Geoffrey Lindeman

Stem Cells and the Differentiation Hierarchy in Mammary Gland Development.

Nai Yang Fu, Emma Nolan, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2020  |  Physiological Reviews

The mammary gland is a highly dynamic organ that undergoes profound changes within its epithelium during puberty and the reproduct..

Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers

Elizabeth C Page, Elizabeth K Bancroft, Mark N Brook, Melissa Assel, Mona Hassan Al Battat, Sarah Thomas, Natalie Taylor, Anthony Chamberlain, Jennifer Pope, Holly Ni Raghallaigh, D Gareth Evans, Jeanette Rothwell, Lovise Maehle, Eli Marie Grindedal, Paul James, Lyon Mascarenhas, Joanne McKinley, Lucy Side, Tessy Thomas, Christi van Asperen, et al.

Journal article  |  2019  |  European Urology

BACKGROUND: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluatin..

Development and validation of a targeted gene sequencing panel for application to disparate cancers.

Mark J McCabe, Marie-Emilie A Gauthier, Chia-Ling Chan, Tanya J Thompson, Sunita MC De Sousa, Clare Puttick, John P Grady, Velimir Gayevskiy, Jiang Tao, Kevin Ying, Arcadi Cipponi, Niantao Deng, Alex Swarbrick, Melissa L Thomas, Reginald V Lord, Amber L Johns, Maija Kohonen-Corish, Sandra A O'Toole, Jonathan Clark, Simon A Mueller, et al.

Journal article  |  2019  |  Scientific Reports

Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology ..

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca, Sandra Viz Lasheras, Roser Pujol, Johanna Kiiski, Taru A Muranen, Daniel R Barnes, Joe Dennis, Kyriaki Michailidou, Manjeet K Bolla, Goska Leslie, Cora M Aalfs, Muriel A Adank, Julian Adlard, Simona Agata, Karen Cadoo, Bjarni A Agnarsson, Thomas Ahearn, et al.

Journal article  |  2019  |  npj Breast Cancer

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1..

Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids.

Johanna F Dekkers, James R Whittle, François Vaillant, Huei-Rong Chen, Caleb Dawson, Kevin Liu, Maarten Geurts, Marco J Herold, Hans Clevers, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2019  |  JNCI: Journal of the National Cancer Institute

Breast cancer is characterized by histological and functional heterogeneity, posing a clinical challenge for patient treatment. Em..

Experiences and interpretations of BRCA1/2 testing among women affected by breast or ovarian cancer who received a negative result

Lesley Stafford, Alison Flehr, Fiona Judd, Geoffrey J Lindeman, Penny Gibson, Angela Komiti, G Bruce Mann, Maira Kentwell

Journal article  |  2019  |  Journal of Community Genetics

The aim of this study was to retrospectively describe the genetic testing motives and experiences of women with a previous breast ..

Iniparib administered weekly or twice-weekly in combination with gemcitabine/carboplatin in patients with metastatic triple-negative breast cancer: a phase II randomized open-label study with pharmacokinetics

Veronique Dieras, Herve Bonnefoi, Emilio Alba, Ahmad Awada, Bruno Coudert, Xavier Pivot, Joseph Gligorov, Agnes Jager, Stefania Zambelli, Geoffrey J Lindeman, Eric Charpentier, Gary T Emmons, Ignacio Garcia-Ribas, Robert Paridaens, Jaap Verweij

Journal article  |  2019  |  Breast Cancer Research and Treatment

PURPOSE: Metastatic triple-negative breast cancer (TNBC) is a phenotypic breast cancer subgroup with a very poor prognosis, despit..

Homologous recombination DNA repair defects in PALB2-associated breast cancers

Anqi Li, Felipe C Geyer, Pedro Blecua, Ju Youn Lee, Pier Selenica, David N Brown, Fresia Pareja, Simon SK Lee, Rahul Kumar, Barbara Rivera, Rui Bi, Salvatore Piscuoglio, Hannah Y Wen, John R Lozada, Rodrigo Gularte-Merida, Luca Cavallone, Zoulikha Rezoug, Tu Nguyen-Dumont, Paolo Peterlongo, Carlo Tondini, et al.

Journal article  |  2019  |  npj Breast Cancer

Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging.

Anne C Rios, Bianca D Capaldo, François Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, undefined 3DTCLSM Group, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2019  |  Cancer Cell

Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging

Anne C Rios, Bianca D Capaldo, Francois Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader, Jamie R Flynn, William M Palmer, Antony P Martin, et al.

Journal article  |  2019  |  Cancer Cell

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer

Sheau W Lok, James R Whittle, Francois Vaillant, Charis E Teh, Louisa L Lo, Antonia N Policheni, Alice RT Bergin, Jayesh Desai, Sarah Ftouni, Luke C Gandolfo, Danny Liew, He K Liu, G Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W Roberts, Mark A Rosenthal, Kylie Shackleton, Maria Joao Silva, et al.

Journal article  |  2019  |  Cancer Discovery

Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

D Merino, TS Weber, A Serrano, F Vaillant, K Liu, B Pal, L Di Stefano, J Schreuder, D Lin, Y Chen, ML Asselin-Labat, TN Schumacher, D Cameron, GK Smyth, AT Papenfuss, GJ Lindeman, JE Visvader, SH Naik

Journal article  |  2019  |  Nature Communications

Tailored NEOadjuvant epirubicin, cyclophosphamide and Nanoparticle Albumin-Bound paclitaxel for breast cancer: The phase II NEONAB trial-Clinical outcomes and molecular determinants of response

Caitlin Murphy, Andrea Muscat, David Ashley, Violet Mukaro, Linda West, Yang Liao, David Chisanga, Wei Shi, Ian Collins, Sally Baron-Hay, Sujata Patil, Geoffrey Lindeman, Mustafa Khasraw

Journal article  |  2019  |  PloS one

Phase 1 trial of olaparib and oral cyclophosphamide in BRCA breast cancer, recurrent BRCA ovarian cancer, non-BRCA triple-negative breast cancer, and non-BRCA ovarian cancer

Chee Khoon Lee, Clare Scott, Geoffrey J Lindeman, Anne Hamilton, Elizabeth Lieschke, Emma Gibbs, Rebecca Asher, Heath Badger, Robin Paterson, Lauren Macnab, Edmond Michael Kwan, Prudence A Francis, Frances Boyle, Michael Friedlander

Journal article  |  2019  |  British Journal of Cancer

Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations

Elizabeth K Bancroft, Sibel Saya, Elizabeth C Page, Kathryn Myhill, Sarah Thomas, Jennifer Pope, Anthony Chamberlain, Rachel Hart, Wayne Glover, Jackie Cook, Derek J Rosario, Brian T Helfand, Christina Hutten Selkirk, Rosemarie Davidson, Mark Longmuir, Diana M Eccles, Neus Gadea, Carole Brewer, Julian Barwell, Monica Salinas, et al.

Journal article  |  2019  |  BJU International

Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer

Stefano Annunziato, Julian R de Ruiter, Linda Henneman, Chiara S Brambillasca, Catrin Lutz, Francois Vaillant, Federica Ferrante, Anne Paulien Drenth, Eline van der Burg, Bjorn Siteur, Bas van Gerwen, Roebi de Bruijn, Martine H van Miltenburg, Ivo J Huijbers, Marieke van de Ven, Jane E Visvader, Geoffrey J Lindeman, Lodewyk FA Wessels, Jos Jonkers

Journal article  |  2019  |  Nature Communications

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Nai Yang Fu, Bhupinder Pal, Yunshun Chen, Felicity C Jackling, Michael Milevskiy, Francois Vaillant, Bianca D Capaldo, Fusheng Guo, Kevin H Liu, Anne C Rios, Nicholas Lim, Andrew J Kueh, David M Virshup, Marco J Herold, Haley O Tucker, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2018  |  Developmental Cell

Frequent activating STAT3 mutations and novel recurrent genomic abnormalities detected in breast implant-associated anaplastic large cell lymphoma.

Piers Blombery, Ella Thompson, Georgina L Ryland, Rachel Joyce, David J Byrne, Christine Khoo, Stephen Lade, Mark Hertzberg, Greg Hapgood, Paula Marlton, Anand Deva, Geoffrey Lindeman, Stephen Fox, David Westerman, Miles Prince

Journal article  |  2018  |  Oncotarget

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare form of T-cell lymphoma that occurs after implantati..

Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids

Ewa M Michalak, Michael JG Milevskiy, Rachel M Joyce, Johanna F Dekkers, Paul R Jamieson, Bhupinder Pal, Caleb A Dawson, Yifang Hu, Stuart H Orkin, Warren S Alexander, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2018  |  PLOS Biology

D-BEYOND: A window of opportunity trial evaluating denosumab, a RANK-ligand (RANKL) inhibitor and its biological effects in young pre-menopausal women diagnosed with early breast cancer

Bastien Nguyen, Marion Maetens, Roberto Salgado, David Venet, Peter Vuylsteke, Laura Polastro, Hans Wieldiers, Philippe Simon, Geoff Lindeman, Denis Larsimont, Gert Van den Eynden, Chloe Velghe, Francoise Rothe, Soizic Garaud, Stefan Michiels, Karen Willard-gallo, Hatem A Azim, Sherene Loi, Martine Piccart, Christos Sotiriou

Conference Proceedings  |  2018  |  Clinical Trials

Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

Christos Mikropoulos, Christina G Hutten Selkirk, Sibel Saya, Elizabeth Bancroft, Emily Vertosick, Tokhir Dadaev, Charles Brendler, Elizabeth Page, Alexander Dias, D Gareth Evans, Jeanette Rothwell, Lovise Maehle, Karol Axcrona, Kate Richardson, Diana Eccles, Thomas Jensen, Palle J Osther, Christi J van Asperen, Hans Vasen, Lambertus A Kiemeney, et al.

Journal article  |  2018  |  British Journal of Cancer

Spotlight on the utility of the Oncotype DX (R) breast cancer assay

Zhen Rong Siow, Richard H De Boer, Geoffrey J Lindeman, G Bruce Mann

Journal article  |  2018  |  International Journal of Women's Health

Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling

Bhupinder Pal, Yunshun Chen, Francois Vaillant, Paul Jamieson, Lavinia Gordon, Anne C Rios, Stephen Wilcox, Naiyang Fu, Kevin He Liu, Felicity C Jackling, Melissa J Davis, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2017  |  Nature Communications

RE: Bilateral Oophorectomy and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Emma Nolan, Francois Vaillant, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2017  |  JNCI: Journal of the National Cancer Institute

Preferences for breast cancer risk reduction among BRCA1/BRCA2 mutation carriers: a discrete-choice experiment

Alexander Liede, Carol A Mansfield, Kelly A Metcalfe, Melanie A Price, Carrie Snyder, Henry T Lynch, Sue Friedman, Justyna Amelio, Joshua Posner, Steven A Narod, Geoffrey J Lindeman, D Gareth Evans

Journal article  |  2017  |  Breast Cancer Research and Treatment

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

Delphine Merino, James R Whittle, Francois Vaillant, Antonin Serrano, Jia-Nan Gong, Goknur Giner, Ana Leticia Maragno, Maia Chanrion, Emilie Schneider, Bhupinder Pal, Xiang Li, Grant Dewson, Julius Grasel, Kevin Liu, Najoua Lalaoui, David Segal, Marco J Herold, David CS Huang, Gordon K Smyth, Olivier Geneste, et al.

Journal article  |  2017  |  Science Translational Medicine

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

Emma Nolan, Peter Savas, Antonia N Policheni, Phillip K Darcy, Francois Vaillant, Christopher P Mintoff, Sathana Dushyanthen, Mariam Mansour, Jia-Min B Pang, Stephen B Fox, Charles M Perou, Jane E Visvader, Daniel HD Gray, Sherene Loi, Geoffrey J Lindeman

Journal article  |  2017  |  Science Translational Medicine

Safety and efficacy of the BCL2 inhibitor venetoclax in estrogen receptor (ER) and BCL2-positive metastatic breast cancer: The mBEP study.

Geoffrey John Lindeman, Sheau Wen Lok, Alice Ruth Bergin, James Richard Whittle, Kylie Shackleton, Peter Sherman, Sarah-Jane Dawson, Jayesh Desai, Danny Liew, Bruce Mann, Anand Murugasu, Andrew Warwick Roberts, Mark Rosenthal, Jane Visvader

Conference Proceedings  |  2017  |  Journal of Clinical Oncology

Solitary pituitary metastasis from HER2-positive breast cancer

Jeremy Kam, Jeffrey Kam, G Bruce Mann, Claire Phillips, John M Wentworth, James King, Geoffrey J Lindeman

Journal article  |  2017  |  Asia-Pacific Journal of Clinical Oncology

Patient and medical barriers preclude uptake of tamoxifen preventative therapy in women with a strong family history

Anita R Skandarajah, Susan Thomas, Kylie Shackleton, Laura Chin-Lenn, Geoffrey J Lindeman, G Bruce Mann

Journal article  |  2017  |  The Breast

Mainstreaming cancer genetics: A model integrating germline BRCA testing into routine ovarian cancer clinics

Maira Kentwell, Eryn Dow, Yoland Antill, C David Wrede, Orla McNally, Emily Higgs, Anne Hamilton, Sumitra Ananda, Geoffrey J Lindeman, Clare L Scott

Journal article  |  2017  |  Gynecologic Oncology

Derivation of a robust mouse mammary organoid system for studying tissue dynamics

Paul R Jamieson, Johanna F Dekkers, Anne C Rios, Nai Yang Fu, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2017  |  Development

Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive

Nai Yang Fu, Anne C Rios, Bhupinder Pal, Charity W Law, Paul Jamieson, Ruijie Liu, Francois Vaillant, Felicity Jackling, Kevin He Liu, Gordon K Smyth, Geoffrey J Lindeman, Matthew E Ritchie, Jane E Visvader

Journal article  |  2017  |  Nature Cell Biology

New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells

Carmel M O'Brien, Hun S Chy, Qi Zhou, Shiri Blumenfeld, Jack W Lambshead, Xiaodong Liu, Joshua Kie, Bianca D Capaldo, Tung-Liang Chung, Timothy E Adams, Phan Tram, John D Bentley, William J McKinstry, Karen Oliva, Paul J McMurrick, Yu-Chieh Wang, Fernando J Rossello, Geoffrey J Lindeman, Di Chen, Thierry Jarde, et al.

Journal article  |  2017  |  STEM CELLS

Out-RANKing BRCA1 in Mutation Carriers

Emma Nolan, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2017  |  Cancer Research

RANK ligand as a target for breast cancer prevention in BRCA1 mutation carriers

GJ Lindeman, E Nolan, F Vaillant, D Branstetter, B Pal, G Giner, L Whitehead, SW Lok, GB Mann, K Rohrbach, L-Y Huang, R Soriano, GK Smyth, WC Dougall, JE Visvader

Conference Proceedings  |  2017  |  General Session Abstracts

Patient-derived xenograft (PDX) models in basic and translational breast cancer research

Lacey E Dobrolecki, Susie D Airhart, Denis G Alferez, Samuel Aparicio, Fariba Behbod, Mohamed Bentires-Alj, Cathrin Brisken, Carol J Bult, Shirong Cai, Robert B Clarke, Heidi Dowst, Matthew J Ellis, Eva Gonzalez-Suarez, Richard D Iggo, Peter Kabos, Shunqiang Li, Geoffrey J Lindeman, Elisabetta Marangoni, Aaron McCoy, Funda Meric-Bernstam, et al.

Journal article  |  2016  |  Cancer and Metastasis Reviews

The complexities and caveats of lineage tracing in the mammary gland

Anne C Rios, Nai Yang Fu, Joseph Cursons, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2016  |  Breast Cancer Research

Triple negative breast cancer: proven and promising systemic therapies

Alice Bergin, Catherine Oakman, Geoffrey J Lindeman

Journal article  |  2016  |  Cancer Forum

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

Kate Lawrenson, Siddhartha Kar, Karen McCue, Karoline Kuchenbaeker, Kyriaki Michailidou, Jonathan Tyrer, Jonathan Beesley, Susan J Ramus, Qiyuan Li, Melissa K Delgado, Janet M Lee, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Banu K Arun, Brita Arver, Elisa V Bandera, Monica Barile, Rosa B Barkardottir, et al.

Journal article  |  2016  |  Nature Communications

RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers

Emma Nolan, Francois Vaillant, Daniel Branstetter, Bhupinder Pal, Goeknur Giner, Lachlan Whitehead, Sheau W Lok, Gregory B Mann, Kathy Rohrbach, Li-Ya Huang, Rosalia Soriano, Gordon K Smyth, William C Dougall, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2016  |  Nature Medicine

Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer

D Merino, SW Lok, JE Visvader, GJ Lindeman

Journal article  |  2016  |  Oncogene

Essential role for a novel population of binucleated mammary epithelial cells in lactation

Anne C Rios, Nai Yang Fu, Paul R Jamieson, Bhupinder Pal, Lachlan Whitehead, Kevin R Nicholas, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2016  |  Nature Communications

Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2

D Merino, SA Best, M-L Asselin-Labat, F Vaillant, B Pal, RA Dickins, RL Anderson, A Strasser, P Bouillet, GJ Lindeman, JE Visvader

Journal article  |  2015  |  Oncogene

Integration of microRNA signatures of distinct mammary epithelial cell types with their gene expression and epigenetic portraits

Bhupinder Pal, Yunshun Chen, Andrew Bert, Yifang Hu, Julie M Sheridan, Tamara Beck, Wei Shi, Keith Satterley, Paul Jamieson, Gregory J Goodall, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2015  |  Breast Cancer Research

Large genomic rearrangements in the familial breast and ovarian cancer gene BRCA1 are associated with an increased frequency of high risk features

Paul A James, Sarah Sawyer, Samantha Boyle, Mary-Anne Young, Serguei Kovalenko, Rebecca Doherty, Joanne McKinley, Kathryn Alsop, Victoria Beshay, Marion Harris, Stephen Fox, Geoffrey J Lindeman, Gillian Mitchell

Journal article  |  2015  |  Familial Cancer

A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1

Julie M Sheridan, Matthew E Ritchie, Sarah A Best, Kun Jiang, Tamara J Beck, Francois Vaillant, Kevin Liu, Ross A Dickins, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2015  |  BMC Cancer

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival

Nai Yang Fu, Anne C Rios, Bhupinder Pal, Rina Soetanto, Aaron TL Lun, Kevin Liu, Tamara Beck, Sarah A Best, Francois Vaillant, Philippe Bouillet, Andreas Strasser, Thomas Preiss, Gordon K Smyth, Rey J Lindeman, Jane E Visvader

Journal article  |  2015  |  Nature Cell Biology

Patient-derived xenograft models of breast cancer and their predictive power

James R Whittle, Michael T Lewis, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2015  |  Breast Cancer Research

Patient-derived xenograft models of breast cancer and their predictive power.

James R Whittle, Michael T Lewis, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2015  |  Breast cancer research : BCR

Despite advances in the treatment of patients with early and metastatic breast cancer, mortality remains high due to intrinsic or ..

In situ identification of bipotent stem cells in the mammary gland

AC Rios, N Fu, G Lindeman, J Visvader

Conference Proceedings  |  2014  |  FEBS JOURNAL

Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study

Elizabeth K Bancroft, Elizabeth C Page, Elena Castro, Hans Lilja, Andrew Vickers, Daniel Sjoberg, Melissa Assel, Christopher S Foster, Gillian Mitchell, Kate Drew, Lovise Maehle, Karol Axcrona, D Gareth Evans, Barbara Bulman, Diana Eccles, Donna McBride, Christi van Asperen, Hans Vasen, Lambertus A Kiemeney, Janneke Ringelberg, et al.

Journal article  |  2014  |  European Urology

Breast-Cancer Risk in Families with Mutations in PALB2

AC Antoniou, S Casadei, T Heikkinen, D Barrowdale, K Pylkaes, J Roberts, A Lee, D Subramanian, K De Leeneer, F Fostira, E Tomiak, SL Neuhausen, ZL Teo, S Khan, K Aittomaeki, JS Moilanen, C Turnbull, S Seal, A Mannermaa, A Kallioniemi, et al.

Journal article  |  2014  |  New England Journal of Medicine

Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary

Sarah A Best, Karla J Hutt, Nai Yang Fu, Francois Vaillant, Seng H Liew, Lynne Hartley, Clare L Scott, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2014  |  Development

Breast cancer prevention for BRCA1 and BRCA2 mutation carriers: is there a role for tamoxifen?

Kelly-Anne Phillips, Geoffrey J Lindeman

Journal article  |  2014  |  Future Oncology

In situ identification of bipotent stem cells in the mammary gland

Anne C Rios, Nai Yang Fu, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2014  |  Nature

The Mammary Stem Cell Hierarchy

Naiyang Fu, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2014  |  Current topics in developmental biology

The incidence of PALB2 c.3113G > A in women with a strong family history of breast and ovarian cancer attending familial cancer centres in Australia

Zhi L Teo, Sarah D Sawyer, Paul A James, Gillian Mitchell, Alison H Trainer, Geoffrey J Lindeman, Kylie Shackleton, Linda Cicciarelli, Melissa C Southey

Journal article  |  2013  |  Familial Cancer

The Angelina Jolie effect

Paul A James, Gillian Mitchell, Michael Bogwitz, Geoffrey J Lindeman

Journal article  |  2013  |  Medical Journal of Australia

Distinct nuclear receptor expression in stroma adjacent to breast tumors

Kevin C Knower, Ashwini L Chand, Natalie Eriksson, Kiyoshi Takagi, Yasuhiro Miki, Hironobu Sasano, Jane E Visvader, Geoffrey J Lindeman, John W Funder, Peter J Fuller, Evan R Simpson, Wayne D Tilley, Peter J Leedman, J Dinny Graham, George EO Muscat, Christine L Clarke, Colin D Clyne

Journal article  |  2013  |  Breast Cancer Research and Treatment

Role of the transcription factor Id4 in the developing mammary gland

Sarah A Best, NaiYang Fu, Francois Vaillant, Geoff J Lindeman, Jane E Visvader

Journal article  |  2013  |  Stem Cells - Mammary Lineage Tracing

Mammary epithelial subtypes and their implications for breast cancer

Anne Rios, Naiyang Fu, Bhupinder Pal, Geoffrey Lindeman, Jane Visvader

Journal article  |  2013  |  Stem Cells - Mammary Lineage Tracing

Tumour morphology predicts PALB2 germline mutation status

ZL Teo, E Provenzano, GS Dite, DJ Park, C Apicella, SD Sawyer, PA James, G Mitchell, AH Trainer, GJ Lindeman, K Shackleton, L Cicciarelli, SS Buys, IL Andrulis, AM Mulligan, G Glendon, EM John, MB Terry, M Daly, FA Odefrey, et al.

Journal article  |  2013  |  British Journal of Cancer

Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer

Francois Vaillant, Delphine Merino, Lily Lee, Kelsey Breslin, Bhupinder Pal, Matthew E Ritchie, Gordon K Smyth, Michael Christie, Louisa J Phillipson, Christopher J Burns, G Bruce Mann, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2013  |  Cancer Cell

Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetically high risk men

Emma Killick, Richard Morgan, Francesca Launchbury, Elizabeth Bancroft, Elizabeth Page, Elena Castro, Zsofia Kote-Jarai, Armen Aprikian, Ignacio Blanco, Virginia Clowes, Susan Domchek, Fiona Douglas, Diana Eccles, D Gareth Evans, Marion Harris, Judy Kirk, Jimmy Lam, Geoffrey Lindeman, Gillian Mitchell, Nicholas Pachter, et al.

Journal article  |  2013  |  Scientific Reports

Global Changes in the Mammary Epigenome Are Induced by Hormonal Cues and Coordinated by Ezh2

Bhupinder Pal, Toula Bouras, Wei Shi, Francois Vaillant, Julie M Sheridan, Naiyang Fu, Kelsey Breslin, Kun Jiang, Matthew E Ritchie, Matthew Young, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2013  |  Cell Reports

Phase I trial of the oral PARP inhibitor olaparib in combination with paclitaxel for first-or second-line treatment of patients with metastatic triple-negative breast cancer

Rebecca A Dent, Geoffrey J Lindeman, Mark Clemons, Hans Wildiers, Arlene Chan, Nicole J McCarthy, Christian F Singer, Elizabeth S Lowe, Claire L Watkins, James Carmichael

Journal article  |  2013  |  Breast Cancer Research

A Role for Common Genomic Variants in the Assessment of Familial Breast Cancer

Sarah Sawyer, Gillian Mitchell, Joanne McKinley, Georgia Chenevix-Trench, Jonathan Beesley, Xiao Qing Chen, David Bowtell, Alison H Trainer, Marion Harris, Geoffrey J Lindeman, Paul A James

Journal article  |  2012  |  Journal of Clinical Oncology

Cancer Stem Cells: Current Status and Evolving Complexities

Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2012  |  Cell Stem Cell

Isolation of Mouse Mammary Epithelial Subpopulations: A Comparison of Leading Methods

Matthew J Smalley, Howard Kendrick, Julie M Sheridan, Joseph L Regan, Michael D Prater, Geoffrey J Lindeman, Christine J Watson, Jane E Visvader, John Stingl

Journal article  |  2012  |  Journal of Mammary Gland Biology and Neoplasia

Triple-negative breast cancer: making the most of a misnomer

Nicole Mccarthy, Gillian Mitchell, Michael Bilous, Nicholas Wilcken, Geoffrey J Lindeman

Journal article  |  2012  |  Asia-Pacific Journal of Clinical Oncology

Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

Samantha R Oakes, Francois Vaillant, Elgene Lim, Lily Lee, Kelsey Breslin, Frank Feleppa, Siddhartha Deb, Matthew E Ritchie, Elena Takano, Teresa Ward, Stephen B Fox, Daniele Generali, Gordon K Smyth, Andreas Strasser, David CS Huang, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

Aldehyde Dehydrogenase Activity Is a Biomarker of Primitive Normal Human Mammary Luminal Cells

Peter Eirew, Nagarajan Kannan, David JHF Knapp, Francois Vaillant, Joanne T Emerman, Geoffrey J Lindeman, Jane E Visvader, Connie J Eaves

Journal article  |  2012  |  Stem Cells

Analysis of RAD51C Germline Mutations in High-Risk Breast and Ovarian Cancer Families and Ovarian Cancer Patients

Ella R Thompson, Samantha E Boyle, Julie Johnson, Georgina L Ryland, Sarah Sawyer, David YH Choong, Georgia Chenevix-Trench, Alison H Trainer, Geoffrey J Lindeman, Gillian Mitchell, Paul A James, Ian G Campbell

Journal article  |  2012  |  Human Mutation

The unmasking of novel unipotent stem cells in the mammary gland

Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2011  |  EMBO Journal

Breast Conservation Versus Mastectomy in Triple-Negative Breast Cancer: Two Steps Forward, One Step Back?

Alison H Trainer, Paul A James, G Bruce Mann, Geoffrey J Lindeman

Journal article  |  2011  |  Journal of Clinical Oncology

Challenges to the Development of New Agents for Molecularly Defined Patient Subsets: Lessons From BRCA1/2-Associated Breast Cancer

Susan M Domchek, Gillian Mitchell, Geoffrey J Lindeman, Nadine M Tung, Judith Balmana, Steven J Isakoff, Rita Schmutzler, M William Audeh, Niklas Loman, Clare Scott, Michael Friedlander, Bella Kaufman, Judy E Garber, Andrew Tutt, Mark E Robson

Journal article  |  2011  |  Journal of Clinical Oncology

Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14

Marie-Liesse Asselin-Labat, Kate D Sutherland, Francois Vaillant, David E Gyorki, Di Wu, Sheridan Holroyd, Kelsey Breslin, Teresa Ward, Wei Shi, Mary L Bath, Siddhartha Deb, Stephen B Fox, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2011  |  Molecular and Cellular Biology

Proteomic profiling of secretome and adherent plasma membranes from distinct mammary epithelial cell subpopulations

Hong Ji, Robert JA Goode, Francois Vaillant, Suresh Mathivanan, Eugene A Kapp, Rommel A Mathias, Geoffrey J Lindeman, Jane E Visvader, Richard J Simpson

Journal article  |  2011  |  Proteomics

The role of poly adenosine diphosphate ribose polymerase inhibitors in breast and ovarian cancer: Current status and future directions

Fiona Chionh, Gillian Mitchell, Geoffrey J Lindeman, Michael Friedlander, Clare L Scott

Journal article  |  2011  |  Asia-Pacific Journal of Clinical Oncology

An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition

Philip A Gregory, Cameron P Bracken, Eric Smith, Andrew G Bert, Josephine A Wright, Suraya Roslan, Melanie Morris, Leila Wyatt, Gelareh Farshid, Yat-Yuen Lim, Geoffrey J Lindeman, M Frances Shannon, Paul A Drew, Yeesim Khew-Goodall, Gregory J Goodall

Journal article  |  2011  |  Molecular Biology of the Cell

Mammary stem cells and their regulation by steroid hormones.

Marie-Liesse Asselin-Labat, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2011  |  Expert Review of Endocrinology & Metabolism

Sustained exposure to estrogen and progesterone is a well-established risk factor for breast cancer. These hormones play a central..

Hereditary Breast Cancer Genetics-From Clinical Curiosities to Mainstream Paradigms PREFACE

GJ Lindeman, JE Visvader

Journal article  |  2011  |  Journal of Mammary Gland Biology and Neoplasia

Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit

CE Smart, A Wronski, JD French, SL Edwards, M-L Asselin-Labat, N Waddell, K Peters, BL Brewster, K Brooks, K Simpson, N Manning, SR Lakhani, S Grimmond, GJ Lindeman, JE Visvader, MA Brown

Journal article  |  2011  |  Oncogene

LMO4 expression in squamous cell carcinoma of the anterior tongue

Rhonda A Kwong, Christopher J Scarlett, Larry H Kalish, Ian E Cole, James G Kench, Eleanor YM Sum, Elizabeth A Musgrove, Susan M Henshall, Geoffrey J Lindeman, Andrew V Biankin, Jane E Visvader, Robert L Sutherland

Journal article  |  2011  |  Histopathology

Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays?

Francois Vaillant, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2011  |  Breast Cancer Research

Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study

Anita V Mitra, Elizabeth K Bancroft, Yolanda Barbachano, Elizabeth C Page, CS Foster, C Jameson, G Mitchell, GJ Lindeman, A Stapleton, G Suthers, DG Evans, D Cruger, I Blanco, C Mercer, J Kirk, L Maehle, S Hodgson, L Walker, L Izatt, F Douglas, et al.

Journal article  |  2011  |  British Journal of Urology

Cell fate takes a slug in BRCA1-associated breast cancer

Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2011  |  Breast Cancer Research

The rs10993994 Risk Allele for Prostate Cancer Results in Clinically Relevant Changes in Microseminoprotein-Beta Expression in Tissue and Urine

Hayley C Whitaker, Zsofia Kote-Jarai, Helen Ross-Adams, Anne Y Warren, Johanna Burge, Anne George, Elizabeth Bancroft, Sameer Jhavar, Daniel Leongamornlert, Malgorzata Tymrakiewicz, Edward Saunders, Elizabeth Page, Anita Mitra, Gillian Mitchell, Geoffrey J Lindeman, D Gareth Evans, Ignacio Blanco, Catherine Mercer, Wendy S Rubinstein, Virginia Clowes, et al.

Journal article  |  2010  |  PLoS ONE

Stem cells and cancer - The promise and puzzles Preface

Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2010  |  Molecular Oncology

Control of mammary stem cell function by steroid hormone signalling

Marie-Liesse Asselin-Labat, Francois Vaillant, Julie M Sheridan, Bhupinder Pal, Di Wu, Evan R Simpson, Hisataka Yasuda, Gordon K Smyth, T John Martin, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2010  |  Nature

Insights into the cell of origin in breast cancer and breast cancer stem cells

Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2010  |  Asia-Pacific Journal of Clinical Oncology

Loss of STARD 10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status

Niamh C Murphy, Andrew V Biankin, Ewan KA Millar, Catriona M McNeil, Sandra A O'Toole, Davendra Segara, Paul Crea, Monilola A Olayioye, C Soon Lee, Stephen B Fox, Adrienne L Morey, Michael Christie, Elizabeth A Musgrove, Roger J Daly, Geoffrey J Lindeman, Susan M Henshall, Jane E Visvader, Robert L Sutherland

Journal article  |  2010  |  International Journal of Cancer

Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors

Jeremy M Arnold, David YH Choong, Ella R Thompson, Nic Waddell, Geoffrey J Lindeman, Jane E Visvader, Ian G Campbell, Georgia Chenevix-Trench

Journal article  |  2010  |  Breast Cancer Research and Treatment

Gene Methylation in Breast Ductal Fluid from BRCA1 and BRCA2 Mutation Carriers

Yoland C Antill, Gillian Mitchell, Sandra A Johnson, Lisa Devereux, Alvin Milner, Juliana Di Iuiio, Geoffrey J Lindeman, Judy Kirk, Kelly Anne Phillips, Ian G Campbell

Journal article  |  2010  |  Cancer Epidemiology, Biomarkers & Prevention

Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways

Elgene Lim, Di Wu, Bhupinder Pal, Toula Bouras, Marie-Liesse Asselin-Labat, Francois Vaillant, Hideo Yagita, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2010  |  Breast Cancer Research

Resident Macrophages Influence Stem Cell Activity in the Mammary Gland

DE Gyorki, GJ Lindeman, JE Visvader

Conference Proceedings  |  2009  |  CANCER RESEARCH

Lineage Enforcement by Inductive Mesenchyme on Adult Epithelial Stem Cells across Developmental Germ Layers

Renea A Taylor, Hong Wang, Sarah E Wilkinson, Michelle G Richards, Kara L Britt, Francois Vaillant, Geoffrey J Lindeman, Jane E Visvader, Gerald R Cunha, Justin St John, Gail P Risbridger

Journal article  |  2009  |  Stem Cells

Expression of S100A2 Calcium-Binding Protein Predicts Response to Pancreatectomy for Pancreatic Cancer

Andrew V Biankin, James G Kench, Emily K Colvin, Davendra Segara, Christopher J Scarlett, Nam Q Nguyen, David K Chang, Adrienne L Morey, C-Soon Lee, Mark Pinese, Samuel CL Kuo, Johana M Susanto, Peter H Cosman, Geoffrey J Lindeman, Jane E Visvader, Tuan V Nguyen, Neil D Merrett, Janindra Warusavitarne, Elizabeth A Musgrove, Susan M Henshall, et al.

Journal article  |  2009  |  Gastroenterology

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

Elgene Lim, Francois Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen, Frank Feleppa, Lily I Huschtscha, Heather J Thorne, Stephen B Fox, Max Yan, Juliet D French, Melissa A Brown, Gordon K Smyth, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2009  |  Nature Medicine

Investigation of human mammary stem and progenitor subpopulations from BRCA1 mutation carriers and noncarriers

E Lim, F Vaillant, D Wu, N Forrest, B Pal, D Gyorki, GK Smyth, J Visvader, G Lindeman

Conference Proceedings  |  2009  |  JOURNAL OF CLINICAL ONCOLOGY

Impaired Lactation in Mice Expressing Dominant-Negative FADD in Mammary Epithelium

Mark Shackleton, Lorraine A O'Reilly, Kate D Sutherland, Mary L Bath, Sarah Ellis, Andreas Strasser, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2009  |  Developmental Dynamics

Predictors of the use of complementary and alternative medicine (CAM) by women at high risk for breast cancer

KM Field, MA Jenkins, ML Friedlander, JM McKinley, MA Price, P Weideman, LA Keogh, SA McLachlan, GJ Lindeman, JL Hopper, PN Butow, KA Phillips

Journal article  |  2009  |  European Journal of Cancer

EpCAM and solid tumour fractionation

JE Visvader, GJ Lindeman

Journal article  |  2009  |  Nature Reviews Cancer

EpCAM and solid tumour fractionation

Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2009  |  Nature Reviews Cancer

Resident macrophages influence stem cell activity in the mammary gland

David E Gyorki, Marie-Liesse Asselin-Labat, Nico van Rooijen, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2009  |  Breast Cancer Research

Breast cancer risk and the BRCA1 interacting protein CTIP

Kylie L Gorringe, David YH Choong, Geoffrey J Lindeman, Jane E Visvader, Ian G Campbell

Journal article  |  2008  |  Breast Cancer Research and Treatment

Towards more effective and equitable genetic testing for BRCA1 and BRCA2 mutation carriers

PA James, M Harris, GJ Lindeman, G Mitchell

Journal article  |  2008  |  Journal of Medical Genetics

Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

Toula Bouras, Bhupinder Pal, Francois Vaillant, Gwyndolen Harburg, Marie-Liesse Asselin-Labat, Samantha R Oakes, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2008  |  CELL STEM CELL

Deaf-I regulates epithelial cell proliferation and side-branching in the mammary gland

Holly E Barker, Gordon K Smyth, James Wettenhall, Teresa A Ward, Mary L Bath, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2008  |  BMC Developmental Biology

BARD1 variants are not associated with breast cancer risk in Australian familial breast cancer

Kylie L Gorringe, David YH Choong, Jane E Visvader, Geoffrey J Lindeman, Ian G Campbell

Journal article  |  2008  |  Breast Cancer Research and Treatment

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2008  |  Nature Reviews Cancer

The mammary progenitor marker CD61/beta 3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis

Francois Vaillant, Marie-Liesse Asselin-Labat, Mark Shackleton, Natasha C Forrest, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2008  |  CANCER RESEARCH

Grhl3 and Lmo4 play coordinate roles in epidermal migration

Nikki R Hislop, Jacinta Caddy, Stephen B Ting, Alana Auden, Sumitha Vasudevan, Sarah L King, Geoffrey J Lindeman, Jane E Visvader, John M Cunningham, Stephen M Jane

Journal article  |  2008  |  Developmental Biology

The beliefs, and reported and intended behaviors of unaffected men in response to their family history of prostate cancer

Ruth Cowan, Bettina Meiser, Graham G Giles, Geoffrey J Lindeman, Clara L Gaff

Journal article  |  2008  |  Genetics in Medicine

Macrophages, more than just scavengers: Their role in breast development and cancer

David E Gyorki, Geoffrey J Lindeman

Journal article  |  2008  |  ANZ Journal of Surgery

The Ets transcription factor Elf5 specifies mammary alveolar cell fate

Samantha R Oakes, Matthew J Naylor, Marie-Liesse Asselin-Labat, Katrina D Blazek, Margaret Gardiner-Garden, Heidi N Hilton, Michael Kazlauskas, Melanie A Pritchard, Lewis A Chodosh, Peter L Pfeffer, Geoffrey J Lindeman, Jane E Visvader, Christopher J Ormandy

Journal article  |  2008  |  Genes & Development

Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma

NC Murphy, CJ Scarlett, JG Kench, EYM Sum, D Segara, EK Colvin, J Susanto, PH Cosman, C-S Lee, EA Musgrove, RL Sutherland, GJ Lindeman, SM Henshall, JE Visvader, AV Biankin

Journal article  |  2008  |  British Journal of Cancer

Cancer risk management practices of noncarriers within BRCA1/2 mutation - Positive families in the Kathleen Cuningham Foundation Consortium for Research into Familial Breast cancer

Sarah-Jane Dawson, Melanie A Price, Mark A Jenkins, Joanne M McKinley, Phyllis N Butow, Sue-Anne McLachlan, Geoffrey J Lindeman, Prue Weideman, Michael L Friedlander, John L Hopper, Kelly-Anne Phillips

Journal article  |  2008  |  Journal of Clinical Oncology

Delineating the Epithelial Hierarchy in the Mouse Mammary Gland

M-L Asselin-Labat, F Vaillant, M Shackleton, T Bouras, GJ Lindeman, JE Visvader

Journal article  |  2008  |  Cold Spring Harbor Symposia on Quantitative Biology

The future of mammary stem cell biology: the power of in vivo transplants

Geoffrey J Lindeman, Jane E Visvader, Matthew J Smalley, Connie J Eaves

Journal article  |  2008  |  Breast Cancer Research

Elucidating the stem and progenitor cell hierarchy in breast development and cancer - an essential role for GATA-3

GJ Lindeman, Asselin-Labal M-L, KD Sutherland, H Barker, R Thomas, M Shackleton, L Hartley, L Robb, FG Grosveld, der Wees J van, JE Visvader

Conference Proceedings  |  2007  |  BREAST CANCER RESEARCH AND TREATMENT

Prostate cancer screening in men with a family history of prostate cancer: The role of partners in influencing men's screening uptake

Bettina Meiser, Ruth Cowan, Anthony Costello, Graham G Giles, Geoff J Lindeman, Clara L Gaff

Journal article  |  2007  |  Urology

Prostate screening uptake in Australian BRCA1 and BRCA2 carriers

Joanne M McKinley, Prue C Weideman, Mark A Jenkins, Michael L Friedlander, John L Hopper, Sue-Anne McLachlan, Geoffrey J Lindeman, Kelly-Anne Phillips

Journal article  |  2007  |  Hereditary Cancer in Clinical Practice

Effects of a treatment gap during adjuvant chemotherapy in node-positive breast cancer: results of International Breast Cancer Study Group (IBCSG) Trials 13-93 and 14-93

Marco Colleoni, Shari Gelber, Edda Simoncini, Olivia Pagani, Richard D Gelber, Karen N Price, Monica Castiglione-Gertsch, Alan S Coates, Aron Goldhirsch, A Goldhirsch, AS Coates, B Thuerlimann, M Castiglione, AS Coates, JP Collins, H Cortes Funes, RD Gelber, A Goldhirsch, M Green, A Hiltbrunner, et al.

Journal article  |  2007  |  Annals of Oncology

Genome-wide association study identifies novel breast cancer susceptibility loci

Douglas F Easton, Karen A Pooley, Alison M Dunning, Paul DP Pharoah, Deborah Thompson, Dennis G Ballinger, Jeffery P Struewing, Jonathan Morrison, Helen Field, Robert Luben, Nicholas Wareham, Shahana Ahmed, Catherine S Healey, Richard Bowman, Kerstin B Meyer, Christopher A Haiman, Laurence K Kolonel, Brian E Henderson, Loic Le Marchand, Paul Brennan, et al.

Journal article  |  2007  |  Nature

Knocking off SOCS genes in the mammary gland

Kate D Sutherland, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2007  |  Cell Cycle

The molecular culprits underlying precocious mammary gland involution

Kate D Sutherland, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2007  |  Journal of Mammary Gland Biology and Neoplasia

Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation

Marie-Liesse Asselin-Labat, Kate D Sutherland, Holly Barker, Richard Thomas, Mark Shackleton, Natasha C Forrest, Lynne Hartley, Lorraine Robb, Frank G Grosveld, Jacqueline van der Wees, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2007  |  Nature Cell Biology

The emerging picture of the mouse mammary stem cell

Francois Vaillant, Marie-Liesse Asselin-Labat, Mark Shackleton, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2007  |  Stem Cell Reviews

c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3

Kate D Sutherland, Francois Vaillant, Warren S Alexander, Tim M Wintermantel, Natasha C Forrest, Sheridan L Holroyd, Edward J McManus, Gunther Schutz, Christine J Watson, Lewis A Chodosh, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2006  |  The EMBO Journal

Genetic services for men: The preferences of men with a family history of prostate cancer

Clara L Gaff, Ruth Cowan, Bettina Meiser, Geoffrey Lindeman

Journal article  |  2006  |  Genetics in Medicine

Genetic services for men: The preferences of men with a family history of prostate cancer

CL Gaff, R Cowan, B Meiser, G Lindeman

Journal article  |  2006  |  Genetics in Medicine

Characterization of the breast cancer associated ATM 7271T > G (V2424G) mutation by gene expression profiling

Nic Waddell, Jyoti Jonnalagadda, Anna Marsh, Scott Grist, Mark Jenkins, Karen Hobson, Malcolm Taylor, Geoff J Lindeman, Sean V Tavtigian, Graeme Suthers, David Goldgar, Peter J Oefner, Darrin Taylor, Sean Grimmond, Kum Kum Khanna, Georgia Chenevix-Trench

Journal article  |  2006  |  Genes, Chromosomes & Cancer

Mammary stem cells and mammopoiesis

Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2006  |  Cancer Research

Risk-reducing surgery, screening and chemoprevention practices of BRCA1 and BRCA2 mutation carriers: a prospective cohort study

K-A Phillips, MA Jenkins, GJ Lindeman, SA McLachlan, JM McKinley, PC Weideman, JL Hopper, ML Friedlander

Journal article  |  2006  |  Clinical Genetics

Steroid hormone receptor status of mouse mammary stem cells

Marie-Liesse Asselin-Labat, Mark Shackleton, John Stingl, Francois Vaillant, Natasha C Forrest, Connie J Eaves, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2006  |  JOURNAL OF THE NATIONAL CANCER INSTITUTE

Cancer risk management practices of non-carriers within BRCA1/2 mutation positive families in the Kathleen Cunningham Consortium for Research into Familial Breast Cancer (kConFab).

S Dawson, J McKinley, M Jenkins, S McLachlan, G Lindeman, M Friedlander, J Hopper, K Phillips

Conference Proceedings  |  2006  |  JOURNAL OF CLINICAL ONCOLOGY

Socs2 and Elf5 mediate prolactin-induced mammary gland development

J Harris, PM Stanford, K Sutherland, SR Oakes, MJ Naylor, FG Robertson, KD Blazek, M Kazlauskas, HN Hilton, S Wittlin, WS Alexander, GJ Lindeman, JE Visvader, CJ Ormandy

Journal article  |  2006  |  Molecular Endocrinology

CPAP interacts with 14-3-3 in a cell cycle-dependent manner

CY Chen, MA Olayioye, GJ Lindeman, TK Tang

Journal article  |  2006  |  Biochemical and Biophysical Research Communications

Shedding light on mammary stem cells and tumorigenesis

Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2006  |  Cell Cycle

Generation of a functional mammary gland from a single stem cell

M Shackleton, F Vaillant, KJ Simpson, J Stingl, GK Smyth, ML Asselin-Labat, L Wu, GJ Lindeman, JE Visvader

Journal article  |  2006  |  Nature

Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants

PK Lovelock, S Healey, W Au, EYM Sum, A Tesoriero, EM Wong, S Hinson, R Brinkworth, A Bekessy, O Diez, L Izatt, E Solomon, M Jenkins, H Renard, J Hopper, P Waring, SV Tavtigian, D Goldgar, GJ Lindeman, JE Visvader, et al.

Journal article  |  2006  |  Journal of Medical Genetics

Negative hormone receptor status of mouse mammary stem cells reminiscent of human basal breast tumors.

M-L Asselin-Labat, M Shackleton, J Stingl, F Vaillant, NC Forrest, CJ Eaves, JE Visvader, GJ Lindeman

Conference Proceedings  |  2006  |  BREAST CANCER RESEARCH AND TREATMENT

Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource

GJ Mann, H Thorne, RL Balleine, PN Butow, CL Clarke, E Edkins, GM Evans, S Fereday, E Haan, M Gattas, GG Giles, J Goldblatt, JL Hopper, J Kirk, JA Leary, G Lindeman, E Niedermayr, KA Phillips, S Picken, GM Pupo, et al.

Journal article  |  2006  |  Breast Cancer Research

Gene methylation in ductal fluid from BRCA1 and BRCA2 carriers as a predictor of breast cancer risk.

YC Antill, G Mitchell, SA Johnson, A Milner, L Devereux, A Sridhar, JA Kirk, G Lindeman, K-A Phillips, IG Campbell

Conference Proceedings  |  2006  |  BREAST CANCER RESEARCH AND TREATMENT

StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein

MA Olayioye, S Vehring, P Muller, A Herrmann, J Schiller, C Thiele, GJ Lindeman, JE Visvader, T Pomorski

Journal article  |  2005  |  Journal of Biological Chemistry

Loss of the LIM domain protein Lmo4 in the mammary gland during pregnancy impedes lobuloalveolar development

EYM Sum, M Shackleton, K Hahm, RM Thomas, LA O'Reilly, KU Wagner, GJ Lindeman, JE Visvader

Journal article  |  2005  |  Oncogene

Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer

EYM Sum, D Segara, B Duscio, ML Bath, AS Field, RL Sutherland, GJ Lindeman, JE Visvader

Journal article  |  2005  |  Proceedings of the National Academy of Sciences of the United States of America

The LIM domain protein Lmo4 is highly expressed in proliferating mouse epithelial tissues

EYM Sum, LA O'Reilly, N Jonas, GJ Lindeman, JE Visvader

Journal article  |  2005  |  Journal of Histochemistry and Cytochemistry

Breast cancer protein StarD10 identified by three-dimensional separation using free-flow electrophoresis, reversed-phase high-performance liquid chromatography, and sodium dodecyl sulfate polyacrylamide gel electrophoresis

P Hoffmann, MA Olayioye, RL Moritz, GJ Lindeman, JE Visvader, RJ Simpson, BE Kemp

Journal article  |  2005  |  Electrophoresis

Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation

J Zhou, R Chehab, J Tkalcevic, MJ Naylor, J Harris, TJ Wilson, S Tsao, I Tellis, S Zavarsek, DK Xu, EJ Lapinskas, J Visvader, GJ Lindeman, R Thomas, CJ Ormandy, PJ Hertzog, I Kola, MA Pritchard

Journal article  |  2005  |  EMBO Journal

Nipple aspiration and ductal lavage in women with a germline BRCA1 or BRCA2 mutation

G Mitchell, YC Antill, W Murray, J Kirk, E Salisbury, GJ Lindeman, J Di Iulio, AD Milner, L Devereaux, KA Phillips

Journal article  |  2005  |  Breast Cancer Research

XIAP-deficiency leads to delayed lobuloalveolar development in the mammary gland

MA Olayioye, H Kaufmann, M Pakusch, DL Vaux, GJ Lindeman, JE Visvader

Journal article  |  2005  |  Cell Death & Differentiation

A single mammary stem cell can reconstitute a functional mammary gland

M Shackleton, F Vaillant, KJ Simpson, J Singl, GK Smyth, L Wu, JE Visvader, GJ Lindeman

Conference Proceedings  |  2005  |  BREAST CANCER RESEARCH AND TREATMENT

Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer

AG Lewis, J Flanagan, A Marsh, GM Pupo, G Mann, AB Spurdle, GJ Lindeman, JE Visvader, MA Brown, G Chenevix-Trench

Journal article  |  2005  |  Breast Cancer Research

Predictors of participation in clinical and psychosocial follow-up of the kConFab breast cancer family cohort

KA Phillips, PN Butow, AE Stewart, JH Chang, PC Weideman, MA Price, SA McLachlan, GJ Lindeman, MJ McKay, ML Friedlander, JL Hopper

Journal article  |  2005  |  Familial Cancer

kConFab, Australian Ovarian Cancer Study & Familial Cancer Clinics of Australia and New Zealand: Series two of Kith and Kin

G Lindeman

Conference Proceedings  |  2004  |  Cancer Forum

Differential hypermethylation of SOCS genes in ovarian and breast carcinomas

KD Sutherland, GJ Lindeman, DYH Choong, S Wittlin, L Brentzell, W Phillips, IG Campbell, JE Visvader

Journal article  |  2004  |  Oncogene

MMTV-trBrca1 mice display strain-dependent abnormalities in vaginal development

KJ Simpson, MR Wati, AJ Deans, GJ Lindeman, MA Brown

Journal article  |  2004  |  International Journal of Developmental Biology

Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif

MJ Dubin, PH Stokes, EYM Sum, RS Williams, VA Valova, PJ Robinson, GJ Lindeman, JNM Glover, JE Visvader, JM Matthews

Journal article  |  2004  |  Journal of Biological Chemistry

Accuracy and completeness in reporting family history of prostate cancer by unaffected men

CL Gaff, C Aragona, RJ MacInnis, R Cowan, C Payne, GG Giles, GJ Lindeman

Journal article  |  2004  |  Urology

The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation

MA Olayioye, P Hoffmann, T Pomorski, J Armes, RJ Simpson, BE Kemp, GJ Lindeman, JE Visvader

Journal article  |  2004  |  Cancer Research

Complete radiological and metabolic response of metastatic renal cell carcinoma to SU5416 (semaxanib) in a patient with probable von Hippel-Lindau syndrome

RR Jennens, MA Rosenthal, GJ Lindeman, M Michael

Journal article  |  2004  |  Urologic Oncology - Seminars and Original Investigations

Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner deaf-1

KM Hahm, EYM Sum, Y Fujiwara, GJ Lindeman, JE Visvader, SH Orkin

Journal article  |  2004  |  Molecular and Cellular Biology

Familial cancer 2003 - research and practice, Couran Cove, Queensland, Australia, 3-6 September 2003.

Geoffrey J Lindeman

Journal article  |  2004  |  Familial Cancer

Frequency of the ATM IVS10-6T -> G variant in Australian multiple-case breast cancer families

GJ Lindeman, M Hiew, JE Visvader, J Leary, M Field, CL Gaff, RJM Gardner, K Trainor, G Cheetham, G Suthers, J Kirk

Journal article  |  2004  |  Breast Cancer Research

Ductal lavage in BRCA1/2 mutation-carriers: initial experience.

Y Antill, W Murray, G Lindeman, C House, G Phillips, G Mitchell

Conference Proceedings  |  2004  |  BREAST CANCER RESEARCH AND TREATMENT

MMTV-trBrca1 mice display strain-dependent abnormalities in vaginal development

Kaylene J Simpson

Journal article  |  2004  |  International Journal of Developmental Biology

Novel p53 germline mutation in a patient with Li-Fraumeni syndrome

SS Wong, G Lozano, CL Gaff, RJM Gardner, LC Strong, K Aittomaki, GJ Lindeman

Journal article  |  2003  |  Internal Medicine Journal

"Cancer in the family" and genetic testing: implications for life insurance

EL Lynch, RJ Doherty, CL Gaff, FA Macrae, GJ Lindeman

Journal article  |  2003  |  Medical Journal of Australia

Outclassing kath and kim an aussie kith and kin cancer conference: Meeting report on "Familial Cancer 2003 - Research and Practice", Couran Cove, Queensland, September 2003

G Lindeman

Conference Proceedings  |  2003  |  Cancer Forum

Identification of Taxreb 107 as a lactogenic hormone responsive gene in mammary epithelial cells

S Wittlin, KD Sutherland, JE Visvader, GJ Lindeman

Journal article  |  2003  |  Biochimica et Biophysica Acta-Gene Structure & Expression

Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas

KD Sutherland, JE Visvader, DYH Choong, EYM Sum, GJ Lindeman, IG Campbell

Journal article  |  2003  |  International Journal of Cancer

Two promoters within the human LMO4 gene contribute to its overexpression in breast cancer cells

S Wittlin, EYM Sum, NK Jonas, GJ Lindeman, JE Visvader

Journal article  |  2003  |  Genomics

Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins

MA Olayioye, MA Guthridge, FC Stomski, AF Lopez, JE Visvader, GJ Lindeman

Journal article  |  2003  |  Journal of Biological Chemistry

Transcriptional regulators in mammary gland development and cancer

JE Visvader, GJ Lindeman

Journal article  |  2003  |  International Journal of Biochemistry and Cell Biology

Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region

L Coultas, M Pellegrini, JE Visvader, GJ Lindeman, L Chen, JM Adams, DCS Huang, A Strasser

Journal article  |  2003  |  Cell Death & Differentiation

Investigation of the transcriptional changes underlying functional defects in the mammary glands of prolactin receptor knockout mice

CJ Ormandy, M Naylor, J Harris, F Robertson, ND Horseman, GJ Lindeman, J Visvader, PA Kelly

Journal article  |  2003  |  Recent Progress in Hormone Research

The LIM domain gene LMO4 is overexpressed in breast cancer and forms a complex with the tumor suppressor BRCA1

GJ Lindeman, B Peng, L O'Reilly, K Hahm, J Chen, J Armes, D Venter, JE Visvader, EY Sum, X Yu

Conference Proceedings  |  2002  |  BREAST CANCER RESEARCH AND TREATMENT

CPAP is a novel Stat5-interacting cofactor that augments Stat5-mediated transcriptional activity

B Peng, KD Sutherland, EYM Sum, M Olayioye, S Wittlin, TK Tang, GJ Lindeman, JE Visvader

Journal article  |  2002  |  Journal of Molecular Endocrinology

The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity

EYM Sum, B Peng, X Yu, JJ Chen, J Byrne, GJ Lindeman, JE Visvader

Journal article  |  2002  |  Journal of Biological Chemistry

Germline BRCA1 promoter deletions in UK and Australian familial breast cancer patients.

MA BROWN, LJ LO, A CATTEAU, CF XU, GJ LINDEMAN, S HODGSON, E SOLOMON

Journal article  |  2002  |  Human Mutation

Germline BRCA1 promoter deletions in UK and Australian familial breast cancer patients: Identification of a novel deletion consistent with BRCA1 :psi VBRCA1 recombination

MA Brown, LJ Lo, A Catteau, CF Xu, GJ Lindeman, S Hodgson, E Solomon

Journal article  |  2002  |  Human Mutation

The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer

JE Visvader, D Venter, K Hahm, M Santamaria, EYM Sum, L O'Reilly, D White, R Williams, J Armes, GJ Lindeman

Journal article  |  2001  |  Proceedings of the National Academy of Sciences of the United States of America

A single nucleotide polymorphism in the 5 ' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers

WW Wang, AB Spurdle, P Kolachana, B Bove, B Modan, SM Ebbers, G Suthers, MA Tucker, DJ Kaufman, MM Doody, RE Tarone, M Daly, H Levavi, H Pierce, A Chetrit, GH Yechezkel, G Chenevix-Trench, K Offit, AK Godwin, JP Struewing

Journal article  |  2001  |  Cancer Epidemiology, Biomarkers & Prevention

Design, production and characterization of FLIN2 and FLIN4: the engineering of intramolecular ldb1 : LMO complexes

JE Deane, E Sum, JP Mackay, GJ Lindeman, JE Visvader, JM Matthews

Journal article  |  2001  |  Protein Engineering

SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice

GJ Lindeman, S Wittlin, H Lada, MJ Naylor, M Santamaria, JG Zhang, R Starr, DJ Hilton, WS Alexander, CJ Ormandy, J Visvader

Journal article  |  2001  |  Genes & Development

E2F4 is exported from the nucleus in a CRM1-dependent manner

S Gaubatz, JA Lees, GJ Lindeman, DM Livingston

Journal article  |  2001  |  Molecular and Cellular Biology

E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control

S Gaubatz, GJ Lindeman, S Ishida, L Jakoi, JR Nevins, DM Livingston, RE Rempel

Journal article  |  2000  |  Molecular Cell

The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

LA O'Reilly, L Cullen, J Visvader, GJ Lindeman, C Print, ML Bath, DCS Huang, A Strasser

Journal article  |  2000  |  The American Journal of Pathology

11th Lorne Cancer Conference, Lorne, Victoria, Australia, 11-14th February 1999.

GJ Lindeman, JE Visvader

Journal article  |  1999  |  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting

GJ Lindeman, L Dagnino, S Gaubatz, YH Xu, RT Bronson, HB Warren, DM Livingston

Journal article  |  1998  |  Genes & Development

ANALYSIS OF HEMATOPOIESIS IN MAX-41 TRANSGENIC MICE THAT EXHIBIT SUSTAINED ELEVATIONS OF BLOOD GRANULOCYTES AND MONOCYTES

D METCALF, GJ LINDEMAN, NA NICOLA

Journal article  |  1995  |  Blood

OVEREXPRESSED MAX IS NOT ONCOGENIC AND ATTENUATES MYC-INDUCED LYMPHOPROLIFERATION AND LYMPHOMAGENESIS IN TRANSGENIC MICE

GJ LINDEMAN, AW HARRIS, ML BATH, RN EISENMAN, JM ADAMS

Journal article  |  1995  |  Oncogene

Contribution of the cyclin D1 gene to lymphomagenesis

JM ADAMS, BJ WARNER, SE BODRUG, ML BATH, GJ LINDEMAN, AW HARRIS

Conference Proceedings  |  1995  |  NORMAL AND MALIGNANT HEMATOPOIESIS

Cyclin D1 as the putative bcl-1 oncogene.

AW Harris, SE Bodrug, BJ Warner, ML Bath, GJ Lindeman, JM Adams

Journal article  |  1995  |  Current Topics in Microbiology and Immunology

B-LYMPHOID TO GRANULOCYTIC SWITCH DURING HEMATOPOIESIS IN A TRANSGENIC MOUSE STRAIN

GJ LINDEMAN, JM ADAMS, S CORY, AW HARRIS

Journal article  |  1994  |  Immunity

CYCLIN D1 TRANSGENE IMPEDES LYMPHOCYTE MATURATION AND COLLABORATES IN LYMPHOMAGENESIS WITH THE MYC GENE

SE BODRUG, BJ WARNER, ML BATH, GJ LINDEMAN, AW HARRIS, JM ADAMS

Journal article  |  1994  |  The EMBO Journal

MODELING HEMATOPOIETIC NEOPLASIA BY TRANSGENESIS

S CORY, AW HARRIS, A STRASSER, Y HAUPT, G LINDEMAN, M BATH, JM ADAMS

Journal article  |  1993  |  JOURNAL OF LEUKOCYTE BIOLOGY

INTRAVENOUS OR ORAL ADJUVANT CMF FOR NODE-POSITIVE BREAST-CANCER

GJ LINDEMAN, J BOYAGES, C DRIESSEN, AO LANGLANDS

Journal article  |  1992  |  ANZ Journal of Surgery

MALIGNANT FIBROUS HISTIOCYTOMA DEVELOPING IN BONE 44 YEARS AFTER SHRAPNEL TRAUMA

G LINDEMAN, MJ MCKAY, KL TAUBMAN, AM BILOUS

Journal article  |  1990  |  Cancer

Tuberculous meningitis in adults: practical comments on the diagnosis.

GJ Lindeman, S Naraqi

Journal article  |  1986  |  Papua and New Guinea Medical Journal