Darren Kelly

Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model

Mark T Waddingham, Takashi Sonobe, Hirotsugu Tsuchimochi, Amanda J Edgley, Vijayakumar Sukumaran, Yi Ching Chen, Sarabjit S Hansra, Daryl O Schwenke, Keiji Umetani, Kohki Aoyama, Naoto Yagi, Darren J Kelly, Shahrooz Gaderih, Melissa Herwig, Detmar Kolijn, Andreas Muegge, Walter J Paulus, Takeshi Ogo, Mikiyasu Shirai, Nazha Hamdani, et al.

Journal article  |  2019  |  Journal of Molecular and Cellular Cardiology

Coronary microvessel endothelial dysfunction and nitric oxide (NO) depletion contribute to elevated passive tension of cardiomyocy..

Oral administration of the novel small molecule drug OCX063 protects against inflammation and vascular pathology in a rat diabetic retinopathy (DR) model

Roy Chze Khai Kong, Amanda Edgley, Elsa Chan, Alison J Cox, Sylwia Glowacka, Michelle Papadimitriou, Fay Lin Khong, Darren Kelly

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Inhibition of apoptosis signal-regulating kinase 1 ameliorates cardiac dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome

F Savira, BH Wang, AJ Edgley, H Krum, DJ Kelly, AR Kompa

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF HEART FAILURE

The role of dihydrosphingolipids in disease

Ruth R Magaye, Feby Savira, Yue Hua, Darren J Kelly, Christopher Reid, Bernard Flynn, Danny Liew, Bing H Wang

Journal article  |  2019  |  Cellular and Molecular Life Sciences

Inhibition of Apoptosis Signal-Regulating Kinase 1 Attenuates Myocyte Hypertrophy and Fibroblast Collagen Synthesis

Wendi Yang, Bing Hui Wang, Ian Wang, Li Huang, Feby Savira, Andrew Kompa, Beat M Jucker, Robert N Willette, Darren Kelly, Henry Krum, Zhiliang Li, Qian Fu

Journal article  |  2019  |  Heart, Lung and Circulation

Prescription of physical activity in the management of high blood pressure in Australian general practices

Ben J Smith, Alice J Owen, Danny Liew, Darren J Kelly, Christopher M Reid

Journal article  |  2019  |  Journal of Human Hypertension

The Challenges of Stem Cell Therapy in Myocardial Infarction and Heart Failure and the Potential Strategies to Improve the Outcomes

Bing Hui Wang, Danny Liew, Kevin W Huang, Li Huang, Wenjie Tang, Darren J Kelly, Christopher Reid, Zhongmin Liu

Journal article  |  2018  |  Nano LIFE

Cost-Effectiveness of Rena Denervation Therapy for Treatment-Resistant Hypertension: A Best Case Scenario

Enayet Karim Chowdhury, Christopher M Reid, Ella Zomer, Darren J Kelly, Danny Liew

Journal article  |  2018  |  American Journal of Hypertension

COST-EFFECTIVENESS OF RENAL DENERVATION THERAPY FOR TREATMENT RESISTANT HYPERTENSION: A BEST CASE SCENARIO

EK Chowdhury, CM Reid, E Zoomer, DJ Kelly, D Liew

Conference Proceedings  |  2018  |  Journal of Hypertension

Angiotensin receptor neprilysin inhibition provides superior cardioprotection compared to angiotensin converting enzyme inhibition after experimental myocardial infarction

Andrew R Kompa, Jiayu Lu, Thomas J Weller, Darren J Kelly, Henry Krum, Thomas G von Lueder, Bing H Wang

Journal article  |  2018  |  International Journal of Cardiology

Changes in titin phosphorylation and PKG activity underlie diastolic dysfunction at the cross-bridge level in the early stages of type 2 diabetes

MT Waddingham, N Hamdani, AJ Edgley, H Tsuchimochi, T Sonobe, DJ Kelly, N Yagi, WJ Paulus, M Shirai, JT Pearson

Conference Proceedings  |  2018  |  EUROPEAN JOURNAL OF HEART FAILURE

Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome.

Sven Y Surikow, Thanh H Nguyen, Irene Stafford, Matthew Chapman, Sujith Chacko, Kuljit Singh, Giovanni Licari, Betty Raman, Darren J Kelly, Yuan Zhang, Mark T Waddingham, Doan T Ngo, Alexander P Bate, Su Jen Chua, Michael P Frenneaux, John D Horowitz

Journal article  |  2018  |  JACC: Basic to Translational Science

Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem st..

Chronic kidney disease with comorbid cardiac dysfunction exacerbates cardiac and renal damage

Shan Liu, Bing H Wang, Darren J Kelly, Henry Krum, Andrew R Kompa

Journal article  |  2018  |  Journal of Cellular and Molecular Medicine

Widespread Coronary Dysfunction in the Absence of HDL Receptor SR-B1 in an Ischemic Cardiomyopathy Mouse Model

James T Pearson, Misa Yoshimoto, Yi Ching Chen, Rohullah Sultani, Amanda J Edgley, Hajime Nakaoka, Makoto Nishida, Keiji Umetani, Mark T Waddingham, Hui-Ling Jin, Yuan Zhang, Darren J Kelly, Daryl O Schwenke, Tadakatsu Inagaki, Hirotsugu Tsuchimochi, Issei Komuro, Shizuya Yamashita, Mikiyasu Shirai

Journal article  |  2017  |  Scientific Reports

Cardiac fibrosis in the ageing heart: Contributors and mechanisms

Lu Lu, Jingbin Guo, Yue Hua, Kevin Huang, Ruth Magaye, Jake Cornell, Darren J Kelly, Christopher Reid, Danny Liew, Yingchun Zhou, Aihua Chen, Wei Xiao, Qiang Fu, Bing Hui Wang

Journal article  |  2017  |  Clinical and Experimental Pharmacology and Physiology

OCX063, A Novel Small Molecule Drug, Exhibits Anti-Inflammatory and Anti-Fibrotic Properties in Retinal Cultures

Roy Chze Khai Chze Khai Kong, Alison J Cox, Sylwia Glowacka, Darren J Kelly, Fay Khong

Conference Proceedings  |  2017  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

The protective effect of OCX063 on reducing neovascularization and lesion size in a mouse model of choroidal neovascularization.

Erica L Fletcher, Alice A Brandli, Roy Kong, Fay Khong, Darren J Kelly

Conference Proceedings  |  2017  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Angiotensin receptor neprilysin inhibitor LCZ696: pharmacology, pharmacokinetics and clinical development

Yue Hua, Ian Wang, Bin Liu, Darren J Kelly, Christopher Reid, Danny Liew, Yingchun Zhou, Bing H Wang

Journal article  |  2017  |  Future Cardiology

Renal cellular hypoxia in adenine-induced chronic kidney disease

Debra Fong, Md Mahbub Ullah, Jaswini G Lal, Amany Abdelkader, Connie PC Ow, Lucinda M Hilliard, Sharon D Ricardo, Darren J Kelly, Roger G Evans

Journal article  |  2016  |  Clinical and Experimental Pharmacology and Physiology

Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin-resistant Goto-Kakizaki rats

Yi Ching Chen, Tadakatsu Inagaki, Yutaka Fujii, Daryl O Schwenke, Hirotsugu Tsuchimochi, Amanda J Edgley, Keiji Umetani, Yuan Zhang, Darren J Kelly, Misa Yoshimoto, Hisashi Nagai, Roger G Evans, Ichiro Kuwahira, Mikiyasu Shirai, James T Pearson

Journal article  |  2016  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway

Chunling Huang, Yuan Zhang, Darren J Kelly, Christina YR Tan, Anthony Gill, Delfine Cheng, Filip Braet, Jin-Sung Park, Carolyn M Sue, Carol A Pollock, Xin-Ming Chen

Journal article  |  2016  |  Scientific Reports

Calibrated integrated backscatter and myocardial fibrosis in patients undergoing cardiac surgery

David L Prior, Jithendra B Somaratne, Alicia J Jenkins, Michael Yii, Andrew E Newcomb, Casper G Schalkwijk, Mary J Black, Darren J Kelly, Duncan J Campbell

Journal article  |  2015  |  Open Heart

Cardiac Repair With a Novel Population of Mesenchymal Stem Cells Resident in the Human Heart

Yuan Zhang, Priyadharshini Sivakumaran, Andrew E Newcomb, Damian Hernandez, Nicole Harris, Ramin Khanabdali, Guei-Sheung Liu, Darren J Kelly, Alice Pebay, Alex W Hewitt, Andrew Boyle, Richard Harvey, Wayne A Morrison, David A Elliott, Gregory J Dusting, Shiang Y Lim

Journal article  |  2015  |  STEM CELLS

FT011, a Novel Cardiorenal Protective Drug, Reduces Inflammation, Gliosis and Vascular Injury in Rats with Diabetic Retinopathy

Devy Deliyanti, Yuan Zhang, Fay Khong, David R Berka, David I Stapleton, Darren J Kelly, Jennifer L Wilkinson-Berka

Journal article  |  2015  |  PLOS ONE

Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension

Mark T Waddingham, Amanda J Edgley, Alberto Astolfo, Tadakatsu Inagaki, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Hirotsugu Tsuchimochi, Naoto Yagi, Darren J Kelly, Mikiyasu Shirai, James T Pearson

Journal article  |  2015  |  Cardiovascular Diabetology

Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy

Mark T Waddingham, Amanda J Edgley, Hirotsugu Tsuchimochi, Darren J Kelly, Mikiyasu Shirai, James T Pearson

Journal article  |  2015  |  World Journal of Diabetes

FT011, a novel cardiorenal protective drug, reduces inflammation, gliosis and vascular injury in rats with diabetic retinopathy

Jennifer L Wilkinson-Berka, Devy Deliyanti, Yuan Zhang, Fay Khong, David Berka, David Ian Stapelton, Darren Kelly

Conference Proceedings  |  2015  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Chloride channel ClC-5 binds to aspartyl aminopeptidase to regulate renal albumin endocytosis

Aven Lee, Craig Slattery, David J Nikolic-Paterson, Deanne H Hryciw, Sherwin Wilk, Elizabeth Wilk, Yuan Zhang, Valentina A Valova, Phillip J Robinson, Darren J Kelly, Philip Poronnik

Journal article  |  2015  |  American Journal of Physiology-Renal Physiology

Contribution of microRNA to pathological fibrosis in cardiorenal syndrome: impact of uremic toxins

Indrajeetsinh Rana, Andrew R Kompa, Joanna Skommer, Bing H Wang, Suree Lekawanvijit, Darren J Kelly, Henry Krum, Fadi J Charchar

Journal article  |  2015  |  Physiological Reports

Functional Interaction between Angiotensin II Receptor Type 1 and Chemokine (C-C Motif) Receptor 2 with Implications for Chronic Kidney Disease

Mohammed Akli Ayoub, Yuan Zhang, Robyn S Kelly, Heng B See, Elizabeth KM Johnstone, Elizabeth A McCall, James H Williams, Darren J Kelly, Kevin DG Pfleger

Journal article  |  2015  |  PLOS ONE

Elevated cannabinoid receptor 1 and G protein-coupled receptor 55 expression in proximal tubule cells and whole kidney exposed to diabetic conditions

Kayte A Jenkin, Andrew J McAinch, Yuan Zhang, Darren J Kelly, Deanne H Hryciw

Journal article  |  2015  |  Clinical and Experimental Pharmacology and Physiology

Combination therapy of mesenchymal stem cells and serelaxin effectively attenuates renal fibrosis in obstructive nephropathy

Brooke M Huuskes, Andrea F Wise, Alison J Cox, Ee X Lim, Natalie L Payne, Darren J Kelly, Chrishan S Samuel, Sharon D Ricardo

Journal article  |  2015  |  The FASEB Journal

Thioredoxin-Interacting Protein: A Potential Therapeutic Target for Treatment of Progressive Fibrosis in Diabetic Nephropathy

Christina YR Tan, Qi Weier, Yuan Zhang, Alison J Cox, Darren J Kelly, Robyn G Langham

Journal article  |  2015  |  Nephron

Impaired cardiac anti-oxidant activity in diabetes: human and correlative experimental studies

Kim A Connelly, Andrew Advani, Suzanne L Advani, Yuan Zhang, Young M Kim, Vanessa Shen, Kerri Thai, Darren J Kelly, Richard E Gilbert

Journal article  |  2014  |  Acta Diabetologica

High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy

Antoinette Bugyei-Twum, Andrew Advani, Suzanne L Advani, Yuan Zhang, Kerri Thai, Darren J Kelly, Kim A Connelly

Journal article  |  2014  |  Cardiovascular Diabetology

SDF-1/CXCR4 Signaling Preserves Microvascular Integrity and Renal Function in Chronic Kidney Disease

Li-Hao Chen, Suzanne L Advani, Kerri Thai, M Golam Kabir, Manish M Sood, Ian W Gibson, Darren A Yuen, Kim A Connelly, Philip A Marsden, Darren J Kelly, Richard E Gilbert, Andrew Advani

Journal article  |  2014  |  PLoS ONE

3 ',4 '-Bis-difluoromethoxycinnamoylanthranilate (FT061): An orally-active antifibrotic agent that reduces albuminuria in a rat model of progressive diabetic nephropathy

Spencer J Williams, Steven C Zammit, Alison J Cox, David M Shackleford, Julia Morizzi, Yuan Zhang, Andrew K Powell, Richard E Gilbert, Henry Krum, Darren J Kelly

Journal article  |  2013  |  Bioorganic and Medicinal Chemistry Letters

The Uremic Toxin Adsorbent AST-120 Abrogates Cardiorenal Injury Following Myocardial Infarction

Suree Lekawanvijit, Sirinart Kumfu, Bing H Wang, Minako Manabe, Fuyuhiko Nishijima, Darren J Kelly, Henry Krum, Andrew R Kompa

Journal article  |  2013  |  PLoS One

Particle loss and volume change on dissolution: Experimental results and analysis of particle size and amount effects

J McDougall, D Kelly, D Barreto

Journal article  |  2013  |  Acta Geotechnica

Obesity Is Associated with Lower Coronary Microvascular Density

Duncan J Campbell, Jithendra B Somaratne, David L Prior, Michael Yii, James F Kenny, Andrew E Newcomb, Darren J Kelly, Mary Jane Black

Journal article  |  2013  |  PLoS One

Subtotal nephrectomy accelerates pathological cardiac remodeling post-myocardial infarction: Implications for cardiorenal syndrome

Shan Liu, Andrew R Kompa, Sirinart Kumfu, Fuyuhiko Nishijima, Darren J Kelly, Henry Krum, Bing H Wang

Journal article  |  2013  |  International Journal of Cardiology

A new anti-fibrotic drug attenuates cardiac remodeling and systolic dysfunction following experimental myocardial infarction

Yuan Zhang, Maros Elsik, Amanda J Edgley, Alison J Cox, Andrew R Kompa, Bing Wang, Christina Yan Ru Tan, Fay L Khong, David I Stapleton, Steven Zammit, Spencer J Williams, Richard E Gilbert, Henry Krum, Darren J Kelly

Journal article  |  2013  |  International Journal of Cardiology

The Anti-fibrotic Hormone Relaxin is not Reno-protective, Despite Being Active, in an Experimental Model of Type 1 Diabetes

Su Ee Wong, Chrishan S Samuel, Darren J Kelly, Yuan Zhang, Gavin J Becker, Tim D Hewitson

Journal article  |  2013  |  Protein and Peptide Letters

Atrial Arrhythmia in Ageing Spontaneously Hypertensive Rats: Unraveling the Substrate in Hypertension and Ageing

Dennis H Lau, Nicholas J Shipp, Darren J Kelly, Shivshankar Thanigaimani, Melissa Neo, Pawel Kuklik, Han S Lim, Yuan Zhang, Karen Drury, Christopher X Wong, Nicholas H Chia, Anthony G Brooks, Hany Dimitri, David A Saint, Lindsay Brown, Prashanthan Sanders

Journal article  |  2013  |  PLoS One

Reduced microvascular density in non-ischemic myocardium of patients with recent non-ST-segment-elevation myocardial infarction

Duncan J Campbell, Jithendra B Somaratne, Alicia J Jenkins, David L Prior, Michael Yii, James F Kenny, Andrew E Newcomb, Darren J Kelly, Mary Jane Black

Journal article  |  2013  |  International Journal of Cardiology

Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation

James T Pearson, Mathew J Jenkins, Amanda J Edgley, Takashi Sonobe, Mandar Joshi, Mark T Waddingham, Yutaka Fujii, Daryl O Schwenke, Hirotsugu Tsuchimochi, Misa Yoshimoto, Keiji Umetani, Darren J Kelly, Mikiyasu Shirai

Journal article  |  2013  |  Cardiovascular Diabetology

Soluble epoxide hydrolase inhibition exerts beneficial anti-remodeling actions post-myocardial infarction

Andrew R Kompa, Bing H Wang, Guoying Xu, Yuan Zhang, Pei-Yu Ho, Stephen Eisennagel, Reema K Thalji, Joseph P Marino, Darren J Kelly, David J Behm, Henry Krum

Journal article  |  2013  |  International Journal of Cardiology

Role of the EGF receptor in PPAR gamma-mediated sodium and water transport in human proximal tubule cells

S Saad, J Zhang, R Yong, D Yaghobian, MG Wong, DJ Kelly, XM Chen, CA Pollock

Journal article  |  2013  |  Diabetologia

Combination Angiotensin Converting Enzyme and Direct Renin Inhibition in Heart Failure following Experimental Myocardial Infarction

KA Connelly, A Advani, S Advani, Y Zhang, K Thai, S Thomas, H Krum, DJ Kelly, RE Gilbert

Journal article  |  2013  |  Cardiovascular Therapeutics

Myosin Heads Are Displaced from Actin Filaments in the In Situ Beating Rat Heart in Early Diabetes

Mathew J Jenkins, James T Pearson, Daryl O Schwenke, Amanda J Edgley, Takashi Sonobe, Yutaka Fujii, Hatsue Ishibashi-Ueda, Darren J Kelly, Naoto Yagi, Mikiyasu Shirai

Journal article  |  2013  |  Biophysical Journal

Attenuation of Armanni-Ebstein lesions in a rat model of diabetes by a new anti-fibrotic, anti-inflammatory agent, FT011

X Lau, Y Zhang, DJ Kelly, DI Stapleton

Journal article  |  2013  |  Diabetologia

Early and Delayed Tranilast Treatment Reduces Pathological Fibrosis Following Myocardial Infarction

Fiona See, Masataka Watanabe, Andrew R Kompa, Bing H Wang, Andrew J Boyle, Darren J Kelly, Richard E Gilbert, Henry Krum

Journal article  |  2013  |  Heart, Lung and Circulation

Role of the eNOS-NO System in Regulating the Antiproteinuric Effects of VEGF Receptor 2 Inhibition in Diabetes

Andrew Advani, Kim A Connelly, Suzanne L Advani, Kerri Thai, Yuan Zhang, Darren J Kelly, Richard E Gilbert

Journal article  |  2013  |  BioMed Research International

Urotensin II and the kidney

Robyn G Langham, Darren J Kelly

Journal article  |  2013  |  Current Opinion in Nephrology and Hypertension

Cannabinoid Receptor 2 Expression in Human Proximal Tubule Cells is Regulated by Albumin Independent of ERK1/2 Signaling

Kayte A Jenkin, Andrew J McAinch, Jessica F Briffa, Yuan Zhang, Darren J Kelly, Carol A Pollock, Philip Poronnik, Deanne H Hryciw

Journal article  |  2013  |  Cellular Physiology and Biochemistry

Obesity results in progressive atrial structural and electrical remodeling: Implications for atrial fibrillation

Hany S Abed, Chrishan S Samuel, Dennis H Lau, Darren J Kelly, Simon G Royce, Muayad Alasady, Rajiv Mahajan, Pawel Kuklik, Yuan Zhang, Anthony G Brooks, Adam J Nelson, Stephen G Worthley, Walter P Abhayaratna, Jonathan M Kalman, Gary A Wittert, Prashanthan Sanders

Journal article  |  2013  |  Heart Rhythm

Diastolic Dysfunction of Aging Is Independent of Myocardial Structure but Associated with Plasma Advanced Glycation End-Product Levels

Duncan J Campbell, Jithendra B Somaratne, Alicia J Jenkins, David L Prior, Michael Yii, James F Kenny, Andrew E Newcomb, Casper G Schalkwijk, Mary Jane Black, Darren J Kelly

Journal article  |  2012  |  PLoS One

Cardiorenal Syndrome The Emerging Role of Protein-Bound Uremic Toxins

Suree Lekawanvijit, Andrew R Kompa, Bing H Wang, Darren J Kelly, Henry Krum

Journal article  |  2012  |  Circulation Research

eNOS Deficiency Predisposes Podocytes to Injury in Diabetes

Darren A Yuen, Bailey E Stead, Yanling Zhang, Kathryn E White, M Golam Kabir, Kerri Thai, Suzanne L Advani, Kim A Connelly, Tomoko Takano, Lei Zhu, Alison J Cox, Darren J Kelly, Ian W Gibson, Takamune Takahashi, Raymond C Harris, Andrew Advani

Journal article  |  2012  |  Journal of the American Society of Nephrology

A Purpose-Synthesised Anti-Fibrotic Agent Attenuates Experimental Kidney Diseases in the Rat

Richard E Gilbert, Yuan Zhang, Spencer J Williams, Steven C Zammit, David I Stapleton, Alison J Cox, Henry Krum, Robyn Langham, Darren J Kelly

Journal article  |  2012  |  PLoS One

Cardiorenal syndrome: Pathophysiology, preclinical models, management and potential role of uraemic toxins

Shan Liu, Suree Lekawanvijit, Andrew R Kompa, Bing H Wang, Darren J Kelly, Henry Krum

Journal article  |  2012  |  Clinical and Experimental Pharmacology and Physiology

Subtotal nephrectomy accelerates pathological cardiac remodeling post myocardial infarction: implications for the cardiorenal syndrome

S Liu, A Kompa, D Kelly, H Krum, B Wang

Conference Proceedings  |  2012  |  EUROPEAN HEART JOURNAL

FT23, an orally active antifibrotic compound, attenuates structural and functional abnormalities in an experimental model of diabetic cardiomyopathy

Sih Min Tan, Yuan Zhang, Bing Wang, Christina YR Tan, Steven C Zammit, Spencer J Williams, Henry Krum, Darren J Kelly

Journal article  |  2012  |  Clinical and Experimental Pharmacology and Physiology

Chronic Kidney Disease-Induced Cardiac Fibrosis Is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uremic Toxin, Indoxyl Sulfate

Suree Lekawanvijit, Andrew R Kompa, Minako Manabe, Bing H Wang, Robyn G Langham, Fuyuhiko Nishijima, Darren J Kelly, Henry Krum

Journal article  |  2012  |  PLoS One

Myocardial infarction impairs renal function, induces renal interstitial fibrosis, and increases renal KIM-1 expression: implications for cardiorenal syndrome

Suree Lekawanvijit, Andrew R Kompa, Yuan Zhang, Bing H Wang, Darren J Kelly, Henry Krum

Journal article  |  2012  |  American Journal of Physiology - Heart and Circulatory Physiology

FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy

Yuan Zhang, Amanda J Edgley, Alison J Cox, Andrew K Powell, Bing Wang, Andrew R Kompa, David I Stapleton, Steven C Zammit, Spencer J Williams, Henry Krum, Richard E Gilbert, Darren J Kelly

Journal article  |  2012  |  European Journal of Heart Failure

Dynamic Synchrotron Imaging of Diabetic Rat Coronary Microcirculation In Vivo

Mathew J Jenkins, Amanda J Edgley, Takashi Sonobe, Keiji Umetani, Daryl O Schwenke, Yutaka Fujii, Russell D Brown, Darren J Kelly, Mikiyasu Shirai, James T Pearson

Journal article  |  2012  |  Arteriosclerosis Thrombosis and Vascular Biology

Targeting Fibrosis for the Treatment of Heart Failure: A Role for Transforming Growth Factor-beta

Amanda J Edgley, Henry Krum, Darren J Kelly

Journal article  |  2012  |  Cardiovascular Therapeutics

Therapeutic effects of human STRO-3-selected mesenchymal precursor cells and their soluble factors in experimental myocardial ischemia

Fiona See, Tetsunori Seki, Peter J Psaltis, Hugo P Sondermeijer, Stan Gronthos, Andrew CW Zannettino, Klaas M Govaert, Michael D Schuster, Paul A Kurlansky, Darren J Kelly, Henry Krum, Silviu Itescu

Journal article  |  2011  |  Journal of Cellular and Molecular Medicine

Impact of type 2 diabetes and the metabolic syndrome on myocardial structure and microvasculature of men with coronary artery disease

Duncan J Campbell, Jithendra B Somaratne, Alicia J Jenkins, David L Prior, Michael Yii, James F Kenny, Andrew E Newcomb, Casper G Schalkwijk, Mary J Black, Darren J Kelly

Journal article  |  2011  |  Cardiovascular Diabetology

Protein kinase C beta inhibition ameliorates experimental mesangial proliferative glomerulonephritis

Hirobumi Tokuyama, Sandra Kim, Yuan Zhang, Robyn G Langham, Alison J Cox, Renae M Gow, Darren J Kelly, Richard E Gilbert

Journal article  |  2011  |  Nephrology

Aliskiren increases bradykinin and tissue kallikrein mRNA levels in the heart

Duncan J Campbell, Yuan Zhang, Darren J Kelly, Richard E Gilbert, Davis J McCarthy, Wei Shi, Gordon K Smyth

Journal article  |  2011  |  Clinical and Experimental Pharmacology and Physiology

Inhibition of the epidermal growth factor receptor preserves podocytes and attenuates albuminuria in experimental diabetic nephropathy

Andrew Advani, Kathryn J Wiggins, Alison J Cox, Yuan Zhang, Richard E Gilbert, Darren J Kelly

Journal article  |  2011  |  Nephrology

3 ',4 '-Dihydroxyflavonol Antioxidant Attenuates Diastolic Dysfunction and Cardiac Remodeling in Streptozotocin-Induced Diabetic m(Ren2)27 Rats

Fay Lin Khong, Yuan Zhang, Amanda J Edgley, Weier Qi, Kim A Connelly, Owen L Woodman, Henry Krum, Darren J Kelly

Journal article  |  2011  |  PLoS One

The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy

Kim A Connelly, Andrew Advani, Sandra Kim, Suzanne L Advani, Michael Zhang, Kathryn E White, Young M Kim, Colleen Parker, Kerri Thai, Henry Krum, Darren J Kelly, Richard E Gilbert

Journal article  |  2011  |  Journal of Hypertension

Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism

Andrew Advani, Qingling Huang, Kerri Thai, Suzanne L Advani, Kathryn E White, Darren J Kelly, Darren A Yuen, Kim A Connelly, Philip A Marsden, Richard E Gilbert

Journal article  |  2011  |  American Journal of Pathology

Atrial protective effects of n-3 polyunsaturated fatty acids: A long-term study in ovine chronic heart failure

Dennis H Lau, Peter J Psaltis, Angelo Carbone, Darren J Kelly, Lorraine Mackenzie, Michael Worthington, Robert G Metcalf, Pawel Kuklik, Adam J Nelson, Yuan Zhang, Christopher X Wong, Anthony G Brooks, David A Saint, Michael J James, James Edwards, Glenn D Young, Stephen G Worthley, Prashanthan Sanders

Journal article  |  2011  |  Heart Rhythm

The roles of Kruppel-like factor 6 and peroxisome proliferator-activated receptor-gamma in the regulation of macrophage inflammatory protein-3 alpha at early onset of diabetes

Weier Qi, John Holian, Christina YR Tan, Darren J Kelly, Xin-Ming Chen, Carol A Pollock

Journal article  |  2011  |  International Journal of Biochemistry and Cell Biology

Differences in Myocardial Structure and Coronary Microvasculature Between Men and Women With Coronary Artery Disease

Duncan J Campbell, Jithendra B Somaratne, Alicia J Jenkins, David L Prior, Michael Yii, James F Kenny, Andrew E Newcomb, Darren J Kelly, Mary Jane Black

Journal article  |  2011  |  Hypertension

Ramipril retards development of aortic valve stenosis in a rabbit model: mechanistic considerations

Doan TM Ngo, Irene Stafford, Aaron L Sverdlov, Weier Qi, Ronald D Wuttke, Yuan Zhang, Darren J Kelly, Helen Weedon, Malcolm D Smith, Jennifer A Kennedy, John D Horowitz

Journal article  |  2011  |  British Journal of Pharmacology

Atrial Remodeling in an Ovine Model of Anthracycline-Induced Nonischemic Cardiomyopathy: Remodeling of the Same Sort

Dennis H Lau, Peter J Psaltis, Lorraine Mackenzie, Darren J Kelly, Angelo Carbone, Michael Worthington, Adam J Nelson, Yuan Zhang, Pawel Kuklik, Christopher X Wong, James Edwards, David A Saint, Stephen G Worthley, Prashanthan Sanders

Journal article  |  2011  |  Journal of Cardiovascular Electrophysiology

Predictors of Atrial Fibrosis in an Ovine Model of Obesity

HS Abed, AJ Nelson, SG Worthley, GA Wittert, P Sanders, D Kelly

Journal article  |  2011  |  Journal of Arrhythmia

Tranilast attenuates the up-regulation of thioredoxin-interacting protein and oxidative stress in an experimental model of diabetic nephropathy

Sih Min Tan, Yuan Zhang, Alison J Cox, Darren J Kelly, Weier Qi

Journal article  |  2011  |  Nephrology, Dialysis, Transplantation

Obesity and Atrial Fibrillation: A Chronic Ovine Study

H Abed, D Lau, D Kelly, A Nelson, G Wittert, P Sanders

Journal article  |  2011  |  Journal of Arrhythmia

Effect of Atorvastatin on Cardiac Remodelling and Mortality in Rats Following Hyperglycemia and Myocardial Infarction

Jennifer H Martin, Kim A Connelly, Andrew Boyle, Andrew Kompa, Yuan Zhang, Darren Kelly, Richard E Gilbert, Henry Krum

Journal article  |  2010  |  International Journal of Cardiology

Hypertension and atrial fibrillation: Evidence of progressive atrial remodeling with electrostructural correlate in a conscious chronically instrumented ovine model

Dennis H Lau, Lorraine Mackenzie, Darren J Kelly, Peter J Psaltis, Anthony G Brooks, Michael Worthington, Arumuga Rajendram, Douglas R Kelly, Yuan Zhang, Pawel Kuklik, Adam J Nelson, Christopher X Wong, Stephen G Worthley, Mohan Rao, Randall J Faull, James Edwards, David A Saint, Prashanthan Sanders

Journal article  |  2010  |  Heart Rhythm

Chronic urotensin II receptor antagonist treatment does not alter hypertrophy or fibrosis in a rat model of pressure-overload hypertrophy

Andrew R Kompa, Bing H Wang, Arintaya Phrommintikul, Pei Y Ho, Darren J Kelly, David J Behm, Stephen A Douglas, Henry Krum

Journal article  |  2010  |  Peptides

Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes?

Suree Lekawanvijit, Anastasia Adrahtas, Darren J Kelly, Andrew R Kompa, Bing H Wang, Henry Krum

Journal article  |  2010  |  European Heart Journal

Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction

Sih Min Tan, Yuan Zhang, Kim A Connelly, Richard E Gilbert, Darren J Kelly

Journal article  |  2010  |  American Journal of Physiology - Heart and Circulatory Physiology

Microglia activation in the hypothalamic PVN following myocardial infarction

Indrajeetsinh Rana, Martin Stebbing, Andrew Kompa, Darren J Kelly, Henry Krum, Emilio Badoer

Journal article  |  2010  |  Brain Research

Characterization of cardiac remodeling in a large animal "one-kidney, one-clip" hypertensive model

Dennis H Lau, Lorraine Mackenzie, Arumuga Rajendram, Peter J Psaltis, Douglas R Kelly, Peter Spyropoulos, Yuan Zhang, Santosh A Olakkengil, Christine H Russell, Anthony G Brooks, Randall J Faull, David A Saint, Darren J Kelly, M Mohan Rao, Stephen G Worthley, Prashanthan Sanders

Journal article  |  2010  |  Blood Pressure

Increased tissue kallikrein levels in type 2 diabetes

DJ Campbell, A Kladis, Y Zhang, AJ Jenkins, DL Prior, M Yii, JF Kenny, MJ Black, DJ Kelly

Journal article  |  2010  |  Diabetologia

Culture-Modified Bone Marrow Cells Attenuate Cardiac and Renal Injury in a Chronic Kidney Disease Rat Model via a Novel Antifibrotic Mechanism

Darren A Yuen, Kim A Connelly, Andrew Advani, Christine Liao, Michael A Kuliszewski, Judy Trogadis, Kerri Thai, Suzanne L Advani, Yuan Zhang, Darren J Kelly, Howard Leong-Poi, Armand Keating, Philip A Marsden, Duncan J Stewart, Richard E Gilbert

Journal article  |  2010  |  PLoS One

Short-term hypertension is associated with the development of atrial fibrillation substrate: A study in an ovine hypertensive model

Dennis H Lau, Lorraine Mackenzie, Darren J Kelly, Peter J Psaltis, Michael Worthington, Arumuga Rajendram, Douglas R Kelly, Adam J Nelson, Yuan Zhang, Pawel Kuklik, Anthony G Brooks, Stephen G Worthley, Randall J Faull, Mohan Rao, James Edwards, David A Saint, Prashanthan Sanders

Journal article  |  2010  |  Heart Rhythm

Laser-Capture Microdissection and Pressure Catapulting for the Analysis of Gene Expression in the Renal Glomerulus

Amanda J Edgley, Renae M Gow, Darren J Kelly

Book Chapter  |  2010  |  Methods in Molecular Biology

(Hetero)aryl compounds as antifibrotic agents and their preparation, pharmaceutical compositions and use in the treatment of fibrosis

SJ Williams, S Zammit, DJ Kelly, W James

Patent  |  2010

Evaluation and optimization of antifibrotic activity of cinnamoyl anthranilates

Steven C Zammit, Alison J Cox, Renae M Gow, Yuan Zhang, Richard E Gilbert, Henry Krum, Darren J Kelly, Spencer J Williams

Journal article  |  2009  |  Bioorganic and Medicinal Chemistry Letters

Intensity of renal support in critically ill patients with acute kidney injury (New England Journal of Medicine (2008) 359, (7-20))

PM Palevsky, JH Zhang, TZ O'Connor, GM Chertow, ST Crowley, D Choudhury, K Finkel, JA Kellum, E Paganini, RMH Schein, MW Smith, KM Swanson, BT Thompson, A Vijayan, S Watnick, RA Star, P Peduzzi, E Young, R Fissel, W Fissel, et al.

Journal article  |  2009  |  New England Journal of Medicine

Transcription Factors Kruppel-Like Factor 6 and Peroxisome Proliferator-Activated Receptor-gamma Mediate High Glucose-Induced Thioredoxin-Interacting Protein

Weier Qi, Xinming Chen, John Holian, Christina YR Tan, Darren J Kelly, Carol A Pollock

Journal article  |  2009  |  American Journal of Pathology

EGFR-PLC gamma 1 signaling mediates high glucose-induced PKC beta 1-Akt activation and collagen I upregulation in mesangial cells

D Wu, F Peng, B Zhang, AJ Ingram, DJ Kelly, RE Gilbert, B Gao, S Kumar, JC Krepinsky

Journal article  |  2009  |  American Journal of Physiology: Renal Physiology

Role of statins in diabetes complications.

Jennifer H Martin, Salvatore Mangiafico, Darren J Kelly

Journal article  |  2009  |  Current Diabetes Reviews

Diabetes is one of the major causes of morbidity and mortality in the Western world and it currently affects 35 million people in ..

The (Pro) Renin Receptor Site-Specific and Functional Linkage to the Vacuolar H -ATPase in the Kidney

Andrew Advani, Darren J Kelly, Alison J Cox, Kathryn E White, Suzanne L Advani, Kerri Thai, Kim A Connelly, Darren Yuen, Judy Trogadis, Andrew M Herzenberg, Michael A Kuliszewski, Howard Leong-Poi, Richard E Gilbert

Journal article  |  2009  |  Hypertension

Aliskiren: a novel renoprotective agent or simply an alternative to ACE inhibitors?

Kathryn J Wiggins, Darren J Kelly

Journal article  |  2009  |  Kidney International

Protein kinase C-beta inhibition attenuates the progression of nephropathy in non-diabetic kidney disease

Darren J Kelly, Amanda J Edgley, Yuan Zhang, Kerri Thai, Sih Min Tan, Alison J Cox, Andrew Advani, Kim A Connelly, Catharine I Whiteside, Richard E Gilbert

Journal article  |  2009  |  Nephrology, Dialysis, Transplantation

Inhibition of Protein Kinase C-beta by Ruboxistaurin Preserves Cardiac Function and Reduces Extracellular Matrix Production in Diabetic Cardiomyopathy

Kim A Connelly, Darren J Kelly, Yuan Zhang, David L Prior, Andrew Advani, Alison J Cox, Kerri Thai, Henry Krum, Richard E Gilbert

Journal article  |  2009  |  Circulation. Heart Failure

PKC-beta 1 Mediates Glucose-Induced Akt Activation and TGF-beta 1 Upregulation in Mesangial Cells

Dongcheng Wu, Fangfang Peng, Baifang Zhang, Alistair J Ingram, Darren J Kelly, Richard E Gilbert, Bo Gao, Joan C Krepinsky

Journal article  |  2009  |  Journal of the American Society of Nephrology

High glucose induced endothelial cell growth inhibition is associated with an increase in TGF beta(1) secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway

A Mather, XM Chen, S McGinn, MJ Field, S Sumual, S Mangiafico, Y Zhang, DJ Kelly, CA Pollock

Journal article  |  2009  |  International Journal of Biochemistry and Cell Biology

BK virus RNA can be detected in archival renal transplant biopsies using the reverse trancription polymerase chain reaction

Kathryn J Wiggins, Renae M Gow, John Kanellis, Prue Hill, Darren J Kelly, Alison Skene, David J Goodman, Robyn G Langham

Journal article  |  2009  |  Nephrology, Dialysis, Transplantation

Halogenated cinnamoylbenzamide analogs of anti-fibrotic agents and their preparation

DJ Kelly, SJ Williams, S Zammit

Patent  |  2009

Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenic Ren-2 rats

Kathryn J Wiggins, Victoria Tiauw, Yuan Zhang, Richard E Gilbert, Robyn G Langham, Darren J Kelly

Journal article  |  2008  |  Nephrology

In vivo visualization of albumin degradation in the proximal tubule

Craig Slattery, Aven Lee, Yuan Zhang, Darren J Kelly, Peter Thorn, David J Nikolic-Paterson, Greg H Tesch, Philip Poronnik

Journal article  |  2008  |  Kidney International

Role of Kruppel-like factor 6 in transforming growth factor-beta 1-induced epithelial-mesenchymal transition of proximal tubule cells

John Holian, Weier Qi, Darren J Kelly, Yuan Zhang, Ellein Mreich, Carol A Pollock, Xin-Ming Chen

Journal article  |  2008  |  American Journal of Physiology: Renal Physiology

Vitamin D(2) supplementation induces the development of aortic stenosis in rabbits: Interactions with endothelial function and thioredoxin-interacting protein

Doan TM Ngo, Irene Stafford, Darren J Kelly, Aaron L Sverdlov, Ronald D Wuttke, Helen Weedon, Angus K Nightingale, Anke C Rosenkranz, Malcolm D Smith, Yuliy Y Chirkov, Jennifer A Kennedy, John D Horowitz

Journal article  |  2008  |  European Journal of Pharmacology

Intensity of renal support in critically ill patients with acute kidney injury.

undefined VA/NIH Acute Renal Failure Trial Network, Paul M Palevsky, Jane Hongyuan Zhang, Theresa Z O'Connor, Glenn M Chertow, Susan T Crowley, Devasmita Choudhury, Kevin Finkel, John A Kellum, Emil Paganini, Roland MH Schein, Mark W Smith, Kathleen M Swanson, B Taylor Thompson, Anitha Vijayan, Suzanne Watnick, Robert A Star, Peter Peduzzi

Journal article  |  2008  |  New England Journal of Medicine

BACKGROUND: The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversia..

Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy

Chrishan S Samuel, Tim D Hewitson, Yuan Zhang, Darren J Kelly

Journal article  |  2008  |  Endocrinology

Effects of a Rho kinase inhibitor on pressure overload induced cardiac hypertrophy and associated diastolic dysfunction

Arintaya Phrommintikul, Lavinia Tran, Andrew Kompa, Bing Wang, Anastasia Adrahtas, Danielle Cantwell, Darren J Kelly, Henry Krum

Journal article  |  2008  |  American Journal of Physiology - Heart and Circulatory Physiology

Increased renal gene transcription of protein kinase C-beta in human diabetic nephropathy: relationship to long-term glycaemic control

RG Langham, DJ Kelly, RM Gow, Y Zhang, AJ Cox, W Qi, K Thai, CA Pollock, PK Christensen, H-H Parving, RE Gilbert

Journal article  |  2008  |  Diabetologia

Tranilast ameliorates experimental mesangial proliferative glomerulonephritis

Hirobumi Tokuyama, Darren J Kelly, Alison Cox, Yuan Zhang, Kerri Thai, David J Nikolic-Paterson, Richard E Gilbert

Journal article  |  2008  |  Nephron Experimental Nephrology

Preparation of cinnamoyl anthranilates and analogs thereof with antifibrotic activity

S ZAMMIT, R GILBERT, H KRUM, S WILLIAMS, D KELLY

Patent  |  2008

Functional, structural and molecular aspects of diastolic heart failure in the diabetic (mRen-2)27 rat

KA Connelly, DJ Kelly, Y Zhang, DL Prior, J Martin, AJ Cox, K Thai, MP Feneley, J Tsoporis, KE White, H Krum, RE Gilbert

Journal article  |  2007  |  Cardiovascular Research

Tranilast attenuates diastolic dysfunction and structural injury in experimental diabetic cardiomyopathy

Darren J Kelly, Yuan Zhang, Kim Connelly, Alison J Cox, Jennifer Martin, Henry Krum, Richard E Gilbert

Journal article  |  2007  |  American Journal of Physiology - Heart and Circulatory Physiology

High glucose induces macrophage inflammatory protein-3 alpha in renal proximal tubule cells via a transforming growth factor-beta 1 dependent mechanism

Weier Qi, Xinming Chen, Yuan Zhang, John Holian, Ellein Mreich, Richard E Gilbert, Darren J Kelly, Carol A Pollock

Journal article  |  2007  |  Nephrology, Dialysis, Transplantation

Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats

DJ Kelly, Y Zhang, G Moe, G Naik, RE Gilbert

Journal article  |  2007  |  Diabetologia

Clinically relevant models of diabetic cardiac complications

Kim Connelly, Darren Kelly, Richard Gilbert

Journal article  |  2007  |  Circulation Research

Role of VEGF in maintaining renal structure and function under normotensive and hypertensive conditions

Andrew Advani, Darren J Kelly, Suzanne L Advani, Alison J Cox, Kerri Thai, Yuan Zhang, Kathryn E White, Renae M Gow, Sally M Marshall, Brent M Steer, Philip A Marsden, P Elizabeth Rakoczy, Richard E Gilbert

Journal article  |  2007  |  Proceedings of the National Academy of Sciences of the United States of America

High glucose-induced thioredoxin-interacting protein in renal proximal tubule cells is independent of transforming growth factor-beta 1

Weier Qi, Xinming Chen, Richard E Gilbert, Yuan Zhang, Mark Waltham, Maria Sclhache, Darren J Kelly, Carol A Pollock

Journal article  |  2007  |  American Journal of Pathology

Effects on protein kinase C-beta inhibition on glomerular vascular endothelial growth factor expression and endothelial cells in advanced experimental diabetic nephropathy

Darren J Kelly, Danielle Buck, Alison J Cox, Yuan Zhang, Richard E Gilbert

Journal article  |  2007  |  American Journal of Physiology: Renal Physiology

Advanced glycation end products decrease mesangial cell MMP-7: A role in matrix accumulation in diabetic nephropathy?

SV McLennan, DJ Kelly, M Schache, M Waltham, V Dy, RG Langham, DK Yue, RE Gilbert

Journal article  |  2007  |  Kidney International

The differential regulation of Smad7 in kidney tubule cells by connective tissue growth factor and transforming growth factor-beta1

Weier Qi, Xinming Chen, Stephen Twigg, Yuan Zhang, Richard E Gilbert, Darren J Kelly, Carol A Pollock

Journal article  |  2007  |  Nephrology

Progressive diabetic nephropathy in the Ren-2 rat

Darren J Kelly, Jennifer L Wilkinson-Berka, Richard E Gilbert

Journal article  |  2007  |  American Journal of Physiology: Renal Physiology

Effect of ruboxistaurin on urina transforming growth factor-beta in patients with diabetic nephropathy and type 2 diabetes

Richard E Gilbert, Sandra A Kim, Katherine R Tuttle, George L Bakris, Robert D Toto, Janet B McGill, Douglas J Haney, Darren J Kelly, Pamela W Anderson

Journal article  |  2007  |  Diabetes Care

Diabetic nephropathy without the diabetes: If not hyperglycaemia, then what?

Robyn G Langham, Darren J Kelly

Journal article  |  2007  |  Nephrology

Macrophage infiltration and cellular proliferation in the non-ischemic kidney and heart following prolonged unilateral renal ischemia

Hirobumi Tokuyama, Darren J Kelly, Yuan Zhang, Renae M Gow, Richard E Gilbert

Journal article  |  2007  |  Nephron Physiology

Angiotensin II and the cardiac complications of diabetes mellitus

KA Connelly, AJ Boyle, DJ Kelly

Journal article  |  2007  |  Current Pharmaceutical Design

Transforming growth factor-beta in human diabetic nephropathy - Effects of ACE inhibition

Robyn G Langham, Darren J Kelly, Yuan Zhang, Daniel J Cordonnier, Nicole Pinel, Phillipe Zaoui, Richard E Gilbert

Journal article  |  2006  |  Diabetes Care

Glucose transporters in animal models of diabetes and hypertension - Reply

Suzanne Rogers, Darren J Kelly

Journal article  |  2006  |  American Journal of Physiology: Renal Physiology

Glucose transporters in animal models of diabetes and hypertension

Beatriz D'Agord Schaan, Ubiratan Fabres Machado, Suzanne Rogers, Darren J Kelly

Journal article  |  2006  |  American Journal of Physiology: Renal Physiology

Combination therapy with tranilast and angiotensin-converting enzyme inhibition provides additional renoprotection in the remnant kidney model.

DJ Kelly, Y Zhang, AJ Cox, RE Gilbert

Journal article  |  2006  |  Kidney International

Despite current therapy with agents that block the renin-angiotensin system, renal dysfunction continues to progress in a signific..

Load-sensitive measures may overestimate global systolic function in the presence of left ventricular hypertrophy: a comparison with load-insensitive measures

KA Connelly, DL Prior, DJ Kelly, MP Feneley, H Krum, RE Gilbert

Journal article  |  2006  |  American Journal of Physiology - Heart and Circulatory Physiology

SB-267268, a nonpeptidic antagonist of alpha(v)beta(3) and alpha(v)beta(5) integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity

JL Wilkinson-Berka, D Jones, G Taylor, K Jaworski, DJ Kelly, SB Ludbrook, RN Willette, SJ Kumar, RE Gilbert

Journal article  |  2006  |  Investigative Ophthalmology and Visual Science

Heart failure and nephropathy: Catastrophic and interrelated complications of diabetes

Richard E Gilbert, Kim Connelly, Darren J Kelly, Carol A Pollock, Henry Krum

Journal article  |  2006  |  Journal of the American Society of Nephrology

Mitogen activated protein kinase signaling in the kidney: Target for intervention?

MH De Borst, L Wassef, DJ Kelly, H Van Goor, G Navis

Journal article  |  2006  |  Signal Transduction

Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy

KC Linden, CL DeHaan, Y Zhang, S Glowacka, AJ Cox, DJ Kelly, S Rogers

Journal article  |  2006  |  American Journal of Physiology: Renal Physiology

Modulation of osteopontin in proteinuria-induced renal interstitial fibrosis

AB Kramer, SD Ricardo, DJ Kelly, F Waanders, H van Goor, G Navis

Journal article  |  2005  |  Journal of Pathology

High glucose transactivates the EGF receptor and up-regulates serum glucocorticoid kinase in the proximal tubule

S Saad, VA Stevens, L Wassef, P Poronnik, DJ Kelly, RE Gilbert, CA Pollock

Journal article  |  2005  |  Kidney International

Renin inhibition - New potential for an old therapeutic target

DJ Kelly, JL Wilkinson-Berka, RE Gilbert

Journal article  |  2005  |  Hypertension

Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction

A BOYLE, D KELLY, Y ZHANG, A COX, R GOW, K WAY, S ITESCU, H KRUM, R GILBERT

Journal article  |  2005  |  Journal of Molecular and Cellular Cardiology

Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction

AJ Boyle, DJ Kelly, Y Zhang, AJ Cox, RM Grow, K Way, S Itescu, H Krum, RE Gilbert

Journal article  |  2005  |  Journal of Molecular and Cellular Cardiology

Protein kinase C beta inhibition attenuates osteopontin expression, macrophage recruitment, and tubulointerstitial injury in advanced experimental diabetic nephropathy

DJ Kelly, A Chanty, RM Gow, Y Zhang, RE Gilbert

Journal article  |  2005  |  Journal of the American Society of Nephrology

Cells expressing the stem cell factor receptor, c-kit, contribute to neoangiogenesis in diabetes.

Darren J Kelly, Yuan Zhang, Renae M Gow, Silviu Itescu, Richard E Gilbert

Journal article  |  2005  |  Diabetes and Vascular Disease Research

While neoangiogenesis in diabetes is of greatest clinical significance in the retina, the pathological formation of new blood vess..

Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-beta

J Martin, DJ Kelly, SA Mifsud, Y Zhang, AJ Cox, F See, H Krum, J Wilkinson-Berka, RE Gibert

Journal article  |  2005  |  Cardiovascular Research

Neonatal calyceal dilation and renal fibrosis resulting from loss of Adamts-1 in mouse kidney is due to a developmental dysgenesis

L Mittaz, S Ricardo, G Martinez, I Kola, DJ Kelly, MH Little, PJ Hertzog, MA Pritchard

Journal article  |  2005  |  Nephrology, Dialysis, Transplantation

Increased expression of urotensin II and urotensin II receptor in human diabetic nephropathy

RG Langham, DJ Kelly, RM Gow, Y Zhang, JK Dowling, NM Thomson, RE Gilbert

Journal article  |  2004  |  American Journal of Kidney Diseases

Epidermal growth factor receptor inhibition attenuates early kidney enlargement in experimental diabetes

L Wassef, DJ Kelly, RE Gilbert

Journal article  |  2004  |  Kidney International

Tranilast attenuates structural and functional aspects of renal injury in the remnant kidney model

DJ Kelly, Y Zhang, R Gow, RE Gilbert

Journal article  |  2004  |  Journal of the American Society of Nephrology

Tranilast reduces mesenteric vascular collagen deposition and chymase-positive mast cells in experimental diabetes

SE Jones, RE Gilbert, DJ Kelly

Journal article  |  2004  |  Journal of Diabetes and its Complications

Platelet-derived growth factor receptor transactivation mediates the trophic effects of angiotensin II in vivo

DJ Kelly, AJ Cox, RM Gow, Y Zhang, BE Kemp, RE Gilbert

Journal article  |  2004  |  Hypertension

Plasmin is not protective in experimental renal interstitial fibrosis

KL Edgtton, RM Gow, DJ Kelly, P Carmeliet, AR Kitching

Journal article  |  2004  |  Kidney International

Expression of apoptosis-related factors in chronic cyclosporine nephrotoxicity after cyclosporine withdrawal

C Li, SW Lim, BK Sun, BS Choi, S Glowacka, AJ Cox, DJ Kelly, YS Kim, J Kim, BK Bang, CW Yang

Journal article  |  2004  |  Acta Pharmacologica Sinica

Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy

JL Wilkinson-Berka, S Babic, T de Gooyer, AW Stitt, K Jaworski, LGT Ong, DJ Kelly, RE Gilbert

Journal article  |  2004  |  American Journal of Pathology

Fas-induced apoptosis is a feature of progressive diabetic nephropathy in transgenic (mRen-2)27 rats: Attenuation with renin-angiotensin blockade

DJ Kelly, A Stein-Oakley, YA Zhang, L Wassef, J Maguire, T Koji, N Thomson, JL Wilkinson-Berka, RE Gilbert

Journal article  |  2004  |  Nephrology

Angiotensin II influences ovarian follicle development in the transgenic (mRen-2)27 and Sprague-Dawley rat

TE de Gooyer, SL Skinner, ME Wlodek, DJ Kelly, JL Wilkinson-Berka

Journal article  |  2004  |  Journal of Endocrinology

Vasoactive renal factors and the progression of diabetic nephropathy

L Wassef, RG Langham, DJ Kelly

Journal article  |  2004  |  Current Pharmaceutical Design

Angiotensin II-induced proteinuria and expression of the podocyte slit pore membrane protein, nephrin

RG Langham, DJ Kelly, AJ Cox, RM Gow, H Holthofer, RE Gilbert

Journal article  |  2004  |  Nephrology, Dialysis, Transplantation

Drug therapy for the cardiac complications of diabetes

K Connelly, DJ Kelly, R Langham, H Krum, RE Gilbert

Journal article  |  2004  |  Drug Discovery Today: Therapeutic Strategies

Does vascular endothelial growth factor (VEGF) play a role in the pathogenesis of minimal change disease?

G Boner, AJ Cox, DJ Kelly, A Tobar, J Bernheim, RG Langham, ME Cooper, RE Gilbert

Journal article  |  2003  |  Nephrology, Dialysis, Transplantation

Tranilast attenuates vascular hypertrophy, matrix accumulation and growth factor overexpression in experimental diabetes

F Bonnet, Z Cao, ME Cooper, AJ Cox, DJ Kelly, RE Gilbert

Journal article  |  2003  |  Diabetes & Metabolism

Mast cell infiltration and chemokine expression in progressive renal disease

SE Jones, DJ Kelly, AJ Cox, Y Zhang, RM Gow, RE Gilbert

Journal article  |  2003  |  Kidney International

Direct actions of urotensin II on the heart - Implications for cardiac fibrosis and hypertrophy

A Tzanidis, RD Hannan, WG Thomas, D Onan, DJ Autelitano, F See, DJ Kelly, RE Gilbert, H Krum

Journal article  |  2003  |  Circulation Research

The renin-angiotensin system and the long-term complications of diabetes: pathophysiological and therapeutic considerations

RE Gilbert, H Krum, J Wilkinson-Berka, DJ Kelly

Journal article  |  2003  |  Diabetic Medicine

Over-expression of platelet-derived growth factor in human diabetic nephropathy

RG Langham, DJ Kelly, J Maguire, JP Dowling, RE Gilbert, NM Thomson

Journal article  |  2003  |  Nephrology, Dialysis, Transplantation

Vascular endothelial growth factor expression and glomerular endothelial cell loss in the remnant kidney model

DJ Kelly, C Hepper, LL Wu, AJ Cox, RE Gilbert

Journal article  |  2003  |  Nephrology, Dialysis, Transplantation

COX-2 inhibition and retinal angiogenesis in a mouse model of retinopathy of prematurity

JL Wilkinson-Berka, NS Alousis, DJ Kelly, RE Gilbert

Journal article  |  2003  |  Investigative Ophthalmology and Visual Science

Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension

DJ Kelly, YA Zhang, C Hepper, RM Gow, K Jaworski, BE Kemp, JL Wilkinson-Berka, RE Gilbert

Journal article  |  2003  |  Diabetes

The renin-angiotensin system influences ocular endothelial cell proliferation in diabetes - Transgenic and interventional studies

CJ Moravski, SL Skinner, AJ Stubbs, S Sarlos, DJ Kelly, ME Cooper, RE Gilbert, JL Wilkinson-Berka

Journal article  |  2003  |  American Journal of Pathology

Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy.

Sally Mifsud, Darren J Kelly, Weier Qi, Yuan Zhang, Carol A Pollock, Jennifer L Wilkinson-Berka, Richard E Gilbert

Journal article  |  2003  |  Nephron Physiology

BACKGROUND/AIMS: Tubulointerstitial pathology with the accumulation of extracellular matrix are pathological hallmarks of diabetic..

ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat

JL Wilkinson-Berka, DJ Kelly, SM Koerner, K Jaworski, B Davis, V Thallas, ME Cooper

Journal article  |  2002  |  Diabetes

Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition

RG Langham, DJ Kelly, AJ Cox, NM Thomson, H Holthofer, P Zaoui, N Pinel, DJ Cordonnier, RE Gilbert

Journal article  |  2002  |  Diabetologia

Expression during rat fetal development of GLUT12 - a member of the class III hexose transporter family

ML Macheda, DJ Kelly, JD Best, S Rogers

Journal article  |  2002  |  Anatomy and Embryology

Characterisation of a thymic renin-angiotensin system in the transgenic m(Ren-2)27 rat

JL Wilkinson-Berka, DJ Kelly, P Rong, DJ Campbell, SL Skinner

Journal article  |  2002  |  Molecular and Cellular Endocrinology

Expression of the slit-diaphragm protein, nephrin, in experimental diabetic nephropathy: differing effects of anti-proteinuric therapies

DJ Kelly, P Aaltonen, AJ Cox, JR Rumble, R Langham, S Panagiotopoulos, G Jerums, H Holthofer, RE Gilbert

Journal article  |  2002  |  Nephrology, Dialysis, Transplantation

Progression of tubulointerstitial injury by osteopontin-induced macrophage recruitment in advanced diabetic nephropathy of transgenic (mRen-2)27 rats

DJ Kelly, JL Wilkinson-Berka, SD Ricardo, AJ Cox, RE Gilbert

Journal article  |  2002  |  Nephrology, Dialysis, Transplantation

Effects of low-dose and early versus late perindopril treatment on the progression of severe diabetic nephropathy in (mREN-2)27 rats

SA Mifsud, SL Skinner, ME Cooper, DJ Kelly, JL Wilkinson-Berka

Journal article  |  2002  |  Journal of the American Society of Nephrology

Decreased matrix degradation in diabetic nephropathy: effects of ACE inhibition on the expression and activities of matrix metalloproteinases

SV McLennan, DJ Kelly, AJ Cox, Z Cao, JG Lyons, DK Yue, RE Gilbert

Journal article  |  2002  |  Diabetologia

Attenuation of tubular apoptosis by blockade of the renin-angiotensin system in diabetic Ren-2 rats

DJ Kelly, AJ Cox, M Tolcos, ME Cooper, JL Wilkinson-Berka, RE Gilbert

Journal article  |  2002  |  Kidney International

The interaction between the renin-angiotensin system and vascular endothelial growth factor in the pathogenesis of retinal neovascularization in diabetes

JL Wilkinson-Berka, DJ Kelly, RE Gilbert

Journal article  |  2001  |  Journal of Vascular Research

Aminoguanidine ameliorates overexpression of prosclerotic growth factors and collagen deposition in experimental diabetic nephropathy

DJ Kelly, RE Gilbert, AJ Cox, T Soulis, GT Jerums, ME Cooper

Journal article  |  2001  |  Journal of the American Society of Nephrology

Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis

G Paizis, RE Gilbert, ME Cooper, P Murthi, JM Schembri, LL Wu, JR Rumble, DJ Kelly, C Tikellis, A Cox, RA Smallwood, PW Angus

Journal article  |  2001  |  Journal of Hepatology

Renoprotective and anti-hypertensive effects of combined valsartan and perindopril in progressive diabetic nephropathy in the transgenic (mRen-2)27 rat

JL Wilkinson-Berka, NJ Gibbs, ME Cooper, SL Skinner, DJ Kelly

Journal article  |  2001  |  Nephrology, Dialysis, Transplantation

Podocyte foot process broadening in experimental diabetic nephropathy: amelioration with renin-angiotensin blockade

SA Mifsud, TJ Allen, JF Bertram, UL Hulthen, DJ Kelly, ME Cooper, JL Wilkinson-Berka, RE Gilbert

Journal article  |  2001  |  Diabetologia

PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis

RE Gilbert, DJ Kelly, T McKay, S Chadban, PA Hill, ME Cooper, RC Atkins, DJ Nikolic-Paterson

Journal article  |  2001  |  Kidney International

Novel approaches to the treatment of progressive renal disease.

RE Gilbert, DJ Kelly, RC Atkins

Journal article  |  2001  |  Current Opinion in Pharmacology

Diabetes and hypertension are major contributors to the increasing incidence of progressive renal disease. In addition to more pot..

Angiotensin and renal fibrosis

RE Gilbert, JL Wilkinson-Berka, DJ Kelly

Journal article  |  2001  |  Contributions to Nephrology

Nephropathy in type 2 diabetes: Current therapeutic strategies

RE Gilbert, DJ Kelly

Journal article  |  2001  |  Nephrology

Angiotensin-converting enzyme inhibition attenuates renal platelet-derived growth factor gene expression and cell proliferation in subtotal nephrectomy

K Jandeleit-Dahm, LL Wu, RJ Johnson, AJ Cox, DJ Kelly, ME Cooper, RE Gilbert

Journal article  |  2001  |  Nephrology

Experimental diabetic nephropathy: Is it relevant to the human disease

DJ Kelly, TJ Allen, ME Cooper

Journal article  |  2000  |  Nephrology

Retinal neovascularization is prevented by blockade of the renin-angiotensin system

CJ Moravski, DJ Kelly, ME Cooper, RE Gilbert, JF Bertram, S Shahinfar, SL Skinner, JL Wilkinson-Berka

Journal article  |  2000  |  Hypertension

Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosis.

Z Cao, DJ Kelly, A Cox, D Casley, JM Forbes, P Martinello, R Dean, RE Gilbert, ME Cooper

Journal article  |  2000  |  Kidney International

BACKGROUND: Angiotensin II (Ang II) is associated with cell proliferation and apoptosis. The role of the angiotensin type 2 recept..

Angiotensin converting enzyme inhibition reduces retinal overexpression of vascular endothelial growth factor and hyperpermeability in experimental diabetes

RE Gilbert, DJ Kelly, AJ Cox, JL Wilkinson-Berka, JR Rumble, T Osicka, S Panagiotopoulos, V Lee, EC Hendrich, G Jerums, ME Cooper

Journal article  |  2000  |  Diabetologia

Blockade of the renin-angiotensin and endothelin systems on progressive renal injury.

Z Cao, ME Cooper, LL Wu, AJ Cox, K Jandeleit-Dahm, DJ Kelly, RE Gilbert

Journal article  |  2000  |  Hypertension

The renin-angiotensin system (RAS) and endothelin system may both play a role in the pathogenesis of progressive renal injury. The..

Effects of endothelin or angiotensin II receptor blockade on diabetes in the transgenic (mRen-2)27 rat

DJ Kelly, SL Skinner, RE Gilbert, AJ Cox, ME Cooper, JL Wilkinson-Berka

Journal article  |  2000  |  Kidney International

Endothelin receptor antagonism ameliorates mast cell infiltration, vascular hypertrophy, and epidermal growth factor expression in experimental diabetes.

RE Gilbert, JR Rumble, Z Cao, AJ Cox, P van Eeden, TJ Allen, DJ Kelly, ME Cooper

Journal article  |  2000  |  Circulation Research

Vascular hypertrophy, a feature of experimental and human diabetes, has been implicated in the pathogenesis of the microvascular a..

SPARC gene expression is increased in diabetes-related mesenteric vascular hypertrophy.

K Jandeleit-Dahm, J Rumble, AJ Cox, DJ Kelly, M Dziadek, ME Cooper, RE Gilbert

Journal article  |  2000  |  Microvascular Research

The anti-adhesive extracellular matrix protein SPARC (secreted protein and rich in cysteine; osteonectin or BM-40) has been implic..

Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes

ME Cooper, D Vranes, S Youssef, SA Stacker, AJ Cox, B Rizkalla, DJ Casley, LA Bach, DJ Kelly, RE Gilbert

Journal article  |  1999  |  Diabetes

Pathological expression of renin and angiotensin II in the renal tubule after subtotal nephrectomy - Implications for the pathogenesis of tubulointerstitial fibrosis

RE Gilbert, LL Wu, DJ Kelly, A Cox, JL Wilkinson-Berka, CI Johnston, ME Cooper

Journal article  |  1999  |  The American Journal of Pathology

Increased bradykinin and "normal" angiotensin peptide levels in diabetic Sprague-Dawley and transgenic (mRen-2)27 rats

DJ Campbell, DJ Kelly, JL Wilkinson-Berka, ME Cooper, SL Skinner

Journal article  |  1999  |  Kidney International

Localization of secreted protein acidic and rich in cysteine (SPARC) expression in the rat eye

RE Gilbert, AJ Cox, DJ Kelly, JL Wilkinson-Berka, EH Sage, G Jerums, ME Cooper

Journal article  |  1999  |  Connective Tissue Research

Renal expression of transforming growth factor-beta inducible gene-h3 (beta ig-h3) in normal and diabetic rats

RE Gilbert, JL Wilkinson-Berka, DW Johnson, A Cox, T Soulis, LL Wu, DJ Kelly, G Jerums, CA Pollock, ME Cooper

Journal article  |  1998  |  Kidney International

A new model of diabetic nephropathy with progressive renal impairment in the transgenic (mRen-2)27 rat (TGR)

DJ Kelly, JL Wilkinson-Berka, TJ Allen, ME Cooper, SL Skinner

Journal article  |  1998  |  Kidney International

Vascular endothelial growth factor and its receptors in control and diabetic rat eyes

RE Gilbert, D Vranes, JL Berka, DJ Kelly, A Cox, LL Wu, SA Stacker, ME Cooper

Journal article  |  1998  |  Laboratory Investigation

Amylin stimulates proximal tubular sodium transport and cell proliferation in the rat kidney

PJ Harris, ME Cooper, S Hiranyachattada, JL Berka, DJ Kelly, M Nobes, PJ Wookey

Journal article  |  1997  |  American Journal of Physiology

Amylin stimulates proximal tubular sodium transport and cell proliferation in the rat kidney

PJ Harris, ME Cooper, S Hiranyachattada, JL Berka, DJ Kelly, M Nobes, PJ Wookey

Journal article  |  1997  |  American Journal of Physiology-Renal Physiology

Adrenaline cells of the rat adrenal cortex and medulla contain renin and prorenin

JL Berka, DJ Kelly, DB Robinson, D Alcorn, PD Marley, RT Fernley, SL Skinner

Journal article  |  1996  |  Molecular and Cellular Endocrinology

RENIN PROCESSING AND SECRETION IN ADRENAL AND RETINA OF TRANSGENIC (MREN-2)27 RATS

P RONG, JL BERKA, DJ KELLY, D ALCORN, SL SKINNER

Conference Proceedings  |  1994  |  Kidney International

New Treatments for Diabetic Chronic Kidney Disease

Richard J MacIsaac

Journal article  |  Journal of Nephrology & Therapeutics