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Prof

Ian Campbell

Honorary
The Sir Peter Maccallum Department Of Oncology
science & technology
life sciences & biomedicine
humans
female
oncology
ovarian neoplasms
genetic predisposition to disease
polymorphism, single nucleotide
breast neoplasms
Ian Campbell's Profile Picture
Prof

Ian Campbell

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Cancer Genetics
Ian Campbell's Profile Picture
Prof

Ian Campbell

 

Projects

Displaying the 45 most recent projects by Ian Campbell.

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Integrative Approaches To Identifying The Causes Of Familial Breast Cancer

2020 - 2023
Active
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Precision Genomic Medicine In Breast Cancer: Synergising Somatic And Germline Mutation Testing

2020 - 2021
Active
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Research Scientist And Grant Writing For Wilson Centre For Lymphoma Genomics

2019 - 2020
Active
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The Kathleen Cuningham Foundation Consortium For Research Into Familial Breast Cancer (Kconfab)

2018 - 2022
Active
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Population Based Genetic Testing For High-Risk Breast And Ovarian Cancer Predisposition Genes

Inherited mutations in BRCA1 and BRCA2 confer a very high risk of breast and ovarian cancer. Importantly, once carriers are identified, effe..

2017 - 2020
Active
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Population Based Genetic Testing For High-Risk Breast And Ovarian Cancer Predisposition Genes

Inherited mutations in BRCA1 and BRCA2 confer a very high risk of breast and ovarian cancer. Importantly, once carriers are identified, effe..

2017 - 2020
Active
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Resolution Of The Missing Heritability Of Breast Cancer

2016 - 2019
Completed
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Improving Early Detection And Management Of Women At Risk Of Developing Interval Breast Cancer

2016 - 2018
Completed
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Improving Outcomes For Women With Epithelial Ovarian Cancer

nan

2016 - 2020
Active
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Improving Outcomes For Women With Epithelial Ovarian Cancer

nan

2016 - 2020
Active
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Improving Outcomes For Women With Epithelial Ovarian Cancer

nan

2016 - 2020
Active
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Lifepool Is A Powerful And Unique Resource That Will Facilitate The Development And Validation Of New Ideas For Treatment And Early Detection Of Breast Cancer

2016 - 2019
Completed
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Improving Population Based Mammographic Screening

2015 - 2018
Completed
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Improving Population Based Mammographic Screening

2015 - 2018
Completed
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Lifepool Is A Powerful And Unique Resource That Will Facilitate The Development And Validation Of New Ideas For Treatment And Early Detection Of Breast Cancer

2015 - 2019
Completed
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Lifepool Is A Powerful And Unique Resource That Will Facilitate The Development And Validation Of New Ideas For Treatment And Early Detection Of Breast Cancer

2015 - 2019
Completed
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The Inherited Cancer Connect (Icon) Partnership

2013 - 2019
Completed
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Identification Of Novel Genes Predisposing To Familial Colorectal Cancer By Full Exome Sequencing

A third of people who develop bowel cancer have a family history of the condition. Currently, we only understand the genes involved in a sma..

2013 - 2013
Completed
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Identification Of Genes In Involved In The Predisposition, Initiation And Progression Of Breast And Ovarian Cancer

Our knowledge of the number and nature of the genes involved in breast and ovarian cancer is limited. To rapidly define the critical breast ..

2013 - 2018
Completed
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Familial Cin Colorectal Cancer

A third of people who develop bowel cancer have a family history of the condition. Currently, we only understand the genes involved in a sma..

2013 - 2014
Completed
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Improving Outcomes For Women Diagnosed With Mucinous Ovarian Cancer

Mucinous ovarian cancer (MOC) is different from other ovarian cancers but few studies have characterized the genetic changes specific to thi..

2013 - 2016
Completed
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Transition Funds For Identification Of Genes Involved In The Predispostion And Progression Of Breast Cancer

2012 - 2013
Completed
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Translation Of Mammographic Density, A Strong And Heritable Risk Factor For Breast Cancer, Into Clinical Practice.

2012 - 2013
Completed
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Identification Of Novel Genes Predisposing To Male Breast Cancer, Their Prevalence And Associated Cancer Risks

Male breast cancer (MBC) is rare and understudied. Using the latest technology, this study will identify new genes which cause familial MBC ..

2012 - 2013
Completed
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Understanding Familial Aspects Of Sarcoma In Adults: The International Sarcoma Kindred Study

Inherited genetic risk is important in cancers that affect the young. The International Sarcoma Kindred Study (ISKS) is the world's first pr..

2011 - 2013
Completed
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Translation Of Mammographic Density, A Strong And Heritable Risk Factor For Breast Cancer, Into Clinical Practice.

2010 - 2012
Completed
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Translation Of Mammographic Density, A Strong And Heritable Risk Factor For Breast Cancer, Into Clinical Practice.

2010 - 2012
Completed
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Translation Of Mammographic Density, A Strong And Heritable Risk Factor For Breast Cancer, Into Clinical Practice.

2010 - 2012
Completed
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Indentification Of Breast Cancer Genes

2010 - 2013
Completed
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Genome-Wide Analysis Of Early Ovarian Neoplasms

Ovarian cancer is the 5th leading cause of cancer death in women. For such a significant disease, remarkably little is know about its origin..

2010 - 2012
Completed
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Dna Analysis Of Ovarian Cancer Genes

In Australia in 2001 there were approximately 1300 new cases of ovarian cancer. Survival of ovarian cancer is very poor and current treatmen..

2010 - 2010
Completed
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Identification Of Genes Involved In The Predispostion And Progression Of Breast Cancer

2009 - 2012
Completed
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Translation Of Mammographic Density, A Strong And Heritable Risk Factor For Breast Cancer, Into Clinical Practice.

2009 - 2012
Completed
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Integration Of Breast Screen With The Epidemiological Molecular And Translational Research Program

2009 - 2016
Completed
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Integration Of Breast Screen With The Epidemiological Molecular And Translational Research Program

2009 - 2016
Completed
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Integration Of Breast Screen With The Epidemiological Molecular And Translational Research Program

2009 - 2017
Completed
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Cancer Associated Fibroblasts

2009 - 2011
Completed
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Genome-Wide Analysis Of Dcis

DCIS is the most common type of noninvasive breast cancer and in some women may progress to malignant disease but little in know about how i..

2008 - 2010
Completed
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Research Fellowship

I am a molecular geneticist with a particular interest in breast and ovarian cancer

2008 - 2012
Completed
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Identification Of Breast And Ovarian Tumour Suppressor Genes On Chromosome 22 By Functional Complementation

Cancer is fundamentally a genetic disease that arises when errors (mutations) accumulate in genes involved in regulating how and when cells ..

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Biomolecular Fingerprints As Early Diagnostic Indicators Of Ovarian Cancer

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Genome-Wide Study Of Loss Of Heterozygosity Using High Density Snp Arrays To Identify Breast Cancer Predisposition Genes

The genes responsible for the majority of breast cancer families remain unknown. The genes BRCA1 and BRCA2 can prevent the development of ca..

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Genome-Wide Snp Analysis Of Fibroblasts Juxtaposed Or Distant From Epithelial Breast And Ovarian Tumours

In the past it was believed that the driving factor in the process of cancer devlopment was the cancer tissue itself. More recently however,..

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Phosphatidylinositol 3-Kinase Mutations Associated With Ovarian, Colon And Breast Tumours

Colorectal and breast cancers are the two most common registrable cancers in Australia and are second only to lung cancer in the total numbe..

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Molecular And Functional Analysis Of The Chromosome 7q31 Tumour Suppressor Gene St7

45

Projects

Project Types

44

Research Grant

1

Research Contracts

Scholarly Works

Displaying the 170 most recent scholarly works by Ian Campbell.

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Germline whole exome sequencing of a family with appendiceal mucinous tumours presenting with pseudomyxoma peritonei

Mei Sim Lung, Catherine A Mitchell, Maria A Doyle, Andrew C Lynch, Kylie L Gorringe, David DL Bowtell, Ian G Campbell, Alison H Trainer

Journal article  |  2020  |  BMC Cancer

BACKGROUND: Familial cases of appendiceal mucinous tumours (AMTs) are extremely rare and the underlying genetic aetiology uncertai..

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Exome sequencing of familial high-grade serous ovarian carcinoma reveals heterogeneity for rare candidate susceptibility genes

Deepak N Subramanian, Magnus Zethoven, Simone McInerny, James A Morgan, Simone M Rowley, Jue Er Amanda Lee, Na Li, Kylie L Gorringe, Paul A James, Ian G Campbell

Journal article  |  2020  |  Nature Communications

High-grade serous ovarian carcinoma (HGSOC) has a significant hereditary component, approximately half of which cannot be explaine..

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ARE VICTORIAN WOMEN INTERESTED IN RISK STRATIFIED BREAST SCREENING?

J Lippey, L Keogh, GB Mann, I Campbell, L Forrest

Conference Proceedings  |  2020  |  BREAST

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The genetic architecture of breast papillary lesions as a predictor of progression to carcinoma

Tanjina Kader, Kenneth Elder, Magnus Zethoven, Timothy Semple, Prue Hill, David L Goode, Niko Thio, Dane Cheasley, Simone M Rowley, David J Byrne, Jia-Min Pang, Islam M Miligy, Andrew R Green, Emad A Rakha, Stephen B Fox, G Bruce Mann, Ian G Campbell, Kylie L Gorringe

Journal article  |  2020  |  npj Breast Cancer

Intraductal papillomas (IDP) are challenging breast findings because of their variable risk of progression to malignancy. The mole..

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Transcriptome-wide association study of breast cancer risk by estrogen-receptor status

Helian Feng, Alexander Gusev, Bogdan Pasaniuc, Lang Wu, Jirong Long, Zomoroda Abu-full, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Antonis C Antoniou, Adalgeir Arason, Volker Arndt, Kristan J Aronson, Banu K Arun, Ella Asseryanis, Paul L Auer, Jacopo Azzollini, Judith Balmana, Rosa B Barkardottir, Daniel R Barnes, et al.

Journal article  |  2020  |  Genetic Epidemiology

Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expressio..

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Therapeutic options for mucinous ovarian carcinoma

Kylie L Gorringe, Dane Cheasley, Matthew J Wakefield, Georgina L Ryland, Prue E Allan, Kathryn Alsop, Kaushalya C Amarasinghe, Sumitra Ananda, David DL Bowtell, Michael Christie, Yoke-Eng Chiew, Michael Churchman, Anna DeFazio, Sian Fereday, C Blake Gilks, Charlie Gourley, Alison M Hadley, Joy Hendley, Sally M Hunter, Scott H Kaufmann, et al.

Journal article  |  2020  |  Gynecologic Oncology

OBJECTIVE: Mucinous ovarian carcinoma (MOC) is an uncommon ovarian cancer histotype that responds poorly to conventional chemother..

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Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness

Vivek L Patel, Evan L Busch, Tara M Friebel, Angel Cronin, Goska Leslie, Lesley McGuffog, Julian Adlard, Simona Agata, Bjarni A Agnarsson, Munaza Ahmed, Kristiina Aittomaki, Elisa Alducci, Irene L Andrulis, Adalgeir Arason, Norbert Arnold, Grazia Artioli, Brita Arver, Bernd Auber, Jacopo Azzollini, Judith Balmana, et al.

Journal article  |  2020  |  Cancer Research

Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer...

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Evaluation of genomic changes in ductal carcinoma in situ as potential biomarkers of recurrence risk

Dorothea Lesche, Hugo Saunders, Sakshi Mahale, Magnus Zenthoven, Siobhan Huges, Tanjina Kader, Niko Thio, Islam M Miligy, Jia-Min Pang, Andrew R Green, Emad A Rakha, Ian G Campbell, Stephen B Fox, Kylie Gorringe

Conference Proceedings  |  2020  |  Poster Session Abstracts

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Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R Barnes, Jamie Allen, Siddhartha Kar, Karen A Pooley, Joe Dennis, Kyriaki Michailidou, Constance Turman, Penny Soucy, Audrey Lemacon, Michael Lush, Jonathan P Tyrer, Maya Ghoussaini, Mahdi Moradi Marjaneh, Xia Jiang, Simona Agata, Kristiina Aittomaki, M Rosario Alonso, et al.

Journal article  |  2020  |  Nature Genetics

Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underl..

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Combined Tumor Sequencing and Case-Control Analyses of RAD51C in Breast Cancer

Na Li, Simone McInerny, Magnus Zethoven, Dane Cheasley, Belle WX Lim, Simone M Rowley, Lisa Devereux, Norah Grewal, Somayeh Ahmadloo, David Byrne, Jue Er Amanda Lee, Jason Li, Stephen B Fox, Thomas John, Yoland Antill, Kylie L Gorringe, Paul A James, Ian G Campbell

Journal article  |  2019  |  JNCI: Journal of the National Cancer Institute

BACKGROUND: Loss-of-function variants in RAD51C are associated with familial ovarian cancer, but its role in hereditary breast can..

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A combination of the immunohistochemical markers CK7 and SATB2 is highly sensitive and specific for distinguishing primary ovarian mucinous tumors from colorectal and appendiceal metastases

Nicola S Meagher, Linyuan Wang, Peter F Rambau, Maria P Intermaggio, David G Huntsman, Lynne R Wilkens, Mona A El-Bahrawy, Roberta B Ness, Kunle Odunsi, Helen Steed, Esther Herpel, Michael S Anglesio, Bonnie Zhang, Neil Lambie, Anthony J Swerdlow, Jan Lubinski, Robert A Vierkant, Ellen L Goode, Usha Menon, Aleksandra Toloczko-Grabarek, et al.

Journal article  |  2019  |  Modern Pathology

Primary ovarian mucinous tumors can be difficult to distinguish from metastatic gastrointestinal neoplasms by histology alone. The..

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Development and validation of a targeted gene sequencing panel for application to disparate cancers

Mark J McCabe, Marie-Emilie A Gauthier, Chia-Ling Chan, Tanya J Thompson, Sunita MC De Sousa, Clare Puttick, John P Grady, Velimir Gayevskiy, Jiang Tao, Kevin Ying, Arcadi Cipponi, Niantao Deng, Alex Swarbrick, Melissa L Thomas, undefined kConFab, Reginald V Lord, Amber L Johns, Maija Kohonen-Corish, Sandra A O'Toole, Jonathan Clark, et al.

Journal article  |  2019  |  Scientific Reports

Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology ..

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The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca, Sandra Viz Lasheras, Roser Pujol, Johanna Kiiski, Taru A Muranen, Daniel R Barnes, Joe Dennis, Kyriaki Michailidou, Manjeet K Bolla, Goska Leslie, Cora M Aalfs, Muriel A Adank, Julian Adlard, Simona Agata, Karen Cadoo, Bjarni A Agnarsson, Thomas Ahearn, et al.

Journal article  |  2019  |  npj Breast Cancer

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1..

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Integration of tumour sequencing and case-control analyses is a powerful tool for identification of cancer predisposition genes

I Campbell, N Li, B Lim, S McInerny, M Zethoven, D Cheasley, S Rowley, L Devereux, A Lee, N Grewal, P James

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF HUMAN GENETICS

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The molecular origin and taxonomy of mucinous ovarian carcinoma

Dane Cheasley, Matthew J Wakefield, Georgina L Ryland, Prue E Allan, Kathryn Alsop, Kaushalya C Amarasinghe, Sumitra Ananda, Michael S Anglesio, George Au-Yeung, Maret Bohm, David Dl Bowtell, Alison Brand, Georgia Chenevix-Trench, Michael Christie, Yoke-Eng Chiew, Michael Churchman, Anna DeFazio, Renee Demeo, Rhiannon Dudley, Nicole Fairweather, et al.

Journal article  |  2019  |  Nature Communications

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MOLECULAR DETERMINANTS OF CDK4 INHIBITOR ACTIVITY IN LOW-GRADE SEROUS OVARIAN CANCER

M Llaurado Fernandez, J Hoenisch, H Kim, A Dawson, N Lam, D Cheasley, K Gorrienge, N Abhimanyu, I Campbell, D Huntsman, G DiMattia, M Kobel, M Carey

Conference Proceedings  |  2019  |  E-Poster viewings

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MUCINOUS OVARIAN CARCINOMA: THERAPEUTIC OPTIONS OLD AND NEW

K Gorringe, D Cheasley, M Wakefield, I Campbell, Y Antill, C Scott

Conference Proceedings  |  2019  |  Plenary sessions

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Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers

Frank Qian, Matti A Rookus, Goska Leslie, Harvey A Risch, Mark H Greene, Cora M Aalfs, Muriel A Adank, Julian Adlard, Bjarni A Agnarsson, Munaza Ahmed, Kristiina Aittomaki, Irene L Andrulis, Norbert Arnold, Banu K Arun, Margreet GEM Ausems, Jacopo Azzollini, Daniel Barrowdale, Julian Barwell, Javier Benitez, Katarzyna Bialkowska, et al.

Journal article  |  2019  |  British Journal of Cancer

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Atypical ductal hyperplasia is a multipotent precursor of breast carcinoma

Tanjina Kader, Prue Hill, Magnus Zethoven, David L Goode, Kenneth Elder, Niko Thio, Maria Doyle, Timothy Semple, Wajiha Sufyan, David J Byrne, Jia-Min B Pang, Anand Murugasu, Islam M Miligy, Andrew R Green, Emad A Rakha, Stephen B Fox, G Bruce Mann, Ian G Campbell, Kylie L Gorringe

Journal article  |  2019  |  The Journal of Pathology

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Topical application of human-derived Ig isotypes for the control of acute respiratory infection evaluated in a human CD89-expressing mouse model

Sandra Koernig, Ian K Campbell, Charley Mackenzie-Kludas, Alexander Schaub, Marius Loetscher, Wy Ching Ng, Roland Zehnder, Pawel Pelczar, Ildem Sanli, Monther Alhamdoosh, Milica Ng, Lorena E Brown, Fabian Kasermann, Cedric Vonarburg, Adrian W Zuercher

Journal article  |  2019  |  Mucosal Immunology

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"A Natural Progression": Australian Women's Attitudes About an Individualized Breast Screening Model

Jocelyn Lippey, Louise A Keogh, G Bruce Mann, Ian G Campbell, Laura E Forrest

Journal article  |  2019  |  Cancer Prevention Research

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Molecular comparison of interval and screen-detected breast cancers

Dane Cheasley, Na Li, Simone M Rowley, Kenneth Elder, G Bruce Mann, Sherene Loi, Peter Savas, David L Goode, Tanjina Kader, Magnus Zethoven, Tim Semple, Stephen B Fox, Jia-Min Pang, David Byrne, Lisa Devereux, Carolyn Nickson, Pietro Procopio, Grant Lee, Siobhan Hughes, Hugo Saunders, et al.

Journal article  |  2019  |  The Journal of Pathology

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Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women

Delores J Grant, Ani Manichaikul, Anthony J Alberg, Elisa Bandera, Jill Barnholtz-Sloan, Melissa Bondy, Michele L Cote, Ellen Funkhouser, Patricia G Moorman, Lauren C Peres, Edward S Peters, Ann G Schwartz, Paul D Terry, Xin-Qun Wang, Temitope O Keku, Cathrine Hoyo, Andrew Berchuck, Dale P Sandler, Jack A Taylor, Katie M O'Brien, et al.

Journal article  |  2019  |  Cancer Medicine

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Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Manuel A Ferreira, Eric R Gamazon, Fares Al-Ejeh, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Adalgeir Arason, Volker Arndt, Kristan J Aronson, Banu K Arun, Ella Asseryanis, Jacopo Azzollini, Judith Balmana, Daniel R Barnes, Daniel Barrowdale, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Katarzyna Bialkowska, et al.

Journal article  |  2019  |  Nature Communications

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Population-based genetic testing of asymptomatic women for breast and ovarian cancer susceptibility

Simone M Rowley, Lyon Mascarenhas, Lisa Devereux, Na Li, Kaushalya C Amarasinghe, Magnus Zethoven, Jue Er Amanda Lee, Alexandra Lewis, James A Morgan, Sharpe Limb, Mary-Anne Young, Paul A James, Alison H Trainer, Ian G Campbell

Journal article  |  2019  |  Genetics in Medicine

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Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study

Frank Qian, Shengfeng Wang, Jonathan Mitchell, Lesley McGuffog, Daniel Barrowdale, Goska Leslie, Jan C Oosterwijk, Wendy K Chung, D Gareth Evans, Christoph Engel, Karin Kast, Cora M Aalfs, Muriel A Adank, Julian Adlard, Bjarni A Agnarsson, Kristiina Aittomaki, Elisa Alducci, Irene L Andrulis, Banu K Arun, Margreet GEM Ausems, et al.

Journal article  |  2019  |  JNCI: Journal of the National Cancer Institute

BACKGROUND: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether hei..

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Mutational Signature Analysis Reveals NTHL1 Deficiency to Cause a Multi-tumor Phenotype

Judith E Grolleman, Richarda M de Voer, Fadwa A Elsayed, Maartje Nielsen, Robbert DA Weren, Claire Palles, Marjolijn JL Ligtenberg, Janet R Vos, Sanne W ten Broeke, Noel FCC de Miranda, Renske A Kuiper, Eveline J Kamping, Erik AM Jansen, M Elisa Vink-Borger, Isabell Popp, Alois Lang, Isabel Spier, Robert Hueneburg, Paul A James, Na Li, et al.

Journal article  |  2019  |  Cancer Cell

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Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk

Yaohua Yang, Lang Wu, Xiang Shu, Yingchang Lu, Xiao-Ou Shu, Qiuyin Cai, Alicia Beeghly-Fadiel, Bingshan Li, Fei Ye, Andrew Berchuck, Hoda Anton-Culver, Susana Banerjee, Javier Benitez, Line Bjorge, James D Brenton, Ralf Butzow, Ian G Campbell, Jenny Chang-Claude, Kexin Chen, Linda S Cook, et al.

Journal article  |  2019  |  Cancer Research

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Shared heritability and functional enrichment across six solid cancers

Xia Jiang, Hilary K Finucane, Fredrick R Schumacher, Stephanie L Schmit, Jonathan P Tyrer, Younghun Han, Kyriaki Michailidou, Corina Lesseur, Karoline B Kuchenbaecker, Joe Dennis, David V Conti, Graham Casey, Mia M Gaudet, Jeroen R Huyghe, Demetrius Albanes, Melinda C Aldrich, Angeline S Andrew, Irene L Andrulis, Hoda Anton-Culver, Antonis C Antoniou, et al.

Journal article  |  2019  |  Nature Communications

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Mutational Landscape of Ovarian Adult Granulosa Cell Tumors from Whole Exome and Targeted TERT Promoter Sequencing

Maria Alexiadis, Simone M Rowley, Simon Chu, Dilys TH Leung, Colin JR Stewart, Kaushalya C Amarasinghe, Ian G Campbell, Peter J Fuller

Journal article  |  2019  |  Molecular Cancer Research

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When Is "Type I" Ovarian Cancer Not "Type I"? Indications of an Out-Dated Dichotomy

Carolina Salazar, Ian G Campbell, Kylie L Gorringe

Journal article  |  2018  |  Frontiers in Oncology

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Prospective validation of the NCI Breast Cancer Risk Assessment Tool (Gail Model) on 40,000 Australian women

Carolyn Nickson, Pietro Procopio, Louiza S Velentzis, Sarah Carr, Lisa Devereux, Gregory Bruce Mann, Paul James, Grant Lee, Cameron Wellard, Ian Campbell

Journal article  |  2018  |  Breast Cancer Research

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Mutations in RECQL are not associated with breast cancer risk in an Australian population

Na Li, Simone M Rowley, David L Goode, Kaushalya C Amarasinghe, Simone McInerny, Lisa Devereux, Michelle W Wong-Brown, Richard Lupat, Jue Er Amanda Lee, Siobhan Hughes, Ella R Thompson, Magnus Zethoven, Jason Li, Alison H Trainer, Kylie L Gorringe, Rodney J Scott, Paul A James, Ian G Campbell

Journal article  |  2018  |  Nature Genetics

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Population-based testing for hereditary breast and ovarian cancer predisposing mutations in the Australian community

IG Campbell, S Rowley, AH Trainer, M Young, undefined Lifepool, L Devereux, PA James

Conference Proceedings  |  2018  |  EUROPEAN JOURNAL OF HUMAN GENETICS

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The contribution of rare variants, polygenic risk, and novel candidate genes to the hereditary risk of breast cancer in a large cohort of Breast Cancer families

PA James, N Li, S Rowley, D Goode, L Devereux, S McInerny, N Grewal, A Trainer, R Scott, I Campbell

Conference Proceedings  |  2018  |  EUROPEAN JOURNAL OF HUMAN GENETICS

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Gene Discovery through Germline Whole Exome Sequencing in Patients with Endometriosis-Associated Ovarian Cancer

Eryn Dow, Ian Campbell, Paul James, Yoland Antill, Deepak Subramanian

Conference Proceedings  |  2018  |  INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

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Mutational Landscape of Adult Granulosa Cell Tumors of the Ovary from Whole Exome Sequencing

Simon Chu, Maria Alexiadis, Dilys Leung, Simone Rowley, Ian Campbell, Peter Fuller

Conference Proceedings  |  2018  |  INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

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Therapeutic opportunities in mucinous ovarian carcinoma

Kylie Gorringe, Ian Campbell, Clare Scott, Prue Allan, Dane Cheasley, Matthew Wakefield, Yoland Antill

Conference Proceedings  |  2018  |  INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

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A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk

Yingchang Lu, Alicia Beeghly-Fadiel, Lang Wu, Xingyi Guo, Bingshan Li, Joellen M Schildkraut, Hae Kyung Im, Yian A Chen, Jennifer B Permuth, Brett M Reid, Jamie K Teer, Kirsten B Moysich, Irene L Andrulis, Hoda Anton-Culver, Banu K Arun, Elisa V Bandera, Rosa B Barkardottir, Daniel R Barnes, Javier Benitez, Line Bjorge, et al.

Journal article  |  2018  |  Cancer Research

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rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology

Linda E Kelemen, Madalene Earp, Brooke L Fridley, Georgia Chenevix-Trench, Peter A Fasching, Matthias W Beckmann, Arif B Ekici, Alexander Hein, Diether Lambrechts, Sandrina Lambrechts, Els Van Nieuwenhuysen, Ignace Vergote, Mary Anne Rossing, Jennifer A Doherty, Jenny Chang-Claude, Sabine Behrens, Kirsten B Moysich, Rikki Cannioto, Shashikant Lele, Kunle Odunsi, et al.

Journal article  |  2018  |  International Journal of Molecular Sciences

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Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility

Madalene Earp, Jonathan P Tyrer, Stacey J Winham, Hui-Yi Lin, Ganna Chornokur, Joe Dennis, Katja KH Aben, Hoda Anton-Culver, Natalia Antonenkova, Elisa V Bandera, Yukie T Bean, Matthias W Beckmann, Line Bjorge, Natalia Bogdanova, Louise A Brinton, Angela Brooks-Wilson, Fiona Bruinsma, Clareann H Bunker, Ralf Butzow, Ian G Campbell, et al.

Journal article  |  2018  |  PLOS ONE

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Tumor-infiltrating CD8-positive T-lymphocytes in tubo-ovarian high-grade serous cancer are associated with multiple germline variants in 22q12.1 in a genome-wide association analysis

Yanina Natanzon, Martin Kobel, Stacey J Winham, Sebastian M Armasu, Bryan M McCauley, Robert A Vierkant, Julie M Cunningham, David Bowtell, Ian G Campbell, Jenny Chang-Claude, Anna deFazio, Peter A Fasching, Mark T Goodman, Beth Y Karlan, Francesmary Modugno, Kirsten B Moysich, Roberta B Ness, Weiva Sieh, Paul D Pharoah, Susan J Ramus, et al.

Conference Proceedings  |  2018  |  Epidemiology

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The utility of genomics and functional imaging to predict Sunitinib PK and PD: The Predict SU study.

Michael Michael, David William Pook, Vinod Ganju, Emma Link, Guy C Toner, Rodney J Hicks, Anetta Matera, Mick Thompson, Carleen Cullinane, Ian Campbell, Matthew Burge, Christos Stelios Karapetis

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

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Atypical ductal hyperplasia: update on diagnosis, management, and molecular landscape

Tanjina Kader, Prue Hill, Emad A Rakha, Ian G Campbell, Kylie L Gorringe

Journal article  |  2018  |  Breast Cancer Research

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Molecular analysis of PALB2-associated breast cancers

Jue Er Amanda Lee, Na Li, Simone M Rowley, Dane Cheasley, Magnus Zethoven, Simone McInerny, Kylie L Gorringe, Paul A James, Ian G Campbell

Journal article  |  2018  |  The Journal of Pathology

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Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations

Timothy R Rebbeck, Tara M Friebel, Eitan Friedman, Ute Hamann, Dezheng Huo, Ava Kwong, Edith Olah, Olufunmilayo I Olopade, Angela R Solano, Soo-Hwang Teo, Mads Thomassen, Jeffrey N Weitzel, TL Chan, Fergus J Couch, David E Goldgar, Torben A Kruse, Edenir Inez Palmero, Sue Kyung Park, Diana Torres, Elizabeth J van Rensburg, et al.

Journal article  |  2018  |  Human Mutation

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Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study

Suzanne C Dixon-Suen, Christina M Nagle, Aaron P Thrift, Paul DP Pharoah, Ailith Ewing, Celeste Leigh Pearce, Wei Zheng, Georgia Chenevix-Trench, Peter A Fasching, Matthias W Beckmann, Diether Lambrechts, Ignace Vergote, Sandrina Lambrechts, Els Van Nieuwenhuysen, Mary Anne Rossing, Jennifer A Doherty, Kristine G Wicklund, Jenny Chang-Claude, Audrey Y Jung, Kirsten B Moysich, et al.

Journal article  |  2018  |  British Journal of Cancer

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MyD88 and TLR4 Expression in Epithelial Ovarian Cancer

Matthew S Block, Robert A Vierkant, Peter F Rambau, Stacey J Winham, Philipp Wagner, Nadia Traficante, Aleksandra Toloczko, Daniel G Tiezzi, Florin Andrei Taran, Peter Sinn, Weiva Sieh, Raghwa Sharma, Joseph H Rothstein, Teresa Ramon y Cajal, Luis Paz-Ares, Oleg Oszurek, Sandra Orsulic, Roberta B Ness, Gregg Nelson, Francesmary Modugno, et al.

Journal article  |  2018  |  Mayo Clinic Proceedings

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Genomic analysis of cancers arising in breasts with different mammographic density

Kylie L Gorringe, Siobhan Hughes, Carolyn Nickson, Lisa Devereux, Vicki Pridmore, Simone M Rowley, David J Byrne, Dane Cheasley, Anne M Kavanagh, G Bruce Mann, Stephen B Fox, Ian G Campbell

Conference Proceedings  |  2018  |  CANCER RESEARCH

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Evaluating the breast cancer predisposition role of rare variants in genes associated with low-penetrance breast cancer risk SNPs

Na Li, Simone M Rowley, Ella R Thompson, Simone McInerny, Lisa Devereux, Kaushalya C Amarasinghe, Magnus Zethoven, Richard Lupat, David Goode, Jason Li, Alison H Trainer, Kylie L Gorringe, Paul A James, Ian G Campbell

Journal article  |  2018  |  Breast Cancer Research

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Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Roger L Milne, Karoline B Kuchenbaecker, Kyriaki Michailidou, Jonathan Beesley, Siddhartha Kar, Sara Lindstrom, Shirley Hui, Audrey Lemacon, Penny Soucy, Joe Dennis, Xia Jiang, Asha Rostamianfar, Hilary Finucane, Manjeet K Bolla, Lesley McGuffog, Qin Wang, Cora M Aalfs, Marcia Adams, Julian Adlard, Simona Agata, et al.

Journal article  |  2017  |  Nature Genetics

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Dose-Response Association of CD8( ) Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer

Ellen L Goode, Matthew S Block, Kimberly R Kalli, Robert A Vierkant, Wenqian Chen, Zachary C Fogarty, Aleksandra Gentry-Maharaj, Aleksandra Toloczko, Alexander Hein, Aliecia L Bouligny, Allan Jensen, Ana Osorio, Andreas D Hartkopf, Andy Ryan, Anita Chudecka-Glaz, Anthony M Magliocco, Arndt Hartmann, Audrey Y Jung, Bo Gao, Brenda Y Hernandez, et al.

Journal article  |  2017  |  JAMA Oncology

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Relationship of the Breast Ductal Carcinoma In Situ Immune Microenvironment with Clinicopathological and Genetic Features

Shona Hendry, Jia-Min B Pang, David J Byrne, Sunil R Lakhani, Margaret C Cummings, Ian G Campbell, G Bruce Mann, Kylie L Gorringe, Stephen B Fox

Journal article  |  2017  |  Clinical Cancer Research

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Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores

Julie Lecarpentier, Valentina Silvestri, Karoline B Kuchenbaecker, Daniel Barrowdale, Joe Dennis, Lesley McGuffog, Penny Soucy, Goska Leslie, Piera Rizzolo, Anna Sara Navazio, Virginia Valentini, Veronica Zelli, Andrew Lee, Ali Amin Al Olama, Jonathan P Tyrer, Melissa Southey, Esther M John, Thomas A Conner, David E Goldgar, Saundra S Buys, et al.

Journal article  |  2017  |  Journal of Clinical Oncology

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Traceback: A Proposed Framework to Increase Identification and Genetic Counseling of BRCA1 and BRCA2 Mutation Carriers Through Family-Based Outreach

Goli Samimi, Marcus Q Bernardini, Lawrence C Brody, Charlisse F Caga-anan, Ian G Campbell, Georgia Chenevix-Trench, Fergus J Couch, Michael Dean, Joanne A de Hullu, Susan M Domchek, Ronny Drapkin, Heather Spencer Feigelson, Michael Friedlander, Mia M Gaudet, Marline G Harmsen, Karen Hurley, Paul A James, Janice S Kwon, Felicitas Lacbawan, Stephanie Lheureux, et al.

Journal article  |  2017  |  Journal of Clinical Oncology

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Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer

Jia-Min B Pang, Peter Savas, Andrew P Fellowes, Gisela Mir Arnau, Tanjina Kader, Ravikiran Vedururu, Chelsee Hewitt, Elena A Takano, David J Byrne, David YH hoong, Ewan KA Millar, C Soon Lee, Sandra A O'Toole, Sunil R Lakhani, Margaret C Cummings, G Bruce Mann, Ian G Campbell, Alexander Dobrovic, Sherene Loi, Kylie L Gorringe, et al.

Journal article  |  2017  |  Modern Pathology

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The utility of genomics and functional imaging to predict irinotecan pharmacokinetics and pharmacodynannics: The PREDICT IR study.

Michael Michael, Winston Liauw, Sue-Anne McLachlan, Emma Link, Anetta Matera, Mick Thompson, Michael Jefford, Rodney J Hicks, Carleen Cullinane, Ian Campbell, Philip James Beale, Christos Stelios Karapetis, Timothy Price, Matthew E Burge

Conference Proceedings  |  2017  |  Journal of Clinical Oncology

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Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Catherine M Phelan, Karoline B Kuchenbaecker, Jonathan P Tyrer, Siddhartha P Kar, Kate Lawrenson, Stacey J Winham, Joe Dennis, Ailith Pirie, Marjorie J Riggan, Ganna Chornokur, Madalene A Earp, Paulo C Lyra, Janet M Lee, Simon Coetzee, Jonathan Beesley, Lesley McGuffog, Penny Soucy, Ed Dicks, Andrew Lee, Daniel Barrowdale, et al.

Journal article  |  2017  |  Nature Genetics

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No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival

Lara E Sucheston-Campbell, Rikki Cannioto, Alyssa I Clay, John Lewis Etter, Kevin H Eng, Song Liu, Sebastiano Battaglia, Qiang Hu, J Brian Szender, Albina Minlikeeva, Janine M Joseph, Paul Mayor, Scott I Abrams, Brahm H Segal, Paul K Wallace, Kah Teong Soh, Emese Zsiros, Hoda Anton-Culver, Elisa V Bandera, Matthias W Beckmann, et al.

Journal article  |  2017  |  Cancer Epidemiology Biomarkers & Prevention

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Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci

Siddhartha P Kar, Emily Adler, Jonathan Tyrer, Dennis Hazelett, Hoda Anton-Culver, Elisa V Bandera, Matthias W Beckmann, Andrew Berchuck, Natalia Bogdanova, Louise Brinton, Ralf Butzow, Ian Campbell, Karen Carty, Jenny Chang-Claude, Linda S Cook, Daniel W Cramer, Julie M Cunningham, Agnieszka Dansonka-Mieszkowska, Jennifer Anne Doherty, Thilo Doerk, et al.

Journal article  |  2017  |  British Journal of Cancer

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Compromized DNA repair as a basis for identification of cancer radiotherapy patients with extreme radiosensitivity

Pavel Lobachevsky, Trevor Leong, Patricia Daly, Jai Smith, Nickala Best, Jonathan Tomaszewski, Ella R Thompson, Na Li, Ian G Campbell, Roger F Martin, Olga A Martin

Journal article  |  2016  |  Cancer Letters

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PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS

Melissa C Southey, David E Goldgar, Robert Winqvist, Katri Pylkas, Fergus Couch, Marc Tischkowitz, William D Foulkes, Joe Dennis, Kyriaki Michailidou, Elizabeth J van Rensburg, Tuomas Heikkinen, Heli Nevanlinna, John L Hopper, Thilo Doerk, Kathleen BM Claes, Jorge Reis-Filho, Zhi Ling Teo, Paolo Radice, Irene Catucci, Paolo Peterlongo, et al.

Journal article  |  2016  |  Journal of Medical Genetics

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Copy number analysis by low coverage whole genome sequencing using ultra low-input DNA from formalin-fixed paraffin embedded tumor tissue

Tanjina Kader, David L Goode, Stephen Q Wong, Jacquie Connaughton, Simone M Rowley, Lisa Devereux, David Byrne, Stephen B Fox, Gisela Mir Arnau, Richard W Tothill, Ian G Campbell, Kylie L Gorringe

Journal article  |  2016  |  Genome Medicine

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Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration

Jennifer B Permuth, Brett Reid, Madalene Earp, Y Ann Chen, Alvaro NA Monteiro, Zhihua Chen, Georgia Chenevix-Trench, Peter A Fasching, Matthias W Beckmann, Diether Lambrechts, Adriaan Vanderstichele, Els Van Niewenhuyse, Ignace Vergote, Mary Anne Rossing, Jennifer Anne Doherty, Jenny Chang-Claude, Kirsten Moysich, Kunle Odunsi, Marc T Goodman, Yurii B Shvetsov, et al.

Journal article  |  2016  |  Oncotarget

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Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer

Shalaka S Hampras, Lara E Sucheston-Campbell, Rikki Cannioto, Jenny Chang-Claude, Francesmary Modugno, Thilo Doerk, Peter Hillemanns, Leah Preus, Keith L Knutson, Paul K Wallace, Chi-Chen Hong, Grace Friel, Warren Davis, Mary Nesline, Celeste L Pearce, Linda E Kelemen, Marc T Goodman, Elisa V Bandera, Kathryn L Terry, Nils Schoof, et al.

Journal article  |  2016  |  Oncotarget

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Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study

Jue-Sheng Ong, Gabriel Cuellar-Partida, Yi Lu, Peter A Fasching, Alexander Hein, Stefanie Burghaus, Matthias W Beckmann, Diether Lambrechts, Els Van Nieuwenhuysen, Ignace Vergote, Adriaan Vanderstichele, Jennifer Anne Doherty, Mary Anne Rossing, Jenny Chang-Claude, Ursula Eilber, Anja Rudolph, Shan Wang-Gohrke, Marc T Goodman, Natalia Bogdanova, Thilo Dork, et al.

Journal article  |  2016  |  International Journal of Epidemiology

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Reevaluation of RINT1 as a breast cancer predisposition gene

Na Li, Ella R Thompson, Simone M Rowley, Simone McInerny, Lisa Devereux, David Goode, Michelle W Wong-Brown, Rodney J Scott, Alison H Trainer, Kylie L Gorringe, Paul A James, Ian G Campbell

Journal article  |  2016  |  Breast Cancer Research and Treatment

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Monogenic and polygenic determinants of sarcoma risk: an international genetic study

Mandy L Ballinger, David L Goode, Isabelle Ray-Coquard, Paul A James, Gillian Mitchell, Eveline Niedermayr, Ajay Puri, Joshua D Schiffman, Gillian S Dite, Arcadi Cipponi, Robert G Maki, Andrew S Brohl, Ola Myklebost, Eva W Stratford, Susanne Lorenz, Sung-Min Ahn, Jin-Hee Ahn, Jeong Eun Kim, Sue Shanley, Victoria Beshay, et al.

Journal article  |  2016  |  The Lancet Oncology

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Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Siddhartha P Kar, Jonathan Beesley, Ali Amin Al Olama, Kyriaki Michailidou, Jonathan Tyrer, Zsofi A Kote-Jarai, Kate Lawrenson, Sara Lindstrom, Susan J Ramus, Deborah J Thompson, Adam S Kibel, Agnieszka Dansonka-Mieszkowska, Agnieszka Michael, Aida K Dieffenbach, Aleksandra Gentry-Maharaj, Alice S Whittemore, Alicja Wolk, Alvaro Monteiro, Ana Peixoto, Andrzej Kierzek, et al.

Journal article  |  2016  |  Cancer Discovery

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Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

Kate Lawrenson, Siddhartha Kar, Karen McCue, Karoline Kuchenbaeker, Kyriaki Michailidou, Jonathan Tyrer, Jonathan Beesley, Susan J Ramus, Qiyuan Li, Melissa K Delgado, Janet M Lee, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Banu K Arun, Brita Arver, Elisa V Bandera, Monica Barile, Rosa B Barkardottir, et al.

Journal article  |  2016  |  Nature Communications

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Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Elena Vigorito, Karoline B Kuchenbaecker, Jonathan Beesley, Julian Adlard, Bjarni A Agnarsson, Irene L Andrulis, Banu K Arun, Laure Barjhoux, Muriel Belotti, Javier Benitez, Andreas Berger, Anders Bojesen, Bernardo Bonanni, Carole Brewer, Trinidad Caldes, Maria A Caligo, Ian Campbell, Salina B Chan, Kathleen BM Claes, David E Cohn, et al.

Journal article  |  2016  |  PLOS ONE

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Assessing the genetic architecture of epithelial ovarian cancer histological subtypes

Gabriel Cuellar-Partida, Yi Lu, Suzanne C Dixon, Peter A Fasching, Alexander Hein, Stefanie Burghaus, Matthias W Beckmann, Diether Lambrechts, Els Van Nieuwenhuysen, Ignace Vergote, Adriaan Vanderstichele, Jennifer Anne Doherty, Mary Anne Rossing, Jenny Chang-Claude, Anja Rudolph, Shan Wang-Gohrke, Marc T Goodman, Natalia Bogdanova, Thilo Doerk, Matthias Duerst, et al.

Journal article  |  2016  |  Human Genetics

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Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus

Chenjie Zeng, Xingyi Guo, Jirong Long, Karoline B Kuchenbaecker, Arnaud Droit, Kyriaki Michailidou, Maya Ghoussaini, Siddhartha Kar, Adam Freeman, John L Hopper, Roger L Milne, Manjeet K Bolla, Qin Wang, Joe Dennis, Simona Agata, Shahana Ahmed, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, et al.

Journal article  |  2016  |  Breast Cancer Research

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Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study

Suzanne C Dixon, Christina M Nagle, Aaron P Thrift, Paul DP Pharoah, Celeste Leigh Pearce, Wei Zheng, Jodie N Painter, Georgia Chenevix-Trench, Peter A Fasching, Matthias W Beckmann, Diether Lambrechts, Ignace Vergote, Sandrina Lambrechts, Els Van Nieuwenhuysen, Mary Anne Rossing, Jennifer A Doherty, Kristine G Wicklund, Jenny Chang-Claude, Anja Rudolph, Kirsten B Moysich, et al.

Journal article  |  2016  |  International Journal of Epidemiology

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No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing

Douglas F Easton, Fabienne Lesueur, Brennan Decker, Kyriaki Michailidou, Jun Li, Jamie Allen, Craig Luccarini, Karen A Pooley, Mitul Shah, Manjeet K Bolla, Qin Wang, Joe Dennis, Jamil Ahmad, Ella R Thompson, Francesca Damiola, Maroulio Pertesi, Catherine Voegele, Noura Mebirouk, Nivonirina Robinot, Geoffroy Durand, et al.

Journal article  |  2016  |  Journal of Medical Genetics

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No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

Antoinette Hollestelle, Frederieke H van der Baan, Andrew Berchuck, Sharon E Johnatty, Katja K Aben, Bjarni A Agnarsson, Kristiina Aittomaki, Elisa Alducci, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Antonis C Antoniou, Carmel Apicella, Volker Arndt, Norbert Arnold, Banu K Arun, Brita Arver, Alan Ashworth, Laura Baglietto, Rosemary Balleine, et al.

Journal article  |  2016  |  Gynecologic Oncology

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Panel Testing for Familial Breast Cancer: Calibrating the Tension Between Research and Clinical Care

Ella R Thompson, Simone M Rowley, Na Li, Simone McInerny, Lisa Devereux, Michelle W Wong-Brown, Alison H Trainer, Gillian Mitchell, Rodney J Scott, Paul A James, Ian G Campbell

Journal article  |  2016  |  Journal of Clinical Oncology

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Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer

Sally M Hunter, Simone M Rowley, David Clouston, Jason Li, Richard Lupat, Nishanth Krishnananthan, Gail Risbridger, Renea Taylor, Damien Bolton, Ian G Campbell, Heather Thorne

Journal article  |  2016  |  Urol Oncol

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Genetic testing in a cohort of young patients with HER2-amplified breast cancer

DM Eccles, N Li, R Handwerker, T Maishman, ER Copson, LT Durcan, SM Gerty, L Jones, DG Evans, L Haywood, I Campbell

Journal article  |  2016  |  Annals of Oncology

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BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers

Huong D Meeks, Honglin Song, Kyriaki Michailidou, Manjeet K Bolla, Joe Dennis, Qin Wang, Daniel Barrowdale, Debra Frost, Lesley McGuffog, Steve Ellis, Bingjian Feng, Saundra S Buys, John L Hopper, Melissa C Southey, Andrea Tesoriero, Paul A James, Fiona Bruinsma, Ian G Campbell, Annegien Broeks, Marjanka K Schmidt, et al.

Journal article  |  2016  |  Journal of the National Cancer Institute

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Genomic Analysis

SM Hunter, AE McCart Reed, IG Campbell, KL Gorringe

Book Chapter  |  2016

The aim of the book is to discuss the application of molecular pathology in cancer research, and its contribution in the classific..

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Evidence of a genetic link between endometriosis and ovarian cancer

Alice W Lee, Claire Templeman, Douglas A Stram, Jonathan Beesley, Jonathan Tyrer, Andrew Berchuck, Paul P Pharoah, Georgia Chenevix-Trench, Celeste Leigh Pearce

Journal article  |  2016  |  Fertility and Sterility

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Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families

Jun Li, Huong Meeks, Bing-Jian Feng, Sue Healey, Heather Thorne, Igor Makunin, Jonathan Ellis, Ian Campbell, Melissa Southey, Gillian Mitchell, David Clouston, Judy Kirk, David Goldgar, Georgia Chenevix-Trench

Journal article  |  2016  |  Journal of Medical Genetics

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Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium

Sharon E Johnatty, Jonathan P Tyrer, Siddhartha Kar, Jonathan Beesley, Yi Lu, Bo Gao, Peter A Fasching, Alexander Hein, Arif B Ekici, Matthias W Beckmann, Diether Lambrechts, Els Van Nieuwenhuysen, Ignace Vergote, Sandrina Lambrechts, Mary Anne Rossing, Jennifer A Doherty, Jenny Chang-Claude, Francesmary Modugno, Roberta B Ness, Kirsten B Moysich, et al.

Journal article  |  2015  |  Clinical Cancer Research

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Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk

Ernest K Amankwah, Hui-Yi Lin, Jonathan P Tyrer, Kate Lawrenson, Joe Dennis, Ganna Chornokur, Katja KH Aben, Hoda Anton-Culver, Natalia Antonenkova, Fiona Bruinsma, Elisa V Bandera, Yukie T Bean, Matthias W Beckmann, Maria Bisogna, Line Bjorge, Natalia Bogdanova, Louise A Brinton, Angela Brooks-Wilson, Clareann H Bunker, Ralf Butzow, et al.

Journal article  |  2015  |  Genetic Epidemiology

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Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes

SM Hunter, MS Anglesio, GL Ryland, R Sharma, YE Chiew, SM Rowley, MA Doyle, J Li, CB Gilks, P Moss, PE Allan, AN Stephens, DG Huntsman, A deFazio, DD Bowtell, G Australian Ovarian Cancer Study, KL Gorringe, IG Campbell

Journal article  |  2015  |  Oncotarget

Low grade serous ovarian tumours are a rare and under-characterised histological subtype of epithelial ovarian tumours, with littl..

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Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer

Kate Lawrenson, Edwin S Iversen, Jonathan Tyrer, Rachel Palmieri Weber, Patrick Concannon, Dennis J Hazelett, Qiyuan Li, Jeffrey R Marks, Andrew Berchuck, Janet M Lee, Katja KH Aben, Hoda Anton-Culver, Natalia Antonenkova, Elisa V Bandera, Yukie Bean, Matthias W Beckmann, Maria Bisogna, Line Bjorge, Natalia Bogdanova, Louise A Brinton, et al.

Journal article  |  2015  |  Carcinogenesis

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Reevaluation of the BRCA2 truncating allele c.9976A > T (p.Lys3326Ter) in a familial breast cancer context

Ella R Thompson, Kylie L Gorringe, Simone M Rowley, Na Li, Simone McInerny, Michelle W Wong-Brown, Lisa Devereux, Jason Li, Alison H Trainer, Gillian Mitchell, Rodney J Scott, Paul A James, Ian G Campbell

Journal article  |  2015  |  Sci Rep

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Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour

Katie T Huang, Thomas Mikeska, Jason Li, Elena A Takano, Ewan KA Millar, Peter H Graham, Samantha E Boyle, Ian G Campbell, Terence P Speed, Alexander Dobrovic, Stephen B Fox

Journal article  |  2015  |  BMC Cancer

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Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk

Siddhartha P Kar, Jonathan P Tyrer, Qiyuan Li, Kate Lawrenson, Katja KH Aben, Hoda Anton-Culver, Natalia Antonenkova, Georgia Chenevix-Trench, Helen Baker, Elisa V Bandera, Yukie T Bean, Matthias W Beckmann, Andrew Berchuck, Maria Bisogna, Line Bjorge, Natalia Bogdanova, Louise Brinton, Angela Brooks-Wilson, Ralf Butzow, Ian Campbell, et al.

Journal article  |  2015  |  Cancer Epidemiology Biomarkers & Prevention

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FANCM c.5791C > T nonsense mutation (rs144567652) induces exon skipping, affects DNA repair activity and is a familial breast cancer risk factor

Paolo Peterlongo, Irene Catucci, Mara Colombo, Laura Caleca, Eliseos Mucaki, Massimo Bogliolo, Maria Marin, Francesca Damiola, Loris Bernard, Valeria Pensotti, Sara Volorio, Valentina Dall'Olio, Alfons Meindl, Claus Bartram, Christian Sutter, Harald Surowy, Valerie Sornin, Marie-Gabrielle Dondon, Severine Eon-Marchais, Dominique Stoppa-Lyonnet, et al.

Journal article  |  2015  |  Human Molecular Genetics

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Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

Kate Lawrenson, Qiyan Li, Siddhartha Kar, Ji-Heui Seo, Jonathan Tyrer, Tassja J Spindler, Janet Lee, Yibu Chen, Alison Karst, Ronny Drapkin, Katja KH Aben, Hoda Anton-Culver, Natalia Antonenkova, Helen Baker, Elisa V Bandera, Yukie Bean, Matthias W Beckmann, Andrew Berchuck, Maria Bisogna, Line Bjorge, et al.

Journal article  |  2015  |  Nature Communications

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Copy number analysis of ductal carcinoma in situ with and without recurrence

Kylie L Gorringe, Sally M Hunter, Jia-Min Pang, Ken Opeskin, Prue Hill, Simone M Rowley, David YH Choong, Ella R Thompson, Alexander Dobrovic, Stephen B Fox, G Bruce Mann, Ian G Campbell

Journal article  |  2015  |  Modern Pathology

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Prevalence of PALB2 mutations in Australian familial breast cancer cases and controls

Ella R Thompson, Kylie L Gorringe, Simone M Rowley, Michelle W Wong-Brown, Simone McInerny, Na Li, Alison H Trainer, Lisa Devereux, Maria A Doyle, Jason Li, Richard Lupat, Martin B Delatycki, Gillian Mitchell, Paul A James, Rodney J Scott, Ian G Campbell

Journal article  |  2015  |  Breast Cancer Res

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Mutational landscape of mucinous ovarian carcinoma and its neoplastic precursors

Georgina L Ryland, Sally M Hunter, Maria A Doyle, Franco Caramia, Jason Li, Simone M Rowley, Michael Christie, Prue E Allan, Andrew N Stephens, David DL Bowtell, Ian G Campbell, Kylie L Gorringe

Journal article  |  2015  |  Genome Med

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Loss of heterozygosity: what is it good for?

Georgina L Ryland, Maria A Doyle, David Goode, Samantha E Boyle, David YH Choong, Simone M Rowley, Jason Li, David DL Bowtell, Richard W Tothill, Ian G Campbell, Kylie L Gorringe

Journal article  |  2015  |  BMC Med Genomics

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Genome-wide significant risk associations for mucinous ovarian carcinoma

Linda E Kelemen, Kate Lawrenson, Jonathan Tyrer, Qiyuan Li, Janet M Lee, Ji-Heui Seo, Catherine M Phelan, Jonathan Beesley, Xiaoqing Chen, Tassja J Spindler, Katja KH Aben, Hoda Anton-Culver, Natalia Antonenkova, Helen Baker, Elisa V Bandera, Yukie Bean, Matthias W Beckmann, Maria Bisogna, Line Bjorge, Natalia Bogdanova, et al.

Journal article  |  2015  |  Nature Genetics

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Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

Ganna Chornokur, Hui-Yi Lin, Jonathan P Tyrer, Kate Lawrenson, Joe Dennis, Ernest K Amankwah, Xiaotao Qu, Ya-Yu Tsai, Heather SL Jim, Zhihua Chen, Ann Y Chen, Jennifer Permuth-Wey, Katja KH Aben, Hoda Anton-Culver, Natalia Antonenkova, Fiona Bruinsma, Elisa V Bandera, Yukie T Bean, Matthias W Beckmann, Maria Bisogna, et al.

Journal article  |  2015  |  PLOS ONE

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Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breast

Jia-Min B Pang, Kylie L Gorringe, Stephen Q Wong, Alexander Dobrovic, Ian G Campbell, Stephen B Fox

Journal article  |  2015  |  Breast Cancer Research

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Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition

Sally J Davis, Karen E Sheppard, Michael S Anglesio, Joshy George, Nadia Traficante, Sian Fereday, Maria P Intermaggio, Usha Menon, Aleksandra Gentry-Maharaj, Jan Lubinski, Jacek Gronwald, Celeste Leigh Pearce, Malcolm C Pike, Anna Wu, Stefan Kommoss, Jacobus Pfisterer, Andreas du Bois, Felix Hilpert, Susan J Ramus, David DL Bowtell, et al.

Journal article  |  2015  |  Molecular Cancer Therapeutics

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Low-grade fibromatosis-like spindle cell carcinomas of the breast are molecularly exiguous

Elena A Takano, Sally M Hunter, Ian G Campbell, Stephen B Fox

Journal article  |  2015  |  Journal of Clinical Pathology

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Familial colorectal cancer

MS Lung, AH Trainer, I Campbell, L Lipton

Journal article  |  2015  |  Internal Medicine Journal

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Evaluating the ovarian cancer gonadotropin hypothesis: A candidate gene study

Alice W Lee, Jonathan P Tyrer, Jennifer A Doherty, Douglas A Stram, Jolanta Kupryjanczyk, Agnieszka Dansonka-Mieszkowska, Joanna Plisiecka-Halasa, Beata Spiewankiewicz, Emily J Myers, Georgia Chenevix-Trench, Peter A Fasching, Matthias W Beckmann, Arif B Ekici, Alexander Hein, Ignace Vergote, Els Van Nieuwenhuysen, Diether Lambrechts, Kristine G Wicklund, Ursula Eilber, Shan Wang-Gohrke, et al.

Journal article  |  2015  |  Gynecologic Oncology

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Identification of six new susceptibility loci for invasive epithelial ovarian cancer

Karoline B Kuchenbaecker, Susan J Ramus, Jonathan Tyrer, Andrew Lee, Howard C Shen, Jonathan Beesley, Kate Lawrenson, Lesley McGuffog, Sue Healey, Janet M Lee, Tassja J Spindler, Yvonne G Lin, Tanja Pejovic, Yukie Bean, Qiyuan Li, Simon Coetzee, Dennis Hazelett, Alexander Miron, Melissa Southey, Mary Beth Terry, et al.

Journal article  |  2015  |  Nature Genetics

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Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC).

Heather SL Jim, Hui-Yi Lin, Jonathan P Tyrer, Kate Lawrenson, Joe Dennis, Ganna Chornokur, Zhihua Chen, Ann Y Chen, Jennifer Permuth-Wey, Katja Kh Aben, Hoda Anton-Culver, Natalia Antonenkova, Fiona Bruinsma, Elisa V Bandera, Yukie T Bean, Matthias W Beckmann, Maria Bisogna, Line Bjorge, Natalia Bogdanova, Louise A Brinton, et al.

Journal article  |  2015  |  Journal of Genetics and Genome Research

Disruption in circadian gene expression, whether due to genetic variation or environmental factors (e.g., light at night, shiftwor..

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Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver

Catherine Emmanuel, Yoke-Eng Chiew, Joshy George, Dariush Etemadmoghadam, Michael S Anglesio, Raghwa Sharma, Peter Russell, Catherine Kennedy, Sian Fereday, Jillian Hung, Laura Galletta, Russell Hogg, Gerard V Wain, Alison Brand, Rosemary Balleine, Laura MacConaill, Emanuele Palescandolo, Sally M Hunter, Ian Campbell, Alexander Dobrovic, et al.

Journal article  |  2014  |  Clinical Cancer Research

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Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk

Linda E Kelemen, Kathryn L Terry, Marc T Goodman, Penelope M Webb, Elisa V Bandera, Valerie McGuire, Mary Anne Rossing, Qinggang Wang, Ed Dicks, Jonathan P Tyrer, Honglin Song, Jolanta Kupryjanczyk, Agnieszka Dansonka-Mieszkowska, Joanna Plisiecka-Halasa, Agnieszka Timorek, Usha Menon, Aleksandra Gentry-Maharaj, Simon A Gayther, Susan J Ramus, Steven A Narod, et al.

Journal article  |  2014  |  Molecular Nutrition & Food Research

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Inferring copy number and genotype in tumour exome data

Kaushalya C Amarasinghe, Jason Li, Sally M Hunter, Georgina L Ryland, Prue A Cowin, Ian G Campbell, Saman K Halgamuge

Journal article  |  2014  |  BMC Genomics

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Variation in NF-kappa B Signaling Pathways and Survival in Invasive Epithelial Ovarian Cancer

Matthew S Block, Bridget Charbonneau, Robert A Vierkant, Zachary Fogarty, William R Bamlet, Paul DP Pharoah, Georgia Chenevix-Trench, Mary Anne Rossing, Daniel Cramer, Celeste Leigh Pearce, Joellen Schildkraut, Usha Menon, Susanne K Kjaer, Douglas A Levine, Jacek Gronwald, Hoda Anton Culver, Alice S Whittemore, Beth Y Karlan, Diether Lambrechts, Nicolas Wentzensen, et al.

Journal article  |  2014  |  Cancer Epidemiology Biomarkers & Prevention

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Genomic Aberrations of BRCA1-Mutated Fallopian Tube Carcinomas

Sally M Hunter, Georgina L Ryland, Phillip Moss, Kylie L Gorringe, Ian G Campbell

Journal article  |  2014  |  The American Journal of Pathology

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Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA

Madalene A Earp, Linda E Kelemen, Anthony M Magliocco, Kenneth D Swenerton, Georgia Chenevix-Trench, Yi Lu, Alexander Hein, Arif B Ekici, Matthias W Beckmann, Peter A Fasching, Diether Lambrechts, Evelyn Despierre, Ignace Vergote, Sandrina Lambrechts, Jennifer A Doherty, Mary Anne Rossing, Jenny Chang-Claude, Anja Rudolph, Grace Friel, Kirsten B Moysich, et al.

Journal article  |  2014  |  Human Genetics

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Bioinformatics Pipelines for Targeted Resequencing and Whole-Exome Sequencing of Human and Mouse Genomes: A Virtual Appliance Approach for Instant Deployment

Jason Li, Maria A Doyle, Isaam Saeed, Stephen Q Wong, Victoria Mar, David L Goode, Franco Caramia, Ken Doig, Georgina L Ryland, Ella R Thompson, Sally M Hunter, Saman K Halgamuge, Jason Ellul, Alexander Dobrovic, Ian G Campbell, Anthony T Papenfuss, Grant A McArthur, Richard W Tothill

Journal article  |  2014  |  PLoS One

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Large-Scale Evaluation of Common Variation in Regulatory T Cell-Related Genes and Ovarian Cancer Outcome

Bridget Charbonneau, Kirsten B Moysich, Kimberly R Kalli, Ann L Oberg, Robert A Vierkant, Zachary C Fogarty, Matthew S Block, Matthew J Maurer, Krista M Goergen, Brooke L Fridley, Julie M Cunningham, David N Rider, Claudia Preston, Lynn C Hartmann, Kate Lawrenson, Chen Wang, Jonathan Tyrer, Honglin Song, Anna defazio, Sharon E Johnatty, et al.

Journal article  |  2014  |  Cancer Immunology Research

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Risk of Ovarian Cancer and the NF-kappa B Pathway: Genetic Association with IL1A and TNFSF10

Bridget Charbonneau, Matthew S Block, William R Bamlet, Robert A Vierkant, Kimberly R Kalli, Zachary Fogarty, David N Rider, Thomas A Sellers, Shelley S Tworoger, Elizabeth Poole, Harvey A Risch, Helga B Salvesen, Lambertus A Kiemeney, Laura Baglietto, Graham G Giles, Gianluca Severi, Britton Trabert, Nicolas Wentzensen, Georgia Chenevix-Trench, Alice S Whittemore, et al.

Journal article  |  2014  |  Cancer Research

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A simple consensus approach improves somatic mutation prediction accuracy

David L Goode, Sally M Hunter, Maria A Doyle, Tao Ma, Simone M Rowley, David Choong, Georgina L Ryland, Ian G Campbell

Journal article  |  2013  |  Genome Medicine: medicine in the post-genomic era

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Analysis of Over 10,000 Cases Finds No Association between Previously Reported Candidate Polymorphisms and Ovarian Cancer Outcome

Kristin L White, Robert A Vierkant, Zachary C Fogarty, Bridget Charbonneau, Matthew S Block, Paul DP Pharoah, Georgia Chenevix-Trench, Mary Anne Rossing, Daniel W Cramer, Celeste Leigh Pearce, Joellen M Schildkraut, Usha Menon, Susanne Kruger Kjaer, Douglas A Levine, Jacek Gronwald, Hoda Anton Culver, Alice S Whittemore, Beth Y Karlan, Diether Lambrechts, Nicolas Wentzensen, et al.

Journal article  |  2013  |  Cancer Epidemiology, Biomarkers & Prevention

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GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

Paul DP Pharoah, Ya-Yu Tsai, Susan J Ramus, Catherine M Phelan, Ellen L Goode, Kate Lawrenson, Melissa Buckley, Brooke L Fridley, Jonathan P Tyrer, Howard Shen, Rachel Weber, Rod Karevan, Melissa C Larson, Honglin Song, Daniel C Tessier, Francois Bacot, Daniel Vincent, Julie M Cunningham, Joe Dennis, Ed Dicks, et al.

Journal article  |  2013  |  Nature Genetics

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Human perforin mutations and susceptibility to multiple primary cancers

Joseph A Trapani, Kevin YT Thia, Miles Andrews, Ian D Davis, Craig Gedye, Philip Parente, Suzanne Svobodova, Jenny Chia, Kylie Browne, Ian G Campbell, Wayne A Phillips, Ilia Voskoboinik, Jonathan S Cebon

Journal article  |  2013  |  OncoImmunology

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Functional Analysis of Genes in Regions Commonly Amplified in High-Grade Serous and Endometrioid Ovarian Cancer

Sally J Davis, Karen E Sheppard, Richard B Pearson, Ian G Campbell, Kylie L Gorringe, Kaylene J Simpson

Journal article  |  2013  |  Clinical Cancer Research

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Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer

Hui Shen, Brooke L Fridley, Honglin Song, Kate Lawrenson, Julie M Cunningham, Susan J Ramus, Mine S Cicek, Jonathan Tyrer, Douglas Stram, Melissa C Larson, Martin Koebel, Argyrios Ziogas, Wei Zheng, Hannah P Yang, Anna H Wu, Eva L Wozniak, Yin Ling Woo, Boris Winterhoff, Elisabeth Wik, Alice S Whittemore, et al.

Journal article  |  2013  |  Nature Communications

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Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

Jennifer Permuth-Wey, Kate Lawrenson, Howard C Shen, Aneliya Velkova, Jonathan P Tyrer, Zhihua Chen, Hui-Yi Lin, Y Ann Chen, Ya-Yu Tsai, Xiaotao Qu, Susan J Ramus, Rod Karevan, Janet Lee, Nathan Lee, Melissa C Larson, Katja K Aben, Hoda Anton-Culver, Natalia Antonenkova, Antonis C Antoniou, Sebastian M Armasu, et al.

Journal article  |  2013  |  Nature Communications

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Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

Fergus J Couch, Xianshu Wang, Lesley McGuffog, Andrew Lee, Curtis Olswold, Karoline B Kuchenbaecker, Penny Soucy, Zachary Fredericksen, Daniel Barrowdale, Joe Dennis, Mia M Gaudet, Ed Dicks, Matthew Kosel, Sue Healey, Olga M Sinilnikova, Adam Lee, Francois Bacot, Daniel Vincent, Frans BL Hogervorst, Susan Peock, et al.

Journal article  |  2013  |  PLoS Genetics

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RNF43 is a tumour suppressor gene mutated in mucinous tumours of the ovary

Georgina L Ryland, Sally M Hunter, Maria A Doyle, Simone M Rowley, Michael Christie, Prue E Allan, David DL Bowtell, Kylie L Gorringe, Ian G Campbell

Journal article  |  2013  |  Journal of Pathology

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Analysis of RAD51D in Ovarian Cancer Patients and Families with a History of Ovarian or Breast Cancer

Ella R Thompson, Simone M Rowley, Sarah Sawyer, Diana M Eccles, Alison H Trainer, Gillian Mitchell, Paul A James, Ian G Campbell

Journal article  |  2013  |  PLoS One

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COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration

Melissa C Southey, Daniel J Park, Tu Nguyen-Dumont, Ian Campbell, Ella Thompson, Alison H Trainer, Georgia Chenevix-Trench, Jacques Simard, Martine Dumont, Penny Soucy, Mads Thomassen, Lars Jonson, Inge S Pedersen, Thomas VO Hansen, Heli Nevanlinna, Sofia Khan, Olga Sinilnikova, Sylvie Mazoyer, Fabienne Lesueur, Francesca Damiola, et al.

Journal article  |  2013  |  Breast Cancer Research

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Pre-Invasive Ovarian Mucinous Tumors Are Characterized by CDKN2A and RAS Pathway Aberrations

Sally M Hunter, Kylie L Gorringe, Michael Christie, Simone M Rowley, David D Bowtell, Ian G Campbell

Journal article  |  2012  |  Clinical Cancer Research

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Rare variants in XRCC2 as breast cancer susceptibility alleles

Florentine S Hilbers, Juul T Wijnen, Nicoline Hoogerbrugge, Jan C Oosterwijk, Margriet J Collee, Paolo Peterlongo, Paolo Radice, Siranoush Manoukian, Irene Feroce, Fabio Capra, Fergus J Couch, Xianshu Wang, Lucia Guidugli, Kenneth Offit, Sohela Shah, Ian G Campbell, Ella R Thompson, Paul A James, Alison H Trainer, Javier Gracia, et al.

Journal article  |  2012  |  Journal of Medical Genetics

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Exome Sequencing Identifies Rare Deleterious Mutations in DNA Repair Genes FANCC and BLM as Potential Breast Cancer Susceptibility Alleles

Ella R Thompson, Maria A Doyle, Georgina L Ryland, Simone M Rowley, David YH Choong, Richard W Tothill, Heather Thorne, Daniel R Barnes, Jason Li, Jason Ellul, Gayle K Philip, Yoland C Antill, Paul A James, Alison H Trainer, Gillian Mitchell, Ian G Campbell

Journal article  |  2012  |  PLoS Genetics

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High and low mammographic density human breast tissues maintain histological differential in murine tissue engineering chambers

GL Chew, D Huang, SJ Lin, C Huo, T Blick, MA Henderson, P Hill, J Cawson, WA Morrison, IG Campbell, JL Hopper, MC Southey, I Haviv, EW Thompson

Journal article  |  2012  |  Breast Cancer Research and Treatment

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The molecular characterisation of unusual subcutaneous spindle cell lesion of breast

Elena A Takano, Toni-Maree Rogers, Richard J Young, Mukta Rayoo, Phillip Kostos, Ross Ferguson, Ian G Campbell, Maria Debiec-Rychter, Stephen B Fox

Journal article  |  2012  |  Journal of Clinical Pathology

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Analysis of KLLN as a high-penetrance breast cancer predisposition gene

Ella R Thompson, Kylie L Gorringe, David YH Choong, Diana M Eccles, Gillian Mitchell, Ian G Campbell

Journal article  |  2012  |  Breast Cancer Research and Treatment

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Identification of copy number alterations associated with the progression of DCIS to invasive ductal carcinoma

Clint E Johnson, Kylie L Gorringe, Ella R Thompson, Ken Opeskin, Samantha E Boyle, Yuker Wang, Prue Hill, G Bruce Mann, Ian G Campbell

Journal article  |  2012  |  Breast Cancer Research and Treatment

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CONTRA: copy number analysis for targeted resequencing

Jason Li, Richard Lupat, Kaushalya C Amarasinghe, Ella R Thompson, Maria A Doyle, Georgina L Ryland, Richard W Tothill, Saman K Halgamuge, Ian G Campbell, Kylie L Gorringe

Journal article  |  2012  |  Bioinformatics

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MicroRNA Genes and Their Target 3 '-Untranslated Regions Are Infrequently Somatically Mutated in Ovarian Cancers

Georgina L Ryland, Jennifer L Bearfoot, Maria A Doyle, Samantha E Boyle, David YH Choong, Simone M Rowley, Richard W Tothill, Kylie L Gorringe, Ian G Campbell

Journal article  |  2012  |  PLoS One

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An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

Kathryn M Kinross, Karen G Montgomery, Margarete Kleinschmidt, Paul Waring, Ivan Ivetac, Anjali Tikoo, Mirette Saad, Lauren Hare, Vincent Roh, Theo Mantamadiotis, Karen E Sheppard, Georgina L Ryland, Ian G Campbell, Kylie L Gorringe, James G Christensen, Carleen Cullinane, Rodney J Hicks, Richard B Pearson, Ricky W Johnstone, Grant A McArthur, et al.

Journal article  |  2012  |  Journal of Clinical Investigation

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Analysis of RAD51C Germline Mutations in High-Risk Breast and Ovarian Cancer Families and Ovarian Cancer Patients

Ella R Thompson, Samantha E Boyle, Julie Johnson, Georgina L Ryland, Sarah Sawyer, David YH Choong, Georgia Chenevix-Trench, Alison H Trainer, Geoffrey J Lindeman, Gillian Mitchell, Paul A James, Ian G Campbell

Journal article  |  2012  |  Human Mutation

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Copy Number Aberrations in Benign Serous Ovarian Tumors: A Case for Reclassification?

Sally M Hunter, Michael S Anglesio, Raghwa Sharma, C Blake Gilks, Nataliya Melnyk, Yoke-Eng Chiew, Anna deFazio, Teri A Longacre, David G Huntsman, Kylie L Gorringe, Ian G Campbell

Journal article  |  2011  |  Clinical Cancer Research

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Functional Polymorphisms in the TERT Promoter Are Associated with Risk of Serous Epithelial Ovarian and Breast Cancers

Jonathan Beesley, Hilda A Pickett, Sharon E Johnatty, Alison M Dunning, Xiaoqing Chen, Jun Li, Kyriaki Michailidou, Yi Lu, David N Rider, Rachel T Palmieri, Michael D Stutz, Diether Lambrechts, Evelyn Despierre, Sandrina Lambrechts, Ignace Vergote, Jenny Chang-Claude, Stefan Nickels, Alina Vrieling, Dieter Flesch-Janys, Shan Wang-Gohrke, et al.

Journal article  |  2011  |  PLoS ONE

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Image-guided sampling reveals increased stroma and lower glandular complexity in mammographically dense breast tissue

Suling J Lin, Jennifer Cawson, Prue Hill, Izhak Haviv, Mark Jenkins, John L Hopper, Melissa C Southey, Ian G Campbell, Erik W Thompson

Journal article  |  2011  |  Breast Cancer Research and Treatment

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The Role of KRAS rs61764370 in Invasive Epithelial Ovarian Cancer: Implications for Clinical Testing

Paul DP Pharoah, Rachel T Palmieri, Susan J Ramus, Simon A Gayther, Irene L Andrulis, Hoda Anton-Culver, Natalia Antonenkova, Antonis C Antoniou, David Goldgar, Mary S Beattie, Matthias W Beckmann, Michael J Birrer, Natalia Bogdanova, Kelly L Bolton, Wendy Brewster, Angela Brooks-Wilson, Robert Brown, Ralf Butzow, Trinidad Caldes, Maria Adelaide Caligo, et al.

Journal article  |  2011  |  Clinical Cancer Research

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Polymorphisms in Stromal Genes and Susceptibility to Serous Epithelial Ovarian Cancer: A Report from the Ovarian Cancer Association Consortium

Ernest K Amankwah, Qinggang Wang, Joellen M Schildkraut, Ya-Yu Tsai, Susan J Ramus, Brooke L Fridley, Jonathan Beesley, Sharon E Johnatty, Penelope M Webb, Georgia Chenevix-Trench, Laura C Dale, Diether Lambrechts, Frederic Amant, Evelyn Despierre, Ignace Vergote, Simon A Gayther, Aleksandra Gentry-Maharaj, Usha Menon, Jenny Chang-Claude, Shan Wang-Gohrke, et al.

Journal article  |  2011  |  PLoS One

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Analysis of the Mitogen-activated protein kinase kinase 4 (MAP2K4) tumor suppressor gene in ovarian cancer

Sally J Davis, David YH Choong, Manasa Ramakrishna, Georgina L Ryland, Ian G Campbell, Kylie L Gorringe

Journal article  |  2011  |  BMC Cancer

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SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer

Marjan E Askarian-Amiri, Joanna Crawford, Juliet D French, Chanel E Smart, Martin A Smith, Michael B Clark, Kelin Ru, Tim R Mercer, Ella R Thompson, Sunil R Lakhani, Ana C Vargas, Ian G Campbell, Melissa A Brown, Marcel E Dinger, John S Mattick

Journal article  |  2011  |  RNA

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IL6-STAT3-HIF Signaling and Therapeutic Response to the Angiogenesis Inhibitor Sunitinib in Ovarian Clear Cell Cancer

Michael S Anglesio, Joshy George, Hagen Kulbe, Michael Friedlander, Danny Rischin, Charlotte Lemech, Jeremy Power, Jermaine Coward, Prue A Cowin, Colin M House, Probir Chakravarty, Kylie L Gorringe, Ian G Campbell, Aikou Okamoto, Michael J Birrer, David G Huntsman, Anna de Fazio, Steve E Kalloger, Frances Balkwill, C Blake Gilks, et al.

Journal article  |  2011  |  Clinical Cancer Research

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Genetic changes in tumour microenvironments

Ian Campbell, Wen Qiu, Izhak Haviv

Journal article  |  2011  |  Journal of Pathology

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Common variants at 19p13 are associated with susceptibility to ovarian cancer

Kelly L Bolton, Jonathan Tyrer, Honglin Song, Susan J Ramus, Maria Notaridou, Chris Jones, Tanya Sher, Aleksandra Gentry-Maharaj, Eva Wozniak, Ya-Yu Tsai, Joanne Weidhaas, Daniel Paik, David J Van den Berg, Daniel O Stram, Celeste Leigh Pearce, Anna H Wu, Wendy Brewster, Hoda Anton-Culver, Argyrios Ziogas, Steven A Narod, et al.

Journal article  |  2010  |  Nature Genetics

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A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24

Llen L Goode, Georgia Chenevix-Trench, Honglin Song, Susan J Ramus, Maria Notaridou, Kate Lawrenson, Martin Widschwendter, Robert A Vierkant, Melissa C Larson, Susanne K Kjaer, Michael J Birrer, Andrew Berchuck, Joellen Schildkraut, Ian Tomlinson, Lambertus A Kiemeney, Linda S Cook, Jacek Gronwald, Montserrat Garcia-Closas, Martin E Gore, Ian Campbell, et al.

Journal article  |  2010  |  Nature Genetics

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Copy Number Analysis Identifies Novel Interactions Between Genomic Loci in Ovarian Cancer

Kylie L Gorringe, Joshy George, Michael S Anglesio, Manasa Ramakrishna, Dariush Etemadmoghadam, Prue Cowin, Anita Sridhar, Louise H Williams, Samantha E Boyle, Nozomu Yanaihara, Aikou Okamoto, Mitsuyoshi Urashima, Gordon K Smyth, Ian G Campbell, David DL Bowtell

Journal article  |  2010  |  PLoS One

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Exploiting sequence similarity to validate the sensitivity of SNP arrays in detecting fine-scaled copy number variations

Gerard Wong, Christopher Leckie, Kylie L Gorringe, Izhak Haviv, Ian G Campbell, Adam Kowalczyk

Journal article  |  2010  |  Bioinformatics

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Identification of Candidate Growth Promoting Genes in Ovarian Cancer through Integrated Copy Number and Expression Analysis

Manasa Ramakrishna, Louise H Williams, Samantha E Boyle, Jennifer L Bearfoot, Anita Sridhar, Terence P Speed, Kylie L Gorringe, Ian G Campbell

Journal article  |  2010  |  PLoS One

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FGFR2 mutations are rare across histologic subtypes of ovarian cancer

Sara A Byron, Michael G Gartside, Candice L Wellens, Paul J Goodfellow, Michael J Birrer, Ian G Campbell, Pamela M Pollock

Journal article  |  2010  |  Gynecologic Oncology

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MIRAGAA-a methodology for finding coordinated effects of microRNA expression changes and genome aberrations in cancer

Raj K Gaire, James Bailey, Jennifer Bearfoot, Ian G Campbell, Peter J Stuckey, Izhak Haviv

Journal article  |  2010  |  Bioinformatics

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Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors

Jeremy M Arnold, David YH Choong, Ella R Thompson, Nic Waddell, Geoffrey J Lindeman, Jane E Visvader, Ian G Campbell, Georgia Chenevix-Trench

Journal article  |  2010  |  Breast Cancer Research and Treatment

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Gene Methylation in Breast Ductal Fluid from BRCA1 and BRCA2 Mutation Carriers

Yoland C Antill, Gillian Mitchell, Sandra A Johnson, Lisa Devereux, Alvin Milner, Juliana Di Iuiio, Geoffrey J Lindeman, Judy Kirk, Kelly Anne Phillips, Ian G Campbell

Journal article  |  2010  |  Cancer Epidemiology, Biomarkers & Prevention

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Are There Any More Ovarian Tumor Suppressor Genes? A New Perspective Using Ultra High-Resolution Copy Number and Loss of Heterozygosity Analysis

Kylie L Gorringe, Manasa Ramakrishna, Louise H Williams, Anita Sridhar, Samantha E Boyle, Jennifer L Bearfoot, Jason Li, Michael S Anglesio, Ian G Campbell

Journal article  |  2009  |  Genes, Chromosomes & Cancer

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Clonal Mutations in the Cancer-Associated Fibroblasts: The Case against Genetic Coevolution

Ian Campbell, Kornelia Polyak, Izhak Haviv

Journal article  |  2009  |  Cancer Research

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Large-scale genomic analysis of ovarian carcinomas

Kylie L Gorringe, Ian G Campbell

Journal article  |  2009  |  Molecular Oncology

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Origin of carcinoma associated fibroblasts

Izhak Haviv, Kornelia Polyak, Wen Qiu, Min Hu, Ian Campbell

Journal article  |  2009  |  Cell Cycle

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Co-evolution of tumor cells and their microenvironment

Kornelia Polyak, Izhak Haviv, Ian G Campbell

Journal article  |  2009  |  Trends in Genetics

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Genetic Analysis of Cancer-implicated MicroRNA in Ovarian Cancer

Jennifer L Bearfoot, David YH Choong, Kylie L Gorringe, Ian G Campbell

Journal article  |  2008  |  Clinical Cancer Research

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High-resolution copy number arrays in cancer and the problem of normal genome copy number variation

Kylie L Gorringe, Ian G Campbell

Journal article  |  2008  |  Genes, Chromosomes & Cancer

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Breast cancer risk and the BRCA1 interacting protein CTIP

Kylie L Gorringe, David YH Choong, Geoffrey J Lindeman, Jane E Visvader, Ian G Campbell

Journal article  |  2008  |  Breast Cancer Research and Treatment

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BARD1 variants are not associated with breast cancer risk in Australian familial breast cancer

Kylie L Gorringe, David YH Choong, Jane E Visvader, Geoffrey J Lindeman, Ian G Campbell

Journal article  |  2008  |  Breast Cancer Research and Treatment

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No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas

Wen Qiu, Min Hu, Anita Sridhar, Ken Opeskin, Stephen Fox, Michail Shipitsin, Melanie Trivett, Ella R Thompson, Manasa Ramakrishna, Kylie L Gorringe, Kornelia Polyak, Izhak Haviv, Ian G Campbell

Journal article  |  2008  |  Nature Genetics

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Breast-cancer stromal cells with TP53 mutations

Ian G Campbell, Wen Qiu, Kornelia Polyak, Izhak Haviv

Journal article  |  2008  |  New England Journal of Medicine

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A rational approach to cancer therapy.

Kylie L Gorringe, Ian G Campbell

Journal article  |  2008  |  Genome Biology

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Genome-wide association study identifies novel breast cancer susceptibility loci

Douglas F Easton, Karen A Pooley, Alison M Dunning, Paul DP Pharoah, Deborah Thompson, Dennis G Ballinger, Jeffery P Struewing, Jonathan Morrison, Helen Field, Robert Luben, Nicholas Wareham, Shahana Ahmed, Catherine S Healey, Richard Bowman, Kerstin B Meyer, Christopher A Haiman, Laurence K Kolonel, Brian E Henderson, Loic Le Marchand, Paul Brennan, et al.

Journal article  |  2007  |  Nature

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ST7-mediated suppression of tumorigenicity of prostate cancer cells is characterized by remodeling of the extracellular matrix

CS-F Hooi, C Blancher, W Qiu, IM Revet, LH Williams, ML Ciavarella, RL Anderson, EW Thompson, A Connor, WA Phillips, IG Campbell

Journal article  |  2006  |  Oncogene

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Common origins of MDA-MB-435 cells from various sources with those shown to have melonoma properties

JM Rae, SJ Ramus, M Waltham, JE Armes, IG Campbell, R Clarke, RJ Barndt, MD Johnson, EW Thompson

Journal article  |  2004  |  Clinical and Experimental Metastasis

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The phosphatidylinositol 3 '-kinase p85 alpha gene is an oncogene in human ovarian and colon tumors

AJ Philp, IG Campbell, C Leet, E Vincan, SP Rockman, RH Whitehead, RJS Thomas, WA Phillips

Journal article  |  2001  |  Cancer Research

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Scholarly Works

Keyword Analysis

Oncology and Carcinogenesis
Clinical Health (organs, Diseases and Abnormal Conditions)
Expanding Knowledge
Genetics
Public Health and Health Services
Biochemistry and Cell Biology
Clinical Sciences
Clinical (organs, Diseases and Abnormal Conditions)
Computer Software
Immunology

Credentials

Positions

Honorary

The Sir Peter Maccallum Department Of Oncology

Honorary

Clinical Pathology

Education

Doctor of Philosophy

The University of Western Australia

Bachelor of Science (Hons)

The University of Western Australia

Links