Richard Gilbert

Diabetic kidney disease 2.0: the treatment paradigm shifts

Richard E Gilbert

Journal article  |  2019  |  The Lancet Diabetes & Endocrinology

Tubular protection with empagliflozin treatment in subjects with type 2 diabetes and cardiovascular disease: a sub-analysis of the EMPA-HEART CardioLink-6 trial

E Opingari, S Verma, CD Mazer, KA Connelly, AT Yan, F Zuo, T Mason, B Chowdhury, Y Pan, A Quan, H Teoh, LA Leiter, B Zinman, DZI Cherney, RE Gilbert

Conference Proceedings  |  2019  |  DIABETOLOGIA

Acute kidney injury with sodium-glucose co-transporter-2 inhibitors: A meta-analysis of cardiovascular outcome trials

Richard E Gilbert, Kevin E Thorpe

Journal article  |  2019  |  Diabetes, Obesity and Metabolism

Sirtuin 1 activation attenuates cardiac fibrosis in a rodent pressure overloadmodel by modifying Smad2/3 transactivation

Antoinette Bugyei-Twum, Christopher Ford, Robert Civitarese, Jessica Seegobin, Suzanne L Advani, Jean-Francois Desjardins, Golam Kabir, Yanling Zhang, Melissa Mitchell, Jennifer Switzer, Kerri Thai, Vanessa Shen, Armin Abadeh, Krishna K Singh, Filio Billia, Andrew Advani, Richard E Gilbert, Kim A Connelly

Journal article  |  2018  |  Cardiovascular Research

Hypertension Canada's 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children

Kara A Nerenberg, Kelly B Zarnke, Alexander A Leung, Kaberi Dasgupta, Sonia Butalia, Kerry McBrien, Kevin C Harris, Meranda Nakhla, Lyne Cloutier, Mark Gelfer, Maxime Lamarre-Cliche, Alain Milot, Peter Bolli, Guy Tremblay, Donna McLean, Raj S Padwal, Karen C Tran, Steven Grover, Simon W Rabkin, Gordon W Moe, et al.

Journal article  |  2018  |  Canadian Journal of Cardiology

Effect of Basal Insulin Glargine on First and Recurrent Episodes of Heart Failure Hospitalization The ORIGIN Trial (Outcome Reduction With Initial Glargine Intervention)

Hertzel C Gerstein, Hyejung Jung, Lars Ryden, Rafael Diaz, Richard E Gilbert, Salim Yusuf

Journal article  |  2018  |  Circulation

Chronic Kidney Disease, Basal Insulin Glargine, and Health Outcomes in People with Dysglycemia: The ORIGIN Study

Vasilios Papademetriou, Eric S Nylen, Michael Doumas, Jeff Probstfield, Johannes FE Mann, Richard E Gilbert, Hertzel C Gerstein

Journal article  |  2017  |  The American Journal of Medicine

Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults

Alexander A Leung, Stella S Daskalopoulou, Kaberi Dasgupta, Kerry McBrien, Sonia Butalia, Kelly B Zarnke, Kara Nerenberg, Kevin C Harris, Meranda Nakhla, Lyne Cloutier, Mark Gelfer, Maxime Lamarre-Cliche, Alain Milot, Peter Bolli, Guy Tremblay, Donna McLean, Sheldon W Tobe, Marcel Ruzicka, Kevin D Burns, Michel Vallee, et al.

Journal article  |  2017  |  Canadian Journal of Cardiology

Effects of Canagliflozin on Serum Magnesium in Patients With Type 2 Diabetes Mellitus: A Post Hoc Analysis of Randomized Controlled Trials

Richard E Gilbert, Christian Mende, Ujjwala Vijapurkar, Sue Sha, Michael J Davies, Mehul Desai

Journal article  |  2017  |  Diabetes Therapy

A new anti-fibrotic drug attenuates cardiac remodeling and systolic dysfunction following experimental myocardial infarction

Yuan Zhang, Maros Elsik, Amanda J Edgley, Alison J Cox, Andrew R Kompa, Bing Wang, Christina Yan Ru Tan, Fay L Khong, David I Stapleton, Steven Zammit, Spencer J Williams, Richard E Gilbert, Henry Krum, Darren J Kelly

Journal article  |  2013  |  International Journal of Cardiology

Combination Angiotensin Converting Enzyme and Direct Renin Inhibition in Heart Failure following Experimental Myocardial Infarction

KA Connelly, A Advani, S Advani, Y Zhang, K Thai, S Thomas, H Krum, DJ Kelly, RE Gilbert

Journal article  |  2013  |  Cardiovascular Therapeutics

A Purpose-Synthesised Anti-Fibrotic Agent Attenuates Experimental Kidney Diseases in the Rat

Richard E Gilbert, Yuan Zhang, Spencer J Williams, Steven C Zammit, David I Stapleton, Alison J Cox, Henry Krum, Robyn Langham, Darren J Kelly

Journal article  |  2012  |  PLoS One

FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy

Yuan Zhang, Amanda J Edgley, Alison J Cox, Andrew K Powell, Bing Wang, Andrew R Kompa, David I Stapleton, Steven C Zammit, Spencer J Williams, Henry Krum, Richard E Gilbert, Darren J Kelly

Journal article  |  2012  |  European Journal of Heart Failure

Protein kinase C beta inhibition ameliorates experimental mesangial proliferative glomerulonephritis

Hirobumi Tokuyama, Sandra Kim, Yuan Zhang, Robyn G Langham, Alison J Cox, Renae M Gow, Darren J Kelly, Richard E Gilbert

Journal article  |  2011  |  Nephrology

Aliskiren increases bradykinin and tissue kallikrein mRNA levels in the heart

Duncan J Campbell, Yuan Zhang, Darren J Kelly, Richard E Gilbert, Davis J McCarthy, Wei Shi, Gordon K Smyth

Journal article  |  2011  |  Clinical and Experimental Pharmacology and Physiology

Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy

Andrew Advani, Kathryn J Wiggins, Alison J Cox, Yuan Zhang, Richard E Gilbert, Darren J Kelly

Journal article  |  2011  |  Nephrology

The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy

Kim A Connelly, Andrew Advani, Sandra Kim, Suzanne L Advani, Michael Zhang, Kathryn E White, Young M Kim, Colleen Parker, Kerri Thai, Henry Krum, Darren J Kelly, Richard E Gilbert

Journal article  |  2011  |  Journal of Hypertension

Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism

Andrew Advani, Qingling Huang, Kerri Thai, Suzanne L Advani, Kathryn E White, Darren J Kelly, Darren A Yuen, Kim A Connelly, Philip A Marsden, Richard E Gilbert

Journal article  |  2011  |  American Journal of Pathology

Effect of Atorvastatin on Cardiac Remodelling and Mortality in Rats Following Hyperglycemia and Myocardial Infarction

Jennifer H Martin, Kim A Connelly, Andrew Boyle, Andrew Kompa, Yuan Zhang, Darren Kelly, Richard E Gilbert, Henry Krum

Journal article  |  2010  |  International Journal of Cardiology

Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction

Sih Min Tan, Yuan Zhang, Kim A Connelly, Richard E Gilbert, Darren J Kelly

Journal article  |  2010  |  American Journal of Physiology - Heart and Circulatory Physiology

Culture-Modified Bone Marrow Cells Attenuate Cardiac and Renal Injury in a Chronic Kidney Disease Rat Model via a Novel Antifibrotic Mechanism

Darren A Yuen, Kim A Connelly, Andrew Advani, Christine Liao, Michael A Kuliszewski, Judy Trogadis, Kerri Thai, Suzanne L Advani, Yuan Zhang, Darren J Kelly, Howard Leong-Poi, Armand Keating, Philip A Marsden, Duncan J Stewart, Richard E Gilbert

Journal article  |  2010  |  PLoS One

EGFR-PLC gamma 1 signaling mediates high glucose-induced PKC beta 1-Akt activation and collagen I upregulation in mesangial cells

D Wu, F Peng, B Zhang, AJ Ingram, DJ Kelly, RE Gilbert, B Gao, S Kumar, JC Krepinsky

Journal article  |  2009  |  American Journal of Physiology: Renal Physiology

PKC-beta 1 Mediates Glucose-Induced Akt Activation and TGF-beta 1 Upregulation in Mesangial Cells

Dongcheng Wu, Fangfang Peng, Baifang Zhang, Alistair J Ingram, Darren J Kelly, Richard E Gilbert, Bo Gao, Joan C Krepinsky

Journal article  |  2009  |  Journal of the American Society of Nephrology

Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenic Ren-2 rats

Kathryn J Wiggins, Victoria Tiauw, Yuan Zhang, Richard E Gilbert, Robyn G Langham, Darren J Kelly

Journal article  |  2008  |  Nephrology

Effect of urotensin II on skin microvessel tone in diabetic patients without heart failure or essential hypertension

E Zomer, I de Ridder, A Kompa, P Komesaroff, RE Gilbert, H Krum

Journal article  |  2008  |  Clinical and Experimental Pharmacology and Physiology

Letter by Connelly et al regarding article, "Diastolic Stiffness of the Failing Diabetic Heart: Importance of Fibrosis, Advanced Glycation End Products, and Myocyte Resting Tension"

Kim A Connelly, Richard E Gilbert, Henry Krum

Journal article  |  2008  |  Circulation

Activated protein C and diabetic nephropathy

Richard E Gilbert, Philip A Marsden

Journal article  |  2008  |  New England Journal of Medicine

Increased renal gene transcription of protein kinase C-beta in human diabetic nephropathy: relationship to long-term glycaemic control

RG Langham, DJ Kelly, RM Gow, Y Zhang, AJ Cox, W Qi, K Thai, CA Pollock, PK Christensen, H-H Parving, RE Gilbert

Journal article  |  2008  |  Diabetologia

Tranilast ameliorates experimental mesangial proliferative glomerulonephritis

Hirobumi Tokuyama, Darren J Kelly, Alison Cox, Yuan Zhang, Kerri Thai, David J Nikolic-Paterson, Richard E Gilbert

Journal article  |  2008  |  Nephron Experimental Nephrology

Preparation of cinnamoyl anthranilates and analogs thereof with antifibrotic activity

S ZAMMIT, R GILBERT, H KRUM, S WILLIAMS, D KELLY

Patent  |  2008

Functional, structural and molecular aspects of diastolic heart failure in the diabetic (mRen-2)27 rat

KA Connelly, DJ Kelly, Y Zhang, DL Prior, J Martin, AJ Cox, K Thai, MP Feneley, J Tsoporis, KE White, H Krum, RE Gilbert

Journal article  |  2007  |  Cardiovascular Research

Tranilast attenuates diastolic dysfunction and structural injury in experimental diabetic cardiomyopathy

Darren J Kelly, Yuan Zhang, Kim Connelly, Alison J Cox, Jennifer Martin, Henry Krum, Richard E Gilbert

Journal article  |  2007  |  American Journal of Physiology - Heart and Circulatory Physiology

High glucose induces macrophage inflammatory protein-3 alpha in renal proximal tubule cells via a transforming growth factor-beta 1 dependent mechanism

Weier Qi, Xinming Chen, Yuan Zhang, John Holian, Ellein Mreich, Richard E Gilbert, Darren J Kelly, Carol A Pollock

Journal article  |  2007  |  Nephrology, Dialysis, Transplantation

Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats

DJ Kelly, Y Zhang, G Moe, G Naik, RE Gilbert

Journal article  |  2007  |  Diabetologia

Clinically relevant models of diabetic cardiac complications

Kim Connelly, Darren Kelly, Richard Gilbert

Journal article  |  2007  |  Circulation Research

Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions

Andrew Advani, Darren J Kelly, Suzanne L Advani, Alison J Cox, Kerri Thai, Yuan Zhang, Kathryn E White, Renae M Gow, Sally M Marshall, Brent M Steer, Philip A Marsden, P Elizabeth Rakoczy, Richard E Gilbert

Journal article  |  2007  |  Proceedings of the National Academy of Sciences of the United States of America

High glucose-induced thioredoxin-interacting protein in renal proximal tubule cells is independent of transforming growth factor-beta 1

Weier Qi, Xinming Chen, Richard E Gilbert, Yuan Zhang, Mark Waltham, Maria Sclhache, Darren J Kelly, Carol A Pollock

Journal article  |  2007  |  American Journal of Pathology

Effects on protein kinase C-beta inhibition on glomerular vascular endothelial growth factor expression and endothelial cells in advanced experimental diabetic nephropathy

Darren J Kelly, Danielle Buck, Alison J Cox, Yuan Zhang, Richard E Gilbert

Journal article  |  2007  |  American Journal of Physiology: Renal Physiology

Advanced glycation end products decrease mesangial cell MMP-7: A role in matrix accumulation in diabetic nephropathy?

SV McLennan, DJ Kelly, M Schache, M Waltham, V Dy, RG Langham, DK Yue, RE Gilbert

Journal article  |  2007  |  Kidney International

Expression of filtrin in human glomerular diseases

Pekka Ihalmo, Holger Schmid, Maria Pia Rastaldi, Deborah Mattinzoli, Robyn G Langham, Pauliina Luimula, Riika Kilpikari, Markus Lassila, Richard E Gilbert, Dontscho Kerjaschki, Matthias Kretzler, Harry Holthefer

Journal article  |  2007  |  Nephrology, Dialysis, Transplantation

The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1

Weier Qi, Xinming Chen, Stephen Twigg, Yuan Zhang, Richard E Gilbert, Darren J Kelly, Carol A Pollock

Journal article  |  2007  |  Nephrology

Progressive diabetic nephropathy in the Ren-2 rat

Darren J Kelly, Jennifer L Wilkinson-Berka, Richard E Gilbert

Journal article  |  2007  |  American Journal of Physiology: Renal Physiology

Effect of ruboxistaurin on urina transforming growth factor-beta in patients with diabetic nephropathy and type 2 diabetes

Richard E Gilbert, Sandra A Kim, Katherine R Tuttle, George L Bakris, Robert D Toto, Janet B McGill, Douglas J Haney, Darren J Kelly, Pamela W Anderson

Journal article  |  2007  |  Diabetes Care

Macrophage infiltration and cellular proliferation in the non-ischemic kidney and heart following prolonged unilateral renal ischemia

Hirobumi Tokuyama, Darren J Kelly, Yuan Zhang, Renae M Gow, Richard E Gilbert

Journal article  |  2007  |  Nephron Physiology

Transforming growth factor-beta in human diabetic nephropathy - Effects of ACE inhibition

Robyn G Langham, Darren J Kelly, Yuan Zhang, Daniel J Cordonnier, Nicole Pinel, Phillipe Zaoui, Richard E Gilbert

Journal article  |  2006  |  Diabetes Care

Transforming growth factor-beta(1) differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells

Weier Qi, Xinming Chen, John Holian, Ellein Mreich, Stephen Twigg, Richard E Gilbert, Carol A Pollock

Journal article  |  2006  |  American Journal of Physiology: Renal Physiology

Combination therapy with tranilast and angiotensin-converting enzyme inhibition provides additional renoprotection in the remnant kidney model.

DJ Kelly, Y Zhang, AJ Cox, RE Gilbert

Journal article  |  2006  |  Kidney International

Despite current therapy with agents that block the renin-angiotensin system, renal dysfunction continues to progress in a signific..

Importance of renin in blood pressure regulation and therapeutic potential of renin inhibition

A Ferro, R Gilbert, H Krum

Journal article  |  2006  |  International Journal of Clinical Practice

Intra-coronary high-dose CD34 stem cells in patients with chronic ischemic heart disease: A 12-month follow-up

AJ Boyle, R Whitbourn, S Schlicht, H Krum, A Kocher, H Nandurkar, S Bergmann, M Daniell, J O'Day, D Skerrett, D Haylock, RE Gilbert, S Itescu

Journal article  |  2006  |  International Journal of Cardiology

Load-sensitive measures may overestimate global systolic function in the presence of left ventricular hypertrophy: a comparison with load-insensitive measures

KA Connelly, DL Prior, DJ Kelly, MP Feneley, H Krum, RE Gilbert

Journal article  |  2006  |  American Journal of Physiology - Heart and Circulatory Physiology

SB-267268, a nonpeptidic antagonist of alpha(v)beta(3) and alpha(v)beta(5) integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity

JL Wilkinson-Berka, D Jones, G Taylor, K Jaworski, DJ Kelly, SB Ludbrook, RN Willette, SJ Kumar, RE Gilbert

Journal article  |  2006  |  Investigative Ophthalmology and Visual Science

Tranilast attenuates connective tissue growth factor-induced extracellular matrix accumulation in renal cells

W Qi, X Chen, S Twigg, TS Polhill, RE Gilbert, CA Pollock

Journal article  |  2006  |  Kidney International

TGF-beta(1) induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway

W Qi, XM Chen, TS Polhill, S Sumual, S Twigg, RE Gilbert, CA Pollock

Journal article  |  2006  |  American Journal of Physiology: Renal Physiology

Heart failure and nephropathy: Catastrophic and interrelated complications of diabetes

Richard E Gilbert, Kim Connelly, Darren J Kelly, Carol A Pollock, Henry Krum

Journal article  |  2006  |  Journal of the American Society of Nephrology

Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the Irbesartan Diabetic Nephropathy Trial: Clinical implications and limitations

MA Pohl, S Blumenthal, DJ Cordonnier, F De Alvaro, G DeFerrari, G Eisner, E Esmatjes, RE Gilbert, LG Hunsicker, JBL de Faria, R Mangili, J Moore, E Reisin, E Ritz, G Schernthaner, S Spitalewitz, H Tindall, RA Rodby, EJ Lewis

Journal article  |  2005  |  Journal of the American Society of Nephrology

High glucose transactivates the EGF receptor and up-regulates serum glucocorticoid kinase in the proximal tubule

S Saad, VA Stevens, L Wassef, P Poronnik, DJ Kelly, RE Gilbert, CA Pollock

Journal article  |  2005  |  Kidney International

Renin inhibition - New potential for an old therapeutic target

DJ Kelly, JL Wilkinson-Berka, RE Gilbert

Journal article  |  2005  |  Hypertension

Glargine is superior to neutral protamine Hagedorn for improving glycated haemoglobin and fasting blood glucose levels during intensive insulin therapy

GR Fulcher, RE Gilbert, DK Yue

Journal article  |  2005  |  Internal Medicine Journal

Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction

A BOYLE, D KELLY, Y ZHANG, A COX, R GOW, K WAY, S ITESCU, H KRUM, R GILBERT

Journal article  |  2005  |  Journal of Molecular and Cellular Cardiology

Protein kinase C beta inhibition attenuates osteopontin expression, macrophage recruitment, and tubulointerstitial injury in advanced experimental diabetic nephropathy

DJ Kelly, A Chanty, RM Gow, Y Zhang, RE Gilbert

Journal article  |  2005  |  Journal of the American Society of Nephrology

Cells expressing the stem cell factor receptor, c-kit, contribute to neoangiogenesis in diabetes.

Darren J Kelly, Yuan Zhang, Renae M Gow, Silviu Itescu, Richard E Gilbert

Journal article  |  2005  |  Diabetes and Vascular Disease Research

While neoangiogenesis in diabetes is of greatest clinical significance in the retina, the pathological formation of new blood vess..

Integrated actions of transforming growth factor-beta(1) and connective tissue growth factor in renal fibrosis

W Qi, S Twigg, X Chen, TS Polhill, P Poronnik, RE Gilbert, CA Pollock

Journal article  |  2005  |  American Journal of Physiology: Renal Physiology

Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-beta

J Martin, DJ Kelly, SA Mifsud, Y Zhang, AJ Cox, F See, H Krum, J Wilkinson-Berka, RE Gibert

Journal article  |  2005  |  Cardiovascular Research

Long-term renoprotection by perindopril or nifedipine in non-hypertensive patients with Type 2 diabetes and microalbuminuria

G Jerums, TJ Allen, DJ Campbell, ME Cooper, RE Gilbert, JJ Hammond, RC O'Brien, J Raffaele, C Tsalamandris

Journal article  |  2004  |  Diabetic Medicine

Increased expression of urotensin II and urotensin II receptor in human diabetic nephropathy

RG Langham, DJ Kelly, RM Gow, Y Zhang, JK Dowling, NM Thomson, RE Gilbert

Journal article  |  2004  |  American Journal of Kidney Diseases

Epidermal growth factor receptor inhibition attenuates early kidney enlargement in experimental diabetes

L Wassef, DJ Kelly, RE Gilbert

Journal article  |  2004  |  Kidney International

Tranilast attenuates structural and functional aspects of renal injury in the remnant kidney model

DJ Kelly, Y Zhang, R Gow, RE Gilbert

Journal article  |  2004  |  Journal of the American Society of Nephrology

Tranilast reduces mesenteric vascular collagen deposition and chymase-positive mast cells in experimental diabetes

SE Jones, RE Gilbert, DJ Kelly

Journal article  |  2004  |  Journal of Diabetes and its Complications

Platelet-derived growth factor receptor transactivation mediates the trophic effects of angiotensin II in vivo

DJ Kelly, AJ Cox, RM Gow, Y Zhang, BE Kemp, RE Gilbert

Journal article  |  2004  |  Hypertension

Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy

JL Wilkinson-Berka, S Babic, T de Gooyer, AW Stitt, K Jaworski, LGT Ong, DJ Kelly, RE Gilbert

Journal article  |  2004  |  American Journal of Pathology

Fas-induced apoptosis is a feature of progressive diabetic nephropathy in transgenic (mRen-2)27 rats: Attenuation with renin-angiotensin blockade

DJ Kelly, A Stein-Oakley, YA Zhang, L Wassef, J Maguire, T Koji, N Thomson, JL Wilkinson-Berka, RE Gilbert

Journal article  |  2004  |  Nephrology

A study of VEGF and its receptors in two rat models of proteinuria.

John Kanellis, Vicki Levidiotis, Tiffany Khong, Alison J Cox, Steven A Stacker, Richard E Gilbert, Mark E Cooper, David A Power

Journal article  |  2004  |  Nephron

BACKGROUND: The high level of expression of vascular endothelial growth factor (VEGF) in normal podocyte foot processes suggests t..

Angiotensin II-induced proteinuria and expression of the podocyte slit pore membrane protein, nephrin

RG Langham, DJ Kelly, AJ Cox, RM Gow, H Holthofer, RE Gilbert

Journal article  |  2004  |  Nephrology, Dialysis, Transplantation

Drug therapy for the cardiac complications of diabetes

K Connelly, DJ Kelly, R Langham, H Krum, RE Gilbert

Journal article  |  2004  |  Drug Discovery Today: Therapeutic Strategies

Are beta-blockers as efficacious in patients with diabetes mellitus as in patients without diabetes mellitus who have chronic heart failure? A meta-analysis of large-scale clinical trials

SJ Haas, T Vos, RE Gilbert, H Krum

Journal article  |  2003  |  American Heart Journal

Does vascular endothelial growth factor (VEGF) play a role in the pathogenesis of minimal change disease?

G Boner, AJ Cox, DJ Kelly, A Tobar, J Bernheim, RG Langham, ME Cooper, RE Gilbert

Journal article  |  2003  |  Nephrology, Dialysis, Transplantation

STI-571 inhibits in vitro angiogenesis

A Dudley, RE Gilbert, D Thomas, A Cox, JT Price, J Best, A Jenkins

Journal article  |  2003  |  Biochemical and Biophysical Research Communications

Urinary Connective Tissue Growth Factor Excretion in Patients With Type 1 Diabetes and Nephropathy

RE Gilbert, A Akdeniz, S Weitz, WR Usinger, C Molineaux, SE Jones, RG Langham, G Jerums

Journal article  |  2003  |  Diabetes Care

Comparative metabolic effects of hydrochlorothiazide and indapamide in hypertensive diabetic patients receiving ACE inhibitor therapy

H Krum, M Skiba, RE Gilbert

Journal article  |  2003  |  Diabetic Medicine

Tranilast attenuates vascular hypertrophy, matrix accumulation and growth factor overexpression in experimental diabetes

F Bonnet, Z Cao, ME Cooper, AJ Cox, DJ Kelly, RE Gilbert

Journal article  |  2003  |  Diabetes & Metabolism

Mast cell infiltration and chemokine expression in progressive renal disease

SE Jones, DJ Kelly, AJ Cox, Y Zhang, RM Gow, RE Gilbert

Journal article  |  2003  |  Kidney International

Direct actions of urotensin II on the heart - Implications for cardiac fibrosis and hypertrophy

A Tzanidis, RD Hannan, WG Thomas, D Onan, DJ Autelitano, F See, DJ Kelly, RE Gilbert, H Krum

Journal article  |  2003  |  Circulation Research

The renin-angiotensin system and the long-term complications of diabetes: pathophysiological and therapeutic considerations

RE Gilbert, H Krum, J Wilkinson-Berka, DJ Kelly

Journal article  |  2003  |  Diabetic Medicine

Demographics and concomitant disorders in heart failure

H Krum, RE Gilbert

Journal article  |  2003  |  The Lancet

Over-expression of platelet-derived growth factor in human diabetic nephropathy

RG Langham, DJ Kelly, J Maguire, JP Dowling, RE Gilbert, NM Thomson

Journal article  |  2003  |  Nephrology, Dialysis, Transplantation

Vascular endothelial growth factor expression and glomerular endothelial cell loss in the remnant kidney model

DJ Kelly, C Hepper, LL Wu, AJ Cox, RE Gilbert

Journal article  |  2003  |  Nephrology, Dialysis, Transplantation

COX-2 inhibition and retinal angiogenesis in a mouse model of retinopathy of prematurity

JL Wilkinson-Berka, NS Alousis, DJ Kelly, RE Gilbert

Journal article  |  2003  |  Investigative Ophthalmology and Visual Science

Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension

DJ Kelly, YA Zhang, C Hepper, RM Gow, K Jaworski, BE Kemp, JL Wilkinson-Berka, RE Gilbert

Journal article  |  2003  |  Diabetes

Metabolic comorbid conditions in chronic heart failure: diabetes and hypercholesterolaemia

H KRUM, JLM MARTIN, SJ HAAS, RE GILBERT

Book Chapter  |  2003

Urotensin II: a new player in vascular and myocardial disease?

H Krum, RE Gilbert

Journal article  |  2003  |  Clinical Science

The renin-angiotensin system influences ocular endothelial cell proliferation in diabetes - Transgenic and interventional studies

CJ Moravski, SL Skinner, AJ Stubbs, S Sarlos, DJ Kelly, ME Cooper, RE Gilbert, JL Wilkinson-Berka

Journal article  |  2003  |  American Journal of Pathology

The pathogenesis of diabetic nephropathy

RE GILBERT, ME COOPER, B WILLIAMS

Book Chapter  |  2003

Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy.

Sally Mifsud, Darren J Kelly, Weier Qi, Yuan Zhang, Carol A Pollock, Jennifer L Wilkinson-Berka, Richard E Gilbert

Journal article  |  2003  |  Nephron Physiology

BACKGROUND/AIMS: Tubulointerstitial pathology with the accumulation of extracellular matrix are pathological hallmarks of diabetic..

Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition

RG Langham, DJ Kelly, AJ Cox, NM Thomson, H Holthofer, P Zaoui, N Pinel, DJ Cordonnier, RE Gilbert

Journal article  |  2002  |  Diabetologia

Expression of the slit-diaphragm protein, nephrin, in experimental diabetic nephropathy: differing effects of anti-proteinuric therapies

DJ Kelly, P Aaltonen, AJ Cox, JR Rumble, R Langham, S Panagiotopoulos, G Jerums, H Holthofer, RE Gilbert

Journal article  |  2002  |  Nephrology, Dialysis, Transplantation

Progression of tubulointerstitial injury by osteopontin-induced macrophage recruitment in advanced diabetic nephropathy of transgenic (mRen-2)27 rats

DJ Kelly, JL Wilkinson-Berka, SD Ricardo, AJ Cox, RE Gilbert

Journal article  |  2002  |  Nephrology, Dialysis, Transplantation

Renal ischemia-reperfusion increases endothelial VEGFR-2 without increasing VEGF or VEGFR-1 expression

J Kanellis, K Paizis, AJ Cox, SA Stacker, RE Gilbert, ME Cooper, DA Power

Journal article  |  2002  |  Kidney International

Decreased matrix degradation in diabetic nephropathy: effects of ACE inhibition on the expression and activities of matrix metalloproteinases

SV McLennan, DJ Kelly, AJ Cox, Z Cao, JG Lyons, DK Yue, RE Gilbert

Journal article  |  2002  |  Diabetologia

Urinary transforming growth factor-β excretion in patients with hypertension, type 2 diabetes, and elevated albumin excretion rate

CA HOULIHAN, ME COOPER, A AKDENIZ, G JERUMS, C TSALAMANDRIS, RE GILBERT

Journal article  |  2002  |  Diabetes Care

Attenuation of tubular apoptosis by blockade of the renin-angiotensin system in diabetic Ren-2 rats

DJ Kelly, AJ Cox, M Tolcos, ME Cooper, JL Wilkinson-Berka, RE Gilbert

Journal article  |  2002  |  Kidney International

Transforming growth factor-beta 1 and tumor growth factor-beta-inducible gene-H3 in nonrenal transplant cyclosporine nephropathy

RG Langham, MK Egan, JP Dowling, RE Gilbert, NM Thomson

Journal article  |  2001  |  Transplantation

Urinary transforming growth factor-beta in patients with diabetic nephropathy: implications for the pathogenesis of tubulointerstitial pathology

RE Gilbert, A Akdeniz, TJ Allen, G Jerums

Journal article  |  2001  |  Nephrology, Dialysis, Transplantation

The interaction between the renin-angiotensin system and vascular endothelial growth factor in the pathogenesis of retinal neovascularization in diabetes

JL Wilkinson-Berka, DJ Kelly, RE Gilbert

Journal article  |  2001  |  Journal of Vascular Research

Renal protection by angiotensin II receptor antagonists in patients with type 2 diabetes

G Jerums, ME Cooper, RE Gilbert, RC Atkins

Journal article  |  2001  |  Medical Journal of Australia

Aminoguanidine ameliorates overexpression of prosclerotic growth factors and collagen deposition in experimental diabetic nephropathy

DJ Kelly, RE Gilbert, AJ Cox, T Soulis, GT Jerums, ME Cooper

Journal article  |  2001  |  Journal of the American Society of Nephrology

Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis

G Paizis, RE Gilbert, ME Cooper, P Murthi, JM Schembri, LL Wu, JR Rumble, DJ Kelly, C Tikellis, A Cox, RA Smallwood, PW Angus

Journal article  |  2001  |  Journal of Hepatology

Vasopeptidase inhibition attenuates the progression of renal injury in subtotal nephrectomized rats

ZM Cao, LM Burrell, I Tikkanen, F Bonnet, ME Cooper, RE Gilbert

Journal article  |  2001  |  Kidney International

Podocyte foot process broadening in experimental diabetic nephropathy: amelioration with renin-angiotensin blockade

SA Mifsud, TJ Allen, JF Bertram, UL Hulthen, DJ Kelly, ME Cooper, JL Wilkinson-Berka, RE Gilbert

Journal article  |  2001  |  Diabetologia

Long-term comparison between perindopril and nifedipine in normotensive patients with type 1 diabetes and microalbuminuria

G Jerums, TJ Allen, DJ Campbell, ME Cooper, RE Gilbert, JJ Hammond, J Raffaele, C Tsalamandris

Journal article  |  2001  |  American Journal of Kidney Diseases

PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis

RE Gilbert, DJ Kelly, T McKay, S Chadban, PA Hill, ME Cooper, RC Atkins, DJ Nikolic-Paterson

Journal article  |  2001  |  Kidney International

Novel approaches to the treatment of progressive renal disease.

RE Gilbert, DJ Kelly, RC Atkins

Journal article  |  2001  |  Current Opinion in Pharmacology

Diabetes and hypertension are major contributors to the increasing incidence of progressive renal disease. In addition to more pot..

Angiotensin and renal fibrosis

RE Gilbert, JL Wilkinson-Berka, DJ Kelly

Journal article  |  2001  |  Contributions to Nephrology

Nephropathy in type 2 diabetes: Current therapeutic strategies

RE Gilbert, DJ Kelly

Journal article  |  2001  |  Nephrology

Angiotensin-converting enzyme inhibition attenuates renal platelet-derived growth factor gene expression and cell proliferation in subtotal nephrectomy

K Jandeleit-Dahm, LL Wu, RJ Johnson, AJ Cox, DJ Kelly, ME Cooper, RE Gilbert

Journal article  |  2001  |  Nephrology

Letter to the Editor. Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes.

RE GILBERT

Journal article  |  2001  |  New England Journal of Medicine