Christine Wright is an Associate Professor in the Department of Pharmacology and Therapeutics where she is the head of the Cardiovascular Therapeutics Unit. She has established a strong reputation with 120 peer-reviewed publications; these have received 4296 citations to date (Google Scholar 11/2019).
Her current research interests and expertise include cardiovascular pharmacology in hypertension, regional vascular reactivity, endothelin and cannabidiol pharmacology. She has a long track record in analytical pharmacology of peptides such as endothelin and omega-conotoxins in sophisticated in vitro and in vivo bioassays, as well as in complex chronic cardiovascular disease models, especially hypertension, regional vascular reactivity and haemodynamics. The Cardiovascular Therapeutics Unit collaborates with Big Pharma and Australian Biotech companies in small to medium term contract research projects.
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Estimation of the vascular resistance amplifier in the renal vascular bed in conscious hyp..
The Investigation Of Endothelin Receptor Antagonists And Nitric Oxide Stimulators In The T..
The effects of varying Mg2 ion concentrations on contractions to the cotransmitters ATP an..
Williamson Foundation Phd Scholarship In Terrestrial Invertebrate Taxonomy At Museum Victo..
Displaying the 4 most recent projects by Christine Wright.
Displaying the 119 most recent scholarly works by Christine Wright.
The β2-adrenoceptor agonist bronchodilators terbutaline and orciprenaline are also weak α1-adrenoceptor antagonists.
Makhala M Khammy, Cindy Kha Han Truong, Christine E Wright, James A Angus
Journal article | 2020 | European Journal of Pharmacology
Recently, the β2-adrenoceptor agonist terbutaline was shown to have α1-adrenolytic activity in mouse isolated pulmonary arteries i..
The effects of varying Mg2 ion concentrations on contractions to the cotransmitters ATP and noradrenaline in the rat vas deferens
Amna C Mazeh, James A Angus, Christine E Wright
Journal article | 2019 | Autonomic Neuroscience
The vas deferens responds to a single electrical pulse with a biphasic contraction caused by cotransmitters ATP and noradrenaline...
Using high-resolution Twin-Ion Metabolite Extraction (HiTIME) mass spectrometry with stable isotope labelling to investigate the metabolism of valproic acid in vivo
Michael G Leeming, Noel Cranswick, Christine E Wright, James Ziogas, Terence J O'Brien, William A Donald, Richard AJ O'Hair
Journal article | 2019 | International Journal of Mass Spectrometry
Proteomics and antivenomics of Papuan black snake (Pseudechis papuanus) venom with analysis of its toxicological profile and the preclinical efficacy of Australian antivenoms
Davinia Pla, Benjamin W Bande, Ronelle E Welton, Owen K Paiva, Libia Sanz, Alvaro Segura, Christine E Wright, Juan J Calvete, Jose Maria Gutierrez, David J Williams
Journal article | 2017 | Journal of Proteomics
Neutralization of the neuromuscular inhibition of venom and taipoxin from the taipan (Oxyuranus scutellatus) by F(ab ') 2 and whole IgG antivenoms
Maria Herrera, Rita de Cassia de O Collaco, Mauren Villalta, Alvaro Segura, Mariangela Vargas, Christine E Wright, Owen K Paiva, Teatulohi Matainaho, Simon D Jensen, Guillermo Leon, David J Williams, Lea Rodrigues-Simioni, Jose Maria Gutierrez
Journal article | 2016 | Toxicology Letters
High-Resolution Twin-Ion Metabolite Extraction (HiTIME) Mass Spectrometry: Nontargeted Detection of Unknown Drug Metabolites by Isotope Labeling, Liquid Chromatography Mass Spectrometry, and Automated High-Performance Computing
Michael G Leeming, Andrew P Isaac, Bernard J Pope, Noel Cranswick, Christine E Wright, James Ziogas, Richard AJ O'Hair, William A Donald
Journal article | 2015 | ANALYTICAL CHEMISTRY
Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents
Bich Anh Chau, Grant Drummond, W Roy Jackson, Bevyn Jarrott, Alyson A Miller, Kamani R Subasinghe, Christina YR Tan, Paul J White, Christine E Wright, James Ziogas
Journal article | 2015 | MEDCHEMCOMM
Preclinical efficacy of Australian antivenoms against the venom of the small-eyed snake, Micropechis ikaheka, from Papua New Guinea: An antivenomics and neutralization study
Davinia Pla, Owen K Paiva, Libia Sanz, Markus Beutler, Christine E Wright, Juan J Calvete, David J Williams, Jose Maria Gutierrez
Journal article | 2014 | Journal of Proteomics
Membrane interactions and biological activity of antimicrobial peptides from Australian scorpion
Karen Luna-Ramirez, Marc-Antoine Sani, Jesus Silva-Sanchez, Juana Maria Jimenez-Vargas, Fernando Reyna-Flores, Kenneth D Winkel, Christine E Wright, Lourival D Possani, Frances Separovic
Journal article | 2014 | BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Structure, Molecular Modeling, and Function of the Novel Potassium Channel Blocker Urotoxin Isolated from the of the Australian Scorpion Urodacus yaschenkoi
Karen Luna-Ramirez, Adam Bartok, Rita Restano-Cassulini, Veronica Quintero-Hernandez, Fredy IV Coronas, Janni Christensen, Christine E Wright, Gyorgy Panyi, Lourival D Possani
Journal article | 2014 | Molecular Pharmacology
A review of local anesthetic cardiotoxicity and treatment with lipid emulsion.
Emma Bourne, Christine Wright, Colin Royse
Journal article | 2010 | Local and Regional Anesthesia
Cardiovascular collapse from accidental local anesthetic toxicity is a rare but catastrophic complication of regional anesthesia. ..
Synthesis and cannabinoid activity of 1-sub stituted-indole-3-oxadiazole derivatives: Novel agonists for the CB1 receptor
Gerard P Moloney, James A Angus, Alan D Robertson, Martin J Stoermer, Michael Robinson, Christine E Wright, Ken McRae, Arthur Christopoulos
Journal article | 2008 | European Journal of Medicinal Chemistry
Synthesis and cannabinoid activity of a variety of 2,3-substituted 1-benzo[b]thiophen derivatives and 2,3-substituted benzofuran: Novel agonists for the CB1 receptor
Gerard P Moloney, James A Angus, Alan D Robertson, Martin J Stoermer, Michael Robinson, Lucy Lay, Christine E Wright, Ken McRae, Arthur Christopoulos
Journal article | 2008 | Australian Journal of Chemistry
Adaptation of the Folts and electrolytic methods of arterial thrombosis for the study of anti-thrombotic molecules in small animals.
Sharelle A Sturgeon, Catherine Jones, James A Angus, Christine E Wright
Journal article | 2006 | Journal of Pharmacological and Toxicological Methods
INTRODUCTION: Animal preparations of arterial thrombosis play a crucial role in the discovery and validation of novel drug targets..
Cardiovascular actions of the venom from the Irukandji (Carukia barnesi) jellyfish: Effects in human, rat and guinea-pig tissues in vitro and in pigs in vivo
KD Winkel, J Tibballs, P Molenaar, G Lambert, P Coles, M Ross-Smith, C Wiltshire, PJ Fenner, LA Gershwin, GM Hawdon, CE Wright, JA Angus
Journal article | 2005 | Clinical and Experimental Pharmacology and Physiology
PI 3-kinase p110 beta: a new target for antithrombotic therapy
SP Jackson, SM Schoenwaelder, I Goncalves, WS Nesbitt, CL Yap, CE Wright, V Kenche, KE Anderson, SM Dopheide, YP Yuan, SA Sturgeon, H Prabaharan, PE Thompson, GD Smith, PR Shepherd, N Daniele, S Kulkarni, B Abbott, D Saylik, C Jones, et al.
Journal article | 2005 | Nature Medicine
Structural factors increase blood pressure through the interaction of resistance vessel geometry with neurohumoral and local factors: estimates in rabbits with renal cellophane-wrap hypertension with intact effectors and during neurohumoral blockade
CE Wright, JA Angus, PI Korner
Journal article | 2002 | Journal of Hypertension
Structure-function relationships of omega-conotoxin GVIA - Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues
MJ Lew, JP Flinn, PK Pallaghy, R Murphy, SL Whorlow, CE Wright, RS Norton, JA Angus
Journal article | 1997 | Journal of Biological Chemistry
Synthesis and biological characterization of a series of analogues of omega-conotoxin GVIA.
JP Flinn, R Murphy, JH Boublik, MJ Lew, CE Wright, JA Angus
Journal article | 1995 | Journal of Peptide Science
The 27-residue polypeptide omega-conotoxin GVIA (omega-CgTx), from the venom of the cone shell Conus geographus, blocks N-type neu..
omega-Conotoxin GVIA and prazosin, but not felodipine, cause postural hypotension in rabbits.
AL Hawkes, JA Angus, CE Wright
Journal article | 1995 | Clin Exp Pharmacol Physiol
1. The aim was to compare the effect of N-type calcium channel blockade by omega-conotoxin GVIA (omega-CTX) with alpha 1-adrenocep..
5-carboxamidotryptamine elicits 5-HT2 and 5-HT3 receptor-mediated cardiovascular responses in the conscious rabbit: evidence for 5-HT release from platelets.
CE Wright, JA Angus
Journal article | 1989 | J Cardiovasc Pharmacol
The selective "5-HT1-like" receptor agonist 5-carboxamidotryptamine (5-CT, 0.2-1.6 micrograms/kg bolus i.v.), serotonin (5-HT, 3-1..