Paul Gooley is an Associate Professor in Biochemistry and Molecular Biology at the University of Melbourne. Paul is expert in solution nuclear magnetic resonance spectroscopy especially applied to proteins.
He trained with Ray Norton at the University of New South Wales before going to the USA for postdoctoral studies with Ian Armitage at Yale and Neil MacKenzie at the University of Arizona. He worked at Merck and Co. in a structural biology group before returning to Australia in 1996 to form his research group at the University of Melbourne. He played a critical role in establishing the NMR facility (cave) at the Bio21 Institute in preparing ARC LIEF grants for the 600 and 700 MHz biological spectrometers. He applies NMR techniques to understand how proteins work focusing on defining ligand binding sites and understanding the conformational changes that occur on ligand binding. Current interests are in the molecular mechanism of activation of G-protein coupled receptors, especially the relaxin receptor (RXFP1), and the structure and function of lyssavirus (rabies) proteins, particularly the intrinsically disordered P-protein and its role in suppressing the innate immune response.
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Paul Gooley's highlights
FEATURED Journal article
N- and C-terminal regions of αB-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation.
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Project Types
31
Research Grant
4
Internal Research Grant
1
Research Contracts
Scholarly Works
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Credentials
Positions
Professor And Reader
Biochemistry And Molecular Biology
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Australian and New Zealand Society for Magnetic Resonance
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Australian Socciety for Biochemistry and Molecular Biology
Education
Doctor of Philosophy
University of New South Wales
Bachelor of Science
University of New South Wales