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A/Prof

Heung-Chin Cheng

Associate Professor
Biochemistry and cell signaling
Signal Transduction
Enzymology
Parkinson's disease
Cancer
Protein Kinases
Phosphatases
science & technology
life sciences & biomedicine
Heung-Chin Cheng's Profile Picture
A/Prof

Heung-Chin Cheng

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Parkinson'S Disease
Heung-Chin Cheng's Profile Picture
A/Prof

Heung-Chin Cheng

 

Heung-Chin Cheng has been studying the biochemical basis of regulation of protein kinases and phosphatases since he was a graduate student in Dr Donal Walsh's laboratory in the University of California, Davis in 1982. His PhD project unravelled the active site structure of cAMP-dependent protein kinase, how the kinase recognises its protein substrates and how the kinase is selectively inhibited by its endogenous inhibitor.

His work contributed to the determination of the crystal structure of the catalytic sub-unit of the kinase. In 1987, he joined Dr. Choh Hao Li's laboratory in the University of California at San Francisco as a postdoctoral fellow and work on a project to characterise the beta-endorphin receptor. After Dr. Li's untimely death, he joined Dr. Jerry Wang's laboratory as MRC postdoctoral fellow. When he was in Dr Jerry Wang's laboratory in the University of Calgary, he extended his interest into protein tyrosine kinases and phosphatases. He defined the substrate selectivity determinants of the Src-family kinases.

After he joined the University of Melbourne, Heung-Chin continued to study how Src-family kinases are regulated by their endogenous inhibitors CSK and CHK. His group identified two new auto phosphorylation sites in the kinases and discovered for the first time that CHK employed a unique non-catalytic mechanism to inhibit Src-family kinase activity. An Associate Professor with the Department of Biochemistry and Molecular Biology, Heung-Chin relocated his research group to the Bio21 Institute in 2005. Since then, his group has been studying the enzymology of two protein kinases, PINK1 and LRRK2, involved in the pathogenesis of Parkinson's disease. In addition to protein kinases, his group is active in studying the catalytic and regulatory properties of the tumour suppressor phosphatase PTEN.

Projects

Displaying the 15 most recent projects by Heung-Chin Cheng.

15

Projects

Project Types


13

Research Grant


2

Internal Research Grant


Scholarly Works

Displaying the 82 most recent scholarly works by Heung-Chin Cheng.

Honours, Awards and Fellowships

1999

Union of International Cancer Council Visiting fellowship

1989

Postdoctoral fellowship

Alberta Heritage Foundation for Medical Research

1989

Postdoctoral fellowship

Medical Research Council of Canada

3

Awards

Credentials

Positions


Associate Professor

Biochemistry And Molecular Biology

Academic Teaching And Research

Bio21 Institute

Member

Australian Neuorscience Society

Member

Internaional Neurochemistry Society

Member

American society for Biochemistry and Molecular Biology

Fellow/Recipient Of Uicc Cancer Research Fellowship/Assessor Of Fellowship Applications

Union of Internation Cancer Control

Member

Australian society for Biochemistry and Molecular Biology

Education


Doctor of Philosophy

University of California - Davis

Bachelor of Science

No Data Found - ValueSetID [1009118] FlexValue [356] ParentLow [Hong Kong]