profile icon
A/Prof

Heung-Chin Cheng

Honorary
Biochemistry and Pharmacology
Biochemistry and cell signaling
Signal Transduction
Enzymology
Parkinson's disease
Cancer
Protein Kinases
Phosphatases
science & technology
life sciences & biomedicine
Heung-Chin Cheng's Profile Picture
A/Prof

Heung-Chin Cheng

 
Division
Medicine, Dentistry and Health Sciences
 
Primary Interest
Enzymology of protein kinases and phosphatases involved in cancer and neurodegeneration
Heung-Chin Cheng's Profile Picture
A/Prof

Heung-Chin Cheng

 
Print
Heung-Chin's  Short Profile
 

Find out more about Heung-Chin Cheng's experience

Heung-Chin Cheng's highlights

Projects

Displaying the 10 most recent projects from 16 for Heung-Chin Cheng.

Project icon

Decoding the rogue cellular signals of Zika virus in infected neurons and neural progenitor cells by quantitative proteomics and FDA-approved drugs

2019 - 2021
Completed
Project icon

A new function for an old enzyme: Src Protein Kinase directs excitotoxic neuronal death in stroke

In our previous investigation of how brain cells die in patients suffering from stroke, we found that stroke causes aberrant activation of a..

2013 - 2016
Completed
Project icon

SELF-REPORTING FLUORESCENT CHEMONSENSOR PEPTIDE SUBSTRATES AS MOLECULAR SENSORS OF SRC KINASE ACTIVITY IN PLATELETS - DEVELOPMETN OF A SENSITIVE AND RELIABLE ASSAY OF PLATELET FUNCTION

2012 - 2012
Completed
Project icon

How active LRRK2 causes Parkinson's disease

Parkinson's disease afflicts 100,000 Australians. Mutations in the recently identified enzyme Leucine-rich Repeat Kinase-2 are a common caus..

2009 - 2012
Completed
Project icon

Testing a new HIV/AIDS inhibitor

HIV hijacks infected blood cells to produce its own proteins. Nef is one of these proteins and Nef alone is sufficient to cause an AIDS-like..

2008 - 2011
Completed
Project icon

Role of PTEN in neuronal cell death

In stroke patients, oxygen deprivation indirectly induces massive nerve cell death by activating a cell death-promoting enzyme called PTEN. ..

2008 - 2011
Completed
Project icon

How does inactivation of PINK1 cause Parkinson's disease?

Parkinson's disease is caused by premature death of nerve cells that control body movements. The enzyme PINK1 protects against nerve cell de..

2009 - 2011
Completed
Project icon

DECIPHERING THE BIOCHEMICAL PROPERTIES OF PARKINSONS DISEASE-ASSOCIATED LEUCINE-RICH REPEAT KINASE 2

2008 - 2008
Completed
Project icon

TARGET IDENTIFICATION OF THE MITOCHONDRIAL PARKINSON'S DISEASE PTEN-INDUCED KINASE 1

2007 - 2008
Completed
Project icon

Novel upstream regulatory and down-stream signaling mechanisms of the Src-family protein kinases

Normal cell growth and division are governed by the balanced action of two groups of enzymes - the enzymes encoded by the proto-oncogenes (p..

16

Projects

Project Types

14

Research Grant

2

Internal Research Grant

Additional Information

Scholarly Works

Displaying the 10 most recent scholarly works from 89 for Heung-Chin Cheng.

Scholarly works icon

Phosphomatics: interactive interrogation of substrate-kinase networks in global phosphoproteomics datasets

Michael G Leeming, Sean O'Callaghan, Luana Licata, Marta Iannuccelli, Prisca Lo Surdo, Elisa Micarelli, Ching-Seng Ang, Shuai Nie, Swati Varshney, Sadia Ameen, Heung-Chin Cheng, Nicholas A Williamson

Journal article  |  2021  |  BIOINFORMATICS

MOTIVATION: Mass spectrometry-based phosphoproteomics can routinely identify and quantify thousands of phosphorylated peptides fro..

Scholarly works icon

CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation

Anderly C Chueh, Gahana Advani, Momeneh Foroutan, Jai Smith, Nadia Ng, Harshal Nandurkar, Daisy S Lio, Hong-Jian Zhu, Yuh-Ping Chong, Heather Verkade, Donald J Fujita, Jeffrey Bjorge, Faiza Basheer, Jet Phey Lim, Ian Luk, Amardeep Dhillon, Anuratha Sakthianandeswaren, Dmitri Mouradov, Oliver Sieber, Frederic Hollande, et al.

Journal article  |  2021  |  ONCOGENE

Hyperactivation of SRC-family protein kinases (SFKs) contributes to the initiation and progression of human colorectal cancer (CRC..

Scholarly works icon

The structure of the extracellular domains of human interleukin 11? receptor reveals mechanisms of cytokine engagement

Riley D Metcalfe, Kaheina Aizel, Courtney O Zlatic, Paul M Nguyen, Craig J Morton, Daisy Sio-Seng Lio, Heung-Chin Cheng, Renwick CJ Dobson, Michael W Parker, Paul R Gooley, Tracy L Putoczki, Michael DW Griffin

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex with its cell surface α-receptor, IL-..

Scholarly works icon

Modulating inflammation after stroke to support brain rescue and functional recovery: emerging targets include Rho Kinase

Carli Roulston, Mohammed Iqbal Hossain, Ching-Seng Ang, Ellie Phillips, Laita Bokhari, Heung Chin Cheng, Philip Beart

Conference Proceedings  |  2019  |  INTERNATIONAL JOURNAL OF STROKE

Scholarly works icon

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

Matthew Ku, Ruth N MacKinnon, Meaghan Wall, Nisha Narayan, Carl Walkley, Heung-Chin Cheng, Lynda J Campbell, Louise E Purton, Harshal Nandurkar

Journal article  |  2019  |  SCIENTIFIC REPORTS

Deletion of long arm of chromosome 20 [del(20q)] is the second most frequent recurrent chromosomal abnormality in hematological ma..

Scholarly works icon

Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death

Ashfaqul Hoque, Nicholas A Williamson, S Sadia Ameen, Giuseppe D Ciccotosto, M Iqbal Hossain, Jonathan S Oakhill, Dominic CH Ng, Ching-Seng Ang, Heung-Chin Cheng

Journal article  |  2019  |  CELL DEATH & DISEASE

Excitotoxicity, caused by overstimulation or dysregulation of ionotropic glutamate receptors (iGluRs), is a pathological process d..

Scholarly works icon

The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties

Ryan D Mills, Lung-Yu Liang, Daisy Sio-Seng Lio, Yee-Foong Mok, Terrence D Mulhern, George Cao, Michael Griffin, Vijaya B Kenche, Janetta G Culvenor, Heung-Chin Cheng

Journal article  |  2018  |  JOURNAL OF NEUROCHEMISTRY

The Parkinson's disease (PD)-causative leucine-rich repeat kinase 2 (LRRK2) belongs to the Roco family of G-proteins comprising a ..

Scholarly works icon

CSK-Homologous Kinase

Heung-Chin Cheng, Gahana Advani, Mohammed Iqbal Hossain, Nadia LY Ng, Ya Chee Lim, Anderly C Chüeh, Mohd Aizuddin Kamaruddin, Yuh-Ping Chong

Book Chapter  |  2018

Scholarly works icon

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

Gahana Advani, Ya Chee Lim, Bruno Catimel, Daisy Sio Seng Lio, Nadia LY Ng, Anderly C Chueh, Mai Tran, Mohd Ishtiaq Anasir, Heather Verkade, Hong-Jian Zhu, Benjamin E Turk, Thomas E Smithgall, Ching-Seng Ang, Michael Griffin, Heung-Chin Cheng

Journal article  |  2017  |  CELL COMMUNICATION AND SIGNALING

BACKGROUND: C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases ..

Scholarly works icon

A beacon of hope in stroke therapy Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies

Ashfaqul Hoque, M Iqbal Hossain, S Sadia Ameen, Ching-Seng Ang, Nicholas Williamson, Dominic CH Ng, Anderly C Chueh, Carli Roulston, Heung-Chin Cheng

Journal article  |  2016  |  PHARMACOLOGY & THERAPEUTICS

Excitotoxicity, a pathological process caused by over-stimulation of ionotropic glutamate receptors, is a major cause of neuronal ..

89

Scholarly Works

Keyword Analysis

Clinical Health
Biochemistry and Cell Biology
Neurosciences
Oncology and Carcinogenesis
Expanding Knowledge
Medical Biochemistry and Metabolomics
Other Health
Clinical Sciences
Medicinal and Biomolecular Chemistry
Pharmacology and Pharmaceutical Sciences

Honours, Awards and Fellowships

1999

Union of International Cancer Council Visiting fellowship
1989

Postdoctoral fellowship

Alberta Heritage Foundation for Medical Research
1989

Postdoctoral fellowship

Medical Research Council of Canada

3

Awards

Credentials

Positions

Honorary

Biochemistry and Pharmacology

Member

Australian Neuorscience Society

Member

Internaional Neurochemistry Society

Member

American society for Biochemistry and Molecular Biology

Education

Doctor of Philosophy

University of California - Davis

Links