Heung-Chin Cheng

Phosphomatics: interactive interrogation of substrate-kinase networks in global phosphoproteomics datasets.

Michael G Leeming, Sean O'Callaghan, Luana Licata, Marta Iannuccelli, Prisca Lo Surdo, Elisa Micarelli, Ching-Seng Ang, Shuai Nie, Swati Varshney, Sadia Ameen, Heung-Chin Cheng, Nicholas A Williamson

Journal article  |  2021  |  Bioinformatics

MOTIVATION: Mass spectrometry-based phosphoproteomics can routinely identify and quantify thousands of phosphorylated peptides fro..

CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation

Anderly C Chueh, Gahana Advani, Momeneh Foroutan, Jai Smith, Nadia Ng, Harshal Nandurkar, Daisy S Lio, Hong-Jian Zhu, Yuh-Ping Chong, Heather Verkade, Donald J Fujita, Jeffrey Bjorge, Faiza Basheer, Jet Phey Lim, Ian Luk, Amardeep Dhillon, Anuratha Sakthianandeswaren, Dmitri Mouradov, Oliver Sieber, Frederic Hollande, et al.

Journal article  |  2021  |  ONCOGENE

Hyperactivation of SRC-family protein kinases (SFKs) contributes to the initiation and progression of human colorectal cancer (CRC..

An Atlas of Phosphorylation and Proteolytic Processing Events During Excitotoxic Neuronal Death Reveals New Therapeutic Opportunities

Sadia Ameen, Antoine Dufour, Iqbal Hossain, Ashfaqul Hoque, Sharelle Sturgeon, Harshal Nandurkar, Dominik Draxler, Robert Medcalf, Mohd Aizuddin Kamaruddin, Isabelle Lucet, Michael Leeming, Dazhi Liu, Amardeep Dhillon, Jet Phey Lim, Hong-Jian Zhu, Laita Bokhari, Carli Roulston, Oded Kleifeld, Ciccotosto Giuseppe, Nicholas Williamson, et al.

Journal article  |  2020

Summary Excitotoxicity, a neuronal death process in neurological disorders, is initiated by over-stimulation of neuronal ionotropi..

The structure of the extracellular domains of human interleukin 11? receptor reveals mechanisms of cytokine engagement

Riley D Metcalfe, Kaheina Aizel, Courtney O Zlatic, Paul M Nguyen, Craig J Morton, Daisy Sio-Seng Lio, Heung-Chin Cheng, Renwick CJ Dobson, Michael W Parker, Paul R Gooley, Tracy L Putoczki, Michael DW Griffin

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex with its cell surface α-receptor, IL-..

Modulating inflammation after stroke to support brain rescue and functional recovery: emerging targets include Rho Kinase

Carli Roulston, Mohammed Iqbal Hossain, Ching-Seng Ang, Ellie Phillips, Laita Bokhari, Heung Chin Cheng, Philip Beart

Conference Proceedings  |  2019  |  INTERNATIONAL JOURNAL OF STROKE

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

Matthew Ku, Ruth N MacKinnon, Meaghan Wall, Nisha Narayan, Carl Walkley, Heung-Chin Cheng, Lynda J Campbell, Louise E Purton, Harshal Nandurkar

Journal article  |  2019  |  SCIENTIFIC REPORTS

Deletion of long arm of chromosome 20 [del(20q)] is the second most frequent recurrent chromosomal abnormality in hematological ma..

Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death

Ashfaqul Hoque, Nicholas A Williamson, S Sadia Ameen, Giuseppe D Ciccotosto, M Iqbal Hossain, Jonathan S Oakhill, Dominic CH Ng, Ching-Seng Ang, Heung-Chin Cheng

Journal article  |  2019  |  CELL DEATH & DISEASE

Excitotoxicity, caused by overstimulation or dysregulation of ionotropic glutamate receptors (iGluRs), is a pathological process d..

The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties

Ryan D Mills, Lung-Yu Liang, Daisy Sio-Seng Lio, Yee-Foong Mok, Terrence D Mulhern, George Cao, Michael Griffin, Vijaya B Kenche, Janetta G Culvenor, Heung-Chin Cheng

Journal article  |  2018  |  JOURNAL OF NEUROCHEMISTRY

The Parkinson's disease (PD)-causative leucine-rich repeat kinase 2 (LRRK2) belongs to the Roco family of G-proteins comprising a ..

Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

Gahana Advani, Ya Chee Lim, Bruno Catimel, Daisy Sio Seng Lio, Nadia LY Ng, Anderly C Chueh, Mai Tran, Mohd Ishtiaq Anasir, Heather Verkade, Hong-Jian Zhu, Benjamin E Turk, Thomas E Smithgall, Ching-Seng Ang, Michael Griffin, Heung-Chin Cheng

Journal article  |  2017  |  CELL COMMUNICATION AND SIGNALING

BACKGROUND: C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases ..

A beacon of hope in stroke therapy Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies

Ashfaqul Hoque, M Iqbal Hossain, S Sadia Ameen, Ching-Seng Ang, Nicholas Williamson, Dominic CH Ng, Anderly C Chueh, Carli Roulston, Heung-Chin Cheng

Journal article  |  2016  |  PHARMACOLOGY & THERAPEUTICS

Excitotoxicity, a pathological process caused by over-stimulation of ionotropic glutamate receptors, is a major cause of neuronal ..