Peter Hamblin

Sodium-glucose cotransporter type 2 inhibitors: managing the small but critical risk of diabetic ketoacidosis

Peter S Hamblin, Rosemary Wong, Leon A Bach

Journal article  |  2020  |  Medical Journal of Australia

A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH oxidase with the first-in-class Nox-1/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excretion: Protocol and statistical considerations

Anne T Reutens, Karin Jandeleit-Dahm, Merlin Thomas, Agus Salim, Alysha M De Livera, Leon A Bach, Peter G Colman, Timothy ME Davis, Elif Ekinci, Greg Fulcher, Peter Shane Hamblin, Mark A Kotowicz, Richard J MacIsaac, Claire Morbey, David Simmons, Georgia Soldatos, Gary Wittert, Ted Wu, Mark E Cooper, Jonathan E Shaw

Journal article  |  2020  |  Contemporary Clinical Trials

PURPOSE: Kidney disease caused by type 1 diabetes can progress to end stage renal disease and can increase mortality risk. Nicotin..

Lead poisoning associated with illicit opium use

Joshua Wong, Elyssia Bourke, Vanessa Roberts, Seok M Lim, Douglas Johnson, Peter S Hamblin, Harin Karunajeewa, Shaun Greene

Journal article  |  2020  |  Internal Medicine Journal

Lead poisoning is an uncommon and challenging diagnosis to make. In 2018, The Victorian Department of Health issued a health warni..

Subclinical hypothyroidism during pregnancy: the Melbourne public hospitals consensus

Peter S Hamblin, Penelope M Sheehan, Carolyn Allan, Christine A Houlihan, Zhong X Lu, Simon P Forehan, Duncan J Topliss, Christopher Gilfillan, Bala Krishnamurthy, Debra Renouf, Shoshana Sztal-Mazer, Suresh Varadarajan

Journal article  |  2019  |  Internal Medicine Journal

BACKGROUND: Interest in potential adverse outcomes associated with maternal subclinical hypothyroidism (normal Free T4, elevated T..

SGLT2 Inhibitors Increase the Risk of Diabetic Ketoacidosis Developing in the Community and During Hospital Admission

Peter S Hamblin, Rosemary Wong, Elif Ekinci, Spiros Fourlanos, Sonali Shah, Alicia R Jones, Matthew JL Hare, Genevieve L Calder, Dilan Seneviratne Epa, Elizabeth M George, Rinky Giri, Mark A Kotowicz, Mervyn Kyi, Nicole Lafontaine, Richard J MacIsaac, Brendan J Nolan, David N O'Neal, Debra Renouf, Suresh Varadarajan, Jennifer Wong, et al.

Journal article  |  2019  |  The Journal of Clinical Endocrinology & Metabolism

CONTEXT: Diabetic ketoacidosis (DKA) has been associated with the use of sodium glucose cotransporter 2 inhibitors (SGLT2is). OBJE..

DETECTION AND MANAGEMENT OF CHRONIC KIDNEY DISEASE AND DIABETES WITH E-TECHNOLOGY BASED INTERVENTION: ANALYSIS OF THE CHRONIC DISEASE EARLY DETECTION AND IMPROVED MANAGEMENT IN PRIMARY CARE PROJECT (CD IMPACT)

Julia Jones, Natalie Lumsden, Koen Simons, Sanduni Fernando, Christopher Neil, Jo-Anne Manski-Nankervis, Peter Hamblin, Edward Janus, Craig Nelson

Conference Proceedings  |  2019  |  NEPHROLOGY DIALYSIS TRANSPLANTATION

Hypothyroidism associated with therapy for multi-drug-resistant tuberculosis in Australia

Yee-Ming M Cheung, Karen Van, Lan Lan, Rahul Barmanray, Sarah Y Qian, William Y Shi, Jennifer LA Wong, Peter S Hamblin, Peter G Colman, Duncan J Topliss, Justin T Denholm, Mathis Grossmann

Journal article  |  2019  |  Internal Medicine Journal

Aspirin for primary cardiovascular disease prevention: time to re-evaluate guidelines?

Rahul Barmanray, Peter S Hamblin

Journal article  |  2019  |  Internal Medicine Journal

Quantifying the hidden healthcare cost of diabetes mellitus in Australian hospital patients

Amalia Karahalios, Gowri Somarajah, Peter S Hamblin, Harin Karunajeewa, Edward D Janus

Journal article  |  2018  |  Internal Medicine Journal

Difficulties in cerebrospinal fluid beta hCG interpretation in a patient with an infundibular lesion

Alicia R Jones, Alan McNeil, Christopher Yates, Bala Krishnamurthy, Peter S Hamblin

Journal article  |  2018  |  Endocrinology, Diabetes & Metabolism Case Reports

Reversal of end-stage heart failure in juvenile hemochromatosis with iron chelation therapy: a case report.

Shamil D Cooray, Neel M Heerasing, Laura A Selkrig, V Nathan Subramaniam, P Shane Hamblin, Cameron J McDonald, Catriona A McLean, Elissa McNamara, Angeline S Leet, Stuart K Roberts

Journal article  |  2018  |  Journal of Medical Case Reports

BACKGROUND: Juvenile hemochromatosis is the most severe form of iron overloading phenotype. Although rare, it should be suspected ..

Localisation of occult extra-pancreatic insulinoma using glucagon-like peptide-1 receptor molecular imaging

Anna K Mossman, David A Pattison, Rodney J Hicks, Peter S Hamblin, Christopher J Yates

Journal article  |  2018  |  Internal Medicine Journal

Pooled genome wide association detects association upstream of FCRL3 with Graves' disease

Jwu Jin Khong, Kathryn P Burdon, Yi Lu, Kate Laurie, Lefta Leonardos, Paul N Baird, Srujana Sahebjada, John P Walsh, Adam Gajdatsy, Peter R Ebeling, Peter Shane Hamblin, Rosemary Wong, Simon P Forehan, Spiros Fourlanos, Anthony P Roberts, Matthew Doogue, Dinesh Selva, Grant W Montgomery, Stuart Macgregor, Jamie E Craig

Journal article  |  2016  |  BMC Genomics

The characteristics of wound pain associated with diabetes-related foot ulcers: a pilot study

AM Dickinson, N Frescos, JC Firth, PS Hamblin

Journal article  |  2016  |  WOUND PRACTICE AND RESEARCH

Persistent syndrome of inappropriate antidiuretic hormone secretion following traumatic brain injury

Michael Dick, Sarah R Catford, Kavita Kumareswaran, Peter Shane Hamblin, Duncan J Topliss

Journal article  |  2015  |  Endocrinology, Diabetes & Metabolism Case Reports

The true prevalence of diabetes in hospital patients and its implications

G Somarajah, H Karunajeewa, PS Hamblin, E Karahalios, E Janus

Journal article  |  2015  |  Internal Medicine Journal

The high burden of inpatient diabetes mellitus: the Melbourne Public Hospitals Diabetes Inpatient Audit

Leon A Bach, Elif I Ekinci, Dennis Engler, Chris Gilfillan, P Shane Hamblin, Richard J MacIssac, Georgia Soldatos, Cheryl Steele, Glenn M Ward, Sue Wyatt

Journal article  |  2014  |  Medical Journal of Australia

An Algorithm Guiding Patient Responses to Real-Time-Continuous Glucose Monitoring Improves Quality of Life

Alicia J Jenkins, Balasubramanian Krishnamurthy, James D Best, Fergus J Cameron, Peter G Colman, Peter S Hamblin, Michele A O'Connell, Christine Rodda, Helena Teede, David N O'Neal

Journal article  |  2011  |  Diabetes Technology & Therapeutics

An elusive phaeochromocytoma

Christopher J Yates, Sybil A McAuley, Simon Grodski, Peter Shane Hamblin, Peter R Ebeling

Journal article  |  2011  |  Medical Journal of Australia

Evaluation of an algorithm to guide patients with type 1 diabetes treated with continuous subcutaneous insulin infusion on how to respond to real-time continuous glucose levels: A randomized controlled trial (Diabetes Care (2010) 33, (1242-1248))

AJ Jenkins, B Krishnamurthy, JD Best, FJ Cameron, PG Colman, S Farish, PS Hamblin, MA O'Connell, C Rodda, K Rowley, H Teede, DN O'Neal

Journal article  |  2010  |  Diabetes Care

Evaluation of an Algorithm to Guide Patients With Type 1 Diabetes Treated With Continuous Subcutaneous Insulin Infusion on How to Respond to Real-Time Continuous Glucose Levels A randomized controlled trial

Alicia J Jenkins, Balasubramanium Krishnamurthy, James D Best, Fergus Cameron, Peter G Colman, Steven Farish, Peter S Hamblin, Michele A O'Connell, Christine Rodda, Kevin Rowley, Helena Teede, David N O'Neal

Journal article  |  2010  |  Diabetes Care

Patients presenting with severe hypotonic hyponatremia: etiological factors, assessment, and outcomes.

Thuy Vu, Rosemary Wong, P Shane Hamblin, Jeffrey Zajac, Mathis Grossmann

Journal article  |  2009  |  Hospital Practice

BACKGROUND: Although hospital-acquired hyponatremia is well described, severe community-acquired hyponatremia has been studied les..

Recombinant human thyroid-stimulating hormone (Thyrogen) in thyroid cancer follow up: experience at a single institution.

R Wong, DJ Topliss, LA Bach, PS Hamblin, V Kalff, F Long, JR Stockigt

Journal article  |  2009  |  Internal Medicine Journal

BACKGROUND: Recombinant human thyroid-stimulating hormone (Thyrogen; Genzyme Corporation, Cambridge, MA, USA) (rhTSH)-stimulated s..

Gonadotroph adenoma in multiple endocrine neoplasia type 1.

Shoshana Sztal-Mazer, Duncan J Topliss, Richard W Simpson, P Shane Hamblin, Jeffrey V Rosenfeld, Catriona A McLean

Journal article  |  2008  |  Endocrine Practice

OBJECTIVE: To describe a case of an in vivo follicle-stimulating hormone (FSH)-secreting gonadotroph adenoma in a man with multipl..

Life-threatening milk-alkali syndrome resulting from antacid ingestion during pregnancy.

Huy A Tran

Journal article  |  2005  |  Medical Journal of Australia

Life-threatening milk-alkali syndrome resulting from antacid ingestion during pregnancy.

Michelle V Gordon, Lawrence P McMahon, P Shane Hamblin

Journal article  |  2005  |  Medical Journal of Australia

Selective versus universal screening for gestational diabetes mellitus: an evaluation of predictive risk factors

RX Davey, PS Hamblin

Journal article  |  2001  |  Medical Journal of Australia

Diabetic emergencies

PS Hamblin

Journal article  |  1996  |  Current Therapeutics

Effects of thyroid hormone on sex hormone-binding globulin gene expression in human cells.

LE Raggatt, RB Blok, PS Hamblin, JW Barlow

Journal article  |  1992  |  The Journal of Clinical Endocrinology & Metabolism

We have used a human hepatoblastoma cell line to establish a model system for thyroid hormone (T3) action in human cells. HepG2 ce..

PRACTICAL MANAGEMENT OF DIABETIC-KETOACIDOSIS AND HYPEROSMOLAR COMA

PS HAMBLIN, DJ TOPLISS, JR STOCKIGT

Journal article  |  1990  |  Australian and New Zealand Journal of Medicine

In diabetic ketoacidosis (DKA) and particularly in hyperosmolar coma, rapid normalisation of the measured extracellular fluid abno..

Interaction between fructose and glucose on the regulation of the nuclear precursor for mRNA-S14.

PS Hamblin, Y Ozawa, A Jefferds, CN Mariash

Journal article  |  1989  |  Journal of Biological Chemistry

We have examined the mechanism of the carbohydrate induction of rat hepatic mRNA-S14 to the intragastric administration of sucrose..

DEATHS ASSOCIATED WITH DIABETIC-KETOACIDOSIS AND HYPEROSMOLAR COMA, 1973-1988

PS HAMBLIN, DJ TOPLISS, N CHOSICH, DW LORDING, JR STOCKIGT

Journal article  |  1989  |  Medical Journal of Australia

We assessed the possibility of improvements in the management of the potentially fatal acute hyperglycaemic complications of diabe..

Triiodothyronine rapidly reverses inhibition of S14 gene transcription by glucagon.

WB Kinlaw, HL Schwartz, PS Hamblin, CN Mariash, JH Oppenheimer

Journal article  |  1988  |  Endocrinology

The rapid response of hepatic mRNA-S14 to T3 has made this sequence an important model for studying the mechanism of hormonal indu..

Furosemide, fenclofenac, diclofenac, mefenamic acid and meclofenamic acid inhibit specific T3 binding in isolated rat hepatic nuclei.

DJ Topliss, PS Hamblin, E Kolliniatis, CF Lim, JR Stockigt

Journal article  |  1988  |  Journal of Endocrinological Investigation

Previous studies with phenytoin (DPH) show that this inhibitor of thyroid hormone binding to plasma proteins also interacts with s..

Triiodothyronine regulation of multiple rat hepatic genes: requirement for ongoing protein synthesis.

PS Hamblin, A Santos, NC Wong, HL Schwartz, JH Oppenheimer

Journal article  |  1987  |  Molecular Endocrinology

We have examined the role of rapidly turning over proteins in the T3 regulation of multiple rat hepatic genes. T3 induction of the..

EFFECT OF ORAL FRUSEMIDE ON DIAGNOSTIC INDEXES OF THYROID-FUNCTION

HH NEWNHAM, PS HAMBLIN, F LONG, CF LIM, DJ TOPLISS, JR STOCKIGT

Journal article  |  1987  |  Clinical Endocrinology

We studied the acute effect of standard therapeutic doses of oral frusemide on indices of thyroid function in 34 hospital in-patie..

Relationship between thyrotropin and thyroxine changes during recovery from severe hypothyroxinemia of critical illness.

PS Hamblin, SA Dyer, VS Mohr, BA Le Grand, CF Lim, DV Tuxen, DJ Topliss, JR Stockigt

Journal article  |  1986  |  The Journal of Clinical Endocrinology & Metabolism

In a prospective study of critically ill hypothyroxinemic we assessed the relationship between serum TSH and T4 during the return ..

Iopanoic acid is of minimal benefit in the treatment of severe hyperthyroidism: conclusions from a case study.

PS Hamblin, VS Mohr, JR Stockigt, DJ Topliss

Journal article  |  1985  |  Clinical Endocrinology

Iopanoic acid (1 g/d) was used together with propylthiouracil (1200 mg/d) in the treatment of a patient with very severe hyperthyr..

INTERACTION OF FUROSEMIDE WITH SERUM THYROXINE-BINDING SITES - INVIVO AND INVITRO STUDIES AND COMPARISON WITH OTHER INHIBITORS

JR STOCKIGT, CF LIM, JW BARLOW, KN WYNNE, VS MOHR, DJ TOPLISS, PS HAMBLIN, J SABTO

Journal article  |  1985  |  The Journal of Clinical Endocrinology & Metabolism

The diuretic furosemide inhibits serum protein binding of T4 in equilibrium dialysis, dextran-charcoal, and competitive ligand bin..