Dick Strugnell

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  Immunity

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..

Pandemic printing: a novel 3D-printed swab for detecting SARS-CoV-2

Eloise Williams, Katherine Bond, Nicole Isles, Brian Chong, Douglas Johnson, Julian Druce, Tuyet Hoang, Susan A Ballard, Victoria Hall, Stephen Muhi, Kirsty L Buising, Seok Lim, Dick Strugnell, Mike Catton, Louis B Irving, Benjamin P Howden, Eric Bert, Deborah A Williamson

Journal article  |  2020  |  Medical Journal of Australia

OBJECTIVES: To design and evaluate 3D-printed nasal swabs for collection of samples for SARS-CoV-2 testing. DESIGN: An iterative d..

Comprehensive analysis of IncC plasmid conjugation identifies a crucial role for the transcriptional regulator AcaB

Steven J Hancock, Phan Minh-Duy, Zhenyao Luo, Alvin W Lo, Kate M Peters, Thi Khanh Nhu Nguyen, Brian M Forde, Jason Whitfield, Ji Yang, Richard A Strugnell, David L Paterson, Timothy R Walsh, Bostjan Kobe, Scott A Beatson, Mark A Schembri

Journal article  |  2020  |  Nature Microbiology

Global Trends in Proteome Remodeling of the Outer Membrane Modulate Antimicrobial Permeability in Klebsiella pneumoniae

Andrea Rocker, Jake A Lacey, Matthew J Belousoff, Jonathan J Wilkscha, Richard A Strugnell, Mark R Davies, Trevor Lithgow

Journal article  |  2020  |  mBio

In Gram-negative bacteria, the permeability of the outer membrane governs rates of antibiotic uptake and thus the efficacy of anti..

A retrospective study of patients with blood culture-confirmed typhoid fever in Fiji during 2014-2015: epidemiology, clinical features, treatment and outcome

Aneley Getahun, Christopher M Parry, John A Crump, Varanisese Rosa, Adam Jenney, Ravi Naidu, Kim Mulholland, Richard A Strugnell

Journal article  |  2019  |  Transactions of the Royal Society of Tropical Medicine and Hygiene

BACKGROUND: Typhoid fever is endemic in Fiji. We sought to describe the epidemiology, clinical features and case fatality risk of ..

Characterization and Purification of Mouse Mucosal-Associated Invariant T (MAIT) Cells.

Zhenjun Chen, Huimeng Wang, Criselle D'Souza, Hui-Fern Koay, Bronwyn Meehan, Zhe Zhao, Troi Pediongco, Mai Shi, Tianyuan Zhu, Bingjie Wang, Lars Kjer-Nielsen, Sidonia BG Eckle, Jamie Rossjohn, David P Fairlie, Dale I Godfrey, Richard A Strugnell, James McCluskey, Alexandra J Corbett

Journal article  |  2019  |  Current Protocols in Immunology

This unit describes the utility of various mouse models of infection and immunization for studying mucosal-associated invariant T ..

Loss of O-Linked Protein Glycosylation in Burkholderia cenocepacia Impairs Biofilm Formation and Siderophore Activity and Alters Transcriptional Regulators

Cameron C Oppy, Leila Jebeli, Miku Kuba, Clare V Oates, Richard Strugnell, Laura E Edgington-Mitchell, Miguel A Valvano, Elizabeth L Hartland, Hayley J Newton, Nichollas E Scott

Journal article  |  2019  |  mSphere

O-linked protein glycosylation is a conserved feature of the Burkholderia genus. The addition of the trisaccharide β-Gal-(1,3)-α-G..

IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection

Huimeng Wang, Lars Kjer-Nielsen, Mai Shi, Criselle D'Souza, Troi J Pediongco, Hanwei Cao, Lyudmila Kostenko, Xin Yi Lim, Sidonia BG Eckle, Bronwyn S Meehan, Tianyuan Zhu, Bingjie Wang, Zhe Zhao, Jeffrey YW Mak, David P Fairlie, Michele WL Teng, Jamie Rossjohn, Di Yu, Barbara Fazekas de St Groth, George Lovrecz, et al.

Journal article  |  2019  |  Science Immunology

Mucosal-associated invariant T (MAIT) cells are activated in a TCR-dependent manner by antigens derived from the riboflavin synthe..

The multifunctional enzyme S-adenosylhomocysteine/methylthioadenosine nucleosidase is a key metabolic enzyme in the virulence of Salmonella enterica var Typhimurium

Asma U Husna, Nancy Wang, Jonathan J Wilksch, Hayley J Newton, Dianna M Hocking, Iain D Hay, Simon A Cobbold, Mark R Davies, Malcolm J McConville, Trevor Lithgow, Richard A Strugnell

Journal article  |  2019  |  Biochemical Journal

Key physiological differences between bacterial and mammalian metabolism provide opportunities for the development of novel antimi..

The flagellotropic bacteriophage YSD1 targets Salmonella Typhi with a Chi-like protein tail fibre

Rhys A Dunstan, Derek Pickard, Sam Dougan, David Goulding, Claire Cormie, Joshua Hardy, Fuyi Li, Rhys Grinter, Katherine Harcourt, Lu Yu, Jiangning Song, Fernanda Schreiber, Jyoti Choudhary, Simon Clare, Fasseli Coulibaly, Richard A Strugnell, Gordon Dougan, Trevor Lithgow

Journal article  |  2019  |  Molecular Microbiology