Neil O'Brien-Simpson

Using inorganic nanoparticles to fight fungal infections in the antimicrobial resistant era.

Tao Huang, Xin Li, Michael Maier, Neil M O'Brien-Simpson, Daniel E Heath, Andrea J O'Connor

Journal article  |  2023  |  Acta Biomater

Fungal infections pose a serious threat to human health and livelihoods. The number and variety of clinically approved antifungal ..

The effect of tailing lipidation on the bioactivity of antimicrobial peptides and their aggregation tendency Special Issue: Emerging Investigators

Bruce Lin, Andrew Hung, William Singleton, Kevion K Darmawan, Rachael Moses, Bicheng Yao, Hongkang Wu, Anders Barlow, Sani Marc-Antoine, Alastair J Sloan, Mohammed Akhter Hossain, John D Wade, Yuning Hong, Neil M O'Brien-Simpson, Wenyi Li

Journal article  |  2023  |  AGGREGATE

Bacteroides fragilis outer membrane vesicles preferentially activate innate immune receptors compared to their parent bacteria

William JJ Gilmore, Ella LL Johnston, Natalie JJ Bitto, Lauren Zavan, Neil O'Brien-Simpson, Andrewv FF Hill, Maria Kaparakis-Liaskos

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

The release of bacterial membrane vesicles (BMVs) has become recognized as a key mechanism used by both pathogenic and commensal b..

The 'Danse Macabre'-Neutrophils the Interactive Partner Affecting Oral Cancer Outcomes

Sara Hadjigol, Bansari A Shah, Neil M O'Brien-Simpson

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Over the past few decades, tremendous advances in the prevention, diagnosis, and treatment of cancer have taken place. However for..

Star-Peptide Polymers are Multi-Drug-Resistant Gram-Positive Bacteria Killers

Wenyi Li, Sara Hadjigol, Alicia Rasines Mazo, James Holden, Jason Lenzo, Steven J Shirbin, Anders Barlow, Sadegh Shabani, Tao Huang, Eric C Reynolds, Greg G Qiao, Neil M O'Brien-Simpson

Journal article  |  2022  |  ACS APPLIED MATERIALS & INTERFACES

Antibiotic resistance in bacteria, especially Gram-positive bacteria like Staphylococcus aureus, is gaining considerable momentum ..

Evaluation of Potential DnaK Modulating Proline-Rich Antimicrobial Peptides Identified by Computational Screening

Thomas NG Handley, Wenyi Li, Nicholas G Welch, Neil M O'Brien-Simpson, Mohammed Akhter Hossain, John D Wade

Journal article  |  2022  |  FRONTIERS IN CHEMISTRY

The day is rapidly approaching where current antibiotic therapies will no longer be effective due to the development of multi-drug..

Development and application of Diels-Alder adducts displaying AIE properties

Timothy L Gialelis, Tze Cin Owyong, Siyang Ding, Wenyi Li, Maoxing Yu, Neil M O'Brien-Simpson, Zujin Zhao, Jonathan M White, Bicheng Yao, Yuning Hong

Journal article  |  2022  |  CELL REPORTS PHYSICAL SCIENCE

Exploring organic reactions to construct novel molecules with aggregation-induced emission (AIE) features is an essential branch o..

Enhancing proline-rich antimicrobial peptide action by homodimerization: influence of bifunctional linker

Wenyi Li, Feng Lin, Andrew Hung, Anders Barlow, Marc-Antoine Sani, Rita Paolini, William Singleton, James Holden, Mohammed Akhter Hossain, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

Journal article  |  2022  |  CHEMICAL SCIENCE

Antimicrobial peptides (AMPs) are host defense peptides, and unlike conventional antibiotics, they possess potent broad spectrum a..

Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens

Bruce Lin, Andrew Hung, Rong Li, Anders Barlow, William Singleton, Tamara Matthyssen, Marc-Antoine D Sani, Mohammed Akhter Hossain, John Wade, Neil M O'Brien-Simpson, Wenyi Li

Journal article  |  2022  |  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The World Health Organisation has deemed several multi-drug resistant (MDR) nosocomial bacterial pathogens to be of significant th..

The Potential of Modified and Multimeric Antimicrobial Peptide Materials as Superbug Killers

Tamara Matthyssen, Wenyi Li, James A Holden, Jason C Lenzo, Sara Hadjigol, Neil M O'Brien-Simpson

Journal article  |  2022  |  FRONTIERS IN CHEMISTRY

Antimicrobial peptides (AMPs) are found in nearly all living organisms, show broad spectrum antibacterial activity, and can modula..