Andrew Lew

Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development.

Lingli Zhou, Tao Liu, Bing Huang, Man Luo, Zhanghua Chen, Zhiyao Zhao, Jun Wang, Daniel Leung, Xingtian Yang, Koon Wing Chan, Yukun Liu, Liya Xiong, Peiyu Chen, Hongli Wang, Liping Ye, Hanquan Liang, Seth L Masters, Andrew M Lew, Sitang Gong, Fan Bai, et al.

Journal article  |  2021  |  Journal of Allergy and Clinical Immunology

BACKGROUND: Very-early-onset inflammatory bowel disease (VEOIBD) is a chronic inflammatory disease of the gastrointestinal tract o..

Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia.

Jun Wang, Yanhui Xu, Zhanghua Chen, Jiankun Liang, Zefeng Lin, Huiying Liang, Yiping Xu, Qi Wu, Xuanjie Guo, Junli Nie, Bingtai Lu, Bing Huang, Huifang Xian, Xiaohui Wang, Qiang Wu, Jixiao Zeng, Chengwei Chai, Meixue Zhang, Yuzhen Lin, Li Zhang, et al.

Journal article  |  2020  |  Cell

Biliary atresia (BA) is a severe cholangiopathy that leads to liver failure in infants, but its pathogenesis remains to be fully c..

Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19

Xiaoyan Liu, Zhe Li, Shuai Liu, Jing Sun, Zhanghua Chen, Min Jiang, Qingling Zhang, Yinghua Wei, Xin Wang, Yi-You Huang, Yinyi Shi, Yanhui Xu, Huifang Xian, Fan Bai, Changxing Ou, Bei Xiong, Andrew M Lew, Jun Cui, Rongli Fang, Hui Huang, et al.

Journal article  |  2020  |  Acta Pharmaceutica Sinica B

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause acute respiratory distress syndrome, hypercoagula..

Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity

Junyun Lai, Sherly Mardiana, Imran G House, Kevin Sek, Melissa A Henderson, Lauren Giuffrida, Amanda XY Chen, Kirsten L Todd, Emma Petley, Jack D Chan, Emma M Carrington, Andrew M Lew, Benjamin J Solomon, Joseph A Trapani, Katherine Kedzierska, Maximilien Evrard, Stephin J Vervoort, Jason Waithman, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  Nature Immunology

Adoptive cell therapies using genetically engineered T cell receptor or chimeric antigen receptor T cells are emerging forms of im..

Microbiota-derived butyrate promotes metabolism and memory potential of effector CD8( )T cells

Annabell Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Dedreia Tull, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, Axel Kallies, Malcolm McConville, Stephen J Turner, Thomas Gebhardt, Sammy Bedoui

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

Compound Heterozygous Mutations of IL12RB1 in a Patient with Selective Defects in Th17 Differentiation

Ming Liu, Bingtai Lu, Ping Zeng, Bing Huang, Yanhui Xu, Hanquan Liang, Diyuan Yang, Sida Yang, Hai-bin Luo, Andrew M Lew, Seth L Masters, Lanlan Geng, Huasong Zeng, Yuxia Zhang

Journal article  |  2020  |  Journal of Clinical Immunology

Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity

Yifan Zhan, Isabella Kong, Michael Chopin, Christophe Macri, Jian-Guo Zhang, Jiaying Xie, Stephen L Nutt, Meredith O'Keeffe, Edwin D Hawkins, Eric F Morand, Andrew M Lew

Journal article  |  2020  |  Immunology and Cell Biology

The NZB/W F1 (F1) mice develop severe disease that is similar to human systemic lupus erythematosus. By contrast, each parent stra..

IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia

Bingtai Lu, Ming Liu, Jun Wang, Huifeng Fan, Diyuan Yang, Li Zhang, Xiaoqiong Gu, Junli Nie, Zhenjun Chen, Alexandra J Corbett, Michael J Zhan, Shengbo Zhang, Vanessa L Bryant, Andrew M Lew, James McCluskey, Hai-bin Luo, Jun Cui, Yuxia Zhang, Yifan Zhan, Gen Lu

Journal article  |  2020  |  Mucosal Immunology

Community-acquired pneumonia (CAP) contributes substantially to morbidity and mortality in children under the age of 5 years. In e..

CCR2 enhances CD25 expression by FoxP3( ) regulatory T cells and regulates their abundance independently of chemotaxis and CCR2( ) myeloid cells

Yifan Zhan, Nancy Wang, Ajithkumar Vasanthakumar, Yuxia Zhang, Michael Chopin, Stephen L Nutt, Axel Kallies, Andrew M Lew

Journal article  |  2020  |  Cellular & Molecular Immunology

A wide array of chemokine receptors, including CCR2, are known to control Treg migration. Here, we report that CCR2 regulates Treg..

The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game

Yifan Zhan, Andrew M Lew, Michael Chopin

Journal article  |  2019  |  Frontiers in Immunology