Alice Pebay

Automation of Organoid Cultures: Current Protocols and Applications

Alexandra Louey, Damian Hernandez, Alice Pebay, Maciej Daniszewski

Journal article  |  2021  |  SLAS DISCOVERY

GRAPHICAL ABSTRACT: [Formula: see text].

Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the London mutation in APP (V717I)

Damian Hernandez, Stephanie Morgan Schlicht, Maciej Daniszewski, Celeste M Karch, Alison M Goate, Alice Pebay

Journal article  |  2021  |  STEM CELL RESEARCH

We report the genome-editing of an existing iPSC line carrying the London mutation in APP (V717I) into an iPSC line in which the p..

Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images

Hannah Currant, Pirro Hysi, Tomas W Fitzgerald, Puya Gharahkhani, Pieter WM Bonnemaijer, Anne Senabouth, Alex W Hewitt, Denize Atan, Tin Aung, Jason Charng, Helene Choquet, Jamie Craig, Peng T Khaw, Caroline CW Klaver, Michiaki Kubo, Jue-Sheng Ong, Louis R Pasquale, Charles A Reisman, Maciej Daniszewski, Joseph E Powell, et al.

Journal article  |  2021  |  PLOS GENETICS

Optical Coherence Tomography (OCT) enables non-invasive imaging of the retina and is used to diagnose and manage ophthalmic diseas..

Culture Variabilities of Human iPSC-Derived Cerebral Organoids Are a Major Issue for the Modelling of Phenotypes Observed in Alzheimer's Disease

Damian Hernandez, Louise A Rooney, Maciej Daniszewski, Lerna Gulluyan, Helena H Liang, Anthony L Cook, Alex W Hewitt, Alice Pebay

Journal article  |  2021  |  STEM CELL REVIEWS AND REPORTS

Apolipoprotein E (APOE) is the most important susceptibility gene for late onset of Alzheimer's disease (AD), with the presence of..

Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells

Drew Neavin, Quan Nguyen, Maciej S Daniszewski, Helena H Liang, Han Sheng Chiu, Yong Kiat Wee, Anne Senabouth, Samuel W Lukowski, Duncan E Crombie, Grace E Lidgerwood, Damian Hernandez, James C Vickers, Anthony L Cook, Nathan J Palpant, Alice Pebay, Alex W Hewitt, Joseph E Powell

Journal article  |  2021  |  GENOME BIOLOGY

BACKGROUND: The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) has provided a foundati..

Use of CRISPR/Cas ribonucleoproteins for high throughput gene editing of induced pluripotent stem cells.

Qi Wang, Sueanne Chear, Kristof Wing, David Stellon, Minh Thuan Nguyen Tran, Jana Talbot, Alice Pébay, Alex W Hewitt, Anthony L Cook

Journal article  |  2021  |  Methods

Induced pluripotent stem cells (iPSCs) have become widely used for disease modelling, particularly with regard to predisposing gen..

The Use of Human Pluripotent Stem Cells (hPSCs) and CRISPR-Mediated Gene Editing in Retinal Diseases

Grace E Lidgerwood, Alex W Hewitt, Alice Pébay, Damián Hernández

Book Chapter  |  2021

Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.

Grace E Lidgerwood, Anne Senabouth, Casey JA Smith-Anttila, Vikkitharan Gnanasambandapillai, Dominik C Kaczorowski, Daniela Amann-Zalcenstein, Erica L Fletcher, Shalin H Naik, Alex W Hewitt, Joseph E Powell, Alice Pébay

Journal article  |  2020  |  Genomics Proteomics Bioinformatics

Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells, presenting a potential limitation to the accu..

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

Lezanne Ooi, Mirella Dottori, Anthony L Cook, Martin Engel, Vini Gautam, Alexandra Grubman, Damian Hernandez, Anna E King, Simon Maksour, Helena Targa Dias Anastacio, Rachelle Balez, Alice Pebay, Colin Pouton, Michael Valenzuela, Anthony White, Robert Williamson

Journal article  |  2020  |  The Neuroscientist

Because our beliefs regarding our individuality, autonomy, and personhood are intimately bound up with our brains, there is a publ..

Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing

Minh Thuan Nguyen Tran, Mohd Khairul Nizam Mohd Khalid, Qi Wang, Jacqueline KR Walker, Grace E Lidgerwood, Kimberley L Dilworth, Leszek Lisowski, Alice Pebay, Alex W Hewitt

Journal article  |  2020  |  NATURE COMMUNICATIONS

Precision genome engineering has dramatically advanced with the development of CRISPR/Cas base editing systems that include cytosi..