profile icon
Prof

Graham Baldwin

Honorary
Surgery - Austin Health
science & technology
life sciences & biomedicine
humans
animals
gastrins
mice
biochemistry & molecular biology
glycine-extended gastrin
cell proliferation
Graham Baldwin's Profile Picture
Prof

Graham Baldwin

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Growth factors and gastrointestinal cancer
Graham Baldwin's Profile Picture
Prof

Graham Baldwin

 
Print
Graham's  Short Profile
 

Patents

Displaying the most recent patent by Graham Baldwin.

Patent icon

Method of treatment

GS BALDWIN, KJ BARNHAM, J PANNEQUIN, J TANTIONGCO, AA SHULKES, RS NORTON, S KOVAC, H HE, BP SHEHAN

October 21, 2004

1

Patents

Projects

Displaying the 10 most recent projects by Graham Baldwin.

Project icon

ROLES FOR GASTRIN AND HYPOXIA IN COLORECTAL CANCER DEVELOPMENT

Our objective is to understand how hormones such as gastrin stimulate the development of colorectal cancer. Our preliminary data shows that ..

2014 - 2016
Completed
Project icon

Targetting proGRP as a therapeutic strategy for gastrointestinal cancers

This interdisciplinary project defines what constitutes global competencies for engineers. It focuses on building knowledge and theory about..

2013 - 2014
Completed
Project icon

Targetting the Kinase PAK1 in Colorectal Cancer

This project aims to develop a new therapy for colorectal cancer (CRC). We have already demonstrated that a molecule called PAK1 is the mast..

2013 - 2016
Completed
Project icon

GASTRINS AND COLORECTAL CANCER

My major goal for the past 20 years has been to understand how hormones such as gastrin stimulate the development of gastrointestinal cancer..

2012 - 2016
Completed
Project icon

Role of gastrin prohormones in the development of gastrointestinal cancers

Gastrin is a stomach hormone which increases acid secretion and the growth of the stomach and bowel. This growth promoting effect may be inv..

2011 - 2013
Completed
Project icon

Role of the Growth Factor ProGRP in the Development of Gastrointestinal Cancers

Our objective is to determine the roles of a growth factor termed bombesin. This peptide, known as GRP in the human, is a growth factor in c..

2010 - 2012
Completed
Project icon

Gastrin, Iron and Colorectal Cancer

Our objective is to understand the biological significance of the interaction between iron and the hormone gastrin. The project's significan..

2009 - 2011
Completed
Project icon

ProGRP as a biomarker for prostate cancer

To develop a bespoke manufacturing platform for cladding and machining of steel/nickel super alloy stacks and to deliver an optimised proces..

2008 - 2010
Completed
Project icon

Physiology and pathology of novel forms of progastrin

Gastrin is a stomach hormone which increases acid secretion and the growth of the stomach and bowel. This growth promoting effect may be inv..

2008 - 2011
Completed
Project icon

Biology of GRP precursors

Colorectal carcinoma (cancer of the large bowel) is the second most common cause of cancer death. Colorectal carcinomas in common with other..

2007 - 2009
Completed

18

Projects

Project Types

18

Research Grant

Scholarly Works

Displaying the 10 most recent scholarly works by Graham Baldwin.

Scholarly works icon

Experimental rat models for contrast-induced nephropathy; A comprehensive review

M Perera, J Ischia, D Bolton, A Shulkes, GS Baldwin, O Patel

Journal article  |  2020  |  Journal of Nephropathology

Contrast-induced nephropathy (CIN) is an iatrogenic disease caused by the parenteral administration of iodinated contrast media (C..

Scholarly works icon

Zinc preconditioning protects against renal ischaemia-reperfusion injury through manipulation of key metabolic pathways

D O'kane, G Baldwin, D Bolton, O Patel, J Ischia

Conference Proceedings  |  2020  |  BJU INTERNATIONAL

Scholarly works icon

Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1

Kai Wang, Yifan Zhan, Huynh Nhi, Chelsea Dumesny, Xiao Wang, Khashayer Asadi, David Herrmann, Paul Timpson, Yang Yang, Katrina Walsh, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2020  |  Cancer Letters

Immunotherapies have not yielded significant clinical benefits for pancreatic ductal adenocarcinoma (PDA) because of the existence..

Scholarly works icon

Preconditioning against renal ischaemia reperfusion injury: the failure to translate to the clinic

Dermot O'Kane, Graham S Baldwin, Damien M Bolton, Joseph J Ischia, Oneel Patel

Journal article  |  2019  |  Journal of Nephrology

Scholarly works icon

Antitumor effects of all-trans retinoic acid and its synergism with gemcitabine are associated with downregulation of p21-activated kinases in pancreatic cancer

Kai Wang, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2019  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Scholarly works icon

Zinc protects the kidney against ischaemia-reperfusion injury: investigating the mechanisms of protection in wild-type and genetic-knockout murine strains

D O'Kane, J Du Plessis, A Shulkes, G Baldwin, D Bolton, J Ischia, O Patel

Conference Proceedings  |  2019  |  BJU INTERNATIONAL

Scholarly works icon

PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagents in patient-derived pancreatic cancer cell lines

Kai Wang, Huynh Nhi, Xiao Wang, Marina Pajic, Ashleigh Parkin, Jennifer Man, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2019  |  American Journal of Translational Research

Scholarly works icon

Corrigendum to "Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?"

Kapil Sethi, Kenny Rao, Arthur Shulkes, Graham Baldwin, Damien Bolton, Oneel Patel, Joseph Ischia

Journal article  |  2019  |  International Journal of Cell Biology

[This corrects the article DOI: 10.1155/2018/9852791.].

Scholarly works icon

Zinc preconditioning protects against renal ischaemia reperfusion injury in a preclinical sheep large animal model

Dermot O'Kane, Luke Gibson, Clive N May, Justin du Plessis, Arthur Shulkes, Graham S Baldwin, Damien Bolton, Joseph Ischia, Oneel Patel

Journal article  |  2018  |  BioMetals

Scholarly works icon

p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation

Kai Wang, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2018  |  World Journal of Gastroenterology

116

Scholarly Works

Keyword Analysis

Clinical Sciences
Clinical (organs, Diseases and Abnormal Conditions)
Clinical Health (organs, Diseases and Abnormal Conditions)
Oncology and Carcinogenesis
Biochemistry and Cell Biology
Immunology
Other Health
Health and Support Services
Analytical Chemistry
Genetics

Honours, Awards and Fellowships

2007

GE Healthcare Biosciences Award

Australian Society of Biochemistry and Molecular Biology
2003

University of Melbourne

2

Awards

Credentials

Positions

Honorary

Surgery - Austin Health

Member

American Gastroenterological Association

Member

National Association of Research Fellows

Member, Research Committee

Gastroenterological Association of Australia

Education

Doctor of Science

University of Melbourne

Doctor of Philosophy

University of Melbourne

Bachelor of Science

University of Melbourne