John Furness

Autonomic neuromuscular junctions.

Madeleine R Di Natale, Martin J Stebbing, John B Furness

Journal article  |  2021  |  Autonomic Neuroscience

This review traces the history of the discovery and subsequent understanding of smooth muscle cells and their motor innervation. S..

Analysis of Bioavailability and Induction of Glutathione Peroxidase by Dietary Nanoelemental, Organic and Inorganic Selenium

Mitchell T Ringuet, Billie Hunne, Markus Lenz, David M Bravo, John B Furness

Journal article  |  2021  |  Nutrients

Dietary organic selenium (Se) is commonly utilized to increase formation of selenoproteins, including the major antioxidant protei..

5-HT containing enteroendocrine cells characterised by morphologies, patterns of hormone co-expression, and relationships with nerve fibres in the mouse gastrointestinal tract

Ada Koo, Linda J Fothergill, Hirofumi Kuramoto, John B Furness

Journal article  |  2021  |  Histochemistry and Cell Biology

5-HT containing enteroendocrine cells (EEC), the most abundant type of EEC in the gut, regulate many functions including motility,..

Morphologies and distributions of 5-HT containing enteroendocrine cells in the mouse large intestine

Hirofumi Kuramoto, Ada Koo, Linda J Fothergill, Billie Hunne, Ryoichi Yoshimura, Makoto Kadowaki, John B Furness

Journal article  |  2021  |  Cell and Tissue Research

Serotonin (5-HT)-containing gastrointestinal endocrine cells contribute to regulation of numerous bodily functions, but whether th..

Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin

Mengjie Liu, Emily A Whitfield, Linda J Fothergill, John B Furness, John D Wade, Sebastian GB Furness, Mohammed Akhter Hossain

Journal article  |  2020  |  Biochemical and Biophysical Research Communications

Human ghrelin receptor (GHSR) is a recognized prospective target in the diagnosis and therapy of multiple cancer types. To gain a ..

Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers

John B Furness, Ruslan Pustovit, Andrew J Syder, Mitchell T Ringuet, Eun Ji Yoo, Andrea Fanjul, Jill Wykosky, Linda J Fothergill, Emily A Whitfield, Sebastian GB Furness

Journal article  |  2020  |  Neurogastroenterology & Motility

BACKGROUND: Dopamine receptor 2 (DRD2) and ghrelin receptor (GHSR1a) agonists both stimulate defecation by actions at the lumbosac..

The effect of high-fat diet-induced metabolic disturbance on corneal neuroimmune features

Haihan Jiao, Alicia SL Lim, Therese E Fazio Coles, Rachel M McQuade, John B Furness, Holly R Chinnery

Journal article  |  2020  |  Experimental Eye Research

PURPOSE: The highly innervated cornea is susceptible to nerve loss secondary to systemic diseases such as diabetes and metabolic d..

The identification of neuronal control pathways supplying effector tissues in the stomach

John B Furness, Madeleine Di Natale, Billie Hunne, Lalita Oparija-Rogenmozere, Sean M Ward, Kent C Sasse, Terry L Powley, Martin J Stebbing, Deborah Jaffey, Linda J Fothergill

Journal article  |  2020  |  Cell and Tissue Research

The stomach acts as a buffer between the ingestion of food and its processing in the small intestine. It signals to the brain to m..

Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson's Disease

Christine L West, Yu-Kang Mao, Thilini Delungahawatta, Jessica Y Amin, Sohana Farhin, Rachel M McQuade, Shanti Diwakarla, Ruslan Pustovit, Andrew M Stanisz, John Bienenstock, Denise Barbut, Michael Zasloff, John B Furness, Wolfgang A Kunze

Journal article  |  2020  |  Journal of Parkinson's Disease

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder thought to be caused by accumulation of α-synucle..

Betaine and Isoquinoline Alkaloids Protect against Heat Stress and Colonic Permeability in Growing Pigs

Hieu Huu Le, Majid Shakeri, Hafiz Ansar Rasul Suleria, Weicheng Zhao, Rachel Mai McQuade, Deborah Jayne Phillips, Eva Vidacs, John Barton Furness, Frank Rowland Dunshea, Valeria Artuso-Ponte, Jeremy James Cottrell

Journal article  |  2020  |  Antioxidants

Heat stress (HS) compromises productivity of pork production, in part as a result of increased oxidative stress and inflammatory r..