerryn Garrett, James Harraway, Glenice Cheetham, Neville Pattle, Afaf Haddad, Keith Byron, Barney Rudzki, Paul Waring, Barry Iacopetta

Journal article  |  2014  |  Asia Pacific Journal of Clinical Oncology

Controversies in the management of gastrointestinal stromal tumors

Desmond Yip, John Zalcberg, Stephen Ackland, Andrew P Barbour, Jayesh Desai, Stephen Fox, Dusan Kotasek, Grant McArthur, B Mark Smithers

Journal article  |  2014  |  Asia-Pacific Journal of Clinical Oncology

Multicenter retrospective analysis of metastatic colorectal cancer (CRC) with high-level microsatellite instability (MSI-H)

J Goldstein, B Tran, J Ensor, P Gibbs, HL Wong, SF Wong, E Vilar, J Tie, R Broaddus, S Kopetz, J Desai, MJ Overman

Journal article  |  2014  |  Annals of Oncology

An Australasian perspective on sarcoma research, translational biology and clinical trials: the Australasian Sarcoma Study Group (ASSG)

Susie Bae, Denise Caruso, Jayesh Desai

Journal article  |  2014  |  Pathology

Nutlin-3a Efficacy in Sarcoma Predicted by Transcriptomic and Epigenetic Profiling

Kathleen I Pishas, Susan J Neuhaus, Mark T Clayer, Andreas W Schreiber, David M Lawrence, Michelle Perugini, Robert J Whitfield, Gelareh Farshid, Jim Manavis, Steve Chryssidis, Bronwen J Mayo, Rebecca C Haycox, Kristen Ho, Michael P Brown, Richard J D'Andrea, Andreas Evdokiou, David M Thomas, Jayesh Desai, David F Callen, Paul M Neilsen

Journal article  |  2014  |  Cancer Research

Personalized Management: Inoperable Gastrointestinal Stromal Tumors

Susie Bae, Jayesh Desai

Journal article  |  2014  |  Clinical Gastroenterology and Hepatology

Intra-patient dose escalation in Ewing's sarcoma treated with vincristine, doxorubicin, cyclophosphamide alternating with ifosfamide and etoposide: a retrospective review.

Jeremy Lewin, Samantha Wieringa, Marnie Collins, Jayesh Desai, Lisa Orme, Senthil Lingaratnam, David M Thomas

Journal article  |  2013  |  Clinical Sarcoma Research

BACKGROUND: Data suggests that males experience less toxicity and poorer survival than females treated for Ewing's sarcoma. We ins..

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations

Dmitri Mouradov, Enric Domingo, Peter Gibbs, Robert N Jorissen, Shan Li, Pik Ying Soo, Lara Lipton, Jayesh Desai, Havard E Danielsen, Dahmane Oukrif, Marco Novelli, Christopher Yau, Christopher C Holmes, Ian T Jones, Stephen McLaughlin, Peter Molloy, Nicholas J Hawkins, Robyn Ward, Rachel Midgely, David Kerr, et al.

Journal article  |  2013  |  American Journal of Gastroenterology

Developing a national database for metastatic colorectal cancer management: perspectives and challenges

K Field, H-L Wong, J Shapiro, S Kosmider, J Tie, S Bae, D Yip, J McKendrick, L Nott, J Desai, M Harold, L Lipton, G Stefanou, L Lim, P Parente, P Gibbs

Journal article  |  2013  |  Internal Medicine Journal

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/beta-catenin signalling thresholds for tumourigenesis

M Christie, RN Jorissen, D Mouradov, A Sakthianandeswaren, S Li, F Day, C Tsui, L Lipton, J Desai, IT Jones, S McLaughlin, RL Ward, NJ Hawkins, AR Ruszkiewicz, J Moore, AW Burgess, D Busam, Q Zhao, RL Strausberg, AJ Simpson, et al.

Journal article  |  2013  |  Oncogene

PIK3CA and PTEN Gene and Exon Mutation-Specific Clinicopathologic and Molecular Associations in Colorectal Cancer

Fiona L Day, Robert N Jorissen, Lara Lipton, Dmitri Mouradov, Anuratha Sakthianandeswaren, Michael Christie, Shan Li, Cary Tsui, Jeannie Tie, Jayesh Desai, Zheng-Zhou Xu, Peter Molloy, Vicki Whitehall, Barbara A Leggett, Ian T Jones, Stephen McLaughlin, Robyn L Ward, Nicholas J Hawkins, Andrew R Ruszkiewicz, James Moore, et al.

Journal article  |  2013  |  Clinical Cancer Research

Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents

Muling Mao, Feng Tian, John M Mariadason, Chun C Tsao, Robert Lemos, Farshid Dayyani, YN Vashisht Gopal, Zhi-Qin Jiang, Ignacio I Wistuba, Xi M Tang, William G Bornman, Gideon Bollag, Gordon B Mills, Garth Powis, Jayesh Desai, Gary E Gallick, Michael A Davies, Scott Kopetz

Journal article  |  2013  |  Clinical Cancer Research

Overview of biomarkers in metastatic colorectal cancer: Tumour, blood and patient-related factors

Stephen J Clarke, Christos S Karapetis, Peter Gibbs, Nick Pavlakis, Jayesh Desai, Michael Michael, Niall C Tebbutt, Tim J Price, Josep Tabernero

Journal article  |  2013  |  Critical Reviews in Oncology Hematology

SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer

Nicholas I Fleming, Robert N Jorissen, Dmitri Mouradov, Michael Christie, Anuratha Sakthianandeswaren, Michelle Palmieri, Fiona Day, Shan Li, Cary Tsui, Lara Lipton, Jayesh Desai, Ian T Jones, Stephen McLaughlin, Robyn L Ward, Nicholas J Hawkins, Andrew R Ruszkiewicz, James Moore, Hong-Jian Zhu, John M Mariadason, Antony W Burgess, et al.

Journal article  |  2013  |  Cancer Research

The past, present, and future of cytotoxic chemotherapy and pathway-directed targeted agents for soft tissue sarcoma.

Christopher W Ryan, Jayesh Desai

Journal article  |  2013  |  American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting

The individual rarity of the many subtypes of soft tissue sarcomas has historically mandated an empiric approach to systemic thera..

Soft-tissue Sarcomas in the Asia-Pacific Region: A Systematic Review

Roger Ngan, Edward Wang, David Porter, Jayesh Desai, Nugroho Prayogo, Beena Devi, Richard Quek

Journal article  |  2013  |  Asian Pacific Journal of Cancer Prevention

An initial watch and wait approach is a valid strategy for selected patients with newly diagnosed metastatic colorectal cancer

M Voskoboynik, S Bae, S Ananda, J Desai, S Kosmider, P Gibbs

Journal article  |  2012  |  Annals of Oncology

Phase II Study of Ganitumab, a Fully Human Anti-Type-1 Insulin-Like Growth Factor Receptor Antibody, in Patients With Metastatic Ewing Family Tumors or Desmoplastic Small Round Cell Tumors

William D Tap, George Demetri, Phillip Barnette, Jayesh Desai, Petr Kavan, Richard Tozer, Pasquale W Benedetto, Gregory Friberg, Hongjie Deng, Ian McCaffery, Ian Leitch, Sunita Badola, Sung Chang, Min Zhu, Anthony Tolcher

Journal article  |  2012  |  Journal of Clinical Oncology

Towards the biomarker-guided rational use of antiangiogenic agents in the treatment of metastatic colorectal cancer

Michael M Halford, Niall C Tebbutt, Jayesh Desai, Marc G Achen, Steven A Stacker

Journal article  |  2012  |  Colorectal Cancer

Outcomes of Patients With Maxillofacial Osteosarcoma: A Review of 15 Cases

Adrian F DeAngelis, Catherine Spinou, Alpha Tsui, Tim Iseli, Jayesh Desai, David Wiesenfeld, Arun Chandu

Journal article  |  2012  |  Journal of Oral and Maxillofacial Surgery

Dose optimization of tyrosine kinase inhibitors to improve outcomes in GIST

John R Zalcberg, Jayesh Desai

Journal article  |  2012  |  Asia Pacific Journal of Clinical Oncology

Microsatellite Instability Status Is Critical to Analysis of Survival in Stage II Colon Cancer

Susie Bae, Jeanne Tie, Jayesh Desai, Peter Gibbs

Journal article  |  2012  |  Journal of Clinical Oncology

Antiangiogenic therapies targeting the vascular endothelia growth factor signaling system.

Jeanne Tie, Jayesh Desai

Journal article  |  2012  |  Critical Reviews™ in Oncogenesis

Angiogenesis is critical to the growth of human tumors and the development of metastasis. Amongst the many proangiogenic mechanism..

Neurofibromatosis type 1-associated wild-type gastrointestinal stromal tumor treated with anti-IGF-1R monoclonal antibody

FL Day, J Desai, CL Corless, MC Heinrich, J Zalcberg

Journal article  |  2011  |  Medical Oncology

Impact of BRAF Mutation and Microsatellite Instability on the Pattern of Metastatic Spread and Prognosis in Metastatic Colorectal Cancer

Ben Tran, Scott Kopetz, Jeanne Tie, Peter Gibbs, Zhi-Qin Jiang, Christopher H Lieu, Atin Agarwal, Dipen M Maru, Oliver Sieber, Jayesh Desai

Journal article  |  2011  |  Cancer

Clinical, Pharmacodynamic, and Pharmacokinetic Evaluation of BNC105P: A Phase I Trial of a Novel Vascular Disrupting Agent and Inhibitor of Cancer Cell Proliferation

Danny Rischin, David C Bibby, Geoff Chong, Gabriel Kremmidiotis, Annabell F Leske, Clayton A Matthews, Shirley S Wong, Mark A Rosen, Jayesh Desai

Journal article  |  2011  |  Clinical Cancer Research

Safety and pharmacokinetics of motesanib in combination with gemcitabine and erlotinib for the treatment of solid tumors: a phase 1b study

Dusan Kotasek, Niall Tebbutt, Jayesh Desai, Stephen Welch, Lillian L Siu, Sheryl McCoy, Yu-Nien Sun, Jessica Johnson, Adeboye H Adewoye, Timothy Price

Journal article  |  2011  |  BMC Cancer

Optimising the management of soft tissue tumours

Chris Hemmings, Carina Miles, John Slavin, S Fiona Bonar, Nicole Graf, Lyn Austen, David Thomas, Jayesh Desai, Peter Barry

Journal article  |  2011  |  Pathology

Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation

Jeanne Tie, Peter Gibbs, Lara Lipton, Michael Christie, Robert N Jorissen, Antony W Burgess, Matthew Croxford, Ian Jones, Rachel Langland, Suzanne Kosmider, Daniel McKay, Gideon Bollag, Keith Nolop, Oliver M Sieber, Jayesh Desai

Journal article  |  2011  |  International Journal of Cancer

Response assessment in gastrointestinal stromal tumor

Jayesh Desai

Journal article  |  2011  |  International Journal of Cancer

KRAS Mutation Is Associated with Lung Metastasis in Patients with Curatively Resected Colorectal Cancer

Jeanne Tie, Lara Lipton, Jayesh Desai, Peter Gibbs, Robert N Jorissen, Michael Christie, Katharine J Drummond, Benjamin NJ Thomson, Valery Usatoff, Peter M Evans, Adrian W Pick, Simon Knight, Peter WG Carne, Roger Berry, Adrian Polglase, Paul McMurrick, Qi Zhao, Dana Busam, Robert L Strausberg, Enric Domingo, et al.

Journal article  |  2011  |  Clinical Cancer Research

Comprehensive Mapping of p53 Pathway Alterations Reveals an Apparent Role for Both SNP309 and MDM2 Amplification in Sarcomagenesis

Moriko Ito, Louise Barys, Terence O'Reilly, Sophie Young, Bella Gorbatcheva, John Monahan, Sabine Zumstein-Mecker, Peter F Choong, Ian Dickinson, Philip Crowe, Christine Hemmings, Jayesh Desai, David M Thomas, Joanna Lisztwan

Journal article  |  2011  |  Clinical Cancer Research

Analysis of cellular phosphatidylinositol (3,4,5)-trisphosphate levels and distribution using confocal fluorescent microscopy

Michelle Palmieri, Cameron J Nowell, Melanie Condron, James Gardiner, Andrew B Holmes, Jayesh Desai, Antony W Burgess, Bruno Catimel

Journal article  |  2010  |  Analytical Biochemistry

Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer

Robert N Jorissen, Peter Gibbs, Michael Christie, Saurabh Prakash, Lara Lipton, Jayesh Desai, David Kerr, Lauri A Aaltonen, Diego Arango, Mogens Kruhoffer, Torben F Orntoft, Claus Lindbjerg Andersen, Mike Gruidl, Vidya P Kamath, Steven Eschrich, Timothy J Yeatman, Oliver M Sieber

Journal article  |  2009  |  Clinical Cancer Research

DNA Copy-Number Alterations Underlie Gene Expression Differences between Microsatellite Stable and Unstable Colorectal Cancers

Robert N Jorissen, Lara Lipton, Peter Gibbs, Matthew Chapman, Jayesh Desai, Ian T Jones, Timothy J Yeatman, Philip East, Ian PM Tomlinson, Hein W Verspaget, Lauri A Aaltonen, Mogens Kruhoffer, Torben F Orntoft, Claus Lindbjerg Andersen, Oliver M Sieber

Journal article  |  2008  |  Clinical Cancer Research

Re: Residual Treatment Disparities After Oncology Referral for Rectal Cancer

Kathryn M Field, Suzanne Kosmider, Jayesh Desai, Lionel C Lim, Frances S Barnett, Stephen McLaughlin, Ian T Jones, Peter Gibbs

Journal article  |  2008  |  Journal of the National Cancer Institute

Consensus approaches to best practice management of gastrointestinal stromal tumors

John R Zalcberg, Jayesh Desai, Bruce Mann, Stephen Fox, David Goldstein, Grant Mcarthur, Matthew Clark, Desmond Yip

Journal article  |  2008  |  Asia-Pacific Journal of Clinical Oncology

Clinical Use of Therapies Targeting Tumor Vasculature and Stroma

Ian D Davis, Jayesh Desai

Journal article  |  2008  |  Current Cancer Drug Targets

Thyrotoxicosis during sunitinib treatment for renal cell carcinoma

Mathis Grossmann, Erosha Premaratne, Jayesh Desai, Ian D Davis

Journal article  |  2008  |  Clinical Endocrinology

Patient age and comorbidity are major determinants of adjuvant chemotherapy use for stage III colon cancer in routine clinical practice

Sumitra Ananda, Kathryn M Field, Suzanne Kosmider, Daniel Compston, Jayesh Desai, Lionel C Lim, Frances S Barnett, Ian T Jones, Iain Skinner, Peter Gibbs

Journal article  |  2008  |  Journal of Clinical Oncology

Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib

Tammy F Chu, Maria A Rupnick, Risto Kerkela, Susan M Dallabrida, David Zurakowski, Lisa Nguyen, Kathleen Woulfe, Elke Pravda, Flavia Cassiola, Jayesh Desai, Suzanne George, Jeffrey A Morgan, David M Harris, Nesreen S Ismail, Jey-Hsin Chen, Frederick J Schoen, Annick D Van den Abbeele, George D Demetri, Thomas Force, Ming Hui Chen

Journal article  |  2007  |  The Lancet

Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor

Anat Norden-Zfoni, Jayesh Desai, Judith Manola, Paul Beaudry, Jeremy Force, Robert Maki, Judah Folkman, Carlo Bello, Charles Baum, Sam E DePrimo, David R Shalinsky, Goerge D Demetri, John V Heymach

Journal article  |  2007  |  Clinical Cancer Research

Gemcitabine and vinorelbine combination chemotherapy for patients with advanced soft tissue sarcomas - Results of a phase II trial

Palma Dileo, Jeffrey A Morgan, David Zahrieh, Jayesh Desai, Jeanine M Salesi, David C Harrnon, M Travis Quigley, Kathleen Polson, George D Demetri, Suzanne George

Journal article  |  2007  |  Cancer

Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors

Jayesh Desai, Leila Yassa, Ellen Marqusee, Suzanne George, Mary C Frates, Ming Hui Chen, Jeffrey A Morgan, Samuel S Dychter, P Reed Larsen, George D Demetri, Erik K Alexander

Journal article  |  2006  |  Annals of Internal Medicine

Selective kinase inhibition with daily imatinib intensifies toxicity of chemotherapy in patients with solid tumours

Suzanne George, Jayesh Desai, J Paul Eder, Judith Manola, Dauid P Ryan, Leonard J Appleman, George D Demetri

Journal article  |  2006  |  European Journal of Cancer

Recombinant human erythropoietin in cancer-related anemia: an evidence-based review

J Desai, GD Demetri

Journal article  |  2005  |  Best Practice & Research: Clinical Haematology

Gastrointestinal stromal tumor: New nodule-within-a-mass pattern of recurrence after partial response to imatinib mesylate

S Shankar, E vanSonnenberg, J Desai, PJ DiPiro, A Van den Abbeele, GD Demetri

Journal article  |  2005  |  Radiology

Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas

JV Heymach, J Desai, J Manola, DW Davis, DJ McConkey, D Harmon, DP Ryan, G Goss, T Quigley, AD Van den Abbeele, SG Silverman, S Connors, J Folkman, CDM Fletcher, GD Demetri

Journal article  |  2004  |  Clinical Cancer Research

Management of gastrointestinal stromal tumors in the era of tyrosine kinase inhibitors.

Suzanne George, Jayesh Desai

Journal article  |  2002  |  Out of Date

Gastrointestinal stromal tumors (GIST) represent the most common type of mesenchymal malignancy in the gastrointestinal tract. Wit..

Safe administration of etoposide phosphate after hypersensitivity reaction to intravenous etoposide

J Siderov, P Prasad, R De Boer, J Desai

Journal article  |  2002  |  British Journal of Cancer