David Howells

A Systematic Review and Meta-Analysis on the Therapeutic Efficacy of Heparin and Low Molecular Weight Heparins in Animal Studies of Traumatic Brain Injury.

Mimieveshiofuo Aiyede, Xin Yi Lim, Ash AM Russell, Rahul P Patel, Nuri Gueven, David W Howells, Nicole Bye

Journal article  |  2023  |  J Neurotrauma

The identification of effective pharmacotherapies for traumatic brain injury (TBI) remains a major challenge. Treatment with hepar..

Vascular perfusion differs in two distinct PDGFR beta-positive zones within the ischemic core of male mice 2 weeks following photothrombotic stroke

Gary PP Morris, Emma KK Gowing, Jo-Maree Courtney, Hannah EE Coombe, Natalie EE King, Sarah SJ Rewell, David WW Howells, Andrew NN Clarkson, Brad AA Sutherland

Journal article  |  2022  |  JOURNAL OF NEUROSCIENCE RESEARCH

Stroke therapy has largely focused on preventing damage and encouraging repair outside the ischemic core, as the core is considere..

Automated Quantification of Multiple Cell Types in Fluorescently Labeled Whole Mouse Brain Sections Using QuPath.

Jo-Maree Courtney, Gary P Morris, Elise M Cleary, David W Howells, Brad A Sutherland

Journal article  |  2022  |  Bio Protoc

The quantification of labeled cells in tissue sections is crucial to the advancement of biological knowledge. Traditionally, this ..

Pharmacological PDGFRβ inhibitors imatinib and sunitinib cause human brain pericyte death in vitro.

Natalie E King, Jo-Maree Courtney, Lachlan S Brown, Catherine G Foster, Jake M Cashion, Emily Attrill, Dino Premilovac, David W Howells, Brad A Sutherland

Journal article  |  2022  |  Toxicol Appl Pharmacol

Capillary pericytes have numerous functions important for tissue maintenance. Changes in pericyte function are implicated in disea..

Fibrin clot characteristics and anticoagulant response in a SARS-CoV-2-infected endothelial model.

Conor McCafferty, Leo Lee, Tengyi Cai, Slavica Praporski, Julian Stolper, Vasiliki Karlaftis, Chantal Attard, David Myint, Leeanne M Carey, David W Howells, Geoffrey A Donnan, Stephen Davis, Henry Ma, Sheila Crewther, Vinh A Nguyen, Suelyn Van Den Helm, Natasha Letunica, Ella Swaney, David Elliott, Kanta Subbarao, et al.

Journal article  |  2022  |  EJHaem

Coronavirus disease 2019 (COVID-19) patients have increased thrombosis risk. With increasing age, there is an increase in COVID-19..

Optimisation of Iron Oxide Nanoparticles for Agglomeration and Blockage in Aqueous Flow Systems

LM Landowski, KL Livesey, O Bibari, AM Russell, MR Taylor, CC Ho, DW Howells, RO Fuller

Journal article  |  2022  |  Australian Journal of Chemistry

The translation of nanoparticles to useful applications is often hindered by the reliability of synthetic methodologies to reprodu..

What has preclinical systematic review ever done for us?

Ash Allanna Mark Russell, Brad A Sutherland, Lila M Landowski, Malcolm Macleod, David W Howells

Journal article  |  2022  |  BMJ Open Sci

Systematic review and meta-analysis are a gift to the modern researcher, delivering a crystallised understanding of the existing r..

An Automated Approach to Improve the Quantification of Pericytes and Microglia in Whole Mouse Brain Sections.

Jo-Maree Courtney, Gary P Morris, Elise M Cleary, David W Howells, Brad A Sutherland

Journal article  |  2021  |  eNeuro

Whole slide scanning technology has enabled the generation of high-resolution images from complete tissue sections. However, commo..

Circadian Biology and Stroke

Eng H Lo, Gregory W Albers, Martin Dichgans, Geoffrey Donnan, Elga Esposito, Russell Foster, David W Howells, Yi-Ge Huang, Xunming Ji, Elizabeth B Klerman, Sarah Lee, Wenlu Li, David S Liebeskind, Ignacio Lizasoain, Emiri T Mandeville, Maria A Moro, MingMing Ning, David Ray, Sava Sakadzic, Jeffrey L Saver, et al.

Journal article  |  2021  |  STROKE

Circadian biology modulates almost all aspects of mammalian physiology, disease, and response to therapies. Emerging data suggest ..

Differences in fatigue-like behavior in the lipopolysaccharide and poly I:C inflammatory animal models.

Catherine G Foster, Lila M Landowski, Brad A Sutherland, David W Howells

Journal article  |  2021  |  Physiol Behav

Central fatigue is a condition associated with impairment of the central nervous system often leading to the manifestation of a ra..