Kieran Harvey

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Stephin J Vervoort, Sarah A Welsh, Jennifer R Devlin, Elisa Barbieri, Deborah A Knight, Sarah Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J Kearney, Jarrod J Sandow, Zheng Fan, Benjamin Blyth, Victoria McLeod, Joseph HA Vissers, Karolina Pavic, Ben P Martin, Gareth Gregory, Elena Demosthenous, Magnus Zethoven, et al.

Journal article  |  2021  |  CELL

Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent kinases (CDKs) at discrete checkpoints dur..

Crumbs and the apical spectrin cytoskeleton regulate r8 cell fate in the Drosophila eye

Jonathan M Pojer, Abdul Jabbar Saiful Hilmi, Shu Kondo, Kieran F Harvey

Journal article  |  2021  |  PLOS GENETICS

The Hippo pathway is an important regulator of organ growth and cell fate. In the R8 photoreceptor cells of the Drosophila melanog..

TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex

Nicole Merritt, Keith Garcia, Dushyandi Rajendran, Zhen-Yuan Lin, Xiaomeng Zhang, Katrina A Mitchell, Nicholas Borcherding, Colleen Fullenkamp, Michael S Chimenti, Anne-Claude Gingras, Kieran F Harvey, Munir R Tanas

Journal article  |  2021  |  ELIFE

Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma that metastasizes early in its clinical course and lacks an effective..

The Hippo Pathway as a Driver of Select Human Cancers

Aishwarya Kulkarni, Matthew T Chang, Joseph HA Vissers, Anwesha Dey, Kieran F Harvey

Journal article  |  2020  |  TRENDS IN CANCER

The Hippo pathway regulates myriad biological processes in diverse species and is a key cancer signaling network in humans. Althou..

The Hippo pathway in melanoma.

Xiaomeng Zhang, Lie Yang, Ismael Vergara, Pacman Szeto, Youfang Zhang, Anthony Papenfuss, Mark Shackleton, Kieran Harvey

Conference Proceedings  |  2020  |  MOLECULAR CANCER RESEARCH

The TAZ-CAMTA1 and YAP-TFE3 fusion proteins transform cells by binding to subunits of the histone acetyltransferase Ada2a-containing complex (ATAC).

Nicole Merritt, Keith Garcia, Dushyandi Rajendran, Zhen-Yuan Lin, Xiaomeng Zhang, Katrina Mitchell, Colleen Fullenkamp, Anne-Claude Gingras, Kieran Harvey, Munir Tanas

Conference Proceedings  |  2020  |  MOLECULAR CANCER RESEARCH

Evaluating YAP and TAZ as therapeutic targets for treating malignant mesothelioma with Hippo pathway disruptions.

Aishwarya S Kulkarni, Joseph HA Vissers, Kieran F Harvey

Conference Proceedings  |  2020  |  MOLECULAR CANCER RESEARCH

A PP2A-Integrator complex fine-tunes transcription by opposing CDK9

Stephin Vervoort, Sarah Welsh, Jennifer Devlin, Elisa Barbieri, Deborah Knight, Matteo Costacurta, Izabela Todorovski, Conor Kearney, Jarrod Sandow, Stefan Bjelosevic, Zheng Fan, Joep Vissers, Karolina Pavic, Ben Martin, Gareth Gregory, Isabella Kong, Edwin Hawkins, Simon Hogg, Madison Kelly, Andrea Newbold, et al.

Journal article  |  2020

SUMMARY Gene expression is tightly controlled by Cyclin-dependent kinases (CDKs) which regulate the RNA Polymerase II (RNAPII) tra..

The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis

Xiaomeng Zhang, Lie Yang, Pacman Szeto, Gamze Kuser Abali, Youfang Zhang, Aishwarya Kulkarni, Kaushalya Amarasinghe, Jason Li, Ismael A Vergara, Ramyar Molania, Anthony T Papenfuss, Catriona McLean, Mark Shackleton, Kieran F Harvey

Journal article  |  2020  |  ONCOGENE

Melanoma is a deadly form of skin cancer that accounts for a disproportionally large proportion of cancer-related deaths in younge..

The Hippo pathway in melanoma

Xiaomeng Zhang, Lie Yang, Ismael Vergara, Pacman Szeto, Youfang Zhang, Anthony Papenfuss, Mark Shackleton, Kieran Harvey

Conference Proceedings  |  2020  |  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION