Alice Pebay

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

Lezanne Ooi, Mirella Dottori, Anthony L Cook, Martin Engel, Vini Gautam, Alexandra Grubman, Damian Hernandez, Anna E King, Simon Maksour, Helena Targa Dias Anastacio, Rachelle Balez, Alice Pebay, Colin Pouton, Michael Valenzuela, Anthony White, Robert Williamson

Journal article  |  2020  |  The Neuroscientist

Because our beliefs regarding our individuality, autonomy, and personhood are intimately bound up with our brains, there is a publ..

Genotype-free demultiplexing of pooled single-cell RNA-seq.

Jun Xu, Caitlin Falconer, Quan Nguyen, Joanna Crawford, Brett D McKinnon, Sally Mortlock, Anne Senabouth, Stacey Andersen, Han Sheng Chiu, Longda Jiang, Nathan J Palpant, Jian Yang, Michael D Mueller, Alex W Hewitt, Alice Pébay, Grant W Montgomery, Joseph E Powell, Lachlan JM Coin

Journal article  |  2019  |  Genome Biology

A variety of methods have been developed to demultiplex pooled samples in a single cell RNA sequencing (scRNA-seq) experiment whic..

Differentiation of Retinal Glial Cells From Human Embryonic Stem Cells by Promoting the Notch Signaling Pathway

Sook Hyun Chung, Weiyong Shen, Kathryn C Davidson, Alice Pebay, Raymond CB Wong, Belinda Yau, Mark Gillies

Journal article  |  2019  |  Frontiers in Cellular Neuroscience

Optimization of silk fibroin membranes for retinal implantation

Shuko Suzuki, Audra MA Shadforth, Samuel McLenachan, Dan Zhang, Shang-Chih Chen, Jennifer Walshe, Grace E Lidgerwood, Alice Pebay, Traian Chirila, Fred K Chen, Damien G Harkin

Journal article  |  2019  |  Materials Science and Engineering: C

Utility of Self-Destructing CRISPR/Cas Constructs for Targeted Gene Editing in the Retina

Fan Li, Sandy SC Hung, Mohd Khairul Nizam Mohd Khalid, Jiang-Hui Wang, Vicki Chrysostomou, Vickie HY Wong, Vikrant Singh, Kristof Wing, Leilei Tu, James A Bender, Alice Pebay, Anna E King, Anthony L Cook, Raymond CB Wong, Bang Bui, Alex W Hewitt, Guei-Sheung Liu

Journal article  |  2019  |  Human Gene Therapy

PSEN1 Delta E9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Henna Konttinen, Mauricio E Castro Cabral-da-Silva, Sohvi Ohtonen, Sara Wojciechowski, Anastasia Shakirzyanova, Simone Caligola, Rosalba Giugno, Yevheniia Ishchenko, Damian Hernandez, Mohammad Feroze Fazaludeen, Shaila Eamen, Mireia Gomez Budia, Ilkka Fagerlund, Flavia Scoyni, Paula Korhonen, Nadine Huber, Annakaisa Haapasalo, Alex W Hewitt, James Vickers, Grady C Smith, et al.

Journal article  |  2019  |  Stem Cell Reports

Human pluripotent stem cells for the modelling of diseases of the retina and optic nerve: toward a retina in a dish

Grace E Lidgerwood, Alex W Hewitt, Alice Pebay

Journal article  |  2019  |  Current Opinion in Pharmacology

Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retin..

Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells

Jarmon G Lees, Anne M Kong, Yi C Chen, Priyadharshini Sivakumaran, Damian Hernandez, Alice Pebay, Alexandra J Harvey, David K Gardner, Shiang Y Lim

Journal article  |  2019  |  Stem Cells International

Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease

Xavier Hadoux, Flora Hui, Jeremiah KH Lim, Colin L Masters, Alice Pebay, Sophie Chevalier, Jason Ha, Samantha Loi, Christopher J Fowler, Christopher Rowe, Victor L Villemagne, Edward N Taylor, Christopher Fluke, Jean-Paul Soucy, Frederic Lesage, Jean-Philippe Sylvestre, Pedro Rosa-Neto, Sulantha Mathotaarachchi, Serge Gauthier, Ziad S Nasreddine, et al.

Journal article  |  2019  |  Nature Communications

Bio-engineering a tissue flap utilizing a porous scaffold incorporating a human induced pluripotent stem cell-derived endothelial cell capillary network connected to a vascular pedicle

Anne M Kong, Kiryu K Yap, Shiang Y Lim, Diego Marre, Alice Pebay, Yi-wen Gerrand, Jarmon G Lees, Jason A Palmer, Wayne A Morrison, Geraldine M Mitchell

Journal article  |  2019  |  Acta Biomaterialia

Tissue flaps are used to cover large/poorly healing wounds, but involve complex surgery and donor site morbidity. In this study a ..

CRISPR/Cas-mediated base editing of the AMD high-risk Y402H complement factor H variant

Alex W Hewitt, Peter Tran, Mohd Khairul Nizam Mohd Khalid, Alice Pebay, Anthony L Cook, Helena Liang, Raymond Wong, Jamie E Craig, Guei-Sheung Liu, Sandy Hung

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Screening of CRISPR/Cas base editors to target the AMD high-risk Y402H complement factor H variant

Thuan Nguyen Tran Minh, Mohd Khairul Nizam Mohd Khalid, Alice Pebay, Anthony L Cook, Helena H Liang, Raymond CB Wong, Jamie E Craig, Guei-Sheung Liu, Sandy S Hung, Alex W Hewitt

Journal article  |  2019  |  Molecular Vision

A Need for Better Understanding Is the Major Determinant for Public Perceptions of Human Gene Editing

Tristan McCaughey, David M Budden, Paul G Sanfilippo, George EC Gooden, Li Fan, Eva Fenwick, Gwyneth Rees, Casimir MacGregor, Lei Si, Christine Chen, Helena Hai Liang, Alice Pebay, Timothy Baldwin, Alex W Hewitt

Journal article  |  2019  |  Human Gene Therapy

The CRISPR/Cas system could provide an efficient and reliable means of editing the human genome and has the potential to revolutio..

An overview of human pluripotent stem cell applications for the understanding and treatment of blindness

Alice Pebay, Grace Lidgerwood, Louise Rooney, Duncan Crombie, Maciej Daniszewski

Book Chapter  |  2019

Human pluripotent stem cells (hPSCs) hold great promise for human therapies including for treatment of eye-related disease. Given ..

The current state of stem cell therapy for ocular disease

Samantha Bobba, Nick Di Girolamo, Megan Munsie, Fred Chen, Alice Pebay, Damien Harkin, Alex W Hewitt, Michael O'Connor, Samuel McLenachan, Audra MA Shadforth, Stephanie L Watson

Journal article  |  2018  |  Experimental Eye Research

A RANZCO POSITION STATEMENT ON OCULAR STEM CELL THERAPY

Samantha Bobba, Nick Di Girolamo, Megan Munsie, Fred Chen, Alice Pebay, Damien Harkin, Alex Hewitt, Michael O'Connor, Samuel McLenachan, Audra Shadforth, Stephanie Watson

Conference Proceedings  |  2018  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology

Grace E Lidgerwood, Stuart M Pitson, Claudine Bonder, Alice Pebay

Journal article  |  2018  |  Progress in Lipid Research

Single-Cell Profiling Identifies Key Pathways Expressed by iPSCs Cultured in Different Commercial Media

Maciej Daniszewski, Nguyen Quan, Hun S Chy, Vikrant Singh, Duncan E Crombie, Tejal Kulkarni, Helena H Liang, Priyadharshini Sivakumaran, Grace E Lidgerwood, Damien Hernandez, Alison Conquest, Louise A Rooney, Sophie Chevalier, Stacey B Andersen, Anne Senabouth, James C Vickers, David A Mackey, Jamie E Craig, Andrew L Laslett, Alex W Hewitt, et al.

Journal article  |  2018  |  iScience

Automated Cell Culture Systems and Their Applications to Human Pluripotent Stem Cell Studies

Maciej Daniszewski, Duncan E Crombie, Rachael Henderson, Helena H Liang, Raymond CB Wong, Alex W Hewitt, Alice Pebay

Journal article  |  2018  |  SLAS TECHNOLOGY: Translating Life Sciences Innovation

Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network

Celeste M Karch, Damian Hernandez, Jen-Chyong Wang, Jacob Marsh, Alex W Hewitt, Simon Hsu, Joanne Norton, Denise Levitch, Tamara Donahue, Wendy Sigurdson, Bernardino Ghetti, Martin Farlow, Jasmeer Chhatwal, Sarah Berman, Carlos Cruchaga, John C Morris, Randall J Bateman, Alice Pebay, Alison M Goate

Journal article  |  2018  |  Alzheimer's Research & Therapy

Longitudinal expression profiling of CD4 and CD8 cells in patients with active to quiescent giant cell arteritis

Elisabeth De Smit, Samuel W Lukowski, Lisa Anderson, Anne Senabouth, Kaisar Dauyey, Sharon Song, Bruce Wyse, Lawrie Wheeler, Christine Y Chen, Khoa Cao, Amy Wong Ten Yuen, Neil Shuey, Linda Clarke, Isabel Lopez Sanchez, Sandy SC Hung, Alice Pebay, David A Mackey, Matthew A Brown, Alex W Hewitt, Joseph E Powell

Journal article  |  2018  |  BMC Medical Genomics

Transcriptome sequencing and molecular markers discovery in the gonads of Portunus sanguinolentus.

Yin Zhang, Guidong Miao, Qingyang Wu, Fan Lin, Cuihong You, Shuqi Wang, Jude Juventus Aweya, Hongyu Ma

Journal article  |  2018  |  Scientific Data

Crab culture has gained prominence in the last decade due to the large global market demand for live crabs and crab products. Port..

Role of lysophosphatidic acid in the retinal pigment epithelium and photoreceptors

Grace E Lidgerwood, Andrew J Morris, Alison Conquest, Maciej Daniszewski, Louise A Rooney, Shiang Y Lim, Damian Hernandez, Helena H Liang, Penelope Allen, Paul P Connell, Robyn H Guymer, Alex W Hewitt, Alice Pebay

Journal article  |  2018  |  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Refining retinal ganglion cell (RGC) differentiation from human pluripotent stem cells (hPSCs)

Maciej Daniszewski, Duncan Crombie, Louise Rooney, Alison Conquest, Alex W Hewitt, Alice Pebay

Conference Proceedings  |  2018  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells

Ashfaqul Hogue, Priyadharshini Sivakumaran, Simon T Bond, Naomi XY Ling, Anne M Kong, John W Scott, Nadeeka Bandara, Damian Hernandez, Guei-Sheung Liu, Raymond CB Wong, Michael T Ryan, Derek J Hausenloy, Bruce E Kemp, Jonathan S Oakhill, Brian G Drew, Alice Pebay, Shiang Y Lim

Journal article  |  2018  |  Cell Death Discovery

Single cell RNA sequencing of stem cell-derived retinal ganglion cells

Maciej Brisbane Daniszewski, Anne Senabouth, Quan H Nguyen, Duncan E Crombie, Samuel W Lukowski, Tejal Kulkarni, Valentin M Sluch, Jafar S Jabbari, Xitiz Chamling, Donald J Zack, Alice Pebay, Joseph E Powell, Alex W Hewitt

Journal article  |  2018  |  Scientific Data

Biologically active constituents of the secretome of human W8B2( ) cardiac stem cells

Shuai Nie, Xin Wang, Priyadharshini Sivakumaran, Mark MW Chong, Xin Liu, Tara Karnezis, Nadeeka Bandara, Kaloyan Takov, Cameron J Nowell, Stephen Wilcox, Mitch Shambrook, Andrew F Hill, Nicole C Harris, Andrew E Newcomb, Padraig Strappe, Ramin Shayan, Damian Hernandez, Jordan Clarke, Eric Hanssen, Sean M Davidson, et al.

Journal article  |  2018  |  Scientific Reports

Maintenance of Human Embryonic Stem Cells by Sphingosine-1-Phosphate and Platelet-Derived Growth Factor.

Raymond CB Wong, Martin F Pera, Alice Pébay

Book Chapter  |  2018  |  Methods in Molecular Biology

Human embryonic stem cells (hESCs) have historically been cultivated on feeder layers of primary mouse embryonic fibroblasts (MEF)..

Influence of continuous electrical stimulation on development of human cardiomyocytes from induced pluripotent stem cells

Damián Hernández, Rodney Millard, Priyadharshini Sivakumaran, A Kong, G Mitchell, Alice Pebay, R Sheperd, Gregory Dusting, S Lim

Journal article  |  2018  |  Conditioning Medicine

Regeneration of cardiac tissue remains an ideal approach to restore cardiac function after myocardial infarction. The ability of h..

Biologically active composition of human W8B2( ) cardiac stem cell secretome

P Sivakumaran, S Nie, X Wang, T Karnezis, N Bandara, C Nowell, S Wilcox, AF Hill, M Shambrook, NC Harris, AE Newcomb, P Strappe, R Shayan, D Hernandez, J Clarke, GJ Dusting, K Takov, S Davidson, E Hanssen, A Pebay, et al.

Conference Proceedings  |  2017  |  HUMAN GENE THERAPY

Drusen in patient-derived hiPSC-RPE models of macular dystrophies

Chad A Galloway, Sonal Dalvi, Sandy SC Hung, Leslie A MacDonald, Lisa R Latchney, Raymond CB Wong, Robyn H Guymer, David A Mackey, David S Williams, Mina M Chung, David M Gamm, Alice Pebay, Alex W Hewitt, Ruchira Singh

Journal article  |  2017  |  Proceedings of the National Academy of Sciences

Single Cell RNA Sequencing of stem cell-derived retinal ganglion cells

Maciej Daniszewski, Anne Senabouth, Quan Nguyen, Duncan Crombie, Samuel Lukowski, Tejal Kulkarni, Donald Zack, Alice Pébay, Joseph Powell, Alex Hewitt

Journal article  |  2017

ABSTRACT We used human embryonic stem cell-derived retinal ganglion cells (RGCs) to characterize the transcriptome of 1,174 cells ..

Development of a Modular Automated System for Maintenance and Differentiation of Adherent Human Pluripotent Stem Cells

Duncan E Crombie, Maciej Daniszewski, Helena H Liang, Tejal Kulkarni, Fan Li, Grace E Lidgerwood, Alison Conquest, Damian Hernandez, Sandy S Hung, Katherine P Gill, Elisabeth De Smit, Lisa S Kearns, Linda Clarke, Valentin M Sluch, Xitiz Chamling, Donald J Zack, Raymond CB Wong, Alex W Hewitt, Alice Pebay

Journal article  |  2017  |  SLAS DISCOVERY: Advancing the Science of Drug Discovery

The immortal life of ethics? The alienation of body tissue, ethics and the informed consent procedure within induced pluripotent stem cell research

C MacGregor, T McCaughey, M Munsie, A Pébay, A Hewitt

Book Chapter  |  2017

The role of lysophosphatidic acid (LPA) and in the maintenance of the blood retina barrier and photoreceptor function

G Lidgerwood, A Morris, J Prier, S Lim, H Peshavariya, E De Smit, L Clarke, A Conquest, D Hernandez, P McKelvie, R Sabbadini, L Mackay, A Hewitt, A Pebay

Conference Proceedings  |  2017  |  JOURNAL OF NEUROCHEMISTRY

Generation of a human induced pluripotent stem cell line CERAi001-A-6 using episomal vectors

Raymond CB Wong, Sandy S Hung, Stacey Jackson, Vikrant Singh, Shahnaz Khan, Helena H Liang, Lisa S Kearns, Tu Nguyena, Alison Conquest, Maciej Daniszewski, Alex W Hewitt, Alice Pebay

Journal article  |  2017  |  Stem Cell Research

RPE autonomous molecular events are sufficient for drusen biogenesis and extracellular matrix alterations in hiPSC-derived models of macular degeneration.

Ruchira Singh, Sonal Dalvi, Leslie MacDonald, Sandy Hung, Alex W Hewitt, Alice Pebay, David S Williams, Chad Alan Galloway

Conference Proceedings  |  2017  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

CONSTRUCTING HUMAN CARDIAC TISSUE FROM PLURIPOTENT STEM CELLS INCLUDING ELECTRICAL STIMULATION

GJ Dusting, D Hernandez, P Sivakumaran, RK Shepherd, Wong CB Raymond, A Pebay, SY Lim

Conference Proceedings  |  2017  |  HYPERTENSION

Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency

Duncan E Crombie, Claire L Curl, Antonia JA Raaijmakers, Priyadharshini Sivakumaran, Tejal Kulkarni, Raymond CB Wong, Itsunari Minami, Marguerite V Evans-Galea, Shiang Y Lim, Lea Delbridge, Louise A Corben, Mirella Dottori, Norio Nakatsuji, Ian A Trounce, Alex W Hewitt, Martin B Delatycki, Martin F Pera, Alice Pebay

Journal article  |  2017  |  Aging

Mitochondrial replacement in an iPSC model of Leber's hereditary optic neuropathy

Raymond CB Wong, Shiang Y Lim, Sandy SC Hung, Stacey Jackson, Shahnaz Khan, Nicole J Van Bergen, Elisabeth De Smit, Helena H Liang, Lisa S Kearns, Linda Clarke, David A Mackey, Alex W Hewitt, Ian A Trounce, Alice Pebay

Journal article  |  2017  |  Aging

Automated system for maintenance and differentiation of pluripotent stem cells

Alice Pebay, alex HEWITT, Duncan Crombie, RAY Wong, helena Liang, Maciej Daniszewski

Patent  |  2017

Role of ectonucleotide pyrophosphatase/phosphodiesterase 2 in the midline axis formation of zebrafish

Frisca Frisca, Daniel Colquhoun, Yona Goldshmit, Minna-Liisa Anko, Alice Pebay, Jan Kaslin

Journal article  |  2016  |  Scientific Reports

Peeking into the molecular trove of discarded surgical specimens

Alex W Hewitt, Anthony L Cook, Alice Pebay

Journal article  |  2016  |  Clinical & Experimental Ophthalmology

LONGITUDINAL EXPRESSION PROFILING OF T LYMPHOCYTES IN PATIENTS WITH ACTIVE TO QUIESCENT GIANT CELL ARTERITIS

Elisabeth De Smit, Linda Clarke, Khoa Ngygen, Neil Shuey, Catherine Hill, Lisa Anderson, David Evans, Matt A Brown, Joseph Powell, Alex W Hewitt

Conference Proceedings  |  2016  |  BMC Medical Genomics

Participant understanding and recall of informed consent for induced pluripotent stem cell biobanking

Tristan McCaughey, Christine Y Chen, Elisabeth De Smit, Gwyneth Rees, Eva Fenwick, Lisa S Kearns, David A Mackey, Casimir MacGregor, Megan Munsie, Anthony L Cook, Alice Pebay, Alex W Hewitt

Journal article  |  2016  |  Cell and Tissue Banking

Assessment of pluripotent stem cell clonality and virtual karyotype, of cells from patients with eye disease, using low-density SNP arrays

Alex W Hewitt, Duncan E Crombie, Kathryn Davidson, Helena Liang, Ray Wong, Sandy Shen-Chi Hung, Sook Chung, Alice Pebay

Conference Proceedings  |  2016  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

ALPK3-deficient cardiomyocytes generated from patient-derived induced pluripotent stem cells and mutant human embryonic stem cells display abnormal calcium handling and establish that ALPK3 deficiency underlies familial cardiomyopathy(aEuro)

Dean G Phelan, David J Anderson, Sara E Howden, Raymond CB Wong, Peter F Hickey, Kate Pope, Gabrielle R Wilson, Alice Pebay, Andrew M Davis, Steven Petrou, Andrew G Elefanty, Edouard G Stanley, Paul A James, Ivan Macciocca, Melanie Bahlo, Michael M Cheung, David J Amor, David A Elliott, Paul J Lockhart

Journal article  |  2016  |  European Heart Journal

Enriched retinal ganglion cells derived from human embryonic stem cells

Katherine P Gill, Sandy SC Hung, Alexei Sharov, Camden Y Lo, Karina Needham, Grace E Lidgerwood, Stacey Jackson, Duncan E Crombie, Bryony A Nayagam, Anthony L Cook, Alex W Hewitt, Alice Pebay, Raymond CB Wong

Journal article  |  2016  |  Scientific Reports

Genome engineering in ophthalmology: Application of CRISPR/Cas to the treatment of eye disease

Sandy SC Hung, Tristan McCaughey, Olivia Swann, Alice Pebay, Alex W Hewitt

Journal article  |  2016  |  Progress in Retinal and Eye Research

Targeted therapeutic mild hypercapnia after cardiac arrest: A phase II multi-centre randomised controlled trial (the CCC trial)

Glenn M Eastwood, Antoine G Schneider, Satoshi Suzuki, Leah Peck, Helen Young, Aiko Tanaka, Johan Martensson, Stephen Warrillow, Shay McGuinness, Rachael Parke, Eileen Gilder, Lianne Mccarthy, Pauline Galt, Gopal Taori, Suzanne Eliott, Tammy Lamac, Michael Bailey, Nerina Harley, Deborah Barge, Carol L Hodgson, et al.

Journal article  |  2016  |  Resuscitation

Inhibiting mitochondrial fission with Mdivi-1 directs cardiac differentiation of human induced pluripotent stem cells via protein kinase CK2

S Lim, P Sivakumaran, D Hernandez, RCB Wong, C Taylor, G Dusting, A Pebay

Conference Proceedings  |  2016  |  Cardiovascular Research

Benefits of electrical stimulation on differentiation and maturation of cardiomyocytes from human induced pluripotent stem cells

GJ Dusting, D Hernandez, P Sivakumaran, R Millard, RCB Wong, A Pebay, RK Shepherd, SY Lim

Conference Proceedings  |  2016  |  CARDIOVASCULAR RESEARCH

Using human pluripotent stem cells to study Friedreich ataxia cardiomyopathy

Duncan E Crombie, Martin F Pera, Martin B Delatycki, Alice Pebay

Journal article  |  2016  |  International Journal of Cardiology

AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo

Sandy SC Hung, Vicki Chrysostomou, Fan Li, Jeremiah KH Lim, Jiang-Hui Wang, Joseph E Powell, Leilei Tu, Maciej Daniszewski, Camden Lo, Raymond C Wong, Jonathan G Crowston, Alice Pebay, Anna E King, Bang V Bui, Guei-Sheung Liu, Alex W Hewitt

Journal article  |  2016  |  Investigative Opthalmology & Visual Science

A Global Social Media Survey of Attitudes to Human Genome Editing

Tristan McCaughey, Paul G Sanfilippo, George EC Gooden, David M Budden, Li Fan, Eva Fenwick, Gwyneth Rees, Casimir MacGregor, Lei Si, Christine Chen, Helena Hai Liang, Timothy Baldwin, Alice Pebay, Alex W Hewitt

Journal article  |  2016  |  Cell Stem Cell

CARDIAC REPAIR BY DIFFERENTIATION AND MATURATION OF CARDIOMYOCYTES FROM HUMAN INDUCED PLURIPOTENT STEM CELLS: THE BENEFITS OF SHORT- AND LONG-TERM ELECTRICAL STIMULATION

D Hernandez, P Sivakumaran, R Millard, RCB Wong, AW Hewitt, H Liang, SSC Hung, A Pebay, RK Shepherd, SY Lim, GJ Dusting

Conference Proceedings  |  2016  |  HYPERTENSION

Study of mitochondrial respiratory defects on reprogramming to human induced pluripotent stem cells

Sandy SC Hung, Nicole J Van Bergen, Stacey Jackson, Helena Liang, David A Mackey, Damian Hernandez, Shiang Y Lim, Alex W Hewitt, Ian Trounce, Alice Pebay, Raymond CB Wong

Journal article  |  2016  |  Aging

Defined Medium Conditions for the Induction and Expansion of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium

Grace E Lidgerwood, Shiang Y Lim, Duncan E Crombie, Ray Ali, Katherine P Gill, Damian Hernandez, Josh Kie, Alison Conquest, Hayley S Waugh, Raymond CB Wong, Helena H Liang, Alex W Hewitt, Kathryn C Davidson, Alice Pebay

Journal article  |  2016  |  Stem Cell Reviews and Reports

An Interactive Multimedia Approach to Improving Informed Consent for Induced Pluripotent Stem Cell Research

Tristan McCaughey, Helena H Liang, Christine Chen, Eva Fenwick, Gwyneth Rees, Raymond CB Wong, James C Vickers, Mathew J Summers, Casimir MacGregor, Jamie E Craig, Megan Munsie, Alice Pebay, Alex W Hewitt

Journal article  |  2016  |  Cell Stem Cell

Study of Gap Junctions in Human Embryonic Stem Cells.

Alice Pébay, Raymond CB Wong

Book Chapter  |  2016  |  Methods in Molecular Biology

Gap junctional intercellular communication (GJIC) has been described in different cell types including stem cells and has been inv..

Enhancing Human Cardiomyocyte Differentiation from Induced Pluripotent Stem Cells with Trichostatin A.

Shiang Y Lim, Priyadharshini Sivakumaran, Duncan E Crombie, Gregory J Dusting, Alice Pébay, Rodney J Dilley

Journal article  |  2016  |  Methods in molecular biology (Clifton, N.J.)

Human induced pluripotent stem (iPS) cells are a promising source of autologous cardiomyocytes to repair and regenerate myocardium..

Electrical Stimulation Promotes Cardiac Differentiation of Human Induced Pluripotent Stem Cells

Damian Hernandez, Rodney Millard, Priyadharshini Sivakumaran, Raymond CB Wong, Duncan E Crombie, Alex W Hewitt, Helena Liang, Sandy SC Hung, Alice Pebay, Robert K Shepherd, Gregory J Dusting, Shiang Y Lim

Journal article  |  2016  |  Stem Cells International

Characterization of the retinal pigment epithelium in Friedreich ataxia.

Duncan E Crombie, Nicole Van Bergen, Kathryn C Davidson, Sara Anjomani Virmouni, Penny A Mckelvie, Vicki Chrysostomou, Alison Conquest, Louise A Corben, Mark A Pook, Tejal Kulkarni, Ian A Trounce, Martin F Pera, Martin B Delatycki, Alice Pébay

Journal article  |  2015  |  Biochemistry and Biophysics Reports

We assessed structural elements of the retina in individuals with Friedreich ataxia (FRDA) and in mouse models of FRDA, as well as..

Cardiac Repair With a Novel Population of Mesenchymal Stem Cells Resident in the Human Heart

Yuan Zhang, Priyadharshini Sivakumaran, Andrew E Newcomb, Damian Hernandez, Nicole Harris, Ramin Khanabdali, Guei-Sheung Liu, Darren J Kelly, Alice Pebay, Alex W Hewitt, Andrew Boyle, Richard Harvey, Wayne A Morrison, David A Elliott, Gregory J Dusting, Shiang Y Lim

Journal article  |  2015  |  STEM CELLS

Generation of Integration-free Human Induced Pluripotent Stem Cells Using Hair-derived Keratinocytes

Sandy SC Hung, Alice Pebay, Raymond CB Wong

Journal article  |  2015  |  Journal of Visualized Experiments

DECREASED ANTI-REGENERATIVE EFFECTS AFTER SPINAL CORD INJURY IN SPRY4-/- MICE

Y Goldshmit, F Frisca, J Kaslin, AR Pinto, J-KKY Tang, A Pebay, R Pinkas-Kramarski, PD Currie

Journal article  |  2015  |  Neuroscience

Cell and Gene Therapy for Friedreich Ataxia: Progress to Date

Marguerite V Evans-Galea, Alice Pebay, Mirella Dottori, Louise A Corben, Sze Hwee Ong, Paul J Lockhart, Martin B Delatycki

Journal article  |  2014  |  Human Gene Therapy

Human Pluripotent Stem Cell Strategies for Age-Related Macular Degeneration

Kathryn C Davidson, Robyn H Guymer, Martin F Pera, Alice Pebay

Journal article  |  2014  |  Optometry and Vision Science

Methods of Retinal Ganglion Cell Differentiation From Pluripotent Stem Cells

Katherine P Gill, Alex W Hewitt, Kathryn C Davidson, Alice Pebay, Raymond CB Wong

Journal article  |  2014  |  Translational Vision Science & Technology

Complexities of lysophospholipid signalling in glioblastoma

Wayne Ng, Alice Pebay, Katharine Drummond, Antony Burgess, Andrew H Kaye, Andrew Morokoff

Journal article  |  2014  |  Journal of Clinical Neuroscience

Methods of Retinal Ganglion Cell Differentiation From Pluripotent Stem Cells

Katherine P Gill, Alex W Hewitt, Kathryn C Davidson, Alice Pébay, Raymond CB Wong

Journal article  |  2014  |  Translational Vision Science & Technology

Role of lysophosphatidic acid in traumatic brain injury: anti-LPA antibodies are neuroprotective after experimental TBI

Jonathan Wojciak, Roger Sabbadini, Peter Crack, Cristina Morganti-Kossmann, Moses Zhang, Alice Pebay, Alison Conquest, Andrew Morris

Conference Proceedings  |  2014  |  FASEB JOURNAL

Fgf2 improves functional recovery-decreasing gliosis and increasing radial glia and neural progenitor cells after spinal cord injury

Yona Goldshmit, Frisca Frisca, Alexander R Pinto, Alice Pebay, Jean-Kitty KY Tang, Ashley L Siegel, Jan Kaslin, Peter D Currie

Journal article  |  2014  |  Brain and Behavior

Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes

Peter J Crack, Moses Zhang, Maria Cristina Morganti-Kossmann, Andrew J Morris, Jonathan M Wojciak, Jonathan K Fleming, Ila Karve, David Wright, Maithili Sashindranath, Yona Goldshmit, Alison Conquest, Maria Daglas, Leigh A Johnston, Robert L Medcalf, Roger A Sabbadini, Alice Pebay

Journal article  |  2014  |  Journal of neuroinflammation

HOW TO MEND A BROKEN HEART - BUILDING VASCULARISED HUMAN CARDIAC TISSUE FROM STEM CELLS IN VIVO

GJ Dusting, D Hemandez, P Sivakumaran, D Crombie, A Pebay, SY Lim

Conference Proceedings  |  2013  |  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Trichostatin A Enhances Differentiation of Human Induced Pluripotent Stem Cells to Cardiogenic Cells for Cardiac Tissue Engineering

Shiang Y Lim, Priyadharshini Sivakumaran, Duncan E Crombie, Gregory J Dusting, Alice Pebay, Rodney J Dilley

Journal article  |  2013  |  Stem Cells Translational Medicine

Growth Factors and the Serum-Free Culture of Human Pluripotent Stem Cells

A Pébay, MF Pera

Book Chapter  |  2013

Lysophosphatidic acid signalling in neural stem/progenitor cells and in neurotrauma

A Pebay, F Frisca, PJ Crack, D Crombie, R Sabbadini, Y Goldshmit

Conference Proceedings  |  2013  |  JOURNAL OF NEUROCHEMISTRY

Rho/ROCK pathway is essential to the expansion, differentiation, and morphological rearrangements of human neural stem/progenitor cells induced by lysophosphatidic acid

Frisca Frisca, Duncan E Crombie, Mirella Dottori, Yona Goldshmit, Alice Pebay

Journal article  |  2013  |  Journal of Lipid Research

Pluripotent stem cell-based models to investigate retinal pigmented epithelium function and disease

DE Crombie, A Pébay, RH Guymer, KC Davidson

Journal article  |  2013  |  Drug Discovery Today

Blockage of Lysophosphatidic Acid Signaling Improves Spinal Cord Injury Outcomes

Yona Goldshmit, Rosalia Matteo, Tamar Sztal, Felix Ellett, Frisca Frisca, Kelli Moreno, Duncan Crombie, Graham J Lieschke, Peter D Currie, Roger A Sabbadini, Alice Pebay

Journal article  |  2012  |  American Journal of Pathology

In vivo tissue engineering chamber supports human induced pluripotent stem cell survival and rapid differentiation

Shiang Y Lim, Dcing Geun Lee, Priyadharshini Sivakumaran, Duncan Crombie, John Slavin, Mirella Dottori, Brock Conley, Mark Denham, Jessie Leung, Richard Tee, Gregory J Dusting, Alice Pebay, Rodney J Dilley

Journal article  |  2012  |  Biochemical and Biophysical Research Communications

Maintenance of human embryonic stem cells by sphingosine-1-phosphate and platelet-derived growth factor.

Raymond CB Wong, Martin F Pera, Alice Pébay

Book Chapter  |  2012  |  Methods in Molecular Biology

Embryonic stem cells are pluripotent and capable of indefinite self-renewal in vitro. Human embryonic stem cells (hESC) have gener..

BIOLOGICAL EFFECTS OF LYSOPHOSPHATIDIC ACID IN THE NERVOUS SYSTEM

Frisca Frisca, Roger A Sabbadini, Yona Goldshmit, Alice Pebay

Journal article  |  2012  |  International review of cell and molecular biology

Acute effect of endothelins on intercellular communication of human embryonic stem cells

RCB Wong, KC Davidson, J Leung, MF Pera, A Pébay

Book Chapter  |  2011

Generation of Induced Pluripotent Stem Cell Lines from Friedreich Ataxia Patients

Jun Liu, Paul J Verma, Marguerite V Evans-Galea, Martin B Delatycki, Anna Michalska, Jessie Leung, Duncan Crombie, Joseph P Sarsero, Robert Williamson, Mirella Dottori, Alice Pebay

Journal article  |  2011  |  Stem Cell Reviews and Reports

Modulation of LPA Receptor Expression in the Human Brain Following Neurotrauma

Tony Frugier, Duncan Crombie, Alison Conquest, Frisca Tjhong, Caroline Taylor, Tejal Kulkarni, Catriona McLean, Alice Pebay

Journal article  |  2011  |  Cellular & Molecular Neurobiology

Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells

Caitlin E Filby, Robert Williamson, Peter van Kooy, Alice Pebay, Mirella Dottori, Ngaire J Elwood, Faten Zaibak

Journal article  |  2011  |  Stem Cell Research & Therapy

Non-classical Signalling Mechanisms in Stem Cells

Alice Pebay, Hitesh Peshavariya, Raymond C.B., Gregory J

Book Chapter  |  2011

Late Passage Human Fibroblasts Induced to Pluripotency Are Capable of Directed Neuronal Differentiation

Jun Liu, Huseyin Sumer, Jessie Leung, Kyle Upton, Mirella Dottori, Alice Pebay, Paul J Verma

Journal article  |  2011  |  Cell Transplantation

Molecular mechanism involved in the maintenance of pluripotent stem cells.

Raymond Ching-Bong Wong, Peter J Donovan, Alice Pébay

Book Chapter  |  2011  |  Journal of Stem Cells

The idea of growing human cells in vitro to yield a renewable source of cells for transplantation has captured the imagination of ..

Gli1 Is an Inducing Factor in Generating Floor Plate Progenitor Cells from Human Embryonic Stem Cells

Mark Denham, Lachlan H Thompson, Jessie Leung, Alice Pebay, Anders Bjorklund, Mirella Dottori

Journal article  |  2010  |  Stem Cells

G-protein Coupled Receptors in Stem Cell Self-Renewal and Differentiation

Nao R Kobayashi, Susan M Hawes, Jeremy M Crook, Alice Pebay

Journal article  |  2010  |  Stem Cell Reviews and Reports

LPA receptor expression in the central nervous system in health and following injury

Yona Goldshmit, Kathryn Munro, Soo Yuen Leong, Alice Pebay, Ann M Turnley

Journal article  |  2010  |  Cell and Tissue Research

Study of gap junctions in human embryonic stem cells.

Raymond CB Wong, Alice Pébay

Book Chapter  |  2010  |  Methods in Molecular Biology

Gap junctional intercellular communication (GJIC) has been described in different cell types including stem cells and has been inv..

Neural Differentiation of Human Embryonic Stem Cells

Mirella Dottori, Alice Pebay, Martin F Pera

Book Chapter  |  2010

Study of Gap Junctions in Human Embryonic Stem Cells

Raymond CB Wong, Alice Pebay

Book Chapter  |  2010  |  Methods in Molecular Biology

MOLECULAR MECHANISM INVOLVED IN THE MAINTENANCE OF PLURIPOTENT STEM CELLS

Raymond Ching-Bong Wong, Peter J Donovan, Alice Pebay

Book Chapter  |  2010

Small-Molecule Induction of Neural Crest-like Cells Derived from Human Neural Progenitors

Ryo Hotta, Lana Pepdjonovic, Richard B Anderson, Dongcheng Zhang, Annette J Bergner, Jessie Leung, Alice Pebay, Heather M Young, Donald F Newgreen, Mirella Dottori

Journal article  |  2009  |  Stem Cells

A New Feeder-Free Technique to Expand Human Embryonic Stem Cells and Induced Pluripotent Stem Cells

Mark Denham, Jessie Leung, Cheryl Tay, Raymond CB Wong, Peter Donovan, Mirella Dottori, Alice Pebay

Journal article  |  2009  |  The Open Stem Cell Journal

Small molecule induction of neural crest stem cells from human embryonic stem cell-derived neural progenitor cells

R Hotta, L Pepdjonovic, RB Anderson, D Zhang, AJ Bergner, J Leung, A Pebay, M Dottori, HM Young, DF Newgreen

Conference Proceedings  |  2009  |  NEUROGASTROENTEROLOGY AND MOTILITY

Growth Factors and the Serum-free Culture of Human Pluripotent Stem Cells

Alice Pebay, Martin F Pera

Book Chapter  |  2009

Acute effect of endothelins on intercellular communication of human embryonic stem cells.

Raymond CB Wong, Kathryn C Davidson, Jessie Leung, Martin F Pera, Alice Pébay

Journal article  |  2009  |  Journal of Stem Cells

Endothelin (ET) family comprises three isoforms, ET-1, ET-2 and ET-3 that bind to two receptors ET-A and ET-B. Upon hESC different..

Regulation of Stem Cell Pluripotency and Neural Differentiation by Lysophospholipids

Stuart M Pitson, Alice Pebay

Journal article  |  2009  |  Neurosignals

Growth Factors and the Serum-free Culture of Human Pluripotent Stem Cells

A PEBAY, undefined Pera

Book Chapter  |  2009

Human embryonic stem cells: Key characteristics and main applications in disease research

KC Davidsond, M Dottori, A Pébay

Book Chapter  |  2008

Role of Gap Junctions in Embryonic and Somatic Stem Cells

Raymond CB Wong, Martin F Pera, Alice Pebay

Journal article  |  2008  |  Stem Cell Reviews and Reports

Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells

Mirella Dottori, Jessie Leung, Ann M Turnley, Alice Pebay

Journal article  |  2008  |  Stem Cells

Signaling pathways involved in the maintenance of human embryonic stem cells.

undefined Wong, A PEBAY

Book Chapter  |  2008

Anti-apoptotic effect of sphingosine-1-phosphate and platelet-derived growth factor in human embryonic stem cells

Raymond CB Wong, Irene Tellis, Pegah Jamshidi, Martin Pera, Alice Pebay

Journal article  |  2007  |  Stem Cells and Development

Stem cell regulation by lysophospholipids

Alice Pebay, Claudine S Bonder, Stuart M Pitson

Journal article  |  2007  |  Prostaglandins & Other Lipid Mediators

(WO/2007/012144) COMPOSITIONS AND METHODS FOR GROWTH OF PLURIPOTENT CELLS

A PEBAY, A Michalska, M Pera

Patent  |  2007

Signaling pathways involved in the maintenance of human embryonic stem cells

RCB Wong, A Pébay

Journal article  |  2006  |  Journal of Stem Cells

Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system

RCB Wong, M Dottori, KLL Koh, LTV Nguyen, MF Pera, A Pebay

Journal article  |  2006  |  Biochemical and Biophysical Research Communications

S1P inhibits gap junctions in astrocytes: involvement of G(i) and Rho GTPase/ROCK

N Rouach, A Pebay, W Meme, J Cordier, P Ezan, E Etienne, C Giaume, M Tence

Journal article  |  2006  |  European Journal of Neuroscience

A role for Neurotrophins in embryonic stem cell growth

A Trounson, A Pebay

Journal article  |  2006  |  Developmental Cell

Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells

A Pebay, RCB Wong, SM Pitson, EJ Wolvetang, GSL Peh, A Filipczyk, KLL Koh, I Tellis, LTV Nguyen, MF Pera

Journal article  |  2005  |  Stem Cells

Growth Factors and the Serum-free Culture of Human Pluripotent Stem Cells

A Pébay, MF Pera

Book Chapter  |  2004

Presence of functional gap junctions in human embryonic stem cells

RCB Wong, A Pebay, LTV Nguyen, KLL Koh, MF Pera

Journal article  |  2004  |  Stem Cells

Methods of regulating differentiation of stem cells

A PEBAY, M Pera

Patent  |  2003

Erratum: Sphingosine-1-phosphate induces proliferation of astrocytes: Regulation by intracellular signalling cascades (European Journal of Neuroscience (2001) 13 (2067-2076))

A Pébay, M Toutant, J Premont, CF Calvo, L Venance, J Cordier, J Glowinski, M Tencé

Journal article  |  2001  |  European Journal of Neuroscience

Antiproliferative properties of sphingosine-1-phosphate in human hepatic myofibroblasts

A Pebay, M Toutant, J Premont, CF Calvo, L Venance, J Cordier, J Glowinski, M Tence

Journal article  |  2001  |  European Journal of Neuroscience

Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades.

A Pébay, M Toutant, J Prémont, CF Calvo, L Venance, J Cordier, J Glowinski, M Tencé

Journal article  |  2001  |  European Journal of Neuroscience

Sphingosine-1-phosphate (S1P) is a potent lysophospholipid mediator mostly released by activated platelets. It is involved in seve..

Pleiotropic effects of lysophosphatidic acid on striatal astrocytes

A Pebay, Y Torrens, M Toutant, J Cordier, J Glowinski, M Tence

Journal article  |  1999  |  Glia