Treve Menheniott

Coordinate expression loss of GKN1 and GKN2 in gastric cancer via impairment of a glucocorticoid-responsive enhancer

Sharleen Chung Nien Chin, Louise O'Connor, Michelle Scurr, Jonathan T Busada, Alison N Graham, Ghazal Alipour Talesh, Chau P Tran, Sohinee Sarkar, Toshinari Minamoto, Andrew S Giraud, John A Cidlowski, Philip Sutton, Trevelyan R Menheniott

Journal article  |  2020  |  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Gastrokines (GKNs) are anti-inflammatory proteins secreted by gastric epithelial (surface mucous and pit) cells, with their aberra..

Selective Persistence of HPV Cross-Neutralising Antibodies following Reduced-Dose HPV Vaccine Schedules

Zheng Quan Toh, Jennie Kosasih, Fiona M Russell, Rita Reyburn, James Fong, Evelyn Tuivaga, Felisita T Ratu, Cattram D Nguyen, Silivia Matanitobua, Lien Anh Ha Do, Trevelyan Menheniott, Ian H Frazer, Suzanne M Garland, Edward Kim Mulholland, Paul V Licciardi

Journal article  |  2019  |  VACCINES

The duration of cross-neutralising antibody responses (cross-NAb) following HPV immunisation is unknown. We compared cross-NAb res..

Postnatal inflammation following intrauterine inflammation exacerbates the development of atherosclerosis in ApoE(-/-) mice

Siroon Bekkering, Albert P Limawan, Maria U Nguyen, Lisa K Widiasmoko, Hui Lu, Salvatore Pepe, Michael M Cheung, Trevelyan R Menheniott, Megan J Wallace, David P Burgner, Timothy J Moss

Journal article  |  2019  |  CLINICAL SCIENCE

Atherosclerosis is a chronic inflammatory disease that has its origins in early life. Postnatal inflammation exacerbates atheroscl..

Overexpression of IL-11 promotes premalignant gastric epithelial hyperplasia in isolation from germline gp130-JAK-STAT driver mutations

Jon N Buzzelli, Louise O'Connor, Michelle Scurr, Sharleen Chung Nien Chin, Angelique Catubig, Garrett Z Ng, Masanobu Oshima, Hiroko Oshima, Andrew S Giraud, Philip Sutton, Louise M Judd, Trevelyan R Menheniott

Journal article  |  2019  |  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Expression of the cytokine IL-11 is elevated in human Helicobacter pylori infection and progressively increases with worsening gas..

The MUC1 mucin protects against Helicobacter pylori pathogenesis in mice by regulation of the NLRP3 inflammasome

Garrett Z Ng, Trevelyan R Menheniott, Alison L Every, Andrew Stent, Louise M Judd, Yok Teng Chionh, Poshmaal Dhar, Jasper C Komen, Andrew S Giraud, Timothy C Wang, Michael A McGuckin, Philip Sutton

Journal article  |  2016  |  GUT

OBJECTIVES: The mucin MUC1, best known for providing an epithelial barrier, is an important protective host factor in both humans ..

Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression

Trevelyan R Menheniott, Louise O'Connor, Yok Teng Chionh, Jan Daebritz, Michelle Scurr, Benjamin N Rollo, Garrett Z Ng, Shelley Jacobs, Angelique Catubig, Bayzar Kurklu, Stephen Mercer, Toshinari Minamoto, David E Ong, Richard L Ferrero, James G Fox, Timothy C Wang, Philip Sutton, Louise M Judd, Andrew S Giraud

Journal article  |  2016  |  JOURNAL OF CLINICAL INVESTIGATION

Chronic mucosal inflammation is associated with a greater risk of gastric cancer (GC) and, therefore, requires tight control by su..

Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells

Jan Daebritz, Louise M Judd, Heather V Chalinor, Trevelyan R Menheniott, Andrew S Giraud

Journal article  |  2016  |  SCIENTIFIC REPORTS

STAT3 regulates the expansion of myeloid-derived suppressor cells (MDSCs) during inflammation, infection and cancer. Hyperactivati..

Enteric Neural Cells From Hirschsprung Disase Patients Form Ganglia in Autologous Aneuronal Colon

Benjamin N Rollo, Dongcheng Zhang, Lincon A Stamp, Trevelyan R Menheniott, Lefteris Stathopoulos, Mark Denham, Mirella Dottori, Sebastian K King, John M Hutson, Donald F Newgreen

Journal article  |  2016  |  CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY

BACKGROUND & AIMS: Hirschsprung disease (HSCR) is caused by failure of cells derived from the neural crest (NC) to colonize the di..

Elevated IL-33 expression is associated with pediatric eosinophilic esophagitis, and exogenous IL-33 promotes eosinophilic esophagitis development in mice

LM Judd, RG Heine, TR Menheniott, J Buzzelli, N O'Brien-Simpson, D Pavlic, L O'Connor, K Al Gazali, O Hamilton, M Scurr, AM Collison, J Mattes, KJ Allen, AS Giraud

Journal article  |  2016  |  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

We tested whether the T helper (Th) type 2 (Th2) cell agonist and allergenic ligand IL-33 was associated with eosinophilic esophag..

STAT3: a critical component in the response to Helicobacter pylori infection

Trevelyan R Menheniott, Louise M Judd, Andrew S Giraud

Journal article  |  2015  |  CELLULAR MICROBIOLOGY

STAT3 imparts a profound influence on both the epithelial and immune components of the gastric mucosa, and through regulation of k..