Prof Shaun Brennecke

Prof Brennecke is the University of Melbourne Dunbar Hooper Professor of Obstetrics and Gynaecology at the Royal Women’s Hospital in Melbourne, Victoria, Australia.He is also the Director of the Department of Maternal-Fetal Medicine, a Team Leader within the Maternity Service and Head of the Pregnancy Research Centre at the Hospital. Prof Brennecke’s research interests focus on Maternal-Fetal Medicine, especially preeclampsia, fetal growth restriction, placental function, preterm labour, reproductive tissue stem cells, miscarriage, the endocrinology of human pregnancy and parturition, the assessment of fetal welfare, and factors influencing maternal and perinatal morbidity and mortality.

To date, he has published over 260 research papers on these topics. (See https://www.ncbi.nlm.nih.gov/pubmed/?term=brennecke+s) His h-index is 47 (source: Google Scholar), and his RG score is 46.64 (>97.5%’ile) (source: ResearchGate).

Find out more about Shaun Brennecke's experience

Shaun Brennecke's highlights

FEATURED Journal article

Predicting Preterm Labour: Current Status and Future Prospects

Shaun Brennecke's selected work

Prediction And Prevention Of Spontaneous Preterm Birth: An Individual Participant Data Met..

Research Grant

Increased decidual mRNA expression levels of candidate maternal preeclampsia susceptibilit..

Journal article

Maternal Ophthalmic Artery Doppler Waveform Analysis In The Assessment And Management Of P..

Research Grant

Control of extravillous trophoblast function by the eotaxins CCL11, CCL24 and CCL26

Journal article

Fetal Lactate Measurement In Labour

Research Grant

Contemporary clinical management of the cerebral complications of preeclampsia.

Journal article

Projects

Displaying the 10 most recent projects by Shaun Brennecke.

Prediction And Prevention Of Spontaneous Preterm Birth: An Individual Participant Data Meta-Analysis Comprising Of Prognostic And Therapeutic Data

Spontaneous preterm birth is an important issue in obstetric care. Since potential treatments (pessary, progesterone) are available, accurat..

2018 - 2021

Active

Fetal Lactate Measurement In Labour

Caesarean section rates in Australia are well above the World Health Organization’s recommended level. Many babies appear unhealthy in labou..

2012 - 2015

Completed

Xcelligence Rtca Dp System

2011 - 2011

Completed

What Controls Blood Vessel Changes In A Mother During Pregnancy?

2011 - 2012

Completed

Understanding How Proteoglycans In The Placenta Cause Restriction Of Fetal Growth

Fetal growth restriction (FGR) is a pregnancy complication in which the baby doesn�t grow properly in the womb. Growth restricted babies are..

2011 - 2013

Completed

Stem Cells In A Human Pregnancy Disorder

The placenta is a rich source of stem cells. We have discovered that stem cells from placentae affected by fetal growth restriction (FGR), a..

2008 - 2010

Completed

Identification Of Pre-Eclampsia Susceptibility Genes

2006 - 2011

Completed

Pathogenesis Of Pre-Eclampsia: Effects Of Microparticle-Derived Proteins On Endothelial Cells

Towards Using Placental Mesenchymal Stem Cells

Completed

Understanding The Molecular Mechanism Of Fetal Growth Restriction; A Pregnancy Disorder That Prevents A Healthy Start To Life

10

Projects

Project Types

Research Grant

Research Contracts

Internal Research Grant

Scholarly Works

Displaying the 361 most recent scholarly works by Shaun Brennecke.

Decidual mesenchymal stem/stromal cell-derived extracellular vesicles ameliorate endothelial cell proliferation, inflammation, and oxidative stress in a cell culture model of preeclampsia.

Shixuan Zheng, Aiwu Shi, Sophia Hill, Claire Grant, Maria I Kokkinos, Padma Murthi, Harry M Georgiou, Shaun P Brennecke, Bill Kalionis

Journal article | 2020 | Pregnancy Hypertension

Oxidative stress and endothelial dysfunction contribute substantially to the pathogenesis of preeclampsia (PE). Decidual mesenchym..

NO placental inflammation

Helena C Parkington, Penelope M Sheehan, Harold A Coleman, Shaun P Brennecke

Journal article | 2020 | The Journal of Physiology

Prediction of preterm pre-eclampsia at midpregnancy using a multivariable screening algorithm

Carin Black, Daniel Lorber Rolnik, Ahmed Al-Amin, Stefan C Kane, Caroline Stolarek, Adrienne White, Fabricio Da Silva Costa, Shaun Brennecke

Journal article | 2020 | Australian and New Zealand Journal of Obstetrics and Gynaecology

BACKGROUND: Competing risk models used for midpregnancy prediction of preterm pre-eclampsia have shown detection rates (DR) of 85%..

Early Pregnancy Screening for Women at High-Risk of GDM Results in Reduced Neonatal Morbidity and Similar Maternal Outcomes to Routine Screening

Erin Clarke, Thomas J Cade, Shaun P Brennecke

Journal article | 2020 | Journal of Pregnancy

The Australasian Diabetes in Pregnancy Society recommends screening high-risk women for gestational diabetes mellitus (GDM) before..

Opportunities for improving hypertensive disorders of pregnancy (HDP) management in primary care settings: A review of international published guidelines in the context of pregnancy care in Indonesia

Fitriana Murriya Ekawati, Ova Emilia, Shaun Brennecke, Jane Gunn, Sharon Licqurish, Phyllis Lau

Journal article | 2020 | Pregnancy Hypertension

Almost all of global maternal mortality caused by HDP occurs in low to middle-income countries (LMIC). However, limited guidance i..

Optic nerve sonography and ophthalmic artery Doppler velocimetry in healthy pregnant women: an Australian cohort study

Stefan C Kane, Alicia T Dennis, Fabricio Da Silva Costa, Louise H Kornman, Thomas J Cade, Shaun P Brennecke

Journal article | 2019 | Journal of Clinical Ultrasound

PURPOSE: Maternal ocular sonography offers a window into cerebrovascular and intracranial pressure changes in pregnancy. This stud..

Is there a correlation between maternal serum sFlt-1/PlGF ratios and birthweight centiles?

J Dean, G Jones, T Cade, S Brennecke

Conference Proceedings | 2019 | AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

Midpregnancy testing for soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF): An inter-assay comparison of three automated immunoassay platforms

Carin Black, Ahmed Al-Amin, Daniel Lorber Rolnik, Stefan C Kane, Caroline Stolarek, Adrienne White, Fabricio da Silva Costa, Shaun Brennecke

Journal article | 2019 | Placenta

A Novel Panel of Mid-trimester Biomarkers to Predict Preterm Labour

M Di Quinzio, S Brennecke, P Sheehan, C Grant, N Arbel, S Leow, Z Ng, T Amitay, Y Wei, H Georgiou

Conference Proceedings | 2019 | AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

Does the Maternal Serum sFlt-1/PlGF Ratio Test Distinguish Between Growth Restricted and Non-Growth Restricted Small-for-Gestational-Age Fetuses?

P Rajiv, G Jones, T Cade, S Brennecke

Conference Proceedings | 2019 | AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

Women's experiences of preeclampsia: a prospective survey of preeclamptic women at a single tertiary centre

Natasha Frawley, Christine East, Shaun Brennecke

Journal article | 2019 | Journal of Obstetrics and Gynaecology

Implications of the introduction of new criteria for the diagnosis of gestational diabetes: a health outcome and cost of care analysis

Thomas J Cade, Alexander Polyakov, Shaun P Brennecke

Journal article | 2019 | BMJ Open

Whole-exome sequencing in multiplex preeclampsia families identifies novel candidate susceptibility genes

Phillip E Melton, Matthew P Johnson, Dnyanada Gokhale-Agashe, Alexander J Rea, Amir Ariff, Gemma Cadby, Juan M Peralta, Tegan J Mcnab, Richard JN Allcock, Lawrence J Abraham, John Blangero, Shaun P Brennecke, Eric K Moses

Journal article | 2019 | Journal of Hypertension

Maternal Loeys-Dietz syndrome (transforming growth factor ligand 2) in a twin pregnancy: Case report and discussion

Homira Bashari, Alexandra Brooks, Orla O'Brien, Shaun Brennecke, Dominica Zentner

Journal article | 2019 | SAGE OPEN MEDICAL CASE REPORTS

Midpregnancy prediction of pre-eclampsia using serum biomarkers sFlt-1 and PlGF

Carin Black, Ahmed Al-Amin, Caroline Stolarek, Stefan C Kane, Daniel Lorber Rolnik, Adrienne White, Fabricio da Silva Costa, Shaun Brennecke

Journal article | 2019 | Pregnancy Hypertension

Analysis of the Epigenome in Multiplex Pre-eclampsia Families Identifies SORD, DGKI, and ICA1 as Novel Candidate Risk Genes

Amir Ariff, Phillip E Melton, Shaun P Brennecke, Eric K Moses

Journal article | 2019 | Frontiers in Genetics

Soluble fms-like tyrosine kinase-1 to placental growth factor ratio: ruling out pre-eclampsia for up to 4weeks and value of retesting

H Zeisler, E Llurba, FJ Chantraine, M Vatish, AC Staff, M Sennstrom, M Olovsson, SP Brennecke, H Stepan, D Allegranza, M Schoedl, S Grill, M Hund, S Verlohren

Journal article | 2019 | Ultrasound in Obstetrics & Gynecology

Developing management pathways for hypertensive disorders of pregnancy (HDP) in Indonesian primary care: a study protocol

Fitriana Murriya Ekawati, Sharon Licqurish, Ova Emilia, Jane Gunn, Shaun Brennecke, Phyllis Lau

Journal article | 2019 | Reproductive Health

Background National and international guidelines for the management of hypertensive disorders of pregnancy (HDP) are available in ..

Decreased placental glypican expression is associated with human fetal growth restriction

T Gunatillake, A Chui, E Fitzpatrick, V Ignjatovic, P Monagle, J Whitelock, D Zanten, J Eijsink, A Borg, J Stevenson, SP Brennecke, JJHM Erwich, JM Said, P Murthi

Journal article | 2019 | Placenta

Novel protein biomarker combinations that predict preterm birth

Megan K Di Quinzio, Shaun P Brennecke, Penelope M Sheehan, Nir Arbel, San Min Leow, Zhen Long Ng, Amitay Tal, Claire M Grant, Harry M Georgiou

Conference Proceedings | 2019 | American Journal of Obstetrics and Gynecology

Low-dose aspirin treatment enhances the adhesion of preeclamptic decidual mesenchymal stem/stromal cells and reduces their production of pro-inflammatory cytokines

Ramin Khanabdali, Aida Shakouri-Motlagh, Sarah Wilkinson, Padma Murthi, Harry M Georgiou, Shaun P Brennecke, Bill Kalionis

Journal article | 2018 | Journal of Molecular Medicine

Clinical features and outcomes of pregnancies complicated by pre-ecplampsia necessitating in-utero transfer

Stephanie E Reilly, Shaun P Brennecke, Jacqui Smith, Michael J Stewart, Rosemarie A Boland

Journal article | 2018 | Pregnancy Hypertension

How Safe is Outpatient Management of Major Placenta Praevia Near Term?

L Jayawardena, S Brennecke, L Rigg

Conference Proceedings | 2018 | AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

Does Maternal Serum C-Reactive Protein (CRP) Predict Histological Severity of Fetal Inflammation in Preterm Prelabour Rupture of Membranes (PPROM)?

M Pattanasri, S Brennecke

Conference Proceedings | 2018 | AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

THE EFFECT OF LOW DOSE ASPIRIN ON DECIDUAL DERIVED MESENCHYMAL STEM/STROMAL CELLS IN PREECLAMPSIA

Ramin Khanabdali, Aida Shakouri-Motlagh, Sarah Wilkinson, Harry Georgiou, Shaun Brennecke, Bill Kalionis

Conference Proceedings | 2018 | PLACENTA

Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks' gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study

Teresa M MacDonald, Tran Chuong, Tu'uhevaha J Kaitu'u-Lino, Shaun P Brennecke, Richard J Hiscock, Lisa Hui, Kirsten M Dane, Anna L Middleton, Ping Cannon, Susan P Walker, Stephen Tong

Journal article | 2018 | BMC PREGNANCY AND CHILDBIRTH

Setting the pace for labour

Helena C Parkington, Penelope M Sheehan, Harold A Coleman, Shaun P Brennecke

Journal article | 2018 | The Journal of Physiology

Transferable Matrixes Produced from Decellularized Extracellular Matrix Promote Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells and Facilitate Scale-Up

Gina D Kusuma, Michael C Yang, Shaun P Brennecke, Andrea J O'Connor, Bill Kalionis, Daniel E Heath

Journal article | 2018 | ACS Biomaterials Science & Engineering

Decidual ACVR2A regulates extravillous trophoblast functions of adhesion, proliferation, migration and invasion in vitro

Hannah EJ Yong, Padma Murthi, Bill Kalionis, Rosemary J Keogh, Shaun P Brennecke

Journal article | 2018 | Pregnancy Hypertension

Accuracy of second trimester prediction of preterm preeclampsia by three different screening algorithms

Ahmed Al-Amin, Daniel Lorber Rolnik, Carin Black, Adrienne White, Caroline Stolarek, Shaun Brennecke, Fabricio da Silva Costa

Journal article | 2018 | Australian and New Zealand Journal of Obstetrics and Gynaecology

Expression of Homeobox Gene HLX and its Downstream Target Genes are Altered in Placentae From Discordant Twin Pregnancies

Nicola Yuen, Shaun P Brennecke, Mark P Umstad, Hannah EJ Yong, Anthony J Borg, Gayathri Rajaraman, Bill Kalionis, Padma Murthi

Journal article | 2018 | Twin Research and Human Genetics

Altered downstream target gene expression of the placental Vitamin D receptor in human idiopathic fetal growth restriction

Thy PH Nguyen, Hannah EJ Yong, Tejasvy Chollangi, Shaun P Brennecke, Susan J Fisher, Euan M Wallace, Peter R Ebeling, Padma Murthi

Journal article | 2018 | Cell Cycle

Genetic Approaches in Preeclampsia

Hannah EJ Yong, Padma Murthi, Shaun P Brennecke, Eric K Moses

Book Chapter | 2018 | Methods in Molecular Biology

Melanoma in pregnancy

Rebecca Still, Shaun Brennecke

Journal article | 2017 | Obstetric Medicine

Understanding the Role of Mesenchymal Stem/Stromal Cells in Ageing of the Human Placenta

Ramin Khanabdali, Harry Georgiou, Shaun Brennecke, Bill Kalionis

Conference Proceedings | 2017 | Mechanisms of Development

Antiangiogenic effects of decorin restored by unfractionated, low molecular weight, and nonanticoagulant heparins

Amy KL Chui, Tilini N Gunatillake, Vera Ignjatovic, Paul T Monagle, Padma Murthi, Shaun P Brennecke, John M Whitelock, Joanne M Said

Journal article | 2017 | Blood Advances

Native and solubilized decellularized extracellular matrix: A critical assessment of their potential for improving the expansion of mesenchymal stem cells

Aida Shakouri-Motlagh, Andrea J O'Connor, Shaun P Brennecke, Bill Kalionis, Daniel E Heath

Journal article | 2017 | Acta Biomaterialia

Expression of Biglycan in First Trimester Chorionic Villous Sampling Placental Samples and Altered Function in Telomerase-Immortalized Microvascular Endothelial Cells

Amy Chui, Tilini Gunatillake, Shaun P Brennecke, Vera Ignjatovic, Paul T Monagle, John M Whitelock, Dagmar E van Zanten, Jasper Eijsink, Yao Wang, James Deane, Anthony J Borg, Janet Stevenson, Jan Jaap Erwich, Joanne M Said, Padma Murthi

Journal article | 2017 | Arteriosclerosis, Thrombosis, and Vascular Biology

Mother Nature versus Father Time

Helena C Parkington, Penelope M Sheehan, Harold A Coleman, Shaun P Brennecke

Journal article | 2017 | The Journal of Physiology

Reduced aldehyde dehydrogenase expression in preeclamptic decidual mesenchymal stem/stromal cells is restored by aldehyde dehydrogenase agonists

Gina D Kusuma, Mohamed H Abumaree, Anthony V Perkins, Shaun P Brennecke, Bill Kalionis

Journal article | 2017 | SCIENTIFIC REPORTS

Decellularized extracellular matrices produced from immortal cell lines derived from different parts of the placenta support primary mesenchymal stem cell expansion

Gina D Kusuma, Shaun P Brennecke, Andrea J O'Connor, Bill Kalionis, Daniel E Heath

Journal article | 2017 | PLOS ONE

Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction

Alice F Wookey, Tejasvy Chollangi, Hannah EJ Yong, Bill Kalionis, Shaun P Brennecke, Padma Murthi, Harry M Georgiou

Journal article | 2017 | JOURNAL OF PREGNANCY

The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia

Liv Cecilie V Thomsen, Nina S McCarthy, Phillip E Melton, Gemma Cadby, Rigmor Austgulen, Ottar K Nygard, Matthew P Johnson, Shaun Brennecke, Eric K Moses, Line Bjorge, Ann-Charlotte Iversen

Journal article | 2017 | JOURNAL OF HYPERTENSION

Ophthalmic artery Doppler analysis: a window into the cerebrovasculature of women with pre-eclampsia

SC Kane, SP Brennecke, F Da Silva Costa

Journal article | 2017 | Ultrasound in Obstetrics & Gynecology

Understanding the role of Mesenchymal Stem/Stromal Cells in ageing of the human placenta

R Khanabdali, HM Georgiou, SP Brennecke, B Kalionis

Conference Proceedings | 2017 | Mechanisms of Development

Implantation of the sFlt-1/PlGF ratio for the prediction and diagnosis of preeclampsia in single pregnancies: Implications for clinical practice

H Stepan, I Herraiz, D Schlembach, S Verlohren, S Brennecke, F Chantraine, E Klein, O Lapaire, E Llurba, A Ramoni, M Vatish, D Wertaschnigg, A Galindo

Journal article | 2017 | Progresos de Obstetricia y Ginecologia

Low-Dose Acetylsalicylic Acid Treatment Modulates the Production of Cytokines and Improves Trophoblast Function in an in Vitro Model of Early-Onset Preeclampsia

Shanika Panagodage, Hannah EJ Yong, Fabricio Da Silva Costa, Anthony J Borg, Bill Kalionis, Shaun P Brennecke, Padma Murthi

Journal article | 2016 | The American Journal of Pathology

Decorin expression is decreased in first trimester placental tissue from pregnancies with small for gestation age infants at birth

P Murthi, DE van Zanten, JJH Eijsink, AJ Borg, JL Stevenson, B Kalionis, AK Chui, JM Said, SP Brennecke, JJHM Emrich

Journal article | 2016 | Placenta

LOW-DOSE ASPIRIN IMPROVES TGF beta 1-MEDIATED TROPHOBLAST PROLIFERATION AND MIGRATION IN AN IN VITRO MODEL OF PREECLAMPSIA

Jessica E Davies, Hannah EJ Yong, Anthony J Borg, Shaun P Brennecke, Padma Murthi

Conference Proceedings | 2016 | Placenta

Soluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio and Time to Delivery in Women With Suspected Preeclampsia

Harald Zeisler, Elisa Llurba, Frederic Chantraine, Manu Vatish, Anne Cathrine Staff, Maria Sennstrom, Matts Olovsson, Shaun P Brennecke, Holger Stepan, Deirdre Allegranza, Carina Dinkel, Maria Schoedl, Peter Dilba, Martin Hund, Stefan Verlohren

Journal article | 2016 | Obstetrics & Gynecology

Mesenchymal Stem/Stromal Cells Derived From a Reproductive Tissue Niche Under Oxidative Stress Have High Aldehyde Dehydrogenase Activity

Gina D Kusuma, Mohamed H Abumaree, Mark D Pertile, Anthony V Perkins, Shaun P Brennecke, Bill Kalionis

Journal article | 2016 | Stem Cell Reviews and Reports

Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia

H Zeisler, E Llurba, F Chantraine, M Vatish, AC Staff, M Sennström, M Olovsson, SP Brennecke, H Stepan, D Allegranza, P Dilba, M Schoedl, M Hund, S Verlohren

Journal article | 2016 | Obstetrical & Gynecological Survey

Cyclosporin A significantly improves preeclampsia signs and suppresses inflammation in a rat model

Bihui Hu, Jinying Yang, Qian Huang, Junjie Bao, Shaun Patrick Brennecke, Huishu Liu

Journal article | 2016 | Cytokine

Predictive Value of the sFlt-1: PlGF Ratio in Women With Suspected Preeclampsia EDITORIAL COMMENT

Harald Zeisler, Elisa Llurba, Frederic Chantraine, Manu Vatish, Anne Cathrine Staff, Maria Sennstrom, Matts Olovsson, Shaun P Brennecke, Holger Stepan, Deirdre Allegranza, Peter Dilba, Maria Schoedl, Martin Hund, Stefan Verlohren

Journal article | 2016 | OBSTETRICAL & GYNECOLOGICAL SURVEY

Establishment and characterization of fetal and maternal mesenchymal stem/stromal cell lines from the human term placenta

Sharon Q Qin, Gina D Kusuma, Batla Al-Sowayan, Rishika A Pace, Sandra Isenmann, Mark D Pertile, Stan Gronthos, Mohamed H Abumaree, Shaun P Brennecke, Bill Kalionis

Journal article | 2016 | Placenta

Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia

Harald Zeisler, Elisa Llurba, Frederic Chantraine, Manu Vatish, Anne Cathrine Staff, Maria Sennstrom, Matts Olovsson, Shaun P Brennecke, Holger Stepan, Deirdre Allegranza, Peter Dilba, Maria Schoedl, Martin Hund, Stefan Verlohren

Journal article | 2016 | New England Journal of Medicine

Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes

Tea Kaartokallio, A Inkeri Lokki, Hanna Peterson, Katja Kivinen, Leena Hiltunen, Elina Salmela, Tuuli Lappalainen, Paula Maanselka, Sanna Heino, Sakari Knuutila, Ayat Sayed, Lucilla Poston, Shaun P Brennecke, Matthew P Johnson, Linda Morgan, Eric K Moses, Juha Kere, Hannele Laivuori

Journal article | 2016 | Annals of Medicine

Changes in myometrial expression of progesterone receptor membrane components 1 and 2 are associated with human parturition at term

Ray Wang, Penelope M Sheehan, Shaun P Brennecke

Journal article | 2016 | Reproduction, Fertility and Development

Protocol for a randomised controlled trial of fetal scalp blood lactate measurement to reduce caesarean sections during labour: the Flamingo trial [ACTRN12611000172909]

Christine E East, Stefan C Kane, Mary-Ann Davey, C Omar Kamlin, Shaun P Brennecke

Journal article | 2015 | BMC PREGNANCY AND CHILDBIRTH

Anti-angiogenic collagen fragment arresten is increased from 16 weeks' gestation in pre-eclamptic plasma

Hannah EJ Yong, Padma Murthi, May H Wong, Bill Kalionis, Shaun P Brennecke, Rosemary J Keogh

Journal article | 2015 | Placenta

Ectopic Bone Formation by Mesenchymal Stem Cells Derived from Human Term Placenta and the Decidua

Gina D Kusuma, Danijela Menicanin, Stan Gronthos, Ursula Manuelpillai, Mohamed H Abumaree, Mark D Pertile, Shaun P Brennecke, Bill Kalionis

Journal article | 2015 | PLOS ONE

Effects of normal and high circulating concentrations of activin A on vascular endothelial cell functions and vasoactive factor production

Hannah EJ Yong, Padma Murthi, May H Wong, Bill Kalionis, Judith E Cartwright, Shaun P Brennecke, Rosemary J Keogh

Journal article | 2015 | Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

DECREASED PLACENTAL VITAMIN D RECEPTOR CONTRIBUTES TO ABERRANT CELL-CYCLE GENE REGULATION IN HUMAN IDIOPATHIC FETAL GROWTH RESTRICTION

Nguyen Thy, Hannah Yong, Anthony Borg, Shaun Brennecke, Padma Murthi

Conference Proceedings | 2015 | Placenta

Placental vitamin D receptor expression is decreased in human idiopathic fetal growth restriction

TPH Nguyen, HEJ Yong, T Chollangi, AJ Borg, SP Brennecke, P Murthi

Journal article | 2015 | Journal of Molecular Medicine

Genome-Wide Transcriptome Directed Pathway Analysis of Maternal Pre-Eclampsia Susceptibility Genes

Hannah EJ Yong, Phillip E Melton, Matthew P Johnson, Katy A Freed, Bill Kalionis, Padma Murthi, Shaun P Brennecke, Rosemary J Keogh, Eric K Moses

Journal article | 2015 | PLOS ONE

Mechanistic insights into dysfunctional labour in women with high body mass index

SP Brennecke, PM Sheehan, HA Coleman, HC Parkington

Conference Proceedings | 2015 | BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Implementation of the sFlt-1/PIGF ratio for prediction and diagnosis of pre-eclampsia in singleton pregnancy: implications for clinical practice

H Stepan, I Herraiz, D Schlembach, S Verlohren, S Brennecke, F Chantraine, E Klein, O Lapaire, E Llurba, A Ramoni, M Vatish, D Wertaschnigg, A Galindo

Journal article | 2015 | ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Mesenchymal stem cells reside in a vascular niche in the decidua basalis and are absent in remodelled spiral arterioles

GD Kusuma, U Manuelpillai, MH Abumaree, MD Pertile, SP Brennecke, B Kalionis

Journal article | 2015 | Placenta

First-Trimester Uterine Artery Doppler Analysis in the Prediction of Later Pregnancy Complications

Su Lynn Khong, Stefan C Kane, Shaun P Brennecke, Fabricio da Silva Costa

Journal article | 2015 | DISEASE MARKERS

Predicting Preterm Labour: Current Status and Future Prospects

Harry M Georgiou, Megan KW Di Quinzio, Michael Permezel, Shaun P Brennecke

Journal article | 2015 | DISEASE MARKERS

[289-POS]: Placental heparan sulphate glycosaminoglycans in pre-eclampsia.

T Gunatillake, A Chui, M Lord, J Whitelock, P Murthi, V Ignatovic, P Monagle, S Brennecke, J Said

Conference Proceedings | 2015 | Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

OBJECTIVES: Pre-eclampsia (PE) is a serious pregnancy complication which affects 3-5% of the pregnant population. To date there is..

ACTIVIN A CONTRIBUTES TO THE VASCULAR ENDOTHELIAL DYSFUNCTION OF PRE-ECLAMPSIA

Hannah EJ Yong, Padma Murthi, May H Wong, Bill Kalionis, Shaun P Brennecke, Rosemary J Keogh

Conference Proceedings | 2014 | Placenta

EFFECT OF LOW-DOSE ASPIRIN ON IN VITRO EXPRESSION OF ENDOCAN IN PRE-ECLAMPSIA

Anita Pratt, Anthony Borg, Rosemary Keogh, Jeff Keelan, Larry Chamley, Shaun Brennecke, Joanne Said, Padma Murthi

Conference Proceedings | 2014 | Placenta

Re: New directions in the prediction of pre-eclampsia

Stefan C Kane, Fabricio Da Silva Costa, Shaun P Brennecke

Journal article | 2014 | Australian and New Zealand Journal of Obstetrics and Gynaecology

Altered decorin leads to disrupted endothelial cell function: A possible mechanism in the pathogenesis of fetal growth restriction?

A Chui, P Murthi, T Gunatillake, SP Brennecke, V Ignjatovic, PT Monagle, JM Whitelock, JM Said

Journal article | 2014 | Placenta

Diminished hERG K channel activity facilitates strong human labour contractions but is dysregulated in obese women

Helena C Parkington, Janet Stevenson, Mary A Tonta, Jonathan Paul, Trent Butler, Kaushik Maiti, Eng-Cheng Chan, Penelope M Sheehan, Shaun P Brennecke, Harold A Coleman, Roger Smith

Journal article | 2014 | Nature Communications

New directions in the prediction of pre-eclampsia

Stefan C Kane, Fabricio Da Silva Costa, Shaun P Brennecke

Journal article | 2014 | Australian and New Zealand Journal of Obstetrics and Gynaecology

Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22

Mari Loset, Matthew P Johnson, Phillip E Melton, Wei Ang, Rae-Chi Huang, Trevor A Mori, Lawrence J Beilin, Craig Pennell, Linda T Roten, Ann-Charlotte Iversen, Rigmor Austgulen, Christine E East, John Blangero, Shaun P Brennecke, Eric K Moses

Journal article | 2014 | Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

An Eclampsia-Like Model Induced in Pregnant Rats with Lipolysaccharide and Pentylenetetrazol Treatments.

Qian Huang, Lei Liu, Bihui Hu, Xiaodan Di, Shaun Patrick Brennecke, Huishu Liu

Conference Proceedings | 2014 | REPRODUCTIVE SCIENCES

Decreased Seizure Threshold in an Eclampsia-Like Model Induced in Pregnant Rats with Lipopolysaccharide and Pentylenetetrazol Treatments

Qian Huang, Lei Liu, Bihui Hu, Xiaodan Di, Shaun Patrick Brennecke, Huishu Liu

Journal article | 2014 | PLoS One

Recent developments in early pregnancy screening: are we getting closer to the Holy Grail?

Stefan C Kane, Fabricio Da Silva Costa, Shaun P Brennecke

Journal article | 2014 | MEDICAL JOURNAL OF AUSTRALIA

Increased decidual mRNA expression levels of candidate maternal preeclampsia susceptibility genes are associated with clinical severity

HEJ Yong, P Murthi, A Borg, B Kalionis, EK Moses, SP Brennecke, RJ Keogh

Journal article | 2014 | Placenta

First Trimester Biomarkers in the Prediction of Later Pregnancy Complications

Stefan C Kane, Fabricio da Silva Costa, Shaun Brennecke

Journal article | 2014 | BIOMED RESEARCH INTERNATIONAL

Low-dose aspirin improves trophoblastic function in early-onset pre-eclampsia

Fabricio da Silva Costa, Shanika Panagodage, Shaun Brennecke, Padma Murthi

Conference Proceedings | 2014 | AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Homeobox gene transforming growth factor -induced factor-1 (TGIF-1) is a regulator of villous trophoblast differentiation and its expression is increased in human idiopathic fetal growth restriction

Niroshani A Pathirage, Melanie Cocquebert, Yoel Sadovsky, Mohamed Abumaree, Ursula Manuelpillai, Anthony Borg, Rosemary J Keogh, Shaun P Brennecke, Daniele Evain-Brion, Thierry Fournier, Bill Kalionis, Padma Murthi

Journal article | 2013 | MOLECULAR HUMAN REPRODUCTION

A Case of Adenomyosis with a High Titer of IgG Autoantibody to Calreticulin.

Neil M Gude, Janet L Stevenson, Penelope M Sheehan, Shaun P Brennecke

Journal article | 2013 | J Investig Med High Impact Case Rep

Background. High prevalence of autoantibodies to the calcium-binding, endoplasmic reticulum chaperone protein calreticulin has bee..

Downstream targets of the homeobox gene DLX3 are differentially expressed in the placentae of pregnancies affected by human idiopathic fetal growth restriction

Amy Chui, Bill Kalionis, Mohamed Abumaree, Melanie Cocquebert, Thierry Fournier, Daniele Evain-Brion, Shaun P Brennecke, Padma Murthi

Journal article | 2013 | MOLECULAR AND CELLULAR ENDOCRINOLOGY

UNFRACTIONATED HEPARIN REVERSES THE INCREASED THROMBIN GENERATION ASSOCIATED WITH DECORIN DEFICIENCY IN FETAL GROWTH RESTRICTION

Amy Chui, Tilini Gunatillake, Padma Murthi, Vera Ignjatovic, Paul Monagle, John Whitelock, Shaun Brennecke, Joanne Said

Conference Proceedings | 2013 | Placenta

THE FUNCTIONAL EFFECT OF SYNDECAN 1 DEFICIENCY IN BEWO CELLS AND ITS IMPLICATIONS IN FETAL GROWTH RESTRICTION

Tilini Gunatillake, Amy Chui, Padma Murthi, Vera Ignjatovic, Paul Monagle, John Whitelock, Shaun Brennecke, Joanne Said

Conference Proceedings | 2013 | Placenta

DECIDUAL MESENCHYMAL STEM CELLS HAVE REDUCED RESISTANCE TO OXIDATIVE STRESS IN PREECLAMPSIA, WHICH IS RESTORED BY THE ALDEHYDE DEHYDROGENASE AGONIST ALDA-1

Gina Kusuma, Mohamed Abumaree, Shaun Brennecke, Bill Kalionis

Conference Proceedings | 2013 | Placenta

DECREASED VDR EXPRESSION CONTRIBUTES TO REDUCED FETO-PLACENTAL GROWTH IN IDIOPATHIC HUMAN FETAL GROWTH RESTRICTION

Tejasvy Cholangi, Hannah Yong, Nguyen Thy, Anthony Borg, Shaun Brennecke, Padma Murthi

Conference Proceedings | 2013 | Placenta

Genetic dissection of the pre-eclampsia susceptibility locus on chromosome 2q22 reveals shared novel risk factors for cardiovascular disease

Matthew P Johnson, Shaun P Brennecke, Christine E East, Thomas D Dyer, Linda T Roten, J Michael Proffitt, Phillip E Melton, Mona H Fenstad, Tia Aalto-Viljakainen, Kaarin Makikallio, Seppo Heinonen, Eero Kajantie, Juha Kere, Hannele Laivuori, Rigmor Austgulen, John Blangero, Eric K Moses

Journal article | 2013 | Molecular Human Reproduction

Control of extravillous trophoblast function by the eotaxins CCL11, CCL24 and CCL26

Simon E Chau, Padma Murthi, May H Wong, Guy StJ Whitley, Shaun P Brennecke, Rosemary J Keogh

Journal article | 2013 | Human Reproduction

PP024. Effects of intravenous magnesium sulfate on the characteristics of eclamptic seizures induced by electrical stimuli in a rat preeclampsia/eclampsia model.

Lei Liu, Huishu Liu, Qian Huang, Shaun Brennecke, Bihui Hu

Journal article | 2013 | Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

BACKGROUND/AIMS: Eclampsia is a serious complication of pregnancy and remains a leading cause of maternal mortality worldwide. Mag..

OP004. A SNP associated with susceptibility to preeclampsia near the inhibin, beta B gene, is also associated with cardiovascular disease risk traits.

Mari Løset, Matthew P Johnson, Phillip E Melton, Wei Ang, Julie Marsh, Rae-Chi Huang, Trevor Mori, Lawrence Beilin, Craig Pennell, Linda T Roten, Ann-Charlotte Iversen, Rigmor Austgulen, Christine E East, John Blangero, Shaun P Brennecke, Eric K Moses

Journal article | 2013 | Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

INTRODUCTION: It is well established that preeclampsia (PE) increases later life cardiovascular disease (CVD) risk. Consequently, ..

PP023. Soluble Fms-like tyrosine kinase-1 and placental growth factor expression in a rat model of pre-eclampsia.

Lei Liu, Huishu Liu, Shaun Brennecke, Qian Huang, Bihui Hu

Journal article | 2013 | Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

BACKGROUND/AIMS: Soluble Fms-like tyrosine kinase-1(sFlt-1) and placental growth factor (PIGF) have been used clinically to predic..

Altered Decorin Expression Leads to Disrupted Vascular Endothelial Cell Functions: A Potential Mechanism in the Pathogenesis of Human Fetal Growth Restriction

Amy KL Chui, Padma Murthi, Shaun P Brennecke, Vera Ignjatovic, Paul T Monagle, Joanne M Said

Conference Proceedings | 2013 | REPRODUCTIVE SCIENCES

Contemporary clinical management of the cerebral complications of preeclampsia.

Stefan C Kane, Alicia Dennis, Fabricio da Silva Costa, Louise Kornman, Shaun Brennecke

Journal article | 2013 | Obstet Gynecol Int

The neurological complications of preeclampsia and eclampsia are responsible for a major proportion of the morbidity and mortality..

Decidua Parietalis-Derived Mesenchymal Stromal Cells Reside in a Vascular Niche Within the Choriodecidua

NM Castrechini, P Murthi, S Qin, GD Kusuma, L Wilton, M Abumaree, S Gronthos, A Zannettino, NM Gude, SP Brennecke, B Kalionis

Journal article | 2012 | Reproductive Sciences

Placental CLIC3 is increased in fetal growth restriction and pre-eclampsia affected human pregnancies

P Murthi, JL Stevenson, TT Money, AJ Borg, SP Brennecke, NM Gude

Journal article | 2012 | Placenta

VASCULAR SMOOTH MUSCLE CELLS FROM SPIRAL ARTERIOLES PRODUCE CHEMOKINES WHICH REGULATE EXTRAVILLOUS TROPHOBIAST CELL MIGRATION

Simon Chau, Padma Murthi, May Wong, Shaun Brennecke, Rosemary Keogh

Conference Proceedings | 2012 | PLACENTA

DECREASED EXPRESSION OF PROGESTERONE RECEPTOR (PGR) IS ASSOCIATED WITH HUMAN IDIOPATHIC FETAL GROWTH RESTRICTION

Padma Murthi, Anthony Borg, Janet Stevenson, Penny Sheehan, Shaun Brennecke

Conference Proceedings | 2012 | PLACENTA

OS077. The chromosome 2q22 preeclampsia susceptibility locus reveals shared novel risk factors for CVD.

E Moses, M Johnson, C East, T Dyer, L Roten, J Proffitt, M Fenstad, T Aalto-Viljakainen, K Mäkikallio, S Heinonen, E Kajantie, J Kere, H Laivuori, R Austgulen, J Blangero, S Brennecke