Kieran Harvey

The Hippo Pathway as a Driver of Select Human Cancers

Aishwarya Kulkarni, Matthew T Chang, Joseph HA Vissers, Anwesha Dey, Kieran F Harvey

Journal article  |  2020  |  Trends in Cancer

The Hippo pathway regulates myriad biological processes in diverse species and is a key cancer signaling network in humans. Althou..

The Hippo pathway in melanoma.

Xiaomeng Zhang, Lie Yang, Ismael Vergara, Pacman Szeto, Youfang Zhang, Anthony Papenfuss, Mark Shackleton, Kieran Harvey

Conference Proceedings  |  2020  |  MOLECULAR CANCER RESEARCH

The TAZ-CAMTA1 and YAP-TFE3 fusion proteins transform cells by binding to subunits of the histone acetyltransferase Ada2a-containing complex (ATAC).

Nicole Merritt, Keith Garcia, Dushyandi Rajendran, Zhen-Yuan Lin, Xiaomeng Zhang, Katrina Mitchell, Colleen Fullenkamp, Anne-Claude Gingras, Kieran Harvey, Munir Tanas

Conference Proceedings  |  2020  |  MOLECULAR CANCER RESEARCH

Evaluating YAP and TAZ as therapeutic targets for treating malignant mesothelioma with Hippo pathway disruptions.

Aishwarya S Kulkarni, Joseph HA Vissers, Kieran F Harvey

Conference Proceedings  |  2020  |  MOLECULAR CANCER RESEARCH

The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis

Xiaomeng Zhang, Lie Yang, Pacman Szeto, Gamze Kuser Abali, Youfang Zhang, Aishwarya Kulkarni, Kaushalya Amarasinghe, Jason Li, Ismael A Vergara, Ramyar Molania, Anthony T Papenfuss, Catriona McLean, Mark Shackleton, Kieran F Harvey

Journal article  |  2020  |  Oncogene

Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi

Joseph HA Vissers, Lucas G Dent, Colin M House, Shu Kondo, Kieran F Harvey

Journal article  |  2020  |  Genetics

The Hippo pathway is an evolutionary conserved signalling network that regulates organ size, cell fate control and tumorigenesis. ..

The regulation of Yorkie, YAP and TAZ: new insights into the Hippo pathway

Samuel A Manning, Benjamin Kroeger, Kieran F Harvey

Journal article  |  2020  |  Development

The Hippo pathway is a highly conserved signalling pathway that regulates multiple biological processes, including organ size cont..

Conserved Tao Kinase Activity Regulates Dendritic Arborization, Cytoskeletal Dynamics, and Sensory Function in Drosophila

Chun Hu, Alexandros K Kanellopoulos, Melanie Richter, Meike Petersen, Anja Konietzny, Federico M Tenedini, Nina Hoyer, Lin Cheng, Carole LC Poon, Kieran F Harvey, Sabine Windhorst, Jay Z Parrish, Marina Mikhaylova, Claudia Bagni, Froylan Calderon de Anda, Peter Soba

Journal article  |  2020  |  Journal of Neuroscience

Somatic Hypermutation of the YAP Oncogene in a Human Cutaneous Melanoma

Xiaomeng Zhang, Jian Zhong Tang, Ismael A Vergara, Youfang Zhang, Pacman Szeto, Lie Yang, Christopher Mintoff, Andrew Colebatch, Lachlan McIntosh, Katrina A Mitchell, Evangeline Shaw, Helen Rizos, Georgina Long, Nicholas Hayward, Grant A McArthur, Anthony T Papenfuss, Kieran F Harvey, Mark Shackleton

Journal article  |  2019  |  Molecular Cancer Research

The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development

Lucas G Dent, Samuel A Manning, Benjamin Kroeger, Audrey M Williams, Abdul Jabbar Saiful Hilmi, Luke Crea, Shu Kondo, Sally Horne-Badovinac, Kieran F Harvey

Journal article  |  2019  |  PLoS Genetics