Mark Rizzacasa

2019 highlights of the structural revision of natural product via total synthesis

Zongjia Chen, Mark A Rizzacasa

Journal article  |  2020  |  Frontiers of Chemical Science and Engineering

Total Synthesis of ( )-Trachyspic Acid 19-n-Butyl Ester

Alex A Rafaniello, Mark A Rizzacasa

Journal article  |  2020  |  Organic Letters

The first total synthesis of the alkyl citrate trachyspic acid 19-n-butyl ester (1) is described. A formal [2 + 2]-cycloaddition o..

Frontispiece: The Nargenicin Family of Oxa‐Bridged Macrolide Antibiotics

Sacha J Pidot, Mark A Rizzacasa

Journal article  |  2020  |  Chemistry - A European Journal

The Nargenicin Family of Oxa-Bridged Macrolide Antibiotics

Sacha J Pidot, Mark A Rizzacasa

Journal article  |  2019  |  Chemistry – A European Journal

The nargenicin family of antibiotic macrolides comprise a group of bacterial natural products with a rare ether bridged cis-decali..

Total Synthesis and Stereochemical Reassignment of Citrafungin A

Zongjia Chen, Angus Robertson, Jonathan M White, Mark A Rizzacasa

Journal article  |  2019  |  Organic Letters

The stereoselective 12-step total synthesis of the reassigned structure for citrafungin A (1a) via cyclobutene diester 10 is descr..

An effective cis-beta-octahedral Mn(iii) SALPN catalyst for the Mukaiyama-Isayama hydration of alpha,beta-unsaturated esters

Paul S Donnelly, Andrea J North, Natalia Caren Radjah, Michael Ricca, Angus Robertson, Jonathan M White, Mark A Rizzacasa

Journal article  |  2019  |  Chemical Communications

Biosynthesis and Ether-Bridge Formation in Nargenicin Macrolides

Sacha J Pidot, Marion Herisse, Liam Sharkey, Liselle Atkin, Jessica L Porter, Torsten Seemann, Benjamin P Howden, Mark A Rizzacasa, Timothy P Stinear

Journal article  |  2019  |  Angewandte Chemie International Edition

Biosynthesis and Ether‐Bridge Formation in Nargenicin Macrolides

Sacha J Pidot, Marion Herisse, Liam Sharkey, Liselle Atkin, Jessica L Porter, Torsten Seemann, Benjamin P Howden, Mark A Rizzacasa, Timothy P Stinear

Journal article  |  2019  |  Angewandte Chemie

Abstract: The nargenicin family of antibiotics are macrolides containing a rare ether‐bridged cis‐decalin motif. Several of these ..

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and-7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1 beta Activation

James E Vince, Dominic De Nardo, Wenqing Gao, Angelina J Vince, Cathrine Hall, Kate McArthur, Daniel Simpson, Swarna Vijayaraj, Lisa M Lindqvist, Philippe Bouillet, Mark A Rizzacasa, Si Ming Man, John Silke, Seth L Masters, Guillaume Lessene, David CS Huang, Daniel HD Gray, Benjamin T Kile, Feng Shao, Kate E Lawlor

Journal article  |  2018  |  Cell Reports

Synthesis of Alkyl Citrates (-)-CJ-13,981, (-)-CJ-13,982, and (-)-L-731,120 via a Cyclobutene Diester

Liselle Atkin, Zongjia Chen, Angus Robertson, Dayna Sturgess, Jonathan M White, Mark A Rizzacasa

Journal article  |  2018  |  Organic Letters

An efficient and step-economic new approach to alkyl citrate natural products from a cyclobutene diester is presented. The key seq..