Neil O'Brien-Simpson

Synthetic peptide constructs for the diagnosis and treatment of periodontitis associated with Porphyromonas gingivalis

E REYNOLDS, N O'BRIEN-SIMPSON, N SLAKESKI

Synthetic peptides containing protective epitopes for the treatment and prevention of periodontitis associated with porphyromonas gingivalis

N O'BRIEN-SIMPSON, E REYNOLDS

Antimicrobial nanoparticle coatings for medical implants: Design challenges and prospects.

Xin Li, Tao Huang, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

Journal article  |  2020  |  Biointerphases

Microbial colonization, infection, and biofilm formation are major complications in the use of implants and are the predominant ri..

Peripheral T helper cell profiles during management of periodontitis

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Neil M O'Brien-Simpson, Eric C Reynolds, Ivan B Darby

Journal article  |  2020  |  Journal of Clinical Periodontology

AIM: Periodontitis has been associated with other systemic diseases with underlying inflammation responsible for the shared link. ..

Peripheral memory T-cell profile is modified in patients undergoing periodontal management.

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, James A Holden, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson

Journal article  |  2020  |  Journal of Clinical Periodontology

AIMS: T-cells are known to have a role in periodontitis, however, the effect of periodontal therapy on peripheral memory T-cells i..

A review of T helper 17 cell-related cytokines in serum and saliva in periodontitis.

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson

Journal article  |  2020  |  Cytokine

Periodontitis is a chronic inflammatory disease with a complex underlying immunopathology. Cytokines, as molecular mediators of in..

Acute phase protein and cytokine levels in serum and saliva: A comparison of detectable levels and correlations in a depressed and healthy adolescent sample (vol 34, pg 164, 2013)

Michelle L Byrne, Neil M O'Brien-Simpson, Eric C Reynolds, Katrina A Walsh, Katrina Laughton, Joanna M Waloszek, Michael J Woods, John Trinder, Nicholas B Allen

Journal article  |  2020  |  Brain, Behavior, and Immunity

T helper 17 cell-related cytokines in serum and saliva during management of periodontitis

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Ivan B Darby, Neil M O'Brien-Simpson, Eric C Reynolds

Journal article  |  2020  |  Cytokine

AIM: T helper (Th)17 cells are implicated in the pathogenesis of periodontitis. This study investigated the effect of periodontal ..

Peptides in Oral and Dental Research

Neil O'Brien-Simpson

Journal article  |  2020  |  International Journal of Peptide Research and Therapeutics

Peripheral neutrophil phenotypes during management of periodontitis

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Eric C Reynolds, Neil M O'Brien-Simpson, Ivan B Darby

Journal article  |  2020  |  Journal of Periodontal Research

BACKGROUND AND OBJECTIVES: Neutrophils are emerging as a key player in periodontal pathogenesis. The surface expression of cellula..

Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids.

Alicia Rasines Mazo, Stephanie Allison-Logan, Fatemeh Karimi, Nicholas Jun-An Chan, Wenlian Qiu, Wei Duan, Neil M O'Brien-Simpson, Greg G Qiao

Journal article  |  2020  |  Chemical Society Reviews

Polypeptides have attracted considerable attention in recent decades due to their inherent biodegradability and tunable cytocompat..

Enhanced Antibacterial Activity of Se Nanoparticles Upon Coating with Recombinant Spider Silk Protein eADF4(kappa 16)

Tao Huang, Sushma Kumari, Heike Herold, Hendrik Bargel, Tamara B Aigner, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor, Thomas Scheibel

Journal article  |  2020  |  International Journal of Nanomedicine

Purpose: Selenium nanoparticles (Se NPs) are promising antibacterial agents to tackle the growing problem of antimicrobial resista..