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Prof

Stephen Kent

Professorial Fellow
vaccines
Strains
Immunity
differences in killing kinetics across HIV vaccines
Influenza
Antibodies
functions
protection. pneumonia
HIV
Stephen Kent's Profile Picture
Prof

Stephen Kent

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
How fast do anti-HIV T cells kill infected cells?
Stephen Kent's Profile Picture
Prof

Stephen Kent

 

Professor Kent trained as an infectious diseases physician, immunologist and HIV vaccine scientist in Melbourne and the USA. As a physician-scientist he is national leader in developing and testing HIV vaccines and is internationally recognised in this important field.

He developed and manages a biologically secure facility to test promising HIV vaccines, one of very few in the Southern hemisphere. Vaccine concepts tested in recent years have shown sufficient promise to progress into human clinical trials. Further, his lab has developed exciting leads on analysing immune responses and immune evasion from HIV that provide unique insights into the usefulness of various immune responses. This in turn helps guide better vaccine design. Dr Kent~s group has over 150 scientific publications. Dr Kent is confident that one day, with sufficient intellectual capability and effort worldwide, we will be able to provide protection from HIV and AIDS through vaccination. Dr Kent remains active in infectious diseases clinical medicine at the Alfred Hospital and Melbourne Sexual Health Centre, caring for people with HIV/AIDS and assisting in the clinical development of new vaccine strategies. He keeps active hiking, biking and running.Dr Kent manages a vibrant laboratory of Post-doctoral fellows, research assistants and students. Stephen was recently honored to recieve the Peter Doherty Outstanding PhD Supervisor award from the University of Melbourne and a National Citation for Outstanding Contribution to Student Learning, reflecting the good fortune he~s had to have a great crop of PhD studentsand dedicated staff come through the lab. Recent news from the lab can be found at the website: http://www.microbiol.unimelb.edu.au/research/virology/kent/index.html

Projects

Displaying the 73 most recent projects by Stephen Kent.

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Bespoke Nanomaterials For Understanding Nano-Bio Interactions Under Flow

2020 - 2023
Active
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Identifying Plasma Proteins Bound To Nanoparticles

2019 - 2020
Active
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Effects Of Hiv Siv On Unconventional T Cells In Immunity To M. Tuberculosis In Pre Adolescents

2019 - 2024
Active
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Effects Of Hiv Siv On Unconventional T Cells In Immunity To M. Tuberculosis In Pre Adolescents

2019 - 2024
Active
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Immune Responses In Latent And Active Tuberculosis

2019 - 2022
Active
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Addressing The Major Challenges In Hiv Vaccine And Cure Research

HIV remains one of the defining global health challenge of our times. 37 million people are living with HIV with 2 million new infections ea..

2019 - 2023
Active
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Addressing The Major Challenges In Hiv Vaccine And Cure Research

HIV remains one of the defining global health challenge of our times. 37 million people are living with HIV with 2 million new infections ea..

2019 - 2023
Active
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Addressing The Major Challenges In Hiv Vaccine And Cure Research

HIV remains one of the defining global health challenge of our times. 37 million people are living with HIV with 2 million new infections ea..

2019 - 2023
Active
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Addressing The Major Challenges In Hiv Vaccine And Cure Research

HIV remains one of the defining global health challenge of our times. 37 million people are living with HIV with 2 million new infections ea..

2019 - 2023
Active
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Addressing The Major Challenges In Hiv Vaccine And Cure Research

HIV remains one of the defining global health challenge of our times. 37 million people are living with HIV with 2 million new infections ea..

2019 - 2023
Active
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Expression Of Interest For Testing Of Phase 1 Clinical Samples: Influenza-Specific Memory B Cells And Antibody-Dependent Cell-Mediated Cytotoxicity

2018 - 2018
Completed
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Nano-Bioscience Imaging Facility (NON-ARC Cash)

This project aims to investigate the interactions between nano-engineered materials and biological systems through the use of cutting-edge i..

2018 - 2018
Completed
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Nano-Bioscience Imaging Facility (ARC Cash)

This project aims to investigate the interactions between nano-engineered materials and biological systems through the use of cutting-edge i..

2018 - 2018
Completed
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Mucosal Human Immunodeficiency Virus Vaccine Late Pre-Clinical Evaluation

Despite many candidate vaccines entering clinical development for protection against HIV, none has yet been successful. This proposal centre..

2018 - 2019
Completed
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Improved Hiv And Influenza Vaccines

This fellowship is to support Professor Stephen Kent in generating new advances in vaccines to prevent HIV (the cause of AIDS) and Influenza..

2018 - 2022
Active
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Single Cell Mass Cytometer Research Initiatives Fund Collaborative Equipment Grant

2017 - 2018
Completed
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Antibodies For Broad Protection Against Influenza B (Ibv)

2017 - 2018
Completed
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Antibodies For Broad Protection Against Influenza B (Ibv)

2017 - 2018
Completed
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Broad Antibody Protection Against Hiv-1 In Macaques

2016 - 2017
Completed
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European Aids Vaccine Initiative 2020

A vaccine to prevent AIDS is urgently needed. The European Union recently awarded over 20 million euros to a European consortium, called EAV..

2016 - 2020
Active
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Functional Antibodies In The Control Of Mycobacterium Tuberculosis

2016 - 2016
Completed
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European Aids Vaccine Initiative 2020

A vaccine to prevent AIDS is urgently needed. The European Union recently awarded over 20 million euros to a European consortium, called EAV..

2016 - 2020
Active
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Pre-Clinical Evaluation Of A Novel Hiv-1 Vaccine Strategy

2016 - 2016
Completed
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Antibody Prevention And Treatment Of Hiv

This project will assess new ways to protect against HIV infection and treat HIV infection using potent antibody therapies. This will help u..

2016 - 2019
Completed
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Pre-Clinical Evaluation Of A Novel Hiv-1 Vaccine Strategy

Recently, we have designed two mucosal HIV vaccine strategies that temporary block hormone-like molecules IL-4/IL-13 at the vaccination site..

2015 - 2016
Completed
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Antibody Protection And Therapy For Hiv

2015 - 2016
Completed
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ARC Centre Of Excellence In Convergent Bio–Nano Science And Technology

The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and cont..

2014 - 2021
Active
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ARC Centre Of Excellence In Convergent Bio–Nano Science And Technology

The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and cont..

2014 - 2021
Active
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ARC Centre Of Excellence In Convergent Bio–Nano Science And Technology

2014 - 2021
Active
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ARC Centre Of Excellence In Convergent Bio–Nano Science And Technology

The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and cont..

2014 - 2021
Active
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ARC Centre Of Excellence In Convergent Bio–Nano Science And Technology

The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and cont..

2014 - 2021
Active
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ARC Centre Of Excellence In Convergent Bio–Nano Science And Technology

2014 - 2021
Active
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ARC Centre Of Excellence In Convergent Bio–Nano Science And Technology

2014 - 2021
Active
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ARC Centre Of Excellence In Convergent Bio–Nano Science And Technology

2014 - 2021
Active
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Hiv Latency, Pathogenesis And Immunity

The development of cures, vaccines and better treatments for HIV/AIDS is an urgent global health priority. This team of seven groups in Sydn..

2014 - 2018
Completed
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Hiv Latency Pathogenesis And Immunity

The development of cures, vaccines and better treatments for HIV/AIDS is an urgent global health priority. This team of seven groups in Sydn..

2014 - 2018
Completed
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Hiv Latency Pathogenesis And Immunity

The development of cures, vaccines and better treatments for HIV/AIDS is an urgent global health priority. This team of seven groups in Sydn..

2014 - 2018
Completed
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Hiv Latency Pathogenesis And Immunity

The development of cures, vaccines and better treatments for HIV/AIDS is an urgent global health priority. This team of seven groups in Sydn..

2014 - 2018
Completed
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Antibody-Dependent Cellular Cytotoxicity (Adcc): A New Frontier In Vaccine Research

2013 - 2016
Completed
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Isolation Of Peptide-Specific Antibodies That Mediate The Killing Of Hiv-Infected Cells

2013 - 2014
Completed
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Antibody Protection Against Cell-Associated Hiv

2013 - 2014
Completed
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Antibody-Dependent Cellular Cytotoxicity Based Immunity To Influenza

Pandemic influenza causes widespread disease, death and panic. Producing vaccines to new strains takes time. There is a need to produce vacc..

2013 - 2015
Completed
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Research Fellowship To Study Hiv Vaccines

I am an infectious diseases physician and virologist/immunologist focused on developing and testing vaccines against the AIDS virus. I inten..

2013 - 2017
Completed
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Biomaterials Characterisation Facility

The convergence of nanotechnology and biotechnology offers new opportunities to prepare nanoengineered materials for applications in biomedi..

2012 - 2013
Completed
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An Advanced Flow Cytometry Facility For The Peter Doherty Institute

The establishment of a flow cytometry facility in the new Peter Doherty Institute for Infection and Immunity will enhance capacity to invest..

2011 - 2012
Completed
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Development Of Purified Antibodies That Kill Virus Infected Cells

This proposal will develop panels of purified and monoclonal antibodies that kill virus infected cells. These antibodies may show efficacy i..

2011 - 2014
Completed
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Development Of Purified Antibodies That Kill Virus Infected Cells

This proposal will develop panels of purified and monoclonal antibodies that kill virus infected cells. These antibodies may show efficacy i..

2011 - 2014
Completed
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Hiv Vaccines

2011 - 2013
Completed
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Role Of Hiv-Specific Adcc Activity In Progression Of Hiv-1 In Humans

2010 - 2012
Completed
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Comparison Of Hiv Vaccines

A HIV vaccine remains elusive. Although killer T cell immunity can provide partial protection from HIV disease, we don't know the best type ..

2010 - 2012
Completed
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Advanced Nanobiomaterials Imaging Facility

The convergence of nanotechnology with biotechnology offers unprecedented opportunities to prepare nanomaterials with defined structure and ..

2009
Active
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Hiv & Hcv Vaccines And Immunopathogenesis - Support Funding

The development of vaccines and better treatments for HIV-AIDS and Hepatitis C are urgent global health priorities. This Program will undert..

2009 - 2013
Completed
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The Dynamics Of Latency In Chronic Viral Infection

Although many acute infections can now be controlled, we still suffer from a large number of chronic infections such as HIV or herpes that c..

2009 - 2011
Completed
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Hiv & Hcv Vaccines And Immunopathogenesis

The development of vaccines and better treatments for HIV-AIDS and Hepatitis C are urgent global health priorities. This Program will undert..

2009 - 2013
Completed
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Vaccine For Hiv Using Novel Muscosal Vector And Adjuvant

2009 - 2011
Completed
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Whole Inactivated Siv Pulsed Blood Study In Monkeys

2008 - 2008
Completed
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NHMRC Research Fellowship

Prevention and immunity aginst infectious diseases including HIV-AIDS

2008 - 2012
Completed
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Establishment Of The Hiv Reservoir During Acute Infection

2007 - 2008
Completed
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The Cost And Benefit Of Immune Escape Mutation In Hiv

The HIV pandemic is a global emergency. The overall goal of this grant proposal is to elucidate the requirements for protective immunity to ..

2007 - 2009
Completed
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Therapeutic Vaccines To Protect Against Drug Resistant Hiv

2006 - 2008
Completed
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Immune Responses Targeting Enfuvitide Sensitive And Resistant Viruses

2006 - 2007
Completed
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Dna And Avipox Vaccines For Hiv

nan

2002 - 2005
Completed
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Research Fellowship

nan

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Opal Immunotherapy For Aids

Chronic infections and cancers are major causes of global disease burden. Harnessing the immune system to combat these diseases has proven d..

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Escape And Reversion Of Critical Immune Responses: Insights Into Effective Immunity To Hiv

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Efficacy Studies Of Opal Vaccine Technology

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Mta - Comparative Study Of Fcr-Mediated Antibody Effector Assays For Hiv-1 (Material: Pbmc Samples)

Completed
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Hiv Vaccine Antibodies

Completed
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Nanomaterials Optical Characterisation Facility

Nanotechnology is expected to revolutionize a wide variety of fields, from medicine to agriculture, communications and electronics. However,..

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Safety Studies Of Opal Vaccine Technology

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Hiv Infection: Immunobiology And Vaccine Design

This program application seeks to draw on the skills of a world leading group of Australian researchers to bring novel HIV vaccine designs t..

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Opal Immunotherapy: Comparing Delivery Of Peptide Vaccines By Whole Blood Vs Pbmc In Macaques

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License Agreement - Opal Immunotherapy: Comparing Delivery Of Peptide Vaccines By Whole Blood Vs Pbmc In Macaques

73

Projects

Project Types

52

Research Grant

15

Research Contracts

6

Internal Research Grant

Scholarly Works

Displaying the 323 most recent scholarly works by Stephen Kent.

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Butyrophilin 2A1 is essential for phosphoantigen reactivity by gamma delta T cells

Marc Rigau, Simone Ostrouska, Thomas S Fulford, Darryl N Johnson, Katherine Woods, Zheng Ruan, Hamish EG McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Nash, Andrew Hammet, Anne M Verhagen, Gino Vairo, et al.

Journal article  |  2020  |  Science

Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) ..

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Low-Fouling Fluoropolymers for Bioconjugation and In Vivo Tracking

Changkui Fu, Bans Demir, Sheilajen Alcantara, Vinod Kumar, Felicity Han, Hannah G Kelly, Xiao Tan, Ye Yu, Weizhi Xu, Jiacheng Zhao, Cheng Zhang, Hui Peng, Cyrille Boyer, Trent M Woodruff, Stephen J Kent, Debra J Searles, Andrew K Whittaker

Journal article  |  2020  |  Angewandte Chemie International Edition

The conjugation of hydrophilic low-fouling polymers to therapeutic molecules and particles is an effective approach to improving t..

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The protective potential of Fc-mediated antibody functions against influenza virus and other viral pathogens.

Hillary A Vanderven, Stephen J Kent

Journal article  |  2020  |  Immunology & Cell Biology

In recent years, there has been a renewed interest in utilising antibody Fc functions to prevent and control viral infections. The..

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An Inflammatory Story: Antibodies in Tuberculosis Comorbidities

Mille R McLean, Lenette L Lu, Stephen J Kent, Amy W Chung

Journal article  |  2019  |  Frontiers in Immunology

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Serum IgA Fc effector functions in infectious disease and cancer.

Samantha K Davis, Kevin J Selva, Stephen J Kent, Amy W Chung

Journal article  |  2019  |  Immunology & Cell Biology

Immunoglobulin A (IgA) is the most abundant antibody isotype present at mucosal surfaces and the second most abundant in human ser..

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Impact of HIV-1 viremia or sexually transmitted infection on semen-derived anti-HIV-1 antibodies and the immunosuppressive capacity of seminal plasma

Kevin J Selva, Benjamin R Bavinton, Andrew E Grulich, Marzena Pazgier, Anthony D Kelleher, Stephen J Kent, Matthew S Parsons

Journal article  |  2019  |  European Journal of Immunology

Semen from HIV-1-infected men contains anti-HIV-1 antibodies and immunosuppressive factor(s). We assessed if suppression of viremi..

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Differential Roles of Plasma Protein Corona on Immune Cell Association and Cytokine Secretion of Oligomeric and Fibrillar Beta-Amyloid

Ava Faridi, Wen Yang, Hannah Gabrielle Kelly, Chuanyu Wang, Pouya Faridi, Anthony Wayne Purcell, Thomas P Davis, Pengyu Chen, Stephen J Kent, Pu Chun Ke

Journal article  |  2019  |  Biomacromolecules

Alzheimer's disease (AD) is a primary neurological disease with no effective cure. A hallmark of AD is the presence of intracellul..

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Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcg Receptors: Implications for Measuring Fc Dependent Antibody Functions

Ester Lopez, Nichollas E Scott, Bruce D Wines, P Mark Hogarth, Adam K Wheatley, Stephen J Kent, Amy W Chung

Journal article  |  2019  |  Frontiers in Immunology

Evaluating the biophysical and functional nature of IgG is key to defining correlates of protection in infectious disease, and aut..

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Improving immunological insights into the ferret model of human viral infectious disease

Julius Wong, Daniel Layton, Adam K Wheatley, Stephen J Kent

Journal article  |  2019  |  Influenza and Other Respiratory Viruses

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Characterization of Key Bio-Nano Interactions between Organosilica Nanoparticles and Candida albicans

Vidhishri Kesarwani, Hannah G Kelly, Madhu Shankar, Kye J Robinson, Stephen J Kent, Ana Traven, Simon R Corrie

Journal article  |  2019  |  ACS Applied Materials & Interfaces

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Boosting of Markers of Fc gamma Receptor Function in Anti-HIV Antibodies During Structured Treatment Interruption

Hugh Billings, Bruce D Wines, Wayne B Dyer, Robert J Center, Halina M Trist, Stephen J Kent, P Mark Hogarth

Journal article  |  2019  |  AIDS Research and Human Retroviruses

Anti-HIV envelope antibodies elicit important Fc receptor functions, including FcγRIIIa-mediated NK killing of opsonised infected ..

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Stealth and Targeting of Ligand-Functionalized Poly(ethylene glycol) Particles

Yi Ju, Jiwei Cui, Karen Alt, Stephen Kent, Christoph Hagemeyer, Frank Caruso

Presentation  |  2019

Oral presentation at 10th International Nanomedicine Conference

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Short Communication: Effect of Seminal Plasma on Functions of Monocytes and Granulocytes

Kevin J Selva, Jennifer A Juno, Matthew J Worley, Amy W Chung, Gilda Tachedjian, Stephen J Kent, Matthew S Parsons

Journal article  |  2019  |  AIDS Research and Human Retroviruses

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Moving the HIV vaccine field forward: concepts of protective immunity

Stephen J Kent, Miles P Davenport

Journal article  |  2019  |  The Lancet HIV

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Modulation of the CCR5 Receptor/Ligand Axis by Seminal Plasma and the Utility of In Vitro versus In Vivo Models

Jennifer A Juno, Kathleen M Wragg, Anne B Kristensen, Wen Shi Lee, Kevin J Selva, Renee M van der Sluis, Anthony D Kelleher, Benjamin R Bavinton, Andrew E Grulich, Sharon R Lewin, Stephen J Kent, Matthew S Parsons

Journal article  |  2019  |  Journal of Virology

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Link between Low-Fouling and Stealth: A Whole Blood Biomolecular Corona and Cellular Association Analysis on Nanoengineered Particles

Alessia CG Weiss, Hannah G Kelly, Matthew Faria, Quinn A Besford, Adam K Wheatley, Ching-Seng Ang, Edmund J Crampin, Frank Caruso, Stephen J Kent

Journal article  |  2019  |  ACS Nano

Upon exposure to human blood, nanoengineered particles interact with a multitude of plasma components, resulting in the formation ..

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A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface

Sandhya Bangaru, Shanshan Lang, Michael Schotsaert, Hillary A Vanderven, Xueyong Zhu, Nurgun Kose, Robin Bombardi, Jessica A Finn, Stephen J Kent, Pavlo Gilchuk, Iuliia Gilchuk, Hannah L Turner, Adolfo Garcia-Sastre, Sheng Li, Andrew B Ward, Ian A Wilson, James E Crowe

Journal article  |  2019  |  Cell

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Knowns and Unknowns of Assaying Antibody-Dependent Cell-Mediated Cytotoxicity Against HIV-1

George K Lewis, Margaret E Ackerman, Gabriella Scarlatti, Christiane Moog, Marjorie Robert-Guroff, Stephen J Kent, Julie Overbaugh, R Keith Reeves, Guido Ferrari, Bargavi Thyagarajan

Journal article  |  2019  |  Frontiers in Immunology

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CD4-and Time-Dependent Susceptibility of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity

Wen Shi Lee, Jeremie Prevost, Jonathan Richard, Renee M van der Sluis, Sharon R Lewin, Marzena Pazgier, Andres Finzi, Matthew S Parsons, Stephen J Kent

Journal article  |  2019  |  Journal of Virology

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Modulating Targeting of Poly(ethylene glycol) Particles to Tumor Cells Using Bispecific Antibodies

Jiwei Cui, Yi Ju, Zachary H Houston, Joshua J Class, Nicholas L Fletcher, Sheilajen Alcantara, Qiong Dai, Christopher B Howard, Stephen M Mahler, Adam K Wheatley, Robert De Rose, Paul T Brannon, Brett M Paterson, Paul S Donnelly, Kristoferj Thurecht, Frank Caruso, Stephen J Kent

Journal article  |  2019  |  Advanced Healthcare Materials

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Mucosal and systemic SIV-specific cytotoxic CD4( ) T cell hierarchy in protection following intranasal/intramuscular recombinant pox-viral vaccination of pigtail macaques

Mayank Khanna, Ronald J Jackson, Sheilajen Alcantara, Thakshila H Amarasena, Zheyi Li, Anthony D Kelleher, Stephen J Kent, Charani Ranasinghe

Journal article  |  2019  |  Scientific Reports

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Identification of murine antigen-specific T follicular helper cells using an activation-induced marker assay

Wenbo Jiang, Kathleen M Wragg, Hyon-Xhi Tan, Hannah G Kelly, Adam K Wheatley, Stephen J Kent, Jennifer A Juno

Journal article  |  2019  |  Journal of Immunological Methods

Protective antibody (Ab) responses induced by natural infection or vaccination play a central role in defense against invasive pat..

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MAIT Cells Upregulate alpha 4 beta 7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques

Jennifer A Juno, Kathleen M Wragg, Thakshila Amarasena, Bronwyn S Meehan, Jeffrey YW Mak, Ligong Liu, David P Fairlie, James McCluskey, Sidonia BG Eckle, Stephen J Kent

Journal article  |  2019  |  The Journal of Immunology

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Inducible Bronchus-Associated Lymphoid Tissues (iBALT) Serve as Sites of B Cell Selection and Maturation Following Influenza Infection in Mice

Hyon-Xhi Tan, Robyn Esterbauer, Hillary A Vanderven, Jennifer A Juno, Stephen J Kent, Adam K Wheatley

Journal article  |  2019  |  Frontiers in Immunology

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Immunological basis for enhanced immunity of nanoparticle vaccines

Hannah G Kelly, Stephen J Kent, Adam K Wheatley

Journal article  |  2019  |  Expert Review of Vaccines

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Perturbation of mucosal-associated invariant T cells and iNKT cells in HIV infection

Jennifer A Juno, Chansavath Phetsouphanh, Paul Klenerman, Stephen J Kent

Journal article  |  2019  |  Current Opinion in HIV and AIDS

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Role of IgG3 in Infectious Diseases

Timon Damelang, Stephen J Rogerson, Stephen J Kent, Amy W Chung

Journal article  |  2019  |  Trends in Immunology

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Influenza Virus Infection Enhances Antibody-Mediated NK Cell Functions via Type I Interferon-Dependent Pathways

Sinthujan Jegaskanda, Hillary A Vanderven, Hyon-Xhi Tan, Sheilajen Alcantara, Kathleen M Wragg, Matthew S Parsons, Amy W Chung, Jennifer A Juno, Stephen J Kent

Journal article  |  2019  |  Journal of Virology

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Two Families of Env Antibodies Efficiently Engage Fc-Gamma Receptors and Eliminate HIV-1-Infected Cells

Sai Priya Anand, Jeremie Prevost, Sophie Baril, Jonathan Richard, Halima Medjahed, Jean-Philippe Chapleau, William D Tolbert, Sharon Kirk, Amos B Smith, Bruce D Wines, Stephen J Kent, P Mark Hogarth, Matthew S Parsons, Marzena Pazgier, Andres Finzi

Journal article  |  2019  |  Journal of Virology

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Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem

Hyon-Xhi Tan, Sinthujan Jegaskanda, Jennifer A Juno, Robyn Esterbauer, Julius Wong, Hannah G Kelly, Yi Liu, Danielle Tilmanis, Aeron C Hurt, Jonathan W Yewdell, Stephen J Kent, Adam K Wheatley

Journal article  |  2019  |  Journal of Clinical Investigation

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Cross-lineage protection by human antibodies binding the influenza B hemagglutinin

Yi Liu, Hyon-Xhi Tan, Marios Koutsakos, Sinthujan Jegaskanda, Robyn Esterbauer, Danielle Tilmanis, Malet Aban, Katherine Kedzierska, Aeron C Hurt, Stephen J Kent, Adam K Wheatley

Journal article  |  2019  |  Nature Communications

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Fc-dependent functions are redundant to efficacy of anti-HIV antibody PGT121 in macaques

Matthew S Parsons, Wen Shi Lee, Anne B Kristensen, Thakshila Amarasena, Georges Khoury, Adam K Wheatley, Arnold Reynaldi, Bruce D Wines, P Mark Hogarth, Miles P Davenport, Stephen J Kent

Journal article  |  2019  |  Journal of Clinical Investigation

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Functional cure of HIV: the scale of the challenge

Miles P Davenport, David S Khoury, Deborah Cromer, Sharon R Lewin, Anthony D Kelleher, Stephen J Kent

Journal article  |  2019  |  Nature Reviews Immunology

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Ageing in patients with chronic HIV infection: impact of hypercoagulation

Stephen J Kent, Charles Flexner

Journal article  |  2018  |  AIDS Research and Therapy

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Anti-Influenza Hyperimmune Immunoglobulin Enhances Fc-Functional Antibody Immunity During Human Influenza Infection

Hillary A Vanderen, Kathleen Wragg, Fernanda Ana-Sosa-Batiz, Anne B Kristensen, Sinthujan Jegaskanda, Adam K Wheatley, Deborah Wentworth, Bruce D Wines, P Mark Hogarth, Steve Rockman, Stephen J Kent

Journal article  |  2018  |  The Journal of Infectious Diseases

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Limited Impact of Fc-dependent Functions on the Efficacy of the Anti-HIV-1 Broadly Neutralizing Antibody PGT121 in Macaques

Matthew Parsons, Wen Shi Lee, Anne Kristensen, Thakshila Amarasena, Georges Khoury, Miles Davenport, Stephen Kent

Conference Proceedings  |  2018  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

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Immunosuppressive Factors Within Seminal Plasma Muzzle Anti-HIV-1 Immune Responses of Granulocytes and Monocytes

Kevin John Selva, Matthew Sidney Parsons, Stephen John Kent

Conference Proceedings  |  2018  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

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Killing a Moving Target: ADCC Against HIV-1-infected Cells in the Process of CD4-downregulation

Wen Shi Lee, Jeremie Prevost, Jonathan Richard, Renee M van der Sluis, Sharon R Lewin, Marzena Pazgier, Andres Finzi, Matthew S Parsons, Stephen J Kent

Conference Proceedings  |  2018  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

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IgA Inhibits HIV-specific Antibody-dependent Neutrophil Phagocytosis

Matthew Worley, Ester Lopez, Anthony Kelleher, Stephen Kent, Amy Chung

Conference Proceedings  |  2018  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

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Vorapaxar for HIV-associated inflammation and coagulopathy (ADVICE): a randomised, double-blind, placebo-controlled trial

Stephen J Kent, Sally Hough, Matthew G Law, Jolie Hutchinson, David van Bockel, Anthony D Kelleher, Marta Catalfamo, Cliff Lane, Jason V Baker, Sean Emery

Journal article  |  2018  |  The Lancet HIV

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Combined Skin and Muscle DNA Priming Provides Enhanced Humoral Responses to an HIV-1 Clade C Envelope Vaccine

Hannah Cheeseman, Suzanne Day, Leon McFarlane, Sue Fleck, Aleisha Miller, Tom Cole, Alethea Cope, Monica Tolazzi, Drew Hannaman, Sven Kratochvil, Paul McKay, Stephen Kent, Amy Chung, Alistar Cook, Gabriella Scarlatti, Behazine Combadiere, Sonya Abraham, Sheena McCormack, David Lewis, Robin Shattock

Conference Proceedings  |  2018  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

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A Lipid/DNA Adjuvant-Inactivated Influenza Virus Vaccine Protects Rhesus Macaques From Uncontrolled Virus Replication After Heterosubtypic Influenza A Virus Challenge

Timothy D Carroll, Sinthujan Jegaskanda, Shannon R Matzinger, Linda Fritts, Michael B McChesney, Stephen J Kent, Jeffery Fairman, Christopher J Miller

Journal article  |  2018  |  The Journal of Infectious Diseases

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Combined Skin and Muscle DNA Priming Provides Enhanced Humoral Responses to a Human Immunodeficency Virus Type 1 Clade C Envelope Vaccine

HM Cheeseman, S Day, LR McFarlane, S Fleck, A Miller, T Cole, N Sousa-Santos, A Cope, D Cizmeci, M Tolazzi, E Hwekwete, D Hannaman, S Kratochvil, PF McKay, AW Chung, SJ Kent, A Cook, G Scarlatti, S Abraham, B Combadiere, et al.

Journal article  |  2018  |  Human Gene Therapy

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The Multifaceted Nature of Immunoglobulin A and Its Complex Role in HIV

Ester Lopez, Robin J Shattock, Stephen J Kent, Amy W Chung

Journal article  |  2018  |  AIDS Research and Human Retroviruses

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Combined Skin and Muscle DNA Priming Provides Enhanced Humoral Responses to a Human Immunodeficency Virus Type 1 Clade C Envelope Vaccine

Hannah Mary Cheeseman, Suzanne Day, Leon Robert McFarlane, Sue Fleck, Aleisha Miller, Tom Cole, Nelson Sousa-Santos, Alethea Cope, Deniz Cizmeci, Monica Tolazzi, Edith Hwekwete, Drew Hannaman, Sven Kratochvil, Paul Francis McKay, Amy W Chung, Stephen J Kent, Adrian Cook, Gabriella Scarlatti, Sonya Abraham, Behazine Combadiere, et al.

Journal article  |  2018  |  Human Gene Therapy

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Minimum information reporting in bio-nano experimental literature

Matthew Faria, Mattias Bjornmalm, Kristofer J Thurecht, Stephen J Kent, Robert G Parton, Maria Kavallaris, Angus PR Johnston, J Justin Gooding, Simon R Corrie, Ben J Boyd, Pall Thordarson, Andrew K Whittaker, Molly M Stevens, Clive A Prestidge, Christopher JH Porter, Wolfgang J Parak, Thomas P Davis, Edmund J Crampin, Frank Caruso

Journal article  |  2018  |  Nature Nanotechnology

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Importance of Fc-mediated functions of anti-HIV-1 broadly neutralizing antibodies

Matthew S Parsons, Amy W Chung, Stephen J Kent

Journal article  |  2018  |  Retrovirology

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The Rare Anaphylaxis-Associated Fc gamma RIIa3 Exhibits Distinct Characteristics From the Canonical Fc gamma RIIa1

Jessica C Anania, Halina M Trist, Catherine S Palmer, Peck Szee Tan, Betty P Kouskousis, Alicia M Chenoweth, Stephen J Kent, Graham A Mackay, Alberta Hoi, Rachel Koelmeyer, Charlotte Slade, Vanessa L Bryant, Philip D Hodgkin, Pei Mun Aui, Menno C van Zelm, Bruce D Wines, P Mark Hogarth

Journal article  |  2018  |  Frontiers in Immunology

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A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA

Sandhya Bangaru, Heng Zhang, Iuliia M Gilchuk, Thomas G Voss, Ryan P Irving, Pavlo Gilchuk, Pranathi Matta, Xueyong Zhu, Shanshan Lang, Travis Nieusma, Juergen A Richt, Randy A Albrecht, Hillary A Vanderven, Robin Bombardi, Stephen J Kent, Andrew B Ward, Ian A Wilson, James E Crowe

Journal article  |  2018  |  Nature Communications

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Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2oxazoline)

Miaoyi Wang, Ove JR Gustafsson, Ghizal Siddiqui, Ibrahim Javed, Hannah G Kelly, Thomas Blin, Hong Yin, Stephen J Kent, Darren J Creek, Kristian Kempe, Pu Chun Ke, Thomas P Davis

Journal article  |  2018  |  Nanoscale

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Contribution of NK Cell Education to both Direct and Anti-HIV-1 Antibody-Dependent NK Cell Functions

Anne B Kristensen, Stephen J Kent, Matthew S Parsons

Journal article  |  2018  |  Journal of Virology

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Neutrophils mediate HIV-specific antibody-dependent phagocytosis and ADCC

Matthew J Worley, Kuangyu Fei, Adam J Lopez-Denman, Anthony D Kelleher, Stephen J Kent, Amy W Chung

Journal article  |  2018  |  Journal of Immunological Methods

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Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics

Sri H Ramarathinam, Stephanie Gras, Sheilajen Alcantara, Amanda WS Yeung, Nicole A Mifsud, Secondo Sonza, Patricia T Illing, Elias N Glaros, Robert J Center, Shane R Thomas, Stephen J Kent, Nicola Ternette, Damian FJ Purcell, Jamie Rossjohn, Anthony W Purcell

Journal article  |  2018  |  PROTEOMICS

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Neutralizing Antibody-Based Prevention of Cell-Associated HIV-1 Infection

Matthew S Parsons, Roger Le Grand, Stephen J Kent

Journal article  |  2018  |  Viruses

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Mucosal-Associated Invariant T Cells Are Depleted and Exhibit Altered Chemokine Receptor Expression and Elevated Granulocyte Macrophage-Colony Stimulating Factor Production During End-Stage Renal Disease

Jennifer A Juno, Jillian LM Waruk, Kathleen M Wragg, Christine Mesa, Carmen Lopez, Joe Bueti, Stephen J Kent, T Blake Ball, Sandra A Kiazyk

Journal article  |  2018  |  Frontiers in Immunology

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HIV Reactivation after Partial Protection by Neutralizing Antibodies

Matthew S Parsons, Deborah Cromer, Miles P Davenport, Stephen J Kent

Journal article  |  2018  |  Trends in Immunology

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The effect of antiretroviral intensification with dolutegravir on residual virus replication in HIV-infected individuals: a randomised, placebo-controlled, double-blind trial

Thomas A Rasmussen, James H McMahon, J Judy Chang, Jennifer Audsley, Ajantha Rhodes, Surekha Tennakoon, Ashanti Dantanarayana, Tim Spelman, Tina Schmidt, Stephen J Kent, Vincent Morcilla, Sarah Palmer, Julian H Elliott, Sharon R Lewin

Journal article  |  2018  |  The Lancet HIV

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Induction of vaginal-resident HIV-specific CD8 T cells with mucosal prime-boost immunization

H-X Tan, AK Wheatley, R Esterbauer, S Jegaskanda, JJ Glass, D Masopust, R De Rose, SJ Kent

Journal article  |  2018  |  Mucosal Immunology

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2017 international meeting of the Global Virus Network

Mike Catton, Glenda Gray, Diane Griffin, Hideki Hasegawa, Stephen J Kent, Jason Mackenzie, Edward McSweegan, Natalia Mercer, Linfa Wang

Journal article  |  2018  |  Antiviral Research

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Anti-HIV-1 antibody-dependent cellular cytotoxicity: is there more to antibodies than neutralization?

Wen Shi Lee, Stephen J Kent

Journal article  |  2018  |  Current Opinion in HIV and AIDS

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Circulating T-FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

Marios Koutsakos, Adam K Wheatley, Liyen Loh, E Bridie Clemens, Sneha Sant, Simone Nussing, Annette Fox, Amy W Chung, Karen L Laurie, Aeron C Hurt, Steve Rockman, Martha Lappas, Thomas Loudovaris, Stuart I Mannering, Glen P Westall, Michael Elliot, Stuart G Tangye, Linda M Wakim, Stephen J Kent, Thi HO Nguyen, et al.

Journal article  |  2018  |  Science Translational Medicine

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Influence of charge on hemocompatibility and immunoreactivity of polymeric nanoparticles

L Chen, JJ Glass, R De Rose, C Sperling, SJ Kent, ZH Houston, NL Fletcher, BE Rolfe, KJ Thurecht

Journal article  |  2018  |  ACS Applied Bio Materials

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Antibody-Dependent Cellular Cytotoxicity Responses to Seasonal Influenza Vaccination in Older Adults

Hillary A Vanderven, Sinthujan Jegaskanda, Bruce D Wines, P Mark Hogarth, Sarina Carmuglia, Steven Rockman, Amy W Chung, Stephen J Kent

Journal article  |  2018  |  The Journal of Infectious Diseases

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Immunoglobulin G1 Allotype Influences Antibody Subclass Distribution in Response to HIV gp140 Vaccination

Sven Kratochvil, Paul F McKay, Amy W Chung, Stephen J Kent, Jill Gilmore, Robin J Shattock

Journal article  |  2017  |  Frontiers in Immunology

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A Role for Fc-Mediated Humoral Immunity in Reducing HIV Transmission Rates between HIV Serodiscordant Heterosexual Couples

Stephen J Kent, Amy W Chung

Journal article  |  2017  |  EBioMedicine

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Modeling of Antilatency Treatment in HIV: What Is the Optimal Duration of Antiretroviral Therapy-Free HIV Remission?

Deborah Cromer, Mykola Pinkevych, Thomas A Rasmussen, Sharon R Lewin, Stephen J Kent, Miles P Davenport

Journal article  |  2017  |  Journal of Virology

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Antibody-dependent phagocytosis (ADP) responses following trivalent inactivated influenza vaccination of younger and older adults

Fernanda Ana-Sosa-Batiz, Angus PR Johnston, P Mark Hogarth, Bruce D Wines, Ian Barr, Adam K Wheatley, Stephen J Kent

Journal article  |  2017  |  Vaccine

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Templated Polymer Replica Nanoparticles to Facilitate Assessment of Material-Dependent Pharmacokinetics and Biodistribution

Danzi Song, Jiwei Cui, Huanli Sun, Tri-Hung Nguyen, Sheilajen Alcantara, Robert De Rose, Stephen J Kent, Christopher JH Porter, Frank Caruso

Journal article  |  2017  |  ACS Applied Materials & Interfaces

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HIV-1 Env- and Vpu-Specific Antibody-Dependent Cellular Cytotoxicity Responses Associated with Elite Control of HIV

Vijaya Madhavi, Bruce D Wines, Janaki Amin, Sean Emery, Ester Lopez, Anthony Kelleher, Rob J Center, P Mark Hogarth, Amy W Chung, Stephen J Kent, Ivan Stratov

Journal article  |  2017  |  Journal of Virology

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Impact of alemtuzumab on HIV persistence in an HIV-infected individual on antiretroviral therapy with Sezary syndrome

Thomas A Rasmussen, James McMahon, J Judy Chang, Jori Symons, Michael Roche, Ashanti Dantanarayana, Afam Okoye, Bonnie Hiener, Sarah Palmer, Wen Shi Lee, Stephen J Kent, Carrie Van der Weyden, H Miles Prince, Paul U Cameron, Sharon R Lewin

Journal article  |  2017  |  AIDS

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Partial efficacy of a broadly neutralizing antibody against cell-associated SHIV infection

Matthew S Parsons, Sarah B Lloyd, Wen Shi Lee, Anne B Kristensen, Thakshila Amarasena, Rob J Center, Brandon F Keele, Jeffrey D Lifson, Celia C LaBranche, David Montefiori, Bruce D Wines, Mark Hogarth, Kristine M Swiderek, Vanessa Venturi, Miles P Davenport, Stephen J Kent

Journal article  |  2017  |  SCIENCE TRANSLATIONAL MEDICINE

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Anti-HIV-1 ADCC Antibodies following Latency Reversal and Treatment Interruption

Wen Shi Lee, Anne B Kristensen, Thomas A Rasmussen, Martin Tolstrup, Lars Ostergaard, Ole S Sogaard, Bruce D Wines, P Mark Hogarth, Arnold Reynaldi, Miles P Davenport, Sean Emery, Janaki Amin, David A Cooper, Virginia L Kan, Julie Fox, Henning Gruell, Matthew S Parsons, Stephen J Kent

Journal article  |  2017  |  JOURNAL OF VIROLOGY

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Dimeric Fc gamma Receptor Enzyme-Linked Immunosorbent Assay To Study HIV-Specific Antibodies: A New Look into Breadth of Fc gamma Receptor Antibodies Induced by the RV144 Vaccine Trial

Milla R McLean, Vijaya Madhavi, Bruce D Wines, P Mark Hogarth, Amy W Chung, Stephen J Kent

Journal article  |  2017  |  The Journal of Immunology

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Fc functional antibodies in humans with severe H7N9 and seasonal influenza

Hillary A Vanderven, Lu Liu, Fernanda Ana-Sosa-Batiz, Thi HO Nguyen, Yanmin Wan, Bruce Wines, P Mark Hogarth, Danielle Tilmanis, Arnold Reynaldi, Matthew S Parsons, Aeron C Hurt, Miles P Davenport, Tom Kotsimbos, Allen C Cheng, Katherine Kedzierska, Xiaoyan Zhang, Jianqing Xu, Stephen J Kent

Journal article  |  2017  |  JCI Insight

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Effect of Combination Antiretroviral Therapy on HIV-1-specific Antibody-Dependent Cellular Cytotoxicity Responses in Subtype B- and Subtype C-Infected Cohorts

Vijaya Madhavi, Archana Kulkarni, Ashwini Shete, Wen S Lee, Milla R Mclean, Anne B Kristensen, Manisha Ghate, Bruce D Wines, Phillip M Hogarth, Matthew S Parsons, Anthony Kelleher, David A Cooper, Janaki Amin, Sean Emery, Madhuri Thakar, Stephen J Kent

Journal article  |  2017  |  JAIDS Journal of Acquired Immune Deficiency Syndromes

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Charge Has a Marked Influence on Hyperbranched Polymer Nanoparticle Association in Whole Human Blood

Joshua J Glass, Liyu Chen, Sheilajen Alcantara, Edmund J Crampin, Kristofer J Thurecht, Robert De Rose, Stephen J Kent

Journal article  |  2017  |  ACS Macro Letters

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A Phase 1 Human Immunodeficiency Virus Vaccine Trial for Cross-Profiling the Kinetics of Serum and Mucosal Antibody Responses to CN54gp140 Modulated by Two Homologous Prime-Boost Vaccine Regimens

Sven Kratochvil, Paul F McKay, Jakub T Kopycinski, Cynthia Bishop, Peter John Hayes, Luke Muir, Christopher L Pinder, Deniz Cizmeci, Deborah King, Yoann Aldon, Bruce D Wines, P Mark Hogarth, Amy W Chung, Stephen J Kent, Kathrin Held, Christof Geldmacher, Len Dally, Nelson S Santos, Tom Cole, Jill Gilmour, et al.

Journal article  |  2017  |  Frontiers in Immunology

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Divergent expression of CXCR5 and CCR5 on CD4( ) T Cells and the Paradoxical Accumulation of T Follicular Helper Cells during Hiv infection

John Zaunders, Yin Xu, Stephen J Kent, Kersten K Koelsch, Anthony D Kelleher

Journal article  |  2017  |  Frontiers in Immunology

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Interferon epsilon and HIV Expanding role for type I Interferons in restricting HIV growth

Stephen J Kent, Anthony D Kelleher

Journal article  |  2017  |  Immunology and Cell Biology

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Intravenous Immunoglobulin Protects Against Severe Pandemic Influenza Infection

Steven Rockman, Sue Lowther, Sarina Camuglia, Kirsten Vandenberg, Shirley Taylor, Lou Fabri, Sylvia Miescher, Martin Pearse, Deborah Middleton, Stephen J Kent, Darry Maher

Journal article  |  2017  |  EBioMedicine

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Relationship between Measures of HIV Reactivation and Decline of the Latent Reservoir under Latency-Reversing Agents

Janka Petravic, Thomas A Rasmussen, Sharon R Lewin, Stephen J Kent, Miles P Davenport

Journal article  |  2017  |  Journal of Virology

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HIV-1 and SIV Predominantly Use CCR5 Expressed on a Precursor Population to Establish Infection in T Follicular Helper Cells

Yin Xu, Chansavath Phetsouphanh, Kazuo Suzuki, Anu Aggrawal, Stephanie Graff-Dubois, Michael Roche, Michelle Bailey, Sheilajen Alcantara, Kieran Cashin, Rahuram Sivasubramaniam, Kersten K Koelsch, Brigitte Autran, Richard Harvey, Paul R Gorry, Arnaud Moris, David A Cooper, Stuart Turville, Stephen J Kent, Anthony D Kelleher, John Zaunders

Journal article  |  2017  |  Frontiers in Immunology

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Thiol-Reactive Star Polymers Display Enhanced Association with Distinct Human Blood Components

Joshua J Glass, Yang Li, Robert De Rose, Angus PR Johnston, Ewa I Czuba, Song Yang Khor, John F Quinn, Michael R Whittaker, Thomas P Davis, Stephen J Kent

Journal article  |  2017  |  ACS Applied Materials & Interfaces

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Antibody-dependent cellular cytotoxicity and influenza virus

Hillary A Vanderven, Sinthujan Jegaskanda, Adam K Wheatley, Stephen J Kent

Journal article  |  2017  |  Current Opinion in Virology

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Modulation of innate and adaptive cellular immunity relevant to HIV-1 vaccine design by seminal plasma

Kevin J Selva, Stephen J Kent, Matthew S Parsons

Journal article  |  2017  |  AIDS

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Cytotoxic CD4 T Cells-Friend or Foe during Viral Infection?

Jennifer A Juno, David van Bockel, Stephen J Kent, Anthony D Kelleher, John J Zaunders, C Mee Ling Munier

Journal article  |  2017  |  Frontiers in Immunology

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Indian Long-term Non-Progressors Show Broad ADCC Responses with Preferential Recognition of V3 Region of Envelope and a Region from Tat Protein

Archana Kulkarni, Swarali Kurle, Ashwini Shete, Manisha Ghate, Sheela Godbole, Vijaya Madhavi, Stephen J Kent, Ramesh Paranjape, Madhuri Thakar

Journal article  |  2017  |  Frontiers in Immunology

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Exploration of broadly neutralizing antibody fragments produced in bacteria for the control of HIV

Sarah B Lloyd, Keith P Niven, Ben R Kiefel, David C Montefiori, Arnold Reynaldi, Miles P Davenport, Stephen J Kent, Wendy R Winnall

Journal article  |  2017  |  Human Vaccines & Immunotherapeutics

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Fc or not Fc; that is the question: Antibody Fc-receptor interactions are key to universal influenza vaccine design

Sinthujan Jegaskanda, Hillary A Vanderven, Adam K Wheatley, Stephen J Kent

Journal article  |  2017  |  Human Vaccines & Immunotherapeutics

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Immunological Principles Guiding the Rational Design of Particles for Vaccine Delivery

Katelyn T Gause, Adam K Wheatley, Jiwei Cui, Yan Yan, Stephen J Kent, Frank Caruso

Journal article  |  2017  |  ACS Nano

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Antibody Functional Assays as Measures of Fc Receptor-Mediated Immunity to HIV - New Technologies and their Impact on the HIV Vaccine Field

Bruce D Wines, Hugh Billings, Milla R Mclean, Stephen J Kent, P Mark Hogarth

Journal article  |  2017  |  Current HIV Research

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HIV vaccines moving forward

Stephen J Kent, Jerome H Kim

Journal article  |  2016  |  Current Opinion in HIV and AIDS

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The primary immune response to Vaccinia virus vaccination includes cells with a distinct cytotoxic effector CD4 T-cell phenotype

C Mee Ling Munier, David van Bockel, Michelle Bailey, Susanna Ip, Yin Xu, Sheilajen Alcantara, Sue Min Liu, Gareth Denyer, Warren Kaplan, Kazuo Suzuki, Nathan Croft, Anthony Purcell, David Tscharke, David A Cooper, Stephen J Kent, John J Zaunders, Anthony D Kelleher

Journal article  |  2016  |  Vaccine

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Twist in the Tail: Escape from HIV Neutralising Antibodies at a Single Site Confers Broad Susceptibility to Others

Adam K Wheatley, Stephen J Kent

Journal article  |  2016  |  EBioMedicine

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NKG2D Acts as a Co-Receptor for Natural Killer Cell-Mediated Anti-HIV-1 Antibody-Dependent Cellular Cytotoxicity

Matthew S Parsons, Jonathan Richard, Wen Shi Lee, Hillary Vanderven, Michael D Grant, Andres Finzi, Stephen J Kent

Journal article  |  2016  |  AIDS Research and Human Retroviruses

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Dimeric Fc gamma R Ectodomains as Probes of the Fc Receptor Function of Anti-Influenza Virus IgG

Bruce D Wines, Hillary A Vanderven, Sandra E Esparon, Anne B Kristensen, Stephen J Kent, P Mark Hogarth

Journal article  |  2016  |  The Journal of Immunology

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Central nervous system-specific consequences of simian immunodeficiency virus Gag escape from major histocompatibility complex class I-mediated control

Sarah E Beck, Suzanne E Queen, Raphael Viscidi, Darius Johnson, Stephen J Kent, Robert J Adams, Patrick M Tarwater, Joseph L Mankowski

Journal article  |  2016  |  Journal of NeuroVirology

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Modeling of Experimental Data Supports HIV Reactivation from Latency after Treatment Interruption on Average Once Every 5-8 Days

Mykola Pinkevych, Stephen J Kent, Martin Tolstrup, Sharon R Lewin, David A Cooper, Ole S Sogaard, Thomas A Rasmussen, Anthony D Kelleher, Deborah Cromer, Miles P Davenport

Journal article  |  2016  |  PLOS Pathogens

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Antibody Responses with Fc-Mediated Functions after Vaccination of HIV-Infected Subjects with Trivalent Influenza Vaccine

Anne B Kristensen, William N Lay, Fernanda Ana-Sosa-Batiz, Hillary A Vanderven, Vijaya Madhavi, Karen L Laurie, Louise Carolan, Bruce D Wines, Mark Hogarth, Adam K Wheatley, Stephen J Kent

Journal article  |  2016  |  Journal of Virology

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What Lies Beneath: Antibody Dependent Natural Killer Cell Activation by Antibodies to Internal Influenza Virus Proteins

Hillary A Vanderven, Fernanda Ana-Sosa-Batiz, Sinthujan Jegaskanda, Steven Rockman, Karen Laurie, Ian Barr, Weisan Chen, Bruce Wines, P Mark Hogarth, Teresa Lambe, Sarah C Gilbert, Matthew S Parsons, Stephen J Kent

Journal article  |  2016  |  EBioMedicine

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HIV-dependent depletion of influenza-specific memory B cells impacts B cell responsiveness to seasonal influenza immunisation

Adam K Wheatley, Anne B Kristensen, William N Lay, Stephen J Kent

Journal article  |  2016  |  Scientific Reports

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High fidelity simian immunodeficiency virus reverse transcriptase mutants have impaired replication in vitro and in vivo

Sarah B Lloyd, Marit Lichtfuss, Thakshila H Amarasena, Sheilajen Alcantara, Robert De Rose, Gilda Tachedjian, Hamid Alinejad-Rokny, Vanessa Venturi, Miles P Davenport, Wendy R Winnall, Stephen J Kent

Journal article  |  2016  |  Virology

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Influenza-Specific Antibody-Dependent Phagocytosis

Fernanda Ana-Sosa-Batiz, Hillary Vanderven, Sinthujan Jegaskanda, Angus Johnston, Steven Rockman, Karen Laurie, Ian Barr, Patrick Reading, Marit Lichtfuss, Stephen J Kent

Journal article  |  2016  |  PLOS ONE

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Functional advantage of educated KIR2DL1( ) natural killer cells for anti-HIV-1 antibody-dependent activation

SL Gooneratne, RJ Center, SJ Kent, MS Parsons

Journal article  |  2016  |  Clinical & Experimental Immunology

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Recombinant influenza virus expressing HIV-1 p24 capsid protein induces mucosal HIV-specific CD8 T-cell responses

Hyon-Xhi Tan, Brad P Gilbertson, Sinthujan Jegaskanda, Sheilajen Alcantara, Thakshila Amarasena, John Stambas, Julie L McAuley, Stephen J Kent, Robert De Rose

Journal article  |  2016  |  Vaccine

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Antibody-Dependent Cellular Cytotoxicity against Reactivated HIV-1-Infected Cells

Wen Shi Lee, Jonathan Richard, Marit Lichtfuss, Amos B Smith, Jongwoo Park, Joel R Courter, Bruno N Melillo, Joseph G Sodroski, Daniel E Kaufmann, Andres Finzi, Matthew S Parsons, Stephen J Kent

Journal article  |  2016  |  Journal of Virology

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Seminal Plasma Anti-HIV Antibodies Trigger Antibody-dependent Cellular Cytotoxicity: Implications for HIV Transmission

Matthew S Parsons, Vijaya Madhavi, Fernanda Ana-Sosa-Batiz, Rob J Center, Kim M Wilson, Torsak Bunupuradah, Kiat Ruxrungtham, Stephen J Kent

Journal article  |  2016  |  JAIDS Journal of Acquired Immune Deficiency Syndromes

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Human immune cell targeting of protein nanoparticles - caveospheres

Joshua J Glass, Daniel Yuen, James Rae, Angus PR Johnston, Robert G Parton, Stephen J Kent, Robert De Rose

Journal article  |  2016  |  Nanoscale

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Tuning the properties of pH responsive nanoparticles to control cellular interactions in vitro and ex vivo

SK Mann, A Dufour, JJ Glass, R De Rose, SJ Kent, GK Such, APR Johnston

Journal article  |  2016  |  Polymer Chemistry

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Contemporary HIV Vaccines: Tissue Resident T-Cells and Strategies to Prevent Mucosal Infection

Hyon-Xhi Tan, Stephen J Kent, Robert De Rose

Journal article  |  2016  |  Current Topics in Medicinal Chemistry

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Enhancing dendritic cell activation and HIV vaccine effectiveness through nanoparticle vaccination

Joshua J Glass, Stephen J Kent, Robert De Rose

Journal article  |  2016  |  Expert Review of Vaccines

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Paradox of Protection: Preferential Recognition of CD4-induced Epitopes by Anti-HIV-1 ADCC Antibodies

Matthew S Parsons, Stephen J Kent

Journal article  |  2015  |  EBioMedicine

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Prospects for antibody-based universal influenza vaccines in the context of widespread pre-existing immunity

Adam Kenneth Wheatley, Stephen John Kent

Journal article  |  2015  |  Expert Review of Vaccines

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Phenotypical and functional profiles of natural killer cells exhibiting matrix metalloproteinase-mediated CD16 cleavage after anti-HIV antibody-dependent activation

C-C Tang, G Isitman, J Bruneau, C Tremblay, NF Bernard, SJ Kent, MS Parsons

Journal article  |  2015  |  Clinical & Experimental Immunology

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HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days-Implications for HIV Remission

Mykola Pinkevych, Deborah Cromer, Martin Tolstrup, Andrew J Grimm, David A Cooper, Sharon R Lewin, Ole S Sogaard, Thomas A Rasmussen, Stephen J Kent, Anthony D Kelleher, Miles P Davenport

Journal article  |  2015  |  PLOS Pathogens

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Can HIV-1-specific ADCC assist the clearance of reactivated latently infected cells?

Wen Shi Lee, Matthew Sidney Parsons, Stephen John Kent, Marit Lichtfuss

Journal article  |  2015  |  Frontiers in Immunology

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Epitope-Specific CD8( ) T Cell Kinetics Rather than Viral Variability Determine the Timing of Immune Escape in Simian Immunodeficiency Virus Infection

Alexey P Martyushev, Janka Petravic, Andrew J Grimm, Hamid Alinejad-Rokny, Shayarana L Gooneratne, Jeanette C Reece, Deborah Cromer, Stephen J Kent, Miles P Davenport

Journal article  |  2015  |  The Journal of Immunology

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Simian immunodeficiency virus infection and immune responses in the pig-tailed macaque testis

Wendy R Winnall, Sarah B Lloyd, Robert De Rose, Sheilajen Alcantara, Thakshila H Amarasena, Mark P Hedger, Jane E Girling, Stephen J Kent

Journal article  |  2015  |  Journal of Leukocyte Biology

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Trying to cure HIV with immunotherapy: not so simple

Stephen J Kent

Journal article  |  2015  |  The Lancet HIV

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Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates

Jessica Li, Fatma Ahmet, Lucy C Sullivan, Andrew G Brooks, Stephen J Kent, Robert De Rose, Andres M Salazar, Caetano Reis e Sousa, Ken Shortman, Mireille H Lahoud, William R Heath, Irina Caminschi

Journal article  |  2015  |  European Journal of Immunology

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Antibody-Dependent Effector Functions Against HIV Decline in Subjects Receiving Antiretroviral Therapy

Vijaya Madhavi, Fernanda E Ana-Sosa-Batiz, Sinthujan Jegaskanda, Rob J Center, Wendy R Winnall, Matthew S Parsons, Jintanat Ananworanich, David A Cooper, Anthony D Kelleher, Denise Hsu, Sarah Pett, Ivan Stratov, Marit Kramski, Stephen J Kent

Journal article  |  2015  |  Journal of Infectious Diseases

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Antiretroviral therapy initiation in an Australian cohort: implications for increased use of antiretroviral therapy

I Stratov, SJ Kent

Journal article  |  2015  |  European Journal of Clinical Microbiology & Infectious Diseases

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Engineering Poly(ethylene glycol) Particles for Improved Biodistribution

Jiwei Cui, Robert De Rose, Karen Alt, Sheilajen Alcantara, Brett M Paterson, Kang Liang, Ming Hu, Joseph J Richardson, Yan Yan, Charmaine M Jeffery, Roger I Price, Karlheinz Peter, Christoph E Hagemeyer, Paul S Donnelly, Stephen J Kent, Frank Caruso

Journal article  |  2015  |  ACS Nano

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MAIT cells are depleted early but retain functional cytokine expression in HIV infection

Caroline S Fernandez, Thakshila Amarasena, Anthony D Kelleher, Jamie Rossjohn, James McCluskey, Dale I Godfrey, Stephen J Kent

Journal article  |  2015  |  Immunology and Cell Biology

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The role of HIV-specific antibody-dependent cellular cytotoxicity in HIV prevention and the influence of the HIV-1 Vpu protein

Marit Kramski, Ivan Stratov, Stephen J Kent

Journal article  |  2015  |  AIDS

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Prime-Boost Vaccination: Impact on the HIV-1 Vaccine Field

R De Rose, SJ Kent, C Ranasinghe

Book Chapter  |  2015

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Slaying the Trojan Horse: Natural Killer Cells Exhibit Robust Anti-HIV-1 Antibody-Dependent Activation and Cytolysis against Allogeneic T Cells

Shayarana L Gooneratne, Jonathan Richard, Wen Shi Lee, Andres Finzi, Stephen J Kent, Matthew S Parsons

Journal article  |  2015  |  Journal of Virology

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Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity in Intravenous Immunoglobulin as a Potential Therapeutic Against Emerging Influenza Viruses

Sinthujan Jegaskanda, Kirsten Vandenberg, Karen L Laurie, Liyen Loh, Marit Kramski, Wendy R Winnall, Katherine Kedzierska, Steven Rockman, Stephen J Kent

Journal article  |  2014  |  Journal of Infectious Diseases

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Linking Pig-Tailed Macaque Major Histocompatibility Complex Class I Haplotypes and Cytotoxic T Lymphocyte Escape Mutations in Simian Immunodeficiency Virus Infection

Shayarana L Gooneratne, Hamid Alinejad-Rokny, Diako Ebrahimi, Patrick S Bohn, Roger W Wiseman, David H O'Connor, Miles P Davenport, Stephen J Kent

Journal article  |  2014  |  Journal of Virology

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Modeling the Timing of Antilatency Drug Administration during HIV Treatment

Janka Petravic, Alexey Martyushev, Jeanette C Reece, Stephen J Kent, Miles P Davenport

Journal article  |  2014  |  Journal of Virology

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Role of education and differentiation in determining the potential of natural killer cells to respond to antibody-dependent stimulation

Matthew S Parsons, Liyen Loh, Shayarana Gooneratne, Rob J Center, Stephen J Kent

Journal article  |  2014  |  AIDS

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Modified Vaccinia Virus Ankara Encoding Influenza Virus Hemagglutinin Induces Heterosubtypic Immunity in Macaques

Nicholas W Florek, Jason T Weinfurter, Sinthujan Jegaskanda, Joseph N Brewoo, Tim D Powell, Ginger R Young, Subash C Das, Masato Hatta, Karl W Broman, Olav Hungnes, Susanne G Dudman, Yoshihiro Kawaoka, Stephen J Kent, Dan T Stinchcomb, Jorge E Osorio, Thomas C Friedrich

Journal article  |  2014  |  Journal of Virology

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Tentative first steps to eradicate latent HIV

Stephen J Kent, Miles P Davenport

Journal article  |  2014  |  The Lancet HIV

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Downregulation of Interleukin-18-Mediated Cell Signaling and Interferon Gamma Expression by the Hepatitis B Virus e Antigen

S Jegaskanda, SH Ahn, N Skinner, AJ Thompson, T Ngyuen, J Holmes, R De Rose, M Navis, WR Winnall, M Kramski, G Bernardi, J Bayliss, D Colledge, V Sozzi, K Visvanathan, SA Locarnini, SJ Kent, PA Revill

Journal article  |  2014  |  Journal of Virology

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HIV-specific antibody-dependent phagocytosis matures during HIV infection

Fernanda Ana-Sosa-Batiz, Angus PR Johnston, Haiyin Liu, Robert J Center, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Jaranit Kaewkungwal, Jerome H Kim, Nelson L Michael, Anthony D Kelleher, Ivan Stratov, Stephen J Kent, Marit Kramski

Journal article  |  2014  |  Immunology and Cell Biology

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Breadth of HIV-1 Env-specific antibody-dependent cellular cytotoxicity: relevance to global HIV vaccine design

Vijaya Madhavi, Leia H Wren, Rob J Center, Christopher Gonelli, Wendy R Winnall, Matthew S Parsons, Marit Kramski, Stephen J Kent, Ivan Stratov

Journal article  |  2014  |  AIDS

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The maturation of antibody technology for the HIV epidemic

Wendy R Winnall, Matthew D Beasley, Rob J Center, Matthew S Parsons, Ben R Kiefel, Stephen J Kent

Journal article  |  2014  |  Immunology and Cell Biology

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NKT cell depletion in humans during early HIV infection

Caroline S Fernandez, Anthony D Kelleher, Robert Finlayson, Dale I Godfrey, Stephen J Kent

Journal article  |  2014  |  Immunology and Cell Biology

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Influenza-Specific Antibody-Dependent Cellular Cytotoxicity: Toward a Universal Influenza Vaccine

Sinthujan Jegaskanda, Patrick C Reading, Stephen J Kent

Journal article  |  2014  |  Journal of Immunology

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Measuring Turnover of SIV DNA in Resting CD4 T Cells Using Pyrosequencing: Implications for the Timing of HIV Eradication Therapies

Jeanette C Reece, Alexey Martyushev, Janka Petravic, Andrew Grimm, Shayarana Gooneratne, Thakshila Amaresena, Robert De Rose, Liyen Loh, Miles P Davenport, Stephen J Kent

Journal article  |  2014  |  PLoS One

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Polymorphisms and Interspecies Differences of the Activating and Inhibitory Fc gamma RII of Macaca nemestrina Influence the Binding of Human IgG Subclasses

Halina M Trist, Peck Szee Tan, Bruce D Wines, Paul A Ramsland, Eva Orlowski, Janine Stubbs, Elizabeth E Gardiner, Geoffrey A Pietersz, Stephen J Kent, Ivan Stratov, Dennis R Burton, P Mark Hogarth

Journal article  |  2014  |  The Journal of Immunology

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Toward Improved Influenza Vaccines

Stephen J Kent

Journal article  |  2014  |  Journal of Infectious Diseases

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The High Cost of Fidelity

Sarah B Lloyd, Stephen J Kent, Wendy R Winnall

Journal article  |  2014  |  AIDS Research and Human Retroviruses

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Anti-HIV Antibody-Dependent Activation of NK Cells Impairs NKp46 Expression

Matthew S Parsons, Chi-Chang Tang, Sinthujan Jegaskanda, Robert J Center, Andrew G Brooks, Ivan Stratov, Stephen J Kent

Journal article  |  2014  |  Journal of Immunology

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Characterisation of macaque testicular leucocyte populations and T-lymphocyte immunity

Robert De Rose, Caroline S Fernandez, Mark P Hedger, Stephen J Kent, Wendy R Winnall

Journal article  |  2013  |  Journal of Reproductive Immunology

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Standard Trivalent Influenza Virus Protein Vaccination Does Not Prime Antibody-Dependent Cellular Cytotoxicity in Macaques

Sinthujan Jegaskanda, Thakshila H Amarasena, Karen L Laurie, Tan Hyon-Xhi, Jeff Butler, Matthew S Parsons, Sheilajen Alcantara, Janka Petravic, Miles P Davenport, Aeron C Hurt, Patrick C Reading, Stephen J Kent

Journal article  |  2013  |  Journal of Virology

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Obstacles to ideal anti-HIV antibody-dependent cellular cytotoxicity responses

Leia H Wren, Ivan Stratov, Stephen J Kent, Matthew S Parsons

Journal article  |  2013  |  Vaccine

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Decreased HIV-Specific Antibody-Dependent Cellular Cytotoxicity in HIV-Infected Subjects on cART: Implications for Therapeutic Vaccines

M Kramski, V Madhavi, S Jegaskanda, RJ Center, FE Ana Sosa Batiz, J Ananworanich, D Cooper, A Kelleher, D Hsu, SJ Kent

Conference Proceedings  |  2013  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

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Age-Associated Cross-reactive Antibody-Dependent Cellular Cytotoxicity Toward 2009 Pandemic Influenza A Virus Subtype H1N1

Sinthujan Jegaskanda, Karen L Laurie, Thakshila H Amarasena, Wendy R Winnall, Marit Kramski, Robert De Rose, Ian G Barr, Andrew G Brooks, Patrick C Reading, Stephen J Kent

Journal article  |  2013  |  Journal of Infectious Diseases

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In-vivo stimulation of macaque natural killer T cells with -galactosylceramide

CS Fernandez, S Jegaskanda, DI Godfrey, SJ Kent

Journal article  |  2013  |  Clinical and Experimental Immunology

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The role of T cell immunity in HIV-1 infection

C Mee Ling Munier, Anthony D Kelleher, Stephen J Kent, Robert De Rose

Journal article  |  2013  |  Current Opinion in Virology

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Serial study of lymph node cell subsets using fine needle aspiration in pigtail macaques

Yin Xu, Caroline Fernandez, Sheilajen Alcantara, Michelle Bailey, Robert De Rose, Anthony D Kelleher, John Zaunders, Stephen J Kent

Journal article  |  2013  |  Journal of Immunological Methods

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Mechanically Tunable, Self-Adjuvanting Nanoengineered Polypeptide Particles

Jiwei Cui, Robert De Rose, James P Best, Angus PR Johnston, Sheilajen Alcantara, Kang Liang, Georgina K Such, Stephen J Kent, Frank Caruso

Journal article  |  2013  |  Advanced Materials

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The search for an HIV cure: tackling latent infection

Stephen J Kent, Jeanette C Reece, Janka Petravic, Alexey Martyushev, Marit Kramski, Robert De Rose, David A Cooper, Anthony D Kelleher, Sean Emery, Paul U Cameron, Sharon R Lewin, Miles P Davenport

Journal article  |  2013  |  The Lancet Infectious Diseases

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HIV-Specific Antibody Immunity Mediated Through NK Cells and Monocytes

Marit Kramski, Matthew S Parsons, Ivan Stratov, Stephen J Kent

Journal article  |  2013  |  Current HIV Research

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Antibody Responses to Human Immunodeficiency Virus Envelope from Infections with Multiple Subtypes Utilize the 1F7-Idiotypic Repertoire

Matthew S Parsons, Robert J Center, Jean-Pierre Routy, Danielle Rouleau, Roger LeBlanc, Mark A Wainberg, Cecile L Tremblay, Marcel D Zannou, Stephen J Kent, Michael D Grant, Nicole F Bernard

Journal article  |  2013  |  AIDS Research and Human Retroviruses

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Antibody-Dependent Cellular Cytotoxicity Is Associated with Control of Pandemic H1N1 Influenza Virus Infection of Macaques

Sinthujan Jegaskanda, Jason T Weinfurter, Thomas C Friedrich, Stephen J Kent

Journal article  |  2013  |  Journal of Virology

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Activation of NK cells by HIV-specific ADCC antibodies Role for granulocytes in expressing HIV-1 peptide epitopes

Vijaya Madhavi, Marjon Navis, Amy W Chung, Gamze Isitman, Leia H Wren, Robert De Rose, Stephen J Kent, Ivan Stratov

Journal article  |  2013  |  Human Vaccines & Immunotherapeutics

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Simian Immunodeficiency Virus Infects Follicular Helper CD4 T Cells in Lymphoid Tissues during Pathogenic Infection of Pigtail Macaques

Yin Xu, Chris Weatherall, Michelle Bailey, Sheilajen Alcantara, Robert De Rose, Jerome Estaquier, Kim Wilson, Kazuo Suzuki, Jacques Corbeil, David A Cooper, Stephen J Kent, Anthony D Kelleher, John Zaunders

Journal article  |  2013  |  Journal of Virology

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Trivalent Live Attenuated Influenza-Simian Immunodeficiency Virus Vaccines: Efficacy and Evolution of Cytotoxic T Lymphocyte Escape in Macaques

Jeanette C Reece, Sheilajen Alcantara, Shayarana Gooneratne, Sinthujan Jegaskanda, Thakshila Amaresena, Caroline S Fernandez, Karen Laurie, Aeron Hurt, Shelby L O'Connor, Max Harris, Janka Petravic, Alexey Martyushev, Andrew Grimm, Miles P Davenport, John Stambas, Robert De Rose, Stephen J Kent

Journal article  |  2013  |  Journal of Virology

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Induction of SerpinB2 and Th1/Th2 Modulation by SerpinB2 during Lentiviral Infections In Vivo

Lee D Major, Thomas S Partridge, Joy Gardner, Stephen J Kent, Robert de Rose, Andreas Suhrbier, Wayne A Schroder

Journal article  |  2013  |  PLoS One

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Isotype-switched immunoglobulin G antibodies to HIV Gag proteins may provide alternative or additional immune responses to 'protective' human leukocyte antigen-B alleles in HIV controllers

Martyn A French, Rob J Center, Kim M Wilson, Ibrahim Fleyfel, Sonia Fernandez, Anna Schorcht, Ivan Stratov, Marit Kramski, Stephen J Kent, Anthony D Kelleher

Journal article  |  2013  |  AIDS

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Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity Antibodies in the Absence of Neutralizing Antibodies

Sinthujan Jegaskanda, Emma R Job, Marit Kramski, Karen Laurie, Gamze Isitman, Robert de Rose, Wendy R Winnall, Ivan Stratov, Andrew G Brooks, Patrick C Reading, Stephen J Kent

Journal article  |  2013  |  Journal of Immunology

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Specific antibody-dependent cellular cytotoxicity responses associated with slow progression of HIV infection

Leia H Wren, Amy W Chung, Gamze Isitman, Anthony D Kelleher, Matthew S Parsons, Janaki Amin, David A Cooper, Ivan Stratov, Marjon Navis, Stephen J Kent

Journal article  |  2013  |  Immunology

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Characterization of the kynurenine pathway and quinolinic Acid production in macaque macrophages.

Chai K Lim, Margaret MC Yap, Stephen J Kent, Gabriel Gras, Boubekeur Samah, Jane C Batten, Robert De Rose, Benjamin Heng, Bruce J Brew, Gilles J Guillemin

Journal article  |  2013  |  International Journal of Tryptophan Research

The kynurenine pathway (KP) and one of its end-products, the excitotoxin quinolinic acid (QUIN), are involved in the pathogenesis ..

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Azithromycin: more lethal than chloramphenicol?

Ivan Stratov, Justin Denholm, Stephen J Kent

Journal article  |  2013  |  Sexual Health

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HIV-specific antibody-dependent cellular cytotoxicity: a novel vaccine modality

Vijaya Madhavi, Stephen J Kent, Ivan Stratov

Journal article  |  2012  |  Expert Review of Clinical Immunology

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Role of monocytes in mediating HIV-specific antibody-dependent cellular cytotoxicity

M Kramski, A Schorcht, APR Johnston, GF Lichtfuss, S Jegaskanda, R De Rose, I Stratov, AD Kelleher, MA French, RJ Center, A Jaworowski, SJ Kent

Journal article  |  2012  |  Journal of Immunological Methods

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Anti-HIV-1 antibody-dependent cellular cytotoxicity mediated by hyperimmune bovine colostrum IgG

Marit Kramski, Gregor F Lichtfuss, Marjon Navis, Gamze Isitman, Leia Wren, Grant Rawlin, Rob J Center, Anthony Jaworowski, Stephen J Kent, Damian FJ Purcell

Journal article  |  2012  |  European Journal of Immunology

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Critical role for monocytes in mediating HIV-specific antibody-dependent cellular cytotoxicity

M Kramski, GF Lichtfuss, A Schorcht, AP Johnston, R De Rose, R Center, A Jawarowski, S Kent

Journal article  |  2012  |  RETROVIROLOGY

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Loss of Control of HIV Viremia Associated with the Fat Malabsorption Drug Orlistat

Stephen J Kent

Journal article  |  2012  |  AIDS Research and Human Retroviruses

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Loss of control of HIV viremia associated with the fat malabsorption drug orlistat.

Stephen J Kent

Journal article  |  2012  |  AIDS research and human retroviruses

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Ex-vivo alpha-Galactosylceramide activation of NKT cells in humans and macaques

Caroline S Fernandez, Garth Cameron, Dale I Godfrey, Stephen J Kent

Journal article  |  2012  |  Journal of Immunological Methods

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Characterisation of simian immunodeficiency virus-infected cells in pigtail macaques

Wendy R Winnall, Amy Sexton, Sheilajen Alcantara, Sarah Roath, Robert De Rose, Stephen J Kent

Journal article  |  2012  |  Virology

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Influence of Cytokines on HIV-Specific Antibody-Dependent Cellular Cytotoxicity Activation Profile of Natural Killer Cells

Leia Wren, Matthew S Parsons, Gamze Isitman, Robert J Center, Anthony D Kelleher, Ivan Stratov, Nicole F Bernard, Stephen J Kent

Journal article  |  2012  |  PLoS One

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Long-lived epithelial immunity by tissue-resident memory T (T-RM) cells in the absence of persisting local antigen presentation

Laura K Mackay, Angus T Stock, Joel Z Ma, Claerwen M Jones, Stephen J Kent, Scott N Mueller, William R Heath, Francis R Carbone, Thomas Gebhardt

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

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An "Escape Clock'' for Estimating the Turnover of SIV DNA in Resting CD4 T Cells

Jeanette Reece, Janka Petravic, Mehala Balamurali, Liyen Loh, Shayarana Gooneratne, Rob De Rose, Stephen J Kent, Miles P Davenport

Journal article  |  2012  |  PLoS Pathogens

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HIV Infection Abrogates the Functional Advantage of Natural Killer Cells Educated through KIR3DL1/HLA-Bw4 Interactions To Mediate Anti-HIV Antibody-Dependent Cellular Cytotoxicity

Matthew S Parsons, Leia Wren, Gamze Isitman, Marjon Navis, Ivan Stratov, Nicole F Bernard, Stephen J Kent

Journal article  |  2012  |  Journal of Virology

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Comparison of Influenza and SIV Specific CD8 T Cell Responses in Macaques

Sinthujan Jegaskanda, Jeanette C Reece, Robert De Rose, John Stambas, Lucy Sullivan, Andrew G Brooks, Stephen J Kent, Amy Sexton

Journal article  |  2012  |  PLoS One

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Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine Development.

Gamze Isitman, Ivan Stratov, Stephen J Kent

Journal article  |  2012  |  Advances in Virology

The HIV-1 genome is malleable and a difficult target tot vaccinate against. It has long been recognised that cytotoxic T lymphocyt..

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Evidence of HIV-Specific ADCC Immune Escape

AW Chung, G Isitman, M Navis, M Kramski, RJ Center, SJ Kent, I Stratov

Conference Proceedings  |  2011  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

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Live Attenuated Influenza-SIV Vaccines: Efficacy Against Mucosal Challenge in Macaques

SJ Kent, S Jegaskanda, J Reece, T Ameresena, A Sexton, C Fernandez, J Stambas, A Brooks, R De Rose

Conference Proceedings  |  2011  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

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Primary Immune Responses to Vaccinia Virus Vaccination: The Role of Cytotoxic Effector CD4 T Cells in the Generation of Human T Cell Memory

CM Munier, S Ip, M Bailey, Y Xu, S Liu, DA Cooper, SJ Kent, JJ Zaunders, AD Kelleher

Conference Proceedings  |  2011  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

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NK Cell Function and Antibodies Mediating ADCC in HIV-1-Infected Viremic and Controller Patients

Susanne E Johansson, Erik Rollman, Amy W Chung, Rob J Center, Bo Hejdeman, Ivan Stratov, Jorma Hinkula, Britta Wahren, Klas Kaerre, Stephen J Kent, Louise Berg

Journal article  |  2011  |  Viral Immunology

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HIV Infection Eliminates the Antibody-Dependent Cellular Cytotoxicity (ADCC) Functional Advantage of KIR3DL1-Expressing NK Cells from HLA-Bw4 Carriers

MS Parsons, L Wren, G Isitman, M Navis, I Stratov, NF Bernard, SJ Kent

Conference Proceedings  |  2011  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

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Broad ADCC Responses and ADCC Directed at VPU Epitopes in Humans Is Associated with Slow Progression of HIV

LH Wren, M Navis, A Chung, G Isitman, AD Kelleher, I Stratov, SJ Kent

Conference Proceedings  |  2011  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

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Activation of NK Cells by ADCC Antibodies and HIV Disease Progression

Amy W Chung, Marjon Navis, Gamze Isitman, Leia Wren, Julie Silvers, Janaki Amin, Stephen J Kent, Ivan Stratov

Journal article  |  2011  |  JAIDS Journal of Acquired Immune Deficiency Syndromes

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Replication-Competent Simian Immunodeficiency Virus (SIV) Gag Escape Mutations Archived in Latent Reservoirs during Antiretroviral Treatment of SIV-Infected Macaques

Suzanne E Queen, Brian M Mears, Kathleen M Kelly, Jamie L Dorsey, Zhaohao Liao, Jason B Dinoso, Lucio Gama, Robert J Adams, M Christine Zink, Janice E Clements, Stephen J Kent, Joseph L Mankowski

Journal article  |  2011  |  Journal of Virology

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ACCELERATING THE DEVELOPMENT OF AN AIDS VACCINE: THE AIDS VACCINE FOR ASIA NETWORK (AVAN)

Punnee Pitisuttithum, Supachai Rerks-Ngarm, Joseph Chiu, Jerome Kim, Michael Benenson, Stephen J Kent, Hiko Tamashiro, Amapola Manrique, Alan Bernstein, Rajat Goyal, Rossana A Ditangco, David A Cooper, Saladin Osmanov, Bonnie Mathieson, Eric Sandstrom, Jose Esparza, Rodney Hoff, Yiming Shao

Journal article  |  2011  |  Southeast Asian Journal of Tropical Medicine and Public Health

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Screening and confirmatory testing of MHC class I alleles in pig-tailed macaques

Caroline S Fernandez, Jeanette C Reece, Uus Saepuloh, Robert De Rose, Diah Ishkandriati, David H O'Connor, Roger W Wiseman, Stephen J Kent

Journal article  |  2011  |  Immunogenetics

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Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressure

Amy W Chung, Gamze Isitman, Marjon Navis, Marit Kramski, Rob J Center, Stephen J Kent, Ivan Stratov

Journal article  |  2011  |  Proceedings of the National Academy of Sciences of the United States of America

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HIV vaccine efficacy trial: Glimmers of hope and the potential role of antibody-dependent cellular cytotoxicity

Leia Wren, Stephen J Kent

Journal article  |  2011  |  Human Vaccines

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Activation of NK Cells by ADCC Responses During Early HIV Infection

Amy W Chung, Marjon Navis, Gamze Isitman, Rob Centre, Robert Finlayson, Mark Bloch, Linda Gelgor, Antony Kelleher, Stephen J Kent, Ivan Stratov

Journal article  |  2011  |  Viral Immunology

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Pol as a target for antibody dependent cellular cytotoxicity responses in HIV-1 infection

Gamze Isitman, Amy W Chung, Marjon Navis, Stephen J Kent, Ivan Stratov

Journal article  |  2011  |  Virology

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Does Cytolysis by CD8( ) T Cells Drive Immune Escape in HIV Infection?

Mehala Balamurali, Janka Petravic, Liyen Loh, Sheilajen Alcantara, Stephen J Kent, Miles P Davenport

Journal article  |  2010  |  Journal of Immunology

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SIV Gag Escape from CD8 T Cell Control in the CNS During Anti-retroviral Treatment

Joseph L Mankowski, Suzanne E Queen, Jason B Dinoso, Christine Zink, Janice E Clements, Stephen J Kent

Conference Proceedings  |  2010  |  JOURNAL OF NEUROVIROLOGY

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Timing of Immune Escape Linked to Success or Failure of Vaccination

Jeanette C Reece, Liyen Loh, Sheilajen Alcantara, Caroline S Fernandez, John Stambas, Amy Sexton, Robert De Rose, Janka Petravic, Miles P Davenport, Stephen J Kent

Journal article  |  2010  |  PLoS One

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Defining the objectives of the AIDS vaccine for Asia network: report of the WHO-UNAIDS/Global HIV vaccine enterprise regional consultation on expanding AIDS vaccine research and development capacity in Asia

Supachai Rerks-Ngarm, Punnee Pitisuttithum, Nirmal Ganguly, Linqi Zhang, Hiko Tamashiro, David A Cooper, Chhi Vun Mean, Budiman Bela, Rossana Ditangco, Van Kinh Nguyen, Alan Bernstein, Saladin Osmanov, Bonnie Mathieson, Stephen J Kent, Yiming Shao

Journal article  |  2010  |  Current Opinion in HIV and AIDS

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AIDS Vaccine for Asia Network (AVAN): Expanding the Regional Role in Developing HIV Vaccines

Stephen J Kent, David A Cooper, Mean Chhi Vun, Yiming Shao, Linqi Zhang, Nirmal Ganguly, Budiman Bela, Hiko Tamashiro, Rossana Ditangco, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Van Kinh Nguyen, Alan Bernstein, Saladin Osmanov

Journal article  |  2010  |  PLoS Medicine

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HOST GENETIC RESISTANCE TO SIV-INDUCED CNS DISEASE: A NEUROPROTECTIVE MHC CLASS I ALLELE IN PIGTAILED MACAQUES

Joseph L Mankowski, Suzanne E Queen, Caroline S Fernandez, Patrick M Tarwater, Jami M Karper, Robert J Adams, Stephen J Kent

Journal article  |  2010  |  JOURNAL OF MEDICAL PRIMATOLOGY

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Designing immunity to HIV: Manipulating antibody-dependent cellular cytotoxicity antibodies

G Isitman, M Navis, SJ Kent, I Stratov

Journal article  |  2009  |  HIV Therapy

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Induction of HIV-1 subtype B and AE-specific neutralizing antibodies in mice and macaques with DNA prime and recombinant gp140 protein boost regimens

Rob J Center, Adam K Wheatley, Shahan M Campbell, Adriana J Gaeguta, Viv Peut, Sheilajen Alcantara, Carly Siebentritt, Stephen J Kent, Damian FJ Purcell

Journal article  |  2009  |  Vaccine

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A Protective Vaccine Delivery System for In Vivo T Cell Stimulation Using Nanoengineered Polymer Hydrogel Capsules

Amy Sexton, Paul G Whitney, Siow-Feng Chong, Alexander N Zelikin, Angus PR Johnston, Robert De Rose, Andrew G Brooks, Frank Caruso, Stephen J Kent

Journal article  |  2009  |  ACS Nano

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P10-07. Extremely rapid degranulation of NK cells activated by HIV-specific antibody dependent cellular cytotoxicity

A Chung, S Kent, I Stratov

Journal article  |  2009  |  Retrovirology

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P19-24. Evaluation of recombinant influenza-SIV vaccines in macaques

J Stambas, A Sexton, R De Rose, JC Reece, S Alcantara, L Loh, JM Moffat, K Laurie, A Hurt, PC Doherty, SJ Turner, SJ Kent

Journal article  |  2009  |  Retrovirology

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P17-03. Nanoengineered layer-by-layer capsules as a novel delivery system for HIV vaccines

A Sexton, PG Whitney, R De Rose, AN Zelikin, S Chong, AP Johnston, F Caruso, SJ Kent

Journal article  |  2009  |  Retrovirology

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P09-08. The complexity of the infecting inoculum determines the outcome of infection

L Loh, J Reece, J Petravic, R Center, M Davenport, SJ Kent

Journal article  |  2009  |  Retrovirology

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P09-07. Balancing reversion of CTL and neutralizing antibody escape mutations within HIV-1 Env upon transmission

V Peut, S Campbell, A Gaeguta, RJ Center, S Alcantara, C Fernandez, DF Purcell, SJ Kent

Journal article  |  2009  |  Retrovirology

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A paradigm for peptide vaccine delivery using viral epitopes encapsulated in degradable polymer hydrogel capsules

Siow-Feng Chong, Amy Sexton, Robert De Rose, Stephen J Kent, Alexander N Zelikin, Frank Caruso

Journal article  |  2009  |  Biomaterials

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Balancing Reversion of Cytotoxic T-Lymphocyte and Neutralizing Antibody Escape Mutations within Human Immunodeficiency Virus Type 1 Env upon Transmission

Viv Peut, Shahan Campbell, Adriana Gaeguta, Rob J Center, Kim Wilson, Sheilajen Alcantara, Caroline S Fernandez, Damian FJ Purcell, Stephen J Kent

Journal article  |  2009  |  Journal of Virology

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High Levels of Human Antigen-Specific CD4( ) T Cells in Peripheral Blood Revealed by Stimulated Coexpression of CD25 and CD134 (OX40)

John J Zaunders, Mee Ling Munier, Nabila Seddiki, Sarah Pett, Susanna Ip, Michelle Bailey, Yin Xu, Kai Brown, Wayne B Dyer, Min Kim, Robert de Rose, Stephen J Kent, Lele Jiang, Samuel N Breit, Sean Emery, Anthony L Cunningham, David A Cooper, Anthony D Kelleher

Journal article  |  2009  |  Journal of Immunology

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Impaired Quality of the Hepatitis B Virus (HBV)-Specific T-Cell Response in Human Immunodeficiency Virus Type 1-HBV Coinfection

J Judy Chang, Sunee Sirivichayakul, Anchalee Avihingsanon, Alex JV Thompson, Peter Revill, David Iser, John Slavin, Supranee Buranapraditkun, Pip Marks, Gail Matthews, David A Cooper, Stephen J Kent, Paul U Cameron, Joe Sasadeusz, Paul Desmond, Stephen Locarnini, Gregory J Dore, Kiat Ruxrungtham, Sharon R Lewin

Journal article  |  2009  |  Journal of Virology

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Thrombocytopenia Is Strongly Associated With Simian AIDS in Pigtail Macaques

Sheilajen Alcantara, Jeanette Reece, Thakshila Amarasena, Robert De Rose, Joe Manitta, Janiki Amin, Stephen J Kent

Journal article  |  2009  |  Journal of Acquired Immune Deficiency Syndromes (JAIDS)

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Evaluation of Recombinant Influenza Virus-Simian Immunodeficiency Virus Vaccines in Macaques

Amy Sexton, Robert De Rose, Jeanette C Reece, Sheilajen Alcantara, Liyen Loh, Jessica M Moffat, Karen Laurie, Aeron Hurt, Peter C Doherty, Stephen J Turner, Stephen J Kent, John Stambas

Journal article  |  2009  |  Journal of Virology

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Differential patterns of immune escape at Tat-specific cytotoxic T cell epitopes in pigtail macaques

Rosemarie D Mason, Robert De Rose, Stephen J Kent

Journal article  |  2009  |  Virology

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Complexity of the Inoculum Determines the Rate of Reversion of SIV Gag CD8 T Cell Mutant Virus and Outcome of Infection

Liyen Loh, Jeanette C Reece, Caroline S Fernandez, Sheilajen Alcantara, Robert Center, Jane Howard, Damian FJ Purcell, Mehala Balamurali, Janka Petravic, Miles P Davenport, Stephen J Kent

Journal article  |  2009  |  PLoS Pathogens

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Peripheral NKT Cells in Simian Immunodeficiency Virus-Infected Macaques

Caroline S Fernandez, Angela C Chan, Konstantinos Kyparissoudis, Robert De Rose, Dale I Godfrey, Stephen J Kent

Journal article  |  2009  |  Journal of Virology

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Substantial envelope-specific CD8 T-cell immunity fails to control siv disease

Viv Peut, Stephen J Kent

Journal article  |  2009  |  Virology

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Inactivated Simian Immunodeficiency Virus-Pulsed Autologous Fresh Blood Cells as an Immunotherapy Strategy

Rosemarie D Mason, Sheilajen Alcantara, Viv Peut, Liyen Loh, Jeffrey D Lifson, Robert De Rose, Stephen J Kent

Journal article  |  2009  |  Journal of Virology

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Rapid Degranulation of NK Cells following Activation by HIV-Specific Antibodies

Amy W Chung, Erik Rollman, Rob J Center, Stephen J Kent, Ivan Stratov

Journal article  |  2009  |  Journal of Immunology

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The complexity of the infecting inoculum determines the outcome of infection

L Loh, J Reece, J Petravic, R Center, M Davenport, SJ Kent

Journal article  |  2009  |  Retrovirology

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Balancing reversion of CTL and neutralizing antibody mutations within HIV-1 Env upon transmission

V Peut, S Campbell, A Gaeguta, RJ Center, S Alcantara, C Fernandez, DF Purcell, SJ Kent

Journal article  |  2009  |  Retrovirology

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Natural Host Genetic Resistance to SIV CNS Disease: A Neuroprotective MHC Class I Allele in Pigtailed Macaques

Joseph L Mankowski, Suzanne E Queen, Caroline S Fernandez, Patrick M Tarwater, Jami M Karper, Robert J Adams, Stephen J Kent

Conference Proceedings  |  2009  |  JOURNAL OF NEUROVIROLOGY

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Binding, Internalization, and Antigen Presentation of Vaccine-Loaded Nanoengineered Capsules in Blood

Robert De Rose, Alexander N Zelikin, Angus PR Johnston, Amy Sexton, Siow-Feng Chong, Christina Cortez, William Mulholland, Frank Caruso, Stephen J Kent

Journal article  |  2008  |  Advanced Materials

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Rates of HIV immune escape and reversion: implications for vaccination

Miles P Davenport, Liyen Loh, Janka Petravic, Stephen J Kent

Journal article  |  2008  |  Trends in Immunology (formerly Immunology Today)

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Protection afforded by live attenuated SIV is associated with rapid killing kinetics of CTLs

Erik Rollman, Rosemarie D Mason, Jie Lin, Andrew G Brooks, Stephen J Kent

Journal article  |  2008  |  Journal of Medical Primatology

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Safety, immunogenicity and efficacy of peptide-pulsed cellular immunotherapy in macaques

Robert De Rose, Rosemarie D Mason, Liyen Loh, Viv Peut, Miranda Z Smith, Caroline S Fernandez, Sheilajen Alcantara, Thakshila Amarasena, Jeanette Reece, Nabila Seddiki, Anthony D Kelleher, John Zaunders, Stephen J Kent

Journal article  |  2008  |  Journal of Medical Primatology

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Low pre-infection levels and loss of central memory CD4 T cells may predict rapid progression in SIV-infected pigtail macaques

Rosemarie D Mason, Robert De Rose, Nabila Seddiki, Anthony D Kelleher, Stephen J Kent

Journal article  |  2008  |  Virology

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Natural Host Genetic Resistance to Lentiviral CNS Disease: A Neuroprotective MHC Class I Allele in SIV-Infected Macaques

Joseph L Mankowski, Suzanne E Queen, Caroline S Fernandez, Patrick M Tarwater, Jami M Karper, Robert J Adams, Stephen J Kent

Journal article  |  2008  |  PLoS One

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The Utility of ADCC Responses in HIV Infection

Amy Chung, Erik Rollman, Susanne Johansson, Stephen J Kent, Ivan Stratov

Journal article  |  2008  |  Current HIV Research

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Natural Killer Cell Mediated Antibody Dependent Cellular Cytotoxicity

A Chung, E Rollman, SJ Kent, I Stratov

Conference Proceedings  |  2008  |  AIDS RESEARCH AND HUMAN RETROVIRUSES

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Delivery of immunotherapy with peptide-pulsed blood in macaques

Robert De Rose, Caroline S Fernandez, Liyen Loh, Viv Peut, Rosemarie D Mason, Sheilajen Alcantara, Jeanette Reece, Stephen J Kent

Journal article  |  2008  |  Virology

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Anti-SIV Cytolytic Molecules in Pigtail Macaques

Erik Rollman, Stephen J Turner, Katherine Kedzierska, Stephen J Kent

Journal article  |  2008  |  AIDS Research and Human Retroviruses

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Limited maintenance of vaccine-induced simian immunodeficiency virus-specific CD8 T-cell receptor clonotypes after virus challenge

Miranda Z Smith, Tedi E Asher, Vanessa Venturi, Miles P Davenport, Daniel C Douek, David A Price, Stephen J Kent

Journal article  |  2008  |  Journal of Virology

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Quantification of Simian Immunodeficiency Virus Cytotoxic T Lymphocyte Escape Mutant Viruses

Liyen Loh, Stephen J Kent

Journal article  |  2008  |  AIDS Research and Human Retroviruses

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Robust NK cell-mediated human immunodeficiency virus (HIV)-specific antibody-dependent responses in HIV-infected subjects

Ivan Stratov, Amy Chung, Stephen J Kent

Journal article  |  2008  |  Journal of Virology

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Evaluation of recombinant Kunjin replicon SIV vaccines for protective efficacy in macaques

Stephen J Kent, Robert De Rose, Vlad V Mokhonov, Ekaterina I Mokhonova, Caroline S Fernandez, Sheilajen Alcantara, Erik Rollman, Rosemarie D Mason, Liyen Loh, Viv Peut, Jeanette C Reece, Xiang Ju Wang, Kim M Wilson, Andreas Suhrbier, Alexander Khromykh

Journal article  |  2008  |  Virology

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Control of viremia and prevention of AIDS following immunotherapy of SIV-infected macaques with peptide-pulsed blood

Robert De Rose, Caroline S Fernandez, Miranda Z Smith, C Jane Batten, Sheilajen Alcantara, Vivienne Peut, Erik Rollman, Liyen Loh, Rosemarie D Mason, Kim Wilson, Matthew G Law, Amanda J Handley, Stephen J Kent

Journal article  |  2008  |  PLoS Pathogens

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CD4( ) target cell availability determines the dynamics of immune escape and reversion in vivo

Janka Petravic, Liyen Loh, Stephen J Kent, Miles P Davenport

Journal article  |  2008  |  Journal of Virology

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CD4( ) T-cell subsets: what really counts in preventing HIV disease?

Rosemarie D Mason, Robert De Rose, Stephen J Kent

Journal article  |  2008  |  Expert Review of Vaccines

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Virus-specific T-cell immunity correlates with control of GB virus B infection in marmosets

David J Woollard, Gholarnreza Haqshenas, Xuebin Dong, Bridget F Pratt, Stephen J Kent, Eric J Gowans

Journal article  |  2008  |  Journal of Virology

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Vaccination and timing influence SIV immune escape viral dynamics in vivo

L Loh, J Petravic, CJ Batten, MP Davenport, SJ Kent

Journal article  |  2008  |  PLoS Pathogens

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Vaccination and timing influence SIV immune escape viral dynamics in vivo

Liyen Loh, Janka Petravic, C Jane Batten, Miles P Davenport, Stephen J Kent

Journal article  |  2008  |  PLoS Pathogens

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Utility of human immunodeficiency virus type 1 envelope as a T-cell immunogen

Viv Peut, Stephen J Kent

Journal article  |  2007  |  Journal of Virology

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The phenotype of hepatitis B virus-specific T cells differ in the liver and blood in chronic hepatitis B virus infection

J Judy Chang, Alexander JV Thompson, Kumar Visvanathan, Stephen J Kent, Paul U Cameron, Fiona Wightman, Paul Desmond, Stephen A Locarnini, Sharon R Lewin

Journal article  |  2007  |  Hepatology

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Killing kinetics of simian immunodeficiency virus-specific CD8( ) T cells: implications for HIV vaccine strategies

Erik Rollman, Miranda Z Smith, Andrew G Brooks, Damian FJ Purcell, Bartek Zuber, Ian A Ramshaw, Stephen J Kent

Journal article  |  2007  |  Journal of Immunology

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In vivo fitness costs of different gag CD8 T-cell escape mutant simian-human immunodeficiency viruses for macaques

Liyen Loh, C Jane Batten, Janka Petravic, Miles P Davenport, Stephen J Kent

Journal article  |  2007  |  Journal of Virology

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Vaccine-induced T cells control reversion of AIDS virus immune escape mutants

Caroline S Fernandez, Miranda Z Smith, C Jane Batten, Robert De Rose, Jeanette C Reece, Erik Rollman, Vanessa Venturi, Miles P Davenport, Stephen J Kent

Journal article  |  2007  |  Journal of Virology

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DNA/MVA prime-boost HIV vaccine

S Kent, R De Rose, E Rollman

Journal article  |  2007  |  Current Opinion in Investigational Drugs

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Drug evaluation: DNA/MVA prime-boost HIV vaccine

Stephen Kent, Robert De Rose, Erik Rollman

Journal article  |  2007  |  Current Opinion in Investigational Drugs

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The testis and epididymis are productively infected by SIV and SHIV in juvenile macaques during the post-acute stage of infection

Miranda Shehu-Xhilaga, Stephen Kent, Jane Batten, Sarah Ellis, Joel Van der Meulen, Moira O'Bryan, Paul U Cameron, Sharon R Lewin, Mark P Hedger

Journal article  |  2007  |  Retrovirology

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Comparative efficacy of subtype AE simian-human immunodeficiency virus priming and boosting vaccines in pigtail macaques

Robert De Rose, C Jane Batten, Miranda Z Smith, Caroline S Fernandez, Viv Peut, Scott Thomson, Ian A Ramshaw, Barbara EH Coupar, David B Boyle, Vanessa Venturi, Miles P Davenport, Stephen J Kent

Journal article  |  2007  |  Journal of Virology

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MHC class I allele frequencies in pigtail macaques of diverse origin

Bridget F Pratt, David H O'Connor, Bernard AP Lafont, Joseph L Mankowski, Caroline S Fernandez, Retno Triastuti, Andrew G Brooks, Stephen J Kent, Miranda Z Smith

Journal article  |  2006  |  Immunogenetics

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CD127( )CCR5( )CD38( ) CD4( ) Th1 effector cells are an early component of the primary immune response to vaccinia virus and precede development of interleukin-2( ) memory CD4( ) T cells

John J Zaunders, Wayne B Dyer, Mee Ling Munier, Susanna Ip, Jie Liu, Elisabeth Amyes, William Rawlinson, Robert De Rose, Stephen J Kent, John S Sullivan, David A Cooper, Anthony D Kelleher

Journal article  |  2006  |  Journal of Virology

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Comparative evaluation of simian, simian-human, and human immunodeficiency virus infections in the pigtail macaque (Macaca nemestrina) model

CJ Batten, R De Rose, KM Wilson, MB Agy, S Chea, I Stratov, DC Montefiori, SJ Kent

Journal article  |  2006  |  AIDS Research and Human Retroviruses

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Dose-response relationship of DNA and recombinant Fowlpox virus prime-boost HIV vaccines - Implications for future trials

Robert De Rose, Mark T Sullivan, C Jane Dale, Anthony D Kelleher, Sean Emery, David A Cooper, Ian A Ramshaw, David B Boyle, Stephen J Kent

Journal article  |  2006  |  Human Vaccines

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Fitness constraints on immune escape from HIV: Implications of envelope as a target for both HIV-specific T cells and antibody

V Peut, SJ Kent

Journal article  |  2006  |  Current HIV Research

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Fowlpox virus vaccines for HIV and SHIV clinical and pre-clinical trials

BEH Coupar, DFJ Purcell, SA Thomson, IA Ramshaw, SJ Kent, DB Boyle

Journal article  |  2006  |  Vaccine

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A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1

AD Kelleher, RL Puls, M Bebbington, D Boyle, R Ffrench, SJ Kent, S Kippax, DFJ Purcell, S Thomson, H Wand, DA Cooper, S Emery

Journal article  |  2006  |  AIDS

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Prime-boost strategies in DNA vaccines

C BATTEN, undefined Thomson, R DE ROSE, undefined Ranasinghe, undefined Medveczky, undefined Pumungkas, undefined Boyle, undefined Ramshaw, S KENT

Book Chapter  |  2006

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Characteristics of effective immune control of simian/human immunodeficiency virus in pigtail macaques

I Stratov, CJ Dale, S Chea, DC Montefiori, R De Rose, JC Reece, SJ Kent

Journal article  |  2006  |  AIDS Research and Human Retroviruses

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Short communication: characteristics of effective immune control of simian/human immunodeficiency virus in pigtail macaques.

Ivan Stratov, C Jane Dale, Socheata Chea, David C Montefiori, Robert De Rose, Jeanette C Reece, Stephen J Kent

Journal article  |  2006  |  AIDS Research and Human Retroviruses

Considerable evidence suggests both HIV-specific T cells and neutralizing antibodies (nAb) can, separately, assist control of vire..

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Prime-boost strategies in DNA vaccines.

C Jane Dale, Scott Thomson, Robert De Rose, Charani Ranasinghe, C Jill Medveczky, Joko Pamungkas, David B Boyle, Ian A Ramshaw, Stephen J Kent

Journal article  |  2006  |  Methods in molecular medicine

Induction of HIV-specific T-cell responses by vaccines may facilitate efficient control of HIV replication. Plasmid DNA vaccines a..

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The specificity and phenotype of intrahepatic and circulating HBV-specific T-cells differ in chronic HBV infection

JJ Chang, A Thompson, K Visvanathan, SJ Kent, PU Cameron, SA Locarnini, SR Lewin

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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Insights into effective SIV gag-specific CD8 T cell responses and fitness costs of viral escape

MZ Smith, CJ Batten, CS Fernandez, R De Rose, I Stratov, DH O'Connor, D Watkins, J Lin, AG Brooks, MP Davenport, SJ Kent

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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Control of T cell escape mutant viruses by effector T cells at transmission: Implications for the requirements of vaccine induced immunity to HIV

CS Fernandez, I Stratov, R De Rose, J Batten, MZ Smith, MB Agy, S Hu, K Krebs, DI Watkins, DH O'Connor, MP Davenport, SJ Kent

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

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Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3

SJ Kent, CJ Dale, C Ranasinghe, I Stratov, R De Rose, S Chea, DC Montefiori, S Thomson, IA Ramshaw, BEH Coupar, DB Boyle, M Law, KM Wilson, AJ Ramsay

Journal article  |  2005  |  Vaccine

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The pigtail macaque MHC class I allele Mane-A*10 presents an immundominant SIV Gag epitope: identification, tetramer development and implications of immune escape and reversion

MZ Smith, CS Fernandez, A Chung, CJ Dale, R De Rose, J Lin, AG Brooks, KC Krebs, DI Watkins, DH O'Connor, MP Davenport, SJ Kent

Journal article  |  2005  |  Journal of Medical Primatology

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Development of a synthetic consensus sequence scrambled antigen HIV-1 vaccine designed for global use

SA Thomson, AB Jaramillo, M Shoobridge, KJ Dunstan, B Everett, C Ranasinghe, SJ Kent, K Gao, J Medveckzy, RA Ffrench, IA Ramshaw

Journal article  |  2005  |  Vaccine

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Phenotypic and kinetic analysis of effective simian-human immunodeficiency virus-specific T cell responses in DNA- and fowlpox virus-vaccinated macaques

I Stratov, CJ Dale, SJ Kent

Journal article  |  2005  |  Virology

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Induction of T-cell immunity to antiretroviral drug-resistant human immunodeficiency virus type 1

I Stratov, CJ Dale, S Chea, J McCluskey, SJ Kent

Journal article  |  2005  |  Journal of Virology

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Reversion of immune escape HIV variants upon transmission: insights into effective viral immunity

SJ Kent, CS Fernandez, CJ Dale, MP Davenport

Journal article  |  2005  |  Trends in Microbiology

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Rapid viral escape at an immunodominant simian-human immunodeficiency virus cytotoxic T-lymphocyte epitope exacts a dramatic fitness cost

CS Fernandez, I Stratov, R De Rose, K Walsh, CJ Dale, MZ Smith, MB Agy, SL Hu, K Krebs, DI Watkins, DH O'Connor, MP Davenport, SJ Kent

Journal article  |  2005  |  Journal of Virology

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Comparison of whole gene and whole virus scrambled antigen approaches for DNA prime and fowlpox virus boost HIV type 1 vaccine regimens in macaques

J Pamungkas, R De Rose, D Iskandriati, R Noviana, Y Paramastri, CJ Dale, M Shoobridge, CJ Medveczky, IA Ramshaw, S Thomson, SJ Kent

Journal article  |  2005  |  AIDS Research and Human Retroviruses

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Subtype AE HIV-1 DNA and recombinant Fowlpoxvirus vaccines encoding five shared HIV-1 genes: safety and T cell immunogenicity in macaques

R De Rose, S Chea, CJ Dale, J Reece, CS Fernandez, KM Wilson, S Thomson, IA Ramshaw, BEH Coupar, DB Boyle, MT Sullivan, SJ Kent

Journal article  |  2005  |  Vaccine

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Reduced hepatitis B virus (HBV)-specific CD4( ) T-Cell responses in human immunodeficiency virus type 1-HBV-Coinfected individuals receiving HBV-active antiretroviral therapy

JJ Chang, F Wightman, A Bartholorneusz, A Ayres, SJ Kent, J Sasadeusz, SR Lewin

Journal article  |  2005  |  Journal of Virology

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Enhanced cellular immunity in macaques following a novel peptide immunotherapy

S Chea, CJ Dale, R De Rose, IA Rantshaw, SJ Kent

Journal article  |  2005  |  Journal of Virology

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Granulocyte contamination dramatically inhibits spot formation in AIDS virus-specific ELISpot assays: Analysis and strategies to ameliorate

R De Rose, EL Taylor, MG Law, PH van der Meide, SJ Kent

Journal article  |  2005  |  Journal of Immunological Methods

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Genetic influences on HIV infection: implications for vaccine development.

Miranda Z Smith, Stephen J Kent

Journal article  |  2005  |  Sexual Health

Human HIV infection is characterised by great variability in outcome. Much of this variability is due either to viral variation or..

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Analysis of pigtail macaque major histocompatibility complex class I molecules presenting immunodominant simian immunodeficiency virus epitopes

MZ Smith, CJ Dale, R De Rose, I Stratov, CS Fernandez, AG Brooks, J Weinfurter, K Krebs, C Riek, DI Watkins, DH O'Connor, SJ Kent

Journal article  |  2005  |  Journal of Virology

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Characterization of SIV infection in the male genital tract of juvenile macaques.

M Xhilaga, J Dale, M O'Bryan, M Hedger, S Kent, D de kretser

Conference Proceedings  |  2005  |  BIOLOGY OF REPRODUCTION

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Efficacy of DNA and fowlpox virus priming/boosting vaccines for simian/human immunodeficiency virus

CJ Dale, R De Rose, I Stratov, S Chea, DC Montefiori, S Thomson, IA Ramshaw, BEH Coupar, DB Boyle, M Law, SJ Kent

Journal article  |  2004  |  Journal of Virology

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Evaluation in macaques of HIV-1 DNA vaccines containing primate CpG motifs and fowlpoxvirus vaccines co-expressing IFN gamma or IL-12

CJ Dale, R De Rose, KM Wilson, HA Croom, S Thomson, BEH Coupar, A Ramsay, DFJ Purcell, R Ffrench, M Law, S Emery, DA Cooper, IA Ramshaw, DB Boyle, SJ Kent

Journal article  |  2004  |  Vaccine

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Evaluation in macaques of HIV-1 DNA vaccines containing primate CpG motifs and fowlpoxvirus vaccines co-expressing IFN? or IL-12

C DALE, R DEROSE, K WILSON, H CROOM, S THOMSON, B COUPAR, A RAMSAY, D PURCELL, R FFRENCH, M LAW

Journal article  |  2004  |  Vaccine

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Vaccines and vaccine strategies against HIV

I Stratov, R DeRose, DFJ Purcell, SJ Kent

Journal article  |  2004  |  Current Drug Targets

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Decreased neurotropism of nef long terminal repeat (nef/LTR)-deleted simian immunodeficiency virus

KA Thompson, SJ Kent, ME Gahan, DFJ Purcell, CA McLean, S Preiss, CJ Dale, SL Wesselingh

Journal article  |  2003  |  Journal of NeuroVirology

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Knowledge and commitment for action: the 14th International AIDS Conference, Barcelona, July 2002.

Stephen J Kent, C Jane Dale, Anne M Mijch

Journal article  |  2002  |  Medical Journal of Australia

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Chimeric human papilloma virus-simian/human immunodeficiency virus virus-like-particle vaccines: Immunogenicity and protective efficacy in macaques

CJ Dale, XSS Liu, R De Rose, DFJ Purcell, J Anderson, Y Xu, GR Leggatt, IH Frazer, SJ Kent

Journal article  |  2002  |  Virology

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Vaccines for HIV in the developing world - Commentary

SJ Kent

Journal article  |  2002  |  Internal Medicine Journal

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Evidence of recombination between 3 ' and 5 ' LTRs in macaques inoculated with SIV DNA

SJ Kent, CJ Dale, S Preiss, DFJ Purcell

Journal article  |  2002  |  AIDS Research and Human Retroviruses

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Vaccination with attenuated simian immunodeficiency virus by DNA inoculation

SJ Kent, CJ Dale, S Preiss, J Mills, D Campagna, DFJ Purcell

Journal article  |  2001  |  Journal of Virology

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Determining the immune mechanisms of protection from AIDS: correlates of immunity and the development of syngeneic macaques

SJ Kent, GL Ada, E Hayes, IM Lewis

Journal article  |  2001  |  Immunological Reviews

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Attenuated and wild-type HIV-1 infections and long terminal repeat-mediated gene expression from plasmids delivered by gene gun to human skin ex vivo and macaques in vivo

SJ Kent, PU Cameron, JC Reece, PR Thompson, DFJ Purcell

Journal article  |  2001  |  Virology

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Simian immunodeficiency virus infections in vervet monkeys (Clorocebus aethiops) at an Australian zoo

AK Joy, L Vogelnest, DJ Middleton, CJ Dale, D Campagna, DFJ Purcell, SJ Kent

Journal article  |  2001  |  Australian Veterinary Journal

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Infectivity of wild-type and deleted proviral SIV DNA.

DF Purcell, PU Cameron, J Mills, S Kent

Journal article  |  2001  |  Developments in biologicals

Live attenuated lentiviruses are potentially effective candidate HIV vaccines; however, delivery of these viruses in the field wou..

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Vaccines to prevent HIV and AIDS

SJ KENT

Journal article  |  2001  |  Microbiology Australia

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Nucleic acid vaccines - Tasks and tactics

BS McKenzie, AJ Corbett, JL Brady, CM Dyer, RA Strugnell, SJ Kent, DR Kramer, JS Boyle, AM Lew

Journal article  |  2001  |  Immunologic Research

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Induction of HIV-1-specific T-helper responses and type 1 cytokine secretion following therapeutic vaccination of macaques with a recombinant fowlpoxvirus co-expressing interferon-gamma

CJ Dale, A Zhao, SL Jones, DB Boyle, IA Ramshaw, SJ Kent

Journal article  |  2000  |  Journal of Medical Primatology

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Vaccines for HIV

CJ Dale, SJ Kent

Journal article  |  2000  |  Expert Opinion on Therapeutic Patents

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A recombinant avipoxvirus HIV-1 vaccine expressing interferon-gamma is safe and immunogenic in macaques

SJ Kent, A Zhao, CJ Dale, S Land, DB Boyle, IA Ramshaw

Journal article  |  2000  |  Vaccine

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Genetic vaccination strategies for enhanced cellular, humoral and mucosal immunity

AJ Ramsay, SJ Kent, RA Strugnell, A Suhrbier, SA Thomson, IA Ramshaw

Journal article  |  1999  |  Immunological Reviews

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HIV vaccines - promise and directions

SJ Kent

Conference Proceedings  |  1999  |  Medical Journal of Australia

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Can HIV infection be prevented with a vaccine?

AK Joy, CJ Dale, SJ Kent

Journal article  |  1999  |  Drugs in R & D

The global human immunodeficiency virus type 1 (HIV-1) epidemic is devastating many communities and a well tolerated and effective..

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Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus

SJ Kent, A Zhao, SJ Best, JD Chandler, DB Boyle, IA Ramshaw

Journal article  |  1998  |  Journal of Virology

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Preventive HIV-1 vaccines: where are we going?

SJ Kent

Journal article  |  1998  |  International Journal of STD & AIDS

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Antiviral CD4 cell response in simian immunodeficiency virus-infected macaques - Reply

SJ Kent

Journal article  |  1998  |  Journal of Infectious Diseases

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Antiviral CD4 cell response in simian immunodeficiency virus-infected macaques

U Dittmer, G Hunsmann

Journal article  |  1998  |  The Journal of Infectious Diseases

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A minimally replicative HIV-2 live-virus vaccine protects M-nemestrina from disease after HIV-2(287) challenge

DJ Looney, J McClure, SJ Kent, A Radaelli, G Kraus, A Schmidt, K Steffy, P Greenberg, SL Hu, WR Morton, F Wong-Staal

Journal article  |  1998  |  Virology

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Genetically identical primate modelling systems for HIV vaccines

SJ Kent, IM Lewis

Journal article  |  1998  |  Reproduction, Fertility and Development

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Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses correlate with control of acute HIV-1 infection in macaques

SJ Kent, A Woodward, A Zhao

Journal article  |  1997  |  The Journal of Infectious Diseases

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Lymphoproliferative immune function in the Sydney Blood Bank Cohort, infected with natural nef/long terminal repeat mutants, and in other long-term survivors of transfusion-acquired HIV-1 infection

WB Dyer, AF Geczy, SJ Kent, LB McIntyre, SA Blasdall, JC Learmont, JS Sullivan

Journal article  |  1997  |  AIDS

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Antagonism of vaccine-induced HIV-1-specific CD4( ) T cells by primary HIV-1 infection - Potential mechanism of vaccine failure

SJ Kent, PD Greenberg, MC Hoffman, RE Akridge, MJ McElrath

Journal article  |  1997  |  Journal of Immunology

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Managing HIV .8. Controlling an epidemic .8.3. Prospects for a preventive HIV vaccine

SJ Kent, RL Clancy, GL Ada

Journal article  |  1996  |  Medical Journal of Australia

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Detection of simian immunodeficiency virus (SIV)-specific CD8( ) T cells in macaques protected from SIV challenge by prior SIV subunit vaccination

SJ Kent, SL Hu, L Corey, WR Morton, PD Greenberg

Journal article  |  1996  |  Journal of Virology

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HIV-1 INFECTION OF HUMAN MACROPHAGES IMPAIRS PHAGOCYTOSIS AND KILLING OF TOXOPLASMA-GONDII

BA BIGGS, M HEWISH, S KENT, K HAYES, SM CROWE

Journal article  |  1995  |  Journal of Immunology

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CYTOTOXIC AND PROLIFERATIVE T-CELL RESPONSES IN HIV-1-INFECTED MACACA-NEMESTRINA

SJ KENT, L COREY, MB AGY, WR MORTON, MJ MCELRATH, PD GREENBERG

Journal article  |  1995  |  Journal of Clinical Investigation

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HIV-INFECTION OF MONOCYTE-DERIVED MACROPHAGES IN-VITRO REDUCES PHAGOCYTOSIS OF CANDIDA-ALBICANS

SM CROWE, NJ VARDAXIS, SJ KENT, AL MAERZ, MJ HEWISH, MS MCGRATH, J MILLS

Journal article  |  1994  |  Journal of Leukocyte Biology

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Listeria monocytogenes peritonitis with review of literature.

SJ Kent, MS Van Scoy, S Skerrett

Journal article  |  1994  |  Australian and New Zealand Journal of Medicine

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ANALYSIS OF CYTOTOXIC T-LYMPHOCYTE RESPONSES TO SIV PROTEINS IN SIV-INFECTED MACAQUES USING ANTIGEN-SPECIFIC STIMULATION WITH RECOMBINANT VACCINIA AND FOWL POXVIRUSES

SJ KENT, V STALLARD, L COREY, SL HU, WR MORTON, L GRITZ, DL PANICALI, PD GREENBERG

Journal article  |  1994  |  AIDS Research and Human Retroviruses

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HIV-1 INFECTION OF MONOCYTE-DERIVED MACROPHAGES REDUCES FC AND COMPLEMENT RECEPTOR EXPRESSION

SJ KENT, G STENT, S SONZA, SD HUNTER, SM CROWE

Journal article  |  1994  |  Clinical & Experimental Immunology

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TUBERCULOUS MENINGITIS - A 30-YEAR REVIEW

SJ KENT, SM CROWE, A YUNG, CR LUCAS, AM MIJCH

Journal article  |  1993  |  Clinical Infectious Diseases

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ORAL DAPSONE VERSUS NEBULIZED PENTAMIDINE FOR PNEUMOCYSTIS-CARINII PNEUMONIA PROPHYLAXIS - AN OPEN RANDOMIZED PROSPECTIVE TRIAL TO ASSESS EFFICACY AND HEMATOLOGICAL TOXICITY

MA SLAVIN, JF HOY, K STEWART, MB PETTINGER, CR LUCAS, SJ KENT

Journal article  |  1992  |  AIDS

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INVASIVE ASPERGILLOSIS IN AIDS

CK FAIRLEY, SJ KENT, A STREET, A MIJCH, J HOY

Journal article  |  1991  |  Australian and New Zealand Journal of Medicine

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Scholarly Works

Keyword Analysis

Medical Microbiology
Clinical Health (organs, Diseases and Abnormal Conditions)
Clinical (organs, Diseases and Abnormal Conditions)
Microbiology
Immunology
Expanding Knowledge
Medical Biochemistry and Clinical Chemistry
Nanotechnology
Biochemistry and Cell Biology
Macromolecular and Materials Chemistry

Honours, Awards and Fellowships

2013

Australian Government Citation for University Teaching and Learning
2013

Peter Doherty award for best PhD supervisor, University of Melbourne
2011

Susman Prize for resaerch

Susman Prize, Royal Australasian College of Physicians
2000

Research Excellence award

People Living with HIV/AIDS, Victoria
1997

Glaxo-Wellome (Now Fenner) award for advanced research in Infectious Diseases

Australasian Society for Infectious Diseases
1996

Amgen research award

Australasian Society for HIV Medicine
1992

Harkness fellowship
1991

Research Award, Victorian Division

Royal Australasian College of Physicians
1985

Harriet Power Scholarship Prize in final year medical school

Alfred Hospital
1993

FRACP - Fellow of the Royal Australasian College of Physicians

10

Awards

Credentials

Positions

Professorial Fellow

Microbiology And Immunology

Member

National Association of Research Fellows

Member

American Society of Microbiology

Member

International AIDS Society

Member

Australasian Society for HIV Medicine

Member

Australasian Society for Infectious Diseases

Member

Royal Australasian College of Physicians

Education

Doctor of Medicine

Monash University

Bachelor of Medicine & Bachelor of Surgery

Monash University

Links