Joel Bornstein

Enteric neuroimmune interactions coordinate intestinal responses in health and disease

Haozhe Wang, Jaime PP Foong, Nicola L Harris, Joel C Bornstein

Journal article  |  2021  |  MUCOSAL IMMUNOLOGY

The enteric nervous system (ENS) of the gastrointestinal (GI) tract interacts with the local immune system bidirectionally. Recent..

83 NEONATAL ANTIBIOTICS HAVE LONG TERM SEX-DEPENDENT EFFECTS ON THE ENTERIC NERVOUS SYSTEM AND METABOLISM

Sabrina S Poon, Lin Y Hung, Qinglong Wu, Pavitha Parathan, Anthony Haag, Ruth Ann Luna, Matthew J Watt, Tor C Savidge, Joel C Bornstein, Jaime Pei Pei Foong

Journal article  |  2021  |  Gastroenterology

Inhibition of APE1/Ref-1 Redox Signaling Alleviates Intestinal Dysfunction and Damage to Myenteric Neurons in a Mouse Model of Spontaneous Chronic Colitis

Lauren Sahakian, Rhiannon T Filippone, Rhian Stavely, Ainsley M Robinson, Xu Sean Yan, Raquel Abalo, Rajaraman Eri, Joel C Bornstein, Mark R Kelley, Kulmira Nurgali

Journal article  |  2021  |  INFLAMMATORY BOWEL DISEASES

BACKGROUND: Inflammatory bowel disease (IBD) associates with damage to the enteric nervous system (ENS), leading to gastrointestin..

scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3

Christina M Wright, Sabine Schneider, Kristen M Smith-Edwards, Fernanda Mafra, Anita JL Leembruggen, Michael Gonzalez, Deepika R Kothakapa, Jessica B Anderson, Beth A Maguire, Tao Gao, Tricia A Missall, Marthe J Howard, Joel C Bornstein, Brian M Davis, Robert O Heuckeroth

Journal article  |  2021  |  CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY

BACKGROUND AND AIMS: Bowel function requires coordinated activity of diverse enteric neuron subtypes. Our aim was to define gene e..

Early life interaction between the microbiota and the enteric nervous system

Jaime PP Foong, Lin Y Hung, Sabrina Poon, Tor C Savidge, Joel C Bornstein

Journal article  |  2020  |  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Recent studies on humans and their key experimental model, the mouse, have begun to uncover the importance of gastrointestinal (GI..

Antibiotic exposure postweaning disrupts the neurochemistry and function of enteric neurons mediating colonic motor activity

Lin Y Hung, Pavitha Parathan, Prapaporn Boonma, Qinglong Wu, Yi Wang, Anthony Haag, Ruth Ann Luna, Joel C Bornstein, Tor C Savidge, Jaime PP Foong

Journal article  |  2020  |  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The period during and immediately after weaning is an important developmental window when marked shifts in gut microbiota can regu..

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders

Madushani Herath, Suzanne Hosie, Joel C Bornstein, Ashley E Franks, Elisa L Hill-Yardin

Journal article  |  2020  |  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

Mucus is integral to gut health and its properties may be affected in neurological disease. Mucus comprises a hydrated network of ..

Colonic dilation and altered ex vivo gastrointestinal motility in the neuroligin-3 knockout mouse

Anita JL Leembruggen, Gayathri K Balasuriya, Jinghong Zhang, Shana Schokman, Kristy Swiderski, Joel C Bornstein, Jess Nithianantharajah, Elisa L Hill-Yardin

Journal article  |  2020  |  AUTISM RESEARCH

Gastrointestinal (GI) dysfunction is commonly reported by people diagnosed with autism spectrum disorder (ASD; autism) but the cau..

Apurinic/apyrimidinic endonuclease 1/redox factor-1 as a novel therapeutic target for inflammatory bowel disease

Lauren Sahakian, Rhiannon Filippone, Xu Yan, Raquel Abalo, Rajaraman Eri, Joel Bornstein, Mark Kelley, Kulmira Nurgali

Conference Proceedings  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

Chemotherapy-induced enteric neuropathy and gastrointestinal dysfunction: Mechanisms and novel treatments

Rachel M McQuade, Vanesa Stojanovska, Rhiannon Filippone, Lauren Shakian, Nyanbol Kuol, Majid Hassanzadeganroudsari, Joel C Bornstein, Mark R Kelley, Kulmira Nurgali

Conference Proceedings  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY