www.wehi.edu.au/people/nicos-nicola Research interest
Our work in cytokine biology has spanned over 35 years and has included: The discovery and purification of cytokines (granulocyte colony-stimulating factor, G-CSF and leukemia inhibitory factor, LIF). The cloning of cytokine receptors (for GM-CSF and interleukin 13). The discovery and elucidation of the roles of the intracellular signalling molecules, the suppressors of cytokine signaling (SOCS) proteins.Our current work involves determining the molecular mechanism of action of SOCS proteins at the structural level and their roles in myeloproliferative neoplasms. We are also defining the roles of a new family of cytokine signalling inhibitors, the MARCH proteins.
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Nicos Nicola's highlights
FEATURED Journal article
Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation
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Scholarly Works
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Honours, Awards and Fellowships
1996
FAA - Fellow of the Australian Academy of Science
Credentials
Positions
Honorary
Medical Biology (W.E.H.I.)
Education
Bachelor of Science
Institution not known
Doctor of Philosophy
Institution not known