Roy Kong

Inhibitory Effects of 3',4'-Dihydroxyflavonol in a Mouse Model of Glaucoma Filtration Surgery and TGFβ1-Induced Responses in Human Tenon's Fibroblasts.

Jennifer C Fan Gaskin, Roy CK Kong, Manisha H Shah, Amanda J Edgley, Hitesh M Peshavariya, Elsa C Chan

Journal article  |  2022  |  Transl Vis Sci Technol

PURPOSE: Cytotoxic agents such as mitomycin C (MMC) are part of the mainstay treatment for limiting subconjunctival scarring follo..

Transcriptomic analysis of choroidal neovascularization reveals dysregulation of immune and fibrosis pathways that are attenuated by a novel anti-fibrotic treatment

Alice Brandli, Fay L Khong, Roy CK Kong, Darren J Kelly, Erica L Fletcher

Journal article  |  2022  |  SCIENTIFIC REPORTS

Neovascular AMD (nAMD) leads to vision loss and is a leading cause of visual impairment in the industrialised world. Current treat..

Oral delivery of the anti-fibrotic, FT011, achieves safe and robust intraocular levels of exposure in subjects undergoing glaucoma filtration surgery

Jennifer Fan Gaskin, Nathan Kerr, Michelle Pauline Papadimitriou, Roy Chze Khai Kong, Fay Lin Khong, Darren Kelly

Conference Proceedings  |  2020  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

OCX063, a novel small molecule drug, is protective against inflammatory, fibrotic and angiogenic phenotypes in retinal cultures

Roy Chze Khai Kong, Elsa Chan, Alison J Cox, Sylwia Glowacka, Fay Lin Khong, Michelle Pauline Papadimitriou, Darren Kelly

Conference Proceedings  |  2020  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Oral administration of the novel small molecule drug OCX063 protects against inflammation and vascular pathology in a rat diabetic retinopathy (DR) model

Roy Chze Khai Kong, Amanda Edgley, Elsa Chan, Alison J Cox, Sylwia Glowacka, Michelle Papadimitriou, Fay Lin Khong, Darren Kelly

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

OCX063, A Novel Small Molecule Drug, Exhibits Anti-Inflammatory and Anti-Fibrotic Properties in Retinal Cultures

Roy Chze Khai Chze Khai Kong, Alison J Cox, Sylwia Glowacka, Darren J Kelly, Fay Khong

Conference Proceedings  |  2017  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

The protective effect of OCX063 on reducing neovascularization and lesion size in a mouse model of choroidal neovascularization.

Erica L Fletcher, Alice A Brandli, Roy Kong, Fay Khong, Darren J Kelly

Conference Proceedings  |  2017  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Mapping Key Regions of the RXFP2 Low-Density Lipoprotein Class-A Module That Are Involved in Signal Activation

Roy CK Kong, Ross AD Bathgate, Shoni Bruell, John D Wade, Paul R Gooley, Emma J Petrie

Journal article  |  2014  |  BIOCHEMISTRY

The peptide hormone INSL3 and its receptor, RXFP2, have co-evolved alongside relaxin and its receptor, RXFP1. Both RXFP1 and RXFP2..

The Relaxin Receptor (RXFP1) Utilizes Hydrophobic Moieties on a Signaling Surface of Its N-terminal Low Density Lipoprotein Class A Module to Mediate Receptor Activation

Roy CK Kong, Emma J Petrie, Biswaranjan Mohanty, Jason Ling, Jeremy CY Lee, Paul R Gooley, Ross AD Bathgate

Journal article  |  2013  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The peptide hormone relaxin is showing potential as a treatment for acute heart failure. Although it is known that relaxin mediate..

Chimeric RXFP1 and RXFP2 Receptors Highlight the Similar Mechanism of Activation Utilizing Their N-Terminal Low-Density Lipoprotein Class A Modules.

Shoni Bruell, Roy CK Kong, Emma J Petrie, Brad Hoare, John D Wade, Daniel J Scott, Paul R Gooley, Ross AD Bathgate

Journal article  |  2013  |  Front Endocrinol (Lausanne)

Relaxin family peptide (RXFP) receptors 1 and 2 are unique G-protein coupled receptors in that they contain an N-terminal low-dens..