Laila Huq

Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains

Christine A Seers, A Sayeed M Mahmud, N Laila Huq, Keith J Cross, Eric C Reynolds

Journal article  |  2021  |  JOURNAL OF ORAL MICROBIOLOGY

Background: The cell-surface cysteine proteinases RgpA, RgpB (Arg-gingipain), and Kgp (Lys-gingipain) are major virulence factors ..

Molecular Interactions of Peptide Encapsulated Calcium Phosphate Delivery Vehicle at Enamel Surfaces

NL Huq, KJ Cross, H Myroforidis, DP Stanton, YY Chen, BR Ward, EC Reynolds

Book Chapter  |  2018

Phosphorylated peptides derived from milk caseins, known as casein phosphopeptides (CPP) self-assemble and encapsulate the calcium..

Porphyromonas gingivalis Gingipains Display Transpeptidation Activity

Lianyi Zhang, Paul D Veith, N Laila Huq, Yu-Yen Chen, Christine A Seers, Keith J Cross, Dhana G Gorasia, Eric C Reynolds

Journal article  |  2018  |  JOURNAL OF PROTEOME RESEARCH

Porphyromonas gingivalis is a keystone periodontal pathogen that has been associated with autoimmune disorders. The cell surface p..

Interplay between Porphyromonas gingivalis and EGF signalling in the regulation of CXCL14

Jiamin Aw, Glen M Scholz, Noorjahan Laila Huq, Jennifer Huynh, Neil M O'Brien-Simpson, Eric C Reynolds

Journal article  |  2018  |  CELLULAR MICROBIOLOGY

Porphyromonas gingivalis is a keystone pathogen in chronic periodontitis. Its expression of gingipain proteases (Kgp and RgpA/B) i..

Physico-chemical Characterisation of the Processes Involved in Enamel Remineralisation by CPP-ACP

Keith Cross, Noorjahan Laila Huq, Boon Loh, Li-Ming Bhutta, Bill Madytianos, Sarah Peterson, David Phillip Stanton, Yi Yuan, Coralie Reynolds, Glen Walker, Peiyan Shen, Eric Charles Reynolds

Book Chapter  |  2018

Casein Phosphopeptide-Amorphous Calcium Phosphate Reduces Streptococcus mutans Biofilm Development on Glass Ionomer Cement and Disrupts Established Biofilms

Stuart G Dashper, Deanne V Catmull, Sze-Wei Liu, Helen Myroforidis, Ilya Zalizniak, Joseph EA Palamara, N Laila Huq, Eric C Reynolds

Journal article  |  2016  |  PLOS ONE

Glass ionomer cements (GIC) are dental restorative materials that are suitable for modification to help prevent dental plaque (bio..

Casein Phosphopeptide-Amorphous Calcium Phosphate Nanocomplexes: A Structural Model

Keith J Cross, N Laila Huq, Eric C Reynolds

Journal article  |  2016  |  BIOCHEMISTRY

Tryptic digestion of the calcium-sensitive caseins yields casein phosphopeptides (CPP) that contain clusters of phosphorylated ser..

The Interactions of CPP-ACP with Saliva

Noorjahan Laila Huq, Helen Myroforidis, Keith J Cross, David P Stanton, Paul D Veith, Brent R Ward, Eric C Reynolds

Journal article  |  2016  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The repair of early dental caries lesions has been demonstrated by the application of the remineralisation technology based on cas..

Bioinformatic investigation of the cost management strategies of five oral microbes

KJ Cross, NL Huq, SH Park, JS Park, P Pham, M Quah, M Ranjan, EC Reynolds

Journal article  |  2015  |  MOLECULAR ORAL MICROBIOLOGY

Some amino acids are more energetically costly to synthesize de novo, therefore many microbes have evolved to regulate the metabol..

Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health

Michael A Gorman, Christine A Seers, Belinda J Michell, Susanne C Feil, N Laila Huq, Keith J Cross, Eric C Reynolds, Michael W Parker

Journal article  |  2015  |  PROTEIN SCIENCE

The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the pri..