Kieran Harvey

The Hippo Pathway as a Driver of Select Human Cancers.

Aishwarya Kulkarni, Matthew T Chang, Joseph HA Vissers, Anwesha Dey, Kieran F Harvey

Journal article  |  2020  |  Trends in Cancer

The Hippo pathway regulates myriad biological processes in diverse species and is a key cancer signaling network in humans. Althou..

Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi

Joseph HA Vissers, Lucas G Dent, Colin M House, Shu Kondo, Kieran F Harvey

Journal article  |  2020  |  Genetics

The Hippo pathway is an evolutionary conserved signalling network that regulates organ size, cell fate control and tumorigenesis. ..

The regulation of Yorkie, YAP and TAZ: new insights into the Hippo pathway

Samuel A Manning, Benjamin Kroeger, Kieran F Harvey

Journal article  |  2020  |  Development

The Hippo pathway is a highly conserved signalling pathway that regulates multiple biological processes, including organ size cont..

Conserved Tao Kinase Activity Regulates Dendritic Arborization, Cytoskeletal Dynamics, and Sensory Function in Drosophila

Chun Hu, Alexandros K Kanellopoulos, Melanie Richter, Meike Petersen, Anja Konietzny, Federico M Tenedini, Nina Hoyer, Lin Cheng, Carole LC Poon, Kieran F Harvey, Sabine Windhorst, Jay Z Parrish, Marina Mikhaylova, Claudia Bagni, Froylan Calderon de Anda, Peter Soba

Journal article  |  2020  |  The Journal of Neuroscience

Somatic Hypermutation of the YAP Oncogene in a Human Cutaneous Melanoma

Xiaomeng Zhang, Jian Zhong Tang, Ismael A Vergara, Youfang Zhang, Pacman Szeto, Lie Yang, Christopher Mintoff, Andrew Colebatch, Lachlan McIntosh, Katrina A Mitchell, Evangeline Shaw, Helen Rizos, Georgina Long, Nicholas Hayward, Grant A McArthur, Anthony T Papenfuss, Kieran F Harvey, Mark Shackleton

Journal article  |  2019  |  Molecular Cancer Research

The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development

Lucas G Dent, Samuel A Manning, Benjamin Kroeger, Audrey M Williams, Abdul Jabbar Saiful Hilmi, Luke Crea, Shu Kondo, Sally Horne-Badovinac, Kieran F Harvey

Journal article  |  2019  |  PLOS Genetics

A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster

Carole LC Poon, Weijie Liu, Yanjun Song, Marta Gomez, Yavuz Kulaberoglu, Xiaomeng Zhang, Wenjian Xu, Alexey Veraksa, Alexander Hergovich, Amin Ghabrial, Kieran F Harvey

Journal article  |  2018  |  Developmental Cell

The Scalloped and Nerfin-1 Transcription Factors Cooperate to Maintain Neuronal Cell Fate

Joseph HA Vissers, Francesca Froldi, Jan Schroder, Anthony T Papenfuss, Louise Y Cheng, Kieran F Harvey

Journal article  |  2018  |  CELL REPORTS

Elucidating the oncogenic mechanism of the TAZ-CAMTA1 and YAP-TFE3 fusion proteins

Nicole Merritt, Dushyandi Rajendran, Zhen-Yuan Lin, Xiaomeng Zhang, Katrina Mitchell, Colleen Fullenkamp, Anne-Claude Gingras, Kieran Harvey, Munir Tanas

Conference Proceedings  |  2018  |  Molecular and Cellular Biology / Genetics

Dynamic Fluctuations in Subcellular Localization of the Hippo Pathway Effector Yorkie In Vivo

Samuel A Manning, Lucas G Dent, Shu Kondo, Ziqing W Zhao, Nicolas Plachta, Kieran F Harvey

Journal article  |  2018  |  Current Biology

Regulation of Tissue Growth by the Mammalian Hippo Signaling Pathway

Kevin I Watt, Kieran F Harvey, Paul Gregorevic

Journal article  |  2017  |  FRONTIERS IN PHYSIOLOGY

Hippo Wades into Cancer Immunology

Thomas Gebhardt, Kieran F Harvey

Journal article  |  2016  |  Developmental Cell

Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua

Liu Yang, Sayantanee Paul, Kenneth G Trieu, Lucas G Dent, Francesca Froldi, Marta Fores, Kaitlyn Webster, Kellee R Siegfried, Shu Kondo, Kieran Harvey, Louise Cheng, Gerardo Jimenez, Stanislav Y Shvartsman, Alexey Veraksa

Journal article  |  2016  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo Pathway Regulates Neuroblasts and Brain Size in Drosophila melanogaster

Carole LC Poon, Katrina A Mitchell, Shu Kondo, Louise Y Cheng, Kieran F Harvey

Journal article  |  2016  |  Current Biology

A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth

Joseph HA Vissers, Samuel A Manning, Aishwarya Kulkarni, Kieran F Harvey

Journal article  |  2016  |  NATURE COMMUNICATIONS

Warts Opens Up for Activation

Samuel A Manning, Kieran F Harvey

Journal article  |  2015  |  Developmental Cell

Control of Organ Growth by Patterning and Hippo Signaling in Drosophila

Kenneth D Irvine, Kieran F Harvey

Journal article  |  2015  |  Cold Spring Harbor Perspectives in Biology

Growth Control: Re-examining Zyxin's Role in the Hippo Pathway

Kieran F Harvey

Journal article  |  2015  |  Current Biology

The GTPase Regulatory Proteins Pix and Git Control Tissue Growth via the Hippo Pathway

Lucas G Dent, Carole LC Poon, Xiaomeng Zhang, Joffrey L Degoutin, Marla Tipping, Alexey Veraksa, Kieran F Harvey

Journal article  |  2015  |  Current Biology

The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size

KI Watt, BJ Turner, A Hagg, X Zhang, JR Davey, H Qian, C Beyer, CE Winbanks, KF Harvey, P Gregorevic

Journal article  |  2015  |  Nature Communications

The Hippo Pathway Regulates Hematopoiesis in Drosophila melanogaster

Claire C Milton, Felix A Grusche, Joffrey L Degoutin, Eefang Yu, Qi Dai, Eric C Lai, Kieran F Harvey

Journal article  |  2014  |  Current Biology

Riquiqui and Minibrain are regulators of the Hippo pathway downstream of Dachsous

Joffrey L Degoutin, Claire C Milton, Eefang Yu, Marla Tipping, Floris Bosveld, Liu Yang, Yohanns Bellaiche, Alexey Veraksa, Kieran F Harvey

Journal article  |  2013  |  Nature Cell Biology

Yap Controls Stem/Progenitor Cell Proliferation in the Mouse Postnatal Epidermis

Annemiek Beverdam, Christina Claxton, Xiaomeng Zhang, Gregory James, Kieran F Harvey, Brian Key

Journal article  |  2013  |  Journal of Investigative Dermatology

The Hippo pathway and human cancer

Kieran F Harvey, Xiaomeng Zhang, David M Thomas

Journal article  |  2013  |  Nature Reviews Cancer

The Hippo Size Control Pathway-Ever Expanding

Jane I Lin, Carole LC Poon, Kieran F Harvey

Journal article  |  2013  |  Science Signaling

Homeodomain-Interacting Protein Kinase Regulates Hippo Pathway-Dependent Tissue Growth

Carole LC Poon, Xiaomeng Zhang, Jane I Lin, Samuel A Manning, Kieran F Harvey

Journal article  |  2012  |  Current Biology

The Hippo pathway-From top to bottom and everything in between

Nicolas Tapon, Kieran F Harvey

Journal article  |  2012  |  Seminars in Cell & Developmental Biology

The Hippo Pathway

Kieran F Harvey, Iswar K Hariharan

Journal article  |  2012  |  Cold Spring Harbor Perspectives in Biology

Control of Tissue Growth and Cell Transformation by the Salvador/Warts/Hippo Pathway

Xiaomeng Zhang, Felix A Grusche, Kieran F Harvey

Journal article  |  2012  |  PLoS One

Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP

L Angus, S Moleirinho, L Herron, A Sinha, X Zhang, M Niestrata, K Dholakia, MB Prystowsky, KF Harvey, PA Reynolds, FJ Gunn-Moore

Journal article  |  2012  |  Oncogene

The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway

Carole LC Poon, Jane I Lin, Xiaomeng Zhang, Kieran F Harvey

Journal article  |  2011  |  Developmental Cell

Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway

X Zhang, CC Milton, CLC Poon, W Hong, KF Harvey

Journal article  |  2011  |  Cell Death & Differentiation

The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene

X Zhang, J George, S Deb, JL Degoutin, EA Takano, SB Fox, DDL Bowtell, KF Harvey

Journal article  |  2011  |  Oncogene

The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster

Felix A Grusche, Joffrey L Degoutin, Helena E Richardson, Kieran F Harvey

Journal article  |  2011  |  Developmental Biology

WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ

SW Chan, CJ Lim, C Huang, YF Chong, HJ Gunaratne, KA Hogue, WP Blackstock, KF Harvey, W Hong

Journal article  |  2011  |  Oncogene

Modularity in the Hippo signaling pathway

Marius Sudol, Kieran F Harvey

Journal article  |  2010  |  Trends in Biochemical Sciences

Upstream Regulation of the Hippo Size Control Pathway

Felix A Grusche, Helena E Richardson, Kieran F Harvey

Journal article  |  2010  |  Current Biology

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

Nicola A Grzeschik, Linda M Parsons, Melinda L Allott, Kieran F Harvey, Helena E Richardson

Journal article  |  2010  |  Current Biology

Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster

Claire C Milton, Xiaomeng Zhang, Nathaniel O Albanese, Kieran F Harvey

Journal article  |  2010  |  Development

Bunched and Madm: a novel growth-regulatory complex?

Kieran F Harvey

Journal article  |  2010  |  Journal of Biology

By combining Drosophila genetics and proteomics Gluderer et al. report in this issue of Journal of Biology the isolation of a nove..

A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling

Anne-Kathrin Classen, Brandon D Bunker, Kieran F Harvey, Thomas Vaccari, David Bilder

Journal article  |  2009  |  Nature Genetics

Transcriptional Output of the Salvador/Warts/Hippo Pathway Is Controlled in Distinct Fashions in Drosophila melanogaster and Mammalian Cell Lines

Xiaomeng Zhang, Claire C Milton, Patrick O Humbert, Kieran F Harvey

Journal article  |  2009  |  Cancer Research

Making brundlefly, one gene at a time

Xiaomeng Zhang, Helena E Richardson, Kieran F Harvey

Journal article  |  2009  |  Cell Research

FOXO-regulated transcription restricts overgrowth of Tsc mutant organs

Kieran F Harvey, Jaakko Mattila, Avi Sofer, F Christian Bennett, Matthew R Ramsey, Leif W Ellisen, Oscar Puig, Iswar K Hariharan

Journal article  |  2008  |  Journal of Cell Biology

The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel

KF Harvey, A Dinudom, DI Cook, S Kumar

Journal article  |  2001  |  Journal of Biological Chemistry