Sof Andrikopoulos

Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution

Yann W Yap, Patricia M Rusu, Andrea Y Chan, Barbara C Fam, Andreas Jungmann, Samantha M Solon-Biet, Christopher K Barlow, Darren J Creek, Cheng Huang, Ralf B Schittenhelm, Bruce Morgan, Dieter Schmoll, Bente Kiens, Matthew DW Piper, Mathias Heikenwaelder, Stephen J Simpson, Stefan Broer, Sofianos Andrikopoulos, Oliver J Mueller, Adam J Rose

Journal article  |  2020  |  Nature Communications

Dietary protein dilution (DPD) promotes metabolic-remodelling and -health but the precise nutritional components driving this resp..

The association of smoking status with glycemic control, metabolic profile and diabetic complications- Results of the Australian National Diabetes Audit (ANDA).

N Szwarcbard, M Villani, A Earnest, J Flack, S Andrikopoulos, N Wischer, G Soldatos, D Gasevic, S Zoungas

Journal article  |  2020  |  Journal of Diabetes and its Complications

BACKGROUND: Tobacco smoking and diabetes mellitus contribute significantly to the overall health burden and mortality of Australia..

Impaired exercise performance is independent of inflammation and cellular stress following genetic reduction or deletion of selenoprotein S

Alex Bernard Addinsall, Craig Robert Wright, Taryan L Kotsiakos, Zoe M Smith, Taylah R Cook, Sofianos Andrikopoulos, Chris van der Poel, Nicole Stupka

Journal article  |  2020  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Selenoprotein S (Seps1) can be protective against oxidative, endoplasmic reticulum (ER), and inflammatory stress. Seps1 global kno..

E2f8 and Dlg2 genes have independent effects on impaired insulin secretion associated with hyperglycaemia

Chieh-Hsin Yang, Salvatore P Mangiafico, Michaela Waibel, Thomas Loudovaris, Kim Loh, Helen E Thomas, Grant Morahan, Sofianos Andrikopoulos

Journal article  |  2020  |  Diabetologia

AIMS/HYPOTHESIS: Reduced insulin secretion results in hyperglycaemia and diabetes involving a complex aetiology that is yet to be ..

Breathing life into Australian diabetes clinical guidelines

Heath White, Britta Tendal, Julian Elliott, Tari Turner, Sofianos Andrikopoulos, Sophia Zoungas

Journal article  |  2020  |  Medical Journal of Australia

Continuing the success of Journal of Endocrinology and Journal of Molecular Endocrinology.

S Andrikopoulos, C Farquharson, M Haluzik

Journal article  |  2020  |  Journal of Endocrinology

Metformin: time to review its role and safety in chronic kidney disease

Cara Tanner, Gayathiri Wang, Nancy Liu, Sofianos Andrikopoulos, Jeffrey D Zajac, Elif I Ekinci

Journal article  |  2019  |  Medical Journal of Australia

Loss of growth hormone-mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity

Yash Chhabra, Caroline N Nelson, Monika Plescher, Johanna L Barclay, Aaron G Smith, Sof Andrikopoulos, Salvatore Mangiafico, David J Waxman, Andrew J Brooks, Michael J Waters

Journal article  |  2019  |  The FASEB Journal

Four weeks of exercise early in life reprograms adult skeletal muscle insulin resistance caused by a paternal high-fat diet

Filippe Falcao-Tebas, Jujiao Kuang, Chelsea Arceri, Jarrod P Kerris, Sofianos Andrikopoulos, Evelyn C Marin, Glenn K McConell

Journal article  |  2019  |  The Journal of Physiology

Insulin regulates POMC neuronal plasticity to control glucose metabolism

Garron T Dodd, Natalie J Michael, Robert S Lee-Young, Salvatore P Mangiafico, Jack T Pryor, Astrid C Munder, Stephanie E Simonds, Jens Claus Bruening, Zhong-Yin Zhang, Michael A Cowley, Sofianos Andrikopoulos, Tamas L Horvath, David Spanswick, Tony Tiganis

Journal article  |  2018  |  eLife

Age-related differences in glycaemic control, cardiovascular disease risk factors and treatment in patients with type 2 diabetes: a cross-sectional study from the Australian National Diabetes Audit.

Natalie Nanayakkara, Sanjeeva Ranasinha, Adelle M Gadowski, Wendy A Davis, Jeffrey Ronald Flack, Natalie Wischer, Sof Andrikopoulos, Sophia Zoungas

Journal article  |  2018  |  BMJ Open

OBJECTIVE: To compare the glycaemic control and cardiovascular risk factor profiles of younger and older patients with type 2 diab..

Deficiency of selenoprotein S, an endoplasmic reticulum resident oxidoreductase, impairs the contractile function of fast-twitch hindlimb muscles

Alex B Addinsall, Craig R Wright, Chris S Shaw, Natasha L McRae, Leonard G Forgan, Chia-Heng Weng, Xavier A Conlan, Paul S Francis, Zoe M Smith, Sofianos Andrikopoulos, Nicole Stupka

Journal article  |  2018  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Younger people with Type 2 diabetes have poorer self-care practices compared with older people: results from the Australian National Diabetes Audit.

N Nanayakkara, AJ Pease, S Ranasinha, N Wischer, S Andrikopoulos, B de Courten, S Zoungas

Journal article  |  2018  |  Diabetic Medicine

AIM: This cross-sectional study compares the self-care practices of younger and older people with Type 2 diabetes. METHODS: Data w..

Probing the correlation between insulin activity and structural stability through introduction of the rigid A6-A11 bond

Shee Chee Ong, Alessia Belgi, Bianca van Lierop, Carlie Delaine, Sofianos Andrikopoulos, Christopher A MacRaild, Raymond S Norton, Naomi L Haworth, Andrea J Robinson, Briony E Forbes

Journal article  |  2018  |  Journal of Biological Chemistry

Risk-adjustment of diabetes health outcomes improves the accuracy of performance benchmarking

Eleanor Danek, Arul Earnest, Natalie Wischer, Sofianos Andrikopoulos, Anthony Pease, Natalie Nanayakkara, Sophia Zoungas

Journal article  |  2018  |  Scientific Reports

Burden of cardiovascular risk factors and disease among patients with type 1 diabetes: results of the Australian National Diabetes Audit (ANDA)

Anthony Pease, Arul Earnest, Sanjeeva Ranasinha, Natalie Nanayakkara, Danny Liew, Natalie Wischer, Sofianos Andrikopoulos, Sophia Zoungas

Journal article  |  2018  |  Cardiovascular Diabetology

Depression and diabetes distress in adults with type 2 diabetes: results from the Australian National Diabetes Audit (ANDA) 2016

Natalie Nanayakkara, Anthony Pease, Sanjeeva Ranasinha, Natalie Wischer, Sofianos Andrikopoulos, Jane Speight, Barbora de Courten, Sophia Zoungas

Journal article  |  2018  |  Scientific Reports

The androgen receptor in bone marrow progenitor cells negatively regulates fat mass

Patricia K Russell, Salvatore Mangiafico, Barbara C Fam, Michele V Clarke, Evelyn S Marin, Sofianos Andrikopoulos, Kristine M Wiren, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2018  |  Journal of Endocrinology

Emerging roles of endoplasmic reticulum-resident selenoproteins in the regulation of cellular stress responses and the implications for metabolic disease

Alex B Addinsall, Craig R Wright, Sof Andrikopoulos, Chris van der Poel, Nicole Stupka

Journal article  |  2018  |  Biochemical Journal

Ferroportin Expression in Adipocytes Does Not Contribute to Iron Homeostasis or Metabolic Responses to a High Calorie Diet

Laurence Britton, Lesley-Anne Jaskowski, Kim Bridle, Eriza Secondes, Daniel Wallace, Nishreen Santrampurwala, Janske Reiling, Gregory Miller, Salvatore Mangiafico, Sofianos Andrikopoulos, V Nathan Subramaniam, Darrell Crawford

Journal article  |  2018  |  Cellular and Molecular Gastroenterology and Hepatology

RACGP and ADS joint clinical position statement: Emergency management of hyperglycaemia in primary care

G Deed, J Manski-Nankervis, J Barlow, S Zoungas, S Andrikopoulos, L Davis, S Price, J Shaw, S Twigg

Report  |  2018

Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity

Bianca van Lierop, Shee Chee Ong, Alessia Belgi, Carlie Delaine, Sofianos Andrikopoulos, Naomi L Haworth, John G Menting, Michael C Lawrence, Andrea J Robinson, Briony E Forbes

Journal article  |  2017  |  Scientific Reports

Diabetic ketoacidosis in acromegaly; a rare complication precipitated by corticosteroid use

Jeremy Weiss, Anna J Wood, Jeffrey D Zajac, Mathis Grossmann, Sofianos Andrikopoulos, Elif I Ekinci

Journal article  |  2017  |  Diabetes Research and Clinical Practice

Metabolomic analysis of insulin resistance across different mouse strains and diets

Jacqueline Stockli, Kelsey H Fisher-Wellman, Rima Chaudhuri, Xiao-Yi Zeng, Daniel J Fazakerley, Christopher C Meoli, Kristen C Thomas, Nolan J Hoffman, Salvatore P Mangiafico, Chrysovalantou E Xirouchaki, Chieh-Hsin Yang, Olga Ilkayeva, Kari Wong, Gregory J Cooney, Sofianos Andrikopoulos, Deborah M Muoio, David E James

Journal article  |  2017  |  Journal of Biological Chemistry

Dapagliflozin improves insulin resistance and glucose intolerance in a novel transgenic rat model of chronic glucose overproduction and glucose toxicity

Christos N Joannides, Salvatore P Mangiafico, Matthew F Waters, Benjamin J Lamont, Sofianos Andrikopoulos

Journal article  |  2017  |  Diabetes, Obesity and Metabolism

Narrow-leafed lupin (Lupinus angustifolius L.) beta-conglutin proteins modulate the insulin signaling pathway as potential type 2 diabetes treatment and inflammatory-related disease amelioration

Elena Lima-Cabello, Victor Alche, Rhonda C Foley, Sofianos Andrikopoulos, Grant Morahan, Karam B Singh, Juan D Alche, Jose C Jimenez-Lopez

Journal article  |  2017  |  Molecular Nutrition & Food Research

High fat feeding unmasks variable insulin responses in male C57BL/6 mouse substrains

Rebecca L hull, Joshua R Willard, Matthias D Struck, Breanne M Barrow, Gurkirat S Brar, Sofianos Andrikopoulos, Sakeneh Zraika

Journal article  |  2017  |  Journal of Endocrinology

A Reduction in Selenoprotein S Amplifies the Inflammatory Profile of Fast-Twitch Skeletal Muscle in the mdx Dystrophic Mouse

Craig Robert Wright, Giselle Larissa Allsopp, Alex Bernard Addinsall, Natasha Lee McRae, Sofianos Andrikopoulos, Nicole Stupka

Journal article  |  2017  |  MEDIATORS OF INFLAMMATION

Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice (vol 59, pg 2632, 2016)

Troy L Merry, Melanie Tran, Garron T Dodd, Salvatore P Mangiafico, Florian Wiede, Supreet Kaur, Catriona L McLean, Sofianos Andrikopoulos, Tony Tiganis

Journal article  |  2016  |  Diabetologia

Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice

Troy L Merry, Melanie Tran, Garron T Dodd, Salvatore P Mangiafico, Florian Wiede, Supreet Kaur, Catriona L McLean, Sofianos Andrikopoulos, Tony Tiganis

Journal article  |  2016  |  Diabetologia

Monotreme glucagon-like peptide-1 in venom and gut: one gene - two very different functions

Enkhjargal Tsend-Ayush, Chuan He, Mark A Myers, Sof Andrikopoulos, Nicole Wong, Patrick M Sexton, Denise Wootten, Briony E Forbes, Frank Grutzner

Journal article  |  2016  |  Scientific Reports

Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease

Christopher Leung, Chandana B Herath, Zhiyuan Jia, Sof Andrikopoulos, Bronwyn E Brown, Michael J Davies, Leni R Rivera, John B Furness, Josephine M Forbes, Peter W Angus

Journal article  |  2016  |  WORLD JOURNAL OF GASTROENTEROLOGY

The Paleo diet and diabetes

Sofianos Andrikopoulos

Journal article  |  2016  |  Medical Journal of Australia

The paleo diet and diabetes: Studies are inconclusive about the benefits of the paleo diet in patients with type 2 diabetes

S Andrikopoulos

Journal article  |  2016  |  Medical Journal of Australia

Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice

Chrysovalantou E Xirouchaki, Salvatore P Mangiafico, Katherine Bate, Zheng Ruan, Amy M Huang, Bing Wilari Tedjosiswoyo, Benjamin Lamont, Wynne Pong, Jenny Favaloro, Amy R Blair, Jeffrey D Zajac, Joseph Proietto, Sofianos Andrikopoulos

Journal article  |  2016  |  Molecular Metabolism

A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or beta-cell mass in NZO mice

BJ Lamont, MF Waters, S Andrikopoulos

Journal article  |  2016  |  Nutrition & Diabetes

Chewing the fat for better insulin secretion

Sofianos Andrikopoulos

Journal article  |  2016  |  Molecular Metabolism

Identification of ABCC8 as a contributory gene to impaired early-phase insulin secretion in NZO mice

Sofianos Andrikopoulos, Barbara C Fam, Anita Holdsworth, Sherley Visinoni, Zheng Ruan, Maria Stathopoulos, Anne W Thorburn, Christos N Joannides, Michael Cancilla, Lois Balmer, Joseph Proietto, Grant Morahan

Journal article  |  2016  |  Journal of Endocrinology

A bright future ahead for Journal of Molecular Endocrinology.

Adrian Clark, Sof Andrikopoulos

Journal article  |  2015  |  Journal of Molecular Endocrinology

Contribution of the hypothalamus and gut to weight gain susceptibility and resistance in mice

Barbara C Fam, Rebecca Sgambellone, Zheng Ruan, Joseph Proietto, Sofianos Andrikopoulos

Journal article  |  2015  |  JOURNAL OF ENDOCRINOLOGY

Ubiquitous expression of the Pik3ca(H1047R) mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly

Kathryn M Kinross, Karen G Montgomery, Salvatore P Mangiafico, Lauren M Hare, Margarete Kleinschmidt, Megan J Bywater, Ingrid J Poulton, Christina Vrahnas, Holger Henneicke, Jordane Malaterre, Paul M Waring, Carleen Cullinane, Natalie A Sims, Grant A McArthur, Sofianos Andrikopoulos, Wayne A Phillips

Journal article  |  2015  |  FASEB JOURNAL

Improving Glucose Tolerance by Reducing Weight Gain in a Polygenic Obese Mouse Model: Use of a High Protein Diet

AR Blair, ML Strube, J Proietto, S Andrikopoulos

Journal article  |  2015  |  Hormone and Metabolic Research

A bright future ahead for Journal of Endocrinology

A Clark, S Andrikopoulos

Journal article  |  2015  |  Journal of Endocrinology

The Proliferative Gene Cyclin D1 and Gluconeogenesis-Could Suppressing Glucose Production Also Promote Cancer?

Sofianos Andrikopoulos

Journal article  |  2014  |  Diabetes

Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction

Lindsay E Wu, Christopher C Meoli, Salvatore P Mangiafico, Daniel J Fazakerley, Victoria C Cogger, Mashani Mohamad, Himani Pant, Myung-Jin Kang, Elizabeth Powter, James G Burchfield, Chrysovalantou E Xirouchaki, A Stefanie Mikolaizak, Jacqueline Stoeckli, Ganesh Kolumam, Nicholas van Bruggen, Jennifer R Gamble, David G Le Couteur, Gregory J Cooney, Sofianos Andrikopoulos, David E James

Journal article  |  2014  |  Diabetes

Damage to enteric neurons occurs in mice that develop fatty liver disease but not diabetes in response to a high-fat diet

LR Rivera, C Leung, RV Pustovit, BL Hunne, S Andrikopoulos, C Herath, A Testro, PW Angus, JB Furness

Journal article  |  2014  |  Neurogastroenterology & Motility

Hepatic Oxidative Stress Promotes Insulin-STAT-5 Signaling and Obesity by Inactivating Protein Tyrosine Phosphatase N2

Esteban N Gurzov, Melanie Tran, Manuel A Fernandez-Rojo, Troy L Merry, Xinmei Zhang, Yang Xu, Atsushi Fukushima, Michael J Waters, Matthew J Watt, Sofianos Andrikopoulos, Benjamin G Neel, Tony Tiganis

Journal article  |  2014  |  Cell Metabolism

High-Fat-Fed Obese Glutathione Peroxidase 1-Deficient Mice Exhibit Defective Insulin Secretion but Protection from Hepatic Steatosis and Liver Damage

Troy L Merry, Melanie Tran, Maria Stathopoulos, Florian Wiede, Barbara Christianne Fam, Garron T Dodd, Iain Clarke, Matthew J Watt, Sofianos Andrikopoulos, Tony Tiganis

Journal article  |  2014  |  Antioxidants & Redox Signaling

Hope and fear for new classes of type 2 diabetes drugs: is there preclinical evidence that incretin-based therapies alter pancreatic morphology?

Benjamin J Lamont, Sofianos Andrikopoulos

Journal article  |  2014  |  Journal of Endocrinology

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes

CE Hagberg, A Mehlem, A Falkevall, L Muhl, BC Fam, H Ortsäter, P Scotney, D Nyqvist, E Samén, L Lu, S Stone-Elander, J Proietto, S Andrikopoulos, A Sjöholm, A Nash, U Eriksson

Journal article  |  2014  |  Diabetes Technology & Therapeutics

Exercise-induced muscle glucose uptake in mice with graded, muscle-specific GLUT-4 deletion.

Kirsten F Howlett, Sofianos Andrikopoulos, Joseph Proietto, Mark Hargreaves

Journal article  |  2013  |  Physiological Reports

To investigate the importance of the glucose transporter GLUT-4 for muscle glucose uptake during exercise, transgenic mice with sk..

Glucose homeostasis can be differentially modulated by varying individual components of a western diet

Josephine M Forbes, Samantha P Cowan, Sofianos Andrikopoulos, Amy L Morley, Leigh C Ward, Karen Z Walker, Mark E Cooper, Melinda T Coughlan

Journal article  |  2013  |  Journal of Nutritional Biochemistry

A novel mechanism regulating insulin secretion involving Herpud1 in mice

N Wong, G Morahan, M Stathopoulos, J Proietto, S Andrikopoulos

Journal article  |  2013  |  DIABETOLOGIA

Neprilysin Deficiency Protects Against Fat-Induced Insulin Secretory Dysfunction by Maintaining Calcium Influx

Sakeneh Zraika, Duk-Su Koh, Breanne M Barrow, Bao Lu, Steven E Kahn, Sofianos Andrikopoulos

Journal article  |  2013  |  Diabetes

DICARBA MODIFICATION OF INSULIN PROVIDES GREATER GLUCOSE LOWERING EFFECT UNDER NORMAL AND INSULIN RESISTANT STATES, WHILE AVOIDING THE MITOGENIC ACTIVITY OF UNMODIFIED INSULIN

S Andrikopoulos, B van Lierop, BC Fam, B Forbes, A Robinson

Journal article  |  2013  |  DIABETES TECHNOLOGY & THERAPEUTICS

First Phase Insulin Secretion and Type 2 Diabetes

K Cheng, S Andrikopoulos, JE Gunton

Journal article  |  2013  |  Current Molecular Medicine

Response to comment on: Visinoni et al. The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity. Diabetes 2012;61:1122-1132

BC Fam, CN Joannides, S Andrikopoulos

Journal article  |  2012  |  Diabetes

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes

Carolina E Hagberg, Annika Mehlem, Annelie Falkevall, Lars Muhl, Barbara C Fam, Henrik Ortsater, Pierre Scotney, Daniel Nyqvist, Erik Samen, Li Lu, Sharon Stone-Elander, Joseph Proietto, Sofianos Andrikopoulos, Ake Sjoholm, Andrew Nash, Ulf Eriksson

Journal article  |  2012  |  Nature

The liver: Key in regulating appetite and body weight.

Barbara C Fam, Christos N Joannides, Sofianos Andrikopoulos

Journal article  |  2012  |  Adipocyte

Liver fructose-1,6-bisphosphatase (FBPase) is a regulatory enzyme in gluconeogenesis that is elevated by obesity and dietary fat i..

Normal muscle glucose uptake in mice deficient in muscle GLUT4

Barbara C Fam, Laura J Rose, Rebecca Sgambellone, Zheng Ruan, Joseph Proietto, Sofianos Andrikopoulos

Journal article  |  2012  |  Journal of Endocrinology

Methazolamide Is a New Hepatic Insulin Sensitizer That Lowers Blood Glucose In Vivo

Nicky Konstantopoulos, Juan C Molero, Sean L McGee, Briana Spolding, Tim Connor, Melissa de Vries, Stephen Wanyonyi, Richard Fahey, Shona Morrison, Courtney Swinton, Sharon Jones, Adrian Cooper, Lucia Garcia-Guerra, Victoria C Foletta, Guy Krippner, Sofianos Andrikopoulos, Ken R Walder

Journal article  |  2012  |  Diabetes

High Passage MIN6 Cells Have Impaired Insulin Secretion with Impaired Glucose and Lipid Oxidation

Kim Cheng, Viviane Delghingaro-Augusto, Christopher J Nolan, Nigel Turner, Nicole Hallahan, Sofianos Andrikopoulos, Jenny E Gunton

Journal article  |  2012  |  PLoS One

The Role of Liver Fructose-1,6-Bisphosphatase in Regulating Appetite and Adiposity

Sherley Visinoni, Nurul Fathiah Izzati Khalid, Christos N Joannides, Arthur Shulkes, Mildred Yim, Jon Whitehead, Tony Tiganis, Benjamin J Lamont, Jenny M Favaloro, Joseph Proietto, Sofianos Andrikopoulos, Barbara C Fam

Journal article  |  2012  |  DIABETES

Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta

Martha Lappas, Sofianos Andrikopoulos, Michael Permezel

Journal article  |  2012  |  JOURNAL OF ENDOCRINOLOGY

The Nuclear Receptor, Nor-1, Markedly Increases Type II Oxidative Muscle Fibers and Resistance to Fatigue

Michael A Pearen, Natalie A Eriksson, Rebecca L Fitzsimmons, Joel M Goode, Nick Martel, Sofianos Andrikopoulos, George EO Muscat

Journal article  |  2012  |  Molecular Endocrinology

Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta.

M Lappas, S Andrikopoulos, M Permezel

Journal article  |  2012  |  Journal of Endocrinology

First phase insulin secretion and type 2 diabetes

K Cheng, S Andrikopoulos, JE Gunton

Journal article  |  2012  |  Current Molecular Medicine

Response to comment on: Visinoni et al. the role of liver fuctose-1,6-Bisphosphatase in regulating appetite and adiposity. diabetes 2012;61:1122-1132

BC Fam, C JOANNIDES, S Andrikopoulos

Journal article  |  2012  |  Diabetes

Deficiency in Interferon-gamma Results in Reduced Body Weight and Better Glucose Tolerance in Mice

Nicole Wong, Barbara C Fam, Gitta R Cempako, Gregory R Steinberg, Ken Walder, Thomas W Kay, Joseph Proietto, Sofianos Andrikopoulos

Journal article  |  2011  |  Endocrinology

Advanced Glycation End Products Are Direct Modulators of beta-Cell Function

Melinda T Coughlan, Felicia YT Yap, David CK Tong, Sofianos Andrikopoulos, Anna Gasser, Vicki Thallas-Bonke, Diane E Webster, Jun-ichi Miyazaki, Thomas W Kay, Robyn M Slattery, David M Kaye, Brian G Drew, Bronwyn A Kingwell, Spiros Fourlanos, Per-Henrik Groop, Leonard C Harrison, Mikael Knip, Josephine M Forbes

Journal article  |  2011  |  Diabetes

REGULATION OF RENAL RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS (RAGE) VIA PARACRINE ESTROGENS

BE Harcourt, MT Coughlan, S Andrikopoulos, MC Thomas, C Bruce, MA Febbraio, P Nawroth, A Bierhaus, P Kantharidis, ME Cooper, JM Forbes

Conference Proceedings  |  2011  |  NEPHROLOGY

A primary defect in glucose production alone cannot induce glucose intolerance without defects in insulin secretion

Salvatore P Mangiafico, Shueh H Lim, Sandra Neoh, Helene Massinet, Christos N Joannides, Joseph Proietto, Sofianos Andrikopoulos, Barbara C Fam

Journal article  |  2011  |  Journal of Endocrinology

Targeted reduction of advanced glycation improves renal function in obesity

Brooke E Harcourt, Karly C Sourris, Melinda T Coughlan, Karen Z Walker, Sonia L Dougherty, Sofianos Andrikopoulos, Amy L Morley, Vicki Thallas-Bonke, Vibhasha Chand, Sally A Penfold, Maximilian PJ de Courten, Merlin C Thomas, Bronwyn A Kingwell, Angelika Bierhaus, Mark E Cooper, Barbora de Courten, Josephine M Forbes

Journal article  |  2011  |  Kidney International

The New Zealand obese mouse model of obesity insulin resistance and poor breeding performance: evaluation of ovarian structure and function

Simone Radavelli-Bagatini, Amy R Blair, Joseph Proietto, Poli Mara Spritzer, Sofianos Andrikopoulos

Journal article  |  2011  |  Journal of Endocrinology

Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes (vol 54, pg 1032, 2011)

JM Forbes, J Soderlund, FYT Yap, M Knip, S Andrikopoulos, J Ilonen, O Simell, R Veijola, KC Sourris, MT Coughlan, C Forsblom, R Slattery, ST Grey, M Wessman, H Yamamoto, A Bierhaus, ME Cooper, P-H Groop

Journal article  |  2011  |  Diabetologia

Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes

JM Forbes, J Soderlund, FYT Yap, M Knip, S Andrikopoulos, J Ilonen, O Simell, R Veijola, KC Sourris, MT Coughlan, C Forsblom, R Slattery, ST Grey, M Wessman, H Yamamoto, A Bierhaus, ME Cooper, P-H Groop

Journal article  |  2011  |  Diabetologia

Liver-Specific Suppressor of Cytokine Signaling-3 Deletion in Mice Enhances Hepatic Insulin Sensitivity and Lipogenesis Resulting in Fatty Liver and Obesity

Nirupa Sachithanandan, Barbara C Fam, Stacey Fynch, Nicolas Dzamko, Matthew J Watt, Sam Wormald, Jane Honeyman, Sandra Galic, Joseph Proietto, Sofianos Andrikopoulos, Andrea L Hevener, Thomas WH Kay, Gregory R Steinberg

Journal article  |  2010  |  Hepatology

Temporary Solubilization Of Synthetic Peptides By C-Terminal-Linked Poly-Lys Tail: Application To The SPS Of Insulin Glargine

AB Belgi, MAH Hossain, J Wade, G Tregear, S Andrikopoulos

Conference Proceedings  |  2010  |  JOURNAL OF PEPTIDE SCIENCE

Methods for Enhancing Ring Closing Metathesis Yield in Peptides: Synthesis of a Dicarba Human Growth Hormone Fragment

Bianca J van Lierop, Amanda N Whelan, Sofianos Andrikopoulos, Roger J Mulder, W Roy Jackson, Andrea J Robinson

Journal article  |  2010  |  International Journal of Peptide Research and Therapeutics

T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis

Atsushi Fukushima, Kim Loh, Sandra Galic, Barbara Fam, Ben Shields, Florian Wiede, Michel L Tremblay, Matthew J Watt, Sofianos Andrikopoulos, Tony Tiganis

Journal article  |  2010  |  Diabetes

Obesity and Type 2 diabetes: Slow down!-Can metabolic deceleration protect the islet beta cell from excess nutrient-induced damage?

S Andrikopoulos

Journal article  |  2010  |  Molecular and Cellular Endocrinology

Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy

Adeline LY Tan, Karly C Sourris, Brooke E Harcourt, Vicki Thallas-Bonke, Sally Penfold, Sofianos Andrikopoulos, Merlin C Thomas, Richard C O'Brien, Angelika Bierhaus, Mark E Cooper, Josephine M Forbes, Melinda T Coughlan

Journal article  |  2010  |  American Journal of Physiology: Renal Physiology

The Deletion Variant of Nicotinamide Nucleotide Transhydrogenase (Nnt) Does Not Affect Insulin Secretion or Glucose Tolerance

Nicole Wong, Amy R Blair, Grant Morahan, Sofianos Andrikopoulos

Journal article  |  2010  |  Endocrinology

Reactive Oxygen Species Enhance Insulin Sensitivity

Kim Loh, Haiyang Deng, Atsushi Fukushima, Xiaochu Cai, Benoit Boivin, Sandra Galic, Clinton Bruce, Benjamin J Shields, Beata Skiba, Lisa M Ooms, Nigel Stepto, Ben Wu, Christina A Mitchell, Nicholas K Tonks, Matthew J Watt, Mark A Febbraio, Peter J Crack, Sofianos Andrikopoulos, Tony Tiganis

Journal article  |  2009  |  Cell Metabolism

Position statement of the Australian Diabetes Society: individualisation of glycated haemoglobin targets for adults with diabetes mellitus

N Wah Cheung, Jennifer J Conn, Michael C d'Emden, Jenny E Gunton, Alicia J Jenkins, Glynis P Ross, Ashim K Sinha, Sofianos Andrikopoulos, Stephen Colagiuri, Stephen M Twigg

Journal article  |  2009  |  Medical Journal of Australia

Use of a Temporary "Solubilizing" Peptide Tag for the Fmoc Solid-Phase Synthesis of Human Insulin Glargine via Use of Regioselective Disulfide Bond Formation

Mohammed Akhter Hossain, Alessia Belgi, Feng Lin, Suode Zhang, Fazel Shabanpoor, Linda Chan, Chris Belyea, Hue-Trung Truong, Amy R Blair, Sof Andrikopoulos, Geoffrey W Tregear, John D Wade

Journal article  |  2009  |  Bioconjugate Chemistry

Evaluating the glucose tolerance test in mice

Sofianos Andrikopoulos, Amy R Blair, Nadia Deluca, Barbara C Fam, Joseph Proietto

Journal article  |  2008  |  American Journal of Physiology - Endocrinology and Metabolism

Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver

Sherley Visinoni, Barbara C Fam, Amy Blair, Christian Rantzau, Benjamin J Lamont, Russell Bouwman, Matthew J Watt, Joseph Proietto, Jenny M Favaloro, Sofianos Andrikopoulos

Journal article  |  2008  |  American Journal of Physiology - Endocrinology and Metabolism

Insulin may have a role to play in protecting beta cells from deterioration in diabetes. Reply to DelParigi A [letter]

S Andrikopoulos, J Proietto

Journal article  |  2008  |  Diabetologia

Insulin may have a role to play in protecting beta cells from deterioration in diabetes. Reply to Del Parigi A [letter]

S Andrikopoulos, J Proietto

Journal article  |  2008  |  Diabetologia

Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion - A new mechanism for fat-induced impairment of beta-cell function

Melkam Kebede, Jenny Favaloro, Jenny E Gunton, D Ross Laybutt, Margaret Shaw, Nicole Wong, Barbara C Fam, Kathryn Aston-Mourney, Christian Rantzau, Anthony Zulli, Joseph Proietto, Sofianos Andrikopoulos

Journal article  |  2008  |  Diabetes

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

BE Needham, ME Wlodek, GD Ciccotosto, BC Fam, CL Masters, J Proietto, S Andrikopoulos, R Cappai

Journal article  |  2008  |  Journal of Pathology

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

BE Needham, ME Wlodek, GD Ciccotosto, BC Fam, CL Masters, J Proietto, S Andrikopoulos, R Cappai

Journal article  |  2008  |  Journal of Pathology

Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin

K Aston-Mourney, J Proietto, G Morahan, S Andrikopoulos

Journal article  |  2008  |  Diabetologia

Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin

K Aston-Mourney, J Proietto, G Morahan, S Andrikopoulos

Journal article  |  2008  |  Diabetologia

Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion

M KEBEDE, J FAVALORO, JEG GUNTON, DRL LAYBUTT, M SHAW, N WONG, B FAM, K ASTON-MOURNEY, C RANTZAU, A ZULLI, J PROIETTO, S ANDRIKOPOULOS

Journal article  |  2008  |  Diabetes

Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes

K Aston-Mourney, N Wong, M Kebede, S Zraika, L Balmer, JM McMahon, BC Fam, J Favaloro, J Proietto, G Morahan, S Andrikopoulos

Journal article  |  2007  |  Diabetologia

Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes

K Aston-Mourney, N Wong, M Kebede, S Zraika, L Balmer, JM McMahon, BC Fam, J Favaloro, J Proietto, G Morahan, S Andrikopoulos

Journal article  |  2007  |  Diabetologia

Modulation of central leptin sensitivity and energy balance in a rat model of diet-induced obesity

BC Fam, MJ Morris, MJ Hansen, M Kebede, S Andrikopoulos, J Proietto, AW Thorburn

Journal article  |  2007  |  Diabetes, Obesity and Metabolism

Modulation of central leptin sensitivity and energy balance in a rat model of diet-induced obesity

BC Fam, MJ Morris, MJ Hansen, M Kebede, S Andrikopoulos, J Proietto, AW Thorburn

Journal article  |  2007  |  Diabetes Obesity & Metabolism

Transgenic mice overexpressing human fructose-1,6-bisphosphatase in the liver develop glucose intolerance in response to a high fat diet

S Visinoni, BC Fam, A Blair, C Rantzau, BJ Lamont, R Bouwman, J Favaloro, J Proietto, S Andrikopoulos

Conference Proceedings  |  2007  |  DIABETOLOGIA

In vivo quantification of fat content in mice using the Hologic QDR 4500A densitometer

Susan M Senn, Susan Kantor, Brian J Leury, Sofianos Andrikopoulos, Terence J O'Brien, Margaret J Morrisde, Joseph Proiettode, John D Wark

Journal article  |  2007  |  Obesity Research & Clinical Practice

The New Zealand Obese Mouse: Polygenic model of obesity, glucose intolerance, and the metabolic syndrome

BC Fam, S Andrikopoulos

Book Chapter  |  2007

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

Gregory R Steinberg, Belinda J Michell, Bryce JW van Denderen, Matthew J Watt, Andrew L Carey, Barbara C Fam, Sofianos Andrikopoulos, Joseph Proietto, Cem Z Gorgun, David Carling, Gokhan S Hotamisligil, Mark A Febbraio, Thomas W Kay, Bruce E Kemp

Journal article  |  2006  |  Cell Metabolism

Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice

Gregory R Steinberg, Matthew J Watt, Barbara C Fam, Joseph Proietto, Sofianos Andrikopoulos, Andrew M Allen, Mark A Febbraio, Bruce E Kemp

Journal article  |  2006  |  Endocrinology

The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets

S Zraika, K Aston-Mourney, DR Laybutt, M Kebede, ME Dunlop, J Proietto, S Andrikopoulos

Journal article  |  2006  |  Diabetologia

Expression of Human Fructose-1,6-Bisphosphatase in the Liver of Transgenic Mice Results in Increased Glycerol Gluconeogenesis

Benjamin J Lamont, Sherley Visinoni, Barbara C Fam, Melkam Kebede, Blaise Weinrich, Stavroula Papapostolou, Helene Massinet, Joseph Proietto, Jenny Favaloro, Sofianos Andrikopoulos

Journal article  |  2006  |  Endocrinology

The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets

S Zraika, K Aston-Mourney, DR Laybutt, M Kebede, ME Dunlop, J Proietto, S Andrikopoulos

Journal article  |  2006  |  Diabetologia

Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis

Benjamin J Lamont, Sherley Visinoni, Barbara C Fam, Melkam Kebede, Blaise Weinrich, Stavroula Papapostolou, Helene Massinet, Joseph Proietto, Jenny Favaloro, Sofianos Andrikopoulos

Journal article  |  2006  |  Endocrinology

Amylin in the periphery II: An updated mini-review

Peter J Wookey, Thomas A Lutz, Sof Andrikopoulos

Journal article  |  2006  |  Scientific World Journal

A mouse model - Differential effect of genetic background oil valproate-induced bone loss

S Senn, S Kantor, S Andrikopoulos, TJ O'Brien, MJ Morris, JD Wark

Conference Proceedings  |  2005  |  JOURNAL OF THE NEUROLOGICAL SCIENCES

Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet

S Andrikopoulos, CM Massa, K Aston-Mourney, A Funkat, BC Fam, RL Hull, SE Kahn, J Proietto

Journal article  |  2005  |  Journal of Endocrinology

Investigational agents that protect pancreatic islet beta-cells from failure

K Aston-Mourney, J Proietto, S Andrikopoulos

Journal article  |  2005  |  Expert Opinion on Investigational Drugs

Socs1 deficiency enhances hepatic insulin signaling

E Jamieson, MMW Chong, GR Steinberg, V Jovanovska, BC Fam, DVR Bullen, Y Chen, BE Kemp, J Proietto, TWH Kay, S Andrikopoulos

Journal article  |  2005  |  Journal of Biological Chemistry

High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction

S Kooptiwut, M Kebede, S Zraika, S Visinoni, K Aston-Mourney, J Favaloro, C Tikellis, MC Thomas, JM Forbes, ME Cooper, M Dunlop, J Proietto, S Andrikopoulos

Journal article  |  2005  |  Journal of Molecular Endocrinology

Valproate has strain-specific effects on bone mineral content in mice

S Senn, S Kantor, S Andrikopoulos, TJ O'Brien, MJ Morris, JD Wark

Conference Proceedings  |  2005  |  BONE

Valproate has strain-specific effects on bone mineral content in mice

S Senn, S Kantor, S Andrikopoulos, TJ O'Brien, MJ Morris, JD Wark

Conference Proceedings  |  2005  |  BONE

Metabolic adaptations of three inbred strains of mice (C57BL6, DBA/2, and 129T2) in response to a high-fat diet

A Funkat, CM Massa, V Jovanovska, J Proietto, S Andrikopoulos

Journal article  |  2004  |  Journal of Nutrition

Molecular mechanisms of increased glucose production: Identifying potential therapeutic targets

J Proietto, S Andrikopoulos

Journal article  |  2004  |  Journal of Investigative Medicine

Erratum: Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide. (American Journal of Physiology - Endocrinology and Metabolism (March 2004) 286 (E418-E424))

S Andrikopoulos, RL Hull, B Verchere, F Wang, SM Wilbur, TN Wight, L Marzban, SE Kahn

Journal article  |  2004  |  American Journal of Physiology-Endocrinology and Metabolism

Elevated SNAP-25 is associated with fatty acid-induced impairment of mouse islet function

S Zraika, ME Dunlop, J Proietto, S Andrikopoulos

Journal article  |  2004  |  Biochemical and Biophysical Research Communications

Improved islet morphology after blockade of the renin-angiotensin system in the ZDF rat

C Tikellis, PJ Wookey, R Candido, S Andrikopoulos, MC Thomas, ME Cooper

Journal article  |  2004  |  Diabetes

Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide

S Andrikopoulos, RL Hull, CB Verchere, F Wang, SM Wilbur, TN Wight, L Marzban, SE Kahn

Journal article  |  2004  |  American Journal of Physiology - Endocrinology and Metabolism

Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide

S Andrikopoulos, RL Hull, CB Verchere, F Wang, SM Wilbur, TN Wight, L Marzban, SE Kahn

Journal article  |  2004  |  American Journal of Physiology - Endocrinology and Metabolism

Molecular mechanisms of increased glucose production: Identifying potential therapeutic targets

J Proietto, S Andrikopoulos

Conference Proceedings  |  2004  |  Journal of Investigative Medicine

Many patients with type 2 diabetes go on to require insulin therapy to achieve adequate control. A need remains to develop new cla..

Threshold effects of glucose transporter-4 (GLUT4) deficiency on cardiac glucose uptake and development of hypertrophy

SJ Kaczmarczyk, S Andrikopoulos, J Favaloro, AA Domenighetti, A Dunn, M Ernst, D Grail, M Fodero-Tavoletti, CE Huggins, LM Delbridge, JD Zajac, J Proietto

Journal article  |  2003  |  Journal of Molecular Endocrinology

Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney

BJ Lamont, S Andrikopoulos, A Funkat, J Favaloro, JM Ye, EW Kraegen, KF Howlett, JD Zajac, J Proietto

Journal article  |  2003  |  Diabetologia

Metabolic adaptations of three inbred strains of mice (C57BL/6, DBA/2 AND 129Sv) in response to a high fat diet

A Funkat, V Jovanovska, J Proietto, S Andrikopoulos

Conference Proceedings  |  2003  |  DIABETOLOGIA

Proteoglycans synthesized and secreted by pancreatic islet beta-cells bind amylin.

Susan Potter-Perigo, Rebecca L Hull, Christina Tsoi, Kathleen R Braun, Sofianos Andrikopoulos, Jeanette Teague, C Bruce Verchere, Steven E Kahn, Thomas N Wight

Journal article  |  2003  |  Archives of Biochemistry and Biophysics

Pancreatic islet amyloid deposits in type 2 diabetes are associated with decreased islet beta-cell function. They contain both amy..

Interleukin-6 gene expression is increased in insulin-resistant rat skeletal muscle following insulin stimulation

AL Carey, B Lamont, S Andrikopoulos, I Koukoulas, J Proietto, MA Febbraio

Journal article  |  2003  |  Biochemical and Biophysical Research Communications

Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid.

Rebecca L Hull, Sofianos Andrikopoulos, C Bruce Verchere, Josep Vidal, Feng Wang, Miriam Cnop, Ronald L Prigeon, Steven E Kahn

Journal article  |  2003  |  Diabetes

Transgenic mice expressing the amyloidogenic human islet amyloid polypeptide (hIAPP) in their islet beta-cells are a model of isle..

The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice.

J Vidal, C Bruce Verchere, S Andrikopoulos, F Wang, RL Hull, M Cnop, KL Olin, RC LeBoeuf, KD O'Brien, A Chait, SE Kahn

Journal article  |  2003  |  Diabetologia

AIMS/HYPOTHESIS: Islet amyloid deposits are present in over 85% of Type 2 diabetic patients and have been suggested to be pathogen..

The hexosamine biosynthesis pathway regulates insulin secretion via protein glycosylation in mouse islets

S Zraika, M Dunlop, J Proietto, S Andrikopoulos

Journal article  |  2002  |  Archives of Biochemistry and Biophysics

Threshold effects of GLUT4 deficiency on glucose uptake and cardiac morphology

J Proietto, S Kaczmarczyk, S Andrikopoulos, J Favaloro, A Dunn, M Fodero, L Delbridge, J Zajac

Conference Proceedings  |  2002  |  DIABETOLOGIA

Comparison of Insulin Secretory Function in Two Mouse Models with Different Susceptibility to β-Cell Failure.

Suwattanee Kooptiwut, Sakeneh Zraika, Anne W Thorburn, Marjorie E Dunlop, Rima Darwiche, Thomas W Kay, Joseph Proietto, Sofianos Andrikopoulos

Journal article  |  2002  |  Endocrinology

Comparison of insulin secretory function in two mouse models with different susceptibility to beta-cell failure

S Kooptiwut, S Zraika, AW Thorburn, ME Dunlop, R Darwiche, TW Kay, J Proietto, S Andrikopoulos

Journal article  |  2002  |  Endocrinology

Effects of free fatty acids on insulin secretion in obesity.

S Zraika, M Dunlop, J Proietto, S Andrikopoulos

Journal article  |  2002  |  Obesity Reviews

The prevalence of obesity in Western society has reached epidemic proportions and its aetiological role in the development of type..

Interleukin-6 expression in insulin-resistant rodent skeletal muscle

MA Febbraio, AL Carey, B Lamont, P Koukoulas, S Andrikopoulos, J Proietto

Conference Proceedings  |  2002  |  JOURNAL OF PHYSIOLOGY-LONDON

Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin

SM Song, S Andrikopoulos, C Filippis, AW Thorburn, D Khan, J Proietto

Journal article  |  2001  |  American Journal of Physiology - Endocrinology and Metabolism

Oophorectomy promotes islet amyloid formation in human islet amyloid polypeptide transgenic mice.

RL Hull, CB Verchere, S Andrikopoulos, F Wang, J Vidal, SE Kahn

Conference Proceedings  |  2001  |  Diabetes

The New Zealand obese mouse: A polygenic model of type 2 diabetes

S ANDRIKOPOULOS, A THORBURN, J PROIETTO

Book Chapter  |  2001

beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

S Andrikopoulos, CB Verchere, Y Terauchi, T Kadowaki, SE Kahn

Journal article  |  2000  |  Diabetes

Type 2 diabetes is characterized by impaired beta-cell function, hyperglycemia, and islet amyloid deposition. The primary constitu..

Oophorectomy promotes islet amyloid formation in a transgenic mouse model of Type II diabetes.

SE Kahn, S Andrikopoulos, CB Verchere, F Wang, RL Hull, J Vidal

Journal article  |  2000  |  Diabetologia

AIMS/HYPOTHESIS: In Type II (non-insulin-dependent) diabetes mellitus, amyloid depletes islet mass. We previously found that 81% o..

Erratum: Two novel immortal pancreatic β-cell lines expressing and secreting human islet amyloid polypeptide do not spontaneously develop islet amyloid (Diabetes (1999) 48 (1962-1970))

S Andrikopoulos, CB Verchere, JC Teague, WM Howell, WY Fujimoto, TN Wight, SE Kahn

Journal article  |  2000  |  Diabetes

Two novel immortal pancreatic beta-cell lines expressing and secreting human islet amyloid polypeptide do not spontaneously develop islet amyloid.

S Andrikopoulos, CB Verchere, JC Teague, WM Howell, WY Fujimoto, TN Wight, SE Kahn

Journal article  |  1999  |  Diabetes

Type 2 diabetes is characterized by islet amyloid deposits, which are primarily composed of the amyloidogenic human form of islet ..

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.

SE Kahn, S Andrikopoulos, CB Verchere

Journal article  |  1999  |  Diabetes

Islet amyloid has been recognized as a pathological entity in type 2 diabetes since the turn of the century. It has as its unique ..

Human aging is associated with parallel reductions in insulin and amylin release.

CJ Dechenes, CB Verchere, S Andrikopoulos, SE Kahn

Journal article  |  1998  |  American Journal of Physiology-Endocrinology and Metabolism

Aging is associated with an increased risk of type 2 diabetes. To determine whether the insulin resistance of aging is associated ..

Reduced amylin release is a characteristic of impaired glucose tolerance and type 2 diabetes in Japanese Americans.

SE Kahn, CB Verchere, S Andrikopoulos, PJ Asberry, DL Leonetti, PW Wahl, EJ Boyko, RS Schwartz, L Newell-Morris, WY Fujimoto

Journal article  |  1998  |  Diabetes

Islet amyloid is a characteristic feature of type 2 diabetes. Its major component is the normal beta-cell secretory product amylin..

Transgenic overproduction of islet amyloid polypeptide (amylin) is not sufficient for islet amyloid formation.

CB Verchere, DA D'Alessio, S Wang, S Andrikopoulos, SE Kahn

Conference Proceedings  |  1997  |  Hormone and Metabolic Research

Islet amyloid polypeptide forms islet amyloid deposits in non-insulin-dependent diabetes mellitus. We have generated transgenic mi..

Impaired regulation of hepatic fructose-1,6-biphosphatase in the New Zealand Obese mouse: an acquired defect.

S Andrikopoulos, G Rosella, SJ Kaczmarczyk, JD Zajac, J Proietto

Journal article  |  1996  |  Metabolism

Increased hepatic glucose production, a feature of (non-insulin-dependent diabetes mellitus [NIDDM]), is present at an early age i..

Understanding the pathogenesis of type 2 diabetes: can we get off the metabolic merry-go-rounds?

J Proietto, S Andrikopoulos, G Rosella, A Thorburn

Journal article  |  1995  |  Australian and New Zealand Journal of Medicine

The aetiology of non-insulin-dependent diabetes mellitus (NIDDM) is not known. The concordance of NIDDM in identical twins and dif..

The biochemical basis of increased hepatic glucose production in a mouse model of type 2 (non-insulin-dependent) diabetes mellitus.

S Andrikopoulos, J Proietto

Journal article  |  1995  |  Diabetologia

The mechanism of increased hepatic glucose production in obese non-insulin-dependent diabetic (NIDDM) patients is unknown. The New..

Defects in liver and muscle glycogen metabolism in neonatal and adult New Zealand obese mice.

A Thorburn, S Andrikopoulos, J Proietto

Journal article  |  1995  |  Metabolism

Impaired glycogen synthesis is present in subjects at risk for developing non-insulin-dependent diabetes mellitus (NIDDM), suggest..

Impaired glucose tolerance and increased weight gain in transgenic rats overexpressing a non-insulin-responsive phosphoenolpyruvate carboxykinase gene.

G Rosella, JD Zajac, L Baker, SJ Kaczmarczyk, S Andrikopoulos, TE Adams, J Proietto

Journal article  |  1995  |  Molecular Endocrinology

The effects of an overexpressed, non-insulin-responsive gluconeogenic enzyme, phosphoenolpyruvate carboxykinase (GTP) (PEPCK; EC 4..

Impaired regulation of hepatic fructose-1,6-bisphosphatase in the New Zealand obese mouse model of NIDDM.

S Andrikopoulos, G Rosella, E Gaskin, A Thorburn, S Kaczmarczyk, JD Zajac, J Proietto

Journal article  |  1993  |  Diabetes

The New Zealand obese mouse, a model of NIDDM, is characterized by hyperglycemia, hyperinsulinemia, and hepatic and peripheral ins..

Impaired suppression of gluconeogenesis induced by overexpression of a noninsulin-responsive phosphoenolpyruvate carboxykinase gene.

G Rosella, JD Zajac, SJ Kaczmarczyk, S Andrikopoulos, J Proietto

Journal article  |  1993  |  Molecular Endocrinology

Despite detailed knowledge of the regulation of individual steps in the gluconeogenic pathway, the relative importance of each ste..