Anu Sakthianandeswaren

Defining the susceptibility of colorectal cancers to BH3-mimetic compounds

Ming-Jie Luo, Michelle Palmieri, Chris D Riffkin, Anuratha Sakthianandeswaren, Tirta Mario Djajawi, Yumiko Hirokawa, Victoria Shuttleworth, David H Segal, Christine A White, Duong Nhu, Guillaume Lessene, Margaret Lee, Peter Gibbs, David CS Huang, Oliver M Sieber, Jia-nan Gong

Journal article  |  2020  |  Cell Death and Disease

Novel targets are required to improve the outcomes for patients with colorectal cancers. In this regard, the selective inhibitor o..

Tumour infiltrating lymphocyte status is superior to histological grade, DNA mismatch repair and BRAF mutation for prognosis of colorectal adenocarcinomas with mucinous differentiation

David S Williams, Dmitri Mouradov, Marsali R Newman, Elham Amini, David K Nickless, Catherine G Fang, Michelle Palmieri, Anuratha Sakthianandeswaren, Shan Li, Robyn L Ward, Nicholas J Hawkins, Iain Skinner, Ian Jones, Peter Gibbs, Oliver M Sieber

Journal article  |  2020  |  Modern Pathology

Mucinous colorectal adenocarcinoma (CRC) is conventionally defined by extracellular mucin comprising >50% of the tumour area, whil..

Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes

David S Williams, Dmitri Mouradov, Robert N Jorissen, Marsali R Newman, Elham Amini, David K Nickless, Julie A Teague, Catherine G Fang, Michelle Palmieri, Marie J Parsons, Anuratha Sakthianandeswaren, Shan Li, Robyn L Ward, Nicholas J Hawkins, Ian Faragher, Ian T Jones, Peter Gibbs, Oliver M Sieber

Journal article  |  2019  |  Gut

Immunoscore-has it scored for colon cancer precision medicine?

Robert N Jorissen, Anuratha Sakthianandeswaren, Oliver M Sieber

Journal article  |  2018  |  Annals of Translational Medicine

MACROD2 deletions cause impaired PARP1 activity and chromosome instability in colorectal cancer.

Anuratha Sakthianandeswaren, Marie J Parsons, Dmitri Mouradov, Oliver M Sieber

Journal article  |  2018  |  Oncotarget

MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors

Anuratha Sakthianandeswaren, Marie J Parsons, Dmitri Mouradov, Ruth N MacKinnon, Bruno Catimel, Sheng Liu, Michelle Palmieri, Christopher Love, Robert N Jorissen, Shan Li, Lachlan Whitehead, Tracy L Putoczki, Adele Preaudet, Cary Tsui, Cameron J Nowell, Robyn L Ward, Nicholas J Hawkins, Jayesh Desai, Peter Gibbs, Matthias Ernst, et al.

Journal article  |  2018  |  Cancer Discovery

Long noncoding RNA LINP1: scaffolding non-homologous end joining

A Sakthianandeswaren, S Liu, OM Sieber

Journal article  |  2016  |  Cell Death Discovery

Single Nucleotide Polymorphism Array Profiling Identifies Distinct Chromosomal Aberration Patterns Across Colorectal Adenomas and Carcinomas

Peter Zarzour, Lies Boelen, Fabio Luciani, Dominik Beck, Anuratha Sakthianandeswaren, Dmitri Mouradov, Oliver M Sieber, Nicholas J Hawkins, Luke B Hesson, Robyn L Ward, Jason WH Wong

Journal article  |  2015  |  Genes Chromosomes and Cancer

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/beta-catenin signalling thresholds for tumourigenesis

M Christie, RN Jorissen, D Mouradov, A Sakthianandeswaren, S Li, F Day, C Tsui, L Lipton, J Desai, IT Jones, S McLaughlin, RL Ward, NJ Hawkins, AR Ruszkiewicz, J Moore, AW Burgess, D Busam, Q Zhao, RL Strausberg, AJ Simpson, et al.

Journal article  |  2013  |  Oncogene

Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion

Neel Sengupta, Christopher Yau, Anuratha Sakthianandeswaren, Dmitri Mouradov, Peter Gibbs, Nirosha Suraweera, Jean-Baptiste Cazier, Guadalupe Polanco-Echeverry, Anil Ghosh, Mohamed Thaha, Shafi Ahmed, Roger Feakins, David Propper, Sina Dorudi, Oliver Sieber, Andrew Silver, Cecilia Lai

Journal article  |  2013  |  Molecular Cancer