Sophie Zaloumis

Parasite-host dynamics throughout antimalarial drug development stages complicate the translation of parasite clearance.

Lydia Burgert, Sophie Zaloumis, Saber Dini, Louise Marquart, Pengxing Cao, Mohammed Cherkaoui, Nathalie Gobeau, James McCarthy, Julie A Simpson, Jörg J Möhrle, Melissa A Penny

Journal article  |  2021  |  Antimicrobial Agents and Chemotherapy

Ensuring continued success against malaria depends on a pipeline of new antimalarials. Antimalarial drug development utilizes pre-..

Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial

David S Khoury, Pengxing Cao, Sophie G Zaloumis, Miles P Davenport

Journal article  |  2020  |  Trends in Parasitology

Resistance to the artemisinin derivatives, our most effective antimalarial drugs, has not manifest as a classical resistance pheno..

Transient childhood wheeze is associated with less atopy in adolescence

Caroline Jane Lodge, Adrian John Lowe, Michael John Abramson, Cecilie Svanes, Sophie G Zaloumis, Paul S Thomas, Shyamali Chandrika Dharmage

Journal article  |  2020  |  Pediatric Allergy and Immunology

BACKGROUND: The relationships between childhood wheeze phenotypes and subsequent allergic conditions other than asthma, including ..

Malaria Parasite Clearance: What Are We Really Measuring?

David S Khoury, Sophie G Zaloumis, Matthew J Grigg, Ashraful Haque, Miles P Davenport

Journal article  |  2020  |  Trends in Parasitology

Differential impact of malaria control interventions on P. falciparum and P. vivax infections in young Papua New Guinean children

Maria Ome-Kaius, Johanna Helena Kattenberg, Sophie Zaloumis, Matthew Siba, Benson Kiniboro, Shadrach Jally, Zahra Razook, Daisy Mantila, Desmond Sui, Jason Ginny, Anna Rosanas-Urgell, Stephan Karl, Thomas Obadia, Alyssa Barry, Stephen J Rogerson, Moses Laman, Daniel Tisch, Ingrid Felger, James W Kazura, Ivo Mueller, et al.

Journal article  |  2019  |  BMC MEDICINE

INTRODUCTION: As malaria transmission declines, understanding the differential impact of intensified control on Plasmodium falcipa..

Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection

Pengxing Cao, Katharine A Collins, Sophie Zaloumis, Thanaporn Wattanakul, Joel Tarning, Julie A Simpson, James McCarthy, James M McCaw

Journal article  |  2019  |  eLife

Renewed efforts to eliminate malaria have highlighted the potential to interrupt human-to-mosquito transmission - a process mediat..

Contribution of Functional Antimalarial Immunity to Measures of Parasite Clearance in Therapeutic Efficacy Studies of Artemisinin Derivatives

Katherine O'Flaherty, Ricardo Ataide, Sophie G Zaloumis, Elizabeth A Ashley, Rosanna Powell, Gaoqian Feng, Linda Reiling, Arjen M Dondorp, Nicholas P Day, Mehul Dhorda, Rick M Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tinh Hien Tran, Ye Htut, Mayfong Mayxay, M Abul Faiz, James G Beeson, Francois Nosten, et al.

Journal article  |  2019  |  Journal of Infectious Diseases

BACKGROUND: Antibodies to the blood-stages of malaria enhance parasite-clearance and antimalarial efficacy. The antibody subclass ..

Sequential infection experiments for quantifying innate and adaptive immunity during influenza infection

Ada WC Yan, Sophie G Zaloumis, Julie A Simpson, James M McCaw

Journal article  |  2019  |  PLoS Computational Biology

In Silico Investigation of the Decline in Clinical Efficacy of Artemisinin Combination Therapies Due to Increasing Artemisinin and Partner Drug Resistance

Sophie G Zaloumis, Pengxing Cao, Saber Dini, Miles P Davenport, Deborah Cromer, David S Khoury, Freya JI Fowkes, James M McCaw, Julie A Simpson

Journal article  |  2018  |  Antimicrobial Agents and Chemotherapy

Investigating the Efficacy of Triple Artemisinin-Based Combination Therapies for Treating Plasmodium falciparum Malaria Patients Using Mathematical Modeling

Saber Dini, Sophie Zaloumis, Pengxing Cao, Ric N Price, Freya J Fowkes, E Rob W van der Pluijm, James M McCaw, Julie A Simpson

Journal article  |  2018  |  Antimicrobial Agents and Chemotherapy