Prof Joel Bornstein

Find out more about Joel Bornstein's experience

Joel Bornstein's highlights

FEATURED Journal article

Antibiotic exposure postweaning disrupts the neurochemistry and function of enteric neurons mediating colonic motor activity.

Joel Bornstein's selected work

Role Of The Enteric Nervous System In Antibiotic Associated Diarrhoea

Research Grant

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for ..

Journal article

Analysing Enteric Neuronal Activity In Order To Identify Treatments For Gastrointestinal I..

Internal Research Grant

Colonic dilation and altered ex vivo gastrointestinal motility in the neuroligin-3 knockou..

Journal article

Anatomical-Functional Mapping Of Enteric Neural Circuits

Research Grant

Apurinic/apyrimidinic endonuclease 1/redox factor-1 as a novel therapeutic target for infl..

Projects

Displaying the 18 most recent projects by Joel Bornstein.

Role Of The Enteric Nervous System In Antibiotic Associated Diarrhoea

This project will identify the role played by the gut's own nervous system in the diarrhoea that is often associated with antibiotic treatme..

2019 - 2021

Active

Analysing Enteric Neuronal Activity In Order To Identify Treatments For Gastrointestinal Issues In Autism

2016 - 2017

Completed

Anatomical-Functional Mapping Of Enteric Neural Circuits

2016 - 2019

Completed

Role Of Microbiota In The Developing Enteric Nervous System

The correct development of neurons in the gut is vital for digestive functions. This project will provide novel insights into how environmen..

2016 - 2019

Completed

Cell Therapy For Enteric Neuropathies - The Essential Next Steps

Gastrointestinal motility disorders caused by damage or diseased neurons in the gut wall ("enteric neuropathies) are some of the most clinic..

2015 - 2018

Completed

Wiring The Gut'S Nervous System: Formation And Maturation Of Synapses

This project aims to determine how nerve circuits controlling intestinal functions develop; specifically how communication between specific ..

2013 - 2016

Completed

Effects Of Cholera Toxin On The Gut'S Nervous System

Many bacteria that cause diarrhoea act via the gut’s own nervous system to massively increase the transport of water and salt into the lumen..

2011 - 2014

Completed

How Nutrients And Other Gut Contents Produce The Gut Movements Essential To The Digestion Of Food And Excretion Of Waste

This project will identify the mechanisms that control the mixing of food with digestive juices, the absoprtion of nutrients from the gut to..

2009 - 2013

Completed

Electrical Activity In Early Enteric Neuron Development

Intestinal movements and secretion are critical to the good health and nutrition of both humans and animals. These functions are regulated b..

2008 - 2010

Completed

Mechanisms That Propel Gut Contents Prior To The Development Of Adult Systems

A significant complication of premature births is that the mechanisms that regulate normal intestinal movements have not yet fully developed..

2007 - 2009

Completed

Neural Mechanisms Mediating Hypersecretion And Motility Patterns Induced By Enterotoxins

This project aims to identify the nerve cells that are responsible for the massive oversecretion of water and salt seen with cholera and oth..

2003 - 2005

Completed

Mechanisms Regulating Nutrient Induced Motor Patterns In The Isolated Small Intestine

The movements of the small intestine are essential for the digestion and absorption of a meal and consist of two basic patterns during a 3-4..

Neural Coordination Of Intestinal Motility And Mucosal Secretion Of Water And Salt - Role In Toxin Induced Diarrhoea

This project deals with some of the basic mechanisms underlying disorders of gastrointestinal function and in particular with the mechanisms..

18

Projects

Project Types

Research Grant

Internal Research Grant

Research Contracts

Scholarly Works

Displaying the 288 most recent scholarly works by Joel Bornstein.

Antibiotic exposure postweaning disrupts the neurochemistry and function of enteric neurons mediating colonic motor activity.

Lin Y Hung, Pavitha Parathan, Prapaporn Boonma, Qinglong Wu, Yi Wang, Anthony Haag, Ruth Ann Luna, Joel C Bornstein, Tor C Savidge, Jaime PP Foong

Journal article | 2020 | American Journal of Physiology-Gastrointestinal and Liver Physiology

The period during and immediately after weaning is an important developmental window when marked shifts in gut microbiota can regu..

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders

Madushani Herath, Suzanne Hosie, Joel C Bornstein, Ashley E Franks, Elisa L Hill-Yardin

Journal article | 2020 | Frontiers in Cellular and Infection Microbiology

Colonic dilation and altered ex vivo gastrointestinal motility in the neuroligin-3 knockout mouse

Anita JL Leembruggen, Gayathri K Balasuriya, Jinghong Zhang, Shana Schokman, Kristy Swiderski, Joel C Bornstein, Jess Nithianantharajah, Elisa L Hill-Yardin

Journal article | 2020 | AUTISM RESEARCH

Gastrointestinal (GI) dysfunction is commonly reported by people diagnosed with autism spectrum disorder (ASD; autism) but the cau..

Apurinic/apyrimidinic endonuclease 1/redox factor-1 as a novel therapeutic target for inflammatory bowel disease

Lauren Sahakian, Rhiannon Filippone, Xu Yan, Raquel Abalo, Rajaraman Eri, Joel Bornstein, Mark Kelley, Kulmira Nurgali

Conference Proceedings | 2020 | NEUROGASTROENTEROLOGY AND MOTILITY

Chemotherapy-induced enteric neuropathy and gastrointestinal dysfunction: Mechanisms and novel treatments

Rachel M McQuade, Vanesa Stojanovska, Rhiannon Filippone, Lauren Shakian, Nyanbol Kuol, Majid Hassanzadeganroudsari, Joel C Bornstein, Mark R Kelley, Kulmira Nurgali

Conference Proceedings | 2020 | NEUROGASTROENTEROLOGY AND MOTILITY

The enteric nervous system undergoes significant chemical and synaptic maturation during adolescence in mice

Pavitha Parathan, Yi Wang, Anita JL Leembruggen, Joel C Bornstein, Jaime PP Foong

Journal article | 2020 | Developmental Biology

Adolescence is a critical period of development. It is very likely that there is significant maturation of the enteric nervous sys..

Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in mdx Dystrophic Mice Ameliorated by Oral L-arginine Supplementation

Kristy Swiderski, Rebecka Bindon, Jennifer Trieu, Timur Naim, Shana Schokman, Mathusi Swaminathan, Anita JL Leembruggen, Elisa L Hill-Yardin, Rene Koopman, Joel C Bornstein, Gordon S Lynch

Journal article | 2020 | Journal of Neurogastroenterology and Motility

Background/Aims: Patients with Duchenne muscular dystrophy exhibit significant, ongoing impairments in gastrointestinal (GI) funct..

alpha-Synuclein Regulates Development and Function of Cholinergic Enteric Neurons in the Mouse Colon

M Swaminathan, C Fung, D Finkelstein, JC Bornstein, JPP Foong

Journal article | 2019 | Neuroscience

Alpha-Synuclein (α-Syn) is expressed in the central nervous system and the nervous system of the gut (enteric nervous system, ENS)..

Luminal 5-HT4 receptors-A successful target for prokinetic actions

Rachel M Gwynne, Joel C Bornstein

Journal article | 2019 | Neurogastroenterology & Motility

Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3

Suzanne Hosie, Melina Ellis, Mathusi Swaminathan, Fatima Ramalhosa, Gracia O Seger, Gayathri K Balasuriya, Christopher Gillberg, Maria Rastam, Leonid Churilov, Sonja J McKeown, Nalzi Yalcinkaya, Petri Urvil, Tor Savidge, Carolyn A Bell, Oonagh Bodin, Jen Wood, Ashley E Franks, Joel C Bornstein, Elisa L Hill-Yardin

Journal article | 2019 | Autism Research

Co-treatment With BGP-15 Exacerbates 5-Fluorouracil-Induced Gastrointestinal Dysfunction

Rachel M McQuade, Maryam Al Thaalibi, Aaron C Petersen, Raquel Abalo, Joel C Bomstein, Emma Rybalka, Kulmira Nurgali

Journal article | 2019 | Frontiers in Neuroscience

Endogenous Glutamate Excites Myenteric Calbindin Neurons by Activating Group I Metabotropic Glutamate Receptors in the Mouse Colon

Mathusi Swaminathan, Elisa L Hill-Yardin, Joel C Bornstein, Jaime PP Foong

Journal article | 2019 | Frontiers in Neuroscience

Neonatal Antibiotics Disrupt Motility and Enteric Neural Circuits in Mouse Colon

Lin Y Hung, Prapaporn Boonma, Petra Unterweger, Pavitha Parathan, Anthony Haag, Ruth Ann Luna, Joel C Bornstein, Tor C Savidge, Jaime PP Foong

Journal article | 2019 | Cellular and Molecular Gastroenterology and Hepatology

Targeting eotaxin-1 and CCR3 receptor alleviates enteric neuropathy and colonic dysfunction in TNBS-induced colitis in guinea pigs.

RT Filippone, AM Robinson, V Jovanovska, R Stavely, V Apostolopoulos, JC Bornstein, K Nurgali

Journal article | 2018 | Neurogastroenterology & Motility

BACKGROUND: The accumulation of eosinophils is mediated by the chemokine receptor-3 (CCR3)-eotaxin axis. Increased expression of e..

Targeting eotaxin-1 and CCR3 receptor alleviates enteric neuropathy and colonic dysfunction in TNBS-induced colitis in guinea pigs

RT Filippone, AM Robinson, V Jovanovska, R Stavely, V Apostolopoulos, JC Bornstein, K Nurgali

Journal article | 2018 | NEUROGASTROENTEROLOGY AND MOTILITY

PARP inhibition in platinum-based chemotherapy: Chemopotentiation and neuroprotection

Rachel M McQuade, Vanesa Stojanovska, Joel C Bornstein, Kulmira Nurgali

Journal article | 2018 | Pharmacological Research

Exposure to the antibiotic, vancomycin perturbs gut microbiota, mucosal serotonin and enteric neuron development of the early postnatal mouse colon

JPP Foong, LY Hung, P Unterweger, P Parathan, B Prapaporn, A Haag, RA Luna, JC Bornstein, TC Savidge

Conference Proceedings | 2018 | NEUROGASTROENTEROLOGY AND MOTILITY

Perturbation of gut microbiota with the antibiotic, vancomycin, between weaning and adulthood affects enteric neuronal excitability and motility in the mouse colon

L-Y Hung, P Parathan, P Boonma, A Haag, RA Luna, JC Bornstein, T Savidge, JPP Foong

Conference Proceedings | 2018 | NEUROGASTROENTEROLOGY AND MOTILITY

Enteric nervous system as a therapeutic target to alleviate gastrointestinal side-effects of chemotherapy

K Nurgali, V Stojanovska, RM McQuade, AA Rahman, E Donald, A Robinson, D Myers, J Bornstein

Conference Proceedings | 2018 | NEUROGASTROENTEROLOGY AND MOTILITY

PERTURBING THE GUT MICROBIOTA IN MICE WITH THE ANTIBIOTIC, VANCOMYCIN, REDUCES SEROTONIN PRODUCTION AND ALTERS ENTERIC NERVOUS SYSTEM DEVELOPMENT IN EARLY POSTNATAL COLON

Lin Y Hung, Petra Unterweger, Pavitha Parathan, Prapoporn Boonma, Anthony Haag, Ruth Ann Luna, Joel C Bornstein, Tor C Savidge, Jaime Pei Pei Foong

Conference Proceedings | 2018 | GASTROENTEROLOGY

Enteric Neural Regulation of Mucosal Secretion

JC Bornstein, JPP Foong

Book Chapter | 2018

Cholinergic Submucosal Neurons Display Increased Excitability Following in Vivo Cholera Toxin Exposure in Mouse Ileum

Candice Fung, Katerina Koussoulas, Petra Unterweger, Andrew M Allen, Joel C Bornstein, Jaime PP Foong

Journal article | 2018 | FRONTIERS IN PHYSIOLOGY

Neurally Released GABA Acts via GABA(C) Receptors to Modulate Ca2 Transients Evoked by Trains of Synaptic Inputs, but Not Responses Evoked by Single Stimuli, in Myenteric Neurons of Mouse Ileum

Katerina Koussoulas, Mathusi Swaminathan, Candice Fung, Joel C Bornstein, Jaime PP Foong

Journal article | 2018 | Frontiers in Physiology

Oxaliplatin-induced enteric neuronal loss and intestinal dysfunction is prevented by co-treatment with BGP-15

Rachel M McQuade, Vanesa Stojanovska, Rhian Stavely, Cara Timpani, Aaron C Petersen, Raquel Abalo, Joel C Bornstein, Emma Rybalka, Kulmira Nurgali

Journal article | 2018 | British Journal of Pharmacology

Calcium Sensing Receptors Mediate Local Inhibitory Reflexes Evoked by L-Phenylalanine in Guinea Pig Jejunum

Rachel M Gwynne, Kenny DKN Ly, Laura J Parry, Joel C Bornstein

Journal article | 2017 | Frontiers in Physiology

The relation between cesarean birth and child cognitive development

Cain Polidano, Anna Zhu, Joel C Bornstein

Journal article | 2017 | SCIENTIFIC REPORTS

Cholera toxin-evoked sustained hyperexcitability in murine cholinergic submucosal neurons

C Fung, K Koussoulas, P Unteweger, A Allen, J Bornstein, J Foong

Conference Proceedings | 2017 | NEUROGASTROENTEROLOGY AND MOTILITY

Spontaneous calcium waves in the developing enteric nervous system

Marlene M Hao, Annette J Bergner, Caroline S Hirst, Lincon A Stamp, Franca Casagranda, Joel C Bornstein, Werend Boesmans, Pieter Vanden Berghe, Heather M Young

Journal article | 2017 | Developmental Biology

Irinotecan-Induced Gastrointestinal Dysfunction Is Associated with Enteric Neuropathy, but Increased Numbers of Cholinergic Myenteric Neurons

Rachel M McQuade, Vanesa Stojanovska, Elizabeth L Donald, Ahmed A Rahman, Dean G Campelj, Raquel Abalo, Emma Rybalka, Joel C Bornstein, Kulmira Nurgali

Journal article | 2017 | Frontiers in Physiology

Optogenetic Demonstration of Functional Innervation of Mouse Colon by Neurons Derived From Transplanted Neural Cells

Lincon A Stamp, Rachel M Gwynne, Jaime PP Foong, Alan E Lomax, Marlene M Hao, David I Kaplan, Christopher A Reid, Steven Petrou, Andrew M Allen, Joel C Bornstein, Heather M Young

Journal article | 2017 | Gastroenterology

Cholera Toxin Induces Sustained Hyperexcitability in Myenteric, but Not Submucosal, AH Neurons in Guinea Pig Jejunum

Katerina Koussoulas, Rachel M Gwynne, Jaime PP Foong, Joel C Bornstein

Journal article | 2017 | Frontiers in Physiology

VPAC Receptor Subtypes Tune Purinergic Neuron-to-Glia Communication in the Murine Submucosal Plexus

Candice Fung, Werend Boesmans, Carla Cirillo, Jaime PP Foong, Joel C Bornstein, Pieter Vanden Berghe

Journal article | 2017 | Frontiers in Cellular Neuroscience

Alterations of colonic function in the Winnie mouse model of spontaneous chronic colitis

Ainsley M Robinson, Ahmed A Rahman, Simona E Carbone, Sarron Randall-Demllo, Rhiannon Filippone, Joel C Bornstein, Rajaraman Eri, Kulmira Nurgali

Journal article | 2017 | American Journal of Physiology-Gastrointestinal and Liver Physiology

Colorectal Cancer Chemotherapy: The Evolution of Treatment and New Approaches

Rachel M McQuade, Vanesa Stojanovska, Joel C Bornstein, Kulmira Nurgali

Journal article | 2017 | Current Medicinal Chemistry

Role of oxidative stress in oxaliplatin-induced enteric neuropathy and colonic dysmotility in mice

Rachel M McQuade, Simona E Carbone, Vanesa Stojanovska, Ahmed Rahman, Rachel M Gwynne, Ainsley M Robinson, Craig A Goodman, Joel C Bornstein, Kulmira Nurgali

Journal article | 2016 | British Journal of Pharmacology

Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5-fluorouracil

RM McQuade, V Stojanovska, E Donald, R Abalo, JC Bornstein, K Nurgali

Journal article | 2016 | Neurogastroenterology & Motility

Development of gut motility

EA Beckett, HM Young, JC Bornstein, SR Jadcherla

Book Chapter | 2016

Chemotherapy-Induced Constipation and Diarrhea: Pathophysiology, Current and Emerging Treatments

Rachel M McQuade, Vanesa Stojanovska, Raquel Abalo, Joel C Bornstein, Kulmira Nurgali

Journal article | 2016 | Frontiers in Pharmacology

White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies

Alan J Burns, Allan M Goldstein, Donald F Newgreen, Lincon Stamp, Karl-Herbert Schaefer, Marco Metzger, Ryo Hotta, Heather M Young, Peter W Andrews, Nikhil Thapar, Jaime Belkind-Gerson, Nadege Bondurand, Joel C Bornstein, Wood Yee Chan, Kathryn Cheah, Michael D Gershon, Robert O Heuckeroth, Robert MW Hofstra, Lothar Just, Raj P Kapur, et al.

Journal article | 2016 | Developmental Biology

Enteric nervous system assembly: Functional integration within the developing gut

MM Hao, JPP Foong, JC Bornstein, ZL Li, R Vanden Berghe, W Boesmans

Journal article | 2016 | Developmental Biology

PSD-93 is expressed in most, but not all, myenteric neurons in the mouse colon

M Swaminathan, JPP Foong, EL Hill-Yardin, JC Bornstein

Conference Proceedings | 2016 | NEUROGASTROENTEROLOGY AND MOTILITY

A sexually dimorphic effect of cholera toxin: rapid changes in colonic motility mediated via a 5-HT3 receptor-dependent pathway in female C57Bl/6 mice

Gayathri K Balasuriya, Elisa L Hill-Yardin, Michael D Gershon, Joel C Bornstein

Journal article | 2016 | The Journal of Physiology

How prenatal synthetic glucocorticoids administration impacts the ENS in Wistar rats?

F Ramalhosa, R Gwynne, H Young, N Sousa, AF Carvalho, J Bornstein

Conference Proceedings | 2016 | NEUROGASTROENTEROLOGY AND MOTILITY

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

EL Hill-Yardin, undefined Swaminathan M, undefined Ellis M, undefined Zygorodimos M, undefined Johnston LA, undefined Gwynne RM, undefined Bornstein JC

Journal article | 2016 | Journal of Visualized Experiments

A neuroligin-3 mutation implicated in autism causes abnormal aggression and increases repetitive behavior in mice

Emma L Burrows, Liliana Laskaris, Lynn Koyama, Leonid Churilov, Joel C Bornstein, Elisa L Hill-Yardin, Anthony J Hannan

Journal article | 2015 | MOLECULAR AUTISM

Exposure to the antibiotic vancomycin modifies development of the enteric nervous system in early postnatal mice

J Bornstein, P Unterweger, JPP Foong

Conference Proceedings | 2015 | JOURNAL OF NEUROCHEMISTRY

Changes in Nicotinic Neurotransmission during Enteric Nervous System Development

Jaime Pei Pei Foong, Caroline S Hirst, Marlene M Hao, Sonja J McKeown, Werend Boesmans, Heather M Young, Joel C Bornstein, Pieter Vanden Berghe

Journal article | 2015 | JOURNAL OF NEUROSCIENCE

Zolpidem Confers Disease Susceptibility to Clostridium difficile Infection

Sara Dann, Samuel Aitken, Cana Ross, Mary Elizabeth M Tessier, Michael Loeffelholz, Katerina Koussoulas, Joel C Bornstein, Hanping Feng, James Versalovic, Charalabos Pothoulakis, Kevin W Garey, Tor Savidge

Conference Proceedings | 2015 | GASTROENTEROLOGY

Clostridium difficile Toxin and Microbial-Derived GABA Signals Converge to Hyperexcite Myenteric Intrinsic Sensory Neurons

Katerina Koussoulas, Rachel Gwynne, Jaime Pei Pei Foong, Cana Ross, Tor Savidge, Joel C Bornstein

Conference Proceedings | 2015 | Gastroenterology

Ion Channel Expression in the Developing Enteric Nervous System

Caroline S Hirst, Jaime PP Foong, Lincon A Stamp, Emily Fegan, Stephan Dent, Edward C Cooper, Alan E Lomax, Colin R Anderson, Joel C Bornstein, Heather M Young, Sonja J McKeown

Journal article | 2015 | PLOS ONE

Mesenchymal stem cells and conditioned medium avert enteric neuropathy and colon dysfunction in guinea pig TNBS-induced colitis

Ainsley M Robinson, Samy Sakkal, Anthony Park, Valentina Jovanovska, Natalie Payne, Simona E Carbone, Sarah Miller, Joel C Bornstein, Claude Bernard, Richard Boyd, Kulmira Nurgali

Journal article | 2014 | American Journal of Physiology-Gastrointestinal and Liver Physiology

Both exogenous 5-HT and endogenous 5-HT, released by flu oxetine, enhance distension evoked propulsion in guinea-pig ileum in vitro

Rachel M Gwynne, Amanda J Clarke, John B Furness, Joel C Bornstein

Journal article | 2014 | FRONTIERS IN NEUROSCIENCE

Anti-cancer chemotherapy: impact on the enteric nervous system

K Nurgali, R Mcquade, V Stojanovska, A Rahman, S Carbone, J Bornstein

Conference Proceedings | 2014 | NEUROGASTROENTEROLOGY AND MOTILITY

Mesenchymal stem cells and conditioned medium avert inflammation-induced enteric neuropathy

A Robinson, S Miller, S Sakkal, A Park, V Jovanovska, N Payne, S Carbone, J Bornstein, C Bernard, R Boyd, K Nurgali

Conference Proceedings | 2014 | NEUROGASTROENTEROLOGY AND MOTILITY

A detailed, conductance-based computer model of intrinsic sensory neurons of the gastrointestinal tract

Jordan D Chambers, Joel C Bornstein, Rachel M Gwynne, Katerina Koussoulas, Evan A Thomas

Journal article | 2014 | AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The development of cell-cell communication in the enteric nervous system: spontaneous calcium waves propagate between adjacent neural crest-derived cells

M Hao, A Bergner, C Hirst, L Stamp, J Bornstein, P Vanden Berghe, H Young

Conference Proceedings | 2014 | NEUROGASTROENTEROLOGY AND MOTILITY

Mucosal GABA excites local inhibitory reflexes and increases the excitability of myenteric intrinsic sensory neurons in the guinea pig jejunum via a GABAA receptor independent mechanism

J Bornstein, K Koussoulas, R Gwynne, P Unterweger, J Foong

Conference Proceedings | 2014 | NEUROGASTROENTEROLOGY AND MOTILITY

Agonist-Dependent Delta Opioid Receptor Trafficking and Signaling in Myenteric Neurons

Cathryn Claessen, Meritxell Canals, TinaMarie Lieu, Joel C Bornstein, Nigel W Bunnett, Daniel P Poole

Conference Proceedings | 2014 | GASTROENTEROLOGY

VPAC(1) receptors regulate intestinal secretion and muscle contractility by activating cholinergic neurons in guinea pig jejunum

Candice Fung, Petra Unterweger, Laura J Parry, Joel C Bornstein, Jaime PP Foong

Journal article | 2014 | AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Motility changes induced by intraluminal FeSO4 in guinea pig jejunum

K Wang, RL Bertrand, S Senadheera, KE Polglaze, TV Murphy, SL Sandow, L Liu, JC Bornstein, PP Bertrand

Journal article | 2014 | Neurogastroenterology and Motility

Mathematical modelling of enteric neural motor patterns

Jordan D Chambers, Evan A Thomas, Joel C Bornstein

Journal article | 2014 | Clinical and Experimental Pharmacology and Physiology

Properties of cholinergic and non-cholinergic submucosal neurons along the mouse colon

Jaime Pei Pei Foong, Iain R Tough, Helen M Cox, Joel C Bornstein

Journal article | 2014 | Journal of Physiology

Anti-Colorectal Cancer Chemotherapy-Induced Diarrhoea: Current Treatments and Side-Effects

Rachel M McQuade, Joel C Bornstein, Kulmira Nurgali

Journal article | 2014 | International Journal of Clinical Medicine

Development of myenteric cholinergic neurons in ChAT-Cre;R26R-YFP Mice

Marlene M Hao, Joel C Bornstein, Heather M Young

Journal article | 2013 | JOURNAL OF COMPARATIVE NEUROLOGY

The emergence of neural activity and its role in the development of the enteric nervous system

Marlene M Hao, Joel C Bornstein, Pieter Vanden Berghe, Alan E Lomax, Heather M Young, Jaime PP Foong

Journal article | 2013 | DEVELOPMENTAL BIOLOGY

Oxaliplatin-induced enteric neuropathy

R Mcquade, V Stojanovska, S Carbone, A Rahman, V Jovanovska, JC Bornstein, K Nurgali

Conference Proceedings | 2013 | NEUROGASTROENTEROLOGY AND MOTILITY

Nitric Oxide Mediated Colonic Motility Is Altered in the Neuroligin-3 R451c Mouse Model of Autism

Mathusi Swaminathan, Jaime Pei Pei Foong, Melina Ellis, Joel C Bornstein, Elisa L Hill-Yardin

Conference Proceedings | 2013 | GASTROENTEROLOGY

Gender Dependent Effects of Cholera Toxin on Colonic Motility - A Role for Sex Steroids

Gayathri K Balasuriya, Joel C Bornstein

Conference Proceedings | 2013 | GASTROENTEROLOGY

Vpac1 Receptors Localised to Cholinergic Secretomotor Neurons Regulate Intestinal Secretion in Guinea-Pig Jejunum

Candice Fung, Jaime Pei Pei Foong, Laura J Parry, Joel C Bornstein

Conference Proceedings | 2013 | GASTROENTEROLOGY

The Development and Maturation of Cholinergic Enteric Neurons - Begins Early, but Continues Postnatally

Marlene M Hao, Heather M Young, Joel C Bornstein

Conference Proceedings | 2013 | GASTROENTEROLOGY

Serotonin and cholecystokinin mediate nutrient-induced segmentation in guinea pig small intestine

Melina Ellis, Jordan D Chambers, Rachel M Gwynne, Joel C Bornstein

Journal article | 2013 | AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Transmission to Interneurons Is via Slow Excitatory Synaptic Potentials Mediated by P2Y(1) Receptors during Descending Inhibition in Guinea-Pig Ileum

Peter DJ Thornton, Rachel M Gwynne, Darren J McMillan, Joel C Bornstein

Journal article | 2013 | PLoS One

Effects of oxaliplatin on mouse myenteric neurons and colonic motility

Linah Wafai, Mohammadali Taher, Valentina Jovanovska, Joel C Bornstein, Crispin R Dass, Kulmira Nurgali

Journal article | 2013 | Frontiers in Neuroscience

Development of gut motility

HM Young, EA Beckett, JC Bornstein, SR Jadcherla

Book Chapter | 2013

Enteric Neural Regulation of Mucosal Secretion

JC Bornstein, RM Gwynne, H Sjövall

Book Chapter | 2012

Cholera toxin has a sexually dimorphic effect on colonic migrating motor complexes in mice

J Bornstein, G Balasuriya

Conference Proceedings | 2012 | NEUROGASTROENTEROLOGY AND MOTILITY

Eosinophils and eosinophil-regulatory molecules as therapeutic targets for the treatment of intestinal inflammation

K Nurgali, L Edmunds, M Taher, V Jovanovska, M Ellis, JC Bornstein

Journal article | 2012 | NEUROGASTROENTEROLOGY AND MOTILITY

Early Development of Electrical Excitability in the Mouse Enteric Nervous System

Marlene M Hao, Alan E Lomax, Sonja J McKeown, Christopher A Reid, Heather M Young, Joel C Bornstein

Journal article | 2012 | Journal of Neuroscience

Enteric Neurons Undergo Significant Electrophysiological and Morphological Changes During Postnatal Development

Jaime Pei Pei Foong, Trung V Nguyen, John B Furness, Joel C Bornstein, Heather M Young

Conference Proceedings | 2012 | GASTROENTEROLOGY

Myenteric neurons of the mouse small intestine undergo significant electrophysiological and morphological changes during postnatal development

Jaime Pei Pei Foong, Trung V Nguyen, John B Furness, Joel C Bornstein, Heather M Young

Journal article | 2012 | JOURNAL OF PHYSIOLOGY-LONDON

Cholera Toxin Increases Excitability of Myenteric, but Not Submucosal, AH Neurons in Guinea-Pig Jejunum

Katerina Koussoulas, Rachel Gwynne, Joel C Bornstein

Conference Proceedings | 2012 | GASTROENTEROLOGY

The Neuroligin 3 Arg451cys (Nl-3) Mouse Model of Autism Shows Altered Colonic Function In Vitro

Melina Ellis, Ali M Taher, Sonja McKeown, Elisa L Hill, Joel C Bornstein

Conference Proceedings | 2012 | GASTROENTEROLOGY

The Extracellular Calcium Sensing Receptor Mediates Local Inhibitory Reflexes Evoked by Aromatic L-Amino Acids in Guinea Pig Jejunum

Rachel Gwynne, Kenny Ly, Joel C Bornstein

Conference Proceedings | 2012 | GASTROENTEROLOGY

Diet and gastric neurons

Joel C Bornstein

Journal article | 2012 | Journal of Physiology

Autonomic Neuroscience: articles of interest appearing in other Frontiers journals

Vaughan G Macefield, Joel C Bornstein

Journal article | 2012 | Frontiers in Neuroscience

Serotonin in the gut: what does it do?

Joel C Bornstein

Journal article | 2012 | FRONTIERS IN NEUROSCIENCE

Early Emergence of Neural Activity in the Developing Mouse Enteric Nervous System

Marlene M Hao, Werend Boesmans, Valentine Van den Abbeel, Ernest A Jennings, Joel C Bornstein, Heather M Young, Pieter Vanden Berghe

Journal article | 2011 | Journal of Neuroscience

Endogenous peptide YY and neuropeptide Y inhibit colonic ion transport, contractility and transit differentially via Y-1 and Y-2 receptors

IR Tough, S Forbes, R Tolhurst, M Ellis, H Herzog, JC Bornstein, HM Cox

Journal article | 2011 | British Journal of Pharmacology

Multiple Neural Oscillators and Muscle Feedback Are Required for the Intestinal Fed State Motor Program

Jordan D Chambers, Joel C Bornstein, Evan A Thomas

Journal article | 2011 | PLoS One

Activation of neuronal SST1 and SST2 receptors decreases neurogenic secretion in the guinea-pig jejunum

JPP Foong, LJ Parry, JC Bornstein

Journal article | 2010 | Neurogastroenterology and Motility

Calcium imaging of developing enteric neurons

MM Hao, W Boesmans, V Van Den Abbeel, JC Bornstein, HM Young, P Vanden Berghe

Conference Proceedings | 2010 | NEUROGASTROENTEROLOGY AND MOTILITY

The first intestinal motility patterns in fetal mice are not mediated by neurons or interstitial cells of Cajal

Rachael R Roberts, Melina Ellis, Rachel M Gwynne, Annette J Bergner, Martin D Lewis, Elizabeth A Beckett, Joel C Bornstein, Heather M Young

Journal article | 2010 | Journal of Physiology

THE NEUROCHEMISTRY AND INNERVATION PATTERNS OF EXTRINSIC SENSORY AND SYMPATHETIC NERVES IN THE MYENTERIC PLEXUS OF THE C57BL6 MOUSE JEJUNUM

LL Tan, JC Bornstein, CR Anderson

Journal article | 2010 | Neuroscience

5-HT1A, SST1, and SST2 receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum

Jaime Pei Pei Foong, Laura J Parry, Rachel M Gwynne, Joel C Bornstein

Journal article | 2010 | AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Luminal cholera toxin alters motility in isolated guinea-pig jejunum via a pathway independent of 5-HT3 receptors

Candice Fung, Melina Ellis, Joel C Bornstein

Journal article | 2010 | Frontiers in Neuroscience

Nitric oxide enhances inhibitory synaptic transmission and neuronal excitability in guinea-pig submucous plexus

Joel C Bornstein, Kathryn A Marks, Jaime Pei Pei Foong, Rachel M Gwynne, Zhi Hong Wang

Journal article | 2010 | FRONTIERS IN NEUROSCIENCE

Development of the enteric nervous system and its role in intestinal motility during fetal and early postnatal stages

Alan J Burns, Rachael R Roberts, Joel C Bornstein, Heather M Young

Journal article | 2009 | Seminars in Pediatric Surgery

Indirect evidence for increased mechanosensitivity of jejunal secretomotor neurones in patients with idiopathic bile acid malabsorption

A Bajor, K-A Ung, L Ohman, M Simren, EA Thomas, JC Bornstein, H Sjovall

Journal article | 2009 | Acta Physiologica Scandinavica

Neurochemical and morphological phenotypes of vagal afferent neurons innervating the adult mouse jejunum

LL Tan, JC Bornstein, CR Anderson

Journal article | 2009 | Neurogastroenterology and Motility

Electrical stimulation of the mucosa evokes slow EPSPs mediated by NK1 tachykinin receptors and by P2Y(1) purinoceptors in different myenteric neurons

Rachel M Gwynne, Joel C Bornstein

Journal article | 2009 | American Journal of Physiology - Gastrointestinal and Liver Physiology

ROME III Subtyping Is Associated with Alterations in Intestinal Motility and Secretion, But Not with Sensitivity or Psychosocial Factors

Magnus Simren, Iris Posserud, Hasse Abrahamsson, Evan Thomas, Joel C Bornstein, Henrik Sjovall

Conference Proceedings | 2009 | GASTROENTEROLOGY

Interdigestive Secretion from the Small Intestine Is Selectively Enhanced in Idiopatic Bile Acid Malabsorption

Antal Bajor, Kjell-Arne Ung, Lena Ohman, Evan Thomas, Joel C Bornstein, Magnus Simren, Henrik Sjovall

Conference Proceedings | 2009 | GASTROENTEROLOGY

5-HT antagonists NAN-190 and SB 269970 block alpha(2)-adrenoceptors in the guinea pig

Jaime Pei Pei Foong, Joel C Bornstein

Journal article | 2009 | NEUROREPORT

Development of Neurons and the Role of Neural Activity in the Developing Gut

MM Hao, RE Moore, RB Anderson, JC Bornstein, EA Jennings, HM Young

Conference Proceedings | 2009 | NEUROGASTROENTEROLOGY AND MOTILITY

Strain-specific genetics, anatomy and function of enteric neural serotonergic pathways in inbred mice

Kathleen B Neal, Laura J Parry, Joel C Bornstein

Journal article | 2009 | Journal of Physiology

mGluR(1) receptors contribute to non-purinergic slow excitatory transmission to submucosal VIP neurons of guinea-pig ileum

Jaime Pei Pei Foong, Joel C Bornstein

Journal article | 2009 | Frontiers in Neuroscience

Cholera Toxin Induces Sustained Hyperexcitability in Submucosal Secretomotor Neurons in Guinea Pig Jejunum

Rachel M Gwynne, Melina Ellis, Henrik Sjovall, Joel C Bornstein

Journal article | 2009 | Gastroenterology

Autonomic Nervous System: Gastrointestinal Control

JC Bornstein

Book Chapter | 2009

Distinct chemical classes of medium-sized transient receptor potential channel vanilloid 1-immunoreactive dorsal root ganglion neurons innervate the adult mouse jejunum and colon

LL Tan, JC Bornstein, CR Anderson

Journal article | 2008 | Neuroscience

Synaptic transmission from the submucosal plexus to the myenteric plexus in Guinea-pig ileum

RL Monro, JC Bornstein, PP Bertrand

Journal article | 2008 | Neurogastroenterology and Motility

Purinergic mechanisms in the control of gastrointestinal motility

JC Bornstein

Journal article | 2008 | Purinergic Signalling

Insights into mechanisms of intestinal segmentation in guinea pigs: a combined computational modeling and in vitro study

Jordan D Chambers, Joel C Bornstein, Evan A Thomas

Journal article | 2008 | American Journal of Physiology - Gastrointestinal and Liver Physiology

Targets of myenteric interneurons in the guinea-pig small intestine

KB Neal, JC Bornstein

Journal article | 2008 | Neurogastroenterology and Motility

Cholera toxin induces long-term increases in excitability in VIP and NPY secretomotor neurons in guinea-pig jejunum via a mechanism involving 5-HT3 and NK1 receptors

Rachel Gwynne, Joel C Bornstein

Conference Proceedings | 2008 | GASTROENTEROLOGY

Strain-specific expression of Tph2 polymorphism in murine enteric neurons

Kath B Neal, Laura J Parry, Joel C Bornstein

Conference Proceedings | 2008 | GASTROENTEROLOGY

Disturbances of colonic motility in mouse models of Hirschsprung's disease

Rachael R Roberts, Joel C Bornstein, Annette J Bergner, Heather M Young

Journal article | 2008 | American Journal of Physiology - Gastrointestinal and Liver Physiology

Colonic motility, myenteric neuron density and nitric oxide synthase neuron density in mice with mutations in Hirschsprung's disease susceptibility genes

Rachael R Roberts, Joel C Bornstein, Annette J Bergner, Heather M Young

Conference Proceedings | 2008 | GASTROENTEROLOGY

Intrinsic inhibitory postsynaptic potentials in VIP neurons of the guinea-pig submucous plexus involve the activation of 5-HT1A and Sst(2) receptors

Pei Pei J Foong, Joel C Bornstein

Conference Proceedings | 2008 | GASTROENTEROLOGY

Primary afferent neurons innervating the adult mouse small and large intestines are mostly medium-sized and are marked by TRPV1, NOS, SP and CGRP

Linette L Tan, Joel C Bornstein, Colin R Anderson

Conference Proceedings | 2008 | GASTROENTEROLOGY

Pharmacological analysis of components of the change in transmural potential difference evoked by distension of rat proximal small intestine in vivo

Marie H Larsson, Maria Sapnara, Evan A Thomas, Joel C Bornstein, Erik Lindstrom, David J Svensson, Henrik Sjovall

Journal article | 2008 | American Journal of Physiology - Gastrointestinal and Liver Physiology

Elevated motility-related transmucosal potential difference in the upper small intestine in the irritable bowel syndrome

MH Larsson, M Simren, EA Thomas, JC Bornstein, E Lindstroem, H Sjoevall

Journal article | 2007 | Neurogastroenterology and Motility

Strain differences in Tph2 genotype in murine myenteric neurons

Kathleen B Neal, Joel C Bornstein

Journal article | 2007 | Autonomic Neuroscience

Local inhibitory reflexes excited by mucosal application of nutrient amino acids in guinea pig jejunum

RM Gwynne, JC Bornstein

Journal article | 2007 | American Journal of Physiology - Gastrointestinal and Liver Physiology

Loss of bowel motility following massive small bowel resection in piglets

Bridget R Southwell, Katherine Neal, Joel C Bornstein, Julie Bines

Conference Proceedings | 2007 | GASTROENTEROLOGY

Effects of GDNF and Ret haploinsufficiency on motility in the colon of developing and adult mice

Rachael Roberts, Joel C Bornstein, Heather Young

Conference Proceedings | 2007 | GASTROENTEROLOGY

Mechanisms underlying nutrient-induced segmentation in isolated guinea pig small intestine

RM Gwynne, JC Bornstein

Journal article | 2007 | American Journal of Physiology - Gastrointestinal and Liver Physiology

Mechanisms underlying nutrient-induced segmentation within the gut are not well understood. We have shown that decanoic acid and s..

Mechanisms underlying nutrient-induced segmentation in isolated guinea pig small intestine

RM Gwynne, JC Bornstein

Journal article | 2007 | American Journal of Physiology - Gastrointestinal and Liver Physiology

Mapping 5-HT inputs to enteric neurons of the guinea-pig small intestine

KB Neal, JC Bornstein

Journal article | 2007 | Neuroscience

Development of colonic motility in the neonatal mouse-studies using spatiotemporal maps

Rachael R Roberts, Jessica F Murphy, Heather M Young, Joel C Bornstein

Journal article | 2007 | American Journal of Physiology - Gastrointestinal and Liver Physiology

Synaptic Transmission at Functionally Identified Synapses in the Enteric Nervous System: Roles for Both Ionotropic and Metabotropic Receptors

R Gwynne, J Bornstein

Journal article | 2007 | Current Neuropharmacology

Synaptic transmission at functionally identified synapses in the enteric nervous system: Roles for both ionotropic and metabotropic receptors

RM Gwynne, JC Bornstein

Journal article | 2007 | Current Neuropharmacology

Serotonergic receptors in therapeutic approaches to gastrointestinal disorders

Kathleen Bronwyn Neal, Joel Charles Bornstein

Journal article | 2006 | Current Opinion in Pharmacology

Intrinsic sensory neurons of mouse gut - Toward a detailed knowledge of enteric neural circuitry across species. Focus on "characterization of myenteric sensory neurons in the mouse small intestine"

Joel C Bornstein

Journal article | 2006 | Journal of Neurophysiology

Effects of cholera toxin on the potential difference and motor responses induced by distension in the rat proximal small intestine in vivo

S Kordasti, M Sapnara, EA Thomas, E Lindstrom, M Forsman, JC Bornstein, H Sjovall

Journal article | 2006 | American Journal of Physiology - Gastrointestinal and Liver Physiology