Dick Strugnell

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.

Andre Mu, William P Klare, Sarah L Baines, CN Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D Shah, Nitika Neha, et al.

Journal article  |  2023  |  Nat Commun

Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20-40%, w..

LPS O Antigen Plays a Key Role in Klebsiella pneumoniae Capsule Retention

Shweta Singh, Jonathan J Wilksch, Rhys A Dunstan, Anna Mularski, Nancy Wang, Dianna Hocking, Leila Jebeli, Hanwei Cao, Abigail Clements, Adam WJ Jenney, Trevor Lithgow, Richard A Strugnell

Journal article  |  2022  |  MICROBIOLOGY SPECTRUM

Despite the importance of encapsulation in bacterial pathogenesis, the biochemical mechanisms and forces that underpin retention o..

Genomic epidemiology of Salmonella Typhi in Central Division, Fiji, 2012 to 2016

Mark R Davies, Sebastian Duchene, Mary Valcanis, Aaron P Jenkins, Adam Jenney, Varanisese Rosa, Andrew J Hayes, Aneley Getahun Strobel, Liam McIntyre, Jake A Lacey, Elizabeth J Klemm, Vanessa K Wong, Aalisha Sahukhan, Helen Thomson, Andrew Page, Dianna Hocking, Nancy Wang, Litia Tudravu, Eric Rafai, Gordon Dougan, et al.

Journal article  |  2022  |  LANCET REGIONAL HEALTH-WESTERN PACIFIC

BACKGROUND: Typhoid fever is endemic in some Pacific Island Countries including Fiji and Samoa yet genomic surveillance is not rou..

Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen

Claire L Gorrie, Mirjana Mirceta, Ryan R Wick, Louise M Judd, Margaret MC Lam, Ryota Gomi, Iain J Abbott, Nicholas R Thomson, Richard A Strugnell, Nigel F Pratt, Jill S Garlick, Kerrie M Watson, Peter C Hunter, David V Pilcher, Steve A McGloughlin, Denis W Spelman, Kelly L Wyres, Adam WJ Jenney, Kathryn E Holt

Journal article  |  2022  |  NATURE COMMUNICATIONS

Klebsiella pneumoniae is a major cause of opportunistic healthcare-associated infections, which are increasingly complicated by th..

The Role of ZntA in Klebsiella pneumoniae Zinc Homeostasis

Eve A Maunders, Katherine Ganio, Andrew J Hayes, Stephanie L Neville, Mark R Davies, Richard A Strugnell, Christopher A McDevitt, Aimee Tan

Journal article  |  2022  |  MICROBIOLOGY SPECTRUM

Klebsiella pneumoniae is an opportunistic Gram-negative pathogen that is a leading cause of healthcare-associated infections, incl..

Assessment of Rapid Diagnostic Tests for Typhoid Diagnosis and Assessment of Febrile Illness Outbreaks in Fiji

Aneley Getahun Strobel, Stephanie Airs, Cattram Nguyen, Taina Rokobuli Vadei, Silivia Matanitobua, Mike Kama, Conall H Watson, John A Crump, E Kim Mulholland, Richard A Strugnell, Christopher M Parry

Journal article  |  2022  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Typhoid is an endemic in Fiji with increases observed since the early 2000s and frequent outbreaks reported. We assessed the diagn..

When secretion turns into excretion - the different roles of IgA.

Richard A Strugnell

Journal article  |  2022  |  Front Immunol

IgA deficiency is the commonest immunodeficiency affecting up to 1 in 700 individuals. The effects of IgA deficiency are difficult..

COVID-19 in Fiji

Patrick C Reading, Richard A Strugnell

Journal article  |  2021  |  MICROBIOLOGY AUSTRALIA

With the implementation of strict quarantine and adjunct health measures, Fiji was largely spared from the COVID-19 pandemic in 20..

Why predicting secreted effectors and what they do is important Comment on "An elegant nano-injection machinery for sabotaging the host: Role of Type III secretion systems in virulence of different human and animal pathogenic bacteria" by Hajra, Nair and Chakravortty

Richard Strugnell, Trevor Lithgow

Journal article  |  2021  |  PHYSICS OF LIFE REVIEWS

CD4( ) T cell immunity to Salmonella is transient in the circulation

Newton G Peres, Nancy Wang, Paul Whitney, Sven Engel, Meghanashree M Shreenivas, Ian Comerford, Dianna M Hocking, Anna B Erazo, Irmgard Foerster, Andreas Kupz, Thomas Gebhardt, Shaun R McColl, Stephen J McSorley, Sammy Bedoui, Richard A Strugnell

Journal article  |  2021  |  PLOS PATHOGENS

While Salmonella enterica is seen as an archetypal facultative intracellular bacterial pathogen where protection is mediated by CD..