Paul Adlard

Tailored behavioural tests reveal early and progressive cognitive deficits in M1000 prion disease.

Matteo Senesi, Victoria Lewis, Paul A Adlard, David I Finkelstein, Jee Hyun Kim, Steven J Collins

Journal article  |  2023  |  Neurobiol Dis

Prion diseases are pathogenically linked to the normal cellular prion protein (PrPC) misfolding into abnormal conformers (PrPSc), ..

Deferiprone attenuates neuropathology and improves outcome following traumatic brain injury

Maria Daglas, Phan H Truong, Linh Q Miles, Sydney MA Juan, Shalini S Rao, Paul A Adlard

Journal article  |  2022  |  BRITISH JOURNAL OF PHARMACOLOGY

BACKGROUND AND PURPOSE: Traumatic brain injury (TBI) remains a leading cause of mortality and morbidity in young adults. The role ..

ATH434 Rescues Pre-motor Hyposmia in a Mouse Model of Parkinsonism

Leah C Beauchamp, Xiang M Liu, Laura J Vella, Paul A Adlard, Ashley Bush, David Finkelstein, Kevin J Barnham

Journal article  |  2022  |  NEUROTHERAPEUTICS

Hyposmia is a prevalent prodromal feature of Parkinson's disease (PD), though the neuropathology that underlies this symptom is po..

Altered amyloid precursor protein, tau-regulatory proteins, neuronal numbers and behaviour, but no tau pathology, synaptic and inflammatory changes or memory deficits, at 1 month following repetitive mild traumatic brain injury

Sydney MA Juan, Maria Daglas, Paul A Adlard

Journal article  |  2022  |  EUROPEAN JOURNAL OF NEUROSCIENCE

Repetitive mild traumatic brain injury, commonly experienced following sports injuries, results in various secondary injury proces..

Tau Pathology, Metal Dyshomeostasis and Repetitive Mild Traumatic Brain Injury: An Unexplored Link Paving the Way for Neurodegeneration

Sydney MA Juan, Maria Daglas, Paul A Adlard

Journal article  |  2022  |  JOURNAL OF NEUROTRAUMA

Repetitive mild traumatic brain injury (r-mTBI), commonly experienced by athletes and military personnel, causes changes in multip..

The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy

David Finkelstein, Jay J Shukla, Robert A Cherny, Jessica L Billings, Eiman Saleh, Nadia Stefanova, Kevin J Barnham, Paul A Adlard

Journal article  |  2022  |  JOURNAL OF PARKINSONS DISEASE

BACKGROUND: An elevation in iron levels, together with an accumulation of α-synuclein within the oligodendrocytes, are features of..

Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology (vol 18, pg 1081, 2021)

Shalini S Rao, Larissa Lago, Irene Volitakis, Jay J Shukla, Gawain McColl, David I Finkelstein, Paul A Adlard

Journal article  |  2021  |  NEUROTHERAPEUTICS

In this article Figs. 3, 4, and 5 have been updated.

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease (vol 5, 53, 2017)

David I Finkelstein, Jessica L Billings, Paul A Adlard, Scott Ayton, Amelia Sedjahtera, Colin L Masters, Simon Wilkins, David M Shackleford, Susan A Charman, Wojciech Bal, Izabela A Zawisza, Ewa Kurowska, Andrew L Gundlach, Sheri Ma, Ashley I Bush, Dominic J Hare, Philip A Doble, Simon Crawford, Elisabeth CL Gautier, Jack Parsons, et al.

Journal article  |  2021  |  ACTA NEUROPATHOLOGICA COMMUNICATIONS

Following publication of the original article [1], the author identified an error in Fig. 4E. The data and statistics were correct..

Exercise ameliorates aberrant synaptic plasticity without enhancing adult-born cell survival in the hippocampus of serotonin transporter knockout mice

Carey Wilson, Jake Rogers, Feng Chen, Shanshan Li, Paul A Adlard, Anthony J Hannan, Thibault Renoir

Journal article  |  2021  |  BRAIN STRUCTURE & FUNCTION

Deficits in hippocampal cellular and synaptic plasticity are frequently associated with cognitive and mood disorders, and indeed c..

Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology

Shalini S Rao, Larissa Lago, Irene Volitakis, Jay J Shukla, Gawain McColl, David I Finkelstein, Paul A Adlard

Journal article  |  2021  |  NEUROTHERAPEUTICS

The accumulation of neurofibrillary tangles (NFTs), which is composed of abnormally hyperphosphorylated tau aggregates, is the cla..