Geoffrey Lindeman

Abstract 1130: First-in-class KAT6A/KAT6B inhibitor CTx-648 (PF-9363) demonstrates potent anti-tumor activity in ER breast cancer with KAT6A dysregulation

Shikhar Sharma, Jay Chung, Sean Uryu, Amanda Rickard, Natalie Nady, Showkhin Khan, Zhenxiong Wang, Yong Zhang, Haikuo Zhang, Pei-Pei Kung, Eric Greenwald, Karen Maegley, Patrick Bingham, Hieu Lam, Ylva E Bozikis, Hendrik Falk, Elizabeth Allan, Vicky M Avery, Miriam S Butler, Michelle A Camerino, et al.

Conference Proceedings  |  2021  |  Experimental and Molecular Therapeutics

Single cell transcriptome atlas of mouse mammary epithelial cells across development

Bhupinder Pal, Yunshun Chen, Michael JG Milevskiy, Francois Vaillant, Lexie Prokopuk, Caleb A Dawson, Bianca D Capaldo, Xiaoyu Song, Felicity Jackling, Paul Timpson, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2021  |  BREAST CANCER RESEARCH

BACKGROUND: Heterogeneity within the mouse mammary epithelium and potential lineage relationships have been recently explored by s..

Results from VERONICA: A randomized, phase II study of second-/third-line venetoclax (VEN) fulvestrant (F) versus F alone in estrogen receptor (ER)-positive, HER2-negative, locally advanced, or metastatic breast cancer (LA/MBC).

Geoffrey J Lindeman, Rebecca Bowen, Katarzyna Joanna Jerzak, Xinni Song, Thomas Decker, Frances M Boyle, Steven L McCune, Anne Armstrong, Catherine M Shannon, Gianfilippo Bertelli, Tharu M Fernando, Rupal Desai, Kushagra Gupta, Jerry Y Hsu, Aulde Flechais, Aditya Bardia

Journal article  |  2021  |  Journal of Clinical Oncology

1004 Background: For patients (pts) with ER-positive, HER2-negative MBC, CDK4/6 inhibitors + endocrine therapy (ET) is standard f..

A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast

Bhupinder Pal, Yunshun Chen, Francois Vaillant, Bianca D Capaldo, Rachel Joyce, Xiaoyu Song, Vanessa L Bryant, Jocelyn S Penington, Leon Di Stefano, Nina Tubau Ribera, Stephen Wilcox, Gregory B Mann, Anthony T Papenfuss, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2021  |  EMBO JOURNAL

To examine global changes in breast heterogeneity across different states, we determined the single-cell transcriptomes of > 340,0..

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

Christoph Grohmann, Francesca Walker, Mark Devlin, Meng-Xiao Luo, Anderly C Chueh, Judy Doherty, Francois Vaillant, Gwo-Yaw Ho, Matthew J Wakefield, Clare E Weeden, Alvin Kamili, Jayne Murray, Sela T Po'uha, Janet Weinstock, Serena R Kane, Maree C Faux, Esmee Broekhuizen, Ye Zheng, Kristy Shield-Artin, Nadia J Kershaw, et al.

Journal article  |  2021  |  CELL DEATH & DISEASE

Targeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limita..

Intravital microscopy of dynamic single-cell behavior in mouse mammary tissue

Caleb A Dawson, Scott N Mueller, Geoffrey J Lindeman, Anne C Rios, Jane E Visvader

Journal article  |  2021  |  NATURE PROTOCOLS

Multiphoton intravital imaging is essential for understanding cellular behavior and function in vivo. The adipose-rich environment..

Abstract OT-27-01: PALVEN: A phase 1b study of palbociclib, letrozole and venetoclax in estrogen receptor, BCL2-positive metastatic breast cancer

Christine Muttiah, Avraham Travers, James R Whittle, Sarah-Jane Dawson, Belinda Yeo, Jane E Visvader, Catherine Oakman, Geoffrey J Lindeman

Conference Proceedings  |  2021  |  Ongoing Clinical Trials Abstracts

Abstract OT-28-03: VICKI: A Phase Ib/II, randomized, placebo-controlled, study of venetoclax plus ado-trastuzumab emtansine (T-DM1) in patients (pts) with previously treated HER2-positive locally advanced (LA) or metastatic breast cancer (MBC)

Geoffrey J Lindeman, Erika Hamilton, Ian Krop, Bora Lim, Shanu Modi, Cristina Saura, Rupal Desai, Bradford J Danner, Tharu M Fernando, Shengchun Kong, Fatema A Legrand, Federico Nasroulah

Conference Proceedings  |  2021  |  Ongoing Clinical Trials Abstracts

Winpro: A window of opportunity study of endocrine therapy with and without prometrium in postmenopausal women with early stage hormone receptor-positive breast cancer

Brandon Lau, Davendra Segara, Andrew Ong, Janne Bingham, Belinda Kiely, Emma-Kate Carson, Julia Chen, Cindy Mak, Sanjay Warrier, Mun Hui, Kate Middleton, Andrew Parker, Bruce Mann, Geoffrey Lindeman, Wayne Tilley, Elgene Lim

Conference Proceedings  |  2021  |  CANCER RESEARCH

Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8 T cells

Clara Gomez-Aleza, Bastien Nguyen, Guillermo Yoldi, Marina Ciscar, Alexandra Barranco, Enrique Hernandez-Jimenez, Marion Maetens, Roberto Salgado, Maria Zafeiroglou, Pasquale Pellegrini, David Venet, Soizic Garaud, Eva M Trinidad, Sandra Benitez, Peter Vuylsteke, Laura Polastro, Hans Wildiers, Philippe Simon, Geoffrey Lindeman, Denis Larsimont, et al.

Journal article  |  2020  |  NATURE COMMUNICATIONS

Most breast cancers exhibit low immune infiltration and are unresponsive to immunotherapy. We hypothesized that inhibition of the ..