Joel Bornstein

Early life interaction between the microbiota and the enteric nervous system

Jaime PP Foong, Lin Y Hung, Sabrina Poon, Tor C Savidge, Joel C Bornstein

Journal article  |  2020  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Recent studies on humans and their key experimental model, the mouse, have begun to uncover the importance of gastrointestinal (GI..

Inhibition of APE1/Ref-1 Redox Signaling Alleviates Intestinal Dysfunction and Damage to Myenteric Neurons in a Mouse Model of Spontaneous Chronic Colitis.

Lauren Sahakian, Rhiannon T Filippone, Rhian Stavely, Ainsley M Robinson, Xu Sean Yan, Raquel Abalo, Rajaraman Eri, Joel C Bornstein, Mark R Kelley, Kulmira Nurgali

Journal article  |  2020  |  Inflammatory Bowel Diseases

BACKGROUND: Inflammatory bowel disease (IBD) associates with damage to the enteric nervous system (ENS), leading to gastrointestin..

Antibiotic exposure postweaning disrupts the neurochemistry and function of enteric neurons mediating colonic motor activity.

Lin Y Hung, Pavitha Parathan, Prapaporn Boonma, Qinglong Wu, Yi Wang, Anthony Haag, Ruth Ann Luna, Joel C Bornstein, Tor C Savidge, Jaime PP Foong

Journal article  |  2020  |  AJP Gastrointestinal and Liver Physiology

The period during and immediately after weaning is an important developmental window when marked shifts in gut microbiota can regu..

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders

Madushani Herath, Suzanne Hosie, Joel C Bornstein, Ashley E Franks, Elisa L Hill-Yardin

Journal article  |  2020  |  Frontiers in Cellular and Infection Microbiology

Colonic dilation and altered ex vivo gastrointestinal motility in the neuroligin-3 knockout mouse

Anita JL Leembruggen, Gayathri K Balasuriya, Jinghong Zhang, Shana Schokman, Kristy Swiderski, Joel C Bornstein, Jess Nithianantharajah, Elisa L Hill-Yardin

Journal article  |  2020  |  Autism Research: official journal of the International Society for Autism Research

Gastrointestinal (GI) dysfunction is commonly reported by people diagnosed with autism spectrum disorder (ASD; autism) but the cau..

Apurinic/apyrimidinic endonuclease 1/redox factor-1 as a novel therapeutic target for inflammatory bowel disease

Lauren Sahakian, Rhiannon Filippone, Xu Yan, Raquel Abalo, Rajaraman Eri, Joel Bornstein, Mark Kelley, Kulmira Nurgali

Conference Proceedings  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

Chemotherapy-induced enteric neuropathy and gastrointestinal dysfunction: Mechanisms and novel treatments

Rachel M McQuade, Vanesa Stojanovska, Rhiannon Filippone, Lauren Shakian, Nyanbol Kuol, Majid Hassanzadeganroudsari, Joel C Bornstein, Mark R Kelley, Kulmira Nurgali

Conference Proceedings  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

The enteric nervous system undergoes significant chemical and synaptic maturation during adolescence in mice

Pavitha Parathan, Yi Wang, Anita JL Leembruggen, Joel C Bornstein, Jaime PP Foong

Journal article  |  2020  |  Developmental Biology

Adolescence is a critical period of development. It is very likely that there is significant maturation of the enteric nervous sys..

Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in mdx Dystrophic Mice Ameliorated by Oral L-arginine Supplementation

Kristy Swiderski, Rebecka Bindon, Jennifer Trieu, Timur Naim, Shana Schokman, Mathusi Swaminathan, Anita JL Leembruggen, Elisa L Hill-Yardin, Rene Koopman, Joel C Bornstein, Gordon S Lynch

Journal article  |  2020  |  Journal of Neurogastroenterology and Motility

Background/Aims: Patients with Duchenne muscular dystrophy exhibit significant, ongoing impairments in gastrointestinal (GI) funct..

alpha-Synuclein Regulates Development and Function of Cholinergic Enteric Neurons in the Mouse Colon

M Swaminathan, C Fung, D Finkelstein, JC Bornstein, JPP Foong

Journal article  |  2019  |  Neuroscience

Alpha-Synuclein (α-Syn) is expressed in the central nervous system and the nervous system of the gut (enteric nervous system, ENS)..