Paul Gooley

Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL

Ashish Sethi, Christopher Horne, Cheree Fitzgibbon, Karyn Wilde, Katherine Davies, Sarah Garnish, Annette Jacobsen, André Samson, Joanne Hildebrand, Ahmad Wardak, Peter Czabotar, Emma Petrie, Paul Gooley, James Murphy

Journal article  |  2021

ABSTRACT Necroptosis is a lytic programmed cell death pathway with origins in innate immunity that is frequently dysregulated in i..

Bugs and Brains, the Gut and Mental Health Study: a mixed-methods study investigating microbiota composition and function in anxiety, depression and irritable bowel syndrome

Carra A Simpson, Orli S Schwartz, Djamila Eliby, Catherine A Butler, Katherine Huang, Neil O'Brien-Simpson, Bridget L Callaghan, Stuart G Dashper, Paul R Gooley, Sarah Whittle, Nick Haslam, Julian G Simmons

Journal article  |  2021  |  BMJ OPEN

INTRODUCTION: Research has highlighted relationships between the micro-organisms that inhabit our gastrointestinal tract (oral and..

Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38

Klara Kirsch, Andras Zeke, Orsolya Toke, Peter Sok, Ashish Sethi, Anna Sebo, Ganesan Senthil Kumar, Peter Egri, Adam L Poti, Paul Gooley, Wolfgang Peti, Isabel Bento, Anita Alexa, Attila Remenyi

Journal article  |  2020  |  NATURE COMMUNICATIONS

Transcription factor phosphorylation at specific sites often activates gene expression, but how environmental cues quantitatively ..

The Measles Virus V Protein Binding Site to STAT2 Overlaps That of IRF9

Yuma Nagano, Aoi Sugiyama, Madoka Kimoto, Takuya Wakahara, Yasuyo Noguchi, Xinxin Jiang, Shinya Saijo, Nobutaka Shimizu, Nana Yabuno, Min Yao, Paul R Gooley, Gregory W Moseley, Takashi Tadokoro, Katsumi Maenaka, Toyoyuki Ose

Journal article  |  2020  |  JOURNAL OF VIROLOGY

Measles virus (MeV) is a highly immunotropic and contagious pathogen that can even diminish preexisting antibodies and remains a m..

Structural comparison of the C-terminal domain of functionally divergent lyssavirus P proteins

Aoi Sugiyama, Tomo Nomai, Xinxin Jiang, Miku Minami, Min Yao, Katsumi Maenaka, Naoto Ito, Paul R Gooley, Gregory W Moseley, Toyoyuki Ose

Journal article  |  2020  |  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lyssavirus P protein is a multifunctional protein that interacts with numerous host-cell proteins. The C-terminal domain (CTD) of ..

INPHARMA-Based Determination of Ligand Binding Modes at alpha(1)-Adrenergic Receptors Explains the Molecular Basis of Subtype Selectivity

Tasneem M Vaid, David K Chalmers, Daniel J Scott, Paul R Gooley

Journal article  |  2020  |  CHEMISTRY-A EUROPEAN JOURNAL

The structural poses of ligands that bind weakly to protein receptors are challenging to define. In this work we have studied liga..

Conformational Changes in Tyrosine 11 of Neurotensin Are Required to Activate the Neurotensin Receptor 1

Fabian Bumbak, Trayder Thomas, Billy J Noonan-Williams, Tasneem M Vaid, Fei Yan, Alice R Whitehead, Shoni Bruell, Martina Kocan, Xuan Tan, Margaret A Johnson, Ross AD Bathgate, David K Chalmers, Paul R Gooley, Daniel J Scott

Journal article  |  2020  |  ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE

Cell-cell communication via endogenous peptides and their receptors is vital for controlling all aspects of human physiology and m..

N- and C-terminal regions of ?B-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation

Emily E Selig, Courtney O Zlatic, Dezerae Cox, Yee-Foong Mok, Paul R Gooley, Heath Ecroyd, Michael DW Griffin

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Small heat-shock proteins (sHSPs) are ubiquitously expressed molecular chaperones that inhibit amyloid fibril formation; however, ..

The structure of the extracellular domains of human interleukin 11? receptor reveals mechanisms of cytokine engagement

Riley D Metcalfe, Kaheina Aizel, Courtney O Zlatic, Paul M Nguyen, Craig J Morton, Daisy Sio-Seng Lio, Heung-Chin Cheng, Renwick CJ Dobson, Michael W Parker, Paul R Gooley, Tracy L Putoczki, Michael DW Griffin

Journal article  |  2020  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin (IL) 11 activates multiple intracellular signaling pathways by forming a complex with its cell surface α-receptor, IL-..

Probing the correlation between ligand efficacy and conformational diversity at the ?(1A)-adrenoreceptor reveals allosteric coupling of its microswitches

Feng-Jie Wu, Lisa M Williams, Alaa Abdul-Ridha, Avanka Gunatilaka, Tasneem M Vaid, Martina Kocan, Alice R Whitehead, Michael DW Griffin, Ross AD Bathgate, Daniel J Scott, Paul R Gooley

Journal article  |  2020  |  Journal of Biological Chemistry

G protein–coupled receptors (GPCRs) use a series of conserved microswitches to transmit signals across the cell membrane via an al..