Sophie Zaloumis

Utilising surface-level data to explore surface, tooth, individual and family influence on the aetiology of Hypomineralised Second Primary Molars.

MJ Silva, Y Zheng, S Zaloumis, DP Burgner, JM Craig, DJ Manton, NM Kilpatrick, KJ Scurrah

Journal article  |  2021  |  J Dent

OBJECTIVES: Hypomineralised second primary molars (HSPM) are common developmental enamel defects. The aims of this study were to u..

977Mechanistic within-host modelling to fast-track the selection of new antimalarial combination therapies

Julie Simpson, Saber Dini, Sophie Zaloumis, David Price, James McCarthy, Mohammed Cherkaoui, Anne Kummel, Nathalie Gobeau

Journal article  |  2021  |  International Journal of Epidemiology

Abstract Background The efficacy of artemisinin-based combination therapies (A..

Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria

Saber Dini, Sophie G Zaloumis, David J Price, Nathalie Gobeau, Anne Kummel, Mohammed Cherkaoui, Joerg J Moehrle, James S McCarthy, Julie A Simpson

Journal article  |  2021  |  JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

BACKGROUND: The efficacy of artemisinin-based combination therapies (ACTs), the first-line treatments for uncomplicated falciparum..

Development and Validation of an In Silico Decision Tool To Guide Optimization of Intravenous Artesunate Dosing Regimens for Severe Falciparum Malaria Patients

Sophie G Zaloumis, Jason M Whyte, Joel Tarning, Sanjeev Krishna, James M McCaw, Pengxing Cao, Michael T White, Saber Dini, Freya J Fowkes, Richard J Maude, Peter Kremsner, Arjen Dondorp, Ric N Price, Nicholas J White, Julie A Simpson

Journal article  |  2021  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Most deaths from severe falciparum malaria occur within 24 h of presentation to a hospital. Intravenous (i.v.) artesunate is the f..

Community-based molecular and serological surveillance of subclinical malaria in Myanmar

Katherine O'Flaherty, Win Han Oo, Sophie G Zaloumis, Julia C Cutts, Kyaw Zayar Aung, Myat Mon Thein, Damien R Drew, Zahra Razook, Alyssa E Barry, Naanki Parischa, Nyi Nyi Zaw, Htin Kyaw Thu, Aung Thi, Wai Yan Min Htay, Aung Paing Soe, Julie A Simpson, James G Beeson, Paul A Agius, Freya JI Fowkes

Journal article  |  2021  |  BMC MEDICINE

BACKGROUND: In the Greater Mekong Subregion (GMS), current malaria surveillance strategies rely on a network of village health vol..

Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance

Lydia Burgert, Sophie Zaloumis, Saber Dini, Louise Marquart, Pengxing Cao, Mohammed Cherkaoui, Nathalie Gobeau, James McCarthy, Julie A Simpson, Jorg J Mohrle, Melissa A Penny

Journal article  |  2021  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ensuring continued success against malaria depends on a pipeline of new antimalarials. Antimalarial drug development utilizes prec..

Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial

David S Khoury, Pengxing Cao, Sophie G Zaloumis, Miles P Davenport

Journal article  |  2020  |  TRENDS IN PARASITOLOGY

Resistance to the artemisinin derivatives, our most effective antimalarial drugs, has not manifest as a classical resistance pheno..

Malaria Parasite Clearance: What Are We Really Measuring?

David S Khoury, Sophie G Zaloumis, Matthew J Grigg, Ashraful Haque, Miles P Davenport

Journal article  |  2020  |  TRENDS IN PARASITOLOGY

Antimalarial drugs are vital for treating malaria and controlling transmission. Measuring drug efficacy in the field requires larg..

Differential impact of malaria control interventions on P. falciparum and P. vivax infections in young Papua New Guinean children

Maria Ome-Kaius, Johanna Helena Kattenberg, Sophie Zaloumis, Matthew Siba, Benson Kiniboro, Shadrach Jally, Zahra Razook, Daisy Mantila, Desmond Sui, Jason Ginny, Anna Rosanas-Urgell, Stephan Karl, Thomas Obadia, Alyssa Barry, Stephen J Rogerson, Moses Laman, Daniel Tisch, Ingrid Felger, James W Kazura, Ivo Mueller, et al.

Journal article  |  2019  |  BMC MEDICINE

INTRODUCTION: As malaria transmission declines, understanding the differential impact of intensified control on Plasmodium falcipa..

Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection

Pengxing Cao, Katharine A Collins, Sophie Zaloumis, Thanaporn Wattanakul, Joel Tarning, Julie A Simpson, James McCarthy, James M McCaw

Journal article  |  2019  |  ELIFE

Renewed efforts to eliminate malaria have highlighted the potential to interrupt human-to-mosquito transmission - a process mediat..