Christopher O'Callaghan

Effect of Salt Supplementation on Sympathetic Activity and Endothelial Function in Salt-Sensitive Type 2 Diabetes

Sara Baqar, Yee Wen Kong, Angela X Chen, Christopher O'Callaghan, Richard J MacIsaac, Maree Bouterakos, Gavin W Lambert, George Jerums, Elisabeth E Lambert, Elif Ekinci

Journal article  |  2020  |  The Journal of Clinical Endocrinology & Metabolism

CONTEXT: Lower sodium intake is paradoxically associated with higher mortality in type 2 diabetes (T2D). OBJECTIVE: To determine w..

Effect of angiotensin II receptor blocker and salt supplementation on short-term blood pressure variability in type 2 diabetes

Angela X Chen, John L Moran, Renata Libianto, Sara Baqar, Christopher O'Callaghan, Richard J MacIsaac, George Jerums, Elif Ekinci

Journal article  |  2020  |  Journal of Human Hypertension

High blood pressure variability (BPV) has been associated with increased cardiovascular (CV) risk. The effect of dietary salt and ..

Outcomes of Older Patients (≥ 70 Years) Treated With Targeted Therapy in Metastatic Chemorefractory Colorectal Cancer: Retrospective Analysis of NCIC CTG CO.17 and CO.20

JC Wells, D Tu, LL Siu, JD Shapiro, DJ Jonker, C Karapetis, J Simes, G Liu, TJ Price, NC Tebbutt, CJ O'Callaghan

Journal article  |  2019  |  Clinical Colorectal Cancer

Background: The safety and efficacy of targeted therapy in older patients (≥ 70 years) with metastatic colorectal cancer is not we..

Expanded RAS and BRAF V600 testing as predictive biomarkers for single agent cetuximab in the randomized phase III CO.17 trial.

Jonathan M Loree, Anthony Dowers, Dongsheng Tu, Christopher J O'Callaghan, Dan Edelstein, Hannah Quinn, Derek J Jonker, Chris Karapetis, Timothy Jay Price, John Raymond Zalcberg, Malcolm J Moore, Paul Michael Waring, Hagen F Kennecke, Stanley R Hamilton, Scott Kopetz

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

537 Background: KRAS/NRAS ( RAS) testing of exons 2, 3 and 4 is standard prior to anti-EGFR treatment in metastatic colorectal ca..

Comparison of diurnal blood pressure and urine production between people with and without chronic spinal cord injury

Min Yin Goh, Melinda S Millard, Edmund CK Wong, David J Berlowitz, Marnie Graco, Rachel M Schembri, Douglas J Brown, Albert G Frauman, Christopher J O'Callaghan

Journal article  |  2018  |  Spinal Cord

STUDY DESIGN: Observational study. OBJECTIVES: To quantify diurnal blood pressure (BP) patterns and nocturnal hypertension and to ..

Napabucasin versus placebo in refractory advanced colorectal cancer: a randomised phase 3 trial

Derek J Jonker, Louise Nott, Takayuki Yoshino, Sharlene Gill, Jeremy Shapiro, Atsushi Ohtsu, John Zalcberg, Michael M Vickers, Alice C Wei, Yuan Gao, Niall C Tebbutt, Ben Markman, Timothy Price, Taito Esaki, Sheryl Koski, Matthew Hitron, Wei Li, Youzhi Li, Nadine M Magoski, Chiang J Li, et al.

Journal article  |  2018  |  The Lancet Gastroenterology & Hepatology

BACKGROUND: Napabucasin is a first-in-class cancer stemness inhibitor that targets STAT3, which is a poor prognostic factor in col..

Relationship between urinary sodium-to-potassium ratio and ambulatory blood pressure in patients with diabetes mellitus

Renata Libianto, John Moran, Christopher O'Callaghan, Sara Baqar, Angela X Chen, Scott T Baker, Michelle Clarke, Richard J MacIsaac, George Jerums, Elif I Ekinci

Journal article  |  2018  |  Clinical and Experimental Pharmacology and Physiology

Previous studies investigating the relationship between sodium intake and blood pressure have mostly relied on dietary recall and ..

Relationship between autonomic cardiovascular control and obstructive sleep apnoea in persons with spinal cord injury: a retrospective study.

Xizhe Fang, Min Yin Goh, Christopher O'Callaghan, David Berlowitz

Journal article  |  2018  |  Spinal Cord Series and Cases

Study design: Retrospective study. Objective: To determine if there is an association between obstructive sleep apnoea (OSA) and b..

Does left ventricular hypertrophy affect cognition and brain structural integrity in type 2 diabetes? Study design and rationale of the Diabetes and Dementia (D2) study

Sheila K Patel, Carolina Restrepo, Emilio Werden, Leonid Churilov, Elif I Ekinci, Piyush M Srivastava, Jay Ramchand, Bryan Wai, Brian Chambers, Christopher J O'Callaghan, David Darby, Vladimir Hachinski, Toby Cumming, Geoff Donnan, Louise M Burrell, Amy Brodtmann

Journal article  |  2017  |  BMC ENDOCRINE DISORDERS

BACKGROUND: Cognitive impairment is common in type 2 diabetes mellitus, and there is a strong association between type 2 diabetes ..

Diurnal blood pressure and urine production in acute spinal cord injury compared with controls

MY Goh, MS Millard, ECK Wong, DJ Brown, AG Frauman, CJ O'Callaghan

Journal article  |  2017  |  Spinal Cord

STUDY DESIGN: This is a prospective observational study. OBJECTIVES: The objective of this study was to determine time-dependent c..