Paul Adlard

Exercise ameliorates aberrant synaptic plasticity without enhancing adult-born cell survival in the hippocampus of serotonin transporter knockout mice

Carey Wilson, Jake Rogers, Feng Chen, Shanshan Li, Paul A Adlard, Anthony J Hannan, Thibault Renoir

Journal article  |  2021  |  Brain Structure and Function

Deficits in hippocampal cellular and synaptic plasticity are frequently associated with cognitive and mood disorders, and indeed c..

Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology

Shalini S Rao, Larissa Lago, Irene Volitakis, Jay J Shukla, Gawain McColl, David I Finkelstein, Paul A Adlard

Journal article  |  2021  |  Neurotherapeutics

The accumulation of neurofibrillary tangles (NFTs), which is composed of abnormally hyperphosphorylated tau aggregates, is the cla..

Fibrillar alpha-synuclein toxicity depends on functional lysosomes

Stephanie J Guiney, Paul A Adlard, Peng Lei, Celeste H Mawal, Ashley Bush, David Finkelstein, Scott Ayton

Journal article  |  2020  |  Journal of Biological Chemistry

Neurodegeneration in Parkinson's disease (PD) can be recapitulated in animals by administration of α-synuclein pre-formed fibrils ..

PrPSc Oligomerization Appears Dynamic, Quickly Engendering Inherent M1000 Acute Synaptotoxicity

Simote T Foliaki, Victoria Lewis, Abu MT Islam, Matteo Senesi, David Finkelstein, Laura J Ellett, Victoria A Lawson, Paul A Adlard, Blaine R Roberts, Steven J Collins

Journal article  |  2020  |  Biophysical Journal

Prion diseases are neurodegenerative disorders pathogenically linked to cellular prion protein (PrPC) misfolding into abnormal con..

Adrenergic beta receptor activation reduces amyloid beta(1-42)-mediated intracellular Zn2 toxicity in dentate granule cells followed by rescuing impairment of dentate gyrus LTP

Haruna Tamano, Yudai Ishikawa, Aoi Shioya, Ryusei Itoh, Naoya Oneta, Ryota Shimaya, Mako Egawa, Paul A Adlard, Ashley Bush, Atsushi Takeda

Journal article  |  2020  |  NeuroToxicology

Adrenergic β receptor activation prevents human soluble amyloid β (Aβ)-induced impairment of long-term potentiation (LTP) in slice..

Alzheimer risk factors age and female sex induce cortical A beta aggregation by raising extracellular zinc

Zsolt Datki, Zita Galik-Olah, Emese Janosi-Mozes, Viktor Szegedi, Janos Kalman, Akos Gabor Hunya, Livia Fulop, Haruna Tamano, Atsushi Takeda, Paul A Adlard, Ashley Bush

Journal article  |  2020  |  Molecular Psychiatry

Aging and female sex are the major risk factors for Alzheimer's disease and its associated brain amyloid-β (Aβ) neuropathology, bu..

Preferential Neurodegeneration in the Dentate Gyrus by Amyloid beta(1-42)-Induced Intracellular Zn(2 )Dysregulation and Its Defense Strategy

Haruna Tamano, Mako Takiguchi, Yukino Tanaka, Taku Murakami, Paul A Adlard, Ashley I Bush, Atsushi Takeda

Journal article  |  2020  |  Molecular Neurobiology

On the basis of the evidence that rapid intracellular Zn2+ dysregulation by amyloid β1-42 (Aβ1-42) in the normal hippocampus trans..

Matching sensitivity to abundance: high resolution immuno-mass spectrometry imaging of lanthanide labels and endogenous elements in the murine brain

David Clases, Raquel Gonzalez de Vega, Sabrina Funke, Thomas E Lockwood, Mika T Westerhausen, R Verena Taudte, Paul A Adlard, Philip A Doble

Journal article  |  2020  |  Journal of Analytical Atomic Spectrometry

This work introduces a new method for immuno-mass spectrometry imaging via quadrupole-based laser ablation-inductively coupled pla..

The Long Isoform of Intersectin-1 Has a Role in Learning and Memory

Nakisa Malakooti, Melanie A Pritchard, Feng Chen, Yong Yu, Charlotte Sgambelloni, Paul A Adlard, David I Finkelstein

Journal article  |  2020  |  Frontiers in Behavioral Neuroscience

Down syndrome is caused by partial or total trisomy of chromosome 21 and is characterized by intellectual disability and other dis..

Characterising the spatial and temporal brain metal profile in a mouse model of tauopathy

Shalini S Rao, Larissa Lago, Raquel Gonzalez de Vega, Lisa Bray, Dominic J Hare, David Clases, Philip A Doble, Paul A Adlard

Journal article  |  2020  |  Metallomics

A dysregulation in the homeostasis of metals such as copper, iron and zinc is speculated to be involved in the pathogenesis of tau..