Aaron Jex

Single-Cell Transcriptomics To Define Plasmodium falciparum Stage Transition in the Mosquito Midgut

Mubasher Mohammed, Alexis Dziedziech, Vaishnovi Sekar, Medard Ernest, Thiago Luiz Silva, Balu Balan, S Noushin Emami, Inna Biryukova, Marc R Friedlaender, Aaron Jex, Marcelo Jacobs-Lorena, Johan Henriksson, Joel Vega-Rodriguez, Johan Ankarklev

Journal article  |  2023  |  MICROBIOLOGY SPECTRUM

Malaria inflicts the highest rate of morbidity and mortality among the vector-borne diseases. The dramatic bottleneck of parasite ..

Conservation, abundance, glycosylation profile, and localization of the TSP protein family in Cryptosporidium parvum.

Alan John, Stefanie M Bader, Niccolay Madiedo Soler, Kharizta Wiradiputri, Swapnil Tichkule, Sean T Smyth, Stuart A Ralph, Aaron R Jex, Nichollas E Scott, Christopher J Tonkin, Ethan D Goddard-Borger

Journal article  |  2023  |  J Biol Chem

Cryptosporidium parvum is a zoonotic apicomplexan parasite and a common cause of diarrheal disease worldwide. The development of v..

Drug susceptibility testing for oxygen-dependent and oxygen-independent resistance phenotypes in trichomonads.

Alexander YF Lam, Ernest Lacey, Vesna De Petra, Deborah A Williamson, Jan Šlapeta, Aaron R Jex, Samantha J Emery-Corbin

Journal article  |  2023  |  Int J Parasitol

Trichomonas vaginalis is the most prevalent, non-viral sexually transmitted human infection, causing 170 million cases of trichomo..

American variants of Cryptosporidium hominis: Over-sexed and over here?

Aaron R Jex, Kevin M Tyler

Journal article  |  2023  |  Cell Host Microbe

A new study in this issue of Cell Host & Microbe from Huang et al. provides important insights into the global epidemiology of hum..

Iron Supplementation May Selectively Reprofile the Gut Microbiome in Iron-Deficient Bangladeshi Infants

Andrew J Baldi, Sant-Rayn Pasricha, Aaron R Jex, M Imrul Hasan, Naomi Jones, Marilou Barrios, Sabine Braat, Jena Hamadani, Stephen Wilcox, Beverley-Ann Biggs, Rory Bowden

Journal article  |  2022  |  BLOOD

VIVID A Web Application for Variant Interpretation and Visualization in Multi-dimensional Analyses

Swapnil Tichkule, Yoochan Myung, Myo T Naung, Brendan RE Ansell, Andrew J Guy, Namrata Srivastava, Somya Mehra, Simone M Caccio, Ivo Mueller, Alyssa E Barry, Cock van Oosterhout, Bernard Pope, David B Ascher, Aaron R Jex

Journal article  |  2022  |  MOLECULAR BIOLOGY AND EVOLUTION

Large-scale comparative genomics- and population genetic studies generate enormous amounts of polymorphism data in the form of DNA..

Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets

Anthony A Ruberto, Steven P Maher, Amelie Vantaux, Chester J Joyner, Caitlin Bourke, Balu Balan, Aaron Jex, Ivo Mueller, Benoit Witkowski, Dennis E Kyle

Journal article  |  2022  |  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

The resilience of Plasmodium vivax, the most widely-distributed malaria-causing parasite in humans, is attributed to its ability t..

Single-cell RNA sequencing of Plasmodium vivax sporozoites reveals stage- and species-specific transcriptomic signatures

Anthony A Ruberto, Caitlin Bourke, Amelie Vantaux, Steven P Maher, Aaron Jex, Benoit Witkowski, Georges Snounou, Ivo Mueller

Journal article  |  2022  |  PLOS NEGLECTED TROPICAL DISEASES

BACKGROUND: Plasmodium vivax sporozoites reside in the salivary glands of a mosquito before infecting a human host and causing mal..

Recent genetic exchanges and admixture shape the genome and population structure of the zoonotic pathogen Cryptosporidium parvum

Giulia Corsi, Swapnil Tichkule, Anna Rosa Sannella, Paolo Vatta, Francesco Asnicar, Nicola Segata, Aaron R Jex, Cock van Oosterhout, Simone M Caccio

Journal article  |  2022  |  MOLECULAR ECOLOGY

Cryptosporidium parvum is a globally distributed zoonotic pathogen and a major cause of diarrhoeal disease in humans and ruminants..

Precise gene models using long-read sequencing reveal a unique poly(A) signal in Giardia lamblia.

Danielle Y Bilodeau, Ryan M Sheridan, Balu Balan, Aaron R Jex, Olivia S Rissland

Journal article  |  2022  |  RNA

During pre-mRNA processing, the poly(A) signal is recognized by a protein complex that ensures precise cleavage and polyadenylatio..