Stephen Kent

Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19.

Adam K Wheatley, Jennifer A Juno, Jing J Wang, Kevin J Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Hannah G Kelly, Robyn Esterbauer, Samantha K Davis, Helen E Kent, Francesca L Mordant, Timothy E Schlub, David L Gordon, David S Khoury, Kanta Subbarao, Deborah Cromer, Tom P Gordon, Amy W Chung, et al.

Journal article  |  2021  |  Nature Communications

The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Here, we s..

CD73( ) CD127(high) Long-Term Memory CD4 T Cells Are Highly Proliferative in Response to Recall Antigens and Are Early Targets in HIV-1 Infection

Nabila Seddiki, John Zaunders, Chan Phetsouphanh, Vedran Brezar, Yin Xu, Helen M McGuire, Michelle Bailey, Kristin McBride, Will Hey-Cunningham, Cynthia Mee Ling Munier, Laura Cook, Stephen Kent, Andrew Lloyd, Barbara Cameron, Barbara Fazekas de St Groth, Kersten Koelsch, Mark Danta, Hakim Hocini, Yves Levy, Anthony D Kelleher

Journal article  |  2021  |  International Journal of Molecular Sciences

HIV-1 infection rapidly leads to a loss of the proliferative response of memory CD4+ T lymphocytes, when cultured with recall anti..

Mucosal IL-4R antagonist HIV vaccination with SOSIP-gp140 booster can induce high-quality cytotoxic CD4( )/CD8( ) T cells and humoral responses in macaques

Z Li, M Khanna, SL Grimley, P Ellenberg, CA Gonelli, Wen Shi Lee, TH Amarasena, AD Kelleher, DFJ Purcell, SJ Kent, C Ranasinghe

Journal article  |  2020  |  Scientific Reports

Inducing humoral, cellular and mucosal immunity is likely to improve the effectiveness of HIV-1 vaccine strategies. Here, we teste..

Person-Specific Biomolecular Coronas Modulate Nanoparticle Interactions with Immune Cells in Human Blood

Yi Ju, Hannah G Kelly, Laura F Dagley, Arnold Reynaldi, Timothy E Schlub, Sukhdeep K Spall, Craig A Bell, Jiwei Cui, Andrew J Mitchell, Zhixing Lin, Adam K Wheatley, Kristofer J Thurecht, Miles P Davenport, Andrew Webb, Frank Caruso, Stephen J Kent

Journal article  |  2020  |  ACS Nano

When nanoparticles interact with human blood, a multitude of plasma components adsorb onto the surface of the nanoparticles, formi..

Aggregation by peptide conjugation rescues poor immunogenicity of the HA stem

Wenbo Jiang, Emily H Pilkington, Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Adam K Wheatley, Stephen J Kent

Journal article  |  2020  |  PLoS One

Influenza virus infection is a global public health threat. Current seasonal influenza vaccines are efficacious only when vaccine ..

Measuring immunity to SARS-CoV-2 infection: comparing assays and animal models

David S Khoury, Adam K Wheatley, Mitchell D Ramuta, Arnold Reynaldi, Deborah Cromer, Kanta Subbarao, David H O'Connor, Stephen J Kent, Miles P Davenport

Journal article  |  2020  |  Nature Reviews Immunology

The rapid scale-up of research on coronavirus disease 2019 (COVID-19) has spawned a large number of potential vaccines and immunot..

Controlling the Biological Fate of Micellar Nanoparticles: Balancing Stealth and Targeting

Amal J Sivaram, Andri Wardiana, Sheilajen Alcantara, Stefan E Sonderegger, Nicholas L Fletcher, Zachary H Houston, Christopher B Howard, Stephen M Mahler, Cameron Alexander, Stephen J Kent, Craig A Bell, Kristofer J Thurecht

Journal article  |  2020  |  ACS Nano

Integrating nanomaterials with biological entities has led to the development of diagnostic tools and biotechnology-derived therap..

Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences

Sheila Patel, Jennifer Juno, Wen Shi Lee, Kathleen Wragg, Mark Hogarth, Stephen Kent, Louise Burrell

Journal article  |  2020

COVID-19 causes persistent endothelial inflammation, lung and cardiovascular complications. SARS-CoV-2 utilises the catalytic site..

Suboptimal SARS-CoV-2-specific CD8( ) T cell response associated with the prominent HLA-A*02:01 phenotype

Jennifer R Habel, Thi HO Nguyen, Carolien E van de Sandt, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L Flanagan, Denise L Doolan, Joseph Torresi, Weisan Chen, Linda M Wakim, Allen C Cheng, Peter C Doherty, Jan Petersen, et al.

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of USA

An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

Wen Shi Lee, Adam K Wheatley, Stephen J Kent, Brandon J DeKosky

Journal article  |  2020  |  Nature Microbiology

Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expedited through..