Michael Parker

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome

Stanley C Xie, Riley D Metcalfe, Hirotake Mizutani, Tanya Puhalovich, Eric Hanssen, Craig J Morton, Yawei Du, Con Dogovski, Shih-Chung Huang, Jeffrey Ciavarri, Paul Hales, Robert J Griffin, Lawrence H Cohen, Bei-Ching Chuang, Sergio Wittlin, Ioanna Deni, Tomas Yeo, Kurt E Ward, Daniel C Barry, Boyin Liu, et al.

Journal article  |  2021  |  Proceedings of the National Academy of Sciences

The Plasmodium falciparum proteasome is a potential antimalarial drug target. We have identified a series of amino-amide boronates..

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers.

C Glenn Begley, Mark Ashton, Jonathan Baell, Michael Bettess, Michael P Brown, Brett Carter, William N Charman, Christopher Davis, Simon Fisher, Ian Frazer, Anand Gautam, Michael P Jennings, Philip Kearney, Eloise Keeffe, Darren Kelly, Angel F Lopez, Michael McGuckin, Michael W Parker, Craig Rayner, Brett Roberts, et al.

Journal article  |  2021  |  Sci Transl Med

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Development of [18F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease

Siu Wai Wong, Lucy Vivash, Ramesh Mudududdla, Nghi Nguyen, Stefan J Hermans, David M Shackleford, Judith Field, Lian Xue, Andrea Aprico, Nancy C Hancock, Mohammad Haskali, Michael A Stashko, Stephen V Frye, Xiaodong Wang, Michele D Binder, Uwe Ackermann, Michael W Parker, Trevor J Kilpatrick, Jonathan B Baell

Journal article  |  2021  |  European Journal of Medicinal Chemistry

Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome

Yin-Huai Chen, Diane B Zastrow, Riley D Metcalfe, Lisa Gartner, Freia Krause, Craig J Morton, Shruti Marwaha, Laure Fresard, Yong Huang, Chunli Zhao, Colleen McCormack, David Bick, Elizabeth A Worthey, Christine M Eng, Jessica Gold, Stephen B Montgomery, Paul G Fisher, Euan A Ashley, Matthew T Wheeler, Michael W Parker, et al.

Journal article  |  2021  |  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

BACKGROUND: Biallelic variants in IL6ST, encoding GP130, cause a recessive form of hyper-IgE syndrome (HIES) characterized by high..

Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster

Trent Perry, Wei Chen, Razi Ghazali, Ying Ting Yang, Danielle Christesen, Felipe Martelli, Chris Lumb, Hang Ngoc Bao Luong, Judith Mitchell, Jessica K Holien, Michael W Parker, Thomas C Sparks, Philip Batterham

Journal article  |  2021  |  INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Insecticides remain valuable tools for the control of insect pests that significantly impact human health and agriculture. A deepe..

An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability

Zsuzsanna Nagy, Janith A Seneviratne, Maxwell Kanikevich, William Chang, Chelsea Mayoh, Pooja Venkat, Yanhua Du, Cizhong Jiang, Alice Salib, Jessica Koach, Daniel R Carter, Rituparna Mittra, Tao Liu, Michael W Parker, Belamy B Cheung, Glenn M Marshall

Journal article  |  2021  |  NATURE COMMUNICATIONS

To achieve the very high oncoprotein levels required to drive the malignant state cancer cells utilise the ubiquitin proteasome sy..

A DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction

Patrick M Siegel, Istvan Bojti, Nicole Bassler, Jessica Holien, Ulrike Flierl, Xiaowei Wang, Philipp Waggershauser, Xavier Tonnar, Christopher Vedecnik, Constanze Lamprecht, Ivana Stankova, Tian Li, Thomas Helbing, Dennis Wolf, Nathaly Anto-Michel, Lucia Sol Mitre, Julia Ehrlich, Lukas Orlean, Ileana Bender, Anne Przewosnik, et al.

Journal article  |  2021  |  BASIC RESEARCH IN CARDIOLOGY

The monocyte β2-integrin Mac-1 is crucial for leukocyte-endothelium interaction, rendering it an attractive therapeutic target for..

A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma

Belamy B Cheung, Ane Kleynhans, Rituparna Mittra, Patrick Y Kim, Jessica K Holien, Zsuzsanna Nagy, Olivia C Ciampa, Janith A Seneviratne, Chelsea Mayoh, Mukesh Raipuria, Satyanarayana Gadde, Hassina Massudi, Iris Poh Ling Wong, Owen Tan, Andrew Gong, Aldwin Suryano, Sonya M Diakiw, Bing Liu, Greg M Arndt, Tao Liu, et al.

Journal article  |  2021  |  ONCOGENE

Histone deacetylase (HDAC) inhibitors are effective in MYCN-driven cancers, because of a unique need for HDAC recruitment by the M..

X-ray crystallography shines a light on pore-forming toxins.

Bronte A Johnstone, Michelle P Christie, Craig J Morton, Michael W Parker

Book Chapter  |  2021  |  Methods in Enzymology

A common form of cellular attack by pathogenic bacteria is to secrete pore-forming toxins (PFTs). Capable of forming transmembrane..

CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins

Christopher G Langendorf, Matthew T O'Brien, Kevin RW Ngoei, Luke M McAloon, Urmi Dhagat, Ashfaqul Hoque, Naomi XY Ling, Toby A Dite, Sandra Galic, Kim Loh, Michael W Parker, Jonathan S Oakhill, Bruce E Kemp, John W Scott

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The calcium-calmodulin-dependent protein kinase kinase-2 (CaMKK2) is a key regulator of cellular and whole-body energy metabolism...