Graham Baldwin

Experimental rat models for contrast-induced nephropathy; A comprehensive review

M Perera, J Ischia, D Bolton, A Shulkes, GS Baldwin, O Patel

Journal article  |  2020  |  Journal of Nephropathology

Contrast-induced nephropathy (CIN) is an iatrogenic disease caused by the parenteral administration of iodinated contrast media (C..

Zinc preconditioning protects against renal ischaemia-reperfusion injury through manipulation of key metabolic pathways

D O'kane, G Baldwin, D Bolton, O Patel, J Ischia

Conference Proceedings  |  2020  |  BJU INTERNATIONAL

Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1

Kai Wang, Yifan Zhan, Huynh Nhi, Chelsea Dumesny, Xiao Wang, Khashayer Asadi, David Herrmann, Paul Timpson, Yang Yang, Katrina Walsh, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2020  |  Cancer Letters

Immunotherapies have not yielded significant clinical benefits for pancreatic ductal adenocarcinoma (PDA) because of the existence..

Preconditioning against renal ischaemia reperfusion injury: the failure to translate to the clinic

Dermot O'Kane, Graham S Baldwin, Damien M Bolton, Joseph J Ischia, Oneel Patel

Journal article  |  2019  |  Journal of Nephrology

Antitumor effects of all-trans retinoic acid and its synergism with gemcitabine are associated with downregulation of p21-activated kinases in pancreatic cancer

Kai Wang, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2019  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Zinc protects the kidney against ischaemia-reperfusion injury: investigating the mechanisms of protection in wild-type and genetic-knockout murine strains

D O'Kane, J Du Plessis, A Shulkes, G Baldwin, D Bolton, J Ischia, O Patel

Conference Proceedings  |  2019  |  BJU INTERNATIONAL

PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagents in patient-derived pancreatic cancer cell lines

Kai Wang, Huynh Nhi, Xiao Wang, Marina Pajic, Ashleigh Parkin, Jennifer Man, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2019  |  American Journal of Translational Research

Corrigendum to "Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?"

Kapil Sethi, Kenny Rao, Arthur Shulkes, Graham Baldwin, Damien Bolton, Oneel Patel, Joseph Ischia

Journal article  |  2019  |  International Journal of Cell Biology

[This corrects the article DOI: 10.1155/2018/9852791.].

Zinc preconditioning protects against renal ischaemia reperfusion injury in a preclinical sheep large animal model

Dermot O'Kane, Luke Gibson, Clive N May, Justin du Plessis, Arthur Shulkes, Graham S Baldwin, Damien Bolton, Joseph Ischia, Oneel Patel

Journal article  |  2018  |  BioMetals

p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation

Kai Wang, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2018  |  World Journal of Gastroenterology

Zinc ion dyshomeostasis increases resistance of prostate cancer cells to oxidative stress via upregulation of HIF1α.

David Wetherell, Graham S Baldwin, Arthur Shulkes, Damien Bolton, Joseph Ischia, Oneel Patel

Journal article  |  2018  |  Oncotarget

Zinc ions (Zn2+) are known to influence cell survival and proliferation. However the homeostatic regulation of Zn2+ and their role..

Oral trivalent bismuth ions decrease, and trivalent indium or ruthenium ions increase, intestinal tumor burden in Apc(Delta 14/ ) mice

Marie Laval, Chelsea Dumesny, Mal Eutick, Graham S Baldwin, Kathryn M Marshall

Journal article  |  2018  |  Metallomics

Inhibition of p21 activated kinase enhances tumour immune response and sensitizes pancreatic cancer to gemcitabine

Kai Wang, Huynh Nhi, Xiao Wang, Graham Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2018  |  International Journal of Oncology

Complexes of gastrin with In3 , Ru3 or Ga3 ions are not recognised by the cholecystokinin 2 receptor

Marie Laval, Kathryn M Marshall, John Sachinidis, Andrew Scott, Mal Eutick, Graham S Baldwin

Journal article  |  2017  |  JBIC Journal of Biological Inorganic Chemistry

Protective effect of zinc preconditioning against renal ischemia reperfusion injury is dose dependent

Kenny Rao, Kapil Sethi, Joseph Ischia, Luke Gibson, Laurence Galea, Lin Xiao, Mildred Yim, Mike Chang, Nathan Papa, Damien Bolton, Arthur Shulkes, Graham S Baldwin, Oneel Patel

Journal article  |  2017  |  PLOS ONE

Progastrin: a potential predictive marker of liver metastasis in colorectal cancer

David A Westwood, Oneel Patel, Christopher Christophi, Arthur Shulkes, Graham S Baldwin

Journal article  |  2017  |  International Journal of Colorectal Disease

Depletion of p21-activated kinase 1 up-regulates the immune system of APC(Delta 14/ ) mice and inhibits intestinal tumorigenesis

Nhi Huynh, Kai Wang, Mildred Yim, Chelsea J Dumesny, Mauro S Sandrin, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2017  |  BMC Cancer

Inhibition of Group 1 p21-Activated Kinases Suppresses Pancreatic Stellate Cell Activation and Increases Survival of Mice with Pancreatic Cancer

Dannel Yeo, Phoebe Phillips, Graham S Baldwin, Hong He, Mehrdad Nikfarjam

Journal article  |  2017  |  International Journal of Cancer

Zinc Ions Mediate Gastrin Expression, Proliferation, and Migration Downstream of the Cholecystokinin-2 Receptor

Mike Chang, Lin Xiao, Arthur Shulkes, Graham S Baldwin, Oneel Patel

Journal article  |  2016  |  Endocrinology

FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine

Dannel Yeo, Hong He, Oneel Patel, Andrew M Lowy, Graham S Baldwin, Mehrdad Nikfarjam

Journal article  |  2016  |  BMC Cancer

Glaucarubinone Combined with Gemcitabine Improves Pancreatic Cancer Survival in an Immunocompetent Orthotopic Murine Model

Dannel Yeo, Huynh Nhi, John A Beutler, Graham S Baldwin, Hong He, Mehrdad Nikfarjam

Journal article  |  2016  |  Journal of Investigative Surgery

Up-regulation of stem cell markers by P21-activated kinase 1 contributes to 5-fluorouracil resistance of colorectal cancer

Nhi Huynh, Arthur Shulkes, Graham Baldwin, Hong He

Journal article  |  2016  |  Cancer Biology & Therapy

Tyrosine modification increases the affinity of gastrin for ferric ions

Graham S Baldwin, Ioulia Sims

Journal article  |  2015  |  SpringerPlus

Retro-inverso forms of gastrin(5-12) are as biologically active as glycine-extended gastrin in vitro but not in vivo

Kathryn M Marshall, Marie Laval, Ioulia Sims, Arthur Shulkes, Graham S Baldwin

Journal article  |  2015  |  Peptides

High Affinity Binding of Indium and Ruthenium Ions by Gastrins

Graham S Baldwin, Graham N George, M Jake Pushie

Journal article  |  2015  |  PLOS ONE

Identification of binding sites for C-terminal pro-gastrin-releasing peptide (GRP)-derived peptides in renal cell carcinoma: a potential target for future therapy

Joseph Ischia, Oneel Patel, Kapil Sethi, Marianne S Nordlund, Damien Bolton, Arthur Shulkes, Graham S Baldwin

Journal article  |  2015  |  BJU International

The Role of p21-Activated Kinases in Pancreatic Cancer

Dannel Yeo, Hong He, Graham S Baldwin, Mehrdad Nikfarjam

Journal article  |  2015  |  Pancreas

HIF1 alpha Expression under Normoxia in Prostate Cancer-Which Pathways to Target?

Weranja KB Ranasinghe, Graham S Baldwin, Damien Bolton, Arthur Shulkes, Joseph Ischia, Oneel Patel

Journal article  |  2015  |  Journal of Urology

Increased gastrin gene expression provides a physiological advantage to mice under hypoxic conditions

Marie Laval, Graham S Baldwin, Arthur Shulkes, Kathryn M Marshall

Journal article  |  2015  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1 alpha and beta-catenin via a p-21 activated kinase 1-dependent pathway

Huynh Nhi, John A Beutler, Arthur Shulkes, Graham S Baldwin, Hong He

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo

Kathryn M Marshall, Marie Laval, Ortis Estacio, Damien F Hudson, Paul Kalitsis, Arthur Shulkes, Graham S Baldwina, Oneel Patel

Journal article  |  2015  |  Metallomics

Gastrin mediates resistance to hypoxia-induced cell death in xenografts of the human colorectal cancer cell line LoVo

David A Westwood, Oneel Patel, Graham S Baldwin

Journal article  |  2014  |  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Normoxic regulation of HIF-1α in prostate cancer.

Weranja KB Ranasinghe, Graham S Baldwin, Arthur Shulkes, Damien Bolton, Oneel Patel

Journal article  |  2014  |  Nature Reviews Urology

Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells

Nhi Huynh, Kevin H Liu, Mildred Yim, Arthur Shulkes, Graham S Baldwin, Hong He

Journal article  |  2014  |  Physiological Reports

Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases

Dannel Yeo, Huynh Nhi, John A Beutler, Christopher Christophi, Arthur Shulkes, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2014  |  Cancer Letters

The effects of nonspecific HIF1 alpha inhibitors on development of castrate resistance and metastases in prostate cancer

Weranja KB Ranasinghe, Shomik Sengupta, Scott Williams, Mike Chang, Arthur Shulkes, Damien M Bolton, Graham Baldwin, Oneel Patel

Journal article  |  2014  |  Cancer Medicine

Activation of Src family tyrosine kinases by ferric ions

Graham S Baldwin, Daisy Sio-Seng Lio, Audrey Ferrand, Bruno Catimel, B Philip Shehan, Raymond S Norton, Heung-Chin Cheng

Journal article  |  2014  |  Biochimica et Biophysica Acta-Protein Structure and Molecular Enzymology

Circulating gastrin concentrations in patients at increased risk of developing colorectal carcinoma

Adrienne C Paterson, Finlay A Macrae, Cathy Pizzey, Graham S Baldwin, Arthur Shulkes

Journal article  |  2014  |  Journal of Gastroenterology and Hepatology

Expression and function of gastrin-releasing peptide (GRP) in normal and cancerous urological tissues

Joseph Ischia, Oneel Patel, Damien Bolton, Arthur Shulkes, Graham S Baldwin

Journal article  |  2014  |  BJU International

Zinc ions upregulate the hormone gastrin via an E-box motif in the proximal gastrin promoter

Lin Xiao, Suzana Kovac, Mike Chang, Arthur Shulkes, Graham S Baldwin, Oneel Patel

Journal article  |  2014  |  Journal of Molecular Endocrinology

Comparison of Two Syngeneic Orthotopic Murine Models of Pancreatic Adenocarcinoma

Mehrdad Nikfarjam, Dannel Yeo, Hong He, Graham Baldwin, Theodora Fifis, Patricia Costa, Bryan Tan, Eunice Yang, Shu Wen Wen, Christopher Christophi

Journal article  |  2013  |  Journal of Investigative Surgery

P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1 alpha

Kevin H Liu, Huynh Nhi, Oneel Patel, Arthur Shulkes, Graham Baldwin, Hong He

Journal article  |  2013  |  Cancer Letters

Gastrin

A Shulkes, GS Baldwin

Book Chapter  |  2013

The C-terminal flanking peptide of progastrin induces gastric cell apoptosis and stimulates colonic cell division in vivo

Kathryn M Marshall, Oneel Patel, Gianni Bramante, Marie Laval, Mildred Yim, Graham S Baldwin, Arthur Shulkes

Journal article  |  2013  |  Peptides

Non-specific HIF1 alpha inhibitors in men receiving androgen deprivation therapy for prostate cancer

W Ranasinghe, S Sengupta, S Williams, M Chang, A Shulkes, D Bolton, G Baldwin, O Patel

Conference Proceedings  |  2013  |  BJU International

p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways

Huynh Nhi, Mildred Yim, Jonathan Chernoff, Arthur Shulkes, Graham S Baldwin, Hong He

Journal article  |  2013  |  American Journal of Physiology - Gastrointestinal and Liver Physiology

The Role of Hypoxia-Inducible Factor 1 alpha in Determining the Properties of Castrate-Resistant Prostate Cancers

Weranja KB Ranasinghe, Lin Xiao, Suzana Kovac, Mike Chang, Carine Michiels, Damien Bolton, Arthur Shulkes, Graham S Baldwin, Oneel Patel

Journal article  |  2013  |  PLoS One

p21-activated kinases and gastrointestinal cancer

Hong He, Graham S Baldwin

Journal article  |  2013  |  BBA - General Subjects

A RETROSPECTIVE ANALYSIS OF 100 MEN WITH PROSTATE CANCER: DOES HIF1 DETERMINE CASTRATE RESISTANCE AND ITS CHARACTERISTICS?

W Ranasinghe, L Xiao, S Kovac, M Chang, A Shulkes, D Bolton, G Baldwin, O Patel

Journal article  |  2012  |  Asia Pacific Journal of Clinical Oncology

Induction of Gastrin Expression in Gastrointestinal Cells by Hypoxia or Cobalt Is Independent of Hypoxia-Inducible Factor (HIF)

Lin Xiao, Suzana Kovac, Mike Chang, Arthur Shulkes, Graham S Baldwin, Oneel Patel

Journal article  |  2012  |  Endocrinology

P-21 activated kinase 1 knockdown inhibits beta-catenin signalling and blocks colorectal cancer growth

Hong He, Huynh Nhi, Kevin H Liu, Cathy Malcontenti-Wilson, Jin Zhu, Christopher Christophi, Arthur Shulkes, Graham S Baldwin

Journal article  |  2012  |  Cancer Letters

Pro-GRP-Derived Peptides Are Expressed in Colorectal Cancer Cells and Tumors and Are Biologically Active in Vivo

Oneel Patel, Daniel Clyde, Mike Chang, Marianne S Nordlund, Rohan Steel, Bruce E Kemp, D Mark Pritchard, Arthur Shulkes, Graham S Baldwin

Journal article  |  2012  |  Endocrinology

Bismuth ions inhibit the biological activity of non-amidated gastrins in vivo

Suzana Kovac, Su-Wen Loh, Shamilah Lachal, Arthur Shulkes, Graham S Baldwin

Journal article  |  2012  |  Biochemical Pharmacology

Pro-GRP-derived peptides are expressed in colorectal cancer cells and tumors and are biologically active in vivo

O Patel, undefined Clyde, AA Shulkes, G Baldwin, undefined Chang, undefined Nordlund, undefined Steel, undefined Kemp, undefined Pritchard

Journal article  |  2012  |  Endocrinology

Gastrin-Deficient Mice Have Disturbed Hematopoiesis in Response to Iron Deficiency

Suzana Kovac, Gregory J Anderson, Warren S Alexander, Arthur Shulkes, Graham S Baldwin

Journal article  |  2011  |  Endocrinology

Gastrins, iron homeostasis and colorectal cancer

Suzana Kovac, Gregory J Anderson, Graham S Baldwin

Journal article  |  2011  |  Biochimica et Biophysica Acta - General Subjects

Ferric ions inhibit proteolytic processing of progastrin

Gianni Bramante, Oneel Patel, Arthur Shulkes, Graham S Baldwin

Journal article  |  2011  |  Biochemical and Biophysical Research Communications

The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway

Oneel Patel, Kathryn M Marshall, Gianni Bramante, Graham S Baldwin, Arthur Shulkes

Journal article  |  2010  |  Regulatory Peptides

Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor

Suzana Kovac, Lin Xiao, Arthur Shulkes, Oneel Patel, Graham S Baldwin

Journal article  |  2010  |  FEBS Letters

P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways

Nhi Huynh, Kevin H Liu, Graham S Baldwin, Hong He

Journal article  |  2010  |  Biochimica et Biophysica Acta - Molecular Cell Research

Evolution of gastrointestinal hormones: the cholecystokinin/gastrin family

Graham S Baldwin, Oneel Patel, Arthur Shulkes

Journal article  |  2010  |  Current Opinion in Endocrinology, Diabetes and Obesity

The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway

O Patel, K Marshall, G BRAMANTE, G Baldwin, AA Shulkes

Journal article  |  2010  |  Regulatory Peptides

Definition of the residues required for the interaction between glycine-extended gastrin and transferrin in vitro

Suzana Kovac, Audrey Ferrand, Jean-Pierre Esteve, Anne B Mason, Graham S Baldwin

Journal article  |  2009  |  FEBS Journal

Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth

Audrey Ferrand, Mauro S Sandrin, Arthur Shulkes, Graham S Baldwin

Journal article  |  2009  |  Biochimica et Biophysica Acta - Molecular Cell Research

Peptide processing and biology in human disease

Suzana Kovac, Arthur Shulkes, Graham S Baldwin

Journal article  |  2009  |  Current Opinion in Endocrinology, Diabetes and Obesity

Phosphorylation of cyclin-dependent kinase 2 peptides enhances metal binding

Graham S Baldwin

Journal article  |  2009  |  Biochemical and Biophysical Research Communications

Gastrin-releasing peptide: Different forms, different functions

Joseph Ischia, Oneel Patel, Arthur Shulkes, Graham S Baldwin

Journal article  |  2009  |  BioFactors: vitamins - autoregulatory substances - trace elements - growth factors

Gastrins, iron and colorectal cancer

Graham S Baldwin

Journal article  |  2009  |  Metallomics: integrated biometal science

Tyrosine modification enhances metal-ion binding

Graham S Baldwin, Michael F Bailey, B Philip Shehan, Loulia Sims, Raymond S Norton

Journal article  |  2008  |  Biochemical Journal

Interrelationships between circulating gastrin and iron status in mice and humans

Suzana Kovac, Kelly Smith, Gregory J Anderson, John R Burgess, Arthur Shulkes, Graham S Baldwin

Journal article  |  2008  |  American Journal of Physiology - Gastrointestinal and Liver Physiology

PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins

Hong He, Arthur Shulkes, Graham S Baldwin

Journal article  |  2008  |  Biochimica et Biophysica Acta - Molecular Cell Research

Preparation and properties of recombinant rat and human procholecystokinin(57-95)

Susann Friedrich, Yulia Sims, Graham S Baldwin

Journal article  |  2008  |  The Protein Journal

Gastrin is not required for liver regeneration

Amra Dizdarevic, Nadia Harun, Cathy Malcontenti-Wilson, Arthur Shulkes, Christopher Christophi, Graham S Baldwin

Journal article  |  2008  |  ANZ Journal of Surgery

Rho GTPases and p21-activated kinase in the regulation of proliferation and apoptosis by gastrins

Hong He, Graham S Baldwin

Journal article  |  2008  |  International Journal of Biochemistry and Cell Biology

Preparation and properties of recombinant rat and human procholecystokinin(57-95)

S Friedrich, IV Sims, G Baldwin

Journal article  |  2008  |  Cellular Signaling

Gastrin-releasing peptide

O PATEL, A SHULKES, G BALDWIN

Book Chapter  |  2008

Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by Gastrins

Hong He, Mildred Yim, Kevin H Liu, Stephen C Cody, Arthur Shulkes, Graham S Baldwin

Journal article  |  2008  |  Cellular Signaling

beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors

Julie Pannequin, Nathalie Delaunay, Michael Buchert, Fanny Surrel, Jean-Franqois Bourgaux, Joanne Ryan, Stephanie Boireau, Jessica Coelho, Andre Pelegrin, Pomila Singh, Arthur Shulkes, Mildred Yim, Graham S Baldwin, Christine Pignodel, Gerard Lambeau, Philippe Jay, Dominique Joubert, Frederic Hollande

Journal article  |  2007  |  Gastroenterology

Phylogenetic analysis of the sequences of gastrin-releasing peptide and its receptors: Biological implications

Graham S Baldwin, Oneel Patel, Arthur Shulkes

Journal article  |  2007  |  Regulatory Peptides

Recombinant C-terminal fragments of the gastrin-releasing peptide precursor are bioactive

Oneel Patel, Chelsea Dumesny, Arthur Shulkes, Graham S Baldwin

Journal article  |  2007  |  Cancer Letters

C-terminal fragments of the gastrin-releasing peptide precursor stimulate cell proliferation via a novel receptor

Oneel Patel, Chelsea Dumesny, Arthur Shulkes, Graham S Baldwin

Journal article  |  2007  |  Endocrinology

CCK receptors and cancer

Graham S Baldwin, Arthur Shulkes

Journal article  |  2007  |  Current Topics in Medicinal Chemistry

beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors

J Pannequin, N Delaunay, M Buchert, F Surrel, JF Bourgaux, J Ryan, S Boireau, J Coelho, A Pelegrin, P Singh, AA Shulkes, ME Yim, G Baldwin, C Pignodel, G Lambeau, P Jay, D Joubert, F Hollande

Journal article  |  2007  |  Gastroenterology

Circulating gastrin is increased in hemochromatosis

Kelly A Smith, Suzana Kovac, Gregory J Anderson, Arthur Shulkes, Graham S Baldwin

Journal article  |  2006  |  FEBS Letters

Production, secretion, and biological activity of the C-terminal flanking peptide of human progastrin

Kelly A Smith, Oneel Patel, Shamilah Lachal, Ian Jennings, Bruce Kemp, John Burgess, Graham S Baldwin, Arthur Shulkes

Journal article  |  2006  |  Gastroenterology

Gastrin-releasing peptide and cancer

Oneel Patel, Arthur Shulkes, Graham S Baldwin

Journal article  |  2006  |  BBA - Reviews on Cancer

Mitogenic effects of both amidated and glycine-extended gastrin-releasing peptide in defunctioned and azoxymethane-treated rat colon in vivo

N Houli, SW Loh, AS Giraud, GS Baldwin, A Shulkes

Journal article  |  2006  |  Regulatory Peptides

Regulation of Gastric Acid Secretion

Arthur Shulkes, Graham S Baldwin, Andrew S Giraud

Book Chapter  |  2006

Synthesis, expression and biological activity of the prohormone for gastrin releasing peptide (ProGRP)

C Dumesny, O Patel, S Lachal, AS Giraud, GS Baldwin, A Shulkes

Journal article  |  2006  |  Endocrinology

Glycine-extended gastrin stimulates cell proliferation and migration through a Rho- and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway

H He, J Pannequin, JP Tantiongco, A Shulkes, GS Baldwin

Journal article  |  2005  |  American Journal of Physiology - Gastrointestinal and Liver Physiology

Signaling the junctions in gut epithelium.

Frédéric Hollande, Arthur Shulkes, Graham S Baldwin

Journal article  |  2005  |  Signal Transduction Knowledge Environment

This Perspective summarizes recent developments in our understanding of the signaling pathways involved in the regulation of epith..

Stimulation of proliferation and migration of a colorectal cancer cell line by amidated and glycine-extended gastrin-releasing peptide via the same receptor

O Patel, C Dumesny, AS Giraud, GS Baldwin, A Shulkes

Journal article  |  2004  |  Biochemical Pharmacology

Identity and regulation of stored and secreted progastrin-derived peptides in sheep

AC Paterson, SM Lockhart, J Baker, G Neumann, GS Baldwin, A Shulkes

Journal article  |  2004  |  Endocrinology

Biological activity and ferric ion binding of fragments of glycine-extended gastrin

H He, BP Shehan, KJ Barnham, RS Norton, A Shulkes, GS Baldwin

Journal article  |  2004  |  Biochemistry

Developmental expression and biological activity of gastrin-releasing peptide and its receptors in the kidney

C Dumesny, JC Whitley, GS Baldwin, AS Giraud, A Shulkes

Journal article  |  2004  |  American Journal of Physiology: Renal Physiology

PPAR alpha agonists stimulate progastrin production in human colorectal carcinoma cells

S Lachal, J Ford, A Shulkes, GS Baldwin

Journal article  |  2004  |  Regulatory Peptides

Gastrins, cholecystokinins and gastrointestinal cancer

A Aly, A Shulkes, GS Baldwin

Journal article  |  2004  |  BBA - Reviews on Cancer

Divergent roles for ferric ions in the biological activity of amidated and non-amidated gastrins

J Pannequin, JP Tantiongco, S Kovac, A Shulkes, GS Baldwin

Journal article  |  2004  |  Journal of Endocrinology

A novel effect of bismuth ions - Selective inhibition of the biological activity of glycine-extended gastrin

J Pannequin, S Kovac, JP Tantiongco, RS Norton, A Shulkes, KJ Barnham, GS Baldwin

Journal article  |  2004  |  Journal of Biological Chemistry

Gastrins, gastrin receptors, and colon cancer

GS BALDWIN

Book Chapter  |  2004

Method of treatment

GS BALDWIN, KJ BARNHAM, J PANNEQUIN, J TANTIONGCO, AA SHULKES, RS NORTON, S KOVAC, H HE, BP SHEHAN

Patent  |  2004

Properties of the complex between recombinant human progastrin and ferric ions

GS Baldwin

Journal article  |  2004  |  The Protein Journal

Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells

F Hollande, DJ Lee, A Choquet, S Roche, GS Baldwin

Journal article  |  2003  |  Journal of Cell Science

Ferric ions are essential for the biological activity of the hormone glycine-extended gastrin

J Pannequin, KJ Barnham, F Hollande, A Shulkes, RS Norton, GS Baldwin

Journal article  |  2002  |  Journal of Biological Chemistry

Preparation of biologically active recombinant human progastrin(1-80)

K McQueen, S Kovac, PK Ho, K Rorison, J Pannequin, G Neumann, A Shulkes, GS Baldwin

Journal article  |  2002  |  Journal of Protein Chemistry

Metabolism of recombinant progastrin in sheep

AC Paterson, GS Baldwin, A Shulkes

Journal article  |  2002  |  American Journal of Physiology - Endocrinology and Metabolism

Involvement of phosphatidylinositol 3-kinase and mitogen-activated protein kinases in glycine-extended gastrin-induced dissociation and migration of gastric epithelial cells

F Hollande, A Choquet, EM Blanc, DJ Lee, JP Bali, GS Baldwin

Journal article  |  2001  |  Journal of Biological Chemistry

Identification of a 70-kDa gastrin-binding protein on DLD-1 human colorectal carcinoma cells

CH Yang, J Ford, Y Karelina, A Shulkes, SD Xiao, GS Baldwin

Journal article  |  2001  |  International Journal of Biochemistry and Cell Biology

Short term infusion of glycine-extended gastrin(17) stimulates both proliferation and formation of aberrant crypt foci in rat colonic mucosa

A Aly, A Shulkes, GS Baldwin

Journal article  |  2001  |  International Journal of Cancer

Selective, high-affinity binding of ferric ions by glycine-extended gastrin(17)

GS Baldwin, CC Curtain, WH Sawyer

Journal article  |  2001  |  Biochemistry

Mutation of lysine residues of the 78-kDa gastrin-binding protein reduces gastrin binding

KA Rorison, DJ Lee, GS Baldwin

Journal article  |  2001  |  Journal of Protein Chemistry

HGF regulates tight junctions in new nontumorigenic gastric epithelial cell line

F Hollande, EM Blanc, JP Bali, RH Whitehead, A Pelegrin, GS Baldwin, A Choquet

Journal article  |  2001  |  American Journal of Physiology - Gastrointestinal and Liver Physiology

Inhibition of the preferential binding of actin to the N-terminal hydratase domain of the 78-kDa gastrin-binding protein by nonsteroidal anti-inflammatory drugs and gastrin receptor antagonists

GS Baldwin

Journal article  |  2001  |  Biochemical Pharmacology

Biologically active recombinant human Progastrin(6-80) contains a tightly bound calcium ion

GS Baldwin, F Hollande, ZY Yang, Y Karelina, A Paterson, R Strang, D Fourmy, G Neumann, A Shulkes

Journal article  |  2001  |  Journal of Biological Chemistry

Regulatory peptides: what do they regulate?

A Shulkes, G Baldwin, A Giraud

Journal article  |  2001  |  Trends in Endocrinology and Metabolism

Binding sites for progastrin-derived peptides in colonic crypts

Y Karelina, GS Baldwin

Journal article  |  2001  |  Journal of Gastroenterology and Hepatology

Biology and pathology of non-amidated gastrins

A Shulkes, G Baldwin

Journal article  |  2001  |  Scandinavian Journal of Clinical and Laboratory Investigation