Mark Rizzacasa

Total Synthesis of ( )-Trachyspic Acid 19-n-Butyl Ester.

Alex A Rafaniello, Mark A Rizzacasa

Journal article  |  2020  |  Organic Letters

The first total synthesis of the alkyl citrate trachyspic acid 19-n-butyl ester (1) is described. A formal [2 + 2]-cycloaddition o..

Frontispiece: The Nargenicin Family of Oxa‐Bridged Macrolide Antibiotics

Sacha J Pidot, Mark A Rizzacasa

Journal article  |  2020  |  Chemistry – A European Journal

The Nargenicin Family of Oxa-Bridged Macrolide Antibiotics

Sacha J Pidot, Mark A Rizzacasa

Journal article  |  2019  |  Chemistry – A European Journal

The nargenicin family of antibiotic macrolides comprise a group of bacterial natural products with a rare ether bridged cis-decali..

Total Synthesis and Stereochemical Reassignment of Citrafungin A

Zongjia Chen, Angus Robertson, Jonathan M White, Mark A Rizzacasa

Journal article  |  2019  |  Organic Letters

The stereoselective 12-step total synthesis of the reassigned structure for citrafungin A (1a) via cyclobutene diester 10 is descr..

An effective cis-beta-octahedral Mn(iii) SALPN catalyst for the Mukaiyama-Isayama hydration of alpha,beta-unsaturated esters

Paul S Donnelly, Andrea J North, Natalia Caren Radjah, Michael Ricca, Angus Robertson, Jonathan M White, Mark A Rizzacasa

Journal article  |  2019  |  Chemical Communications

Biosynthesis and Ether-Bridge Formation in Nargenicin Macrolides

Sacha J Pidot, Marion Herisse, Liam Sharkey, Liselle Atkin, Jessica L Porter, Torsten Seemann, Benjamin P Howden, Mark A Rizzacasa, Timothy P Stinear

Journal article  |  2019  |  Angewandte Chemie International Edition

Biosynthesis and Ether‐Bridge Formation in Nargenicin Macrolides

Sacha J Pidot, Marion Herisse, Liam Sharkey, Liselle Atkin, Jessica L Porter, Torsten Seemann, Benjamin P Howden, Mark A Rizzacasa, Timothy P Stinear

Journal article  |  2019  |  Angewandte Chemie

The nargenicin family of antibiotics are macrolides containing a rare ether‐bridged cis‐decalin motif. Several of these compounds ..

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and-7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1 beta Activation

James E Vince, Dominic De Nardo, Wenqing Gao, Angelina J Vince, Cathrine Hall, Kate McArthur, Daniel Simpson, Swarna Vijayaraj, Lisa M Lindqvist, Philippe Bouillet, Mark A Rizzacasa, Si Ming Man, John Silke, Seth L Masters, Guillaume Lessene, David CS Huang, Daniel HD Gray, Benjamin T Kile, Feng Shao, Kate E Lawlor

Journal article  |  2018  |  Cell Reports

Synthesis of Alkyl Citrates (-)-CJ-13,981, (-)-CJ-13,982, and (-)-L-731,120 via a Cyclobutene Diester

Liselle Atkin, Zongjia Chen, Angus Robertson, Dayna Sturgess, Jonathan M White, Mark A Rizzacasa

Journal article  |  2018  |  Organic Letters

A four step synthesis of violaceic acid

Alex Cameron, Brendan Fisher, Mark A Rizzacasa

Journal article  |  2018  |  Tetrahedron

Enantiospecific total synthesis of the squalene synthase inhibitors (-)-CJ-13,982 and its enantiomer from a common intermediate

Dayna Sturgess, Zongjia Chen, Jonathan M White, Mark A Rizzacasa

Journal article  |  2018  |  The Journal of Antibiotics

An unprecedented stereoselective base-induced trimerization of an alpha-bromovinylsulfone

Brendan Fisher, Romain J Lepage, Jonathan M White, Young Ye, Elizabeth H Krenske, Mark A Rizzacasa

Journal article  |  2017  |  Organic & Biomolecular Chemistry

Synthesis of Homochiral Co-III- and Mn-IV-[2.2]Paracyclophane Schiff Base Complexes with Predetermined Chirality at the Metal Centre

Darran Loits, Stefan Braese, Andrea J North, Jonathan M White, Paul S Donnelly, Mark A Rizzacasa

Journal article  |  2016  |  European Journal of Inorganic Chemistry

Total synthesis of a biotinylated rocaglate: Selective targeting of the translation factors eIF4AI/II

Jennifer M Chambers, Lisa M Lindqvist, G Paul Savage, Mark A Rizzacasa

Journal article  |  2016  |  Bioorganic & Medicinal Chemistry Letters

Macrolactam analogues of macrolide natural products

Helmut M Hugel, Andrew T Smith, Mark A Rizzacasa

Journal article  |  2016  |  Organic & Biomolecular Chemistry

Towards the Synthesis of Dihydrooxepino[4,3-b]pyrrole-Containing Natural Products via Cope Rearrangement of Vinyl Pyrrole Epoxides

Alex Cameron, Brendan Fisher, Nicholas Fisk, Jessica Hummel, Jonathan M White, Elizabeth H Krenske, Mark A Rizzacasa

Journal article  |  2015  |  Organic Letters

Resolvin D2 Supports MCF-7 Cell Proliferation via Activation of Estrogen Receptor

Nuha Al-Zaubai, Cameron N Johnstone, May May Leong, John Li, Mark Rizzacasa, Alastair G Stewart

Journal article  |  2014  |  Journal of Pharmacology and Experimental Therapeutics

Simplified Silvestrol Analogues with Potent Cytotoxic Activity

Bill C Hawkins, Lisa M Lindqvist, Nhu Duong, Phillip P Sharp, David Segal, Andrew K Powell, Michael Campbell, Eileen Ryan, Jennifer M Chambers, Jonathan M White, Mark A Rizzacasa, Guillaume Lessene, David CS Huang, Christopher J Burns

Journal article  |  2014  |  ChemMedChem

Synthesis of the C1-C18 Fragment of Rhizopodin: Late-State Introduction of the Oxazole

Tobias Bender, Darran Loits, Jonathan M White, Mark A Rizzacasa

Journal article  |  2014  |  Organic Letters

Total synthesis of alkyl citrate natural products

Mark A Rizzacasa, Dayna Sturgess

Journal article  |  2014  |  Organic & Biomolecular Chemistry

Total synthesis of the endogenous inflammation resolving lipid resolvin D2 using a common lynchpin

John Li, May May Leong, Alastair Stewart, Mark A Rizzacasa

Journal article  |  2013  |  Beilstein Journal of Organic Chemistry

Synthesis of Biotinylated Episilvestrol: Highly Selective Targeting of the Translation Factors eIF4AI/II

Jennifer M Chambers, Lisa M Lindqvist, Andrew Webb, David CS Huang, G Paul Savage, Mark A Rizzacasa

Journal article  |  2013  |  Organic Letters

Formal Total Synthesis of Spirangien A

Claire Gregg, Christian Gunawan, Audrey Wei Yi Ng, Samantha Wimala, Sonali Wickremasinghe, Mark A Rizzacasa

Journal article  |  2013  |  Organic Letters

Total Synthesis of the Proposed Structure of 8-Deshydroxyajudazol A: A Modified Approach to 2,4-Disubstituted Oxazoles

Stephen Birkett, Danny Ganame, Bill C Hawkins, Sebastien Meiries, Tim Quach, Mark A Rizzacasa

Journal article  |  2013  |  Journal of Organic Chemistry

Synthesis and biological evaluation of a potent salicylihalamide A lactam analogue

Dan Balan, Christopher J Burns, Nicholas G Fisk, Helmut Huegel, David CS Huang, David Segal, Charlotte White, Joerg Wagler, Mark A Rizzacasa

Journal article  |  2012  |  Organic & Biomolecular Chemistry

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

LM Lindqvist, I Vikstroem, JM Chambers, K McArthur, M Ann Anderson, KJ Henley, L Happo, L Cluse, RW Johnstone, AW Roberts, BT Kile, BA Croker, CJ Burns, MA Rizzacasa, A Strasser, DCS Huang

Journal article  |  2012  |  Cell Death & Disease

Total Synthesis of 2 ''',5 '''-Diepisilvestrol and Its C1 ''' Epimer: Key Structure Activity Relationships at C1 ''' and C2 '''

Jennifer M Chambers, David CS Huang, Lisa M Lindqvist, G Paul Savage, Jonathan M White, Mark A Rizzacasa

Journal article  |  2012  |  Journal of Natural Products

Synthesis of myxobacteria metabolites

Stephen L Birkett, Darran A Loits, Samantha Wimala, Mark A Rizzacasa

Journal article  |  2012  |  Pure and Applied Chemistry

Synthetic studies towards the mulberry Diels-Alder adducts: H-bond accelerated cycloadditions of chalcones

Sompong Boonsri, Christian Gunawan, Elizabeth H Krenske, Mark A Rizzacasa

Journal article  |  2012  |  Organic & Biomolecular Chemistry

SYNTHESIS OF NOVEL OLIGOSACCHARIDES BASED ON 1,4-DIOXANYLOXY 3-OXASUGARS

Margaret Morozova, Sonali Wickremasinghe, Mark A Rizzacasa

Journal article  |  2012  |  Heterocycles

Formal total synthesis of the myxobacteria metabolite apicularen A via a transannular oxy-Michael addition

Ferdows Hilli, Jonathan M White, Mark A Rizzacasa

Journal article  |  2011  |  Tetrahedron

Total Synthesis of 8-Deshydroxyajudazol B

Stephen Birkett, Danny Ganame, Bill C Hawkins, Sebastien Meiries, Tim Quach, Mark A Rizzacasa

Journal article  |  2011  |  Organic Letters

Stereoselective Total Synthesis of (-)-Spirofungin A by Utilising Hydrogen-Bond Controlled Spiroketalisation

John E Lynch, Shannon D Zanatta, Jonathan M White, Mark A Rizzacasa

Journal article  |  2011  |  Chemistry - A European Journal

Total Synthesis of (-)-Reveromycin A via a Hetero-Diels-Alder Approach

Mariana El Sous, Danny Ganame, Peter Tregloan, Mark A Rizzacasa

Journal article  |  2010  |  Synthesis

Mulberry Diels-Alder Adducts: Synthesis of Chalcomoracin and Mulberrofuran C Methyl Ethers

Christian Gunawan, Mark A Rizzacasa

Journal article  |  2010  |  Organic Letters

Total Synthesis of the Potent Anticancer Aglaia Metabolites (-)-Silvestrol and (-)-Episilvestrol and the Active Analogue (-)-4 '-Desmethoxyepisilvestrol

Tim E Adams, Mariana El Sous, Bill C Hawkins, Sebastian Hirner, Georgina Holloway, Mui Ling Khoo, David J Owen, G Paul Savage, Peter J Scammells, Mark A Rizzacasa

Journal article  |  2009  |  Journal of the American Chemical Society

The hetero-Diels-Alder approach to spiroketals

Mark A Rizzacasa, Annett Pollex

Journal article  |  2009  |  Organic & Biomolecular Chemistry

Formal Total Synthesis of ( )-Citrafungin A

Sammi Tsegay, Helmut Huegel, Mark A Rizzacasa

Journal article  |  2009  |  Australian Journal of Chemistry

Asymmetric total synthesis of the myxobacteria metabolites crocacins A-D

John T Feutrill, Michael J Lilly, Jonathan M White, Mark A Rizzacasa

Journal article  |  2008  |  Tetrahedron

Synthesis of the C9-C29 fragments of ajudazols A and B

Danny Ganame, Tim Quach, Charlotte Poole, Mark A Rizzacasa

Journal article  |  2007  |  Tetrahedron Letters

Enantiospecific synthesis of the heparanase inhibitor ( )-trachyspic acid and stereoisomers from a common precursor

Steven C Zammit, Vito Ferro, Edward Hammond, Mark A Rizzacasa

Journal article  |  2007  |  Organic & Biomolecular Chemistry

Total synthesis of (-)-episilvestrol and (-)-silvestrol

Mariana El Sous, Mui Ling Khoo, Georgina Holloway, David Owen, Peter J Scammells, Mark A Rizzacasa

Journal article  |  2007  |  Angewandte Chemie - International Edition

Formal total synthesis of ( )-zaragozic acid C through an Ireland-Claisen rearrangement

Jens O Bunte, Anthony N Cuzzupe, Alica M Daly, Mark A Rizzacasa

Journal article  |  2006  |  Angewandte Chemie - International Edition

Total synthesis of spiroketal containing natural products: kinetic vs. thermodynamic approaches

Mariana El Sous, Danny Ganame, Shannon Zanatta, Mark A Rizzacasa

Journal article  |  2006  |  Arkivoc

Autoxidation of salvinorin A under basic conditions

TA Munro, GW Goetchius, BL Roth, TA Vortherms, MA Rizzacasa

Journal article  |  2005  |  Journal of Organic Chemistry

Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist

TA Munro, MA Rizzacasa, BL Roth, BA Toth, F Yan

Journal article  |  2005  |  Journal of Medicinal Chemistry

Biomimetic synthesis of the novel 1,4-dioxanyloxy fragment of silvestrol and episilvestrol

M El Sous, MA Rizzacasa

Journal article  |  2005  |  Tetrahedron Letters

Enantiospecific synthesis of (-)-trachyspic acid

SC Zammit, JM White, MA Rizzacasa

Journal article  |  2005  |  Organic & Biomolecular Chemistry

Total synthesis of (-)-reveromycin A

M El Sous, D Ganame, PA Tregloan, MA Rizzacasa

Journal article  |  2004  |  Organic Letters

Formal total synthesis of (-)-apicularen a via transannular conjugate addition

F Hilli, JM White, MA Rizzacasa

Journal article  |  2004  |  Organic Letters

Total synthesis of the proposed structure for spirofungin B: A reassignment of the stereochemistry

SD Zanatta, JM White, MA Rizzacasa

Journal article  |  2004  |  Organic Letters

Characterisation of nickel(II) extraction by 2-hydroxy-5-nonylacetophenone oxime (LIX 84) in a micellar phase

DB Warren, G Dyson, F Grieser, JM Perera, GW Stevens, MA Rizzacasa

Journal article  |  2003  |  Colloids and Surfaces A: Physicochemical and Engineering Aspects

Divinatorins A-C, new neoclerodane diterpenoids from the controlled sage Salvia divinorum

AK Bigham, TA Munro, MA Rizzacasa, RM Robins-Browne

Journal article  |  2003  |  Journal of Natural Products

Salvinorins D-F, new neoclerodane diterpenoids from Salvia divinorum, and an improved method for the isolation of salvinorin A

TA Munro, MA Rizzacasa

Journal article  |  2003  |  Journal of Natural Products

Formal total synthesis of salicylihalamides A and B

GA Holloway, HM Hugel, MA Rizzacasa

Journal article  |  2003  |  Journal of Organic Chemistry

Enantiospecific synthesis of the phospholipase A(2) inhibitors (-)-cinatrin C-1 and ( )-cinatrin C-3

AN Cuzzupe, R Di Florio, JM White, MA Rizzacasa

Journal article  |  2003  |  Organic & Biomolecular Chemistry

Total synthesis of ( )-crocacin A

JT Feutrill, MA Rizzacasa

Journal article  |  2003  |  Australian Journal of Chemistry

Total synthesis of the marine sponge metabolites ( )-rottnestol, ( )-raspailol A and ( )-raspailol B

IR Czuba, S Zammit, MA Rizzacasa

Journal article  |  2003  |  Organic & Biomolecular Chemistry

Synthesis of the core of apicularen A by transannular conjugate addition

F Hilli, JM White, MA Rizzacasa

Journal article  |  2002  |  Tetrahedron Letters

Enantiospecific synthesis of the phospholipase A(2) inhibitor (-)-cinatrin B

AN Cuzzupe, R Di Florio, MA Rizzacasa

Journal article  |  2002  |  Journal of Organic Chemistry

Total synthesis of ( )-crocacin D

JT Feutrill, MJ Lilly, MA Rizzacasa

Journal article  |  2002  |  Organic Letters

Total synthesis of the epidermal growth factor inhibitor (-)-reveromycin B

AN Cuzzupe, CA Hutton, MJ Lilly, RK Mann, KJ McRae, SC Zammit, MA Rizzacasa

Journal article  |  2001  |  Journal of Organic Chemistry

Synthetic studies on the salicylihalamides: macrolactone formation via ring closing metathesis versus macrolactonization

JT Feutrill, GA Holloway, F Hilli, HM Hugel, MA Rizzacasa

Journal article  |  2000  |  Tetrahedron Letters

Hetero-Diels-Alder synthesis of the spiroketal fragment of reveromycin A

M El Sous, MA Rizzacasa

Journal article  |  2000  |  Tetrahedron Letters

Total synthesis of ( )-crocacin C

JT Feutrill, MJ Lilly, MA Rizzacasa

Journal article  |  2000  |  Organic Letters

Total synthesis of (-)-reveromycin B

AN Cuzzupe, CA Hutton, MJ Lilly, RK Mann, MA Rizzacasa, SC Zammit

Journal article  |  2000  |  Organic Letters

Synthesis of the syributins and formal total synthesis of syringolide 1

R Di Florio, MA Rizzacasa

Journal article  |  2000  |  Australian Journal of Chemistry

Total synthesis of ( )-rottnestol

IR Czuba, MA Rizzacasa

Journal article  |  1999  |  Chemical Communications

Synthesis of 2,2-disubstituted furanoid natural products: Total synthesis of sphydrofuran

R Di Florio, MA Rizzacasa

Journal article  |  1998  |  The Journal of Organic Chemistry

Towards the synthesis of the squalestatins/zaragozic acids: Synthesis of an advanced intermediate and introduction of the C-1 sidechain

RK Mann, JG Parsons, MA Rizzacasa

Journal article  |  1998  |  Journal of the Chemical Society, Perkin Transactions 1

Total synthesis of naphthylisoquinoline alkaloids

MA Rizzacasa

Journal article  |  1997  |  Studies in Natural Products Chemistry

Synthetic studies toward the reveromycins: Asymmetric synthesis of the spiroketal segment of reveromycin B

KJ McRae, MA Rizzacasa

Journal article  |  1997  |  The Journal of Organic Chemistry

Convergent synthesis of naphthylisoquinoline alkaloids: Total synthesis of ( )-O-methylancistrocline

P Chau, IR Czuba, MA Rizzacasa, G Bringmann, KP Gulden, M Schaffer

Journal article  |  1996  |  The Journal of Organic Chemistry

FORMAL SYNTHESIS OF (-)-O-METHYLANCISTROCLADINE

BN LEIGHTON, MA RIZZACASA

Journal article  |  1995  |  The Journal of Organic Chemistry

A synthetic approach to ( )-dioncophylline C

RW Gable, RL Martin, MA Rizzacasa

Journal article  |  1995  |  Australian Journal of Chemistry

SYNTHESIS OF THE C-1 SIDE-CHAIN OF THE SQUALESTATINS AND ZARAGOZIC ACID-A

JG PARSONS, MA RIZZACASA

Journal article  |  1994  |  Tetrahedron Letters

SYNTHETIC STUDIES TOWARDS THE SQUALESTATINS AND ZARAGOZIC ACIDS

LM MCVINISH, MA RIZZACASA

Journal article  |  1994  |  Tetrahedron Letters

CONVERGENT SYNTHESIS OF POLYETHER IONOPHORE ANTIBIOTICS - SYNTHESIS OF THE SPIROKETAL AND TRICYCLIC GLYCAL SEGMENTS OF MONENSIN

RE IRELAND, JD ARMSTRONG, J LEBRETON, RS MEISSNER, MA RIZZACASA

Journal article  |  1993  |  Journal of the American Chemical Society

CONVERGENT SYNTHESIS OF POLYETHER IONOPHORE ANTIBIOTICS - PROTECTIVE MANIPULATION AND SYNTHESIS OF MONENSIN-A

RE IRELAND, RS MEISSNER, MA RIZZACASA

Journal article  |  1993  |  Journal of the American Chemical Society

SYNTHETIC APPROACHES TO THE ALKALOIDS OF THE ANCISTROCLADACEAE .3. THE TOTAL SYNTHESIS OF (-)-ANCISTROCLADININE - CONTROL OF THE DIASTEREOISOMER EXCESS IN THE SYNTHESIS OF AXIALLY CHIRAL BIARYLS

MA RIZZACASA, MV SARGENT

Journal article  |  1991  |  J. Chem. Soc., Perkin Trans. 1

SYNTHETIC APPROACHES TO THE NAPHTHYL-ISOQUINOLINE ALKALOIDS .1. DEHYDROANCISTROCLADISINE

MA RIZZACASA, MV SARGENT

Journal article  |  1991  |  Journal of the Chemical Society, Perkin Transactions 1

SYNTHETIC APPROACHES TO THE NAPHTHYL-ISOQUINOLINE ALKALOIDS .2. THE TOTAL SYNTHESIS OF (-)-O-METHYLANCISTROCLADINE AND ( )-O-METHYLHAMATINE AND THEIR ENANTIOMERS

MA RIZZACASA, MV SARGENT

Journal article  |  1991  |  J. Chem. Soc., Perkin Trans. 1

SYNTHETIC APPROACHES TO THE ALKALOIDS OF THE ANCISTROCLADACEAE - CONTROL OF THE DIASTEREOISOMER EXCESS IN THE SYNTHESIS OF AXIALLY CHIRAL BIARYLS - A SYNTHESIS OF (-)-ANCISTROCLADININE

MA RIZZACASA, MV SARGENT

Journal article  |  1991  |  J. Chem. Soc., Chem. Commun.

SYNTHETIC APPROACHES TO THE ALKALOIDS OF THE ANCISTROCLADACEAE - (-)-O-METHYLANCISTROCLADINE AND ( )-O-METHYLHAMATINE

MA RIZZACASA, MV SARGENT

Journal article  |  1990  |  J. Chem. Soc., Chem. Commun.

THE STEREOISOMERS OF 5-BROMO-6,8-DIMETHOXY-1,2,3-TRIMETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE - X-RAY CRYSTAL-STRUCTURE OF THE TRANS-ISOMER

MA RIZZACASA, MV SARGENT, BW SKELTON, AH WHITE

Journal article  |  1990  |  Australian Journal of Chemistry

SYNTHETIC APPROACHES TO THE ALKALOIDS OF THE ANCISTROCLADACEA - DEHYDROANCISTROCLADISINE

M RIZZACASA, MV SARGENT

Journal article  |  1989  |  Journal of the Chemical Society, Chemical Communications

THE SYNTHESIS OF DESERTORIN-C, A BICOUMARIN FROM THE FUNGUS EMERICELLA-DESERTORUM

MA RIZZACASA, MV SARGENT

Journal article  |  1988  |  Journal of the Chemical Society, Perkin Transactions 1

THE SYNTHESIS OF STYPANDROL, A TOXIC BINAPHTHALENETETROL ISOLATED FROM STYPANDRA-IMBRICATA - NEW SYNTHESES OF DIANELLIDIN AND STYPANDRONE

MA RIZZACASA, MV SARGENT

Journal article  |  1988  |  Australian Journal of Chemistry

THE STRUCTURE AND SYNTHESIS OF NEPENTHONE-A, A NAPHTHOQUINONE FROM NEPENTHES-RAFFLESIANA

MA RIZZACASA, MV SARGENT

Journal article  |  1987  |  Journal of the Chemical Society, Perkin Transactions 1

THE WITTIG REACTION OF 2-TERT-BUTOXYCARBONYL-1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE - A SURROGATE FOR THE STOBBE REACTION

MA RIZZACASA, MV SARGENT

Journal article  |  1987  |  Australian Journal of Chemistry