Darren Kelly

Aryl Hydrocarbon Receptor Inhibition Restores Indoxyl Sulfate-Mediated Endothelial Dysfunction in Rat Aortic Rings

Cindy Nguyen, Amanda J Edgley, Darren J Kelly, Andrew R Kompa

Journal article  |  2022  |  TOXINS

The uremic toxin indoxyl sulfate (IS), elevated in chronic kidney disease (CKD), is known to contribute towards progressive cardio..

Transcriptomic analysis of choroidal neovascularization reveals dysregulation of immune and fibrosis pathways that are attenuated by a novel anti-fibrotic treatment

Alice Brandli, Fay L Khong, Roy CK Kong, Darren J Kelly, Erica L Fletcher

Journal article  |  2022  |  SCIENTIFIC REPORTS

Neovascular AMD (nAMD) leads to vision loss and is a leading cause of visual impairment in the industrialised world. Current treat..

NP202 treatment improves left ventricular systolic function and attenuates pathological remodelling following chronic myocardial infarction

Andrew R Kompa, Fay L Khong, Yuan Zhang, Cindy Nguyen, Amanda J Edgley, Owen L Woodman, Grant McLachlan, Darren J Kelly

Journal article  |  2021  |  LIFE SCIENCES

AIMS: Myocardial injury is a major contributor to left ventricular (LV) remodelling activating neurohormonal and inflammatory proc..

The effect of dihydroceramide desaturase 1 inhibition on endothelial impairment induced by indoxyl sulfate

Feby Savira, Andrew R Kompa, Darren J Kelly, Ruth Magaye, Xin Xiong, Li Huang, Danny Liew, Christopher Reid, David Kaye, Carmen V Scullino, Stuart M Pitson, Bernard L Flynn, Bing H Wang

Journal article  |  2021  |  VASCULAR PHARMACOLOGY

Protein-bound uremic toxins (PBUTs) have adverse effects on vascular function, which is imperative in the progression of cardiovas..

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

C Glenn Begley, Mark Ashton, Jonathan Baell, Michael Bettess, Michael P Brown, Brett Carter, William N Charman, Christopher Davis, Simon Fisher, Ian Frazer, Anand Gautam, Michael P Jennings, Philip Kearney, Eloise Keeffe, Darren Kelly, Angel F Lopez, Michael McGuckin, Michael W Parker, Craig Rayner, Brett Roberts, et al.

Journal article  |  2021  |  SCIENCE TRANSLATIONAL MEDICINE

Drug repurposing is promoted as a cost- and time-effective mechanism for providing new medicines. Often, however, there is insuffi..

Apoptosis signal-regulating kinase 1 inhibition reverses deleterious indoxyl sulfate-mediated endothelial effects

Feby Savira, Andrew R Kompa, Ruth Magaye, Xin Xiong, Li Huang, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang

Journal article  |  2021  |  LIFE SCIENCES

AIMS: Indoxyl sulfate (IS), a protein-bound uremic toxin, is implicated in endothelial dysfunction, which contributes to adverse c..

RE: Blockade of apoptosis signal-regulating kinase 1 ameliorates cardiac dysfunction in cardiorenal syndrome via enhancing angiogenesis

Feby Savira, Andrew R Kompa, Amanda J Edgley, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF CARDIOLOGY

β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat.

James T Pearson, Hamish P Thambyah, Mark T Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P Ngo, Connie PC Ow, Takashi Sonobe, Yi Ching Chen, Amanda J Edgley, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Darren J Kelly, Hirotsugu Tsuchimochi, Mikiyasu Shirai

Journal article  |  2021  |  Clin Sci (Lond)

A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitro..

RE: Inhibition of apoptosis signal-regulating kinase 1 might be a novel therapeutic target in the treatment of cardiorenal syndrome

Feby Savira, Amanda J Edgley, Beat M Jucker, Robert N Willette, Henry Krum, Darren J Kelly, Andrew R Kompa, Bing H Wang

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF CARDIOLOGY

beta-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat

James T Pearson, Hamish P Thambyah, Mark T Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P Ngo, Connie PC Ow, Takashi Sonobe, Yi Ching Chen, Amanda J Edgley, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Darren J Kelly, Hirotsugu Tsuchimochi, Mikiyasu Shirai

Journal article  |  2021  |  CLINICAL SCIENCE

A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitro..