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The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for ..
Analysing Enteric Neuronal Activity In Order To Identify Treatments For Gastrointestinal I..
Internal Research Grant
Colonic dilation and altered ex vivo gastrointestinal motility in the neuroligin-3 knockou..
Displaying the 18 most recent projects by Joel Bornstein.
Internal Research Grant
Displaying the 288 most recent scholarly works by Joel Bornstein.
Antibiotic exposure postweaning disrupts the neurochemistry and function of enteric neurons mediating colonic motor activity.
Lin Y Hung, Pavitha Parathan, Prapaporn Boonma, Qinglong Wu, Yi Wang, Anthony Haag, Ruth Ann Luna, Joel C Bornstein, Tor C Savidge, Jaime PP Foong
Journal article | 2020 | American Journal of Physiology-Gastrointestinal and Liver Physiology
The period during and immediately after weaning is an important developmental window when marked shifts in gut microbiota can regu..
Colonic dilation and altered ex vivo gastrointestinal motility in the neuroligin-3 knockout mouse
Anita JL Leembruggen, Gayathri K Balasuriya, Jinghong Zhang, Shana Schokman, Kristy Swiderski, Joel C Bornstein, Jess Nithianantharajah, Elisa L Hill-Yardin
Journal article | 2020 | AUTISM RESEARCH
Gastrointestinal (GI) dysfunction is commonly reported by people diagnosed with autism spectrum disorder (ASD; autism) but the cau..
Chemotherapy-induced enteric neuropathy and gastrointestinal dysfunction: Mechanisms and novel treatments
Rachel M McQuade, Vanesa Stojanovska, Rhiannon Filippone, Lauren Shakian, Nyanbol Kuol, Majid Hassanzadeganroudsari, Joel C Bornstein, Mark R Kelley, Kulmira Nurgali
Conference Proceedings | 2020 | NEUROGASTROENTEROLOGY AND MOTILITY
The enteric nervous system undergoes significant chemical and synaptic maturation during adolescence in mice
Pavitha Parathan, Yi Wang, Anita JL Leembruggen, Joel C Bornstein, Jaime PP Foong
Journal article | 2020 | Developmental Biology
Adolescence is a critical period of development. It is very likely that there is significant maturation of the enteric nervous sys..
Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in mdx Dystrophic Mice Ameliorated by Oral L-arginine Supplementation
Kristy Swiderski, Rebecka Bindon, Jennifer Trieu, Timur Naim, Shana Schokman, Mathusi Swaminathan, Anita JL Leembruggen, Elisa L Hill-Yardin, Rene Koopman, Joel C Bornstein, Gordon S Lynch
Journal article | 2020 | Journal of Neurogastroenterology and Motility
Background/Aims: Patients with Duchenne muscular dystrophy exhibit significant, ongoing impairments in gastrointestinal (GI) funct..
alpha-Synuclein Regulates Development and Function of Cholinergic Enteric Neurons in the Mouse Colon
M Swaminathan, C Fung, D Finkelstein, JC Bornstein, JPP Foong
Journal article | 2019 | Neuroscience
Alpha-Synuclein (α-Syn) is expressed in the central nervous system and the nervous system of the gut (enteric nervous system, ENS)..
Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3
Suzanne Hosie, Melina Ellis, Mathusi Swaminathan, Fatima Ramalhosa, Gracia O Seger, Gayathri K Balasuriya, Christopher Gillberg, Maria Rastam, Leonid Churilov, Sonja J McKeown, Nalzi Yalcinkaya, Petri Urvil, Tor Savidge, Carolyn A Bell, Oonagh Bodin, Jen Wood, Ashley E Franks, Joel C Bornstein, Elisa L Hill-Yardin
Journal article | 2019 | Autism Research
Neonatal Antibiotics Disrupt Motility and Enteric Neural Circuits in Mouse Colon
Lin Y Hung, Prapaporn Boonma, Petra Unterweger, Pavitha Parathan, Anthony Haag, Ruth Ann Luna, Joel C Bornstein, Tor C Savidge, Jaime PP Foong
Journal article | 2019 | Cellular and Molecular Gastroenterology and Hepatology
Targeting eotaxin-1 and CCR3 receptor alleviates enteric neuropathy and colonic dysfunction in TNBS-induced colitis in guinea pigs.
RT Filippone, AM Robinson, V Jovanovska, R Stavely, V Apostolopoulos, JC Bornstein, K Nurgali
Journal article | 2018 | Neurogastroenterology & Motility
BACKGROUND: The accumulation of eosinophils is mediated by the chemokine receptor-3 (CCR3)-eotaxin axis. Increased expression of e..
Exposure to the antibiotic, vancomycin perturbs gut microbiota, mucosal serotonin and enteric neuron development of the early postnatal mouse colon
JPP Foong, LY Hung, P Unterweger, P Parathan, B Prapaporn, A Haag, RA Luna, JC Bornstein, TC Savidge
Conference Proceedings | 2018 | NEUROGASTROENTEROLOGY AND MOTILITY
Perturbation of gut microbiota with the antibiotic, vancomycin, between weaning and adulthood affects enteric neuronal excitability and motility in the mouse colon
L-Y Hung, P Parathan, P Boonma, A Haag, RA Luna, JC Bornstein, T Savidge, JPP Foong
Conference Proceedings | 2018 | NEUROGASTROENTEROLOGY AND MOTILITY
PERTURBING THE GUT MICROBIOTA IN MICE WITH THE ANTIBIOTIC, VANCOMYCIN, REDUCES SEROTONIN PRODUCTION AND ALTERS ENTERIC NERVOUS SYSTEM DEVELOPMENT IN EARLY POSTNATAL COLON
Lin Y Hung, Petra Unterweger, Pavitha Parathan, Prapoporn Boonma, Anthony Haag, Ruth Ann Luna, Joel C Bornstein, Tor C Savidge, Jaime Pei Pei Foong
Conference Proceedings | 2018 | GASTROENTEROLOGY
Neurally Released GABA Acts via GABA(C) Receptors to Modulate Ca2 Transients Evoked by Trains of Synaptic Inputs, but Not Responses Evoked by Single Stimuli, in Myenteric Neurons of Mouse Ileum
Katerina Koussoulas, Mathusi Swaminathan, Candice Fung, Joel C Bornstein, Jaime PP Foong
Journal article | 2018 | Frontiers in Physiology
Oxaliplatin-induced enteric neuronal loss and intestinal dysfunction is prevented by co-treatment with BGP-15
Rachel M McQuade, Vanesa Stojanovska, Rhian Stavely, Cara Timpani, Aaron C Petersen, Raquel Abalo, Joel C Bornstein, Emma Rybalka, Kulmira Nurgali
Journal article | 2018 | British Journal of Pharmacology
Irinotecan-Induced Gastrointestinal Dysfunction Is Associated with Enteric Neuropathy, but Increased Numbers of Cholinergic Myenteric Neurons
Rachel M McQuade, Vanesa Stojanovska, Elizabeth L Donald, Ahmed A Rahman, Dean G Campelj, Raquel Abalo, Emma Rybalka, Joel C Bornstein, Kulmira Nurgali
Journal article | 2017 | Frontiers in Physiology
Optogenetic Demonstration of Functional Innervation of Mouse Colon by Neurons Derived From Transplanted Neural Cells
Lincon A Stamp, Rachel M Gwynne, Jaime PP Foong, Alan E Lomax, Marlene M Hao, David I Kaplan, Christopher A Reid, Steven Petrou, Andrew M Allen, Joel C Bornstein, Heather M Young
Journal article | 2017 | Gastroenterology
Alterations of colonic function in the Winnie mouse model of spontaneous chronic colitis
Ainsley M Robinson, Ahmed A Rahman, Simona E Carbone, Sarron Randall-Demllo, Rhiannon Filippone, Joel C Bornstein, Rajaraman Eri, Kulmira Nurgali
Journal article | 2017 | American Journal of Physiology-Gastrointestinal and Liver Physiology
Role of oxidative stress in oxaliplatin-induced enteric neuropathy and colonic dysmotility in mice
Rachel M McQuade, Simona E Carbone, Vanesa Stojanovska, Ahmed Rahman, Rachel M Gwynne, Ainsley M Robinson, Craig A Goodman, Joel C Bornstein, Kulmira Nurgali
Journal article | 2016 | British Journal of Pharmacology
White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies
Alan J Burns, Allan M Goldstein, Donald F Newgreen, Lincon Stamp, Karl-Herbert Schaefer, Marco Metzger, Ryo Hotta, Heather M Young, Peter W Andrews, Nikhil Thapar, Jaime Belkind-Gerson, Nadege Bondurand, Joel C Bornstein, Wood Yee Chan, Kathryn Cheah, Michael D Gershon, Robert O Heuckeroth, Robert MW Hofstra, Lothar Just, Raj P Kapur, et al.
Journal article | 2016 | Developmental Biology
Zolpidem Confers Disease Susceptibility to Clostridium difficile Infection
Sara Dann, Samuel Aitken, Cana Ross, Mary Elizabeth M Tessier, Michael Loeffelholz, Katerina Koussoulas, Joel C Bornstein, Hanping Feng, James Versalovic, Charalabos Pothoulakis, Kevin W Garey, Tor Savidge
Conference Proceedings | 2015 | GASTROENTEROLOGY
Mesenchymal stem cells and conditioned medium avert enteric neuropathy and colon dysfunction in guinea pig TNBS-induced colitis
Ainsley M Robinson, Samy Sakkal, Anthony Park, Valentina Jovanovska, Natalie Payne, Simona E Carbone, Sarah Miller, Joel C Bornstein, Claude Bernard, Richard Boyd, Kulmira Nurgali
Journal article | 2014 | American Journal of Physiology-Gastrointestinal and Liver Physiology
Mucosal GABA excites local inhibitory reflexes and increases the excitability of myenteric intrinsic sensory neurons in the guinea pig jejunum via a GABAA receptor independent mechanism
J Bornstein, K Koussoulas, R Gwynne, P Unterweger, J Foong
Conference Proceedings | 2014 | NEUROGASTROENTEROLOGY AND MOTILITY
VPAC(1) receptors regulate intestinal secretion and muscle contractility by activating cholinergic neurons in guinea pig jejunum
Candice Fung, Petra Unterweger, Laura J Parry, Joel C Bornstein, Jaime PP Foong
Journal article | 2014 | AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Pharmacological analysis of components of the change in transmural potential difference evoked by distension of rat proximal small intestine in vivo
Marie H Larsson, Maria Sapnara, Evan A Thomas, Joel C Bornstein, Erik Lindstrom, David J Svensson, Henrik Sjovall
Journal article | 2008 | American Journal of Physiology - Gastrointestinal and Liver Physiology
Mechanisms underlying nutrient-induced segmentation in isolated guinea pig small intestine
RM Gwynne, JC Bornstein
Journal article | 2007 | American Journal of Physiology - Gastrointestinal and Liver Physiology
Mechanisms underlying nutrient-induced segmentation within the gut are not well understood. We have shown that decanoic acid and s..
Effects of cholera toxin on the potential difference and motor responses induced by distension in the rat proximal small intestine in vivo
S Kordasti, M Sapnara, EA Thomas, E Lindstrom, M Forsman, JC Bornstein, H Sjovall
Journal article | 2006 | American Journal of Physiology - Gastrointestinal and Liver Physiology
Analysis of the responses of myenteric neurons in the small intestine to chemical stimulation of the mucosa.
PP Bertrand, WA Kunze, JC Bornstein, JB Furness, ML Smith
Journal article | 1997 | American Journal of Physiology-Gastrointestinal and Liver Physiology
Responses of myenteric AH and S neurons to local application of chemicals to the mucosa of the guinea pig small intestine were obt..
Projections of 5-hydroxytryptamine-immunoreactive neurons in guinea-pig distal colon.
CF Wardell, JC Bornstein, JB Furness
Journal article | 1994 | Cell and Tissue Research
The presence of 5-hydroxytryptamine in enteric neurons of the guinea-pig distal colon was demonstrated by immunohistochemistry and..
Electrophysiology and enkephalin immunoreactivity of identified myenteric plexus neurones of guinea-pig small intestine.
JC Bornstein, M Costa, JB Furness, GM Lees
Journal article | 1984 | The Journal of Physiology
Intracellular injection of the fluorescent dye, Lucifer Yellow CH, revealed the shapes of neurones in the myenteric plexus of the ..
American Gastroenterological Association
International Society for Autonomic Neuroscience
Australian Neuroscience Society
American Association for the Advancement of Science
Doctor of Philosophy
Bachelor of Science Honours