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Prof

Anthony Wedd

Honorary
Chemistry
Copper proteins
trace metals
iron
molybdenum
Polyoxometalates
clusters
photochemistry
catalysis
science & technology
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Prof

Anthony Wedd

 
Division
Science
 
Primary Interest
Polyoxo-metalate chemistry
Anthony Wedd's Profile Picture
Prof

Anthony Wedd

 
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Anthony's  Short Profile
 

Projects

Displaying the 10 most recent projects from 14 for Anthony Wedd.

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How does Redox Cycling Drive the Metabolism of the Essential Metals Iron and Copper?

Intriguingly, some enzymes handle both iron and copper and this project will develop new methods for their study. The work will lead ultimat..

2013 - 2016
Completed
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Redox Sulfur Chemistry in Copper Nutrition

Problems with metabolism of the nutrient metal copper are associated with many diseases including tuberculosis, heart disease and Alzheimer'..

2012 - 2015
Completed
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Chemistry of the Transport of Nutrient Copper in Biological Cells

Nutrient trace metals such as copper are needed for enzymes by living organisms but are toxic in excess. Defects in copper metabolism cause ..

2010 - 2014
Completed
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EXTENDING FRONTIERS OF STRUCTURAL CHEMISTRY AND BIOLOGY THROUGH HIGH RESOLUTION PULSED ELECTRON PARAMAGNETIC RESONANCE

Multifrequency high resolution pulsed Electron Paramagnetic Resonance (EPR) instrumentation will provide forefront technologies in identifyi..

2013 - 2014
Completed
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EXTENDING FRONTIERS OF STRUCTURAL CHEMISTRY AND BIOLOGY THROUGH HIGH RESOLUTION PULSED ELECTRON PARAMAGNETIC RESONANCE

Multifrequency high resolution pulsed Electron Paramagnetic Resonance (EPR) instrumentation will provide forefront technologies in identifyi..

2013 - 2013
Completed
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Molecular Probes for Bio-Metals

The nutrient trace metals are essential to life. Problems with the metabolism of iron, copper and zinc are associated with neuro-degenerativ..

2008 - 2012
Completed
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TO ENGAGE IN COLLABORATIVE TESTING TO DETERMINE METHODS OF PROCESSING CERTAIN WASTE MATERIALS

2011 - 2011
Completed
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Enhanced Capacity in Ultra-Trace Level Detection and Speciation of Compounds of Environmental, Biological and Materials Science Interest

The proposed integrated facility will strongly support collaborative research in areas of high national priority. These are environmental su..

2009 - 2009
Completed
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INVESTIGATING PROTEIN/PROTEIN INTERACTIONS

To establish and maintain a prominent position in scientific research, Australian scientists must have access to state of the art technology..

2008 - 2009
Completed
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Polyoxometalate clusters: catalytic chemistry in solution and condensed states

Polyoxometalate cluster anions are soluble metal-oxygen clusters that are cheap, robust and non-toxic. Conditions for systematic tuning of r..

14

Projects

Project Types

12

Research Grant

2

Research Contracts

Scholarly Works

Displaying the 10 most recent scholarly works from 210 for Anthony Wedd.

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9 COPING WITH TOXIC METALS

Zhiguang Xiao, Anthony G Wedd

Book Chapter  |  2021

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The crystal structure of the CopC protein from Pseudomonas fluorescens reveals amended classifications for the CopC protein family

Saumya R Udagedara, Chathuri JK Wijekoon, Zhiguang Xiao, Anthony G Wedd, Megan J Maher

Journal article  |  2019  |  JOURNAL OF INORGANIC BIOCHEMISTRY

The bacterial CopC family of proteins are periplasmic copper binding proteins that act in copper detoxification. These proteins co..

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Molecular Mechanisms of Glutaredoxin Enzymes: Versatile Hubs for Thiol-Disulfide Exchange between Protein Thiols and Glutathione

Zhiguang Xiao, Sharon La Fontaine, Ashley I Bush, Anthony G Wedd

Journal article  |  2019  |  JOURNAL OF MOLECULAR BIOLOGY

The tripeptide glutathione (GSH) and its oxidized form glutathione disulfide (GSSG) constitute a key redox couple in cells. In par..

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The Human Amyloid Precursor Protein Binds Copper Ions Dominated by a Picomolar-Affinity Site in the Helix-Rich E2 Domain

Tessa R Young, Tara L Pukala, Roberto Cappai, Anthony G Wedd, Zhiguang Xiao

Journal article  |  2018  |  BIOCHEMISTRY

A manifestation of Alzheimer's disease (AD) is the aggregation in the brain of amyloid β (Aβ) peptides derived from the amyloid pr..

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Glutaredoxins employ parallel monothiol-dithiol mechanisms to catalyze thiol-disulfide exchanges with protein disulfides

Ashwinie A Ukuwela, Ashley I Bush, Anthony G Wedd, Zhiguang Xiao

Journal article  |  2018  |  CHEMICAL SCIENCE

Glutaredoxins (Grxs) are a family of glutathione (GSH)-dependent thiol-disulfide oxidoreductases. They feature GSH-binding sites t..

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C-F bond activation of trifluoroethanol and trifluoroacetic acid catalysed by the dimolybdate anion, [Mo2O6(F)](-)

George N Khairallah, Tom Waters, Anthony G Wedd, Richard AJ O'Hair

Journal article  |  2018  |  EUROPEAN JOURNAL OF MASS SPECTROMETRY

Two gas-phase catalytic cycles involving C-F bond activation of trifluoroethanol and trifluoroacetic acid were detected by multist..

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Evaluation of Cu(I) binding to the E2 domain of the amyloid precursor protein - a lesson in quantification of metal binding to proteins via ligand competition

Tessa R Young, Anthony G Wedd, Zhiguang Xiao

Journal article  |  2018  |  METALLOMICS

The extracellular domain E2 of the amyloid precursor protein (APP) features a His-rich metal-binding site (denoted as the M1 site)..

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Reduction potentials of protein disulfides and catalysis of glutathionylation and deglutathionylation by glutaredoxin enzymes

Ashwinie A Ukuwela, Ashley I Bush, Anthony G Wedd, Zhiguang Xiao

Journal article  |  2017  |  BIOCHEMICAL JOURNAL

Glutaredoxins (Grxs) are a class of GSH (glutathione)-dependent thiol-disulfide oxidoreductase enzymes. They use the cellular redo..

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Molecular Aspects of a Robust Assay for Ferroxidase Function of Ceruloplasmin

Laura Cortes, Blaine R Roberts, Anthony G Wedd, Zhiguang Xiao

Journal article  |  2017  |  INORGANIC CHEMISTRY

Ceruloplasmin (Cp) is one of the most complex multicopper oxidase enzymes and plays an essential role in the metabolism of iron in..

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Copper ATPase CopA from Escherichia coli: Quantitative Correlation between ATPase Activity and Vectorial Copper Transport

Chathuri JK Wijekoon, Saumya R Udagedara, Roland L Knorr, Rumiana Dimova, Anthony G Wedd, Zhiguang Xiao

Journal article  |  2017  |  Journal of the American Chemical Society

Cu-ATPases are membrane copper transporters present in all kingdoms of life. They play a central role in Cu homeostasis by pumping..

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Scholarly Works

Keyword Analysis

Expanding Knowledge
Inorganic Chemistry
Analytical Chemistry
Biochemistry and Cell Biology
Medicinal and Biomolecular Chemistry
Neurosciences
Other Chemical Sciences
Chemical Engineering
Other Health
Automotive Engineering

Honours, Awards and Fellowships

2004

FRACI - Fellow of the Royal Australian Chemical Institute

1

Award

Credentials

Positions

Honorary

Chemistry

Certified

American Chemical Society

Certified

Royal Australian Chemical Institute

Education

Bachelor of Science

University of Tasmania

Doctor of Science

University of Tasmania

Doctor of Philosophy

University of Tasmania

International Linkages

University of Florence

Italy

University of Lisbon

Portugal

Stanford University

United States

Imperial College of Science Technology and Medicine

United Kingdom