John Furness

Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin

Mengjie Liu, Emily A Whitfield, Linda J Fothergill, John B Furness, John D Wade, Sebastian GB Furness, Mohammed Akhter Hossain

Journal article  |  2020  |  Biochemical and Biophysical Research Communications

Human ghrelin receptor (GHSR) is a recognized prospective target in the diagnosis and therapy of multiple cancer types. To gain a ..

Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers

John B Furness, Ruslan Pustovit, Andrew J Syder, Mitchell T Ringuet, Eun Ji Yoo, Andrea Fanjul, Jill Wykosky, Linda J Fothergill, Emily A Whitfield, Sebastian GB Furness

Journal article  |  2020  |  Neurogastroenterology & Motility

BACKGROUND: Dopamine receptor 2 (DRD2) and ghrelin receptor (GHSR1a) agonists both stimulate defecation by actions at the lumbosac..

The effect of high-fat diet-induced metabolic disturbance on corneal neuroimmune features

Haihan Jiao, Alicia SL Lim, Therese E Fazio Coles, Rachel M McQuade, John B Furness, Holly R Chinnery

Journal article  |  2020  |  Experimental Eye Research

PURPOSE: The highly innervated cornea is susceptible to nerve loss secondary to systemic diseases such as diabetes and metabolic d..

The identification of neuronal control pathways supplying effector tissues in the stomach

John B Furness, Madeleine Di Natale, Billie Hunne, Lalita Oparija-Rogenmozere, Sean M Ward, Kent C Sasse, Terry L Powley, Martin J Stebbing, Deborah Jaffey, Linda J Fothergill

Journal article  |  2020  |  Cell and Tissue Research

The stomach acts as a buffer between the ingestion of food and its processing in the small intestine. It signals to the brain to m..

Betaine and Isoquinoline Alkaloids Protect against Heat Stress and Colonic Permeability in Growing Pigs

Hieu Huu Le, Majid Shakeri, Hafiz Ansar Rasul Suleria, Weicheng Zhao, Rachel Mai McQuade, Deborah Jayne Phillips, Eva Vidacs, John Barton Furness, Frank Rowland Dunshea, Valeria Artuso-Ponte, Jeremy James Cottrell

Journal article  |  2020  |  Antioxidants

Heat stress (HS) compromises productivity of pork production, in part as a result of increased oxidative stress and inflammatory r..

Three-dimensional grow of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

CheukMan C Au, John B Furness, Kara Britt, Sofya Oshchepkova, Heta Ladumor, Kai Ying Soo, Brid Callaghan, Celine Gerard, Giorgio Inghirami, Vivek Mittal, Yufeng Wang, Xin Yun Huang, Jason A Spector, Eleni Andreopoulou, Paul Zumbo, Doron Betel, Lukas Dow, Kristy A Brown

Journal article  |  2020  |  eLife

Breast cancer is the most common type of cancer in women and notwithstanding important therapeutic advances, remains the second le..

Investigation of nerve pathways mediating colorectal dysfunction in Parkinson's disease model produced by lesion of nigrostriatal dopaminergic neurons

Xin-yi Chai, Shanti Diwakarla, Ruslan V Pustovit, Rachel M McQuade, Madeleine Di Natale, Charlotte M Ermine, Clare L Parish, David I Finkelstein, John B Furness

Journal article  |  2020  |  Neurogastroenterology & Motility

BACKGROUND: Gastrointestinal (GI) dysfunction, including constipation, is a common non-motor symptom of Parkinson's disease (PD). ..

A new algorithm for drift compensation in multi-unit recordings of action potentials in peripheral autonomic nerves over time.

Catherine E Davey, Artemio Soto-Breceda, Anthony Shafton, Robin M McAllen, John B Furness, David B Grayden, Martin J Stebbing

Journal article  |  2020  |  Journal of Neuroscience Methods

BACKGROUND: Peripheral autonomic nerves control visceral organs and convey information regarding their functional states and are, ..

Colokinetic effect of an insulin-like peptide 5-related agonist of the RXFP4 receptor

Shanti Diwakarla, Ross AD Bathgate, Xiaozhou Zhang, Mohammed Akhter Hossain, John B Furness

Journal article  |  2020  |  Neurogastroenterology & Motility

BACKGROUND: Insulin-like peptide 5 (INSL5) is a hormone stored in colonic enteroendocrine cells that also contain the unrelated ho..

Effects and sites of action of a M1 receptor positive allosteric modulator on colonic motility in rats and dogs compared with 5-HT4 agonism and cholinesterase inhibition

Yasuhiro Tsukimi, Ruslan V Pustovit, Andrea M Harrington, Sonia Garcia-Caraballo, Stuart M Brierley, Madeleine Di Natale, Juan C Molero, John B Furness

Journal article  |  2020  |  Neurogastroenterology & Motility

BACKGROUND: Muscarinic receptor 1 positive allosteric modulators (M1PAMs) enhance colonic propulsive contractions and defecation t..