Our lab targets local immune responses for islet transplantation in type 1 diabetes and targets dendritic cells to improve or dampen immune responses. As such, molecular, cellular and whole-body immunology skills are used.
Major findings of our lab include:
- the key autoantigen in autoimmune diabetes was proinsulin/insulin
- peptide mimicry was identified between autoantigens in human type 1 diabetes
- NOD and B6 IgG2c is an isotype, not an allotype of the BALB/c IgG2a
- role of cross-presentation in DNA vaccination
- targeting lymphoid organs enhances immune responses
- devising of an in vivo model of quantifying cross-presentation using selective suicide of cross-presenting dendritic cells by cytochrome c.
- whereas CD40L on CD4 T cells is important for licensing dendritic cells, we showed that conversely the ability to induce CD40L on dendritic cells explains why only some viruses can elicit killer T cells in the absence of CD4 T cell help.
- success in the prolongation of islet graft survival by genetic modification of islets.
Recent verification that this immunosuppression is localised to the graft thereby circumventing systemic effects (susceptibility to infections) and bypassing the toxicity of transplant drugs.
lew@wehi.edu.au
www.wehi.edu.au/people/andrew-lew
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Helping Themselves: Optimal Virus-Specific CD4 T Cell Responses Require Help via CD4 T Cell Licensing of Dendritic Cells
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Credentials
Positions
Honorary
Medical Biology (W.E.H.I.)
It Access
Medical Biology (W.E.H.I.)
Honorary
Medical Biology (W.E.H.I.)
Education
Master of Veterinary Science
University of London
Doctor of Philosophy
University of London