Gad Abraham

Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses

Luanluan Sun, Lisa Pennells, Stephen Kaptoge, Christopher P Nelson, Scott C Ritchie, Gad Abraham, Matthew Arnold, Steven Bell, Thomas Bolton, Stephen Burgess, Frank Dudbridge, Qi Guo, Eleni Sofianopoulou, David Stevens, John R Thompson, Adam S Butterworth, Angela Wood, John Danesh, Nilesh J Samani, Michael Inouye, et al.

Journal article  |  2021  |  PLOS Medicine

BACKGROUND: Polygenic risk scores (PRSs) can stratify populations into cardiovascular disease (CVD) risk groups. We aimed to quant..

Genomic risk scores for juvenile idiopathic arthritis and its subtypes

Rodrigo Canovas, Joanna Cobb, Marta Brozynska, John Bowes, Yun R Li, Samantha Louise Smith, Hakon Hakonarson, Wendy Thomson, Justine A Ellis, Gad Abraham, Jane E Munro, Michael Inouye

Journal article  |  2020  |  Annals of the Rheumatic Diseases

OBJECTIVES: Juvenile idiopathic arthritis (JIA) is an autoimmune disease and a common cause of chronic disability in children. Dia..

GENOMIC RISK SCORES FOR PREDICTING JUVENILE IDIOPATHIC ARTHRITIS

Rodrigo Canovas, Gad Abraham, Joanna Cobb, Marta Brozynska, John Bowes, Samantha Smith, Justine Ellis, Hakon Hakonarson, Wendy Thomson, Michael Inouye, Jane Munro

Conference Proceedings  |  2020  |  INTERNAL MEDICINE JOURNAL

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

Gad Abraham, Rainer Malik, Ekaterina Yonova-Doing, Agus Salim, Tingting Wang, John Danesh, Adam S Butterworth, Joanna MM Howson, Michael Inouye, Martin Dichgans

Journal article  |  2019  |  Nature Communications

Recent genome-wide association studies in stroke have enabled the generation of genomic risk scores (GRS) but their predictive pow..

Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy

Artika P Nath, Scott C Ritchie, Nastasiya F Grinberg, Howard Ho-Fung Tang, Qin Qin Huang, Shu Mei Teo, Ari V Ahola-Olli, Peter Wurtz, Aki S Havulinna, Kristiina Santalahti, Niina Pitkanen, Terho Lehtimaki, Mika Kahonen, Leo-Pekka Lyytikainen, Emma Raitoharju, Ilkka Seppala, Antti-Pekka Sarin, Samuli Ripatti, Aarno Palotie, Markus Perola, et al.

Journal article  |  2019  |  American Journal of Human Genetics

Cytokines are essential regulatory components of the immune system, and their aberrant levels have been linked to many disease sta..

Elevated serum alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality

Scott C Ritchie, Johannes Kettunen, Marta Brozynska, Artika P Nath, Aki S Havulinna, Satu Maennist, Markus Perola, Veikko Salomaa, Mika Ala-Korpela, Gad Abraham, Peter Wuertz, Michael Inouye

Journal article  |  2019  |  PLoS One

BACKGROUND: GlycA is a nuclear magnetic resonance (NMR) spectroscopy biomarker that predicts risk of disease from myriad causes. I..

Towards clinical utility of polygenic risk scores

Samuel A Lambert, Gad Abraham, Michael Inouye

Journal article  |  2019  |  Human Molecular Genetics

Prediction of disease risk is an essential part of preventative medicine, often guiding clinical management. Risk prediction typic..

Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults Implications for Primary Prevention

Michael Inouye, Gad Abraham, Christopher P Nelson, Angela M Wood, Michael J Sweeting, Frank Dudbridge, Florence Y Lai, Stephen Kaptoge, Marta Brozynska, Tingting Wang, Shu Ye, Thomas R Webb, Martin K Rutter, Ioanna Tzoulaki, Riyaz S Patel, Ruth JF Loos, Bernard Keavney, Harry Hemingway, John Thompson, Hugh Watkins, et al.

Journal article  |  2018  |  Journal of the American College of Cardiology

FlashPCA2: principal component analysis of Biobank-scale genotype datasets

Gad Abraham, Yixuan Qiu, Michael Inouye

Journal article  |  2017  |  Bioinformatics

An interaction map of circulating metabolites, immune gene networks, and their genetic regulation

Artika P Nath, Scott C Ritchie, Sean G Byars, Liam G Fearnley, Aki S Havulinna, Anni Joensuu, Antti J Kangas, Pasi Soininen, Annika Wennerstrom, Lili Milani, Andres Metspalu, Satu Mannisto, Peter Wurtz, Johannes Kettunen, Emma Raitoharju, Mika Kahonen, Markus Juonala, Aarno Palotie, Mika Ala-Korpela, Samuli Ripatti, et al.

Journal article  |  2017  |  Genome Biology