Professor Angus has been an Honorary Professorial Fellow and Professor Emeritus of the Department of Pharmacology and Therapeutics, Faculty of Medicine, Dentistry and Health Sciences at the University of Melbourne since 2014. From 2003 to 2013, Prof. Angus was Dean of the Faculty of Medicine, Dentistry and Health Sciences.Prof.
Angus earned a Bachelor of Science in pharmacology with Honours and a Ph.D. from the University of Sydney. In 1974, he was a NHMRC Senior Research Officer at the Hallstrom Institute of Cardiology, Royal Prince Alfred Hospital & Department of Medicine at the University of Sydney, and the Baker Medical Research Institute in Prahran, Victoria. In 1977 he received the NHMRC CJ Martin Travelling Fellowship to work with Sir James Black who would go on to receive the Nobel Prize for Medicine in 1988. Prof. Angus then continued to work at the Baker Medical Research Institute in a variety of roles over the next 15 years including Senior Research Officer, Research Fellow, Senior Research Fellow, Principal Research Fellow, and Senior Principal Research Fellow of the NHMRC. He was appointed Deputy Director of the Baker Medical Research Institute in 1992. In 1993, Prof. Angus was appointed to the Chair of Pharmacology at the University of Melbourne until he resigned in 2003 to become Dean of the Faculty.His appointments include Chair of the Melbourne Genomics Health Alliance Phase 1 (2014-2016), Governor and Director of the Howard Florey Institute of Neuroscience and Mental Health since 2003, member of the Program Steering Committee of the Australian Council of Learned Academies (2014-2016), member of the Steering Committee to establish the Australian Academy of Health and Medical Sciences (2013-2014), current President of the National Stroke Foundation, current Chair of the University of Melbourne Sport Board, current Board Director of the Jack Brockhoff Foundation since 2015 and current Chair of the Australian Advisory Council on Medicinal Use of Cannabis.Prof. Angus is a Fellow and former Council Member of the Australian Academy of Science as well as the International Academy of Cardiovascular Sciences, and an Honorary Fellow of the Australian Academy of Health and Medical Sciences. Over the past 25 years, he has received numerous research grants from such learned institutions and organizations as the NHMRC, Australian College of Anaesthetists, National Heart Foundation of Australia, Glaxo Smith Kline Pty Ltd and Johnson & Johnson Pty Ltd.His scientific society memberships include the Australian Physiological and Pharmacology Society, Australian Society for Clinical and Experimental Pharmacology, British Pharmacological Society, Cardiac Society of Australia and New Zealand, High Blood Pressure Research Council of Australia, International Society for Heart Research, International Society of Autonomic Neuroscience and International Union of Pharmacology, of which he was first Vice President (2002-2006).He was the recipient of the Alfred Gottschalk Medal of the Australian Academy of Science in 1984, and the Thomson ISI: Australian Citation Laureate in Pharmacology in 2004. In 2010, Prof. Angus was appointed an Officer to The Order of Australia for distinguished service to biomedical research, particularly in the fields of pharmacology and cardiovascular disease, as a leading academic and medical educator, and as a contributor to a range of advisory boards and professional organisations both nationally and internationally. Further, he received the Centenary Medal in 2003 for services to pharmacology and the community. His current research interests are in analytical pharmacology, cardiovascular effects of endothelin and selective antagonists, and determining mechanisms of action of various medicinal cannabis products.
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James Angus' selected work
Estimation of the vascular resistance amplifier in the renal vascular bed in conscious hyp..
The effects of varying Mg2 ion concentrations on contractions to the cotransmitters ATP an..
Australian Rotary Health Research Fund-9800 Ms Awareness Committee Ms Scholarship 2004 To ..
Displaying the 4 most recent projects by James Angus.
Displaying the 270 most recent scholarly works by James Angus.
The β2-adrenoceptor agonist bronchodilators terbutaline and orciprenaline are also weak α1-adrenoceptor antagonists.
Makhala M Khammy, Cindy Kha Han Truong, Christine E Wright, James A Angus
Journal article | 2020 | European Journal of Pharmacology
Recently, the β2-adrenoceptor agonist terbutaline was shown to have α1-adrenolytic activity in mouse isolated pulmonary arteries i..
The effects of varying Mg2 ion concentrations on contractions to the cotransmitters ATP and noradrenaline in the rat vas deferens
Amna C Mazeh, James A Angus, Christine E Wright
Journal article | 2019 | Autonomic Neuroscience
The vas deferens responds to a single electrical pulse with a biphasic contraction caused by cotransmitters ATP and noradrenaline...
Tandem free-radical addition/substitution chemistry and its application to the preparation of novel AT(1) receptor antagonists
Maree K Staples, Rebecca L Grange, James A Angus, James Ziogas, Nichole PH Tan, Michelle K Taylor, Carl H Schiesser
Journal article | 2011 | Organic & Biomolecular Chemistry
Synthesis and cannabinoid activity of 1-sub stituted-indole-3-oxadiazole derivatives: Novel agonists for the CB1 receptor
Gerard P Moloney, James A Angus, Alan D Robertson, Martin J Stoermer, Michael Robinson, Christine E Wright, Ken McRae, Arthur Christopoulos
Journal article | 2008 | European Journal of Medicinal Chemistry
Synthesis and cannabinoid activity of a variety of 2,3-substituted 1-benzo[b]thiophen derivatives and 2,3-substituted benzofuran: Novel agonists for the CB1 receptor
Gerard P Moloney, James A Angus, Alan D Robertson, Martin J Stoermer, Michael Robinson, Lucy Lay, Christine E Wright, Ken McRae, Arthur Christopoulos
Journal article | 2008 | Australian Journal of Chemistry
Adaptation of the Folts and electrolytic methods of arterial thrombosis for the study of anti-thrombotic molecules in small animals.
Sharelle A Sturgeon, Catherine Jones, James A Angus, Christine E Wright
Journal article | 2006 | Journal of Pharmacological and Toxicological Methods
INTRODUCTION: Animal preparations of arterial thrombosis play a crucial role in the discovery and validation of novel drug targets..
Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: Effects in human, rat and guinea-pig tissues in vitro and in pigs in vivo
KD Winkel, J Tibballs, P Molenaar, G Lambert, P Coles, M Ross-Smith, C Wiltshire, PJ Fenner, LA Gershwin, GM Hawdon, CE Wright, JA Angus
Journal article | 2005 | Clinical and Experimental Pharmacology and Physiology
PI 3-kinase p110 beta: a new target for antithrombotic therapy
SP Jackson, SM Schoenwaelder, I Goncalves, WS Nesbitt, CL Yap, CE Wright, V Kenche, KE Anderson, SM Dopheide, YP Yuan, SA Sturgeon, H Prabaharan, PE Thompson, GD Smith, PR Shepherd, N Daniele, S Kulkarni, B Abbott, D Saylik, C Jones, et al.
Journal article | 2005 | Nature Medicine
Structural factors increase blood pressure through the interaction of resistance vessel geometry with neurohumoral and local factors: estimates in rabbits with renal cellophane-wrap hypertension with intact effectors and during neurohumoral blockade
CE Wright, JA Angus, PI Korner
Journal article | 2002 | Journal of Hypertension
Erratum: Roles of key functional groups in ω-conotoxin GVIA. Synthesis, structure and functional assay of selected peptide analogues (European Journal of Biochemistry (1999) 262 (447-455))
JP Flinn, PK Pallaghy, MJ Lew, R Murphy, JA Angus, RS Norton
Journal article | 1999 | European Journal of Biochemistry
Structure-function relationships of omega-conotoxin GVIA - Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues
MJ Lew, JP Flinn, PK Pallaghy, R Murphy, SL Whorlow, CE Wright, RS Norton, JA Angus
Journal article | 1997 | Journal of Biological Chemistry
Synthesis and biological characterization of a series of analogues of omega-conotoxin GVIA.
JP Flinn, R Murphy, JH Boublik, MJ Lew, CE Wright, JA Angus
Journal article | 1995 | Journal of Peptide Science
The 27-residue polypeptide omega-conotoxin GVIA (omega-CgTx), from the venom of the cone shell Conus geographus, blocks N-type neu..
Are cardiac and vascular "amplifiers" both necessary for the development of hypertension?
PI Korner, A Bobik, JJ Angus
Conference Proceedings | 1992 | Kidney International, Supplement
The vascular amplifier leads to enhancement of all resistance responses, from full dilatation to maximum constriction. The mechani..
Amplifier function of resistance vessels and the left ventricle in hypertension.
PI Korner, JA Angus, A Bobik, GL Jennings
Conference Proceedings | 1991 | Journal of Hypertension
We have recently modeled the structural factors responsible for the increased slope of the dose-vascular resistance response curve..
Central sympathoinhibition and peripheral neuronal uptake blockade after desipramine in rabbits.
G Eisenhofer, T Saigusa, MD Esler, HS Cox, JA Angus, PK Dorward
Journal article | 1991 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Peripheral- and central nervous system (CNS)-mediated effects of desipramine (Des) on sympathetic nerves and the contribution of a..
Significance of cardiovascular hypertrophy in the development and maintenance of hypertension.
PI Korner, A Bobik, GL Jennings, JA Angus, WP Anderson
Conference Proceedings | 1991 | Journal of Cardiovascular Pharmacology
The amplifier properties associated with the structural changes in the heart and resistance vessels in chronic hypertension togeth..
SIMULTANEOUS DETERMINATION OF PLASMA NORADRENALINE AND ADRENALINE KINETICS - RESPONSES TO NITROPRUSSIDE-INDUCED HYPOTENSION AND 2-DEOXYGLUCOSE-INDUCED GLUCOPENIA IN THE RABBIT
OS MEDVEDEV, MD ESLER, JA ANGUS, HS COX, G EISENHOFER
Journal article | 1990 | Naunyn-Schmiedeberg's Archives of Pharmacology
Reactivity of human isolated internal mammary artery to constrictor and dilator agents. Implications for treatment of internal mammary artery spasm.
GW He, FL Rosenfeldt, BF Buxton, JA Angus
Journal article | 1989 | Circulation
Perioperative spasm of the internal mammary artery (IMA) may occur after coronary artery bypass surgery. To establish the most app..
Role of brain amine transmitters and some neuromodulators in blood pressure, heart rate, and baroreflex control.
PI Korner, GA Head, E Badoer, A Bobik, JA Angus
Journal article | 1987 | Journal of Cardiovascular Pharmacology
We studied the acute effects of transmitter release induced by intracisternal (i.c.) 6-hydroxydopamine (6-OHDA) from mainly noradr..
Role of auto-inhibitory feed-back in cardiac sympathetic transmission assessed by simultaneous measurements of changes in 3H-efflux and atrial rate in guinea-pig atrium.
JA Angus, A Bobik, GP Jackman, IJ Kopin, PI Korner
Journal article | 1984 | British Journal of Pharmacology
Guinea-pig right atria were labelled with [3H]-noradrenaline or [3H]-dopamine before superfusion in a flow-cell. Choice of label d..
Vasodilatation by acetylcholine is endothelium-dependent: a study by sonomicrometry in canine femoral artery in vivo.
JA Angus, GR Campbell, TM Cocks, JA Manderson
Journal article | 1983 | The Journal of Physiology
External diameter of the femoral artery was measured by sonomicrometry in the anaesthetized dog. Intra-arterial acetylcholine lowe..
Honours, Awards and Fellowships
Officer of the Order of Australia
FAHMS (Hon) - Fellow of the Australian Academy of Health and Medical Sciences Hon
Fellow, International Academy of Cardiovascular Sciences
FAA - Fellow of the Australian Academy of Science