Paul Adlard

Characterising the spatial and temporal brain metal profile in a mouse model of tauopathy

Shalini S Rao, Larissa Lago, Raquel Gonzalez de Vega, Lisa Bray, Dominic J Hare, David Clases, Philip A Doble, Paul A Adlard

Journal article  |  2020  |  Metallomics

A dysregulation in the homeostasis of metals such as copper, iron and zinc is speculated to be involved in the pathogenesis of tau..

Zinc Transporter-3 Knockout Mice Demonstrate Age-Dependent Alterations in the Metalloproteome.

Sara M Hancock, Stuart D Portbury, Adam P Gunn, Blaine R Roberts, Ashley I Bush, Paul A Adlard

Journal article  |  2020  |  International Journal of Molecular Sciences

Metals are critical cellular elements that are involved in a variety of cellular processes, with recent literature demonstrating t..

Characterising the brain metalloproteome in Down syndrome patients with concomitant Alzheimer's pathology

Nakisa Malakooti, Blaine Roberts, Melanie A Pritchard, Irene Volitakis, Ron C Kim, Ira T Lott, Catriona A McLean, David Finkelstein, Paul A Adlard

Journal article  |  2020  |  Metallomics

Down syndrome (DS) is a common intellectual disability, with an incidence of 1 in 700 and is caused by trisomy 21. People with DS ..

Brain Zinc Deficiency Exacerbates Cognitive Decline in the R6/1 Model of Huntington's Disease.

Scott Ayton, Peng Lei, Ambili T Appukuttan, Thibault Renoir, Simote Foliaki, Feng Chen, Paul A Adlard, Anthony J Hannan, Ashley I Bush

Journal article  |  2020  |  Neurotherapeutics

There is currently no disease-modifying treatment for Huntington's disease (HD), which is characterized by chorea motor impairment..

Preferential Neurodegeneration in the Dentate Gyrus by Amyloid β1-42-Induced Intracellular Zn2 Dysregulation and Its Defense Strategy.

Haruna Tamano, Mako Takiguchi, Yukino Tanaka, Taku Murakami, Paul A Adlard, Ashley I Bush, Atsushi Takeda

Journal article  |  2019  |  Molecular Neurobiology

On the basis of the evidence that rapid intracellular Zn2+ dysregulation by amyloid β1-42 (Aβ1-42) in the normal hippocampus trans..

Effects of exercise and environmental enrichment in serotonin transporter knock-out mice

J Rogers, F Chen, D Stanic, F Farzana, S Li, A Zeleznikow-Johnston, J Nithianantharajah, L Churilov, P Adlard, L Lanfumey, A Hannan, T Renoir

Conference Proceedings  |  2019  |  EUROPEAN NEUROPSYCHOPHARMACOLOGY

Paradoxical effects of exercise on hippocampal plasticity and cognition in mice with a heterozygous null mutation in the serotonin transporter gene

Jake Rogers, Feng Chen, Davor Stanic, Farheen Farzana, Shanshan Li, Ariel M Zeleznikow-Johnston, Jess Nithianantharajah, I Leonid Churilov, Paul A Adlard, Laurence Lanfumey, Anthony J Hannan, Thibault Renoir

Journal article  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

Evaluation of attention in APP/PS1 mice shows impulsive and compulsive behaviours

Amy Shepherd, Carlos May, Leonid Churilov, Paul A Adlard, Anthony J Hannan, Emma L Burrows

Journal article  |  2019  |  Genes, Brain and Behavior

While Alzheimer's disease (AD) is traditionally associated with deficits in episodic memory, early changes in other cognitive doma..

L-3,4-dihydroxyphenylalanine (L-DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson's disease

Jessica L Billings, Sarah L Gordon, Tristan Rawling, Philip A Doble, Ashley I Bush, Paul A Adlard, David I Finkelstein, Dominic J Hare

Journal article  |  2019  |  Journal of Neurochemistry

Amyloid beta(1-42)-Induced Rapid Zn2 Influx into Dentate Granule Cells Attenuates Maintained LTP Followed by Retrograde Amnesia

Haruna Tamano, Hiroki Suzuki, Taku Murakami, Hiroaki Fujii, Paul A Adlard, Ashley I Bush, Atsushi Takeda

Journal article  |  2019  |  Molecular Neurobiology

On the basis of the evidence that amyloid β1-42 (Aβ1-42)-induced Zn2+ influx affects memory acquisition via attenuated long-term p..

Extracellular Zn2 -independently attenuated LTP by human amyloid beta(1-40) and rat amyloid beta(1-42)

Haruna Tamano, Mako Takiguchi, Ryota Shimaya, Paul A Adlard, Ashley I Bush, Atsushi Takeda

Journal article  |  2019  |  Biochemical and Biophysical Research Communications

Difference in ability for extracellular Zn2 influx between human and rat amyloid beta(1-42) and its significance

Haruna Tamano, Hiroki Suzuki, Shuhei Kobuchi, Paul A Adlard, Ashley I Bush, Atsushi Takeda

Journal article  |  2019  |  NeuroToxicology

In vivo synaptic activity-independent co-uptakes of amyloid beta(1-42) and Zn2 into dentate granule cells in the normal brain

Haruna Tamano, Naoya Oneta, Aoi Shioya, Paul A Adlard, Ashley Bush, Atsushi Takeda

Journal article  |  2019  |  Scientific Reports

PBT434 Prevents alpha-synuclein Aggregation, Neuron Loss, Motor Dysfunction and Reduces Glial Cell Inclusions in a Transgenic Mouse Model of Multiple System Atrophy

David Finkelstein, Nadia Stefanova, Paul Adlard, Margaret Bradbury, David Stamler

Conference Proceedings  |  2019  |  NEUROLOGY

Early existence and biochemical evolution characterise acutely synaptotoxic PrPSc

Simote Totauhelotu Foliaki, Victoria Lewis, Abu Mohammed Taufiqual Islam, Laura Jane Ellett, Matteo Senesi, David Isaac Finkelstein, Blaine Roberts, Victoria A Lawson, Paul Anthony Adlard, Steven John Collins

Journal article  |  2019  |  PLOS Pathogens

On-line reverse isotope dilution analysis for spatial quantification of elemental labels used in immunohistochemical assisted imaging mass spectrometry via LA-ICP-MS

David Clases, Raquel Gonzalez de Vega, Paul A Adlard, Philip A Doble

Journal article  |  2019  |  Journal of Analytical Atomic Spectrometry

The Down Syndrome-Associated Protein, Regulator of Calcineurin-1, is Altered in Alzheimer's Disease and Dementia with Lewy Bodies

N Malakooti, C FOWLER, I Volitakis, CA McLean, RC Kim, Ashley Bush, A REMBACH, MA PRITCHARD, DI Finkelstein, PA Adlard

Journal article  |  2019  |  Journal of Alzheimer's disease & Parkinsonism

There is a known relationship between Alzheimer's disease (AD) and Down syndrome (DS), with the latter typically developing AD-lik..

Metal chaperones: a novel therapeutic strategy for brain injury?

SD Portbury, A Sedjahtera, K Perrones, C Sgambelloni, M Zhang, PJ Crack, DI Finkelstein, PA Adlard

Journal article  |  2019  |  Brain Injury

Ageing and Cognition.

Sydney MA Juan, Paul A Adlard

Journal article  |  2019  |  Sub-cellular biochemistry

With an increasingly ageing population that is expected to double by 2050 in the U.S., it is paramount that we further understand ..

Iron is increased in the brains of ageing mice lacking the neurofilament light gene.

James C Vickers, Anna E King, Graeme H McCormack, Aidan D Bindoff, Paul A Adlard

Journal article  |  2019  |  PLOS ONE

There has been strong interest in the role of metals in neurodegeneration, and how ageing may predispose the brain to related dise..

Zn-DTSM, A Zinc Ionophore with Therapeutic Potential for Acrodermatitis Enteropathica?

Lisa Bray, Irene Volitakis, Scott Ayton, Ashley I Bush, Paul A Adlard

Journal article  |  2019  |  Nutrients

The Involvement of Iron in Traumatic Brain Injury and Neurodegenerative Disease

Maria Daglas, Paul A Adlard

Journal article  |  2018  |  Frontiers in Neuroscience

Modulating Protein Phosphatase 2A Rescues Disease Phenotype in Neurodegenerative Tauopathies

Simon McKenzie-Nickson, Jacky Chan, Keyla Perez, Lin W Hung, Lesley Cheng, Amelia Sedjahtera, Lydia Gunawan, Paul A Adlard, David J Hayne, Lachlan E McInnes, Paul S Donnelly, David Finkelstein, Andrew F Hill, Kevin J Barnham

Journal article  |  2018  |  ACS Chemical Neuroscience

Adrenergic beta receptor activation in the basolateral amygdala, which is intracellular Zn2 -dependent, rescues amyloid beta(1-42)-induced attenuation of dentate gyrus LTP

Haruna Tamano, Mitsuyasu Kubota, Yuki Fujise, Ryota Shimaya, Ryusei Itoh, Miki Suzuki, Paul A Adlard, Ashley Bush, Atsushi Takeda

Journal article  |  2018  |  Neurochemistry International

Novel Defense by Metallothionein Induction Against Cognitive Decline: From Amyloid beta(1-42)-Induced Excess Zn2 to Functional Zn2 Deficiency

Atsushi Takeda, Haruna Tamano, Wakana Hashimoto, Shuhei Kobuchi, Hiroki Suzuki, Taku Murakami, Munekazu Tempaku, Yuta Koike, Paul A Adlard, Ashley I Bush

Journal article  |  2018  |  Molecular Neurobiology

Targeting metals rescues the phenotype in an animal model of tauopathy

Amelia Sedjahtera, Lydia Gunawan, Lisa Bray, Lin Wai Hung, Jack Parsons, Nobuyuki Okamura, Victor L Villemagne, Kazuhiko Yanai, Xiang M Liu, Jacky Chan, Ashley I Bush, David I Finkelstein, Kevin J Barnham, Robert A Cherny, Paul A Adlard

Journal article  |  2018  |  Metallomics

Untangling Tau and Iron: Exploring the Interaction Between Iron and Tau in Neurodegeneration

Shalini S Rao, Paul Anthony Adlard

Journal article  |  2018  |  Frontiers in Molecular Neuroscience

Altered Amygdala Excitation and CB1 Receptor Modulation of Aggressive Behavior in the Neuroligin-3(R451C) Mouse Model of Autism

Suzanne Hosie, Daniel T Malone, Stephanie Liu, Michelle Glass, Paul Anthony Adlard, Anthony John Hannan, Elisa L Hill-Yardin

Journal article  |  2018  |  Frontiers in Cellular Neuroscience

Prion acute synaptotoxicity is largely driven by protease-resistant PrPSc species

Simote Totauhelotu Foliaki, Victoria Lewis, David Isaac Finkelstein, Victoria Lawson, Harold Arthur Coleman, Matteo Senesi, Abu Mohammed Taufiqual Islam, Feng Chen, Shannon Sarros, Blaine Roberts, Paul Anthony Adlard, Steven John Collins

Journal article  |  2018  |  PLOS Pathogens

Trehalose elevates brain zinc levels following controlled cortical impact in a mouse model of traumatic brain injury

Stuart D Portbury, Dominic J Hare, David P Bishop, David I Finkelstein, Philip A Doble, Paul A Adlard

Journal article  |  2018  |  Metallomics

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

Shashank Masaldan, Sharnel AS Clatworthy, Cristina Gamell, Peter M Meggyesy, Antonia-Tonia Rigopoulos, Sue Haupt, Ygal Haupt, Delphine Denoyer, Paul A Adlard, Ashley I Bush, Michael A Cater

Journal article  |  2018  |  Redox Biology

Acute Neurotoxicity Models of Prion Disease

AMT Islam, PA Adlard, DI Finkelstein, V Lewis, S Biggi, E Biasini, SJ Collins

Journal article  |  2018  |  ACS Chemical Neuroscience

Metals and Alzheimer's Disease: How Far Have We Come in the Clinic?

Paul A Adlard, Ashley I Bush

Journal article  |  2018  |  Journal of Alzheimer's Disease

Zinc Signal in Brain Diseases

Stuart D Portbury, Paul A Adlard

Journal article  |  2017  |  International Journal of Molecular Sciences

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

Q-Z Tuo, P Lei, KA Jackman, X-I Li, H Xiong, X-L Li, Z-Y Liuyang, L Roisman, S-T Zhang, S Ayton, Q Wang, PJ Crouch, K Ganio, X-C Wang, L Pei, PA Adlard, Y-M Lu, R Cappai, J-Z Wang, R Liu, et al.

Journal article  |  2017  |  Molecular Psychiatry

Accelerated kindling epileptogenesis in Tg4510 tau transgenic mice, but not in tau knockout mice

Shijie Liu, Yu Shen, Sandy R Shultz, Nguyen Anne, Christopher Hovens, Paul A Adlard, Ashley I Bush, Jianxiong Chan, Patrick Kwan, Terence J O'Brien, Nigel C Jones

Journal article  |  2017  |  Epilepsia

Trehalose improves traumatic brain injury-induced cognitive impairment

Stuart D Portbury, Dominic J Hare, David I Finkelstein, Paul A Adlard

Journal article  |  2017  |  PLOS ONE

Extracellular Zn2 Is Essential for Amyloid beta(1-42)-Induced Cognitive Decline in the Normal Brain and Its Rescue

Atsushi Takeda, Haruna Tamano, Munekazu Tempaku, Miku Sasaki, Chihiro Uematsu, Shoko Sato, Hiroaki Kanazawa, Zsolt L Datki, Paul A Adlard, Ashley I Bush

Journal article  |  2017  |  The Journal of Neuroscience

In vivo prion models and the disconnection between transmissibility and neurotoxicity

Matteo Senesi, Victoria Lewis, Jee H Kim, Paul A Adlard, David I Finkelstein, Steven J Collins

Journal article  |  2017  |  Ageing Research Reviews

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease

David I Finkelstein, Jessica L Billings, Paul A Adlard, Scott Ayton, Amelia Sedjahtera, Colin L Masters, Simon Wilkins, David M Shackleford, Susan A Charman, Wojciech Bal, Izabela A Zawisza, Ewa Kurowska, Andrew L Gundlach, Sheri Ma, Ashley I Bush, Dominic J Hare, Philip A Doble, Simon Crawford, Elisabeth CL Gautier, Jack Parsons, et al.

Journal article  |  2017  |  Acta Neuropathologica Communications

Age modulates the injury-induced metallomic profile in the brain

Stuart D Portbury, Dominic J Hare, Charlotte J Sgambelloni, David P Bishop, David I Finkelstein, Philip A Doble, Paul A Adlard

Journal article  |  2017  |  Metallomics

Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion

Javier Castro-Hernandez, Paul A Adlard, David I Finkelstein

Journal article  |  2017  |  Scientific Reports

Iron, Copper, and Zinc Concentration in A beta Plaques in the APP/PS1 Mouse Model of Alzheimer's Disease Correlates with Metal Levels in the Surrounding Neuropil

Simon A James, Quentin I Churches, Martin D de Jonge, Ian E Birchall, Victor Streltsov, Gawain McColl, Paul A Adlard, Dominic J Hare

Journal article  |  2017  |  ACS Chemical Neuroscience

Ferroptosis and cell death mechanisms in Parkinson's disease

Stephanie J Guiney, Paul A Adlard, Ashley I Bush, David I Finkelstein, Scott Ayton

Journal article  |  2017  |  Neurochemistry International

Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer's Disease

Stuart D Portbury, Dominic J Hare, Charlotte Sgambelloni, Kali Perronnes, Ashley J Portbury, David I Finkelstein, Paul A Adlard

Journal article  |  2017  |  Journal of Alzheimer's Disease

Delivery of Fluorescent Nanoparticles to the Brain

Olga Shimoni, Bingyang Shi, Paul A Adlard, Ashley I Bush

Journal article  |  2016  |  Journal of Molecular Neuroscience

Involvement of hippocampal excitability in amyloid beta-induced behavioral and psychological symptoms of dementia

Haruna Tamano, Kazuki Ide, Paul Anthony Adlard, Ashley Ian Bush, Atsushi Takeda

Journal article  |  2016  |  The Journal of Toxicological Sciences

Effects of Neonatal Iron Feeding and Chronic Clioquinol Administration on the Parkinsonian Human A53T Transgenic Mouse

Jessica L Billings, Dominic J Hare, Milawaty Nurjono, Irene Volitakis, Robert A Cherny, Ashley I Bush, Paul A Adlard, David I Finkelstein

Journal article  |  2016  |  ACS Chemical Neuroscience

Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice

DI Finkelstein, DJ Hare, JL Billings, A Sedjahtera, M Nurjono, E Arthofer, S George, JG Culvenor, AI Bush, PA Adlard

Journal article  |  2016  |  ACS Chemical Neuroscience

A time-course analysis of changes in cerebral metal levels following a controlled cortical impact

Stuart D Portbury, Dominic J Hare, Charlotte Sgambelloni, David I Finkelstein, Paul A Adlard

Journal article  |  2016  |  Metallomics

Overexpression of Metallothionein-1 Modulates the Phenotype of the Tg2576 Mouse Model of Alzheimer's Disease

Yasmina Manso, Gemma Comes, Juan C Lopez-Ramos, Monica Belfiore, Amalia Molinero, Mercedes Giralt, Javier Carrasco, Paul A Adlard, Ashley I Bush, Jose Maria Delgado-Garcia, Juan Hidalgo

Journal article  |  2016  |  Journal of Alzheimer's Disease

Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice

David I Finkelstein, Dominic J Hare, Jessica L Billings, Amelia Sedjahtera, Milawaty Nurjono, Elisa Arthofer, Sonia George, Janetta G Culvenor, Ashley I Bush, Paul A Adlard

Journal article  |  2016  |  ACS chemical neuroscience

Iron Regulates Apolipoprotein E Expression and Secretion in Neurons and Astrocytes

He Xu, Victoria M Perreau, Krista A Dent, Ashley I Bush, David I Finkelstein, Paul A Adlard

Journal article  |  2016  |  Journal of Alzheimer's Disease

Loss of synaptic Zn2 transporter function increases risk of febrile seizures

Michael S Hildebrand, A Marie Phillips, Saul A Mullen, Paul A Adlard, Katia Hardies, John A Damiano, Verena Wimmer, Susannah T Bellows, Jacinta M McMahon, Rosemary Burgess, Rik Hendrickx, Sarah Weckhuysen, Arvid Suls, Peter De Jonghe, Ingrid E Scheffer, Steven Petrou, Samuel F Berkovic, Christopher A Reid

Journal article  |  2015  |  Scientific Reports

Novel zinc-targeted therapeutic options for cognitive decline

Stuart D Portbury, Luz Fernanda Yevenes, Paul A Adlard

Journal article  |  2015  |  Future Neurology

Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way

He Xu, Veer B Gupta, Ian J Martins, Ralph N Martins, Christopher J Fowler, Ashley I Bush, David I Finkelstein, Paul A Adlard

Journal article  |  2015  |  Neurobiology of Disease

Metal chaperones prevent zinc-mediated cognitive decline

Paul A Adlard, Jacqui Parncutt, Varsha Lal, Simon James, Dominic Hare, Philip Doble, David I Finkelstein, Ashley I Bush

Journal article  |  2015  |  Neurobiology of Disease

Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

Peng Lei, Scott Ayton, Ambili Thoppuvalappil Appukuttan, Irene Volitakis, Paul A Adlard, David I Finkelstein, Ashley I Bush

Journal article  |  2015  |  Neurobiology of Disease

Editorial: The molecular pathology of cognitive decline: focus on metals

Paul A Adlard, Roger S Chung

Journal article  |  2015  |  Frontiers in Aging Neuroscience

Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of beta-Amyloid Precursor Protein

Scott Ayton, Peng Lei, Dominic J Hare, James A Duce, Jessica L George, Paul A Adlard, Catriona McLean, Jack T Rogers, Robert A Cherny, David I Finkelstein, Ashley I Bush

Journal article  |  2015  |  Journal of Neuroscience

Stabilization of Nontoxic A beta-Oligomers: Insights into the Mechanism of Action of Hydroxyquinolines in Alzheimer's Disease

Timothy M Ryan, Blaine R Roberts, Gawain McColl, Dominic J Hare, Philip A Doble, Qiao-Xin Li, Monica Lind, Anne M Roberts, Haydyn DT Mertens, Nigel Kirby, Chi LL Pham, Mark G Hinds, Paul A Adlard, Kevin J Barnham, Cyril C Curtain, Colin L Masters

Journal article  |  2015  |  Journal of Neuroscience

Rhenium and technetium complexes that bind to amyloid-beta plaques

David J Hayne, Andrea J North, Michelle Fodero-Tavoletti, Jonathan M White, Lin W Hung, Angela Rigopoulos, Catriona A McLean, Paul A Adlard, Uwe Ackermann, Henri Tochon-Danguy, Victor L Villemagne, Kevin J Barnham, Paul S Donnelly

Journal article  |  2015  |  Dalton Transactions

Multivariate Autoregressive-based Neuronal Network Flow Analysis for In-vitro Recorded Bursts

Imali T Hettiarachchi, Asim Bhatti, Paul A Adlard, Saeid Nahavandi

Conference Proceedings  |  2015  |  Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Traumatic Brain Injury, Chronic Traumatic Encephalopathy, and Alzheimer's Disease: Common Pathologies Potentiated by Altered Zinc Homeostasis

Stuart D Portbury, Paul A Adlard

Journal article  |  2015  |  Journal of Alzheimer's Disease

Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging (vol 6, pg 5383, 2015)

Bence Paul, Dominic J Hare, David P Bishop, Chad Paton, Tran Nguyen Van, Nerida Cole, Megan M Niedzwiecki, Erica Andreozzi, Angela Vais, Jessica L Billings, Lisa Bray, Ashley I Bush, Gawain McColl, Blaine R Roberts, Paul A Adlard, David I Finkelstein, John Hellstrom, Janet M Hergt, Jon D Woodhead, Philip A Doble

Journal article  |  2015  |  Chemical Science

Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging

Bence Paul, Dominic J Hare, David P Bishop, Chad Paton, Tran Nguyen Van, Nerida Cole, Megan M Niedwiecki, Erica Andreozzi, Angela Vais, Jessica L Billings, Lisa Bray, Ashley I Bush, Gawain McColl, Blaine R Roberts, Paul A Adlard, David I Finkelstein, John Hellstrom, Janet M Hergt, Jon D Woodhead, Philip A Doble

Journal article  |  2015  |  Chemical Science

Amyloid beta-Mediated Zn2 Influx into Dentate Granule Cells Transiently Induces a Short-Term Cognitive Deficit

Atsushi Takeda, Masatoshi Nakamura, Hiroaki Fujii, Chihiro Uematsu, Tatsuya Minamino, Paul A Adlard, Ashley I Bush, Haruna Tamano

Journal article  |  2014  |  PLoS ONE

beta-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

Bruce X Wong, Andrew Tsatsanis, Linh Q Lim, Paul A Adlard, Ashley I Bush, James A Duce

Journal article  |  2014  |  PLoS ONE

A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe2 under physiologically relevant conditions

Bruce X Wong, Scott Ayton, Linh Q Lam, Peng Lei, Paul A Adlard, Ashley I Bush, James A Duce

Journal article  |  2014  |  Biochimica et Biophysica Acta (BBA) - General Subjects

Spatial memory deficits in a mouse model of late-onset Alzheimer's disease are caused by zinc supplementation and correlate with amyloid-beta levels

Jane M Flinn, P Lorenzo Bozzelli, Paul A Adlard, Angela M Railey

Journal article  |  2014  |  Frontiers in Aging Neuroscience

The clinical implications of impaired zinc signaling in the brain

SM Hancock, AI Bush, PA Adlard

Book Chapter  |  2014

beta-amyloid in biological samples: not all A beta detection methods are created equal

Paul A Adlard, Qiao-Xin Li, Catriona McLean, Colin L Masters, Ashley I Bush, Michelle Fodero-Tavoletti, Victor Villemagne, Kevin J Barnham

Journal article  |  2014  |  Frontiers in Aging Neuroscience

Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease

Scott Ayton, Peng Lei, Paul A Adlard, Irene Volitakis, Robert A Cherny, Ashley I Bush, David I Finkelstein

Journal article  |  2014  |  Molecular Neurodegeneration

Glia and zinc in ageing and Alzheimer's disease: a mechanism for cognitive decline?

Sara M Hancock, David I Finkelstein, Paul A Adlard

Journal article  |  2014  |  Frontiers in Aging Neuroscience

Role of metal ions in the cognitive decline of Down syndrome

Nakisa Malakooti, Melanie A Pritchard, Paul A Adlard, David I Finkelstein

Journal article  |  2014  |  Frontiers in Aging Neuroscience

Interactions of metals and Apolipoprotein E in Alzheimer's disease

He Xu, David I Finkelstein, Paul A Adlard

Journal article  |  2014  |  Frontiers in Aging Neuroscience

A novel approach to rapidly prevent age-related cognitive decline

Paul A Adlard, Amelia Sedjahtera, Lydia Gunawan, Lisa Bray, Dominic Hare, Jessica Lear, Philip Doble, Ashley I Bush, David I Finkelstein, Robert A Cherny

Journal article  |  2014  |  Aging Cell

The effect of paraformaldehyde fixation and sucrose cryoprotection on metal concentration in murine neurological tissue

Dominic J Hare, Jessica L George, Lisa Bray, Irene Volitakis, Angela Vais, Timothy M Ryan, Robert A Cherny, Ashley I Bush, Colin L Masters, Paul A Adlard, Philip A Doble, David I Finkelstein

Journal article  |  2014  |  Journal of Analytical Atomic Spectrometry

A review of β-amyloid neuroimaging in Alzheimer's disease

PA Adlard, BA Tran, DI Finkelstein, PM Desmond, LA Johnston, AI Bush, GF Egan

Journal article  |  2014  |  Frontiers in Neuroscience

Alzheimer's disease (AD) is the most common cause of dementia worldwide. As advancing age is the greatest risk factor for developi..

An iron-dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta

Dominic J Hare, Peng Lei, Scott Ayton, Blaine R Roberts, Rudolf Grimm, Jessica L George, David P Bishop, Alison D Beavis, Sarah J Donovan, Gawain McColl, Irene Volitakis, Colin L Masters, Paul A Adlard, Robert A Cherny, Ashley I Bush, David I Finkelstein, Philip A Doble

Journal article  |  2014  |  Chemical Science

Clioquinol Synergistically Augments Rescue by Zinc Supplementation in a Mouse Model of Acrodermatitis Enteropathica

Jim Geiser, Robert C De Lisle, David Finkelstein, Paul A Adlard, Ashley I Bush, Glen K Andrews

Journal article  |  2013  |  PLoS One

Altered Expression of ZnT10 in Alzheimer's Disease Brain

Helen J Bosomworth, Paul A Adlard, Dianne Ford, Ruth A Valentine

Journal article  |  2013  |  PLoS One

The effect of dopamine on MPTP-induced rotarod disability

Scott Ayton, Jessica L George, Paul A Adlard, Ashley I Bush, Robert A Cherny, David I Finkelstein

Journal article  |  2013  |  Neuroscience Letters

Intravenous Immunglobulin Binds Beta Amyloid and Modifies Its Aggregation, Neurotoxicity and Microglial Phagocytosis In Vitro

Susann Cattepoel, Alexander Schaub, Miriam Ender, Annette Gaida, Alain Kropf, Ursula Guggisberg, Marc W Nolte, Louis Fabri, Paul A Adlard, David I Finkelstein, Reinhard Bolli, Sylvia M Miescher

Journal article  |  2013  |  PLoS One

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

Scott Ayton, Peng Lei, James A Duce, Bruce XW Wong, Amelia Sedjahtera, Paul A Adlard, Ashley I Bush, David I Finkelstein

Journal article  |  2013  |  Annals of Neurology

Metallobiology of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity

Dominic J Hare, Paul A Adlard, Philip A Doble, David I Finkelstein

Journal article  |  2013  |  Metallomics: integrated biometal science

Development of a Platinum Complex as an anti-Amyloid Agent for the Therapy of Alzheimer's Disease

Vijaya B Kenche, Lin W Hung, Keyla Perez, Irene Volitakes, Guiseppe Ciccotosto, Jeffrey Kwok, Nicole Critch, Nikki Sherratt, Mikhalina Cortes, Varsha Lal, Colin L Masters, Kazuma Murakami, Roberto Cappai, Paul A Adlard, Kevin J Barnham

Journal article  |  2013  |  Angewandte Chemie - International Edition

Zinc in Alzheimer's and Parkinson's Diseases

S AYTON, DI Finkelstein, RA Cherny, AI Bush, PA Adlard

Book Chapter  |  2013

Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease

Yasmina Manso, Javier Carrasco, Gemma Comes, Paul A Adlard, Ashley I Bush, Juan Hidalgo

Journal article  |  2012  |  Cellular and Molecular Life Sciences

Characterization of the role of metallothionein-3 in an animal model of Alzheimer's disease

Yasmina Manso, Javier Carrasco, Gemma Comes, Gabriele Meloni, Paul A Adlard, Ashley I Bush, Milan Vasak, Juan Hidalgo

Journal article  |  2012  |  Cellular and Molecular Life Sciences

Redox-active Cu(II)-A beta causes substantial changes in axonal integrity in cultured cortical neurons in an oxidative-stress dependent manner

Claire Howells, Katrina Saar, Emma Eaton, Shannon Ray, Peep Palumaa, Lana Shabala, Paul A Adlard, William Bennett, Adrian K West, Gilles J Guillemin, Roger S Chung

Journal article  |  2012  |  Experimental Neurology

High-Resolution Elemental Bioimaging of Ca, Mn, Fe, Co, Cu, and Zn Employing LA-ICP-MS and Hydrogen Reaction Gas

Jessica Lear, Dominic J Hare, Fred Fryer, Paul A Adlard, David I Finkelstein, Philip A Doble

Journal article  |  2012  |  Analytical Chemistry

Three-Dimensional Atlas of Iron, Copper, and Zinc in the Mouse Cerebrum and Brainstem

Dominic J Hare, Jason K Lee, Alison D Beavis, Amanda van Gramberg, Jessica George, Paul A Adlard, David I Finkelstein, Philip A Doble

Journal article  |  2012  |  Analytical Chemistry

Metal chaperones: a holistic approach to the treatment of Alzheimer's disease.

Paul Anthony Adlard, Ashley Ian Bush

Journal article  |  2012  |  Frontiers in Psychiatry

As evidence for the role of metal ion dysregulation in the pathogenesis of multiple CNS disorders grows, it has become important t..

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

Peng Lei, Scott Ayton, David I Finkelstein, Loredana Spoerri, Giuseppe D Ciccotosto, David K Wright, Bruce XW Wong, Paul A Adlard, Robert A Cherny, Linh Q Lam, Blaine R Roberts, Irene Volitakis, Gary F Egan, Catriona A McLean, Roberto Cappai, James A Duce, Ashley I Bush

Journal article  |  2012  |  Nature Medicine

Elevated labile Cu is associated with oxidative pathology in Alzheimer disease

Simon A James, Irene Volitakis, Paul A Adlard, James A Duce, Colin L Masters, Robert A Cherny, Ashley I Bush

Journal article  |  2012  |  Free Radical Biology and Medicine

Improving acquisition times of elemental bio-imaging for quadrupole-based LA-ICP-MS

Jessica Lear, Dominc Hare, Paul Adlard, David Finkelstein, Philip Doble

Journal article  |  2012  |  Journal of Analytical Atomic Spectrometry

Metallothionein and brain inflammation

Yasmina Manso, Paul A Adlard, Javier Carrasco, Milan Vasak, Juan Hidalgo

Journal article  |  2011  |  JBIC Journal of Biological Inorganic Chemistry

Corrigendum to 'Mild stress facilitates learning and exercise improves retention in aged mice' [Experimental Gerontology 46/1 (2011) page 53-59]

PA Adlard, C Engesser-Cesar, CW Cotman

Journal article  |  2011  |  Experimental Gerontology

The Alzheimer's therapeutic PBT2 promotes amyloid-beta degradation and GSK3 phosphorylation via a metal chaperone activity

Peter J Crouch, Maria S Savva, Lin W Hung, Paul S Donnelly, Alexandra I Mot, Sarah J Parker, Mark A Greenough, Irene Volitakis, Paul A Adlard, Robert A Cherny, Colin L Masters, Ashley I Bush, Kevin J Barnham, Anthony R White

Journal article  |  2011  |  Journal of Neurochemistry

Role of amyloid-β-metal interactions in Alzheimers disease

JA Duce, AI Bush, PA Adlard

Journal article  |  2011  |  Future Neurology

Tg2576 Cortical Neurons That Express Human Ab Are Susceptible to Extracellular A beta-Induced, K Efflux Dependent Neurodegeneration

Shannon Ray, Claire Howells, Emma D Eaton, Chris W Butler, Lana Shabala, Paul A Adlard, Adrian K West, William R Bennett, Gilles J Guillemin, Roger S Chung

Journal article  |  2011  |  PLoS ONE

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease.

Michelle T Fodero-Tavoletti, Nobuyuki Okamura, Shozo Furumoto, Rachel S Mulligan, Andrea R Connor, Catriona A McLean, Diana Cao, Angela Rigopoulos, Glenn A Cartwright, Graeme O'Keefe, Sylvia Gong, Paul A Adlard, Kevin J Barnham, Christopher C Rowe, Colin L Masters, Yukitsuka Kudo, Roberto Cappai, Kazuhiko Yanai, Victor L Villemagne

Journal article  |  2011  |  Brain

While considerable effort has focused on developing positron emission tomography β-amyloid imaging radiotracers for the early diag..

F-18-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

Michelle T Fodero-Tavoletti, Nobuyuki Okamura, Shozo Furumoto, Rachel S Mulligan, Andrea R Connor, Catriona A McLean, Diana Cao, Angela Rigopoulos, Glenn A Cartwright, Graeme O'Keefe, Sylvia Gong, Paul A Adlard, Kevin J Barnham, Christopher C Rowe, Colin L Masters, Yukitsuka Kudo, Roberto Cappai, Kazuhiko Yanai, Victor L Villemagne

Journal article  |  2011  |  Brain

Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

Paul A Adlard, Laura Bica, Anthony R White, Milawaty Nurjono, Gulay Filiz, Peter J Crouch, Paul S Donnelly, Roberto Cappai, David I Finkelstein, Ashley I Bush

Journal article  |  2011  |  PLoS One

The plasma membrane redox system in Alzheimer's disease

PA Adlard, AI Bush

Journal article  |  2011  |  Experimental Neurology

Mild stress facilitates learning and exercise improves retention in aged mice

Paul A Adlard, Christie Engesser-Cesar, Carl W Cotman

Journal article  |  2011  |  Experimental Gerontology

GSK-3 in Neurodegenerative Diseases.

Peng Lei, Scott Ayton, Ashley I Bush, Paul A Adlard

Journal article  |  2011  |  International Journal of Alzheimer's Disease

Glycogen synthase kinase-3 (GSK-3) regulates multiple cellular processes, and its dysregulation is implicated in the pathogenesis ..

Copper modulation as a therapy for Alzheimer's disease?

Yasmina Manso, Gemma Comes, Juan Hidalgo, Ashley I Bush, Paul A Adlard

Journal article  |  2011  |  International Journal of Alzheimer's Disease

The role of metals in the pathophysiology of Alzheimer's disease (AD) has gained considerable support in recent years, with both i..

Tau protein: Relevance to Parkinson's disease

Peng Lei, Scott Ayton, David I Finkelstein, Paul A Adlard, Colin L Masters, Ashley I Bush

Journal article  |  2010  |  International Journal of Biochemistry and Cell Biology

Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

Paul A Adlard, Jacqui M Parncutt, David I Finkelstein, Ashley I Bush

Journal article  |  2010  |  Journal of Neuroscience

Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain

Dominic J Hare, Jessica L George, Rudolph Grimm, Simon Wilkins, Paul A Adlard, Robert A Cherny, Ashley I Bush, David I Finkelstein, Philip Doble

Journal article  |  2010  |  Metallomics: integrated biometal science

Zinc and copper modulate Alzheimer A beta levels in human cerebrospinal fluid

Dorothea Strozyk, Lenore J Launer, Paul A Adlard, Robert A Cherny, Andrew Tsatsanis, Irene Volitakis, Kai Blennow, Helen Petrovitch, Lon R White, Ashley I Bush

Journal article  |  2009  |  Neurobiology of Aging

Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging

Adele Woodhouse, James C Vickers, Paul A Adlard, Tracey C Dickson

Journal article  |  2009  |  Neurobiology of Aging

beta-AMYLOID AS A MOLECULAR THERAPEUTIC TARGET IN ALZHEIMER'S DISEASE

Paul A Adlard, Simon A James, Ashley I Bush, Colin L Masters

Journal article  |  2009  |  Drugs of today (Barcelona, Spain : 1998)

Increasing Cu bioavailability inhibits A beta oligomers and tau phosphorylation

Peter J Crouch, Lin Wai Hung, Paul A Adlard, Mikhalina Cortes, Varsha Lal, Gulay Filiz, Keyla A Perez, Milawaty Nurjono, Aphrodite Caragounis, Tai Du, Katrina Laughton, Irene Volitakis, Ashley I Bush, Qiao-Xin Li, Colin L Masters, Roberto Cappai, Robert A Cherny, Paul S Donnelly, Anthony R White, Kevin J Barnham

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

ß-amyloid as a molecular therapeutic target in Alzheimer's disease

P ADLARD, S JAMES, A BUSH, C MASTERS

Journal article  |  2009  |  Drugs of Today

The Effects of Enhanced Zinc on Spatial Memory and Plaque Formation in Transgenic Mice

David H Linkous, Paul A Adlard, Patricia B Wanschura, Kathryn M Conko, Jane M Flinn

Journal article  |  2009  |  Journal of Alzheimer's Disease

Pharmacotherapeutic targets in Alzheimer's disease

Yif'at Biran, Colin L Masters, Kevin J Barnham, Ashley I Bush, Paul A Adlard

Journal article  |  2009  |  Journal of Cellular and Molecular Medicine

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial A beta

Paul A Adlard, Robert A Cherny, David I Finkelstein, Elisabeth Gautier, Elysia Robb, Mikhalina Cortes, Irene Volitakis, Xiang Liu, Jeffrey P Smith, Keyla Perez, Katrina Laughton, Qiao-Xin Li, Susan A Charman, Joseph A Nicolazzo, Simon Wilkins, Karolina Deleva, Toni Lynch, Gaik Kok, Craig W Ritchie, Rudolph E Tanzi, et al.

Journal article  |  2008  |  Neuron

Metal ions and Alzheimer's disease

PA Adlard, AI Bush

Book Chapter  |  2007

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau

Simon Melov, Paul A Adlard, Karl Morten, Felicity Johnson, Tamara R Golden, Doug Hinerfeld, Birgit Schilling, Christine Mavros, Colin L Masters, Irene Volitakis, Qiao-Xin Li, Katrina Laughton, Alan Hubbard, Robert A Cherny, Brad Gibson, Ashley I Bush

Journal article  |  2007  |  PLoS One

Metallothionein-I and -III expression in animal models of Alzheimer disease

J Carrasco, P Adlard, C Cotman, A Quintana, M Penkowa, F Xu, WE Van Nostrand, J Hidalgo

Journal article  |  2006  |  Neuroscience

Metals and Alzheimer's disease

Paul A Adlard, Ashley I Bush

Journal article  |  2006  |  Journal of Alzheimer's Disease

Metals and Alzheimer's disease

PA Adlard, AI Bush

Journal article  |  2006  |  Journal of Alzheimer's Disease

Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease

PA Adlard, VM Perreau, V Pop, CW Cotman

Journal article  |  2005  |  Journal of Neuroscience

The exercise-induced expression of BDNF within the hippocampus varies across life-span

PA Adlard, VM Perreau, CW Cotman

Journal article  |  2005  |  Neurobiology of Aging

Chronic immobilization stress differentially affects the expression of BDNF mRNA and protein in the mouse hippocampus

PA Adlard, VM Perreau, CW Cotman

Journal article  |  2004  |  Stress and Health

Alzheimer's disease--a sum greater than its parts?

Paul A Adlard, Brian J Cummings

Journal article  |  2004  |  Neurobiology of Aging

The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise

PA Adlard, VM Perreau, C Engesser-Cesar, CW Cotman

Journal article  |  2004  |  Neuroscience Letters

Exercise-induced gene expression changes in the rat spinal cord

VM Perreau, PA Adlard, AJ Anderson, CW Cotman

Journal article  |  2004  |  Gene Expression

Neuron-glia communication: metallothionein expression is specifically up-regulated by astrocytes in response to neuronal injury.

Roger S Chung, Paul A Adlard, Justin Dittmann, James C Vickers, Meng Inn Chuah, Adrian K West

Journal article  |  2004  |  Journal of Neurochemistry

Recent data suggests that metallothioneins (MTs) are major neuroprotective proteins within the CNS. In this regard, we have recent..

Voluntary exercise protects against stress-induced decreases in brain-derived neurotrophic factor protein expression.

PA Adlard, CW Cotman

Journal article  |  2004  |  Neuroscience

Exercise is increasingly recognized as an intervention that can reduce CNS dysfunctions such as cognitive decline, depression and ..

Morphologically distinct plaque types differentially affect dendritic structure and organisation in the early and late stages of Alzheimer's disease.

Paul A Adlard, James C Vickers

Journal article  |  2002  |  Acta Neuropathologica

We have investigated the effects of the deposition of insoluble beta-amyloid plaques on dendritic morphology within the neocortex...

Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus.

NC Berchtold, JP Kesslak, CJ Pike, PA Adlard, CW Cotman

Journal article  |  2001  |  European Journal of Neuroscience

We investigated the possibility that estrogen and exercise interact in the hippocampus and regulate brain-derived neurotrophic fac..

Sequence of cellular changes following localized axotomy to cortical neurons in glia-free culture.

TC Dickson, PA Adlard, JC Vickers

Journal article  |  2000  |  Journal of Neurotrauma

This study utilizes an in vitro model of localized physical injury to axons to examine the specific responses of neocortical neuro..

The effects of taxol on the central nervous system response to physical injury.

PA Adlard, CE King, JC Vickers

Journal article  |  2000  |  Acta Neuropathologica

Cytoskeletal disruption is a key pathological change in numerous human neurodegenerative diseases. We have, therefore, examined th..

Neuronal response to physical injury and its relationship to the pathology of Alzheimer's disease.

CE King, PA Adlard, TC Dickson, JC Vickers

Conference Proceedings  |  2000  |  Clinical and Experimental Pharmacology and Physiology

1. Central nerve cells undergo a stereotyped regenerative response following physical injury. 2. This reaction involves adaptive c..

The cause of neuronal degeneration in Alzheimer's disease.

JC Vickers, TC Dickson, PA Adlard, HL Saunders, CE King, G McCormack

Journal article  |  2000  |  Progress in Neurobiology

Alzheimer's disease is associated with a specific pattern of pathological changes in the brain that result in neurodegeneration an..

Increased density of metallothionein I/II-immunopositive cortical glial cells in the early stages of Alzheimer's disease.

PA Adlard, AK West, JC Vickers

Journal article  |  1998  |  Neurobiology of Disease

We have examined the possible role of metallothionein I/II (MT I/II) in Alzheimer's disease (AD), with a focus on the cellular loc..

Pseudomonas aeruginosa as a cause of infectious diarrhoea.

PA Adlard, SM Kirov, K Sanderson, GE Cox

Journal article  |  1998  |  Epidemiology and Infection

Pseudomonas aeruginosa is not generally considered a cause of infectious diarrhoea. However, it was the predominant organism isola..