Helen Thomas

E2f8 and Dlg2 genes have independent effects on impaired insulin secretion associated with hyperglycaemia

Chieh-Hsin Yang, Salvatore P Mangiafico, Michaela Waibel, Thomas Loudovaris, Kim Loh, Helen E Thomas, Grant Morahan, Sofianos Andrikopoulos

Journal article  |  2020  |  Diabetologia

AIMS/HYPOTHESIS: Reduced insulin secretion results in hyperglycaemia and diabetes involving a complex aetiology that is yet to be ..

Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans.

Mohammed Bensellam, Yan-Chuan Shi, Jeng Yie Chan, D Ross Laybutt, Heeyoung Chae, Michel Abou-Samra, Evan G Pappas, Helen E Thomas, Patrick Gilon, Jean-Christophe Jonas

Journal article  |  2019  |  Diabetologia

AIMS/HYPOTHESIS: The mechanisms responsible for beta cell compensation in obesity and for beta cell failure in type 2 diabetes are..

IL-21 regulates SOCS1 expression in autoreactive CD8( ) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice

Andrew PR Sutherland, Kate L Graham, Michelle Papadimitriou, Gaurang Jhala, Prerak Trivedi, Tara Catterall, Stacey Fynch, Thomas WH Kay, Helen E Thomas

Journal article  |  2019  |  Scientific Reports

In type 1 diabetes, maturation of activated autoreactive CD8+ T cells to fully armed effector cytotoxic T lymphocytes (CTL) occurs..

Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice

Prerak M Trivedi, Stacey Fynch, Lucy M Kennedy, Jonathan Chee, Balasubramanian Krishnamurthy, Lorraine A O'Reilly, Andreas Strasser, Thomas WH Kay, Helen E Thomas

Journal article  |  2019  |  Cell Death Discovery

CD8+ T cells play a central role in beta-cell destruction in type 1 diabetes. CD8+ T cells use two main effector pathways to kill ..

Phlda3 regulates beta cell survival during stress.

Mohammed Bensellam, Jeng Yie Chan, Kailun Lee, Mugdha V Joglekar, Anandwardhan A Hardikar, Thomas Loudovaris, Helen E Thomas, Jean-Christophe Jonas, D Ross Laybutt

Journal article  |  2019  |  Scientific Reports

The loss of functional beta cell mass characterises all forms of diabetes. Beta cells are highly susceptible to stress, including ..

Replica moulded poly(dimethylsiloxane) microwell arrays induce localized endothelial cell immobilization for coculture with pancreatic islets

Anouck LS Burzava, Aurelien Forget, Frances J Harding, Michaelia P Cockshell, Daniella Penko, Camille Rouzaud, Vincent Ahmadi, Paula F Marina, Darling Rojas-Canales, Claudine S Bonder, P Toby H Coates, Michaela Waibel, Helen E Thomas, Thomas W Kay, Thomas Loudovaris, Anton Blencowe, Nicolas H Voelcker

Journal article  |  2019  |  Biointerphases

Replacing murine insulin 1 with human insulin protects NOD mice from diabetes.

Colleen M Elso, Nicholas A Scott, Lina Mariana, Emma I Masterman, Andrew PR Sutherland, Helen E Thomas, Stuart I Mannering

Journal article  |  2019  |  PLoS One

Type 1, or autoimmune, diabetes is caused by the T-cell mediated destruction of the insulin-producing pancreatic beta cells. Non-o..

IFN gamma-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4( ) T Cell Migration

Nicholas A Scott, Yuxing Zhao, Balasubramanian Krishnamurthy, Stuart I Mannering, Thomas WH Kay, Helen E Thomas

Journal article  |  2018  |  Frontiers in Immunology

Proinsulin C-peptide is an autoantigen in people with type 1 diabetes

Michelle So, Colleen M Elso, Eleonora Tresoldi, Miha Pakusch, Vimukthi Pathiraja, John M Wentworth, Leonard C Harrison, Balasubramanian Krishnamurthy, Helen E Thomas, Christine Rodda, Fergus J Cameron, Jacinta McMahon, Thomas WH Kay, Stuart I Mannering

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Type I Interferon Signaling Is Required for Dacryoadenitis in the Nonobese Diabetic Mouse Model of Sjogren Syndrome

Yury Chaly, Jennifer Y Barr, David A Sullivan, Helen E Thomas, Thomas C Brodnicki, Scott M Lieberman

Journal article  |  2018  |  International Journal of Molecular Sciences