David Howells

Acute Routine Leukocyte and Neutrophil Counts Are Predictive of Poststroke Recovery at 3 and 12 Months Poststroke: An Exploratory Study

Vinh A Nguyen, Sheila G Crewther, David W Howells, Tissa Wijeratne, Henry Ma, Graeme J Hankey, Stephen Davis, Geoffrey A Donnan, Leeanne M Carey

Journal article  |  2020  |  NEUROREHABILITATION AND NEURAL REPAIR

Background and Aims. White blood cell (WBC) and neutrophil counts (NC) are common markers of inflammation and neurological stroke ..

Longitudinal Stroke Recovery Associated With Dysregulation of Complement System-A Proteomics Pathway Analysis

Vinh A Nguyen, Nina Riddell, Sheila G Crewther, Pierre Faou, Harinda Rajapaksha, David W Howells, Graeme J Hankey, Tissa Wijeratne, Henry Ma, Stephen Davis, Geoffrey A Donnan, Leeanne M Carey

Journal article  |  2020  |  FRONTIERS IN NEUROLOGY

Currently the longitudinal proteomic profile of post-ischemic stroke recovery is relatively unknown with few well-accepted biomark..

Differential susceptibility of human neural progenitors and neurons to ischaemic injury

Ye Liu, Anna E Michalska, Mirella Dottori, Emma Eaton, Jo-Maree Courtney, Ana Antonic, David W Howells

Conference Proceedings  |  2020  |  BRAIN RESEARCH BULLETIN

BACKGROUND: Neuroprotection for stroke has shown great promise but has had little translational success. Developing drugs for huma..

Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores

Peter Goodin, Gemma Lamp, Rishma Vidyasagar, Alan Connelly, Stephen Rose, Bruce C Campbell, Tamara Tse, Henry Ma, David Howells, Graeme J Hankey, Stephen Davis, Geoffrey Donnan, Leeanne M Carey

Journal article  |  2019  |  NEURAL PLASTICITY

Background: One in three survivors of stroke experience poststroke depression (PSD). PSD has been linked with poorer recovery of f..

Human Ischaemic Cascade Studies Using SH-SY5Y Cells: a Systematic Review and Meta-Analysis

Ye Liu, Emma D Eaton, Taryn E Wills, Sarah K McCann, Ana Antonic, David W Howells

Journal article  |  2018  |  TRANSLATIONAL STROKE RESEARCH

Low translational yield for stroke may reflect the focus of discovery science on rodents rather than humans. Just how little is kn..

Hyperacute changes in blood mRNA expression profiles of rats after middle cerebral artery occlusion: Towards a stroke time signature

Marie Dagonnier, William John Wilson, Jenny Margaret Favaloro, Sarah Susan Jane Rewell, Linda Jane Lockett, Stephen Andrew Sastra, Amy Lucienne Jeffreys, Helen Margaret Dewey, Geoffrey Alan Donnan, David William Howells

Journal article  |  2018  |  PLOS ONE

Derivation of phenotypically diverse neural culture from hESC by combining adherent and dissociation methods

Ye Liu, Ana Antonic, Xuan Yang, Nils Korte, Katherine Lim, Anna E Michalska, Mirella Dottori, David W Howells

Journal article  |  2018  |  JOURNAL OF NEUROSCIENCE METHODS

BACKGROUND: Differentiation of human embryonic stem cells (hESCs) into distinct neural lineages has been widely studied. However, ..

NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons

Ana Antonic, Mirella Dottori, Malcolm R Macleod, Geoffrey A Donnan, David W Howells

Journal article  |  2018  |  JOURNAL OF STROKE & CEREBROVASCULAR DISEASES

BACKGROUND: Developing new medicines is a complex process where understanding the reasons for both failure and success takes us fo..

A complementary role for tetraspanin superfamily member TSSC6 and ADP purinergic P2Y(12) receptor in platelets

Mohammed Makkawi, David Howells, Mark D Wright, Denise E Jackson

Journal article  |  2018  |  THROMBOSIS RESEARCH

Tumor-suppressing subchromosomal transferable fragment cDNA 6 (TSSC6) expression is restricted to hematopoietic organs and tissues..

Hyperacute changes in blood mRNA expression profiles of rats after middle cerebral artery occlusion: Towards a stroke time signature.

Marie Dagonnier, William John Wilson, Jenny Margaret Favaloro, Sarah Susan Jane Rewell, Linda Jane Lockett, Stephen Andrew Sastra, Amy Lucienne Jeffreys, Helen Margaret Dewey, Geoffrey Alan Donnan, David William Howells

Journal article  |  2018  |  PLoS One

Stroke evolution is a highly dynamic but variable disease which makes clinical decision making difficult. Biomarker discovery prog..