Christopher O'Callaghan

Effect of Salt Supplementation on Sympathetic Activity and Endothelial Function in Salt-Sensitive Type 2 Diabetes

Sara Baqar, Yee Wen Kong, Angela X Chen, Christopher O'Callaghan, Richard J MacIsaac, Maree Bouterakos, Gavin W Lambert, George Jerums, Elisabeth E Lambert, Elif Ekinci

Journal article  |  2020  |  The Journal of Clinical Endocrinology & Metabolism

CONTEXT: Lower sodium intake is paradoxically associated with higher mortality in type 2 diabetes (T2D). OBJECTIVE: To determine w..

Effect of angiotensin II receptor blocker and salt supplementation on short-term blood pressure variability in type 2 diabetes

Angela X Chen, John L Moran, Renata Libianto, Sara Baqar, Christopher O'Callaghan, Richard J MacIsaac, George Jerums, Elif Ekinci

Journal article  |  2020  |  Journal of Human Hypertension

High blood pressure variability (BPV) has been associated with increased cardiovascular (CV) risk. The effect of dietary salt and ..

Inosine pranobex enhances human NK cell cytotoxicity by inducing metabolic activation and NKG2D ligand expression.

Michael T McCarthy, Da Lin, Tomoyoshi Soga, Julie Adam, Christopher A O'Callaghan

Journal article  |  2020  |  European Journal of Immunology

Inosine pranobex (IP) is a synthetic immunomodulating compound, indicated for use in the treatment of human papillomavirus-associa..

Effects of antihypertensives, lipid-modifying drugs, glycaemic control drugs and sodium bicarbonate on the progression of stages 3 and 4 chronic kidney disease in adults: a systematic review and meta-analysis.

Kathryn S Taylor, Julie Mclellan, Jan Y Verbakel, Jeffrey K Aronson, Daniel S Lasserson, Nicola Pidduck, Nia Roberts, Susannah Fleming, Christopher A O'Callaghan, Clare R Bankhead, Amitava Banerjee, Fd Richard Hobbs, Rafael Perera

Journal article  |  2019  |  BMJ Open

OBJECTIVE: To evaluate the effects of drug interventions that may modify the progression of chronic kidney disease (CKD) in adults..

Trends in kidney function testing in UK primary care since the introduction of the quality and outcomes framework: a retrospective cohort study using CPRD.

Benjamin Feakins, Jason Oke, Emily McFadden, Jeffrey Aronson, Daniel Lasserson, Christopher O'Callaghan, Clare Taylor, Nathan Hill, Richard Stevens, Rafael Perera

Journal article  |  2019  |  BMJ Open

OBJECTIVES: To characterise serum creatinine and urinary protein testing in UK general practices from 2005 to 2013 and to examine ..

Outcomes of Older Patients (≥ 70 Years) Treated With Targeted Therapy in Metastatic Chemorefractory Colorectal Cancer: Retrospective Analysis of NCIC CTG CO.17 and CO.20

JC Wells, D Tu, LL Siu, JD Shapiro, DJ Jonker, C Karapetis, J Simes, G Liu, TJ Price, NC Tebbutt, CJ O'Callaghan

Journal article  |  2019  |  Clinical Colorectal Cancer

Expanded RAS and BRAF V600 testing as predictive biomarkers for single agent cetuximab in the randomized phase III CO.17 trial.

Jonathan M Loree, Anthony Dowers, Dongsheng Tu, Christopher J O'Callaghan, Dan Edelstein, Hannah Quinn, Derek J Jonker, Chris Karapetis, Timothy Jay Price, John Raymond Zalcberg, Malcolm J Moore, Paul Michael Waring, Hagen F Kennecke, Stanley R Hamilton, Scott Kopetz

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Reduced kidney function at presentation in unselected acute emergency medical admissions: incidence, outcome and associated factors.

E Yang, A Chalisey, ME Reschen, B Shine, DS Lasserson, CA O'Callaghan

Journal article  |  2019  |  Acute Medicine

We sought to assess the impact of renal impairment on acute medical admissions and to identify potential contributory factors to a..

Comparison of diurnal blood pressure and urine production between people with and without chronic spinal cord injury

Min Yin Goh, Melinda S Millard, Edmund CK Wong, David J Berlowitz, Marnie Graco, Rachel M Schembri, Douglas J Brown, Albert G Frauman, Christopher J O'Callaghan

Journal article  |  2018  |  Spinal Cord

Napabucasin versus placebo in refractory advanced colorectal cancer: a randomised phase 3 trial

Derek J Jonker, Louise Nott, Takayuki Yoshino, Sharlene Gill, Jeremy Shapiro, Atsushi Ohtsu, John Zalcberg, Michael M Vickers, Alice C Wei, Yuan Gao, Niall C Tebbutt, Ben Markman, Timothy Price, Taito Esaki, Sheryl Koski, Matthew Hitron, Wei Li, Youzhi Li, Nadine M Magoski, Chiang J Li, et al.

Journal article  |  2018  |  The Lancet Gastroenterology & Hepatology

Relationship between urinary sodium-to-potassium ratio and ambulatory blood pressure in patients with diabetes mellitus

Renata Libianto, John Moran, Christopher O'Callaghan, Sara Baqar, Angela X Chen, Scott T Baker, Michelle Clarke, Richard J MacIsaac, George Jerums, Elif I Ekinci

Journal article  |  2018  |  Clinical and Experimental Pharmacology and Physiology

Relationship between autonomic cardiovascular control and obstructive sleep apnoea in persons with spinal cord injury: a retrospective study.

Xizhe Fang, Min Yin Goh, Christopher O'Callaghan, David Berlowitz

Journal article  |  2018  |  Spinal Cord Series and Cases

Study design: Retrospective study. Objective: To determine if there is an association between obstructive sleep apnoea (OSA) and b..

Does left ventricular hypertrophy affect cognition and brain structural integrity in type 2 diabetes? Study design and rationale of the Diabetes and Dementia (D2) study

Sheila K Patel, Carolina Restrepo, Emilio Werden, Leonid Churilov, Elif I Ekinci, Piyush M Srivastava, Jay Ramchand, Bryan Wai, Brian Chambers, Christopher J O'Callaghan, David Darby, Vladimir Hachinski, Toby Cumming, Geoff Donnan, Louise M Burrell, Amy Brodtmann

Journal article  |  2017  |  BMC ENDOCRINE DISORDERS

Diurnal blood pressure and urine production in acute spinal cord injury compared with controls

MY Goh, MS Millard, ECK Wong, DJ Brown, AG Frauman, CJ O'Callaghan

Journal article  |  2017  |  Spinal Cord

Hypertension as a predictor of outcome and treatment response to cetuximab: A retrospective analysis of NCIC CTG CO.17.

Shelly Sud, Christopher J O'Callaghan, Caleb Jonker, Christos Stelios Karapetis, Timothy Jay Price, Niall C Tebbutt, Jeremy David Shapiro, Guy A Van Hazel, Nick Pavlakis, Peter Gibbs, Mark Jeffery, Lillian L Siu, Sharlene Gill, Ralph Wong, Derek J Jonker, Dongsheng Tu, Rachel Anne Goodwin

Conference Proceedings  |  2016  |  Journal of Clinical Oncology

Short-term dietary salt supplementation blunts telmisartan induced increases in plasma renin activity in hypertensive patients with type 2 diabetes mellitus

Angela X Chen, George Jerums, Sara Baqar, Elisabeth Lambert, Goji Somarajah, Georgina Thomas, Christopher O'Callaghan, Richard J MacIsaac, Elif I Ekinci

Journal article  |  2015  |  Clinical Science

Response to 'A retrospective review of sleep disordered breathing, hypertension and cardiovascular diseases in spinal cord injury patients'

MY Goh, ECK Wong, MS Millard, DJ Brown, DJ Berlowitz, CJ O'Callaghan

Journal article  |  2015  |  Spinal Cord

A retrospective review of the ambulatory blood pressure patterns and diurnal urine production in subgroups of spinal cord injured patients

MY Goh, ECK Wong, MS Millard, DJ Brown, CJ O'Callaghan

Journal article  |  2015  |  Spinal Cord

National guidelines for the management of absolute cardiovascular disease risk

Christopher J O'Callaghan, Pei Rong, Min Y Goh

Journal article  |  2014  |  Medical Journal of Australia

Does Abnormal Circadian Blood Pressure Pattern Really Matter in Patients With Transient Ischemic Attack or Minor Stroke?

WenWen Zhang, Dominique A Cadilhac, Leonid Churilov, Geoffrey A Donnan, Christopher O'Callaghan, Helen M Dewey

Journal article  |  2014  |  Stroke

Audit of co-management and critical care outreach for high risk postoperative patients (The POST audit)

DA Story, A Shelton, D Jones, M Heland, R Bellomo

Journal article  |  2013  |  Anaesthesia and Intensive Care

Hypertension The difficult decisions

Christopher James O'Callaghan, Min Yin Goh, Pei Rong

Journal article  |  2013  |  Australian Family Physician

Autosomal dominant vasovagal syncope Clinical features and linkage to chromosome 15q26

Karl Martin Klein, Catherine J Bromhead, Katherine R Smith, Christopher J O'Callaghan, Susan J Corcoran, Sarah E Heron, Xenia Iona, Bree L Hodgson, Jacinta M McMahon, Kate M Lawrence, Ingrid E Scheffer, Leanne M Dibbens, Melanie Bahlo, Samuel F Berkovic

Journal article  |  2013  |  Neurology

Salt supplementation blunts the blood pressure response to telmisartan with or without hydrochlorothiazide in hypertensive patients with type 2 diabetes

EI Ekinci, G Thomas, RJ MacIsaac, C Johnson, C Houlihan, S Panagiotopoulos, E Premaratne, H Hao, S Finch, C O'Callaghan, G Jerums

Journal article  |  2010  |  Diabetologia

Effects of Salt Supplementation on the Albuminuric Response to Telmisartan With or Without Hydrochlorothiazide Therapy in Hypertensive Patients With Type 2 Diabetes Are Modulated by Habitual Dietary Salt Intake

Elif I Ekinci, Georgina Thomas, David Thomas, Cameron Johnson, Richard J MacIsaac, Christine A Houlihan, Sue Finch, Sianna Panagiotopoulos, Chris O'Callaghan, George Jerums

Journal article  |  2009  |  Diabetes Care

Hypertension and TIA

WW Zhang, DA Cadilhac, GA Donnan, C O'Callaghan, HM Dewey

Journal article  |  2009  |  International Journal of Stroke

Famllial hyperaldosteronism type 1 in pregnancy

E Hamilton, C O'Callaghan, RM O'Brien, M Stowasser, R Gordon, J Zajac, M Grossmann

Journal article  |  2009  |  Internal Medicine Journal

The regulation of human vascular smooth muscle extracellular matrix protein production by alpha- and beta-adrenoceptor stimulation

CJ O'Callaghan, B Williams

Journal article  |  2002  |  Journal of Hypertension

Erratum: Effects of insulin and glucocorticoids on the leptin system are mediated through free leptin (Clinical Endocrinology (537))

K Lewandowski, HS Randeva, CJ O'Callaghan, R Horn, GF Medley, EW Hillhouse, G Brabant, P O'Hare

Journal article  |  2001  |  Clinical Endocrinology

Renal artery stenosis: a disease worth pursuing

SC Parker, A Hannah, M Brooks, WJ Louis, CJ O'Callaghan

Journal article  |  2001  |  Medical Journal of Australia

Improved outcomes in stroke thrombolysis with pre-specified imaging criteria.

B Silver, B Demaerschalk, JG Merino, E Wong, A Tamayo, A Devasenapathy, C O'Callaghan, A Kertesz, GB Young, AJ Fox, JD Spence, V Hachinski

Journal article  |  2001  |  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

BACKGROUND: A 1995 National Institute of Neurological Disorders (NINDS) study found benefit for intravenous tissue plasminogen act..

Impact of a toxicology service on a metropolitan teaching hospital.

V Lee, JF Kerr, G Braitberg, WJ Louis, CJ O'Callaghan, AG Frauman, ML Mashford

Journal article  |  2001  |  Emergency Medicine

OBJECTIVE: To evaluate the impact of a toxicology service on a major metropolitan teaching hospital. METHOD: A descriptive compara..

Low-dose ramipril reduces microalbuminuria in type 1 diabetic patients without hypertension: results of a randomized controlled trial.

P O'Hare, R Bilbous, T Mitchell, CJ O' Callaghan, GC Viberti, undefined Ace-Inhibitor Trial to Lower Albuminuria in Normotensive Insulin-Dependent Subjects Study Group

Journal article  |  2000  |  Diabetes Care

OBJECTIVE: To assess if low (1.25 mg) and/or standard (5 mg) doses of the ACE inhibitor ramipril could prevent progression of micr..

Mechanical strain-induced extracellular matrix production by human vascular smooth muscle cells: role of TGF-beta(1).

CJ O'Callaghan, B Williams

Journal article  |  2000  |  Hypertension

Elevated blood pressure imposes increased mechanical stress on the vascular wall, and mechanical strain is a mitogenic stimulus fo..

Hypoxia-induced vascular endothelial growth factor expression is potentiated by elevated glucose levels.

M Meier, CJ O'Callaghan, B Gallacher, E Standl, B Williams

Journal article  |  2000  |  Diabetic Medicine

Use of computerized neuropsychological tests (CANTAB) to assess cognitive effects of antihypertensive drugs in the elderly. Cambridge Neuropsychological Test Automated Battery.

WJ Louis, AG Mander, M Dawson, C O'Callaghan, EL Conway

Conference Proceedings  |  1999  |  Journal of Hypertension

OBJECTIVE: To establish reliability and ease of use of the Cambridge Neuropsychological Test Automated Battery (CANTAB) in assessi..

Hypotensive effect of low-fat, high-carbohydrate diet can be independent of changes in plasma insulin concentrations.

NE Straznicky, CJ O'Callaghan, VE Barrington, WJ Louis

Journal article  |  1999  |  Hypertension

To examine the relationship between diet, blood pressure, and plasma insulin concentrations, we studied 14 healthy males who were ..

Systematic errors in estimating mean blood pressure from finger blood pressure measurements.

CJ O'Callaghan, NE Straznicky, K Komersova, WJ Louis

Journal article  |  1998  |  Blood Pressure

The mean blood pressure (BP) can be accurately estimated from indirect measurements of brachial artery pressure, i.e. mean BP = di..

Is hyperinsulinaemia during withdrawal of ethanol due to an increase in secretion of insulin or a decrease in clearance of insulin?

CJ O'Callaghan, WJ Louis

Journal article  |  1998  |  Journal of Hypertension

Acute effects of blood pressure elevation on insulin clearance in normotensive healthy subjects.

CJ O'Callaghan, K Komersova, WJ Louis

Journal article  |  1998  |  Hypertension

Reduced clearance of insulin from plasma contributes to the hyperinsulinemia associated with essential hypertension (EH); however,..

'Physiological' hyperinsulinaemia increases distal artery systolic blood pressure without changing proximal blood pressure.

CJ O'Callaghan, K Komersova, H Krum, WJ Louis

Journal article  |  1997  |  Clinical Science

1. Although epidemiological data links essential hypertension with insulin resistance, 'physiological' insulin concentrations have..

Essential hypertension and insulin clearance and resistance.

C O'Callaghan

Journal article  |  1997  |  Hypertension

6.1 Adrenergic stimulation increases extracellular matrix production by human vascular smooth muscle cells

CJ O’Callaghan, B Williams

Conference Proceedings  |  1997  |  Journal of Hypertension

Lidocaine pharmacokinetics after cardiac arrest and external cardiopulmonary resuscitation.

J Hendrie, CJ O'Callaghan

Journal article  |  1996  |  The American Journal of Cardiology

Although prolonged cardiopulmonary resuscitation may impair drug metabolism, plasma lidocaine concentrations tended to remain with..

Insulin as a pressor agent: effects of 'physiological' insulin concentrations on finger blood pressure.

CJ O'Callaghan, K Komersova, WJ Louis

Conference Proceedings  |  1996  |  Blood Pressure, Supplement

Epidemiological evidence has linked essential hypertension with impaired tissue sensitivity to insulin (i.e. insulin resistance) a..

Total norepinephrine spillover, muscle sympathetic nerve activity and heart-rate spectral analysis in a patient with dopamine beta-hydroxylase deficiency.

JM Thompson, CJ O'Callaghan, BA Kingwell, GW Lambert, GL Jennings, MD Esler

Journal article  |  1995  |  Journal of the Autonomic Nervous System

Dopamine-beta-hydroxylase (D beta H) is the enzyme responsible for intraneural conversion of dopamine to norepinephrine. Its defic..

Diabetes and hypertension. Australian Diabetes Society position statement.

RE Gilbert, M Jasik, M DeLuise, CJ O'Callaghan, ME Cooper

Journal article  |  1995  |  Medical Journal of Australia

Efficacy of pravastatin in combination with captopril in hypertensive patients.

CJ O'Callaghan, H Krum, EL Conway, W Lam, MA Skiba, LG Howes, WJ Louis

Journal article  |  1995  |  Medical Journal of Australia

OBJECTIVE: To determine the efficacy of pravastatin in the treatment of primary hypercholesterolaemia in patients being treated wi..

Short term effects of pravastatin on blood pressure in hypercholesterolaemic hypertensive patients.

CJ O'Callaghan, H Krum, EL Conway, W Lam, MA Skiba, LG Howes, WJ Louis

Journal article  |  1994  |  Blood Pressure

In this study, which was primarily designed to determine the lipid-lowering efficacy of pravastatin in the setting of background a..

Pharmaceutical Benefits Scheme.

WJ Louis, CJ O'Callaghan, H Krum, AG Mander, ES Louis

Journal article  |  1994  |  Medical Journal of Australia

RAPIDLY DEVELOPING PSEUDOHYPERTENSION AFTER RENAL-TRANSPLANTATION DIAGNOSED BY NON-AUSCULTATED BLOOD-PRESSURE MEASUREMENT

CJ OCALLAGHAN, WJ LOUIS, GK HART, G JACKMAN, LG HOWES, P MIACH

Journal article  |  1994  |  Nephron

A single-dose comparison of the bioavailability of aluminium from two formulations of sucralphate in normal volunteers.

EL Conway, C O'Callaghan, OH Drummer, LG Howes, WJ Louis

Journal article  |  1994  |  Biopharmaceutics & Drug Disposition

The oral bioavailability of aluminium was compared after administration of 1 g sucralphate as either a tablet or a suspension (1 g..

Pharmaceutical Benefits Scheme (PBS)

WJ Louis, CJ O'Callaghan, H Krum, AG Mander, ES Louis

Journal article  |  1994  |  Medical Journal of Australia

Neonatal platelet reactivity and serum thromboxane B2 production in whole blood: the effect of maternal low dose aspirin.

KA Louden, F Broughton Pipkin, S Heptinstall, SC Fox, P Tuohy, C O'Callaghan, JR Mitchell, EM Symonds

Journal article  |  1994  |  BJOG: An International Journal of Obstetrics and Gynaecology

OBJECTIVES: Concern has been expressed about possible neonatal side effects after the use of maternal anti-platelet agents in preg..

Pharmacokinetics of prilocaine in intravenous regional anaesthesia

J SMYTH, J HENDRIE, N BERLINSKI, C O'CALLAGHAN, W LOUIS

Journal article  |  1994  |  Emergency Medicine

Pharmacokinetics of prilocaine in intravenous regional anaesthesia

J Hendrie, J Smythe, N Berlinski, C O'Callaghan, W Louis

Journal article  |  1994  |  Emergency Medicine

Relevance of pharmacokinetic differences between ACE inhibitors and their role in the treatment of hypertension.

WJ Louis, EL Conway, CJ O'Callaghan, ES Louis, O Drummer, JJ McNeil, LG Howes, H Krum

Journal article  |  1993  |  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

A randomized placebo-controlled study of the effect of low dose aspirin on platelet reactivity and serum thromboxane B2 production in non-pregnant women, in normal pregnancy, and in gestational hypertension.

KA Louden, F Broughton Pipkin, EM Symonds, P Tuohy, C O'Callaghan, S Heptinstall, S Fox, JR Mitchell

Journal article  |  1992  |  BJOG: An International Journal of Obstetrics and Gynaecology

OBJECTIVE: To investigate the effect of 60 mg aspirin daily on platelet reactivity and prostaglandin production in various groups ..

Cardiac risk factor management. Experience of an outpatient hypertension clinic.

NE Straznicky, LG Howes, H Krum, CJ O'Callaghan, JJ McNeil, PA Phillips, B Jackson, SN Anavekar, K Jandeleit, JC Hurley

Journal article  |  1991  |  Medical Journal of Australia

OBJECTIVE: To describe the outcome of the management of cardiovascular risk factors in the hypertension clinic of a teaching hospi..

Potassium and magnesium in essential hypertension.

C O'Callaghan, L Howes

Journal article  |  1990  |  BMJ

Can the rapid semiquantitative estimation of serum C reactive protein be adapted for the management of bacterial infection?

NP Richards, TS Elliott, RJ Powell, C O'Callaghan, P Franklin

Journal article  |  1985  |  Journal of Clinical Pathology

Serum C reactive protein concentrations measured by a laboratory based assay were compared with the semiquantitative results obtai..

C reactive protein concentrations in neonates: determination by a latex enhanced immunoassay.

C O'Callaghan, P Franklin, TS Elliott, I Deverill, N Richards, RJ Powell

Journal article  |  1984  |  Journal of Clinical Pathology

A latex enhanced immunoassay on a centrifugal fast analyser was used to compare serum C reactive protein concentrations in materna..