Prof Paul Gooley

Paul Gooley is an Associate Professor in Biochemistry and Molecular Biology at the University of Melbourne. Paul is expert in solution nuclear magnetic resonance spectroscopy especially applied to proteins.

He trained with Ray Norton at the University of New South Wales before going to the USA for postdoctoral studies with Ian Armitage at Yale and Neil MacKenzie at the University of Arizona. He worked at Merck and Co. in a structural biology group before returning to Australia in 1996 to form his research group at the University of Melbourne. He played a critical role in establishing the NMR facility (cave) at the Bio21 Institute in preparing ARC LIEF grants for the 600 and 700 MHz biological spectrometers. He applies NMR techniques to understand how proteins work focusing on defining ligand binding sites and understanding the conformational changes that occur on ligand binding. Current interests are in the molecular mechanism of activation of G-protein coupled receptors, especially the relaxin receptor (RXFP1), and the structure and function of lyssavirus (rabies) proteins, particularly the intrinsically disordered P-protein and its role in suppressing the innate immune response.

Find out more about Paul Gooley's experience

Paul Gooley's highlights

FEATURED Journal article

Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

Paul Gooley's selected work

Molecular Determinants Of Drug Binding And Selectivity At Muscarinic Acetylcholine Recepto..

Research Grant

Chronic fatigue syndrome a kick in the guts

NEWS ARTICLE

THE STRUCTURE OF THE INTERLEUKIN 11 SIGNALLING COMPLEX

Conference Proceedings

Curation Of A Large-Scale Metabolite Dataset Via A Standardised Nmr Metabolomic Resource

Research Grant

Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Met..

Journal article

Resolving And Targeting The Complex Molecular Mechanisms Underlying Gpcr Signalling

Research Grant

Projects

Displaying the 36 most recent projects by Paul Gooley.

Molecular Determinants Of Drug Binding And Selectivity At Muscarinic Acetylcholine Receptors

G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors in the human genome, and drugs targeting these receptor..

2018 - 2021

Active

Curation Of A Large-Scale Metabolite Dataset Via A Standardised Nmr Metabolomic Resource

2018 - 2018

Completed

Resolving And Targeting The Complex Molecular Mechanisms Underlying Gpcr Signalling

Receptors are located on the surface of all human cells to allow our cells to respond to their environment. Over 30% of prescription drugs a..

2018 - 2021

Active

Defining The Molecular Mechanisms Of Lyssavirus Replication And Immune Evasion: The P Protein Axis

Lyssaviruses such as rabies virus (RABV) and Australian bat lyssavirus cause rabies disease, which has the highest case-fatality rate of kno..

2017 - 2021

Active

Preparative High Performance Liquid Chromatography System

2016 - 2017

Completed

Distributed Facility For Fragment Based Drug Discovery

The facility aims to provide researchers with the ability to generate small molecules that modulate therapeutically and biologically importa..

2016 - 2016

Completed

Distributed Facility For Fragment Based Drug Discovery

The facility aims to provide researchers with the ability to generate small molecules that modulate therapeutically and biologically importa..

2016 - 2017

Completed

Unravelling The Binding And Activation Mechanism Of A Complex G Protein-Coupled Receptor

The peptide hormone relaxin is currently in a Phase III trial for the treatment of heart failure. However the peptide is not a good drug as ..

2016 - 2019

Completed

Unravelling The Binding And Activation Mechanism Of A Complex G Protein-Coupled Receptor

The peptide hormone relaxin is currently in a Phase III trial for the treatment of heart failure. However the peptide is not a good drug as ..

2016 - 2019

Completed

A Longitudinal Study Of Gene Expression And Metabolic Profiling Changes That Occur In Chronic Fatigue Syndrome.

2016 - 2018

Completed

Novel Approaches To Understanding Peptide G-Protein-Coupled Receptor Activation

G protein-coupled receptors (GPCRs) are proteins that exist on every human cell, where they sense, and respond to environmental stimuli. Bec..

2015 - 2017

Completed

Novel Approaches To Understanding Peptide G-Protein-Coupled Receptor Activation

G protein-coupled receptors (GPCRs) are proteins that exist on every human cell, where they sense, and respond to environmental stimuli. Bec..

2015 - 2017

Completed

Interrogating Peptide Receptor Targets

The neuropeptide relaxin-3 and the peptide hormone INSL5 are recently discovered members of the relaxin peptide family. Relaxin-3 has import..

2014 - 2016

Completed

Interrogating Peptide Receptor Targets

The neuropeptide relaxin-3 and the peptide hormone INSL5 are recently discovered members of the relaxin peptide family. Relaxin-3 has import..

2014 - 2016

Completed

A Comprehensive Metabolomic Profile Of Chronic Fatigue Syndrome.

2013 - 2014

Completed

Determining Modes Of Binding And Activation Of Complex G-Protein Coupled Receptor Targets

The peptide hormones relaxin is currently in a Phase III trial for the treatment of heart failure. However the peptide is not a good drug as..

2013 - 2015

Completed

Determining Modes Of Binding And Activation Of Complex G-Protein Coupled Receptor Targets

The peptide hormones relaxin is currently in a Phase III trial for the treatment of heart failure. However the peptide is not a good drug as..

2013 - 2015

Completed

Defining The Interface Between An Essential Activating Protein Module And The G-Protein Coupled Receptor Rxfp1 By Solution Nmr

2012 - 2013

Completed

A 700 Mhz Nmr Spectrometer For The Melbourne Biomolecular Nmr Network: A High Throughput Resource

The Melbourne Biomolecular Nuclear Magnetic Resonance (NMR) Network will enable NMR experiments aimed at discovering new molecules for diagn..

2012 - 2012

Completed

Using Protein Dynamics To Identify Novel Pathways Of Activation Of The Diabetes Enzyme Target Ampk

2012 - 2013

Completed

Advanced Characterisation Of Materials By Nuclear Magnetic Resonance

Advanced characterisation of materials by nuclear magnetic resonance will support a broad range of research possibilities for development of..

2011 - 2012

Completed

Explaining The Differences In Affinity And Of Carbohydrate Binding Of The Glycogen-Sensing Enzyme, Ampk

This project will provide fundamental molecular knowledge of how a complex enzyme, AMPK is controlled by the major sugar molecule, glycogen...

2011 - 2014

Completed

Metabolomics Of Chronic Fatigue Syndrome

2011 - 2012

Completed

Metabolomics Of The Gut Microbiota: Role In Health And The Influence Of Supplemented Diets

2010 - 2013

Completed

Functional Analysis Of Relaxin And Insl3 Receptors

The peptide hormone relaxin is currently in clinical trials to treat acute heart failure. The related hormone INSL3 has important roles in f..

2010 - 2012

Completed

Functional Analysis Of Relaxin And Insl3 Receptors

The peptide hormone relaxin is currently in clinical trials to treat acute heart failure. The related hormone INSL3 has important roles in f..

2010 - 2012

Completed

Investigating The Subunit Interactions Of A Molecular Protein Import Machine

The project will provide fundamental knowledge of how sophisticated natural molecular machines interact with their substrates in plants and ..

2008 - 2010

Completed

Relaxin Family Peptide Receptors

Relaxin is a hormone which has long been known to have essential roles in pregnancy and birth. However it has also been demonstrated to have..

2007 - 2009

Completed

The Role Of Lipids In Protein Misfolding And Amyloid-Related Diseases

Membrane Protein Structure And Interaction Facility

While it is estimated that a third of the human genome encodes for membrane proteins, the structures of only relatively few membrane protein..

Evolution, Structure And Function Of Key Components In A Molecular Machine

The project will provide the basis for training of students and personnel in the previously recognized priority "Genomes-Phenomes", still th..

Structural Investigations Of The Mitochondrial Protein Import Receptor Complex

Apolipoproteins And Amyloid Formation In Atheroma

We propose to study the poorly understood, disease-associated process of amyloid formation, using a sensitive and reproducible model develop..

The Activation Of Lipoprotein Lipase By Apolipoprotein C-Ii

Abnormalities in blood lipid levels are common in our society. Treatment of these conditions adds a heavy burden to national health-care cos..

Enhancing The Cardioprotective Effect Of Diadenosine Tetraphosphate: Designing Inhibitors Against Ap4a Hydrolase

Ischemia describes the condition where blood flow in the blood vessels of the heart is decreased or blocked, preventing delivery of oxygen a..

Peptide Inhibitors Of Amyloid Fibril Formation

36

Projects

Project Types

Research Grant

Internal Research Grant

Research Contracts

Scholarly Works

Displaying the 157 most recent scholarly works by Paul Gooley.

Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

Md Alamgir Hossain, Florence Larrous, Stephen M Rawlinson, Jingyu Zhan, Ashish Sethi, Youssef Ibrahim, Maria Aloi, Kim G Lieu, Yee-Foong Mok, Michael DW Griffin, Naoto Ito, Toyoyuki Ose, Herve Bourhy, Gregory W Moseley, Paul R Gooley

Journal article | 2019 | Cell Reports

To evade immunity, many viruses express interferon antagonists that target STAT transcription factors as a major component of path..

THE STRUCTURE OF THE INTERLEUKIN 11 SIGNALLING COMPLEX

Riley D Metcalfe, Kahenia Aizel, Courtney O Zlatic, Paul M Nguyen, Paul R Gooley, Tracy L Putoczki, Michael DW Griffin

Conference Proceedings | 2019 | PROTEIN SCIENCE

Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Metabolism Deregulation in ME/CFS Cases

Neil R McGregor, Christopher W Armstrong, Donald P Lewis, Paul R Gooley

Journal article | 2019 | Diagnostics

Heteronuclear NMR spectroscopy of proteins encapsulated in cubic phase lipids

Thomas G Meikle, Ashish Sethi, David W Keizer, Jeffrey J Babon, Frances Separovic, Paul R Gooley, Charlotte E Conn, Shenggen Yao

Journal article | 2019 | Journal of Magnetic Resonance

H-1, N-15 and C-13 resonance assignments of the C-terminal domain of the P protein of the Nishigahara strain of rabies virus

Jingyu Zhan, Md Alamgir Hossain, Ashish Sethi, Toyoyuki Ose, Gregory W Moseley, Paul R Gooley

Journal article | 2019 | Biomolecular NMR Assignments

Diazepam is not a direct allosteric modulator of alpha(1)-adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase-4

Lisa M Williams, Xiaoji He, Tasneem M Vaid, Alaa Abdul-Ridha, Alice R Whitehead, Paul R Gooley, Ross AD Bathgate, Spencer J Williams, Daniel J Scott

Journal article | 2019 | Pharmacology Research & Perspectives

Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis

Bradley L Hoare, Shoni Bruell, Ashish Sethi, Paul R Gooley, Michael J Lew, Mohammed A Hossain, Asuka Inoue, Daniel J Scott, Ross AD Bathgate

Journal article | 2019 | iScience

Expression and Purification of a Functional E. coli 13CH3-Methionine-Labeled Thermostable Neurotensin Receptor 1 Variant for Solution NMR Studies.

Fabian Bumbak, Ross AD Bathgate, Daniel J Scott, Paul R Gooley

Journal article | 2019 | Methods in molecular biology (Clifton, N.J.)

Escherichia coli (E. coli) is the most widely used expression host for recombinant proteins due to high expression yields and stra..

Polymorphism in disease-related apolipoprotein C-II amyloid fibrils: a structural model for rod-like fibrils

Courtney O Zlatic, Yu Mao, Nevena Todorova, Yee-Foong Mok, Geoffrey J Howlett, Irene Yarovsky, Paul R Gooley, Michael DW Griffin

Journal article | 2018 | The FEBS Journal

The relaxin receptor as a therapeutic target - perspectives from evolution Cheek for updates and drug targeting

Ross AD Bathgate, Martina Kocan, Daniel J Scott, M Akhter Hossain, Sara V Good, Sergey Yegorov, Jan Bogerd, Paul R Gooley

Journal article | 2018 | Pharmacology & Therapeutics

Optimization and (CH3)-C-13 methionine labeling of a signaling competent neurotensin receptor 1 variant for NMR studies

Fabian Bumbak, Alastair C Keen, Natalie J Gunn, Paul R Gooley, Ross AD Bathgate, Daniel J Scott

Journal article | 2018 | Biochimica et Biophysica Acta (BBA) - Biomembranes

Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length

Estella A Newcombe, Kiersten M Ruff, Ashish Sethi, Angelique R Ormsby, Yasmin M Ramdzan, Archa Fox, Anthony W Purcell, Paul R Gooley, Rohit Pappu, Danny M Hatters

Journal article | 2018 | Journal of Molecular Biology

Determinants of Ligand Subtype-Selectivity at alpha(1A)-Adrenoceptor Revealed Using Saturation Transfer Difference (STD) NMR

Kelvin J Yong, Tasneem M Vaid, Patrick J Shilling, Feng-Jie Wu, Lisa M Williams, Mattia Deluig, Andreas Plueckthun, Ross AD Bathgate, Paul R Gooley, Daniel J Scott

Journal article | 2018 | ACS Chemical Biology

The UBA domain of SnRK1 promotes activation and maintains catalytic activity

Shane Emanuelle, Monika S Doblin, Paul R Gooley, Matthew S Gentry

Journal article | 2018 | Biochemical and Biophysical Research Communications

Unravelling the Carbohydrate-Binding Preferences of the Carbohydrate-Binding Modules of AMP-Activated Protein Kinase

Jesse I Mobbs, Alex Di Paolo, Riley D Metcalfe, Emily Selig, David I Stapleton, Michael DW Griffin, Paul R Gooley

Journal article | 2018 | ChemBioChem

Applications of NMR and ITC for the Study of the Kinetics of Carbohydrate Binding by AMPK beta-Subunit Carbohydrate-Binding Modules

Paul R Gooley, Ann Koay, Jesse I Mobbs

Book Chapter | 2018 | Methods in Molecular Biology

Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin

Shoni Bruell, Ashish Sethi, Nicholas Smith, Daniel J Scott, Mohammed Akhter Hossain, Qing-Ping Wu, Zhan-Yun Guo, Emma J Petrie, Paul R Gooley, Ross AD Bathgate

Journal article | 2017 | Scientific Reports

Characterisation of a cell-free synthesised G-protein coupled receptor

Patrick J Shilling, Fabian Bumbak, Daniel J Scott, Ross AD Bathgate, Paul R Gooley

Journal article | 2017 | Scientific Reports

Intra- and Intersubunit Ion-Pair Interactions Determine the Ability of Apolipoprotein C-II Mutants To Form Hybrid Amyloid Fibrils.

Nevena Todorova, Courtney O Zlatic, Yu Mao, Irene Yarovsky, Geoffrey J Howlett, Paul R Gooley, Michael DW Griffin

Journal article | 2017 | Biochemistry

The apolipoprotein family is structurally defined by amphipathic α-helical regions that interact with lipid surfaces. In the absen..

Intra- and Intersubunit Ion-Pair Interactions Determine the Ability of Apolipoprotein C-II Mutants To Form Hybrid Amyloid Fibrils

Nevena Todorova, Courtney O Zlatic, Yu Mao, Irene Yarovsky, Geoffrey J Howlett, Paul R Gooley, Michael DW Griffin

Journal article | 2017 | BIOCHEMISTRY

The association of fecal microbiota and fecal, blood serum and urine metabolites in myalgic encephalomyelitis/chronic fatigue syndrome

Christopher W Armstrong, Neil R McGregor, Donald P Lewis, Henry L Butt, Paul R Gooley

Journal article | 2017 | Metabolomics

beta-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase

Nada Ali, Naomi Ling, Srinath Krishnamurthy, Jonathan S Oakhill, John W Scott, David I Stapleton, Bruce E Kemp, Ganesh Srinivasan Anand, Paul R Gooley

Journal article | 2016 | Scientific Reports

THE STRUCTURAL BASIS OF LYSSAVIRUS MODULATION OF CYTOKINE SIGNALING

GW Moseley, A Hossain, A Harrison, J Zhan, K Lieu, C Deffrasness, S Rawlinson, T Ose, N Ito, P Gooley

Conference Proceedings | 2016 | CYTOKINE

Solution Conditions Affect the Ability of the K30D Mutation To Prevent Amyloid Fibril Formation by Apolipoprotein C-II: Insights from Experiments and Theoretical Simulations

Yu Mao, Nevena Todorova, Courtney O Zlatic, Paul R Gooley, Michael DW Griffin, Geoffrey J Howlett, Irene Yarovsky

Journal article | 2016 | Biochemistry

When phosphorylated at Thr(148), the beta(2)-subunit of AMP-activated kinase does not associate with glycogen in skeletal muscle

Hongyang Xu, Noni T Frankenberg, Graham D Lamb, Paul R Gooley, David I Stapleton, Robyn M Murphy

Journal article | 2016 | American Journal of Physiology-Cell Physiology

Molecular Insights into the Enigmatic Metabolic Regulator, SnRK1

Shane Emanuelle, Monika S Doblin, David I Stapleton, Antony Bacic, Paul R Gooley

Journal article | 2016 | Trends in Plant Science

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

Ashish Sethi, Shoni Bruell, Nitin Patil, Mohammed Akhter Hossain, Daniel J Scott, Emma J Petrie, Ross AD Bathgate, Paul R Gooley

Journal article | 2016 | Nature Communications

Native Chemical Ligation to Minimize Aspartimide Formation during Chemical Synthesis of Small LDLa Protein

Julien Tailhades, Ashish Sethi, Emma J Petrie, Paul R Gooley, Ross A Bathgate, John D Wade, Mohammed A Hossain

Journal article | 2016 | Chemistry - A European Journal

Widespread pain and altered renal function in ME/CFS patients

Neil R McGregor, Christopher W Armstrong, Donald P Lewis, Henry L Butt, Paul R Gooley

Journal article | 2016 | Fatigue: Biomedicine, Health & Behavior

Regulation of Starch Stores by a Ca2 -Dependent Protein Kinase Is Essential for Viable Cyst Development in Toxoplasma gondii

Alessandro D Uboldi, James M McCoy, Martin Blume, Motti Gerlic, David JP Ferguson, Laura F Dagley, Cherie T Beahan, David I Stapleton, Paul R Gooley, Antony Bacic, Seth L Masters, Andrew I Webb, Malcolm J McConville, Christopher J Tonkin

Journal article | 2015 | Cell Host & Microbe

Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients

Christopher W Armstrong, Neil R McGregor, Donald P Lewis, Henry L Butt, Paul R Gooley

Journal article | 2015 | Metabolomics

In a class of their own-RXFP1 and RXFP2 are unique members of the LGR family

Emma J Petrie, Samantha Lagaida, Ashish Sethi, Ross AD Bathgate, Paul R Gooley

Journal article | 2015 | Frontiers in Endocrinology

Hydrogen/Deuterium Exchange and Molecular Dynamics Analysis of Amyloid Fibrils Formed by a D69K Charge-Pair Mutant of Human Apolipoprotein C-II

Yu Mao, Courtney O Zlatic, Michael DW Griffin, Geoffrey J Howlett, Nevena Todorova, Irene Yarovsky, Paul R Gooley

Journal article | 2015 | Biochemistry

Determinants of oligosaccharide specificity of the carbohydrate-binding modules of AMP-activated protein kinase

Jesse I Mobbs, Ann Koay, Alex Di Paolo, Michael Bieri, Emma J Petrie, Michael A Gorman, Larissa Doughty, Michael W Parker, David I Stapleton, Michael DW Griffin, Paul R Gooley

Journal article | 2015 | Biochemical Journal

Structure of amylase-binding protein A of Streptococcus gordonii: A potential receptor for human salivary -amylase enzyme

Ashish Sethi, Biswaranjan Mohanty, Narayanan Ramasubbu, Paul R Gooley

Journal article | 2015 | Protein Science

The Recruitment of AMP-activated Protein Kinase to Glycogen Is Regulated by Autophosphorylation

Yvonne Oligschlaeger, Marie Miglianico, Dipanjan Chanda, Roland Scholz, Ramon F Thali, Roland Tuerk, David I Stapleton, Paul R Gooley, Dietbert Neumann

Journal article | 2015 | Journal of Biological Chemistry

SnRK1 from Arabidopsis thaliana is an atypical AMPK

Shane Emanuelle, Mohammed Iqbal Hossain, Isabel E Moller, Henriette L Pedersen, Allison ML van de Meene, Monika S Doblin, Ann Koay, Jonathan S Oakhill, John W Scott, William GT Willats, Bruce E Kemp, Antony Bacic, Paul R Gooley, David I Stapleton

Journal article | 2015 | The Plant Journal

Physical characterisation of high amylose maize starch and acylated high amylose maize starches

Ya-Mei Lim, Pamela Hoobin, DanYang Ying, Iko Burgar, Paul R Gooley, Mary Ann Augustin

Journal article | 2015 | Carbohydrate Polymers

Charge and Charge-Pair Mutations Alter the Rate of Assembly and Structural Properties of Apolipoprotein C-II Amyloid Fibrils

Yu Mao, Chai Lean Teoh, Shuo Yang, Courtney O Zlatic, Zachary K Rosenes, Paul R Gooley, Geoffrey J Howlett, Michael DW Griffin

Journal article | 2015 | Biochemistry

Investigation of Interactions at the Extracellular Loops of the Relaxin Family Peptide Receptor 1 (RXFP1)

Natalie A Diepenhorst, Emma J Petrie, Catherine Z Chen, Amy Wang, Mohammed Akhter Hossain, Ross AD Bathgate, Paul R Gooley

Journal article | 2014 | Journal of Biological Chemistry

H-1-NMR analysis of the human urinary metabolome in response to an 18-month multi-component exercise program and calcium-vitamin-D-3 supplementation in older men

John R Sheedy, Paul R Gooley, Amsha Nahid, Dedreia L Tull, Malcolm J McConville, Sonja Kukuljan, Caryl A Nowson, Robin M Daly, Peter R Ebeling

Journal article | 2014 | Applied Physiology, Nutrition and Metabolism

Hydrodynamic radii of solubilized high amylose native and modified starches by pulsed field gradient NMR diffusion measurements

Ya-Mei Lim, Shenggen Yao, Sally L Gras, Chris McSweeney, Trevor Lockett, Mary Ann Augustin, Paul R Gooley

Journal article | 2014 | Food Hydrocolloids

Mapping Key Regions of the RXFP2 Low-Density Lipoprotein Class-A Module That Are Involved in Signal Activation

Roy CK Kong, Ross AD Bathgate, Shoni Bruell, John D Wade, Paul R Gooley, Emma J Petrie

Journal article | 2014 | Biochemistry

The Role of Select Subtype Polymorphisms on HIV-1 Protease Conformational Sampling and Dynamics

Xi Huang, Manuel D Britto, Jamie L Kear-Scott, Christopher D Boone, James R Rocca, Carlos Simmerling, Robert Mckenna, Michael Bieri, Paul R Gooley, Ben M Dunn, Gail E Fanucci

Journal article | 2014 | Journal of Biological Chemistry

Esterification of high amylose starch with short chain fatty acids modulates degradation by Bifidobacterium spp.

Ya-Mei Lim, Mary B Barnes, Sally L Gras, Chris McSweeney, Trevor Lockett, Mary Ann Augustin, Paul R Gooley

Journal article | 2014 | Journal of Functional Foods

Metabolism in Chronic Fatigue Syndrome

Christopher W Armstrong, Neil R McGregor, Henry L Butt, Paul R Gooley

Book Chapter | 2014 | Advances in Clinical Chemistry

The Relaxin Receptor (RXFP1) Utilizes Hydrophobic Moieties on a Signaling Surface of Its N-terminal Low Density Lipoprotein Class A Module to Mediate Receptor Activation

Roy CK Kong, Emma J Petrie, Biswaranjan Mohanty, Jason Ling, Jeremy CY Lee, Paul R Gooley, Ross AD Bathgate

Journal article | 2013 | Journal of Biological Chemistry

Membrane targeting of the small myristoylated protein 2 (SMP-2) in Leishmania major

Joanne Heng, Eleanor C Saunders, Paul R Gooley, Malcolm J McConville, Thomas Naderer, Dedreia Tull

Journal article | 2013 | Molecular and Biochemical Parasitology

Identification and characterization of bi-thiazole-2,2 '-diamines as kinase inhibitory scaffolds

Kevin RW Ngoei, Dominic CH Ng, Paul R Gooley, David P Fairlie, Martini Stoermer, Marie A Bogoyevitch

Journal article | 2013 | Biochimica et Biophysica Acta-Proteins and Proteomics

Characterization of a microtubule-associated protein, doublecortin (DCX), as a substrate of c-Jun N-terminal Kinases (JNKs)

Kevin Ngoei, Paul R Gooley, Michael W Parker, Marie A Bogoyevitch

Conference Proceedings | 2013 | FASEB JOURNAL

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3.

Ross AD Bathgate, Maria HY Oh, WJ Jason Ling, Quentin Kaas, M Akhter Hossain, Paul R Gooley, K Johan Rosengren

Journal article | 2013 | Frontiers in Endocrinology

Relaxin-3 is a highly conserved neuropeptide in vertebrate species and binds to the Class A G protein-coupled receptor (GPCR) RXFP..

Development of a scaffold displaying exoloops of RXFP1.

Natalie A Diepenhorst, Paul R Gooley, Martin J Stone, Ross AD Bathgate

Journal article | 2013 | Italian Journal of Anatomy and Embryology

Relaxin family peptide receptor 1 (RXFP1), the cognate receptor for relaxin, is a G-protein coupled receptor (GPCR) possessing a u..

Cell-free protein synthesis as a tool to study RXFP3-relaxin-3 protein interactions.

Patrick J Shilling, Ross AD Bathgate, Paul R Gooley

Journal article | 2013 | Italian Journal of Anatomy and Embryology

With the discovery of the relaxin family peptide receptors there is interest in obtaining a clearer understanding of the structure..

Chimeric RXFP1 and RXFP2 Receptors Highlight the Similar Mechanism of Activation Utilizing Their N-Terminal Low-Density Lipoprotein Class A Modules.

Shoni Bruell, Roy CK Kong, Emma J Petrie, Brad Hoare, John D Wade, Daniel J Scott, Paul R Gooley, Ross AD Bathgate

Journal article | 2013 | Frontiers in Endocrinology

Relaxin family peptide (RXFP) receptors 1 and 2 are unique G-protein coupled receptors in that they contain an N-terminal low-dens..

Recombinant RXFP1-LDL-A module does not form dimers.

Emma J Petrie, Matthew A Periguini, Ross AD Bathgate, Paul R Gooley

Journal article | 2013 | Italian Journal of Anatomy and Embryology

The Relaxin receptor, RXFP1, is a complex G-protein coupled receptor (GPCR). It has a rhodopsin-like 7 transmembrane helix region ..

Single fiber analyses of glycogen-related proteins reveal their differential association with glycogen in rat skeletal muscle

Robyn M Murphy, Hongyang Xu, Heidy Latchman, Noni T Larkins, Paul R Gooley, David I Stapleton

Journal article | 2012 | American Journal of Physiology - Cell Physiology

NMR metabolic profiling of serum identifies amino acid disturbances in chronic fatigue syndrome

Christopher W Armstrong, Neil R McGregor, John R Sheedy, Ian Buttfield, Henry L Butt, Paul R Gooley

Journal article | 2012 | Clinica Chimica Acta

A Cyclic Peptide Inhibitor of ApoC-II Peptide Fibril Formation: Mechanistic Insight from NMR and Molecular Dynamics Analysis

Michael DW Griffin, Levi Yeung, Andrew Hung, Nevena Todorova, Yee-Foong Mok, John A Karas, Paul R Gooley, Irene Yarovsky, Geoffrey J Howlett

Journal article | 2012 | Journal of Molecular Biology

Acylation-dependent and-independent membrane targeting and distinct functions of small myristoylated proteins (SMPs) in Leishmania major

Dedreia Tull, Joanne Heng, Paul R Gooley, Thomas Naderer, Malcolm J McConville

Journal article | 2012 | International Journal for Parasitology

AMP-Activated Protein Kinase beta-Subunit Requires Internal Motion for Optimal Carbohydrate Binding

Michael Bieri, Jesse I Mobbs, Ann Koay, Gavin Louey, Yee-Foong Mok, Danny M Hatters, Jong-Tae Park, Kwan-Hwa Park, Dietbert Neumann, David Stapleton, Paul R Gooley

Journal article | 2012 | Biophysical Journal

A Dynamic Pharmacophore Drives the Interaction between Psalmotoxin-1 and the Putative Drug Target Acid-Sensing Ion Channel 1a

Natalie J Saez, Mehdi Mobli, Michael Bieri, Irene R Chassagnon, Alpeshkumar K Malde, Roland Gamsjaeger, Alan E Mark, Paul R Gooley, Lachlan D Rash, Glenn F King

Journal article | 2011 | Molecular Pharmacology

Automated NMR relaxation dispersion data analysis using NESSY

Michael Bieri, Paul R Gooley

Journal article | 2011 | BMC Bioinformatics

relaxGUI: a new software for fast and simple NMR relaxation data analysis and calculation of ps-ns and mu s motion of proteins

Michael Bieri, Edward J d'Auvergne, Paul R Gooley

Journal article | 2011 | Journal of Biomolecular NMR

A novel protein engineering approach for investigating GPCR/ligand interactions

Natalie Anne Witteveen, Paul R Gooley, Martin J Stone, Ross AD Bathgate

Conference Proceedings | 2011 | FASEB JOURNAL

Macromolecular NMR spectroscopy for the non-spectroscopist: beyond macromolecular solution structure determination

Michael Bieri, Ann H Kwan, Mehdi Mobli, Glenn F King, Joel P Mackay, Paul R Gooley

Journal article | 2011 | FEBS Journal

Macromolecular NMR spectroscopy for the non-spectroscopist

Ann H Kwan, Mehdi Mobli, Paul R Gooley, Glenn F King, Joel P Mackay

Journal article | 2011 | FEBS Journal

A Structural Model for Apolipoprotein C-II Amyloid Fibrils: Experimental Characterization and Molecular Dynamics Simulations

Chai Lean Teoh, Chi LL Pham, Nevena Todorova, Andrew Hung, Craig N Lincoln, Emma Lees, Yuen Han Lam, Katrina J Binger, Neil H Thomson, Sheena E Radford, Trevor A Smith, Shirley A Mueller, Andreas Engel, Michael DW Griffin, Irene Yarovsky, Paul R Gooley, Geoffrey J Howlett

Journal article | 2011 | Journal of Molecular Biology

Recognition of Mitochondrial Targeting Sequences by the Import Receptors Tom20 and Tom22

Kieran A Rimmer, Jung Hock Foo, Alicia Ng, Emma J Petrie, Patrick J Shilling, Andrew J Perry, Haydyn DT Mertens, Trevor Lithgow, Terrence D Mulhern, Paul R Gooley

Journal article | 2011 | Journal of Molecular Biology

AMPK beta subunits display isoform specific affinities for carbohydrates

Ann Koay, Ben Woodcroft, Emma J Petrie, Helen Yue, Shane Emanuelle, Michael Bieri, Michael F Bailey, Mark Hargreaves, Jong-Tae Park, Kwan-Hwa Park, Stuart Ralph, Dietbert Neumann, David Stapleton, Paul R Gooley

Journal article | 2010 | FEBS Letters

Recognition and Detoxification of the Insecticide DDT by Drosophila melanogaster Glutathione S-Transferase D1

Wai Yee Low, Susanne C Feil, Hooi Ling Ng, Michael A Gorman, Craig J Morton, James Pyke, Malcolm J McConville, Michael Bieri, Yee-Foong Mok, Charles Robin, Paul R Gooley, Michael W Parker, Philip Batterham

Journal article | 2010 | Journal of Molecular Biology

Membrane receptors: Structure and function of the relaxin family peptide receptors

Roy CK Kong, Patrick J Shilling, Derek K Lobb, Paul R Gooley, Ross AD Bathgate

Journal article | 2010 | Molecular and Cellular Endocrinology

A sample preparation protocol for H-1 nuclear magnetic resonance studies of water-soluble metabolites in blood and urine

John R Sheedy, Peter R Ebeling, Paul R Gooley, Malcolm J McConville

Journal article | 2010 | Analytical Biochemistry

Membrane protein SMP-1 is required for normal flagellum function in Leishmania

Dedreia Tull, Thomas Naderer, Timothy Spurck, Haydyn DT Mertens, Joanne Heng, Geoffrey I McFadden, Paul R Gooley, Malcolm J McConville

Journal article | 2010 | Journal of Cell Science

Discovery of Inhibitors of Lupin Diadenosine 5 ',5 '''-P-1,P-4-Tetraphosphate Hydrolase by Virtual Screening

Kim M Branson, Haydyn DT Mertens, James D Swarbrick, Jamie I Fletcher, Lukasz Kedzierski, Kenwyn R Gayler, Paul R Gooley, Brian J Smith

Journal article | 2009 | Biochemistry

Increased D-Lactic Acid Intestinal Bacteria in Patients with Chronic Fatigue Syndrome

John R Sheedy, Richard EH Wettenhall, Denis Scanlon, Paul R Gooley, Donald P Lewis, Neil Mcgregor, David I Stapleton, Henry L Butt, Kenny L De Meirleir

Journal article | 2009 | In Vivo: international journal of experimental and clinical pathophysiology and drug research

A combined technological metabolomic strategy for the identification of metabolites in human urine

JR Sheedy, PR Ebeling, REH Wettenhall, PR Gooley, M McConville

Conference Proceedings | 2009 | Bone

Structure and Function of Human Apolipoprotein

PF James, BW Atcliffe, PR Gooley, T Mulhern, GJ Howlett, RA O'Hair, MAP Perugini

Journal article | 2009 | Current Topics in Biochemical Research

Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase beta 1-Containing Complexes

John W Scott, Bryce JW van Denderen, Sebastian B Jorgensen, Jane E Honeyman, Gregory R Steinberg, Jonathan S Oakhill, Tristan J Iseli, Ann Koay, Paul R Gooley, David Stapleton, Bruce E Kemp

Journal article | 2008 | Chemistry & Biology

Structure, topology and function of the translocase of the outer membrane of mitochondria

Andrew J Perry, Kieran A Rimmer, Haydyn DT Mertens, Ross F Waller, Terrence D Mulhern, Trevor Lithgow, Paul R Gooley

Journal article | 2008 | Plant Physiology and Biochemistry

The transmembrane segment of Tom20 is recognized by Mim1 for docking to the mitochondrial TOM complex

Joanne M Hulett, Franziska Lueder, Nickie C Chan, Andrew J Perry, Peter Wolynec, Vladimir A Likic, Paul R Gooley, Trevor Lithgow

Journal article | 2008 | Journal of Molecular Biology

Optimisation of NMR dynamic models II. A new methodology for the dual optimisation of the model-free parameters and the Brownian rotational diffusion tensor

Edward J d'Auvergne, Paul R Gooley

Journal article | 2008 | Journal of Biomolecular NMR

Optimisation of NMR dynamic models I. Minimisation algorithms and their performance within the model-free and Brownian rotational diffusion spaces

Edward J d'Auvergne, Paul R Gooley

Journal article | 2008 | Journal of Biomolecular NMR

A high-resolution solution structure of a trypanosomatid FYVE domain

Haydyn DT Mertens, Judy M Callaghan, James D Swarbrick, Malcolm J Mcconville, Paul R Gooley

Journal article | 2007 | Protein Science

Oligosaccharide recognition and binding to the carbohydrate binding module of AMP-activated protein kinase

Ann Koay, Kieran A Rimmer, Haydyn DT Mertens, Paul R Gooley, David Stapleton

Journal article | 2007 | FEBS Letters

Probing the flexibility of the DsbA oxidoreductase from Vibrio cholerae - a N-15-H-1 heteronuclear NMR relaxation analysis of oxidized and reduced forms of DsbA

James Horne, Edward J d'Auvergne, Murray Coles, Tony Velkov, Yanni Chin, William N Charman, Richard Prankerd, Paul R Gooley, Martin J Scanlon

Journal article | 2007 | Journal of Molecular Biology

High-level expression of a soluble and functional fibronectin type II domain from MMP-2 in the Escherichia coli cytoplasm for solution NMR studies

Alys A Peisley, Paul R Gooley

Journal article | 2007 | Protein Expression and Purification

A structural core within apolipoprotein C-II amyloid fibrils identified using hydrogen exchange and proteolysis

Leanne M Wilson, Yee-Foong Mok, Katrina J Binger, Michael DW Griffin, Haydyn DT Mertens, Feng Lin, John D Wade, Paul R Gooley, Geoffrey J Howlett

Journal article | 2007 | Journal of Molecular Biology

The NMR solution structure of the relaxin (RXFP1) receptor lipoprotein receptor class A module and identification of key residues in the N-terminal region of the module that mediate receptor activation

Emma J Hopkins, Sharon Layfield, Tania Ferraro, Ross AD Bathgate, Paul R Gooley

Journal article | 2007 | Journal of Biological Chemistry

Set theory formulation of the model-free problem and the diffusion seeded model-free paradigm

Edward J d'Auvergne, Paul R Gooley

Journal article | 2007 | Molecular BioSystems

Model-free model elimination: A new step in the model-free dynamic analysis of NMR relaxation data

Edward J d'Auvergne, Paul R Gooley

Journal article | 2006 | Journal of Biomolecular NMR

Convergent evolution of receptors for protein import into mitochondria

AJ Perry, JM Hulett, VA Likic, T Lithgow, PR Gooley

Journal article | 2006 | Current Biology

H-1, C-13 and N-15 resonance assignments of SMP-1: A small myristoylated protein from Leishmania major

Paul R Gooley, Haydyn DT Mertens, Dedreia Tull, Malcolm J McConville

Journal article | 2006 | Journal of Biomolecular NMR

A statistical approach to the interpretation of molecular dynamics simulations of calmodulin equilibrium dynamics

VA Likic, PR Gooley, TP Speed, EE Strehler

Journal article | 2005 | Protein Science

H-1, C-13 and N-15 resonance assignments of the cytosolic domain of Tom20 from Arabidopsis thaliana

AJ Perry, JM Hulett, T Lithgow, PR Gooley

Journal article | 2005 | Journal of Biomolecular NMR

Validating the use of database potentials in protein structure determination by NMR

HDT Mertens, PR Gooley

Journal article | 2005 | FEBS Letters

Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20

VA Likic, A Perry, J Hulett, M Derby, A Traven, RF Waller, PJ Keeling, CM Koehler, SP Curran, PR Gooley, T Lithgow

Journal article | 2005 | Journal of Molecular Biology

Structure and substrate-binding mechanism of human Ap(4)A hydrolase

JD Swarbrick, S Buyya, D Gunawardana, KR Gayler, AG McLennan, PR Gooley

Journal article | 2005 | Journal of Biological Chemistry

Letter to the Editor: H-1, C-13, and N-15 resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP

JD Swarbrick, S Buyya, D Gunawardana, JI Fletcher, K Branson, B Smith, S Pepe, A McLennan, KR Gayler, PR Gooley

Journal article | 2005 | Journal of Biomolecular NMR

The human LGR7 low-density lipoprotein class A module requires calcium for structure

EJ Hopkins, RA Bathgate, PR Gooley

Journal article | 2005 | Annals of The New York Academy of Sciences

The structure and interactions of human apolipoprotein C-II in dodecyl phosphocholine

CA MacRaild, GJ Howlett, PR Gooley

Journal article | 2004 | Biochemistry

Multiple heparin binding domains of respiratory syncytial virus G mediate binding to mammalian cells

B Shields, J Mills, R Ghildyal, P Gooley, J Meanger

Journal article | 2003 | Archives of Virology

Dynamics of Ca2 -saturated calmodulin D129N mutant studied by multiple molecular dynamics simulations

VA Likic, EE Strehler, PR Gooley

Journal article | 2003 | Protein Science

The use of model selection in the model-free analysis of protein dynamics

EJ d'Auvergne, PR Gooley

Journal article | 2003 | Journal of Biomolecular NMR

Human vascular endothelial growth factor B: Characterization of recombinant isoforms and generation of neutralizing monoclonal antibodies

PD Scotney, A MacKenzie, P Maccarone, LJ Fabri, SDB Scrofani, PR Gooley, AD Nash

Journal article | 2002 | Clinical and Experimental Pharmacology and Physiology

Mutagenesis studies on the NUDT hydrolase Ap4A hydrolase

D Gunawardana, S Buyya, A Peisley, J Fletcher, D Maksel, AG McClennan, PR Gooley, KR Gayler

Conference Proceedings | 2002 | DRUG DEVELOPMENT RESEARCH

Structural determinants of the substrate specificity of diadenosine tetraphosphate hydrolase.

PR Gooley, JI Fletcher, JD Swarbrick, EJ d'Auvergne, D Maksel, GM Blackburn, KR Gayler

Conference Proceedings | 2002 | DRUG DEVELOPMENT RESEARCH

Structural characterization of the N-terminal autoregulatory sequence of phenylalanine hydroxylase

J Horne, IG Jennings, T Teh, PR Gooley, B Kobe

Journal article | 2002 | Protein Science

Letter to the Editor: Backbone resonance assignment of the H-2, C-13, N-15 labelled 32kDa central domain of Escherichia coli TyrR

JD Swarbrick, T Bashtannyk, M Dixon, RN Pau, BE Davidson, PR Gooley

Journal article | 2002 | Journal of Biomolecular NMR

The structure of Ap(4)A hydrolase complexed with ATP-MgFx reveals the basis of substrate binding

JI Fletcher, JD Swarbrick, D Maksel, KR Gayler, PR Gooley

Journal article | 2002 | Structure

Characterization of active-site residues in diadenosine tetraphosphate hydrolase from Lupinus angustifolius

D Maksel, PR Gooley, JD Swarbrick, A Guranowski, C Gange, GM Blackburn, KR Gayler

Journal article | 2001 | Biochemical Journal

NMR structure of human apolipoprotein C-II in the presence of sodium dodecyl sulfate

CA MacRaild, DM Hatters, GJ Howlett, PR Gooley

Journal article | 2001 | Biochemistry

The interaction of human apolipoprotein C-I with sub-micellar phospholipid

BW Atcliffe, CA MacRaild, PR Gooley, GJ Howlett

Journal article | 2001 | European Journal of Biochemistry

Crystallization and preliminary X-ray diffraction studies of FHA domains of Dun1 and Rad53 protein kinases

H Blanchard, MRM Fontes, A Hammet, BL Pike, T Teh, T Gleichmann, PR Gooley, B Kobe, J Heierhorst

Journal article | 2001 | Acta Crystallographica Section D - Biological Crystallography

The three-dimensional structure of the Nudix enzyme diadenosine tetraphosphate hydrolase from Lupinus angustifolius L

JD Swarbrick, T Bashtannyk, D Maksel, XR Zhang, GM Blackburn, KR Gayler, PR Gooley

Journal article | 2000 | Journal of Molecular Biology

Redox-related conformational changes in Rhodobacter capsulatus cytochrome c(2)

DZ Zhao, HM Hutton, PR Gooley, NE MacKenzie, MA Cusanovich

Journal article | 2000 | Protein Science

Letter to the Editor: H-1, C-13 and N-15 backbone assignment and secondary structure of the 19 kDa diadenosine 5 ', 5 '''-P-1, P-4-tetraphosphate hydrolase from Lupinus angustifolius L.

JD Swarbrick, T Bashtannyk, D Maksel, RN Pau, KR Gayler, PR Gooley

Journal article | 2000 | Journal of Biomolecular NMR

Enhanced protein fold recognition using secondary structure information from NMR

DJ Ayers, PR Gooley, A Widmer-Cooper, AE Torda

Journal article | 1999 | Protein Science

The NMR solution structure and characterization of pH dependent chemical shifts of the beta-elicitin, cryptogein

PR Gooley, MA Keniry, RA Dimitrov, DE Marsh, DW Keizer, KR Gayler, BR Grant

Journal article | 1998 | Journal of Biomolecular NMR

The solution structure of beta-cryptogein by NMR spectroscopy.

PR Gooley, DW Keizer, KR Gayler, BR Grant

Conference Proceedings | 1997 | PLANT PHYSIOLOGY

The substitution of proline 35 by alanine in Rhodobacter capsulatus cytochrome c(2) affects the overall protein stability but not the alkaline transition

MS Caffrey, PR Gooley, DZ Zhao, TE Meyer, MA Cusanovich, NE MacKenzie

Journal article | 1997 | Protein Engineering Design and Selection

Comparison of the structure of human recombinant short form stromelysin by multidimensional heteronuclear NMR and X-ray crystallography

PR Gooley, JF OConnell, AI Marcy, GC Cuca, MG Axel, CG Caldwell, WK Hagmann, JW Becker

Journal article | 1996 | Journal of Biomolecular NMR

THE 3-DIMENSIONAL STRUCTURE OF THE INHIBITED CATALYTIC DOMAIN OF STROMELYSIN-1

PR GOOLEY, JF OCONNELL, BA JOHNSON, AI MARCY, SP SALOWE, GC CUCA

Conference Proceedings | 1995 | JOURNAL OF CELLULAR BIOCHEMISTRY

THE NMR STRUCTURE OF THE INHIBITED CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1

PR GOOLEY, JF OCONNELL, AI MARCY, GC CUCA, SP SALOWE, BL BUSH, JD HERMES, CK ESSER, WK HAGMANN, JP SPRINGER, BA JOHNSON

Journal article | 1994 | Nature Structural & Molecular Biology

SECONDARY STRUCTURE AND ZINC LIGATION OF HUMAN RECOMBINANT SHORT-FORM STROMELYSIN BY MULTIDIMENSIONAL HETERONUCLEAR NMR

PR GOOLEY, BA JOHNSON, AI MARCY, GC CUCA, SP SALOWE, WK HAGMANN, CK ESSER, JP SPRINGER

Journal article | 1993 | Biochemistry

STRUCTURE AND ZINC LIGATION OF THE CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1

PR GOOLEY, BA JOHNSON, AI MARCY, SP SALOWE, GC CUCA

Conference Proceedings | 1993 | ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

TOWARDS THE STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1

PR GOOLEY, BA JOHNSON, AI MARCY, SP SALOWE, GC CUCA

Conference Proceedings | 1993 | JOURNAL OF CELLULAR BIOCHEMISTRY

BIOLOGICALLY-ACTIVE ARG-GLY-ASP OLIGOPEPTIDES ASSUME A TYPE-II BETA-TURN IN SOLUTION

WC JOHNSON, TG PAGANO, CT BASSON, JA MADRI, P GOOLEY, IM ARMITAGE

Journal article | 1993 | Biochemistry

IDENTIFICATION AND COMPARISON OF THE URINARY METABOLITES OF [1,2,3-C-13(3)] ACRYLIC-ACID AND [1,2,3-C-13(3)]PROPIONIC ACID IN THE RAT BY HOMONUCLEAR C-13 NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY

SM WINTER, GL WEBER, PR GOOLEY, NE MACKENZIE, IG SIPES

Journal article | 1992 | Drug Metabolism and Disposition

MUTATIONS PRO-]ALA-35 AND TYR-]PHE-75 OF RHODOBACTER-CAPSULATUS FERROCYTOCHROME-C2 AFFECT PROTEIN BACKBONE DYNAMICS - MEASUREMENTS OF INDIVIDUAL AMIDE PROTON-EXCHANGE RATE CONSTANTS BY H-1-N-15 HMQC SPECTROSCOPY

PR GOOLEY, MS CAFFREY, MA CUSANOVICH, NE MACKENZIE

Journal article | 1992 | Biochemistry

SOLVING SOLUTION STRUCTURES OF PHYSIOLOGICALLY RELEVANT PROTEINS BY NMR-SPECTROSCOPY

NE MACKENZIE, PR GOOLEY, LA HARDAWAY

Journal article | 1992 | Annual Review of Physiology

Comparison of amide proton exchange in reduced and oxidized Rhodobacter capsulatus cytochrome c2: a 1H-15N NMR study.

PR Gooley, D Zhao, NE MacKenzie

Journal article | 1991 | Journal of Biomolecular Nmr

The hydrogen-deuterium exchange rates of the reduced and oxidized forms of Rhodobacter capsulatus cytochrome c2 were studied by 1H..

COMPUTER-SIMULATION OF THE BINDING OF NAPHTHYRIDINOMYCIN AND CYANOCYCLINE-A TO DNA

GC HILL, TP WUNZ, NE MACKENZIE, PR GOOLEY, WA REMERS

Journal article | 1991 | Journal of Medicinal Chemistry

CONFORMATION OF MEALA6-CYCLOSPORINE-A BY NMR - RELATIONSHIP OF SIDE-CHAIN ORIENTATION OF THE MEBMT-1, MELEU-9, AND MELEU-10 RESIDUES TO IMMUNOSUPPRESSIVE ACTIVITY

PR GOOLEY, PL DURETTE, J BOGER, IM ARMITAGE

Journal article | 1991 | International Journal of Peptide and Protein Research

A SPECTROSCOPIC ANALYSIS OF THE PRO35-]ALA MUTANT OF RHODOBACTER-CAPSULATUS CYTOCHROME-C2 - THE STRICTLY CONSERVED PRO35 IS NOT STRUCTURALLY ESSENTIAL

PR GOOLEY, MS CAFFREY, MA CUSANOVICH, NE MACKENZIE

Journal article | 1991 | European Journal of Biochemistry

ASSIGNMENT OF THE H-1 AND N-15 NMR-SPECTRA OF RHODOBACTER-CAPSULATUS FERROCYTOCHROME-C2

PR GOOLEY, MS CAFFREY, MA CUSANOVICH, NE MACKENZIE

Journal article | 1990 | Biochemistry

PRO-]ALA-35 CYTOCHROME-C2 SHOWS DYNAMIC NOT STRUCTURAL DIFFERENCES

PR GOOLEY, NE MACKENZIE

Conference Proceedings | 1990 | BIOPHYSICAL JOURNAL

Pro----Ala-35 Rhodobacter capsulatus cytochrome c2 shows dynamic not structural differences. A 1H and 15N NMR study.

PR Gooley, NE MacKenzie

Journal article | 1990 | FEBS Letters

Comparative analysis of nuclear Overhauser effects show that the time average conformation of the wild-type and mutant Pro----Ala-..

PRO-]ALA-35 RHODOBACTER-CAPSULATUS CYTOCHROME-C2 SHOWS DYNAMIC NOT STRUCTURAL DIFFERENCES - A H-1 AND N-15 NMR-STUDY

PR GOOLEY, NE MACKENZIE

Journal article | 1990 | FEBS Letters

COMPARISON OF GLYCOLYSIS AND GLUTAMINOLYSIS IN ONCHOCERCA-VOLVULUS AND BRUGIA-PAHANGI BY C-13 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY

NE MACKENZIE, EA VANDEWAA, PR GOOLEY, JF WILLIAMS, JL BENNETT, SM BJORGE, TA BAILLE, TG GEARY

Journal article | 1989 | Parasitology

EFFECTS OF PH AND TEMPERATURE ON CARDIOACTIVE POLYPEPTIDES FROM SEA-ANEMONES - A H-1-NMR STUDY

PR GOOLEY, JW BLUNT, L BERESS, RS NORTON

Journal article | 1988 | Biopolymers

LOCATION OF AN ALPHA-HELIX IN FRAGMENT-96-133 FROM BOVINE SOMATOTROPIN BY H-1-NMR SPECTROSCOPY

PR GOOLEY, NE MACKENZIE

Journal article | 1988 | Biochemistry

DETERMINATION OF LOCAL CONFORMATIONAL STABILITY IN FRAGMENT 96-133 OF BOVINE GROWTH-HORMONE BY HIGH-RESOLUTION H-1-NMR SPECTROSCOPY

PR GOOLEY, SM PLAISTED, DN BREMS, NE MACKENZIE

Journal article | 1988 | Biochemistry

CHARACTERIZATION OF PARASITE METABOLISM BY C-13 NMR-SPECTROSCOPY

NE MACKENZIE, EA VANDEWAA, PR GOOLEY, JL BENNET, JF WILLIAMS, DE MCCLOSKEY, AI SCOTT, SM BJORGE, TA BAILLIE, TG GEARY

Conference Proceedings | 1988 | APPLIED RADIATION AND ISOTOPES

APPLICATIONS OF NMR-SPECTROSCOPY TO BIOLOGICAL-SYSTEMS

NE MACKENZIE, PR GOOLEY

Journal article | 1988 | Medicinal Research Reviews

PREFERRED CONFORMATIONAL STATE OF THE N-TERMINUS SECTION OF A BOVINE GROWTH-HORMONE FRAGMENT (RESIDUES 96-133) IN WATER IS AN OMEGA-LOOP

PR GOOLEY, SA CARTER, PE FAGERNESS, NE MACKENZIE

Journal article | 1988 | Proteins: Structure, Function, and Genetics

APPLICATION OF DROPLET COUNTERCURRENT CHROMATOGRAPHY TO THE ANALYSIS OF CONJUGATED FORMS OF TERPENOIDS, PHENOLS, AND OTHER CONSTITUENTS OF GRAPE JUICE

CR STRAUSS, PR GOOLEY, B WILSON, PJ WILLIAMS

Journal article | 1987 | Journal of Agricultural and Food Chemistry

SECONDARY STRUCTURE IN SEA-ANEMONE POLYPEPTIDES - A PROTON NUCLEAR-MAGNETIC-RESONANCE STUDY

PR GOOLEY, RS NORTON

Journal article | 1986 | Biochemistry

SPECIFIC ASSIGNMENT OF RESONANCES IN THE H-1-NMR SPECTRUM OF THE POLYPEPTIDE TOXIN-I FROM ANEMONIA-SULCATA

PR GOOLEY, RS NORTON

Journal article | 1986 | Biopolymers

ASSIGNMENT OF AROMATIC RESONANCES IN THE H-1 NUCLEAR-MAGNETIC-RESONANCE SPECTRA OF CARDIOACTIVE POLYPEPTIDES FROM SEA-ANEMONES

PR GOOLEY, JW BLUNT, L BERESS, TR NORTON, RS NORTON

Journal article | 1986 | Journal of Biological Chemistry

ROLE OF MONOTERPENES IN GRAPE AND WINE FLAVOR

CR STRAUSS, B WILSON, PR GOOLEY, PJ WILLIAMS

Journal article | 1986 | ACS SYMPOSIUM SERIES

SPECIFIC ASSIGNMENT OF RESONANCES IN THE H-1 NUCLEAR-MAGNETIC-RESONANCE SPECTRUM OF THE POLYPEPTIDE CARDIAC STIMULANT ANTHOPLEURIN-A

PR GOOLEY, RS NORTON

Journal article | 1985 | European Journal of Biochemistry

STRUCTURE OF CARDIOACTIVE POLYPEPTIDES FROM SEA-ANEMONES - A HIGH-RESOLUTION NMR-STUDY

PR GOOLEY, RS NORTON

Conference Proceedings | 1985 | TOXICON

CONFORMATIONAL HETEROGENEITY IN POLYPEPTIDE CARDIAC STIMULANTS FROM SEA-ANEMONES

PR GOOLEY, JW BLUNT, RS NORTON

Journal article | 1984 | FEBS Letters

H-1-NMR STUDIES OF CARDIOSTIMULANT POLYPEPTIDES FROM SEA-ANEMONES

PR GOOLEY, JW BLUNT, RS NORTON

Conference Proceedings | 1984 | PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY

H-1 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPIC STUDY OF THE POLYPEPTIDE TOXIN-I FROM ANEMONIA-SULCATA

PR GOOLEY, L BERESS, RS NORTON

Journal article | 1984 | Biochemistry

HIGH-RESOLUTION H-1-NMR STUDIES OF CARDIAC STIMULANT POLYPEPTIDES

PR GOOLEY, RS NORTON

Conference Proceedings | 1983 | PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY

α1A-adrenoceptor inverse agonists and agonists modulate receptor signalling through a conformational selection mechanism

Feng-Jie Wu, Lisa M Williams, Alaa Abdul-Ridha, Avanka Gunatilaka, Tasneem M Vaid, Martina Kocan, Alice R Whitehead, Michael DW Griffin, Ross AD Bathgate, Daniel J Scott, Paul R Gooley

Journal article

AbstractG-Protein Coupled Receptors (GPCRs) transmit signals across the cell membrane via an allosteric network from the ligand-bi..

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Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

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Projects

Molecular Determinants Of Drug Binding And Selectivity At Muscarinic Acetylcholine Receptors

Curation Of A Large-Scale Metabolite Dataset Via A Standardised Nmr Metabolomic Resource

Resolving And Targeting The Complex Molecular Mechanisms Underlying Gpcr Signalling

Defining The Molecular Mechanisms Of Lyssavirus Replication And Immune Evasion: The P Protein Axis

Preparative High Performance Liquid Chromatography System

Distributed Facility For Fragment Based Drug Discovery

Distributed Facility For Fragment Based Drug Discovery

Unravelling The Binding And Activation Mechanism Of A Complex G Protein-Coupled Receptor

Unravelling The Binding And Activation Mechanism Of A Complex G Protein-Coupled Receptor

A Longitudinal Study Of Gene Expression And Metabolic Profiling Changes That Occur In Chronic Fatigue Syndrome.

Novel Approaches To Understanding Peptide G-Protein-Coupled Receptor Activation

Novel Approaches To Understanding Peptide G-Protein-Coupled Receptor Activation

Interrogating Peptide Receptor Targets

Interrogating Peptide Receptor Targets

A Comprehensive Metabolomic Profile Of Chronic Fatigue Syndrome.

Determining Modes Of Binding And Activation Of Complex G-Protein Coupled Receptor Targets

Determining Modes Of Binding And Activation Of Complex G-Protein Coupled Receptor Targets

Defining The Interface Between An Essential Activating Protein Module And The G-Protein Coupled Receptor Rxfp1 By Solution Nmr

A 700 Mhz Nmr Spectrometer For The Melbourne Biomolecular Nmr Network: A High Throughput Resource

Using Protein Dynamics To Identify Novel Pathways Of Activation Of The Diabetes Enzyme Target Ampk

Advanced Characterisation Of Materials By Nuclear Magnetic Resonance

Explaining The Differences In Affinity And Of Carbohydrate Binding Of The Glycogen-Sensing Enzyme, Ampk

Metabolomics Of Chronic Fatigue Syndrome

Metabolomics Of The Gut Microbiota: Role In Health And The Influence Of Supplemented Diets

Functional Analysis Of Relaxin And Insl3 Receptors

Functional Analysis Of Relaxin And Insl3 Receptors

Investigating The Subunit Interactions Of A Molecular Protein Import Machine

Relaxin Family Peptide Receptors

The Role Of Lipids In Protein Misfolding And Amyloid-Related Diseases

Membrane Protein Structure And Interaction Facility

Evolution, Structure And Function Of Key Components In A Molecular Machine

Structural Investigations Of The Mitochondrial Protein Import Receptor Complex

Apolipoproteins And Amyloid Formation In Atheroma

The Activation Of Lipoprotein Lipase By Apolipoprotein C-Ii

Enhancing The Cardioprotective Effect Of Diadenosine Tetraphosphate: Designing Inhibitors Against Ap4a Hydrolase

Peptide Inhibitors Of Amyloid Fibril Formation

36

Projects

Project Types

Scholarly Works

Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface

THE STRUCTURE OF THE INTERLEUKIN 11 SIGNALLING COMPLEX

Post-Exertional Malaise Is Associated with Hypermetabolism, Hypoacetylation and Purine Metabolism Deregulation in ME/CFS Cases

Heteronuclear NMR spectroscopy of proteins encapsulated in cubic phase lipids

H-1, N-15 and C-13 resonance assignments of the C-terminal domain of the P protein of the Nishigahara strain of rabies virus

Diazepam is not a direct allosteric modulator of alpha(1)-adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase-4

Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis

Expression and Purification of a Functional E. coli 13CH3-Methionine-Labeled Thermostable Neurotensin Receptor 1 Variant for Solution NMR Studies.

Polymorphism in disease-related apolipoprotein C-II amyloid fibrils: a structural model for rod-like fibrils

The relaxin receptor as a therapeutic target - perspectives from evolution Cheek for updates and drug targeting

Optimization and (CH3)-C-13 methionine labeling of a signaling competent neurotensin receptor 1 variant for NMR studies

Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length

Determinants of Ligand Subtype-Selectivity at alpha(1A)-Adrenoceptor Revealed Using Saturation Transfer Difference (STD) NMR