Simon Drew

Intermediate Cu(II)-Thiolate Species in the Reduction of Cu(II)GHK by Glutathione: A Handy Chelate for Biological Cu(II) Reduction

Iwona Ufnalska, Simon C Drew, Igor Zhukov, Kosma Szutkowski, Urszula E Wawrzyniak, Wojciech Wroblewski, Tomasz Fraczyk, Wojciech Bal

Journal article  |  2021  |  INORGANIC CHEMISTRY

Gly-His-Lys (GHK) is a tripeptide present in the human bloodstream that exhibits a number of biological functions. Its activity is..

Ternary Cu2 Complexes of Human Serum Albumin and Glycyl-L-histidyl-L-lysine

Karolina Bossak-Ahmad, Wojciech Bal, Tomasz Fraczyk, Simon C Drew

Journal article  |  2021  |  INORGANIC CHEMISTRY

Human serum albumin (HSA) and the growth factor glycyl-l-histidyl-l-lysine (GHK) bind Cu2+ as part of their normal functions. GHK ..

Aldehyde Production as a Calibrant of Ultrasonic Power Delivery During Protein Misfolding Cyclic Amplification (vol 39, pg 501, 2020)

Simon C Drew

Journal article  |  2021  |  PROTEIN JOURNAL

In the original version of this article, two minor errors appear in the figure captions. Corrected text: Fig. 3 Formaldehyde measu..

Aldehyde Production as a Calibrant of Ultrasonic Power Delivery During Protein Misfolding Cyclic Amplification

Simon C Drew

Journal article  |  2020  |  PROTEIN JOURNAL

The protein misfolding cyclic amplification (PMCA) technique employs repeated cycles of incubation and sonication to amplify minut..

Ternary Cu(II) Complex with GHK Peptide andCis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate

Karolina Bossak-Ahmad, Marta D Wisniewska, Wojciech Bal, Simon C Drew, Tomasz Fraczyk

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The tripeptide NH2-Gly-His-Lys-COOH (GHK), cis-urocanic acid (cis-UCA) and Cu(II) ions are physiological constituents of the human..

The Sub-picomolar Cu2 Dissociation Constant of Human Serum Albumin

Karolina Bossak-Ahmad, Tomasz Fraczyk, Wojciech Bal, Simon C Drew

Journal article  |  2019  |  CHEMBIOCHEM

The apparent affinity of human serum albumin (HSA) for divalent copper has long been the subject of great interest, due to its pre..

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe

Mansura Akter, Nyssa Drinkwater, Shane M Devine, Simon C Drew, Bankala Krishnarjuna, Cael O Debono, Geqing Wang, Martin J Scanlon, Peter J Scammells, Sheena McGowan, Christopher A MacRaild, Raymond S Norton

Journal article  |  2019  |  CHEMMEDCHEM

Apical membrane antigen 1 (AMA1) is essential for the invasion of host cells by malaria parasites. Several small-molecule ligands ..

Oligopeptides Generated by Neprilysin Degradation of beta-Amyloid Have the Highest Cu(II) Affinity in the Whole A beta Family

Karolina Bossak-Ahmad, Mariusz Mital, Dawid Plonka, Simon C Drew, Wojciech Bal

Journal article  |  2019  |  INORGANIC CHEMISTRY

The catabolism of β-amyloid (Aβ) is carried out by numerous endopeptidases including neprilysin, which hydrolyzes peptide bonds pr..

The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(ii) from albumin. Implications for copper uptake by Ctr1

Ewelina Stefaniak, Dawid Plonka, Simon C Drew, Karolina Bossak-Ahmad, Kathryn L Haas, M Jake Pushie, Peter Faller, Nina E Wezynfeld, Wojciech Bal

Journal article  |  2018  |  METALLOMICS

Human cells acquire copper primarily via the copper transporter 1 protein, hCtr1. We demonstrate that at extracellular pH 7.4 CuII..

Structural Insight into Redox Dynamics of Copper Bound N-Truncated Amyloid-beta Peptides from in Situ X-ray Absorption Spectroscopy

Victor A Streltsov, Ruwini SK Ekanayake, Simon C Drew, Christopher T Chantler, Stephen P Best

Journal article  |  2018  |  INORGANIC CHEMISTRY

X-ray absorption spectroscopy of CuII amyloid-β peptide (Aβ) under in situ electrochemical control (XAS-EC) has allowed elucidatio..