Paul Gooley

Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38

Klara Kirsch, Andras Zeke, Orsolya Toke, Peter Sok, Ashish Sethi, Anna Sebo, Ganesan Senthil Kumar, Peter Egri, Adam L Poti, Paul Gooley, Wolfgang Peti, Isabel Bento, Anita Alexa, Attila Remenyi

Journal article  |  2020  |  Nature Communications

Transcription factor phosphorylation at specific sites often activates gene expression, but how environmental cues quantitatively ..

The Measles Virus V Protein Binding Site to STAT2 Overlaps That of IRF9

Yuma Nagano, Aoi Sugiyama, Madoka Kimoto, Takuya Wakahara, Yasuyo Noguchi, Xinxin Jiang, Shinya Saijo, Nobutaka Shimizu, Nana Yabuno, Min Yao, Paul R Gooley, Gregory W Moseley, Takashi Tadokoro, Katsumi Maenaka, Toyoyuki Ose

Journal article  |  2020  |  Journal of Virology

Structural comparison of the C-terminal domain of functionally divergent lyssavirus P proteins

Aoi Sugiyama, Tomo Nomai, Xinxin Jiang, Miku Minami, Min Yao, Katsumi Maenaka, Naoto Ito, Paul R Gooley, Gregory W Moseley, Toyoyuki Ose

Journal article  |  2020  |  Biochemical and Biophysical Research Communications

INPHARMA-Based Determination of Ligand Binding Modes at alpha(1)-Adrenergic Receptors Explains the Molecular Basis of Subtype Selectivity

Tasneem M Vaid, David K Chalmers, Daniel J Scott, Paul R Gooley

Journal article  |  2020  |  Chemistry - A European Journal

The structural poses of ligands that bind weakly to protein receptors are challenging to define. In this work we have studied liga..

N- and C-terminal regions of ?B-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation

Emily E Selig, Courtney O Zlatic, Dezerae Cox, Yee-Foong Mok, Paul R Gooley, Heath Ecroyd, Michael DW Griffin

Journal article  |  2020  |  Journal of Biological Chemistry

Small heat-shock proteins (sHSPs) are ubiquitously expressed molecular chaperones that inhibit amyloid fibril formation; however, ..

The structure of the extracellular domains of human interleukin 11? receptor reveals mechanisms of cytokine engagement

Riley D Metcalfe, Kaheina Aizel, Courtney O Zlatic, Paul M Nguyen, Craig J Morton, Daisy Sio-Seng Lio, Heung-Chin Cheng, Renwick CJ Dobson, Michael W Parker, Paul R Gooley, Tracy L Putoczki, Michael DW Griffin

Journal article  |  2020  |  Journal of Biological Chemistry

Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex with its cell surface α-receptor, IL-..

Probing the correlation between ligand efficacy and conformational diversity at the ?(1A)-adrenoreceptor reveals allosteric coupling of its microswitches

Feng-Jie Wu, Lisa M Williams, Alaa Abdul-Ridha, Avanka Gunatilaka, Tasneem M Vaid, Martina Kocan, Alice R Whitehead, Michael DW Griffin, Ross AD Bathgate, Daniel J Scott, Paul R Gooley

Journal article  |  2020  |  Journal of Biological Chemistry

G protein–coupled receptors (GPCRs) use a series of conserved microswitches to transmit signals across the cell membrane via an al..

Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

Md Alamgir Hossain, Florence Larrous, Stephen M Rawlinson, Jingyu Zhan, Ashish Sethi, Youssef Ibrahim, Maria Aloi, Kim G Lieu, Yee-Foong Mok, Michael DW Griffin, Naoto Ito, Toyoyuki Ose, Herve Bourhy, Gregory W Moseley, Paul R Gooley

Journal article  |  2019  |  Cell Reports

To evade immunity, many viruses express interferon antagonists that target STAT transcription factors as a major component of path..

THE STRUCTURE OF THE INTERLEUKIN 11 SIGNALLING COMPLEX

Riley D Metcalfe, Kahenia Aizel, Courtney O Zlatic, Paul M Nguyen, Paul R Gooley, Tracy L Putoczki, Michael DW Griffin

Conference Proceedings  |  2019  |  PROTEIN SCIENCE

Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Metabolism Deregulation in ME/CFS Cases

Neil R McGregor, Christopher W Armstrong, Donald P Lewis, Paul R Gooley

Journal article  |  2019  |  Diagnostics