profile icon
Professor

Andrew Lew

Honorary
Medical Biology (W.E.H.I.)
animals
mice
science & technology
life sciences & biomedicine
immunology
mice, inbred c57bl
humans
dendritic cells
mice, transgenic
Andrew Lew's Profile Picture
Professor

Andrew Lew

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Activation and death of immune cells during type 1 diabetes and islet transplantation
Andrew Lew's Profile Picture
Professor

Andrew Lew

 

Our lab targets local immune responses for islet transplantation in type 1 diabetes and targets dendritic cells to improve or dampen immune responses. As such, molecular, cellular and whole-body immunology skills are used.

Major findings of our lab include:

  • the key autoantigen in autoimmune diabetes was proinsulin/insulin
  • peptide mimicry was identified between autoantigens in human type 1 diabetes
  • NOD and B6 IgG2c is an isotype, not an allotype of the BALB/c IgG2a
  • role of cross-presentation in DNA vaccination
  • targeting lymphoid organs enhances immune responses
  • devising of an in vivo model of quantifying cross-presentation using selective suicide of cross-presenting dendritic cells by cytochrome c.
  • whereas CD40L on CD4 T cells is important for licensing dendritic cells, we showed that conversely the ability to induce CD40L on dendritic cells explains why only some viruses can elicit killer T cells in the absence of CD4 T cell help.
  • success in the prolongation of islet graft survival by genetic modification of islets.

    Recent verification that this immunosuppression is localised to the graft thereby circumventing systemic effects (susceptibility to infections) and bypassing the toxicity of transplant drugs.


lew@wehi.edu.au

www.wehi.edu.au/people/andrew-lew

Scholarly Works

Displaying the 248 most recent scholarly works by Andrew Lew.

Credentials

Positions


Honorary

Medical Biology (W.E.H.I.)

It Access

Medical Biology (W.E.H.I.)

Honorary

Medical Biology (W.E.H.I.)

Education


Master of Veterinary Science

University of London

Doctor of Philosophy

University of London