Alice Pebay

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

Lezanne Ooi, Mirella Dottori, Anthony L Cook, Martin Engel, Vini Gautam, Alexandra Grubman, Damian Hernandez, Anna E King, Simon Maksour, Helena Targa Dias Anastacio, Rachelle Balez, Alice Pebay, Colin Pouton, Michael Valenzuela, Anthony White, Robert Williamson

Journal article  |  2020  |  The Neuroscientist

Because our beliefs regarding our individuality, autonomy, and personhood are intimately bound up with our brains, there is a publ..

Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing

Minh Thuan Nguyen Tran, Mohd Khairul Nizam Mohd Khalid, Qi Wang, Jacqueline KR Walker, Grace E Lidgerwood, Kimberley L Dilworth, Leszek Lisowski, Alice Pebay, Alex W Hewitt

Journal article  |  2020  |  Nature Communications

Precision genome engineering has dramatically advanced with the development of CRISPR/Cas base editing systems that include cytosi..

Comparison of CRISPR/Cas Endonucleases forin vivoRetinal Gene Editing

Fan Li, Kristof Wing, Jiang-Hui Wang, Chi D Luu, James A Bender, Jinying Chen, Qi Wang, Qinyi Lu, Minh Thuan Nguyen Tran, Kaylene M Young, Raymond CB Wong, Alice Pebay, Anthony L Cook, Sandy SC Hung, Guei-Sheung Liu, Alex W Hewitt

Journal article  |  2020  |  Frontiers in Cellular Neuroscience

A Simple Differentiation Protocol for Generation of Induced Pluripotent Stem Cell-Derived Basal Forebrain-Like Cholinergic Neurons for Alzheimer's Disease and Frontotemporal Dementia Disease Modeling.

Sonia Sanz Muñoz, Martin Engel, Rachelle Balez, Dzung Do-Ha, Mauricio Castro Cabral-da-Silva, Damian Hernández, Tracey Berg, Jennifer A Fifita, Natalie Grima, Shu Yang, Ian P Blair, Garth Nicholson, Anthony L Cook, Alex W Hewitt, Alice Pébay, Lezanne Ooi

Journal article  |  2020  |  Cells

The study of neurodegenerative diseases using pluripotent stem cells requires new methods to assess neurodevelopment and neurodege..

Genotype-free demultiplexing of pooled single-cell RNA-seq

Jun Xu, Caitlin Falconer, Quan Nguyen, Joanna Crawford, Brett D McKinnon, Sally Mortlock, Anne Senabouth, Stacey Andersen, Han Sheng Chiu, Longda Jiang, Nathan J Palpant, Jian Yang, Michael D Mueller, Alex W Hewitt, Alice Pebay, Grant W Montgomery, Joseph E Powell, Lachlan JM Coin

Journal article  |  2019  |  Genome Biology

A variety of methods have been developed to demultiplex pooled samples in a single cell RNA sequencing (scRNA-seq) experiment whic..

Differentiation of Retinal Glial Cells From Human Embryonic Stem Cells by Promoting the Notch Signaling Pathway

Sook Hyun Chung, Weiyong Shen, Kathryn C Davidson, Alice Pebay, Raymond CB Wong, Belinda Yau, Mark Gillies

Journal article  |  2019  |  Frontiers in Cellular Neuroscience

Optimization of silk fibroin membranes for retinal implantation

Shuko Suzuki, Audra MA Shadforth, Samuel McLenachan, Dan Zhang, Shang-Chih Chen, Jennifer Walshe, Grace E Lidgerwood, Alice Pebay, Traian Chirila, Fred K Chen, Damien G Harkin

Journal article  |  2019  |  Materials Science and Engineering: C

Utility of Self-Destructing CRISPR/Cas Constructs for Targeted Gene Editing in the Retina

Fan Li, Sandy SC Hung, Mohd Khairul Nizam Mohd Khalid, Jiang-Hui Wang, Vicki Chrysostomou, Vickie HY Wong, Vikrant Singh, Kristof Wing, Leilei Tu, James A Bender, Alice Pebay, Anna E King, Anthony L Cook, Raymond CB Wong, Bang Bui, Alex W Hewitt, Guei-Sheung Liu

Journal article  |  2019  |  Human Gene Therapy

PSEN1 Delta E9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Henna Konttinen, Mauricio E Castro Cabral-da-Silva, Sohvi Ohtonen, Sara Wojciechowski, Anastasia Shakirzyanova, Simone Caligola, Rosalba Giugno, Yevheniia Ishchenko, Damian Hernandez, Mohammad Feroze Fazaludeen, Shaila Eamen, Mireia Gomez Budia, Ilkka Fagerlund, Flavia Scoyni, Paula Korhonen, Nadine Huber, Annakaisa Haapasalo, Alex W Hewitt, James Vickers, Grady C Smith, et al.

Journal article  |  2019  |  Stem Cell Reports

Human pluripotent stem cells for the modelling of diseases of the retina and optic nerve: toward a retina in a dish

Grace E Lidgerwood, Alex W Hewitt, Alice Pebay

Journal article  |  2019  |  Current Opinion in Pharmacology

Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retin..