Nicos Nicola

Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9

Jarrod J Sandow, Andrew I Webb, Dina Stockwell, Nadia J Kershaw, Cyrus Tan, Satoshi Ishido, Warren S Alexander, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola

Journal article  |  2021  |  Proteomics

MARCH proteins are membrane-associated Ring-CH E3 ubiquitin ligases that dampen immune responses by downregulating cell surface ex..

RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

Kirsteen M Tullett, Peck Szee Tan, Hae-Young Park, Ralf B Schittenhelm, Nicole Michael, Rong Li, Antonia N Policheni, Emily Gruber, Cheng Huang, Alex J Fulcher, Jillian C Danne, Peter E Czabotar, Linda M Wakim, Justine D Mintern, Georg Ramm, Kristen J Radford, Irina Caminschi, Meredith O'Keeffe, Jose A Villadangos, Mark D Wright, et al.

Journal article  |  2020  |  eLife

The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction o..

Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1

Nicholas PD Liau, Artem Laktyushin, Rhiannon Morris, Jarrod J Sandow, Nicos A Nicola, Nadia J Kershaw, Jeffrey J Babon

Journal article  |  2019  |  Cancers

Janus kinases (JAKs) are found constitutively associated with cytokine receptors and are present in an inactive state prior to cyt..

Membrane-associated RING-CH (MARCH) proteins down-regulate cell surface expression of the interleukin-6 receptor alpha chain (IL6R alpha)

Jeffrey J Babon, Dina Stockwell, Ladina DiRago, Jian-Guo Zhang, Artem Laktyushin, Jose Villadangos, Alan Ching, Satoshi Ishido, Douglas J Hilton, Warren S Alexander, Nicos A Nicola

Journal article  |  2019  |  Biochemical Journal

Interleukin 6 (IL6) is a cytokine that regulates a number of important immune and inflammatory pathways. We used the ability of IL..

RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses

Thomas J Hayman, Alan C Hsu, Tatiana B Kolesnik, Laura F Dagley, Joschka Willemsen, Michelle D Tate, Paul J Baker, Nadia J Kershaw, Lukasz Kedzierski, Andrew Webb, Peter A Wark, Katherine Kedzierska, Seth L Masters, Gabrielle T Belz, Marco Binder, Philip M Hansbro, Nicos A Nicola, Sandra E Nicholson

Journal article  |  2019  |  Immunology and Cell Biology

The innate immune system is our first line of defense against viral pathogens. Host cell pattern recognition receptors sense viral..

The molecular basis of JAK/STAT inhibition by SOCS1

Nicholas PD Liau, Artem Laktyushin, Isabelle S Lucet, James M Murphy, Shenggen Yao, Eden Whitlock, Kimberley Callaghan, Nicos A Nicola, Nadia J Kershaw, Jeffrey J Babon

Journal article  |  2018  |  Nature Communications

The SOCS family of proteins are negative-feedback inhibitors of signalling induced by cytokines that act via the JAK/STAT pathway...

Identification of a second binding site on the TRIM25 B30.2 domain

Akshay A D'Cruz, Nadia J Kershaw, Thomas J Hayman, Edmond M Linossi, Jessica J Chiang, May K Wang, Laura F Dagley, Tatiana B Kolesnik, Jian-Guo Zhang, Seth L Masters, Michael DW Griffin, Michaela U Gack, James M Murphy, Nicos A Nicola, Jeffrey J Babon, Sandra E Nicholson

Journal article  |  2018  |  Biochemical Journal

The retinoic acid-inducible gene-I (RIG-I) receptor recognizes short 5'-di- and triphosphate base-paired viral RNA and is a critic..

Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a

Jacob T Jackson, Benjamin J Shields, Wei Shi, Ladina Di Rago, Donald Metcalf, Nicos A Nicola, Matthew P McCormack

Journal article  |  2017  |  Stem Cells

The hematopoietically expressed homeobox transcription factor (Hhex) is important for the maturation of definitive hematopoietic p..

Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor

Nicholas M Gough, Jill Gough, Donald Metcalf, Anne Kelso, Dianne Grail, Nicos A Nicola, Antony W Burgess, Ashley R Dunn

Journal article  |  2017  |  The Journal of Immunology

cDNA clones specifying the murine granulocyte-macrophage colony stimulating factor have been isolated. This haematopoietic growth ..

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

Lukasz Kedzierski, Michelle D Tate, Alan C Hsu, Tatiana B Kolesnik, Edmond M Linossi, Laura Dagley, Zhaoguang Dong, Sarah Freeman, Giuseppe Infusini, Malcolm R Starkey, Nicola L Bird, Simon M Chatfield, Jeffrey J Babon, Nicholas Huntington, Gabrielle Belz, Andrew webb, Peter AB Wark, Nicos A Nicola, Jianqing Xu, Katherine Kedzierska, et al.

Journal article  |  2017  |  eLife

Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering fr..