Gad Abraham

Author Correction: Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke.

Gad Abraham, Rainer Malik, Ekaterina Yonova-Doing, Agus Salim, Tingting Wang, John Danesh, Adam S Butterworth, Joanna MM Howson, Michael Inouye, Martin Dichgans

Journal article  |  2020  |  Nature Communications

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

Gad Abraham, Rainer Malik, Ekaterina Yonova-Doing, Agus Salim, Tingting Wang, John Danesh, Adam S Butterworth, Joanna MM Howson, Michael Inouye, Martin Dichgans

Journal article  |  2019  |  Nature Communications

Recent genome-wide association studies in stroke have enabled the generation of genomic risk scores (GRS) but their predictive pow..

Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy

Artika P Nath, Scott C Ritchie, Nastasiya F Grinberg, Howard Ho-Fung Tang, Qin Qin Huang, Shu Mei Teo, Ari V Ahola-Olli, Peter Wurtz, Aki S Havulinna, Kristiina Santalahti, Niina Pitkanen, Terho Lehtimaki, Mika Kahonen, Leo-Pekka Lyytikainen, Emma Raitoharju, Ilkka Seppala, Antti-Pekka Sarin, Samuli Ripatti, Aarno Palotie, Markus Perola, et al.

Journal article  |  2019  |  The American Journal of Human Genetics

Cytokines are essential regulatory components of the immune system, and their aberrant levels have been linked to many disease sta..

Towards clinical utility of polygenic risk scores

Samuel A Lambert, Gad Abraham, Michael Inouye

Journal article  |  2019  |  Human Molecular Genetics

Prediction of disease risk is an essential part of preventative medicine, often guiding clinical management. Risk prediction typic..

Elevated serum alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality.

Scott C Ritchie, Johannes Kettunen, Marta Brozynska, Artika P Nath, Aki S Havulinna, Satu Männistö, Markus Perola, Veikko Salomaa, Mika Ala-Korpela, Gad Abraham, Peter Würtz, Michael Inouye

Journal article  |  2019  |  PLOS ONE

BACKGROUND: GlycA is a nuclear magnetic resonance (NMR) spectroscopy biomarker that predicts risk of disease from myriad causes. I..

Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults Implications for Primary Prevention

Michael Inouye, Gad Abraham, Christopher P Nelson, Angela M Wood, Michael J Sweeting, Frank Dudbridge, Florence Y Lai, Stephen Kaptoge, Marta Brozynska, Tingting Wang, Shu Ye, Thomas R Webb, Martin K Rutter, Ioanna Tzoulaki, Riyaz S Patel, Ruth JF Loos, Bernard Keavney, Harry Hemingway, John Thompson, Hugh Watkins, et al.

Journal article  |  2018  |  Journal of the American College of Cardiology

FlashPCA2: principal component analysis of Biobank-scale genotype datasets

Gad Abraham, Yixuan Qiu, Michael Inouye

Journal article  |  2017  |  Bioinformatics

An interaction map of circulating metabolites, immune gene networks, and their genetic regulation

Artika P Nath, Scott C Ritchie, Sean G Byars, Liam G Fearnley, Aki S Havulinna, Anni Joensuu, Antti J Kangas, Pasi Soininen, Annika Wennerstrom, Lili Milani, Andres Metspalu, Satu Mannisto, Peter Wurtz, Johannes Kettunen, Emma Raitoharju, Mika Kahonen, Markus Juonala, Aarno Palotie, Mika Ala-Korpela, Samuli Ripatti, et al.

Journal article  |  2017  |  Genome Biology

Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy

Sean G Byars, Qin Qin Huang, Lesley-Ann Gray, Andrew Bakshi, Samuli Ripatti, Gad Abraham, Stephen C Stearns, Michael Inouye

Journal article  |  2017  |  PLOS Genetics

Interactions within the MHC contribute to the genetic architecture of celiac disease

Benjamin Goudey, Gad Abraham, Eder Kikianty, Qiao Wang, Dave Rawlinson, Fan Shi, Izhak Haviv, Linda Stern, Adam Kowalczyk, Michael Inouye

Journal article  |  2017  |  PLOS ONE

FlashPCA2: principal component analysis of biobank-scale genotype datasets

Gad Abraham, Yixuan Qiu, Michael Inouye

Journal article  |  2016

Motivation Principal component analysis (PCA) is a crucial step in quality control of genomic data and a common approach for under..

Genomic prediction of coronary heart disease

Gad Abraham, Aki S Havulinna, Oneil G Bhalala, Sean G Byars, Alysha M De Livera, Laxman Yetukuri, Emmi Tikkanen, Markus Perola, Heribert Schunkert, Eric J Sijbrands, Aarno Palotie, Nilesh J Samani, Veikko Salomaa, Samuli Ripatti, Michael Inouye

Journal article  |  2016  |  European Heart Journal

A Scalable Permutation Approach Reveals Replication and Preservation Patterns of Network Modules in Large Datasets

Scott C Ritchie, Stephen Watts, Liam G Fearnley, Kathryn E Holt, Gad Abraham, Michael Inouye

Journal article  |  2016  |  Cell Systems

The Biomarker GlycA Is Associated with Chronic Inflammation and Predicts Long-Term Risk of Severe Infection

Scott C Ritchie, Peter Wurtz, Artika P Nath, Gad Abraham, Aki S Havulinna, Liam G Fearnley, Antti-Pekka Sarin, Antti J Kangas, Pasi Soininen, Kristiina Aalto, Ilkka Seppala, Emma Raitoharju, Marko Salmi, Mikael Maksimow, Satu Mannisto, Mika Kahonen, Markus Juonala, Samuli Ripatti, Terho Lehtimaki, Sirpa Jalkanen, et al.

Journal article  |  2015  |  Cell Systems

Genomic risk prediction of complex human disease and its clinical application

Gad Abraham, Michael Inouye

Journal article  |  2015  |  Current Opinion in Genetics & Development

Genomic prediction of celiac disease targeting HLA-positive individuals

Gad Abraham, Alexia Rohmer, Jason A Tye-Din, Michael Inouye

Journal article  |  2015  |  Genome Medicine

Towards a Molecular Systems Model of Coronary Artery Disease

Gad Abraham, Oneil G Bhalala, Paul IW de Bakker, Samuli Ripatti, Michael Inouye

Journal article  |  2014  |  Current Cardiology Reports

Fast Principal Component Analysis of Large-Scale Genome-Wide Data

Gad Abraham, Michael Inouye

Journal article  |  2014  |  PLoS ONE

Accurate and Robust Genomic Prediction of Celiac Disease Using Statistical Learning

Gad Abraham, Jason A Tye-Din, Oneil G Bhalala, Adam Kowalczyk, Justin Zobel, Michael Inouye

Journal article  |  2014  |  PLoS Genetics

Look, no hands! Spectral biomarkers from genetic association studies

Michael Inouye, Gad Abraham

Journal article  |  2013  |  Genome Medicine: medicine in the post-genomic era

Performance and Robustness of Penalized and Unpenalized Methods for Genetic Prediction of Complex Human Disease

Gad Abraham, Adam Kowalczyk, Justin Zobel, Michael Inouye

Journal article  |  2013  |  Genetic Epidemiology

SparSNP: Fast and memory-efficient analysis of all SNPs for phenotype prediction

Gad Abraham, Adam Kowalczyk, Justin Zobel, Michael Inouye

Journal article  |  2012  |  BMC Bioinformatics

Meta-analysis of gene expression microarrays with missing replicates

Fan Shi, Gad Abraham, Christopher Leckie, Izhak Haviv, Adam Kowalczyk

Journal article  |  2011  |  BMC Bioinformatics

Precision Medicine: Dawn of Supercomputing in ‘omics Research

M Reumann, KE Holt, M Inouye, T Stinear, B Goudey, G Abraham, Q WANG, F Shi, A Kowalczyk, A Pearce, A Isaac, BJ Pope, H Butzkueven, J Wagner, S Moore, M Downton, PC Church, SJ Turner, J Field, M Southey, et al.

Conference Proceedings  |  2011

Prediction of breast cancer prognosis using gene set statistics provides signature stability and biological context

Gad Abraham, Adam Kowalczyk, Sherene Loi, Izhak Haviv, Justin Zobel

Journal article  |  2010  |  BMC Bioinformatics

Short-Term Forecasting of Emergency Inpatient Flow

Gad Abraham, Graham B Byrnes, Christopher A Bain

Journal article  |  2009  |  IEEE Transactions on Information Technology in Biomedicine