Joel Bornstein

Group I Metabotropic Glutamate Receptors Modulate Motility and Enteric Neural Activity in the Mouse Colon

Anita JL Leembruggen, Yuqing Lu, Haozhe Wang, Volkan Uzungil, Thibault Renoir, Anthony JJ Hannan, Lincon AA Stamp, Marlene MM Hao, Joel CC Bornstein

Journal article  |  2023  |  BIOMOLECULES

Glutamate is the major excitatory neurotransmitter in the central nervous system, and there is evidence that Group-I metabotropic ..

Oxidative Stress-Induced HMGB1 Translocation in Myenteric Neurons Contributes to Neuropathy in Colitis

Rhian Stavely, Lauren Sahakian, Rhiannon TT Filippone, Vanesa Stojanovska, Joel CC Bornstein, Samy Sakkal, Kulmira Nurgali

Journal article  |  2022  |  BIOMOLECULES

High-mobility group box 1 (HMGB1) is a damage-associated molecular pattern released by dying cells to stimulate the immune respons..

Neonatal antibiotics have long term sex-dependent effects on the enteric nervous system

Sabrina SB Poon, Lin Y Hung, Qinglong Wu, Pavitha Parathan, Nazli Yalcinkaya, Anthony Haag, Ruth Ann Luna, Joel C Bornstein, Tor C Savidge, Jaime PP Foong

Journal article  |  2022  |  JOURNAL OF PHYSIOLOGY-LONDON

Infants and young children receive the highest exposures to antibiotics globally. Although there is building evidence that early l..

Potent CCR3 Receptor Antagonist, SB328437, Suppresses Colonic Eosinophil Chemotaxis and Inflammation in the Winnie Murine Model of Spontaneous Chronic Colitis

Rhiannon T Filippone, Narges Dargahi, Rajaraman Eri, Jose A Uranga, Joel C Bornstein, Vasso Apostolopoulos, Kulmira Nurgali

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Eosinophils and their regulatory molecules have been associated with chronic intestinal inflammation and gastrointestinal dysfunct..

Computational simulations and Ca2 imaging reveal that slow synaptic depolarizations (slow EPSPs) inhibit fast EPSP evoked action potentials for most of their time course in enteric neurons

Parvin Zarei Eskikand, Katerina Koussoulas, Rachel M Gwynne, Joel C Bornstein

Journal article  |  2022  |  PLOS COMPUTATIONAL BIOLOGY

Transmission between neurons in the extensive enteric neural networks of the gut involves synaptic potentials with vastly differen..

Divergent Adaptations in Autonomic Nerve Activity and Neuroimmune Signaling Associated With the Severity of Inflammation in Chronic Colitis

Rhian Stavely, Ahmed A Rahman, Lauren Sahakian, Monica D Prakash, Ainsley M Robinson, Majid Hassanzadeganroudsari, Rhiannon T Filippone, Sarah Fraser, Rajaraman Eri, Joel C Bornstein, Vasso Apostolopoulos, Kulmira Nurgali

Journal article  |  2022  |  INFLAMMATORY BOWEL DISEASES

BACKGROUND: The autonomic nervous system (ANS) is thought to play a critical role in the anti-inflammatory reflex pathway in acute..

Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease

Colin F Craig, Rhiannon T Filippone, Rhian Stavely, Joel C Bornstein, Vasso Apostolopoulos, Kulmira Nurgali

Journal article  |  2022  |  JOURNAL OF NEUROINFLAMMATION

Patients with inflammatory bowel disease (IBD) suffer from depression at higher rates than the general population. An etiological ..

Correction to: Enteric neuroimmune interactions coordinate intestinal responses in health and disease.

Haozhe Wang, Jaime PP Foong, Nicola L Harris, Joel C Bornstein

Journal article  |  2022  |  Mucosal Immunol

The original version of this article unfortunately was missing requisite credit lines in Figs. 1–4. Images presented in Fig. 1 ada..

Circadian Control of Gastrointestinal Motility.

Anita JL Leembruggen, Lincon A Stamp, Joel C Bornstein, Marlene M Hao

Book Chapter  |  2022  |  Advances in Experimental Medicine and Biology

With the earth's 24-h rotation cycle, physiological function fluctuates in both diurnal and nocturnal animals, thereby ensuring op..

Molecular Targets to Alleviate Enteric Neuropathy and Gastrointestinal Dysfunction.

Lauren Sahakian, Rachel McQuade, Rhian Stavely, Ainsley Robinson, Rhiannon T Filippone, Majid Hassanzadeganroudsari, Raj Eri, Raquel Abalo, Joel C Bornstein, Mark R Kelley, Kulmira Nurgali

Book Chapter  |  2022  |  Advances in Experimental Medicine and Biology

Enteric neuropathy underlies long-term gastrointestinal (GI) dysfunction associated with several pathological conditions. Our prev..