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Prof

Darren Kelly

Professor
Medicine - St Vincent's Hospital
Diabetes
chronic kidney disease
heart failure
angiotensin
hypertension
translational research
biomedical innovation
medical biotechnologies
ocular, renal & cardiovascular research
Darren Kelly's Profile Picture
Prof

Darren Kelly

 
Division
Medicine, Dentistry and Health Sciences
 
Primary Interest
Endocrinology
Darren Kelly's Profile Picture
Prof

Darren Kelly

 
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Darren's  Short Profile
 

Find out more about Darren Kelly's experience

Darren Kelly's highlights

Patents

Displaying the most recent patents by Darren Kelly.

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(Hetero)aryl compounds as antifibrotic agents and their preparation, pharmaceutical compositions and use in the treatment of fibrosis

SJ Williams, S Zammit, DJ Kelly, W James

June 16, 2010
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Halogenated cinnamoylbenzamide analogs of anti-fibrotic agents and their preparation

DJ Kelly, SJ Williams, S Zammit

December 19, 2008
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Preparation of cinnamoyl anthranilates and analogs thereof with antifibrotic activity

S ZAMMIT, R GILBERT, H KRUM, S WILLIAMS, D KELLY

January 10, 2008

3

Patents

Projects

Displaying the 10 most recent projects from 47 for Darren Kelly.

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ADMIER: A NOVEL, POINT-OF-CARE DEVICE TO DIAGNOSE AND SUBTYPE DRY EYE DISEASE

2020 - 2023
Active
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DIHYDROCERAMIDE DESATURASE-1 (DES1) INHIBITORS FOR THE TREATMENT OF FIBROTIC DISEASE

2019 - 2021
Completed
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NOVEL APPROACHES TO THE PREVENTION AND TREATMENT OF CHRONIC HEART DISEASE AND ITS CO-MORBID COMPLICATIONS

Cardiovascular disease (CVD) and its associated additional disorders constitute major public health problems, especially given the rapidly a..

2016 - 2020
Completed
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Developing SPARK Melbourne

2018 - 2019
Completed
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MECHANISMS UNDERLYING THE CONTRIBUTION OF UREMIC TOXINS TO CARDIORENAL SYNDROME

Cardiorenal syndrome (CRS) is an umbrella term that defines disorders of the heart and kidneys whereby “acute or chronic dysfunction in one ..

2015 - 2017
Completed
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Biooanalytical services for OCX071 and OCX063

2016 - 2017
Completed
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PULMONARY MICROVASCULAR PATHOLOGY AS A CAUSE OF EXERCISE LIMITATION IN DIABETICS: IDENTIFICATION WITH A NOVEL ECHOCARDIOGRAPHIC CONTRAST TECHNIQUE AND TREATMENT WITH SILDENAFIL

2013 - 2015
Completed
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INVESTIGATING THE FUNCTIONAL INTERACTION BETWEEN VASOPRESSIN AND ANGIOTENSIN RECEPTORS

Kidney disease resulting from diabetes is a major health issue for Australians, and indigenous Australians in particular. This project aims ..

2012 - 2015
Completed
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TESTING CELL THERAPIES IN THE DIABETIC REN-2 RAT MODEL

2010 - 2015
Completed
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PREVENTION AND TREATMENT OF CHRONIC HEART AND KIDNEY DISEASE VIA EPIDEMIOLOGICAL, PHARMACOLOGICAL DEVICE AND CELL-BASED APPROACHES

Heart failure describes where the heart cannot pump adequately to meet the needs of the body. This condition has a high mortality despite re..

2010 - 2014
Completed

47

Projects

Project Types

27

Research Grant

19

Research Contracts

1

Internal Research Grant

Additional Information

Scholarly Works

Displaying the 10 most recent scholarly works from 274 for Darren Kelly.

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Apoptosis signal-regulating kinase 1 inhibition reverses deleterious indoxyl sulfate-mediated endothelial effects

Feby Savira, Andrew R Kompa, Ruth Magaye, Xin Xiong, Li Huang, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang

Journal article  |  2021  |  LIFE SCIENCES

AIMS: Indoxyl sulfate (IS), a protein-bound uremic toxin, is implicated in endothelial dysfunction, which contributes to adverse c..

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RE: Blockade of apoptosis signal-regulating kinase 1 ameliorates cardiac dysfunction in cardiorenal syndrome via enhancing angiogenesis

Feby Savira, Andrew R Kompa, Amanda J Edgley, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF CARDIOLOGY

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β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat.

James T Pearson, Hamish P Thambyah, Mark T Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P Ngo, Connie PC Ow, Takashi Sonobe, Yi Ching Chen, Amanda J Edgley, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Darren J Kelly, Hirotsugu Tsuchimochi, Mikiyasu Shirai

Journal article  |  2021  |  Clin Sci (Lond)

A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitro..

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RE: Inhibition of apoptosis signal-regulating kinase 1 might be a novel therapeutic target in the treatment of cardiorenal syndrome

Feby Savira, Amanda J Edgley, Beat M Jucker, Robert N Willette, Henry Krum, Darren J Kelly, Andrew R Kompa, Bing H Wang

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF CARDIOLOGY

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beta-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat

James T Pearson, Hamish P Thambyah, Mark T Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P Ngo, Connie PC Ow, Takashi Sonobe, Yi Ching Chen, Amanda J Edgley, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Darren J Kelly, Hirotsugu Tsuchimochi, Mikiyasu Shirai

Journal article  |  2021  |  CLINICAL SCIENCE

A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitro..

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RE: ASK1, a new target in treating cardiorenal syndrome (CRS)

Feby Savira, Andrew R Kompa, Amanda J Edgley, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF CARDIOLOGY

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Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome

Feby Savira, Bing H Wang, Amanda J Edgley, Beat M Jucker, Robert N Willette, Henry Krum, Darren J Kelly, Andrew R Kompa

Journal article  |  2020  |  International Journal of Cardiology

BACKGROUND: Cardiorenal syndrome (CRS) is a major health burden worldwide in need of novel therapies, as current treatments remain..

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Oral delivery of the anti-fibrotic, FT011, achieves safe and robust intraocular levels of exposure in subjects undergoing glaucoma filtration surgery

Jennifer Fan Gaskin, Nathan Kerr, Michelle Pauline Papadimitriou, Roy Chze Khai Kong, Fay Lin Khong, Darren Kelly

Conference Proceedings  |  2020  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

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Oral delivery of a novel small molecule drug, OCX063, protects against vascular leakage and fibrosis in a rodent model of neovascular age-related macular degeneration

Michelle Pauline Papadimitriou, Zsolt Ablonczy, Andy Whitlock, Erica Fletcher, Fay Lin Khong, Darren Kelly

Conference Proceedings  |  2020  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

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OCX063, a novel small molecule drug, is protective against inflammatory, fibrotic and angiogenic phenotypes in retinal cultures

Roy Chze Khai Kong, Elsa Chan, Alison J Cox, Sylwia Glowacka, Fay Lin Khong, Michelle Pauline Papadimitriou, Darren Kelly

Conference Proceedings  |  2020  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

274

Scholarly Works

Keyword Analysis

Clinical Health
Cardiovascular Medicine and Haematology
Clinical Sciences
Medical Physiology
Pharmacology and Pharmaceutical Sciences
Expanding Knowledge
Biochemistry and Cell Biology
Genetics
Medical Biochemistry and Metabolomics
Human Pharmaceutical Products

Honours, Awards and Fellowships

2009

TJ Neale Award for Nephrology Research
2004

Scholarship to study Masters of Business Administration

Universitas 21 Global
2002

Senior Investigator Award

St Vincent's Hospital
2000

Travel Grant to ANZSN DArwin

ANZSN
2000

Travel Grant to Lund, Sweden

Juvenile Diabetes Foundation of Australia
1999

Travel Grant to Miami, USA

Juvenile Diabetes Foundation of Australia
1998

Travel Grant to Amsterdam, The Netherlands

High Blood Pressure Research Council
1998

Travel Grant to Amsterdam, The Netherlands

International Society of Hypertension.
1997

Shepherd M Lowe Scholarship for diabetes research

University of Melbourne
1997

International Travel Grant to Helsinki, Finland and Copenhagen, Denmark

Servier Laboratories.
1997

International Travel Grant to Helsinki, Finland

European Society of Diabetes
1996

Postgraduate Scholarship

Mabel Kent Medical Faculty
1996

International Travel Grant to Glasgow, Scotland

National Heart Foundation
1996

International Travel Grant to Glasgow, Scotland

International Society of Hypertension.
1995

Astra Young Investigator

High Blood Pressure Research Council
2007

FASN - Fellow of the American Society of Nephrology

16

Awards

Credentials

Positions

Professor

Medicine - St Vincent's Hospital

Honorary

Bio21 Institute

Associate Dean (Innovation And Commercialisation)

Medicine, Dentistry and Health Sciences

Member

Ausbiotechnology

Education

Exec Dipl Bus Admin

Universitas 21 Global

Executive Diploma in Business Administration

Universitas 21

Doctor of Philosophy

University of Melbourne

Bachelor of Medical Laboratory Science

Royal Melbourne Institute of Technology

Links

International Linkages

St. Michael's Hospital

Canada

Biotechmedicum, Helsinki

Finland