Maree Faux

Dual drug targeting to kill colon cancers.

Silvia Paola Corona, Francesca Walker, Janet Weinstock, Guillaume Lessene, Maree Faux, Antony W Burgess

Journal article  |  2022  |  Cancer Med

INTRODUCTION: Colorectal cancer (CRC) is driven by a small set of oncogenic and tumour suppressor mutations. However, different co..

Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes

Ryan F Leung, Ankita M George, Enola M Roussel, Maree C Faux, Jeffrey T Wigle, David D Eisenstat

Journal article  |  2022  |  FRONTIERS IN NEUROSCIENCE

Forebrain development in vertebrates is regulated by transcription factors encoded by homeobox, bHLH and forkhead gene families th..

Combined Treatment with a WNT Inhibitor and the NSAID Sulindac Reduces Colon Adenoma Burden in Mice with Truncated APC.

Maree C Faux, Janet Weinstock, Sophia Gogos, Emma Prato, Alexander I Azimpour, Ryan O'Keefe, Yasmin Cathcart-King, Alexandra L Garnham, Matthias Ernst, Adele Preaudet, Michael Christie, Tracy L Putoczki, Michael Buchert, Antony W Burgess

Journal article  |  2022  |  Cancer Res Commun

UNLABELLED: Adenomatous polyposis coli (APC) truncations occur in many colorectal cancers and are often associated with immune inf..

Low-viscosity matrix suspension culture enables scalable analysis of patient-derived organoids and tumoroids from the large intestine

Yumiko Hirokawa, Jordan Clarke, Michelle Palmieri, Tao Tan, Dmitri Mouradov, Shan Li, Cong Lin, Fuqiang Li, Huijuan Luo, Kui Wu, Maree Faux, Chin Wee Tan, Margaret Lee, Grace Gard, Peter Gibbs, Antony W Burgess, Oliver M Sieber

Journal article  |  2021  |  COMMUNICATIONS BIOLOGY

Cell embedment into a solid support matrix is considered essential for the culture of intestinal epithelial organoids and tumoroid..

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

Christoph Grohmann, Francesca Walker, Mark Devlin, Meng-Xiao Luo, Anderly C Chueh, Judy Doherty, Francois Vaillant, Gwo-Yaw Ho, Matthew J Wakefield, Clare E Weeden, Alvin Kamili, Jayne Murray, Sela T Po'uha, Janet Weinstock, Serena R Kane, Maree C Faux, Esmee Broekhuizen, Ye Zheng, Kristy Shield-Artin, Nadia J Kershaw, et al.

Journal article  |  2021  |  CELL DEATH & DISEASE

Targeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limita..

APC regulation of ESRP1 and p120-catenin isoforms in colorectal cancer cells

Maree C Faux, Lauren E King, Serena R Kane, Christopher Love, Oliver M Sieber, Antony W Burgess

Journal article  |  2021  |  MOLECULAR BIOLOGY OF THE CELL

The adenomatous polyposis coli (APC) tumor suppressor protein is associated with the regulation of Wnt signaling; however, APC als..

Genes regulating membrane-associated E-cadherin and proliferation in adenomatous polyposis coli mutant colon cancer cells: High content siRNA screen

Lauren E King, Hui-Hua Zhang, Cathryn M Gould, Daniel W Thomas, Lachlan W Whitehead, Kaylene J Simpson, Antony W Burgess, Maree C Faux

Journal article  |  2020  |  PLOS ONE

Truncating mutations in the tumour suppressor gene APC occur frequently in colorectal cancers and result in the deregulation of Wn..

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

Andre L Samson, Ying Zhang, Niall D Geoghegan, Xavier J Gavin, Katherine A Davies, Michael J Mlodzianoski, Lachlan W Whitehead, Daniel Frank, Sarah E Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N Young, Annette V Jacobsen, Wayne Cawthorne, Emma J Petrie, Maree C Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M Hildebrand, John Silke, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-medi..

Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Mayur Garg, Simon G Royce, Chris Tikellis, Claire Shallue, Duygu Batu, Elena Velkoska, Louise M Burrell, Sheila K Patel, Lauren Beswick, Anvesh Jackson, Kaushali Britto, Matthew Lukies, Pavel Sluka, Hady Wardan, Yumiko Hirokawa, Chin Wee Tan, Maree Faux, Antony W Burgess, Patrick Hosking, Shaun Monagle, et al.

Journal article  |  2020  |  GUT

OBJECTIVE: We evaluated the influence of the renin-angiotensin system (RAS) on intestinal inflammation and fibrosis. DESIGN: Cultu..

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress

Frances L Byrne, Ellen M Olzomer, Gabriella R Marriott, Lake-Ee Quek, Alice Katen, Jacky Su, Marin E Nelson, Gene Hart-Smith, Mark Larance, Veronica F Sebesfi, Jeff Cuff, Gabriella E Martyn, Elizabeth Childress, Stephanie J Alexopoulos, Ivan K Poon, Maree C Faux, Antony W Burgess, Glen Reid, Joshua A McCarroll, Webster L Santos, et al.

Journal article  |  2020  |  REDOX BIOLOGY

A hallmark of cancer cells is their ability to reprogram nutrient metabolism. Thus, disruption to this phenotype is a potential av..