David Packham

Effect of bardoxolone methyl on the urine albumin-to-creatinine ratio in patients with type 2 diabetes and stage 4 chronic kidney disease

Peter Rossing, Geoffrey A Block, Melanie P Chin, Angie Goldsberry, Hiddo JL Heerspink, Peter A McCullough, Colin J Meyer, David Packham, Pablo E Pergola, Bruce Spinowitz, Stuart M Sprague, David G Warnock, Glenn M Chertow

Journal article  |  2019  |  Kidney International

Sodium Zirconium Cyclosilicate among Individuals with Hyperkalemia A 12-Month Phase 3 Study

Bruce S Spinowitz, Steven Fishbane, Pablo E Pergola, Simon D Roger, Edgar V Lerma, Javed Butler, Stephan von Haehling, Scott H Adler, June Zhao, Bhupinder Singh, Philip T Lavin, Peter A McCullough, Mikhail Kosiborod, David K Packham

Journal article  |  2019  |  Clinical Journal of the American Society of Nephrology

BACKGROUND AND OBJECTIVES: Oral sodium zirconium cyclosilicate (formerly ZS-9) binds and removes potassium via the gastrointestina..

Efficacy and Safety of Sodium Zirconium Cyclosilicate for Treatment of Hyperkalemia: An 11-Month Open-Label Extension of HARMONIZE.

Simon D Roger, Bruce S Spinowitz, Edgar V Lerma, Bhupinder Singh, David K Packham, Ayman Al-Shurbaji, Mikhail Kosiborod

Journal article  |  2019  |  American Journal of Nephrology

BACKGROUND: Sodium zirconium cyclosilicate (SZC; formerly ZS-9) is a selective potassium (K+) binder for treatment of hyperkalemia..

Allogeneic Mesenchymal Precursor Cells (MPC) in Diabetic Nephropathy: A Randomized, Placebo-controlled, Dose Escalation Study

David K Packham, Ian R Fraser, Peter G Kerr, Karen R Segal

Journal article  |  2016  |  EBioMedicine

Individual long-term albuminuria exposure during angiotensin receptor blocker therapy is the optimal predictor for renal outcome

Tobias Felix Kropelin, Dick de Zeeuw, Frank Arjan Holtkamp, David Kenneth Packham, Hiddo JL Heerspink

Journal article  |  2016  |  Nephrology Dialysis Transplantation

A Novel Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial

Richard A Brigandi, Brendan Johnson, Coreen Oei, Mark Westerman, Gordana Olbina, Janak de Zoysa, Simon D Roger, Manisha Sahay, Nicholas Cross, Lawrence McMahon, Veerabhadra Guptha, Elena A Smolyarchuk, Narinder Singh, Steven F Russ, Sanjay Kumar

Journal article  |  2016  |  American Journal of Kidney Diseases

Pharmacodynamics and pharmacokinetics of sodium zirconium cyclosilicate [ZS-9] in the treatment of hyperkalemia

David K Packham, Mikhail Kosiborod

Journal article  |  2016  |  Expert Opinion on Drug Metabolism & Toxicology

Potential New Agents for the Management of Hyperkalemia

David K Packham, Mikhail Kosiborod

Journal article  |  2016  |  American Journal of Cardiovascular Drugs

Sodium zirconium cyclosilicate for urgent therapy of severe hyperkalemia.

Mikhail Kosiborod, W Frank Peacock, David K Packham

Journal article  |  2015  |  New England Journal of Medicine

New Agents for Hyperkalemia REPLY

David K Packham, Henrik S Rasmussen, Bhupinder Singh

Journal article  |  2015  |  New England Journal of Medicine

Sodium Zirconium Cyclosilicate in Hyperkalemia

David K Packham, Henrik S Rasmussen, Philip T Lavin, Mohamed A El-Shahawy, Simon D Roger, Geoffrey Block, Wajeh Qunibi, Pablo Pergola, Bhupinder Singh

Journal article  |  2015  |  New England Journal of Medicine

Pyridoxamine Dihydrochloride in Diabetic Nephropathy (PIONEER-CSG-17): Lessons Learned from a Pilot Study

Jamie P Dwyer, Barbara A Greco, Kausik Umanath, David Packham, J Wesley Fox, Robert Peterson, Benjamin R Broome, Laura E Greene, Mohammed Sika, Julia B Lewis

Journal article  |  2015  |  Nephron

Effect of Sodium Zirconium Cyclosilicate on Potassium Lowering for 28 Days Among Outpatients With Hyperkalemia The HARMONIZE Randomized Clinical Trial

Mikhail Kosiborod, Henrik S Rasmussen, Philip Lavin, Wajeh Y Qunibi, Bruce Spinowitz, David Packham, Simon D Roger, Alex Yang, Edgar Lerma, Bhupinder Singh

Journal article  |  2014  |  JAMA

Mechanisms Contributing to Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated with Bardoxolone Methyl

Melanie P Chin, Scott A Reisman, George L Bakris, Megan O'Grady, Peter G Linde, Peter A McCullough, David Packham, Nosratola D Vaziri, Keith W Ward, David G Warnock, Colin J Meyer

Journal article  |  2014  |  American Journal of Nephrology

Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease

D De Zeeuw, T Akizawa, P Audhya, GL Bakris, M Chin, H Christ-Schmidt, A Goldsberry, M Houser, M Krauth, HJ Lambers Heerspink, JJ McMurray, CJ Meyer, HH Parving, G Remuzzi, RD Toto, ND Vaziri, C Wanner, J Wittes, D Wrolstad, GM Chertow, et al.

Journal article  |  2013  |  New England Journal of Medicine

Vitamin D reduces left atrial volume in patients with left ventricular hypertrophy and chronic kidney disease

Hector Tamez, Carmine Zoccali, David Packham, Julia Wenger, Ishir Bhan, Evan Appelbaum, Yili Pritchett, Yuchiao Chang, Rajiv Agarwal, Christoph Wanner, Donald Lloyd-Jones, Jorge Cannata, B Taylor Thompson, Dennis Andress, Wuyan Zhang, Bhupinder Singh, Daniel Zehnder, Ajay Pachika, Warren J Manning, Amil Shah, et al.

Journal article  |  2012  |  American Heart Journal

Vitamin D Therapy and Cardiac Structure and Function in Patients With Chronic Kidney Disease The PRIMO Randomized Controlled Trial

Ravi Thadhani, Evan Appelbaum, Yili Pritchett, Yuchiao Chang, Julia Wenger, Hector Tamez, Ishir Bhan, Rajiv Agarwal, Carmine Zoccali, Christoph Wanner, Donald Lloyd-Jones, Jorge Cannata, B Taylor Thompson, Dennis Andress, Wuyan Zhang, David Packham, Bhupinder Singh, Daniel Zehnder, Amil Shah, Ajay Pachika, et al.

Journal article  |  2012  |  JAMA

Pyridorin in Type 2 Diabetic Nephropathy

Edmund J Lewis, Tom Greene, Samuel Spitalewiz, Samuel Blumenthal, Tomas Berl, Lawrence G Hunsicker, Marc A Pohl, Richard D Rohde, Itamar Raz, Yair Yerushalmy, Yoram Yagil, Tommy Herskovits, Robert C Atkins, Anne T Reutens, David K Packham, Julia B Lewis

Journal article  |  2012  |  Journal of the American Society of Nephrology

Relative Incidence of ESRD Versus Cardiovascular Mortality in Proteinuric Type 2 Diabetes and Nephropathy: Results From the DIAMETRIC (Diabetes Mellitus Treatment for Renal Insufficiency Consortium) Database

David K Packham, Tahira P Alves, Jamie P Dwyer, Robert Atkins, Dick de Zeeuw, Mark Cooper, Shahnaz Shahinfar, Julia B Lewis, Hiddo J Lambers Heerspink

Journal article  |  2012  |  American Journal of Kidney Diseases

Sulodexide Fails to Demonstrate Renoprotection in Overt Type 2 Diabetic Nephropathy

David K Packham, Rory Wolfe, Anne T Reutens, Tomas Berl, Hiddo Lambers Heerspink, Richard Rohde, Sara Ivory, Julia Lewis, Itamar Raz, Thomas B Wiegmann, Juliana CN Chan, Dick de Zeeuw, Edmund J Lewis, Robert C Atkins

Journal article  |  2012  |  Journal of the American Society of Nephrology

Vitamin D Receptor Activation and Left Ventricular Hypertrophy in Advanced Kidney Disease

Ravi Thadhani, Evan Appelbaum, Yuchiao Chang, Yili Pritchett, Ishir Bhan, Rajiv Agarwal, Carmine Zoccali, Christoph Wanner, Donald Lloyd-Jones, Jorge Cannata, Taylor Thompson, Paul Audhya, Dennis Andress, Wuyan Zhang, Jun Ye, David Packham, Bhupinder Singh, Daniel Zehnder, Warren J Manning, Ajay Pachika, et al.

Journal article  |  2011  |  American Journal of Nephrology

Study of Heart and Renal Protection (SHARP): randomized trial to assess the effects of lowering low-density lipoprotein cholesterol among 9,438 patients with chronic kidney disease.

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Journal article  |  2010  |  American Heart Journal

BACKGROUND: Lowering low-density lipoprotein (LDL) cholesterol with statin therapy has been shown to reduce the incidence of ather..

Effect of pravastatin on kidney function and urinary protein excretion in autosomal dominant polycystic kidney disease.

Robert G Fassett, Jeff S Coombes, David Packham, Kenneth F Fairley, Priscilla Kincaid-Smith

Journal article  |  2010  |  Scandinavian Journal of Urology and Nephrology

OBJECTIVE: Autosomal dominant polycystic kidney disease (ADPKD) is progressive, resulting in end-stage kidney failure in most pati..

Rationale for and study design of the sulodexide trials in Type 2 diabetic, hypertensive patients with microalbuminuria or overt nephropathy.

HJ Lambers Heerspink, MJ Fowler, J Volgi, AT Reutens, I Klein, TA Herskovits, DK Packham, IR Fraser, SL Schwartz, C Abaterusso, J Lewis, undefined Collaborative Study Group

Journal article  |  2007  |  Diabetic Medicine

BACKGROUND: Patients with Type 2 diabetes and albuminuria are at high risk to progress to end-stage renal disease (ESRD). Although..

Thin basement membrane nephropathy and IgA glomerulonephritis: can they be distinguished without renal biopsy?

David K Packham

Journal article  |  2007  |  Nephrology

BACKGROUND: Thin basement membrane nephropathy (TBMN) and IgA glomerulonephritis (IgA gn) are the most common primary glomerular c..

Systemic and vascular inflammation is elevated in early IgA and type 1 diabetic nephropathies and relates to vascular disease risk factors and renal function

CL Nelson, CS Karschimkus, G Dragicevic, DK Packham, AM Wilson, D O'Neal, GJ Becker, JD Best, AJ Jenkins

Journal article  |  2005  |  Nephrology, Dialysis, Transplantation

Hematuria in thin basement membrane nephropathy

DK Packham, V Perkovic, J Savige, MRA Broome

Journal article  |  2005  |  Seminars in Nephrology

Thin basement membrane nephropathy in pregnancy.

David Packham

Journal article  |  2005  |  Seminars in Nephrology

There are several published series of pregnancy in patients with nonimmunoglobulin A mesangial proliferative glomerulonephritis (m..

Dual blockade of the renin-angiotensin system compared with a 50% increase in the dose of angiotensin-converting enzyme inhibitor: effects on proteinuria and blood pressure.

Priscilla Kincaid-Smith, Kenneth F Fairley, David Packham

Journal article  |  2004  |  Nephrology Dialysis Transplantation

BACKGROUND: Several publications in the past 2 years have demonstrated that combined angiotensin-converting enzyme inhibitors (ACE..

Erratum: Randomized controlled crossover study of the effect on proteinuria and blood pressure of adding an angiotensin II receptor antagonist to an angiotensin converting enzyme inhibitor in normotensive patients with chronic renal disease and proteinuria (Nephrology Dialysis Transplantation (2001) vol. 17 (597-601))

P Kincaid-Smith, K Fairley, D Packham

Journal article  |  2002  |  Nephrology Dialysis Transplantation

Randomized controlled crossover study of the effect on proteinuria and blood pressure of adding an angiotensin II receptor antagonist to an angiotensin converting enzyme inhibitor in normotensive patients with chronic renal disease and proteinuria.

Priscilla Kincaid-Smith, Kenneth Fairley, David Packham

Journal article  |  2002  |  Nephrology Dialysis Transplantation

BACKGROUND: Proteinuria and hypertension have independent deleterious effects on the progression of chronic renal disease. The obj..

Response to parathyroidectomy at the axial and appendicular skeleton in renal patients

MS Stein, DK Packham, JD Wark, GJ Becker

Journal article  |  1999  |  Clinical Nephrology

Lambda light chain induced nephropathy: a rare cause of the Fanconi syndrome and severe osteomalacia.

KL Bate, D Clouston, D Packham, S Ratnaike, PR Ebeling

Journal article  |  1998  |  American Journal of Kidney Diseases

The Fanconi syndrome is a generalized disorder of proximal renal tubular transport characterized by wasting of phosphate, amino ac..

Large, rapid skeletal changes after parathyroidectomy

MS Stein, DK Packham, JD Wark, PR Ebeling, GJ Becker

Journal article  |  1997  |  Clinical Nephrology

Prognosis in IgA nephropathy

D Packham

Journal article  |  1997  |  Nephrology

Prevalence and risk factors for osteopenia in dialysis patients

MS Stein, DK Packham, PR Ebeling, JD Wark, GJ Becker

Journal article  |  1996  |  American Journal of Kidney Diseases

The significance of focal and segmental hyalinosis and sclerosis (FSHS) and nephrotic range proteinuria in IgA nephropathy

DK Packham, HD Yan, TD Hewitson, KM Nicholls, KF Fairley, P KincaidSmith, GJ Becker

Journal article  |  1996  |  Clinical Nephrology

ACUTE-RENAL-FAILURE IN IGA NEPHROPATHY

DK PACKHAM, TD HEWITSON, HD YAN, CE ELLIOTT, K NICHOLLS, GJ BECKER

Journal article  |  1994  |  Clinical Nephrology

Pregnancy-related complications in women with reflux nephropathy

M El-Khatib, DK Packham, GJ Becker, P Kincaid-Smith

Journal article  |  1994  |  Obstetrical and Gynecological Survey

Pregnancy-related complications in women with reflux nephropathy.

M el-Khatib, DK Packham, GJ Becker, P Kincaid-Smith

Journal article  |  1994  |  Clinical Nephrology

Three hundred and forty-five pregnancies in 137 women with reflux nephropathy have been studied. All pregnancies took place after ..

Aspects of renal disease and pregnancy.

DK Packham

Conference Proceedings  |  1993  |  Kidney International, Supplement

GLOMERULOSCLEROSIS AND HYALINOSIS IN RABBITS

DK PACKHAM, TD HEWITSON, JA WHITWORTH, PS KINCAIDSMITH

Journal article  |  1992  |  Pathology

LUPUS NEPHRITIS AND PREGNANCY

DK PACKHAM, SS LAM, K NICHOLLS, KF FAIRLEY, PS KINCAIDSMITH

Journal article  |  1992  |  QJM: An International Journal of Medicine

Pregnancy in membranous glomerulonephritis.

P Kincaid-Smith, K Fairley, D Packham

Conference Proceedings  |  1992  |  Nephrology Dialysis Transplantation

Pregnancy in women with focal hyalinosis and sclerosis.

Z Eren, T Dönmez, O Paşaoğlu, I Dölen, E Erenoğlu

Journal article  |  1991  |  Clinical Nephrology

PHYSIOLOGICAL AND BIOCHEMICAL EFFECTS OF PREGNANCY IN UNINEPHRECTOMIZED RABBITS

DK PACKHAM, TD HEWITSON, JA WHITWORTH, PS KINCAIDSMITH

Journal article  |  1991  |  Clinical and Experimental Hypertension. Part B: Hypertension in Pregnancy

Primary glomerulonephritis and pregnancy.

DK Packham, RA North, KF Fairley, M Kloss, JA Whitworth, P Kincaid-Smith

Journal article  |  1989  |  QJM: An International Journal of Medicine

Three hundred and ninety-five pregnancies undertaken by 238 women with primary glomerulonephritis between 1962 and 1987 were analy..

Glomerular crescents and pregnancy.

CK Fairley, DK Packham

Journal article  |  1989  |  American Journal of Kidney Diseases

Morphometric analysis of preeclampsia in women biopsied in pregnancy and post-partum

DK Packham, DC Matthews, KF Fairley, JA Whitworth, PS Kincaid-Smith

Journal article  |  1989  |  Obstetrical & Gynecological Survey

Comparison of pregnancy outcome between normotensive and hypertensive women with primary glomerulonephritis

DK Packham, KF Fairley, BU Ihle, JA Whitworth, P Kincaid-Smith

Journal article  |  1989  |  Obstetrical & Gynecological Survey

Morphometric analysis of pre-eclampsia in women biopsied in pregnancy and post-partum.

DK Packham, DC Mathews, KF Fairley, JA Whitworth, PS Kincaid-Smith

Journal article  |  1988  |  Kidney International

The importance of endothelial cell swelling and subepithelial deposits in producing capillary wall thickening in women with pre-ec..

IgA glomerulonephritis and pregnancy.

DK Packham, RA North, KF Fairley, JA Whitworth, P Kincaid-Smith

Journal article  |  1988  |  Clinical Nephrology

One hundred and sixteen pregnancies in 70 women with a biopsy-proven diagnosis of IgA glomerulonephritis have been analysed. Thirt..

Histological features of IgA glomerulonephritis as predictors of pregnancy outcome.

D Packham, JA Whitworth, KF Fairley, P Kincaid-Smith

Journal article  |  1988  |  Clinical Nephrology

116 pregnancies undertaken by 70 women with IgA glomerulonephritis and their diagnostic renal biopsies have been reviewed. An IgA ..

Pregnancy in women with diffuse mesangial proliferative glomerulonephritis.

DK Packham, RA North, KF Fairley, JA Whitworth, PR Lloren, E Lee, P Kincaid-Smith

Journal article  |  1988  |  Clinical Nephrology

The clinical course of 168 pregnancies in 91 women with non-IgA diffuse mesangial proliferative glomerulonephritis has been analyz..

Pregnancy in women with primary focal and segmental hyalinosis and sclerosis.

DK Packham, RA North, KF Fairley, BU Ihle, JA Whitworth, P Kincaid-Smith

Journal article  |  1988  |  Clinical Nephrology

Thirty-one pregnancies and post partum clinical course of 21 women with a diagnosis of primary focal and segmental hyalinosis and ..

Renal biopsy: Indications and complications in pregnancy

D Packham, KF Fairley

Journal article  |  1988  |  Obstetrical & Gynecological Survey

Membranous glomerulonephritis and pregnancy

DK Packham, RA North, KF Fairley, JA Zarrabiina, P Kincaidsmith

Journal article  |  1988  |  Obstetrical & Gynecological Survey

Renal biopsy: indications and complications in pregnancy.

D Packham, KF Fairley

Journal article  |  1987  |  BJOG: An International Journal of Obstetrics and Gynaecology

A series of 111 renal biopsies performed in 104 pregnant women during the past 20 years at The Royal Melbourne Hospital and Royal ..

Membranous glomerulonephritis and pregnancy.

DK Packham, RA North, KF Fairley, JA Whitworth, P Kincaid-Smith

Journal article  |  1987  |  Clinical Nephrology

The clinical courses of 33 pregnancies in 24 patients with biopsy proven membranous glomerulonephritis have been analyzed. Twenty-..

Comparison of pregnancy outcome between normotensive and hypertensive women with primary glomerulonephritis

DK Packham, KF Fairley, BU Ihle, JA Whitworth, P Kincaid-Smith

Journal article  |  1987  |  Clinical and Experimental Hypertension. Part B: Hypertension in Pregnancy

An assessment of the possible protective effect of allopurinol in acute stroke.

R Iansek, D Packham, BS Aspey, MJ Harrison

Journal article  |  1986  |  Journal of Neurology, Neurosurgery & Psychiatry

Allopurinol has been shown to have a protective effect on ischaemic tissue by the indirect prevention of excessive purine loss. Th..