Alice Pebay

Automated system for maintenance and differentiation of pluripotent stem cells

Alice Pebay, alex HEWITT, Duncan Crombie, RAY Wong, helena Liang, Maciej Daniszewski

(WO/2007/012144) COMPOSITIONS AND METHODS FOR GROWTH OF PLURIPOTENT CELLS

A PEBAY, A Michalska, M Pera

Methods of regulating differentiation of stem cells

A PEBAY, M Pera

Culture Variabilities of Human iPSC-Derived Cerebral Organoids Are a Major Issue for the Modelling of Phenotypes Observed in Alzheimer's Disease.

Damián Hernández, Louise A Rooney, Maciej Daniszewski, Lerna Gulluyan, Helena H Liang, Anthony L Cook, Alex W Hewitt, Alice Pébay

Journal article  |  2021  |  Stem Cell Reviews and Reports

Apolipoprotein E (APOE) is the most important susceptibility gene for late onset of Alzheimer's disease (AD), with the presence of..

Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells.

Drew Neavin, Quan Nguyen, Maciej S Daniszewski, Helena H Liang, Han Sheng Chiu, Yong Kiat Wee, Anne Senabouth, Samuel W Lukowski, Duncan E Crombie, Grace E Lidgerwood, Damián Hernández, James C Vickers, Anthony L Cook, Nathan J Palpant, Alice Pébay, Alex W Hewitt, Joseph E Powell

Journal article  |  2021  |  Genome Biology

BACKGROUND: The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) has provided a foundati..

Use of CRISPR/Cas ribonucleoproteins for high throughput gene editing of induced pluripotent stem cells.

Qi Wang, Sueanne Chear, Kristof Wing, David Stellon, Minh Thuan Nguyen Tran, Jana Talbot, Alice Pébay, Alex W Hewitt, Anthony L Cook

Journal article  |  2021  |  Methods

Induced pluripotent stem cells (iPSCs) have become widely used for disease modelling, particularly with regard to predisposing gen..

The Use of Human Pluripotent Stem Cells (hPSCs) and CRISPR-Mediated Gene Editing in Retinal Diseases

Grace E Lidgerwood, Alex W Hewitt, Alice Pébay, Damián Hernández

Book Chapter  |  2021

Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.

Grace E Lidgerwood, Anne Senabouth, Casey JA Smith-Anttila, Vikkitharan Gnanasambandapillai, Dominik C Kaczorowski, Daniela Amann-Zalcenstein, Erica L Fletcher, Shalin H Naik, Alex W Hewitt, Joseph E Powell, Alice Pébay

Journal article  |  2020  |  Genomics Proteomics & Bioinformatics

Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells, presenting a potential limitation to the accu..

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

Lezanne Ooi, Mirella Dottori, Anthony L Cook, Martin Engel, Vini Gautam, Alexandra Grubman, Damian Hernandez, Anna E King, Simon Maksour, Helena Targa Dias Anastacio, Rachelle Balez, Alice Pebay, Colin Pouton, Michael Valenzuela, Anthony White, Robert Williamson

Journal article  |  2020  |  The Neuroscientist: reviews at the interface of basic and clinical neurosciences

Because our beliefs regarding our individuality, autonomy, and personhood are intimately bound up with our brains, there is a publ..

Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing

Minh Thuan Nguyen Tran, Mohd Khairul Nizam Mohd Khalid, Qi Wang, Jacqueline KR Walker, Grace E Lidgerwood, Kimberley L Dilworth, Leszek Lisowski, Alice Pebay, Alex W Hewitt

Journal article  |  2020  |  Nature Communications

Precision genome engineering has dramatically advanced with the development of CRISPR/Cas base editing systems that include cytosi..

Comparison of CRISPR/Cas Endonucleases forin vivoRetinal Gene Editing

Fan Li, Kristof Wing, Jiang-Hui Wang, Chi D Luu, James A Bender, Jinying Chen, Qi Wang, Qinyi Lu, Minh Thuan Nguyen Tran, Kaylene M Young, Raymond CB Wong, Alice Pebay, Anthony L Cook, Sandy SC Hung, Guei-Sheung Liu, Alex W Hewitt

Journal article  |  2020  |  Frontiers in Cellular Neuroscience

A Simple Differentiation Protocol for Generation of Induced Pluripotent Stem Cell-Derived Basal Forebrain-Like Cholinergic Neurons for Alzheimer's Disease and Frontotemporal Dementia Disease Modeling

Sonia Sanz Munoz, Martin Engel, Rachelle Balez, Dzung Do-Ha, Mauricio Castro Cabral-da-Silva, Damian Hernandez, Tracey Berg, Jennifer A Fifita, Natalie Grima, Shu Yang, Ian P Blair, Garth Nicholson, Anthony L Cook, Alex W Hewitt, Alice Pebay, Lezanne Ooi

Journal article  |  2020  |  Cells

The study of neurodegenerative diseases using pluripotent stem cells requires new methods to assess neurodevelopment and neurodege..

Comparative performance of the BGI and Illumina sequencing technology for single-cell RNA-sequencing.

Anne Senabouth, Stacey Andersen, Qianyu Shi, Lei Shi, Feng Jiang, Wenwei Zhang, Kristof Wing, Maciej Daniszewski, Samuel W Lukowski, Sandy SC Hung, Quan Nguyen, Lynn Fink, Anthony Beckhouse, Alice Pébay, Alex W Hewitt, Joseph E Powell

Journal article  |  2020  |  NAR Genom Bioinform

The libraries generated by high-throughput single cell RNA-sequencing (scRNA-seq) platforms such as the Chromium from 10× Genomics..