Christine Wright

Pharmacological characterisation of the CB1 receptor antagonist activity of cannabidiol in the rat vas deferens bioassay.

Amna C Mazeh, James A Angus, Christine E Wright

Journal article  |  2021  |  Eur J Pharmacol

Cannabidiol is increasingly considered for treatment of a wide range of medical conditions. Binding studies suggest that cannabidi..

Zinc drives vasorelaxation by acting in sensory nerves, endothelium and smooth muscle

Ashenafi H Betrie, James A Brock, Osama F Harraz, Ashley Bush, Guo-Wei He, Mark T Nelson, James A Angus, Christine E Wright, Scott Ayton

Journal article  |  2021  |  NATURE COMMUNICATIONS

Zinc, an abundant transition metal, serves as a signalling molecule in several biological systems. Zinc transporters are genetical..

Cannabidiol selectively inhibits the contraction of rat small resistance arteries: Possible role for CGRP and voltage-gated calcium channels

Amna C Mazeh, James A Angus, Christine E Wright

Journal article  |  2021  |  EUROPEAN JOURNAL OF PHARMACOLOGY

The pharmacology of cannabidiol, the non-psychoactive major component of Cannabis sativa, is of growing interest as it becomes mor..

The beta(2)-adrenoceptor agonist bronchodilators terbutaline and orciprenaline are also weak alpha(1)-adrenoceptor antagonists

Makhala M Khammy, Cindy Kha Han Truong, Christine E Wright, James A Angus

Journal article  |  2020  |  EUROPEAN JOURNAL OF PHARMACOLOGY

Recently, the β2-adrenoceptor agonist terbutaline was shown to have α1-adrenolytic activity in mouse isolated pulmonary arteries i..

Estimation of the vascular resistance amplifier in the renal vascular bed in conscious hypertensive rabbits: comparison with the total peripheral vasculature

Makhala M Khammy, James A Angus, Christine E Wright

Journal article  |  2020  |  HELIYON

Objectives: The vascular amplifier in hypertension is a result of structural changes in resistance arteries. We estimated the vasc..

The effects of varying Mg2 ion concentrations on contractions to the cotransmitters ATP and noradrenaline in the rat vas deferens

Amna C Mazeh, James A Angus, Christine E Wright

Journal article  |  2019  |  AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

The vas deferens responds to a single electrical pulse with a biphasic contraction caused by cotransmitters ATP and noradrenaline...

Using high-resolution Twin-Ion Metabolite Extraction (HiTIME) mass spectrometry with stable isotope labelling to investigate the metabolism of valproic acid in vivo

Michael G Leeming, Noel Cranswick, Christine E Wright, James Ziogas, Terence J O'Brien, William A Donald, Richard AJ O'Hair

Journal article  |  2019  |  INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Valproic acid (VPA) is a medication that is widely used in the treatment of epilepsy and bipolar disorder, despite a known potenti..

Role of endothelin-1 clearance in the haemodynamic responses to endothelin-1 in the pulmonary and hindquarter vasculature of anaesthetised rats

James A Angus, Christine E Wright

Journal article  |  2019  |  EUROPEAN JOURNAL OF PHARMACOLOGY

In the pulmonary vasculature there is clearance of endothelin-1 from the circulation mediated by endothelin ETB receptors. This st..

Letter by Angus and Wright Regarding Article, "Pannexin-1 Channels as an Unexpected New Target of the Antihypertensive Drug Spironolactone"

James A Angus, Christine E Wright

Journal article  |  2018  |  CIRCULATION RESEARCH

Distortion of K-B estimates of endothelin-1 ETA and ETB receptor antagonists in pulmonary arteries: Possible role of an endothelin-1 clearance mechanism

James A Angus, Richard JA Hughes, Christine E Wright

Journal article  |  2017  |  PHARMACOLOGY RESEARCH & PERSPECTIVES

Dual endothelin ETA and ETB receptor antagonists are approved therapy for pulmonary artery hypertension (PAH). We hypothesized tha..