Susan Nilsson

Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells.

Xuan Sun, Benjamin Cao, Marina Naval-Sanchez, Tony Pham, Yu Bo Yang Sun, Brenda Williams, Shen Y Heazlewood, Nikita Deshpande, Jinhua Li, Felix Kraus, James Rae, Quan Nguyen, Hamed Yari, Jan Schröder, Chad K Heazlewood, Madeline Fulton, Jessica Hatwell-Humble, Kaustav Das Gupta, Ronan Kapetanovic, Xiaoli Chen, et al.

Journal article  |  2021  |  Nat Commun

With age, hematopoietic stem cells (HSC) undergo changes in function, including reduced regenerative potential and loss of quiesce..

Potent In Vitro Peptide Antagonists of the Thrombopoietin Receptor as Potential Myelofibrosis Drugs

Monika Szabo, Wioleta Kowalczyk, Anna Tarasova, Jessica Andrade, Cheang Ly Be, Roger Mulder, Jacinta White, Adam G Meyer, Kjiana E Schwab, Kellie Cartledge, Tu C Le, Anoja Wickrama Arachchilage, Xiaoli Wang, Ronald Hoffman, Susan K Nilsson, David N Haylock, David A Winkler

Journal article  |  2021  |  ADVANCED THERAPEUTICS

Myelofibrosis (MF) is a life-threatening blood cancer, with current drugs providing only symptomatic relief without altering the c..

Glycosylated Nanoparticles Derived from RAFT Polymerization for Effective Drug Delivery to Macrophages

James L Rushworth, Katherine S Montgomery, Benjamin Cao, Robert Brown, Nick J Dibb, Susan K Nilsson, John Chiefari, Matthew J Fuchter

Journal article  |  2020  |  ACS APPLIED BIO MATERIALS

The functional group tolerance and simplicity of reversible addition fragmentation chain transfer (RAFT) polymerization enable its..

Reprogramming roadmap reveals route to human induced trophoblast stem cells

Xiaodong Liu, John F Ouyang, Fernando J Rossello, Jia Ping Tan, Kathryn C Davidson, Daniela S Valdes, Jan Schroeder, Yu BY Sun, Joseph Chen, Anja S Knaupp, Guizhi Sun, Hun S Chy, Ziyi Huang, Jahnvi Pflueger, Jaber Firas, Vincent Tano, Sam Buckberry, Jacob M Paynter, Michael R Larcombe, Daniel Poppe, et al.

Journal article  |  2020  |  Nature

The reprogramming of human somatic cells to primed or naive induced pluripotent stem cells recapitulates the stages of early embry..

A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture.

Alexandra Grubman, Teresa H Vandekolk, Jan Schröder, Guizhi Sun, Jessica Hatwell-Humble, Jonathan Chan, Minna Oksanen, Sarka Lehtonen, Cameron Hunt, Jari E Koistinaho, Susan K Nilsson, John M Haynes, Colin W Pouton, Jose M Polo

Journal article  |  2020  |  Stem Cell Reports

Multiple protocols have been published for generation of iMGLs from hESCs/iPSCs. To date, there are no guides to assist researcher..

Smad4 promotes diabetic nephropathy by modulating glycolysis and OXPHOS

Jinhua Li, Yu Bo Yang Sun, Weiyi Chen, Jinjin Fan, Songhui Li, Xinli Qu, Qikang Chen, Riling Chen, Dajian Zhu, Jinfeng Zhang, Zhuguo Wu, Honggang Chi, Simon Crawford, Viola Oorschot, Victor G Puelles, Peter G Kerr, Yi Ren, Susan K Nilsson, Mark Christian, Huanwen Tang, et al.

Journal article  |  2020  |  EMBO REPORTS

Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease. TGF-β1/Smad3 signalling plays a major pathological rol..

In vitro on-target and selectivity profiling of small-molecule inhibitors of the Myc/Max heterodimeric complex

Sang-Kyu Kim, Richard C Foitzik, Songhui Li, Andrew Vinson, Alex Shmaylov, Karen Jarvis, Susan James, Scott R Walker, Mark York, Benjamin Cao, Susan K Nilsson, Ricky W Johnstone

Conference Proceedings  |  2019  |  MOLECULAR CANCER THERAPEUTICS

Osteopontin is An Important Regulative Component of the Fetal Bone Marrow Hematopoietic Stem Cell Niche

Huimin Cao, Benjamin Cao, Chad K Heazlewood, Melanie Domingues, Xuan Sun, Emmanuel Debele, Narelle E McGregor, Natalie A Sims, Shen Y Heazlewood, Susan K Nilsson

Journal article  |  2019  |  CELLS

Osteopontin (OPN) is an important component in both bone and blood regulation, functioning as a bridge between the two. Previously..

Illustrated State-of-the-Art Capsules of the ISTH 2019 Congress in Melbourne, Australia

Christopher M Ward, Robert K Andrews, Alisa Wolberg, Gregory YH Lip, John Eikelboom, Simon F De Meyer, Alan Mast, Matthew Flick, Tetsumei Urano, Tor Ny, Daniel Cutler, Lining A Ju, Cheng Zhu, Anna M Randi, James S O'Donnell, Sarah H O'Brien, Karin Fijnvandraat, Midori Shima, Amit Nathwani, Jim Luyendyk, et al.

Journal article  |  2019  |  RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS

The 27th Congress of the International Society of Thrombosis and Haemostasis (ISTH) is an international conference held July 6-10,..

Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy.

Mengjie Jiang, Jinjin Fan, Xinli Qu, Songhui Li, Susan K Nilsson, Yu Bo Yang Sun, Yaping Chen, Di Yu, Dan Liu, Bi-Cheng Liu, Mingliang Tang, Wei Chen, Yi Ren, David J Nikolic-Paterson, Xiaoyun Jiang, Jinhua Li, Xueqing Yu

Journal article  |  2019  |  Front Pharmacol

Acute kidney injury leading to chronic kidney disease through tubulointerstitial fibrosis is a major challenge in nephropathy. Sev..