Darren Kelly

(Hetero)aryl compounds as antifibrotic agents and their preparation, pharmaceutical compositions and use in the treatment of fibrosis

SJ Williams, S Zammit, DJ Kelly, W James

Halogenated cinnamoylbenzamide analogs of anti-fibrotic agents and their preparation

DJ Kelly, SJ Williams, S Zammit

Preparation of cinnamoyl anthranilates and analogs thereof with antifibrotic activity

S ZAMMIT, R GILBERT, H KRUM, S WILLIAMS, D KELLY

RE: Blockade of apoptosis signal-regulating kinase 1 ameliorates cardiac dysfunction in cardiorenal syndrome via enhancing angiogenesis.

Feby Savira, Andrew R Kompa, Amanda J Edgley, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang

Journal article  |  2021  |  International Journal of Cardiology

RE: Inhibition of apoptosis signal-regulating kinase 1 might be a novel therapeutic target in the treatment of cardiorenal syndrome

Feby Savira, Amanda J Edgley, Beat M Jucker, Robert N Willette, Henry Krum, Darren J Kelly, Andrew R Kompa, Bing H Wang

Journal article  |  2021  |  International Journal of Cardiology

RE: ASK1, a new target in treating cardiorenal syndrome (CRS)

Feby Savira, Andrew R Kompa, Amanda J Edgley, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang

Journal article  |  2020  |  International Journal of Cardiology

Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome

Feby Savira, Bing H Wang, Amanda J Edgley, Beat M Jucker, Robert N Willette, Henry Krum, Darren J Kelly, Andrew R Kompa

Conference Proceedings  |  2020  |  International Journal of Cardiology

Oral delivery of the anti-fibrotic, FT011, achieves safe and robust intraocular levels of exposure in subjects undergoing glaucoma filtration surgery

Jennifer Fan Gaskin, Nathan Kerr, Michelle Pauline Papadimitriou, Roy Chze Khai Kong, Fay Lin Khong, Darren Kelly

Conference Proceedings  |  2020  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Oral delivery of a novel small molecule drug, OCX063, protects against vascular leakage and fibrosis in a rodent model of neovascular age-related macular degeneration

Michelle Pauline Papadimitriou, Zsolt Ablonczy, Andy Whitlock, Erica Fletcher, Fay Lin Khong, Darren Kelly

Conference Proceedings  |  2020  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

OCX063, a novel small molecule drug, is protective against inflammatory, fibrotic and angiogenic phenotypes in retinal cultures

Roy Chze Khai Kong, Elsa Chan, Alison J Cox, Sylwia Glowacka, Fay Lin Khong, Michelle Pauline Papadimitriou, Darren Kelly

Conference Proceedings  |  2020  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Cardiorenal syndrome: Multi-organ dysfunction involving the heart, kidney and vasculature

Feby Savira, Ruth Magaye, Danny Liew, Christopher Reid, Darren J Kelly, Andrew R Kompa, S Jeson Sangaralingham, John C Burnett, David Kaye, Bing H Wang

Journal article  |  2020  |  British Journal of Pharmacology

Cardiorenal syndrome (CRS) is a multi-organ disease, encompassing heart, kidney and vascular system dysfunction. CRS is a worldwid..

Spironolactone mitigates, but does not reverse, the progression of renal fibrosis in a transgenic hypertensive rat

Catherine J Leader, Darren J Kelly, Ivan A Sammut, Gerard T Wilkins, Robert J Walker

Journal article  |  2020  |  Physiological Reports

Hypertension plays an important role in the development and progression of chronic kidney disease. Studies to date, with mineraloc..

Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model

Mark T Waddingham, Takashi Sonobe, Hirotsugu Tsuchimochi, Amanda J Edgley, Vijayakumar Sukumaran, Yi Ching Chen, Sarabjit S Hansra, Daryl O Schwenke, Keiji Umetani, Kohki Aoyama, Naoto Yagi, Darren J Kelly, Shahrooz Gaderih, Melissa Herwig, Detmar Kolijn, Andreas Muegge, Walter J Paulus, Takeshi Ogo, Mikiyasu Shirai, Nazha Hamdani, et al.

Journal article  |  2019  |  Journal of Molecular and Cellular Cardiology

Coronary microvessel endothelial dysfunction and nitric oxide (NO) depletion contribute to elevated passive tension of cardiomyocy..