Neil O'Brien-Simpson

Retro Diels-Alder Fragmentation of Fulvene-Maleimide Bioconjugates for Mass Spectrometric Detection of Biomolecules.

Katherine G Stevens, Lewis O McFarlane, Kirsten Platts, Neil O'Brien-Simpson, Wenyi Li, Anton Blencowe, Paul J Trim, Tara L Pukala

Journal article  |  2021  |  Anal Chem

Diels-Alder chemistry is a well-explored avenue for the synthesis of bioactive materials; however, its potential applications have..

Pentafulvene-Maleimide Cycloaddition for Bioorthogonal Ligation

Kirsten Platts, Robert Michel, Elise Green, Todd Gillam, Maulik Ghetia, Neil O'Brien-Simpson, Wenyi Li, Christopher Blencowe, Anton Blencowe

Journal article  |  2021  |  BIOCONJUGATE CHEMISTRY

The applications of bioconjugation chemistry are rapidly expanding, and the addition of new strategies to the bioconjugation and l..

Chemically modified and conjugated antimicrobial peptides against superbugs

Wenyi Li, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

Journal article  |  2021  |  CHEMICAL SOCIETY REVIEWS

Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050, will lead to more deaths from bacteri..

Recent Applications of Aggregation Induced Emission Probes for Antimicrobial Peptide Studies

Tracey Luu, Wenyi Li, Neil M O'Brien-Simpson, Yuning Hong

Journal article  |  2021  |  CHEMISTRY-AN ASIAN JOURNAL

Antimicrobial peptides (AMPs) are being intensively investigated as they are considered promising alternatives to antibiotics wher..

Human glucose-dependent insulinotropic polypeptide (GIP) is an antimicrobial adjuvant re-sensitising multidrug-resistant Gram-negative bacteria

Da'san MM Jaradat, Nehaya Al-Karablieh, Basmah HM Zaarer, Wenyi Li, Khalil KY Saleh, Anas J Rasras, Saeid Abu-Romman, Neil M O'Brien-Simpson, John D Wade

Journal article  |  2021  |  BIOLOGICAL CHEMISTRY

Increasing antibiotic resistance in Gram-negative bacteria has mandated the development of both novel antibiotics and alternative ..

A review of T helper 17 cell-related cytokines in serum and saliva in periodontitis

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson

Journal article  |  2021  |  CYTOKINE

Periodontitis is a chronic inflammatory disease with a complex underlying immunopathology. Cytokines, as molecular mediators of in..

Bugs and Brains, the Gut and Mental Health Study: a mixed-methods study investigating microbiota composition and function in anxiety, depression and irritable bowel syndrome

Carra A Simpson, Orli S Schwartz, Djamila Eliby, Catherine A Butler, Katherine Huang, Neil O'Brien-Simpson, Bridget L Callaghan, Stuart G Dashper, Paul R Gooley, Sarah Whittle, Nick Haslam, Julian G Simmons

Journal article  |  2021  |  BMJ OPEN

INTRODUCTION: Research has highlighted relationships between the micro-organisms that inhabit our gastrointestinal tract (oral and..

Multifunctional Antimicrobial Polypeptide-Selenium Nanoparticles Combat Drug-Resistant Bacteria

Tao Huang, James A Holden, Eric C Reynolds, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

Journal article  |  2020  |  ACS APPLIED MATERIALS & INTERFACES

Antibiotic-resistant bacteria are a severe threat to human health. The World Health Organization's Global Antimicrobial Surveillan..

(Re)Defining the Proline-Rich Antimicrobial Peptide Family and the Identification of Putative New Members

Nicholas G Welch, Wenyi Li, Mohammed Akhter Hossain, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

Journal article  |  2020  |  FRONTIERS IN CHEMISTRY

As we rapidly approach a post-antibiotic era in which multi-drug resistant bacteria are ever-pervasive, antimicrobial peptides (AM..

Peripheral memory T-cell profile is modified in patients undergoing periodontal management

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, James A Holden, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson

Journal article  |  2020  |  JOURNAL OF CLINICAL PERIODONTOLOGY

AIMS: T-cells are known to have a role in periodontitis, however, the effect of periodontal therapy on peripheral memory T-cells i..