Helen Thomas

Enhanced structure and function of human pluripotent stem cell-derived beta-cells cultured on extracellular matrix.

Reena Singh, Louise Cottle, Thomas Loudovaris, Di Xiao, Pengyi Yang, Helen E Thomas, Melkam A Kebede, Peter Thorn

Journal article  |  2021  |  Stem Cells Transl Med

The differentiation of human stem cells into insulin secreting beta-like cells holds great promise to treat diabetes. Current prot..

The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-gamma and Common gamma Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice

Tingting Ge, Gaurang Jhala, Stacey Fynch, Satoru Akazawa, Sara Litwak, Evan G Pappas, Tara Catterall, Ishan Vakil, Andrew J Long, Lisa M Olson, Balasubramanian Krishnamurthy, Thomas W Kay, Helen E Thomas

Journal article  |  2020  |  FRONTIERS IN IMMUNOLOGY

Cytokines that signal through the JAK-STAT pathway, such as interferon-γ (IFN-γ) and common γ chain cytokines, contribute to the d..

IL-17F induces inflammation, dysfunction and cell death in mouse islets

Tara Catterall, Stacey Fynch, Thomas WH Kay, Helen E Thomas, Andrew PR Sutherland

Journal article  |  2020  |  SCIENTIFIC REPORTS

Type 17 immune responses, typified by the production of the cytokines IL-17A and IL-17F, have been implicated in the development o..

A fluorescent timer reporter enables sorting of insulin secretory granules by age.

Belinda Yau, Lori Hays, Cassandra Liang, D Ross Laybutt, Helen E Thomas, Jenny E Gunton, Lindy Williams, Wayne J Hawthorne, Peter Thorn, Christopher J Rhodes, Melkam A Kebede

Journal article  |  2020  |  J Biol Chem

Within the pancreatic β-cells, insulin secretory granules (SGs) exist in functionally distinct pools, displaying variations in mot..

E2f8 and Dlg2 genes have independent effects on impaired insulin secretion associated with hyperglycaemia

Chieh-Hsin Yang, Salvatore P Mangiafico, Michaela Waibel, Thomas Loudovaris, Kim Loh, Helen E Thomas, Grant Morahan, Sofianos Andrikopoulos

Journal article  |  2020  |  DIABETOLOGIA

AIMS/HYPOTHESIS: Reduced insulin secretion results in hyperglycaemia and diabetes involving a complex aetiology that is yet to be ..

ABCA12 regulates insulin secretion from beta-cells

Gloria M Ursino, Ying Fu, Denny L Cottle, Nigora Mukhamedova, Lynelle K Jones, Hann Low, Ming Shen Tham, Wan Jun Gan, Natalie A Mellett, Partha P Das, Jacquelyn M Weir, Michael Ditiatkovski, Stacey Fynch, Peter Thorn, Helen E Thomas, Peter J Meikle, Helena C Parkington, Ian M Smyth, Dmitri Sviridov

Journal article  |  2020  |  EMBO REPORTS

Dysregulation of lipid homeostasis is intimately associated with defects in insulin secretion, a key feature of type 2 diabetes. H..

Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans.

Mohammed Bensellam, Yan-Chuan Shi, Jeng Yie Chan, D Ross Laybutt, Heeyoung Chae, Michel Abou-Samra, Evan G Pappas, Helen E Thomas, Patrick Gilon, Jean-Christophe Jonas

Journal article  |  2019  |  Diabetologia

AIMS/HYPOTHESIS: The mechanisms responsible for beta cell compensation in obesity and for beta cell failure in type 2 diabetes are..

IL-21 regulates SOCS1 expression in autoreactive CD8( ) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice

Andrew PR Sutherland, Kate L Graham, Michelle Papadimitriou, Gaurang Jhala, Prerak Trivedi, Tara Catterall, Stacey Fynch, Thomas WH Kay, Helen E Thomas

Journal article  |  2019  |  SCIENTIFIC REPORTS

In type 1 diabetes, maturation of activated autoreactive CD8+ T cells to fully armed effector cytotoxic T lymphocytes (CTL) occurs..

Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice

Prerak M Trivedi, Stacey Fynch, Lucy M Kennedy, Jonathan Chee, Balasubramanian Krishnamurthy, Lorraine A O'Reilly, Andreas Strasser, Thomas WH Kay, Helen E Thomas

Journal article  |  2019  |  CELL DEATH DISCOVERY

CD8+ T cells play a central role in beta-cell destruction in type 1 diabetes. CD8+ T cells use two main effector pathways to kill ..

Phlda3 regulates beta cell survival during stress.

Mohammed Bensellam, Jeng Yie Chan, Kailun Lee, Mugdha V Joglekar, Anandwardhan A Hardikar, Thomas Loudovaris, Helen E Thomas, Jean-Christophe Jonas, D Ross Laybutt

Journal article  |  2019  |  Sci Rep

The loss of functional beta cell mass characterises all forms of diabetes. Beta cells are highly susceptible to stress, including ..