David Howells

Differential susceptibility of human neural progenitors and neurons to ischaemic injury

Ye Liu, Anna E Michalska, Mirella Dottori, Emma Eaton, Jo-Maree Courtney, Ana Antonic, David W Howells

Conference Proceedings  |  2020  |  Brain Research Bulletin

Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores

Peter Goodin, Gemma Lamp, Rishma Vidyasagar, Alan Connelly, Stephen Rose, Bruce C Campbell, Tamara Tse, Henry Ma, David Howells, Graeme J Hankey, Stephen Davis, Geoffrey Donnan, Leeanne M Carey

Journal article  |  2019  |  Neural Plasticity

Human Ischaemic Cascade Studies Using SH-SY5Y Cells: a Systematic Review and Meta-Analysis

Ye Liu, Emma D Eaton, Taryn E Wills, Sarah K McCann, Ana Antonic, David W Howells

Journal article  |  2018  |  Translational Stroke Research

Hyperacute changes in blood mRNA expression profiles of rats after middle cerebral artery occlusion: Towards a stroke time signature

Marie Dagonnier, William John Wilson, Jenny Margaret Favaloro, Sarah Susan Jane Rewell, Linda Jane Lockett, Stephen Andrew Sastra, Amy Lucienne Jeffreys, Helen Margaret Dewey, Geoffrey Alan Donnan, David William Howells

Journal article  |  2018  |  PLOS ONE

Derivation of phenotypically diverse neural culture from hESC by combining adherent and dissociation methods

Ye Liu, Ana Antonic, Xuan Yang, Nils Korte, Katherine Lim, Anna E Michalska, Mirella Dottori, David W Howells

Journal article  |  2018  |  Journal of Neuroscience Methods

NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons

Ana Antonic, Mirella Dottori, Malcolm R Macleod, Geoffrey A Donnan, David W Howells

Journal article  |  2018  |  Journal of Stroke and Cerebrovascular Diseases

A complementary role for tetraspanin superfamily member TSSC6 and ADP purinergic P2Y(12) receptor in platelets

Mohammed Makkawi, David Howells, Mark D Wright, Denise E Jackson

Journal article  |  2018  |  Thrombosis Research

Hyperacute changes in blood mRNA expression profiles of rats after middle cerebral artery occlusion: Towards a stroke time signature.

Marie Dagonnier, William John Wilson, Jenny Margaret Favaloro, Sarah Susan Jane Rewell, Linda Jane Lockett, Stephen Andrew Sastra, Amy Lucienne Jeffreys, Helen Margaret Dewey, Geoffrey Alan Donnan, David William Howells

Journal article  |  2018  |  PLOS ONE

Stroke evolution is a highly dynamic but variable disease which makes clinical decision making difficult. Biomarker discovery prog..

Discovery and Longitudinal Evaluation of Candidate Biomarkers for Ischaemic Stroke by Mass Spectrometry-Based Proteomics

Marie Dagonnier, Ira Robin Cooke, Pierre Faou, Tara Kate Sidon, Helen Margaret Dewey, Geoffrey Alan Donnan, David William Howells

Journal article  |  2017  |  Biomarker Insights

Risk of bias reporting in the recent animal focal cerebral ischaemia literature.

Zsanett Bahor, Jing Liao, Malcolm R Macleod, Alexandra Bannach-Brown, Sarah K McCann, Kimberley E Wever, James Thomas, Thomas Ottavi, David W Howells, Andrew Rice, Sophia Ananiadou, Emily Sena

Journal article  |  2017  |  Clinical Science

BACKGROUND: Findings from in vivo research may be less reliable where studies do not report measures to reduce risks of bias. The ..

Hypothermia revisited: Impact of ischaemic duration and between experiment variability

Sarah SJ Rewell, Amy L Jeffreys, Steven A Sastra, Susan F Cox, John A Fernandez, Elena Aleksoska, H Bart van der Worp, Leonid Churilov, Malcolm R Macleod, David W Howells

Journal article  |  2017  |  Journal of Cerebral Blood Flow & Metabolism

Standardized mean differences cause funnel plot distortion in publication bias assessments.

Peter-Paul Zwetsloot, Mira Van Der Naald, Emily S Sena, David W Howells, Joanna IntHout, Joris Ah De Groot, Steven Aj Chamuleau, Malcolm R MacLeod, Kimberley E Wever

Journal article  |  2017  |  eLife

Meta-analyses are increasingly used for synthesis of evidence from biomedical research, and often include an assessment of publica..

Reduced bone formation markers, and altered trabecular and cortical bone mineral densities of non-paretic femurs observed in rats with ischemic stroke: A randomized controlled pilot study

Karen N Borschmann, Sarah S Rewell, Sandra Iuliano, Ali Ghasem-Zadeh, Rachel A Davey, Heidi Ho, Peta N Skeers, Julie Bernhardt, David W Howells

Journal article  |  2017  |  PLOS ONE

Evolution of ischemic damage and behavioural deficit over 6 months after MCAo in the rat: Selecting the optimal outcomes and statistical power for multi-centre preclinical trials

Sarah SJ Rewell, Leonid Churilov, T Kate Sidon, Elena Aleksoska, Susan F Cox, Malcolm R Macleod, David W Howells

Journal article  |  2017  |  PLOS ONE

Animal Models of Ischemic Stroke Versus Clinical Stroke: Comparison of Infarct Size, Cause, Location, Study Design, and Efficacy of Experimental Therapies

Victoria E O'Collins, Geoffrey A Donnan, Malcolm R Macleod, David W Howells

Book Chapter  |  2017

The Right Rodent for the Job: Infarct Variability Between Strains and Its Impact on Logistics of Experimental Animal Studies

Sarah Rewell, David W Howells

Book Chapter  |  2017

Systematic Review and Meta-analysis: Important Tools in Understanding Drug Development for Stroke

Sarah K McCann, Emily S Sena, Gillian L Currie, Malcolm R Macleod, David W Howells

Book Chapter  |  2017

Conventional protein kinase C beta-mediated phosphorylation inhibits collapsin response-mediated protein 2 proteolysis and alleviates ischemic injury in cultured cortical neurons and ischemic stroke-induced mice

Xuan Yang, Xinxin Zhang, Yun Li, Song Han, David W Howells, Shujuan Li, Junfa Li

Journal article  |  2016  |  Journal of Neurochemistry

Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis

Ralf Watzlawick, Julian Rind, Emily S Sena, Benedikt Brommer, Tian Zhang, Marcel A Kopp, Ulrich Dirnagl, Malcolm R Macleod, David W Howells, Jan M Schwab

Journal article  |  2016  |  PLOS Biology

Extending the Time for Thombolysis in Emergency Neurological Deficits (EXTEND) - Penumbral Patterns Among Patients 4.5-9 Hrs and Wake - Up Stroke

Henry Ma, Bruce C Campbell, Mark W Parsons, Christopher Levi, Atte Meretoja, Leonid Churilov, David Howells, Leeane Carey, Gagan Sharma, Soren Christenen, Bernard Yan, Peter Michell, Nawaf Yassi, Alan Connelly, Hsu Y Chung, Stephen M Davis, Geoffrey A Donnan

Conference Proceedings  |  2016  |  STROKE

A complementary role for tetraspanin superfamily member CD151 and ADP purinergic P2Y(12) receptor in platelets

Mohammed Makkawi, Fatemeh Moheimani, Raed Alserihi, David Howells, Mark Wright, Leonie Ashman, Denise E Jackson

Journal article  |  2015  |  Thrombosis and Haemostasis

A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation

Pamela WM Kleikers, Carlijn Hooijmans, Eva Goeb, Friederike Langhauser, Sarah SJ Rewell, Kim Radermacher, Merel Ritskes-Hoitinga, David W Howells, Christoph Kleinschnitz, Harald HHW Schmidt

Journal article  |  2015  |  Scientific Reports

STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol

Leeanne M Carey, Sheila Crewther, Olivier Salvado, Thomas Linden, Alan Connelly, William Wilson, David W Howells, Leonid Churilov, Henry Ma, Tamara Tse, Stephen Rose, Susan Palmer, Pierrick Bougeat, Bruce CV Campbell, Soren Christensen, S Lance Macaulay, Jenny Favaloro, Victoria O' Collins, Simon McBride, Susan Bates, et al.

Journal article  |  2015  |  International journal of stroke

Fish oil supplementation associated with decreased cellular degeneration and increased cellular proliferation 6 weeks after middle cerebral artery occlusion in the rat

Michaela C Pascoe, David W Howells, David P Crewther, Leeanne M Carey, Sheila G Crewther

Journal article  |  2015  |  NEUROPSYCHIATRIC DISEASE AND TREATMENT

Efficacy of Antidepressants in Animal Models of Ischemic Stroke A Systematic Review and Meta-Analysis

Sarah K McCann, Cadi Irvine, Gillian E Mead, Emily S Sena, Gillian L Currie, Kieren E Egan, Malcolm R Macleod, David W Howells

Journal article  |  2014  |  Stroke

Exercise Reduces Infarct Volume and Facilitates Neurobehavioral Recovery: Results From a Systematic Review and Meta-analysis of Exercise in Experimental Models of Focal Ischemia

Kieren J Egan, Heidi Janssen, Emily S Sena, Lesa Longley, Sally Speare, David W Howells, Neil J Spratt, Malcolm R Macleod, Gillian E Mead, Julie Bernhardt

Journal article  |  2014  |  Neurorehabilitation and Neural Repair

Hypothermia protects human neurons

Ana Antonic, Mirella Dottori, Jessie Leung, Kate Sidon, Peter E Batchelor, William Wilson, Malcolm R Macleod, David W Howells

Journal article  |  2014  |  International Journal of Stroke

Recruitment to trials of late thrombolysis: Lessons from the EXTEND study

Marie Dagonnier, David W Howells, Geoffrey A Donnan, Helen M Dewey

Journal article  |  2014  |  JOURNAL OF CLINICAL NEUROSCIENCE

Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically

Emily S Sena, Gillian L Currie, Sarah K McCann, Malcolm R Macleod, David W Howells

Journal article  |  2014  |  Journal of Cerebral Blood Flow & Metabolism

Detection of activated platelets in a mouse model of carotid artery thrombosis with F-18-labeled single-chain antibodies

Katie Ardipradja, Shinn Dee Yeoh, Karen Alt, Graeme O'Keefe, Angela Rigopoulos, David W Howells, Andrew M Scott, Karlheinz Peter, Uwe Ackerman, Christoph E Hagemeyer

Journal article  |  2014  |  Nuclear Medicine and Biology

Meta-analysis of data from animal studies: A practical guide

HM Vesterinen, ES Sena, KJ Egan, TC Hirst, L Churolov, GL Currie, A Antonic, DW Howells, MR Macleod

Journal article  |  2014  |  Journal of Neuroscience Methods

How to increase value and reduce waste when research priorities are set

Iain Chalmers, Michael B Bracken, Ben Djulbegovic, Silvio Garattini, Jonathan Grant, A Metin Guelmezoglu, David W Howells, John PA Ioannidis, Sandy Oliver

Journal article  |  2014  |  The Lancet

Effect and Reporting Bias of RhoA/ROCK-Blockade Intervention on Locomotor Recovery After Spinal Cord Injury A Systematic Review and Meta-analysis

Ralf Watzlawick, Emily S Sena, Ulrich Dirnagl, Benedikt Brommer, Marcel A Kopp, Malcolm R Macleod, David W Howells, Jan M Schwab

Journal article  |  2014  |  JAMA Neurology

Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment

Michaela C Pascoe, David W Howells, David P Crewther, Nicki Constantinou, Leeanne M Carey, Sarah S Rewell, Giovanni M Turchini, Gunveen Kaur, Sheila G Crewther

Journal article  |  2014  |  FRONTIERS IN NEUROLOGY

Bringing rigour to translational medicine

David W Howells, Emily S Sena, Malcolm R Macleod

Journal article  |  2014  |  Nature Reviews Neurology

Stem Cell Transplantation in Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis of Animal Studies

Ana Antonic, Emily S Sena, Jennifer S Lees, Taryn E Wills, Peta Skeers, Peter E Batchelor, Malcolm R Macleod, David W Howells

Journal article  |  2013  |  PLoS Biology

Corticospinal tract sprouting in the injured rat spinal cord stimulated by Schwann cell preconditioning of the motor cortex

Taryn E Wills, Peter E Batchelor, Nicole F Kerr, Kate Sidon, Melissa Katz, Candace Loy, David W Howells

Journal article  |  2013  |  Neurological Research

Meta-Analysis of Pre-Clinical Studies of Early Decompression in Acute Spinal Cord Injury: A Battle of Time and Pressure

Peter E Batchelor, Taryn E Wills, Peta Skeers, Camila R Battistuzzo, Malcolm R Macleod, David W Howells, Emily S Sena

Journal article  |  2013  |  PLoS One

Systematic Review and Meta-Analysis of Therapeutic Hypothermia in Animal Models of Spinal Cord Injury

Peter E Batchelor, Peta Skeers, Ana Antonic, Taryn E Wills, David W Howells, Malcolm R Macleod, Emily S Sena

Journal article  |  2013  |  PLoS One

Hypertension and experimental stroke therapies

Victoria E O'Collins, Geoffrey A Donnan, Malcolm R Macleod, David W Howells

Journal article  |  2013  |  Journal of Cerebral Blood Flow and Metabolism

Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

Konstantinos K Tsilidis, Orestis A Panagiotou, Emily S Sena, Eleni Aretouli, Evangelos Evangelou, David W Howells, Rustam Al-Shahi Salman, Malcolm R Macleod, John PA Ioannidis

Journal article  |  2013  |  PLoS Biology

A Concerted Appeal for International Cooperation in Preclinical Stroke Research

Ulrich Dirnagl, Antoine Hakim, Malcolm Macleod, Marc Fisher, David Howells, Stuart M Alan, Gary Steinberg, Anna Planas, Johannes Boltze, Sean Savitz, Costantino Iadecola, Stephen Meairs

Journal article  |  2013  |  Stroke

Evidence-based Translational Medicine

David W Howells, Malcolm R Macleod

Journal article  |  2013  |  Stroke

The benefit of hypothermia in experimental ischemic stroke is not affected by pethidine

Emily S Sena, Amy L Jeffreys, Susan F Cox, Stephen A Sastra, Leonid Churilov, Sarah Rewell, Peter E Batchelor, H Bart van der Worp, Malcolm R Macleod, David W Howells

Journal article  |  2013  |  INTERNATIONAL JOURNAL OF STROKE

Animal Models of Stroke Versus Clinical Stroke: Comparison of Infarct Size, Cause, Location, Study Design, and Efficacy of Experimental Therapies

Victoria E O'Collins, Geoffrey A Donnan, Malcolm R Macleod, David W Howells

Book Chapter  |  2013

A novel population of alpha-smooth muscle actin-positive cells activated in a rat model of stroke: an analysis of the spatio-temporal distribution in response to ischemia

Varun Sharma, Tina W Ling, Sarah S Rewell, David L Hare, David W Howells, Angela Kourakis, Peter J Wookey

Journal article  |  2012  |  Journal of Cerebral Blood Flow and Metabolism

A call for transparent reporting to optimize the predictive value of preclinical research

Story C Landis, Susan G Amara, Khusru Asadullah, Chris P Austin, Robi Blumenstein, Eileen W Bradley, Ronald G Crystal, Robert B Darnell, Robert J Ferrante, Howard Fillit, Robert Finkelstein, Marc Fisher, Howard E Gendelman, Robert M Golub, John L Goudreau, Robert A Gross, Amelie K Gubitz, Sharon E Hesterlee, David W Howells, John Huguenard, et al.

Journal article  |  2012  |  Nature

Stem cell-based therapy for experimental stroke: A systematic review and meta-analysis

Jennifer S Lees, Emily S Sena, Kieren J Egan, Ana Antonic, Simon A Koblar, David W Howells, Malcolm R Macleod

Journal article  |  2012  |  International Journal of Stroke

Human In Vitro Models of Ischaemic Stroke: a Test Bed for Translation

Ana Antonic, Emily S Sena, Geoffrey A Donnan, David W Howells

Journal article  |  2012  |  TRANSLATIONAL STROKE RESEARCH

Improving the efficiency of the development of drugs for stroke

David W Howells, Emily S Sena, Victoria O'Collins, Malcolm R Macleod

Journal article  |  2012  |  International Journal of Stroke

The influence of stroke risk factors and comorbidities on assessment of stroke therapies in humans and animals

Sandeep Ankolekar, Sarah Rewell, David W Howells, Philip MW Bath

Journal article  |  2012  |  International Journal of Stroke

Evaluation of combination therapy in animal models of cerebral ischemia

Victoria E O'Collins, Malcolm R Macleod, Geoffrey A Donnan, David W Howells

Journal article  |  2012  |  Journal of Cerebral Blood Flow and Metabolism

A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND)

Henry Ma, Mark W Parsons, Soren Christensen, Bruce CV Campbell, Leonid Churilov, Alan Connelly, Bernard Yan, Chris Bladin, Phan Than, Alan P Barber, Stephen Read, Graeme J Hankey, Romesh Markus, Tissa Wijeratne, R Grimley, N Mahant, Tim Kleinig, John Sturm, A Lee, D Blacker, et al.

Journal article  |  2012  |  International Journal of Stroke

How to make better use of thrombolytic therapy in acute ischemic stroke

Geoffrey A Donnan, Stephen M Davis, Mark W Parsons, Henry Ma, Helen M Dewey, David W Howells

Journal article  |  2011  |  Nature Reviews Neurology

Changes in the solubility and phosphorylation of alpha-synuclein over the course of Parkinson's disease

Jinxia Zhou, Melissa Broe, Yue Huang, John P Anderson, Wei-Ping Gai, Elizabeth A Milward, Michelle Porritt, David Howells, Andrew J Hughes, Xiaomin Wang, Glenda M Halliday

Journal article  |  2011  |  Acta Neuropathologica

Intracanal Pressure in Compressive Spinal Cord Injury: Reduction with Hypothermia

Peter E Batchelor, Nicole F Kerr, Amy M Gatt, Susan F Cox, Ali Ghasem-Zadeh, Taryn E Wills, Tara K Sidon, David W Howells

Journal article  |  2011  |  Journal of Neurotrauma

Preclinical drug evaluation for combination therapy in acute stroke using systematic review, meta-analysis, and subsequent experimental testing

Victoria E O'Collins, Malcolm R Macleod, Susan F Cox, Leena Van Raay, Elena Aleksoska, Geoffrey A Donnan, David W Howells

Journal article  |  2011  |  Journal of Cerebral Blood Flow and Metabolism

'Salvaged' stroke ischaemic penumbra shows significant injury: studies with the hypoxia tracer FMISO

Neil J Spratt, Geoffrey A Donnan, Damian D McLeod, David W Howells

Journal article  |  2011  |  Journal of Cerebral Blood Flow and Metabolism

History of animal models of stroke

Victoria E O'Collins, Geoffrey A Donnan, David W Howells

Journal article  |  2011  |  International Journal of Stroke

Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis

Emily S Sena, Catherine L Briscoe, David W Howells, Geoffrey A Donnan, Peter AG Sandercock, Malcolm R Macleod

Journal article  |  2010  |  Journal of Cerebral Blood Flow and Metabolism

An Enriched Environment Improves Sensorimotor Function Post-Ischemic Stroke

Heidi Janssen, Julie Bernhardt, Janice M Collier, Emily S Sena, Patrick McElduff, John Attia, Michael Pollack, David W Howells, Michael Nilsson, Mike B Calford, Neil J Spratt

Journal article  |  2010  |  Neurorehabilitation and Neural Repair

Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia

David W Howells, Michelle J Porritt, Sarah SJ Rewell, Victoria O'Collins, Emily S Sena, H Bart van der Worp, Richard J Traystman, Malcolm R Macleod

Journal article  |  2010  |  Journal of Cerebral Blood Flow and Metabolism

Hypothermia Prior to Decompression: Buying Time for Treatment of Acute Spinal Cord Injury

Peter E Batchelor, Nicole F Kerr, Amy M Gatt, Elena Aleksoska, Susan F Cox, Ali Ghasem-Zadeh, Taryn E Wills, David W Howells

Journal article  |  2010  |  Journal of Neurotrauma

ACE inhibition reduces infarction in normotensive but not hypertensive rats: correlation with cortical ACE activity

Michelle J Porritt, Michelle Chen, Sarah SJ Rewell, Rachael G Dean, Louise M Burrell, David W Howells

Journal article  |  2010  |  Journal of Cerebral Blood Flow and Metabolism

A systematic review and meta-analysis of erythropoietin in experimental stroke

Mikael Jerndal, Kalle Forsberg, Emily S Sena, Malcolm R Macleod, Victoria E O'Collins, Thomas Linden, Michael Nilsson, David W Howells

Journal article  |  2010  |  Journal of Cerebral Blood Flow and Metabolism

Inducing stroke in aged, hypertensive, diabetic rats

Sarah SJ Rewell, John A Fernandez, Susan F Cox, Neil J Spratt, Lisa Hogan, Elena Aleksoska, Leena van Raay, Gabriel T Liberatore, Peter E Batchelor, David W Howells

Journal article  |  2010  |  Journal of Cerebral Blood Flow and Metabolism

Where Will the Next Generation of Stroke Treatments Come From?

DW Howells, GA Donnan

Journal article  |  2010  |  PLoS Medicine

Can Animal Models of Disease Reliably Inform Human Studies?

H Bart van der Worp, David W Howells, Emily S Sena, Michelle J Porritt, Sarah Rewell, Victoria O'Collins, Malcolm R Macleod

Journal article  |  2010  |  PLOS MEDICINE

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

Emily S Sena, H Bart van der Worp, Philip MW Bath, David W Howells, Malcolm R Macleod

Journal article  |  2010  |  PLoS Medicine

A secretory phospholipase A(2)-mediated neuroprotection and anti-apoptosis

Arunmozhiarasi Armugam, Charmian DN Cher, KaiYing Lim, Dawn CI Koh, David W Howells, Kandiah Jeyaseelan

Journal article  |  2009  |  BMC Neuroscience

Characterisation of the timing of binding of the hypoxia tracer FMISO after stroke

Neil J Spratt, Geoffrey A Donnan, David W Howells

Journal article  |  2009  |  Brain Research

Scope of Preclinical Testing Versus Quality Control Within Experiments

Victoria E O'Collins, Geoffrey A Donnan, Malcolm R Macleod, David W Howells

Journal article  |  2009  |  Stroke

Reprint: Good laboratory practice: preventing introduction of bias at the bench (vol 29, pg 221, 2009)

Malcolm R Macleod, Marc Fisher, Victoria O'Collins, Emily S Sena, Ulrich Dirnagl, Philip MW Bath, Alastair Buchan, H Bart van der Worp, Richard J Traystman, Kazuo Minematsu, Geoffrey A Donnan, David W Howells

Journal article  |  2009  |  JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

Marc Fisher, Giora Feuerstein, David W Howells, Patricia D Hurn, Thomas A Kent, Sean I Savitz, Eng H Lo

Journal article  |  2009  |  Stroke

A Systematic Review Of Erythropoietin In Experimental Stroke

Kalle O Forsberg, Mikael J Jerndal, Emily S Sena, Victoria E O'Collins, Malcolm R Macleod, Thomas Linden, Michael Nilsson, David W Howells

Conference Proceedings  |  2009  |  STROKE

Good Laboratory Practice Preventing Introduction of Bias at the Bench

Malcolm R Macleod, Marc Fisher, Victoria O'Collins, Emily S Sena, Ulrich Dirnagl, Philip MW Bath, Alistair Buchan, H Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A Donnan, David W Howells

Journal article  |  2009  |  Stroke

Good laboratory practice: preventing introduction of bias at the bench (Reprinted)

Malcolm R Macleod, Marc Fisher, Victoria O'Collins, Emily S Sena, Ulrich Dirnagl, Philip MW Bath, Alistair Buchan, H Bart van der Worp, Richard J Traystman, Kazuo Minematsu, Geoffrey A Donnan, David W Howells

Journal article  |  2009  |  International Journal of Stroke

Reprint: Good laboratory practice: preventing introduction of bias at the bench

Malcolm R Macleod, Marc Fisher, Victoria O'Collins, Emily S Sena, Ulrich Dirnagl, Philip MW Bath, Alistair Buchan, H Bart van der Worp, Richard J Traystman, Kazuo Minematsu, Geoffrey A Donnan, David W Howells

Journal article  |  2009  |  Journal of Cerebral Blood Flow and Metabolism

Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality

Malcolm R Macleod, H Bart van der Worp, Emily S Sena, David W Howells, Ulrich Dirnagl, Geoffrey A Donnan

Journal article  |  2008  |  Stroke

Comparison of Inflammation in the Brain and Spinal Cord following Mechanical Injury

Peter E Batchelor, Simon Tan, Taryn E Wills, Michelle J Porritt, David W Howells

Journal article  |  2008  |  Journal of Neurotrauma

Stimulation of axonal sprouting by trophic factors immobilized within the wound core

Peter Egerton Batchelor, Taryn Elizabeth Wills, Ajith Pedru Hewa, Michelle Julie Porritt, David William Howells

Journal article  |  2008  |  Brain Research

Isolating cells from non-sperm cellular mixtures using the PALM microlaser micro dissection system.

Belinda Anoruo, Roland van Oorschot, John Mitchell, David Howells

Journal article  |  2007  |  Forensic Science International

Use of the Positioning Ablation Laser MicroBeam (PALM) microlaser system to isolate specific cellular components from somatic cell..

Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis

H Bart van der Worp, Emily S Sena, Geoffrey A Donnan, David W Howells, Malcolm R Macleod

Journal article  |  2007  |  Brain

How can we improve the pre-clinical development of drugs for stroke?

Emily Sena, H Bart van der Worp, David Howells, Malcolm Macleod

Journal article  |  2007  |  Trends in Neurosciences

Imaging the Penumbra: Positron Emission Tomography Fluoromisonidazole

N SPRATT, D HOWELLS, G DONNAN

Book Chapter  |  2007

Striatal dopaminergic neurons are lost with Parkinson's disease progression

Michelle J Porritt, Ann E Kingsbury, Andrew J Hughes, David W Howells

Journal article  |  2006  |  Movement Disorders

F-18 labelledN,N-bis-haloethylamino-phenylsulfoxides — a new class of compounds for the imaging of hypoxic tissue

Cheryl L Falzon, Uwe Ackermann, Neil Spratt, Henri J Tochon-Danguy, Jonathon White, David Howells, Andrew M Scott

Journal article  |  2006  |  Journal of Labelled Compounds & Radiopharmaceuticals

Modification of the method of thread manufacture improves stroke induction rate and reduces mortality after thread-occlusion of the middle cerebral artery in young or aged rats

Neil J Spratt, John Fernandez, Michelle Chen, Sarah Rewell, Susan Cox, Leena van Raay, Lisa Hogan, David W Howells

Journal article  |  2006  |  Journal of Neuroscience Methods

Modification of the method of thread manufacture improves stroke induction rate and reduces mortality after thread-occlusion of the middle cerebral artery in young or aged rats

Neil J Spratt, John Fernandez, Michelle Chen, Sarah Rewell, Susan Cox, Leena van Raay, Lisa Hogan, David W Howells

Journal article  |  2006  |  Journal of Neuroscience

Characterization of Fluoromisonidazole Binding in Stroke

Neil J Spratt, Uwe Ackerman, Henri J Tochon-Danguy, Geoffrey A Donnan, David W Howells

Journal article  |  2006  |  Stroke

Laser microdissection and pressure catapulting with PALM® to assist typing of target DNA in dirt samples

BL Lambie-Anoruo, DV Prince, I Koukoulas, DW Howells, RJ Mitchell, RAH van Oorschot

Journal article  |  2006  |  International Congress Series

1,026 Experimental treatments in acute stroke

Victoria E O'Collins, Malcolm R Macleod, Geoffrey A Donnan, Laura L Horky, Bart H van der Worp, David W Howells

Journal article  |  2006  |  Annals of Neurology

Inflammation following stroke

M Nilupul Perera, Henry K Ma, Shuji Arakawa, David W Howells, Romesh Markus, Christopher C Rowe, Geoffrey A Donnan

Journal article  |  2006  |  Journal of Clinical Neuroscience

Dopaminergic innervation of the human striatum in Parkinson's disease

M Porritt, D Stanic, D Finkelstein, P Batchelor, S Lockhart, A Hughes, R Kalnins, D Howells

Journal article  |  2005  |  Movement Disorders

Vampire bat salivary plasminogen activator (desmoteplase) inhibits tissue-type plasminogen activator-induced potentiation of excitotoxic injury

C Reddrop, RX Moldrich, PM Beart, M Farso, GT Liberatore, DW Howells, KU Petersen, WD Schleuning, RL Medcalf

Journal article  |  2005  |  Stroke

Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke

MR Macleod, T O'Collins, LL Horky, DW Howells, GA Donnan

Journal article  |  2005  |  Journal of Cerebral Blood Flow and Metabolism

Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons

MJ Porritt, PE Batchelor, DW Howells

Journal article  |  2005  |  Experimental Neurology

Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke

MR Macleod, T O'Collins, LL Horky, DW Howells, GA Donnan

Journal article  |  2005  |  Journal of Pineal Research

Ischaemic tolerance and mitochondrial uncoupling - Can we learn from the cell?

NJ Spratt, DW Howells

Journal article  |  2005  |  Cerebrovascular Diseases

The resistance to ischemia of white and gray matter after stroke

ALE Falcao, DC Reutens, R Markus, M Koga, SJ Read, H Tochon-Danguy, J Sachinidis, DW Howells, GA Donnan

Journal article  |  2004  |  Annals of Neurology

Pooling of animal experimental data reveals influence of study design and publication bias

MR Macleod, T O'Collins, DW Howells, GA Donnan

Journal article  |  2004  |  Stroke

Imaging the Ischemic Penumbra with 18 F-Fluoromisonidazole in a Rat Model of Ischemic Stroke

Kazuko Saita, Michelle Chen, Neil J Spratt, Michelle J Porritt, Gabriel T Liberatore, Stephen J Read, Christopher R Levi, Geoffrey A Donnan, Uwe Ackermann, Henri J Tochon-Danguy, John I Sachinidis, David W Howells

Journal article  |  2004  |  Stroke

CNS regeneration: clinical possibility or basic science fantasy?

PE Batchelor, DW Howells

Journal article  |  2003  |  Journal of Clinical Neuroscience

Stem cell therapies: a tale of caution

E Byrne, DW Howells

Journal article  |  2003  |  Medical Journal of Australia

Stem cells: Do they replace or stimulate?

D Howells

Journal article  |  2003  |  Stroke

Can the time window for administration of thrombolytics in stroke be increased?

GA Donnan, DW Howells, R Markus, D Toni, SM Davis

Journal article  |  2003  |  CNS Drugs

Macrophages and Microglia Produce Local Trophic Gradients That Stimulate Axonal Sprouting Toward but Not beyond the Wound Edge

P Batchelor

Journal article  |  2002  |  Molecular and Cellular Neurosciences

Periwound dopaminergic sprouting is dependent on numbers of wound macrophages

PE Batchelor, MJ Porritt, SK Nilsson, I Bertoncello, GA Donnan, DW Howells

Journal article  |  2002  |  European Journal of Neuroscience

Salvaging the ischaemic penumbra: More than just reperfusion?

TG Phan, PM Wright, R Markus, DW Howells, SM Davis, GA Donnan

Journal article  |  2002  |  Clinical and Experimental Pharmacology and Physiology

New dopaminergic neurons in Parkinson's disease striatum

DW HOWELLS

Journal article  |  2001  |  Focus on Parkinson's disease