Helen Thomas

E2f8 and Dlg2 genes have independent effects on impaired insulin secretion associated with hyperglycaemia

Chieh-Hsin Yang, Salvatore P Mangiafico, Michaela Waibel, Thomas Loudovaris, Kim Loh, Helen E Thomas, Grant Morahan, Sofianos Andrikopoulos

Journal article  |  2020  |  Diabetologia

AIMS/HYPOTHESIS: Reduced insulin secretion results in hyperglycaemia and diabetes involving a complex aetiology that is yet to be ..

Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans.

Mohammed Bensellam, Yan-Chuan Shi, Jeng Yie Chan, D Ross Laybutt, Heeyoung Chae, Michel Abou-Samra, Evan G Pappas, Helen E Thomas, Patrick Gilon, Jean-Christophe Jonas

Journal article  |  2019  |  Diabetologia

AIMS/HYPOTHESIS: The mechanisms responsible for beta cell compensation in obesity and for beta cell failure in type 2 diabetes are..

IL-21 regulates SOCS1 expression in autoreactive CD8( ) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice

Andrew PR Sutherland, Kate L Graham, Michelle Papadimitriou, Gaurang Jhala, Prerak Trivedi, Tara Catterall, Stacey Fynch, Thomas WH Kay, Helen E Thomas

Journal article  |  2019  |  Scientific Reports

In type 1 diabetes, maturation of activated autoreactive CD8+ T cells to fully armed effector cytotoxic T lymphocytes (CTL) occurs..

Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice

Prerak M Trivedi, Stacey Fynch, Lucy M Kennedy, Jonathan Chee, Balasubramanian Krishnamurthy, Lorraine A O'Reilly, Andreas Strasser, Thomas WH Kay, Helen E Thomas

Journal article  |  2019  |  Cell Death Discovery

CD8+ T cells play a central role in beta-cell destruction in type 1 diabetes. CD8+ T cells use two main effector pathways to kill ..

Phlda3 regulates beta cell survival during stress.

Mohammed Bensellam, Jeng Yie Chan, Kailun Lee, Mugdha V Joglekar, Anandwardhan A Hardikar, Thomas Loudovaris, Helen E Thomas, Jean-Christophe Jonas, D Ross Laybutt

Journal article  |  2019  |  Scientific Reports

The loss of functional beta cell mass characterises all forms of diabetes. Beta cells are highly susceptible to stress, including ..

Replica moulded poly(dimethylsiloxane) microwell arrays induce localized endothelial cell immobilization for coculture with pancreatic islets

Anouck LS Burzava, Aurelien Forget, Frances J Harding, Michaelia P Cockshell, Daniella Penko, Camille Rouzaud, Vincent Ahmadi, Paula F Marina, Darling Rojas-Canales, Claudine S Bonder, P Toby H Coates, Michaela Waibel, Helen E Thomas, Thomas W Kay, Thomas Loudovaris, Anton Blencowe, Nicolas H Voelcker

Journal article  |  2019  |  Biointerphases

Replacing murine insulin 1 with human insulin protects NOD mice from diabetes.

Colleen M Elso, Nicholas A Scott, Lina Mariana, Emma I Masterman, Andrew PR Sutherland, Helen E Thomas, Stuart I Mannering

Journal article  |  2019  |  PLOS ONE

Type 1, or autoimmune, diabetes is caused by the T-cell mediated destruction of the insulin-producing pancreatic beta cells. Non-o..

IFN gamma-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4( ) T Cell Migration

Nicholas A Scott, Yuxing Zhao, Balasubramanian Krishnamurthy, Stuart I Mannering, Thomas WH Kay, Helen E Thomas

Journal article  |  2018  |  Frontiers in Immunology

Proinsulin C-peptide is an autoantigen in people with type 1 diabetes

Michelle So, Colleen M Elso, Eleonora Tresoldi, Miha Pakusch, Vimukthi Pathiraja, John M Wentworth, Leonard C Harrison, Balasubramanian Krishnamurthy, Helen E Thomas, Christine Rodda, Fergus J Cameron, Jacinta McMahon, Thomas WH Kay, Stuart I Mannering

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Type I Interferon Signaling Is Required for Dacryoadenitis in the Nonobese Diabetic Mouse Model of Sjogren Syndrome

Yury Chaly, Jennifer Y Barr, David A Sullivan, Helen E Thomas, Thomas C Brodnicki, Scott M Lieberman

Journal article  |  2018  |  International Journal of Molecular Sciences

Expression of miR-206 in human islets and its role in glucokinase regulation.

Mugdha V Joglekar, Wilson KM Wong, Cody-Lee Maynard, Malati R Umrani, David Martin, Thomas Loudovaris, Helen E Thomas, Louise T Dalgaard, Anandwardhan A Hardikar

Journal article  |  2018  |  American Journal of Physiology-Endocrinology and Metabolism

Inappropriate insulin secretion from β-cells is considered as an early sign of impaired glucose tolerance and type 2 diabetes (T2D..

Australian Experience of Total Pancreatectomy and Islet Auto Transplant (TPIAT) Utilizing a Remote Isolation Center

Chris Drogemuller, Toni Radford, Chris Russell, John Chen, Sanjeev Khurana, David Torpy, Jennifer Couper, Richard Couper, Cameron Kos, Nicole Bleasdale, Helen Thomas, Allison Irvin, Tom Kay, Lina Mariana, Thomas Loudovaris, Toby Coates

Conference Proceedings  |  2018  |  Transplantation

Prevention of Islet Inflammatory Stress with JAK1/JAK2 Inhibitors

Eleanor Watson, Michaela Waibel, Prerak Trivedi, Evan Pappas, Stacey Fynch, Robyn Sutherland, Thomas Kay, Helen Thomas

Conference Proceedings  |  2018  |  Transplantation

NF-kappa B is weakly activated in the NOD mouse model of type 1 diabetes

Allison E Irvin, Gaurang Jhala, Yuxing Zhao, Timothy S Blackwell, Balasubramanian Krishnamurthy, Helen E Thomas, Thomas WH Kay

Journal article  |  2018  |  Scientific Reports

Oxygen-permeable microwell device maintains islet mass and integrity during shipping

Darling M Rojas-Canales, Michaela Waibel, Aurelien Forget, Daniella Penko, Jodie Nitschke, Fran J Harding, Bahman Delalat, Anton Blencowe, Thomas Loudovaris, Shane T Grey, Helen E Thomas, Thomas WH Kay, Chris J Drogemuller, Nicolas H Voelcker, Patrick T Coates

Journal article  |  2018  |  Endocrine Connections

Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans

Charmaine J Simeonovic, Sarah K Popp, Lora M Starrs, Debra J Brown, Andrew F Ziolkowski, Barbara Ludwig, Stefan R Bornstein, J Dennis Wilson, Alberto Pugliese, Thomas WH Kay, Helen E Thomas, Thomas Loudovaris, Fui Jiun Choong, Craig Freeman, Christopher R Parish

Journal article  |  2018  |  PLOS ONE

Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice

Jibran A Wali, Sandra Galic, Christina YR Tan, Esteban N Gurzov, Ann E Frazier, Timothy Connor, Jingjing Ge, Evan G Pappas, David Stroud, L Chitra Varanasi, Claudia Selck, Michael T Ryan, David R Thorburn, Bruce E Kemp, Balasubramanian Krishnamurthy, Thomas WH Kay, Sean L Mcgee, Helen E Thomas

Journal article  |  2018  |  Cell Death & Differentiation

Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice.

Jibran A Wali, Sandra Galic, Christina Yr Tan, Esteban N Gurzov, Ann E Frazier, Timothy Connor, Jingjing Ge, Evan G Pappas, David Stroud, L Chitra Varanasi, Claudia Selck, Michael T Ryan, David R Thorburn, Bruce E Kemp, Balasubramanian Krishnamurthy, Thomas Wh Kay, Sean L McGee, Helen E Thomas

Journal article  |  2018  |  Cell death and differentiation

BCL-2 proteins are known to engage each other to determine the fate of a cell after a death stimulus. However, their evolutionary ..

Characterization of the Human Pancreas Side Population as a Potential Reservoir of Adult Stem Cells

Petra Augstein, Thomas Loudovaris, Esther Bandala-Sanchez, Peter Heinke, Gaetano Naselli, Lily Lee, Wayne J Hawthorne, L Jorge Gonez, Alana M Neale, Francois Vaillant, Helen E Thomas, Thomas W Kay, Ilia Banakh, Leonard C Harrison

Journal article  |  2018  |  Pancreas

JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity

Sara A Litwak, Lokman Pang, Sandra Galic, Mariana Igoillo-Esteve, William J Stanley, Jean-Valery Turatsinze, Kim Loh, Helen E Thomas, Arpeeta Sharma, Eric Trepo, Christophe Moreno, Daniel J Gough, Decio L Eizirik, Judy B de Haan, Esteban N Gurzov

Journal article  |  2017  |  Diabetes

The members of the BCL-2 family are crucial regulators of the mitochondrial pathway of apoptosis in normal physiology and disease...

Differential regulation of pro-inflammatory cytokine signalling by protein tyrosine phosphatases in pancreatic β-cells.

William J Stanley, Prerak M Trivedi, Andrew P Sutherland, Helen E Thomas, Esteban N Gurzov

Journal article  |  2017  |  Journal of Molecular Endocrinology

Type 1 diabetes (T1D) is characterized by the destruction of insulin-producing β-cells by immune cells in the pancreas. Pro-inflam..

Transplantation sites for human and murine islets

Rebecca A Stokes, Kim Cheng, Amit Lalwani, Michael M Swarbrick, Helen E Thomas, Thomas Loudovaris, Tom W Kay, Wayne J Hawthorne, Philip J O'Connell, Jenny E Gunton

Journal article  |  2017  |  Diabetologia

Inhibition of Y1 receptor signaling improves islet transplant outcome

Kim Loh, Yan-Chuan Shi, Stacey Walters, Mohammed Bensellam, Kailun Lee, Katsuya Dezaki, Masanori Nakata, Chi Kin Ip, Jeng Yie Chan, Esteban N Gurzov, Helen E Thomas, Michaela Waibel, James Cantley, Thomas W Kay, Toshihiko Yada, D Ross Laybutt, Shane T Grey, Herbert Herzog

Journal article  |  2017  |  Nature Communications

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice

Prerak M Trivedi, Kate L Graham, Nicholas A Scott, Misty R Jenkins, Suktilang Majaw, Robyn M Sutherland, Stacey Fynch, Andrew M Lew, Christopher J Burns, Balasubramanian Krishnamurthy, Thomas C Brodnicki, Stuart I Mannering, Thomas W Kay, Helen E Thomas

Journal article  |  2017  |  Diabetes

Non-invasive, in vitro analysis of islet insulin production enabled by an optical porous silicon biosensor

Rinku Chhasatia, Martin J Sweetman, Frances J Harding, Michaela Waibel, Tom Kay, Helen Thomas, Thomas Loudovaris, Nicolas H Voelcker

Journal article  |  2017  |  Biosensors and Bioelectronics

Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility

Edward PF Chu, Colleen M Elso, Abigail H Pollock, May A Alsayb, Leanne Mackin, Helen E Thomas, Thomas WH Kay, Pablo A Silveira, Ashley S Mansell, Katharina Gaus, Thomas C Brodnicki

Journal article  |  2017  |  Molecular Immunology

Genetic strategies to bring islet xenotransplantation to the clinic

Wayne J Hawthorne, Andrew M Lew, Helen E Thomas

Journal article  |  2016  |  Current Opinion in Organ Transplantation

The JAK/STAT pathway in obesity and diabetes.

Esteban N Gurzov, William J Stanley, Evan G Pappas, Helen E Thomas, Daniel J Gough

Journal article  |  2016  |  The FEBS Journal

Diabetes mellitus are complex, multi-organ metabolic pathologies characterized by hyperglycemia. Emerging evidence shows that the ..

Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes

Gaurang Jhala, Jonathan Chee, Prerak M Trivedi, Claudia Selck, Esteban N Gurzov, Kate L Graham, Helen E Thomas, Thomas WH Kay, Balasubramanian Krishnamurthy

Journal article  |  2016  |  JCI Insight

How to Make Mice Tell the Truth

Helen E Thomas, Thomas C Brodnicki, Thomas WH Kay

Journal article  |  2016  |  Diabetes

Human islet cells are killed by BID-independent mechanisms in response to FAS ligand

Mugdha V Joglekar, Prerak M Trivedi, Thomas W Kay, Wayne J Hawthorne, Philip J O'Connell, Alicia J Jenkins, Anandwardhan A Hardikar, Helen E Thomas

Journal article  |  2016  |  Apoptosis

p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.

Sara A Litwak, Kim Loh, William J Stanley, Evan G Pappas, Jibran A Wali, Claudia Selck, Andreas Strasser, Helen E Thomas, Esteban N Gurzov

Journal article  |  2016  |  Scientific Reports

Perforin facilitates beta cell killing and regulates autoreactive CD8( ) T-cell responses to antigen in mouse models of type 1 diabetes

Prerak Trivedi, Kate L Graham, Balasubramaninan Krishnamurthy, Stacey Fynch, Robyn M Slattery, Thomas Wh Kay, Helen E Thomas

Journal article  |  2016  |  Immunology & Cell Biology

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Prerak Trivedi, Tara Catterall, Claudia Selck, Esteban N Gurzov, Thomas C Brodnicki, Kate L Graham, Jibran A Wali, Yifan Zhan, Daniel Gray, Andreas Strasser, Janette Allison, Helen E Thomas, Thomas WH Kay

Journal article  |  2015  |  Diabetes

Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets

William J Stanley, Sara A Litwak, Hong Sheng Quah, Sih Min Tan, Thomas WH Kay, Tony Tiganis, Judy B de Haan, Helen E Thomas, Esteban N Gurzov

Journal article  |  2015  |  Diabetes

Pancreatic Alpha Cells Hold the Key to Survival.

Jibran A Wali, Helen E Thomas

Journal article  |  2015  |  EBioMedicine

Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes

Yuxing Zhao, Nicholas A Scott, Stacey Fynch, Lorraine Elkerbout, W Wei-Lynn Wong, Kylie D Mason, Andreas Strasser, David C Huang, Thomas WH Kay, Helen E Thomas

Journal article  |  2015  |  Diabetologia

Lipotoxic Stress Induces Pancreatic beta-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System

Sara A Litwak, Jibran A Wali, Evan G Pappas, Hamdi Saadi, William J Stanley, L Chitra Varanasi, Thomas WH Kay, Helen E Thomas, Esteban N Gurzov

Journal article  |  2015  |  Journal of Diabetes Research

Measuring Death of Pancreatic Beta Cells in Response to Stress and Cytotoxic T Cells

Jibran A Wali, Prerak Trivedi, Thomas W Kay, Helen E Thomas

Book Chapter  |  2015  |  Methods in Molecular Biology

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

Sumaira Z Hasnain, Danielle J Borg, Brooke E Harcourt, Hui Tong, Yonghua H Sheng, Choa Ping Ng, Indrajit Das, Ran Wang, Alice C-H Chen, Thomas Loudovaris, Thomas W Kay, Helen E Thomas, Jonathan P Whitehead, Josephine M Forbes, Johannes B Prins, Michael A McGuckin

Journal article  |  2014  |  Nature Medicine

Activation of the NLRP3 Inflammasome Complex is Not Required for Stress-Induced Death of Pancreatic Islets

Jibran A Wali, Esteban N Gurzov, Stacey Fynch, Lorraine Elkerbout, Thomas W Kay, Seth L Masters, Helen E Thomas

Journal article  |  2014  |  PLoS ONE

Functional cytotoxic T lymphocytes against IGRP(206-214) predict diabetes in the non-obese diabetic mouse

Hyun-Ja Ko, Jonathan Chee, Robyn M Sutherland, Helen E Thomas, Yifan Zhan, Balasubrarnanian Krishnamurthy, Thomas WH Kay, Andrew M Lew

Journal article  |  2014  |  Immunology & Cell Biology

Linking obesity with type 2 diabetes: The role of T-bet

JA Wali, HE Thomas, APR Sutherland

Journal article  |  2014  |  Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice

Hong Sheng Quah, Socorro Miranda-Hernandez, Aimee Khoo, Ashley Harding, Stacey Fynch, Lorraine Elkerbout, Thomas C Brodnicki, Alan G Baxter, Thomas WH Kay, Helen E Thomas, Kate L Graham

Journal article  |  2014  |  Diabetes

The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity

JA Wali, D Rondas, MD McKenzie, Y Zhao, L Elkerbout, S Fynch, EN Gurzov, S Akira, C Mathieu, TWH Kay, L Overbergh, A Strasser, HE Thomas

Journal article  |  2014  |  Cell Death & Disease

Effector-Memory T Cells Develop in Islets and Report Islet Pathology in Type 1 Diabetes

Jonathan Chee, Hyun-Ja Ko, Ania Skowera, Gaurang Jhala, Tara Catterall, Kate L Graham, Robyn M Sutherland, Helen E Thomas, Andrew M Lew, Mark Peakman, Thomas WH Kay, Balasubramanian Krishnamurthy

Journal article  |  2014  |  The Journal of Immunology

The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin-Induced Diabetes in Mice

Joanne SJ Chia, Jennifer L McRae, Helen E Thomas, Stacey Fynch, Lorraine Elkerbout, Prue Hill, Lisa Murray-Segal, Simon C Robson, Jiang-Fan Chen, Anthony JF d'Apice, Peter J Cowan, Karen M Dwyer

Journal article  |  2013  |  Diabetes

Proinflammatory cytokines contribute to development and function of regulatory T cells in type 1 diabetes

Helen E Thomas, Kate L Graham, Jonathan Chee, Ranjeny Thomas, Thomas W Kay, Balasubramanian Krishnamurthy

Journal article  |  2013  |  Annals of The New York Academy of Sciences

Granzyme B Is Dispensable in the Development of Diabetes in Non-Obese Diabetic Mice

Zia U Mollah, Kate L Graham, Balasubramanian Krishnamurthy, Prerak Trivedi, Thomas C Brodnicki, Joseph A Trapani, Thomas W Kay, Helen E Thomas

Journal article  |  2012  |  PLoS One

Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors

Max Joffe, Andra S Necula, Rochna Chand, Brett C McWhinney, Balasubramanian Krishnamurthy, Tom Loudovaris, David Goodman, Helen E Thomas, Thomas WH Kay, Stuart I Mannering

Journal article  |  2012  |  International Immunology

Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression

Kate L Graham, Balasubramanian Krishnamurthy, Stacey Fynch, Rochelle Ayala-Perez, Robyn M Slattery, Pere Santamaria, Helen E Thomas, Thomas WH Kay

Journal article  |  2012  |  European Journal of Immunology

An indirect role for NK cells in a CD4( ) T-cell-dependent mouse model of type I diabetes

Eveline Angstetra, Kate L Graham, Yuxing Zhao, Allison E Irvin, Lorraine Elkerbout, Pere Santamaria, Robyn M Slattery, Thomas W Kay, Helen E Thomas

Journal article  |  2012  |  Immunology and Cell Biology

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells

Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Stacey Fynch, Kate L Graham, Pere Santamaria, Grant Morahan, Janette Allison, David Izon, Helen E Thomas, Thomas WH Kay

Journal article  |  2012  |  Diabetes

Expression of Pro- and Antiapoptotic Molecules of the Bcl-2 Family in Human Islets Postisolation

Peter D Campbell, Anita Weinberg, Jonathan Chee, Lina Mariana, Rochelle Ayala, Wayne J Hawthorne, Philip J O'Connell, Thomas Loudovaris, Mark J Cowley, Thomas W Kay, Shane T Grey, Helen E Thomas

Journal article  |  2012  |  Cell Transplantation

Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.

Kate L Graham, Robyn M Sutherland, Stuart I Mannering, Yuxing Zhao, Jonathan Chee, Balasubramanian Krishnamurthy, Helen E Thomas, Andrew M Lew, Thomas WH Kay

Journal article  |  2012  |  The Review of Diabetic Studies

Recent advances in our understanding of the pathogenesis of type 1 diabetes have occurred in all steps of the disease. This review..

TNF Receptor 1 Deficiency Increases Regulatory T Cell Function in Nonobese Diabetic Mice

Jonathan Chee, Eveline Angstetra, Lina Mariana, Kate L Graham, Emma M Carrington, Horst Bluethmann, Pere Santamaria, Janette Allison, Thomas WH Kay, Balasubramanian Krishnamurthy, Helen E Thomas

Journal article  |  2011  |  Journal of Immunology

The pro-apoptotic BH3-only protein Bid is dispensable for development of insulitis and diabetes in the non-obese diabetic mouse

Zia UA Mollah, Jibran Wali, Mark D McKenzie, Balasubramanian Krishnamurthy, Kate L Graham, Stacey Fynch, Joshua Szanyi, Pere Santamaria, Thomas Brodnicki, Janette Allison, Andreas Strasser, Thomas WH Kay, Helen E Thomas

Journal article  |  2011  |  Apoptosis

Autoreactive Cytotoxic T Lymphocytes Acquire Higher Expression of Cytotoxic Effector Markers in the Islets of NOD Mice after Priming in Pancreatic Lymph Nodes

Kate L Graham, Balasubramanian Krishnamurthy, Stacey Fynch, Zia U Mollah, Robyn Slattery, Pere Santamaria, Thomas W Kay, Helen E Thomas

Journal article  |  2011  |  American Journal of Pathology

A method for extracting tissue proteins for use in lymphocyte function assays

Hayley C Moon, Max Joffe, Helen E Thomas, Thomas WH Kay, Stuart I Mannering

Journal article  |  2010  |  Journal of Immunological Methods

The role of perforin and granzymes in diabetes

HE Thomas, JA Trapani, TWH Kay

Journal article  |  2010  |  Cell Death & Differentiation

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax

Mark D McKenzie, Emma Jamieson, Elisa S Jansen, Clare L Scott, David CS Huang, Philippe Bouillet, Janette Allison, Thomas WH Kay, Andreas Strasser, Helen E Thomas

Journal article  |  2010  |  Diabetes

In vivo effects of cytokines on pancreatic beta-cells in models of type I diabetes dependent on CD4( ) T lymphocytes

Eveline Angstetra, Kate L Graham, Sarah Emmett, Nadine L Dudek, Rima Darwiche, Rochelle Ayala-Perez, Janette Allison, Pere Santamaria, Thomas WH Kay, Helen E Thomas

Journal article  |  2009  |  Immunology and Cell Biology

Cytotoxic T-lymphocyte-mediated killing of human pancreatic islet cells in vitro

Peter D Campbell, Eugene Estella, Nadine L Dudek, Gaurang Jhala, Helen E Thomas, Thomas WH Kay, Stuart I Mannering

Journal article  |  2008  |  Human Immunology

Proapoptotic BH3-only protein bid is essential for death receptor-induced apoptosis of pancreatic beta-cells

Mark D McKenzie, Emma M Carrington, Thomas Kaufmann, Andreas Strasser, David CS Huang, Thomas WH Kay, Janette Allison, Helen E Thomas

Journal article  |  2008  |  Diabetes

Autoimmunity to both proinsulin and IGRP is required for diabetes in nonobese diabetic 8.3 TCR transgenic mice

Balasubramanian Krishnamurthy, Lina Mariana, Shane A Gellert, Peter G Colman, Leonard C Harrison, Andrew M Lew, Pere Santamaria, Helen E Thomas, Thomas WH Kay

Journal article  |  2008  |  Journal of Immunology

Cytotoxic T cell mechanisms of beta cell destruction in non-obese diabetic mice.

Thomas WH Kay, Nadine L Dudek, Kate Graham, Eugene Estella, Eveline Angstetra, Mark D McKenzie, Jan Allison, Helen E Thomas

Book Chapter  |  2008  |  Novartis Foundation symposium

CD8+ T cells are the principal cellular mediators of beta cell destruction in the NOD mouse. Molecular mediators include perforin ..

Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets

Sarah L Londrigan, Jamie L Brady, Robyn M Sutherland, Wayne J Hawthorne, Helen E Thomas, Guarang Jhala, Peter J Cowan, Thomas WH Kay, Philip J O'Connell, Andrew M Lew

Journal article  |  2007  |  Xenotransplantation

SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes

Ana Maria Barral, Helen E Thomas, Eleanor M Ling, Rima Darwiche, Evelyn Rodrigo, Urs Christen, Mette Ejrnaes, Tom Wolfe, Thomas W Kay, Matthias G von Herrath

Journal article  |  2006  |  Journal of Autoimmunity

Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid

Eugene Estella, Mark D McKenzie, Tara Catterall, Vivien R Sutton, Phillip I Bird, Joseph A Trapani, Thomas W Kay, Helen E Thomas

Journal article  |  2006  |  Diabetes

IL-1 beta breaks tolerance through expansion of CD25( ) effector T cells

Brendan J O'Sullivan, Helen E Thomas, Saparna Pai, Pere Santamaria, Yoichiro Iwakura, Raymond J Steptoe, Thomas WH Kay, Ranjeny Thomas

Journal article  |  2006  |  Journal of Immunology

Perforin and Fas induced by IFN gamma and TNF alpha mediate beta cell death by OT-I CTL

Mark D McKenzie, Nadine L Dudek, Lina Mariana, Mark MW Chong, Joseph A Trapani, Thomas WH Kay, Helen E Thomas

Journal article  |  2006  |  International Immunology

Perturbations in nuclear factor-kappa B or c-Jun N-terminal kinase pathways in pancreatic beta cells confer susceptibility to cytokine-induced cell death

HE Thomas, E Angstetra, RV Fernandes, L Mariana, W Irawaty, EL Jamieson, NL Dudek, TW Kay

Journal article  |  2006  |  Immunology and Cell Biology

A critical role for granzyme B, in addition to perforin and TNF alpha, in alloreactive CTL-induced mouse pancreatic beta cell death

VR Sutton, E Estella, C Li, M Chen, HE Thomas, TW Kay, JA Trapani

Journal article  |  2006  |  Transplantation