Michael Parker

Role of nicotinic acetylcholine receptor subunits in the mode of action of neonicotinoid, sulfoximine and spinosyn insecticides in Drosophila melanogaster.

Trent Perry, Wei Chen, Razi Ghazali, Ying Ting Yang, Danielle Christesen, Felipe Martelli, Chris Lumb, Hang Ngoc Bao Luong, Judith Mitchell, Jessica K Holien, Michael W Parker, Thomas C Sparks, Philip Batterham

Journal article  |  2021  |  Insect Biochemistry and Molecular Biology

Insecticides remain valuable tools for the control of insect pests that significantly impact human health and agriculture. A deepe..

An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability.

Zsuzsanna Nagy, Janith A Seneviratne, Maxwell Kanikevich, William Chang, Chelsea Mayoh, Pooja Venkat, Yanhua Du, Cizhong Jiang, Alice Salib, Jessica Koach, Daniel R Carter, Rituparna Mittra, Tao Liu, Michael W Parker, Belamy B Cheung, Glenn M Marshall

Journal article  |  2021  |  Nature Communications

To achieve the very high oncoprotein levels required to drive the malignant state cancer cells utilise the ubiquitin proteasome sy..

Functional and structural analysis of cytokine selective IL6ST defects that cause recessive hyper-IgE syndrome.

Yin-Huai Chen, Diane B Zastrow, Riley D Metcalfe, Lisa Gartner, Freia Krause, Craig J Morton, Shruti Marwaha, Laure Fresard, Yong Huang, Chunli Zhao, Colleen McCormack, David Bick, Elizabeth A Worthey, Christine M Eng, Jessica Gold, undefined Undiagnosed Diseases Network, Stephen B Montgomery, Paul G Fisher, Euan A Ashley, Matthew T Wheeler, et al.

Journal article  |  2021  |  Journal of Allergy and Clinical Immunology

BACKGROUND: Biallelic variants in IL6ST cause a recessive form of hyper-IgE syndrome (HIES) characterized by high IgE, eosinophili..

A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma

Belamy B Cheung, Ane Kleynhans, Rituparna Mittra, Patrick Y Kim, Jessica K Holien, Zsuzsanna Nagy, Olivia C Ciampa, Janith A Seneviratne, Chelsea Mayoh, Mukesh Raipuria, Satyanarayana Gadde, Hassina Massudi, Iris Poh Ling Wong, Owen Tan, Andrew Gong, Aldwin Suryano, Sonya M Diakiw, Bing Liu, Greg M Arndt, Tao Liu, et al.

Journal article  |  2021  |  Oncogene

Histone deacetylase (HDAC) inhibitors are effective in MYCN-driven cancers, because of a unique need for HDAC recruitment by the M..

X-ray crystallography shines a light on pore-forming toxins.

Bronte A Johnstone, Michelle P Christie, Craig J Morton, Michael W Parker

Book Chapter  |  2021  |  Methods in Enzymology

A common form of cellular attack by pathogenic bacteria is to secrete pore-forming toxins (PFTs). Capable of forming transmembrane..

CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins

Christopher G Langendorf, Matthew T O'Brien, Kevin RW Ngoei, Luke M McAloon, Urmi Dhagat, Ashfaqul Hoque, Naomi XY Ling, Toby A Dite, Sandra Galic, Kim Loh, Michael W Parker, Jonathan S Oakhill, Bruce E Kemp, John W Scott

Journal article  |  2020  |  Journal of Biological Chemistry

The calcium-calmodulin-dependent protein kinase kinase-2 (CaMKK2) is a key regulator of cellular and whole-body energy metabolism...

A structural view of PA2G4 isoforms with opposing functions in cancer

Brendan W Stevenson, Michael A Gorman, Jessica Koach, Belamy B Cheung, Glenn M Marshall, Michael W Parker, Jessica K Holien

Journal article  |  2020  |  Journal of Biological Chemistry

The role of proliferation-associated protein 2G4 (PA2G4), alternatively known as ErbB3-binding protein 1 (EBP1), in cancer has bec..

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK beta 1 isoforms

Stephen L Pinkosky, John W Scott, Eric M Desjardins, Brennan K Smith, Emily A Day, Rebecca J Ford, Christopher G Langendorf, Naomi XY Ling, Tracy L Nero, Kim Loh, Sandra Galic, Ashfaqul Hoque, William J Smiles, Kevin RW Ngoei, Michael W Parker, Yan Yan, Karsten Melcher, Bruce E Kemp, Jonathan S Oakhill, Gregory R Steinberg

Journal article  |  2020  |  Nature Metabolism

Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and s..

A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins

Jordan C Evans, Bronte A Johnstone, Sara L Lawrence, Craig J Morton, Michelle P Christie, Michael W Parker, Rodney K Tweten

Journal article  |  2020  |  mBio

The cholesterol-dependent cytolysins (CDCs) are bacterial, β-barrel, pore-forming toxins. A central enigma of the pore-forming mec..

The structure of the extracellular domains of human interleukin 11? receptor reveals mechanisms of cytokine engagement

Riley D Metcalfe, Kaheina Aizel, Courtney O Zlatic, Paul M Nguyen, Craig J Morton, Daisy Sio-Seng Lio, Heung-Chin Cheng, Renwick CJ Dobson, Michael W Parker, Paul R Gooley, Tracy L Putoczki, Michael DW Griffin

Journal article  |  2020  |  Journal of Biological Chemistry

Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex with its cell surface α-receptor, IL-..