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Precision Genomic Medicine In Breast Cancer: Synergising Somatic And Germline Mutation Tes..
Evaluation of implementation of risk management guidelines for carriers of pathogenic vari..
Centre For Translational Breast Cancer Research (Transbcr): Delivering Laboratory Discover..
Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue rem..
Displaying the 15 most recent projects by Geoffrey Lindeman.
Displaying the 209 most recent scholarly works by Geoffrey Lindeman.
Predictors of long-term cancer-related distress among female BRCA1 and BRCA2 mutation carriers without a cancer diagnosis: an international analysis
Kelly A Metcalfe, Melanie A Price, Carol Mansfield, David C Hallett, Geoffrey J Lindeman, Angie Fairchild, Joshua Posner, Sue Friedman, Carrie Snyder, Henry T Lynch, D Gareth Evans, Steven A Narod, Alexander Liede
Journal article | 2020 | British Journal of Cancer
Evaluation of implementation of risk management guidelines for carriers of pathogenic variants in mismatch repair genes: a nationwide audit of familial cancer clinics
B Meiser, R Kaur, J Kirk, A Morrow, M Peate, WKT Wong, E McPike, E Cops, C Dowson, R Austin, M Fine, L Thrupp, R Ward, F Macrae, JE Hiller, AH Trainer, G Mitchell
Journal article | 2020 | Familial Cancer
INTRODUCTION: This nationwide study assessed the impact of Lynch syndrome-related risk management guidelines on clinicians' recomm..
Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling
Caleb A Dawson, Bhupinder Pal, Francois Vaillant, Luke C Gandolfo, Zhaoyuan Liu, Camille Bleriot, Florent Ginhoux, Gordon K Smyth, Geoffrey J Lindeman, Scott N Mueller, Anne C Rios, Jane E Visvader
Journal article | 2020 | Nature Cell Biology
Macrophages are diverse immune cells that reside in all tissues. Although macrophages have been implicated in mammary-gland functi..
Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids
Johanna F Dekkers, James R Whittle, Francois Vaillant, Huei-Rong Chen, Caleb Dawson, Kevin Liu, Maarten H Geurts, Marco J Herold, Hans Clevers, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2020 | JNCI: Journal of the National Cancer Institute
Breast cancer is characterized by histological and functional heterogeneity, posing a clinical challenge for patient treatment. Em..
Targeting triple-negative breast cancers with the Smac-mimetic birinapant
Najoua Lalaoui, Delphine Merino, Goknur Giner, Francois Vaillant, Diep Chau, Lin Liu, Tobias Kratina, Bhupinder Pal, James R Whittle, Nima Etemadi, Jean Berthelet, Julius Grasel, Cathrine Hall, Matthew E Ritchie, Matthias Ernst, Gordon K Smyth, David L Vaux, Jane E Visvader, Geoffrey J Lindeman, John Silke
Journal article | 2020 | Cell Death & Differentiation
Smac mimetics target inhibitor of apoptosis (IAP) proteins, thereby suppressing their function to facilitate tumor cell death. Her..
Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer.
James R Whittle, François Vaillant, Elliot Surgenor, Antonia N Policheni, Goknur Giner, Bianca D Capaldo, Huei-Rong Chen, He K Liu, Johanna F Dekkers, Norman Sachs, Hans Clevers, Andrew Fellowes, Thomas Green, Huiling Xu, Stephen B Fox, Marco J Herold, Gordon K Smyth, Daniel HD Gray, Jane E Visvader, Geoffrey J Lindeman
Journal article | 2020 | Clinical Cancer Research
PURPOSE: Although cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors significantly extend tumor response in patients with metasta..
STEM CELLS AND THE DIFFERENTIATION HIERARCHY IN MAMMARY GLAND DEVELOPMENT
Nai Yang Fu, Emma Nolan, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2020 | Physiological Reviews
The mammary gland is a highly dynamic organ that undergoes profound changes within its epithelium during puberty and the reproduct..
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes
Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R Barnes, Jamie Allen, Siddhartha Kar, Karen A Pooley, Joe Dennis, Kyriaki Michailidou, Constance Turman, Penny Soucy, Audrey Lemacon, Michael Lush, Jonathan P Tyrer, Maya Ghoussaini, Mahdi Moradi Marjaneh, Xia Jiang, Simona Agata, Kristiina Aittomaki, M Rosario Alonso, et al.
Journal article | 2020 | Nature Genetics
Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underl..
Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers
Elizabeth C Page, Elizabeth K Bancroft, Mark N Brook, Melissa Assel, Mona Hassan Al Battat, Sarah Thomas, Natalie Taylor, Anthony Chamberlain, Jennifer Pope, Holly Ni Raghallaigh, D Gareth Evans, Jeanette Rothwell, Lovise Maehle, Eli Marie Grindedal, Paul James, Lyon Mascarenhas, Joanne McKinley, Lucy Side, Tessy Thomas, Christi van Asperen, et al.
Journal article | 2019 | European Urology
BACKGROUND: Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluatin..
Development and validation of a targeted gene sequencing panel for application to disparate cancers
Mark J McCabe, Marie-Emilie A Gauthier, Chia-Ling Chan, Tanya J Thompson, Sunita MC De Sousa, Clare Puttick, John P Grady, Velimir Gayevskiy, Jiang Tao, Kevin Ying, Arcadi Cipponi, Niantao Deng, Alex Swarbrick, Melissa L Thomas, undefined kConFab, Reginald V Lord, Amber L Johns, Maija Kohonen-Corish, Sandra A O'Toole, Jonathan Clark, et al.
Journal article | 2019 | Scientific Reports
Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology ..
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca, Sandra Viz Lasheras, Roser Pujol, Johanna Kiiski, Taru A Muranen, Daniel R Barnes, Joe Dennis, Kyriaki Michailidou, Manjeet K Bolla, Goska Leslie, Cora M Aalfs, Muriel A Adank, Julian Adlard, Simona Agata, Karen Cadoo, Bjarni A Agnarsson, Thomas Ahearn, et al.
Journal article | 2019 | npj Breast Cancer
Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1..
Experiences and interpretations of BRCA1/2 testing among women affected by breast or ovarian cancer who received a negative result
Lesley Stafford, Alison Flehr, Fiona Judd, Geoffrey J Lindeman, Penny Gibson, Angela Komiti, G Bruce Mann, Maira Kentwell
Journal article | 2019 | Journal of Community Genetics
The aim of this study was to retrospectively describe the genetic testing motives and experiences of women with a previous breast ..
Iniparib administered weekly or twice-weekly in combination with gemcitabine/carboplatin in patients with metastatic triple-negative breast cancer: a phase II randomized open-label study with pharmacokinetics
Veronique Dieras, Herve Bonnefoi, Emilio Alba, Ahmad Awada, Bruno Coudert, Xavier Pivot, Joseph Gligorov, Agnes Jager, Stefania Zambelli, Geoffrey J Lindeman, Eric Charpentier, Gary T Emmons, Ignacio Garcia-Ribas, Robert Paridaens, Jaap Verweij
Journal article | 2019 | Breast Cancer Research and Treatment
PURPOSE: Metastatic triple-negative breast cancer (TNBC) is a phenotypic breast cancer subgroup with a very poor prognosis, despit..
Homologous recombination DNA repair defects in PALB2-associated breast cancers
Anqi Li, Felipe C Geyer, Pedro Blecua, Ju Youn Lee, Pier Selenica, David N Brown, Fresia Pareja, Simon SK Lee, Rahul Kumar, Barbara Rivera, Rui Bi, Salvatore Piscuoglio, Hannah Y Wen, John R Lozada, Rodrigo Gularte-Merida, Luca Cavallone, Zoulikha Rezoug, Tu Nguyen-Dumont, Paolo Peterlongo, Carlo Tondini, et al.
Journal article | 2019 | npj Breast Cancer
Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging.
Anne C Rios, Bianca D Capaldo, François Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, undefined 3DTCLSM Group, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2019 | Cancer Cell
Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging
Anne C Rios, Bianca D Capaldo, Francois Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader, Jamie R Flynn, William M Palmer, Antony P Martin, et al.
Journal article | 2019 | Cancer Cell
A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer
Sheau W Lok, James R Whittle, Francois Vaillant, Charis E Teh, Louisa L Lo, Antonia N Policheni, Alice RT Bergin, Jayesh Desai, Sarah Ftouni, Luke C Gandolfo, Danny Liew, He K Liu, G Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W Roberts, Mark A Rosenthal, Kylie Shackleton, Maria Joao Silva, et al.
Journal article | 2019 | Cancer Discovery
Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer
D Merino, TS Weber, A Serrano, F Vaillant, K Liu, B Pal, L Di Stefano, J Schreuder, D Lin, Y Chen, ML Asselin-Labat, TN Schumacher, D Cameron, GK Smyth, AT Papenfuss, GJ Lindeman, JE Visvader, SH Naik
Journal article | 2019 | Nature Communications
Tailored NEOadjuvant epirubicin, cyclophosphamide and Nanoparticle Albumin-Bound paclitaxel for breast cancer: The phase II NEONAB trial-Clinical outcomes and molecular determinants of response
Caitlin Murphy, Andrea Muscat, David Ashley, Violet Mukaro, Linda West, Yang Liao, David Chisanga, Wei Shi, Ian Collins, Sally Baron-Hay, Sujata Patil, Geoffrey Lindeman, Mustafa Khasraw
Journal article | 2019 | PloS one
Phase 1 trial of olaparib and oral cyclophosphamide in BRCA breast cancer, recurrent BRCA ovarian cancer, non-BRCA triple-negative breast cancer, and non-BRCA ovarian cancer
Chee Khoon Lee, Clare Scott, Geoffrey J Lindeman, Anne Hamilton, Elizabeth Lieschke, Emma Gibbs, Rebecca Asher, Heath Badger, Robin Paterson, Lauren Macnab, Edmond Michael Kwan, Prudence A Francis, Frances Boyle, Michael Friedlander
Journal article | 2019 | British Journal of Cancer
Psychosocial impact of undergoing prostate cancer screening for men with BRCA1 or BRCA2 mutations
Elizabeth K Bancroft, Sibel Saya, Elizabeth C Page, Kathryn Myhill, Sarah Thomas, Jennifer Pope, Anthony Chamberlain, Rachel Hart, Wayne Glover, Jackie Cook, Derek J Rosario, Brian T Helfand, Christina Hutten Selkirk, Rosemarie Davidson, Mark Longmuir, Diana M Eccles, Neus Gadea, Carole Brewer, Julian Barwell, Monica Salinas, et al.
Journal article | 2019 | BJU International
Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer
Stefano Annunziato, Julian R de Ruiter, Linda Henneman, Chiara S Brambillasca, Catrin Lutz, Francois Vaillant, Federica Ferrante, Anne Paulien Drenth, Eline van der Burg, Bjorn Siteur, Bas van Gerwen, Roebi de Bruijn, Martine H van Miltenburg, Ivo J Huijbers, Marieke van de Ven, Jane E Visvader, Geoffrey J Lindeman, Lodewyk FA Wessels, Jos Jonkers
Journal article | 2019 | Nature Communications
Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence
Nai Yang Fu, Bhupinder Pal, Yunshun Chen, Felicity C Jackling, Michael Milevskiy, Francois Vaillant, Bianca D Capaldo, Fusheng Guo, Kevin H Liu, Anne C Rios, Nicholas Lim, Andrew J Kueh, David M Virshup, Marco J Herold, Haley O Tucker, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2018 | Developmental Cell
Frequent activating STAT3 mutations and novel recurrent genomic abnormalities detected in breast implant-associated anaplastic large cell lymphoma.
Piers Blombery, Ella Thompson, Georgina L Ryland, Rachel Joyce, David J Byrne, Christine Khoo, Stephen Lade, Mark Hertzberg, Greg Hapgood, Paula Marlton, Anand Deva, Geoffrey Lindeman, Stephen Fox, David Westerman, Miles Prince
Journal article | 2018 | Oncotarget
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare form of T-cell lymphoma that occurs after implantati..
Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids
Ewa M Michalak, Michael JG Milevskiy, Rachel M Joyce, Johanna F Dekkers, Paul R Jamieson, Bhupinder Pal, Caleb A Dawson, Yifang Hu, Stuart H Orkin, Warren S Alexander, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Journal article | 2018 | PLOS Biology
D-BEYOND: A window of opportunity trial evaluating denosumab, a RANK-ligand (RANKL) inhibitor and its biological effects in young pre-menopausal women diagnosed with early breast cancer
Bastien Nguyen, Marion Maetens, Roberto Salgado, David Venet, Peter Vuylsteke, Laura Polastro, Hans Wieldiers, Philippe Simon, Geoff Lindeman, Denis Larsimont, Gert Van den Eynden, Chloe Velghe, Francoise Rothe, Soizic Garaud, Stefan Michiels, Karen Willard-gallo, Hatem A Azim, Sherene Loi, Martine Piccart, Christos Sotiriou
Conference Proceedings | 2018 | Clinical Trials
Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition
Christos Mikropoulos, Christina G Hutten Selkirk, Sibel Saya, Elizabeth Bancroft, Emily Vertosick, Tokhir Dadaev, Charles Brendler, Elizabeth Page, Alexander Dias, D Gareth Evans, Jeanette Rothwell, Lovise Maehle, Karol Axcrona, Kate Richardson, Diana Eccles, Thomas Jensen, Palle J Osther, Christi J van Asperen, Hans Vasen, Lambertus A Kiemeney, et al.
Journal article | 2018 | British Journal of Cancer
Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling
Bhupinder Pal, Yunshun Chen, Francois Vaillant, Paul Jamieson, Lavinia Gordon, Anne C Rios, Stephen Wilcox, Naiyang Fu, Kevin He Liu, Felicity C Jackling, Melissa J Davis, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Journal article | 2017 | Nature Communications
Preferences for breast cancer risk reduction among BRCA1/BRCA2 mutation carriers: a discrete-choice experiment
Alexander Liede, Carol A Mansfield, Kelly A Metcalfe, Melanie A Price, Carrie Snyder, Henry T Lynch, Sue Friedman, Justyna Amelio, Joshua Posner, Steven A Narod, Geoffrey J Lindeman, D Gareth Evans
Journal article | 2017 | Breast Cancer Research and Treatment
Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer
Delphine Merino, James R Whittle, Francois Vaillant, Antonin Serrano, Jia-Nan Gong, Goknur Giner, Ana Leticia Maragno, Maia Chanrion, Emilie Schneider, Bhupinder Pal, Xiang Li, Grant Dewson, Julius Grasel, Kevin Liu, Najoua Lalaoui, David Segal, Marco J Herold, David CS Huang, Gordon K Smyth, Olivier Geneste, et al.
Journal article | 2017 | Science Translational Medicine
Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer
Emma Nolan, Peter Savas, Antonia N Policheni, Phillip K Darcy, Francois Vaillant, Christopher P Mintoff, Sathana Dushyanthen, Mariam Mansour, Jia-Min B Pang, Stephen B Fox, Charles M Perou, Jane E Visvader, Daniel HD Gray, Sherene Loi, Geoffrey J Lindeman
Journal article | 2017 | Science translational medicine
Safety and efficacy of the BCL2 inhibitor venetoclax in estrogen receptor (ER) and BCL2-positive metastatic breast cancer: The mBEP study.
Geoffrey John Lindeman, Sheau Wen Lok, Alice Ruth Bergin, James Richard Whittle, Kylie Shackleton, Peter Sherman, Sarah-Jane Dawson, Jayesh Desai, Danny Liew, Bruce Mann, Anand Murugasu, Andrew Warwick Roberts, Mark Rosenthal, Jane Visvader
Conference Proceedings | 2017 | Journal of Clinical Oncology
Mainstreaming cancer genetics: A model integrating germline BRCA testing into routine ovarian cancer clinics
Maira Kentwell, Eryn Dow, Yoland Antill, C David Wrede, Orla McNally, Emily Higgs, Anne Hamilton, Sumitra Ananda, Geoffrey J Lindeman, Clare L Scott
Journal article | 2017 | Gynecologic Oncology
New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells
Carmel M O'Brien, Hun S Chy, Qi Zhou, Shiri Blumenfeld, Jack W Lambshead, Xiaodong Liu, Joshua Kie, Bianca D Capaldo, Tung-Liang Chung, Timothy E Adams, Phan Tram, John D Bentley, William J McKinstry, Karen Oliva, Paul J McMurrick, Yu-Chieh Wang, Fernando J Rossello, Geoffrey J Lindeman, Di Chen, Thierry Jarde, et al.
Journal article | 2017 | STEM CELLS
Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive
Nai Yang Fu, Anne C Rios, Bhupinder Pal, Charity W Law, Paul Jamieson, Ruijie Liu, Francois Vaillant, Felicity Jackling, Kevin He Liu, Gordon K Smyth, Geoffrey J Lindeman, Matthew E Ritchie, Jane E Visvader
Journal article | 2017 | Nature Cell Biology
RANK ligand as a target for breast cancer prevention in BRCA1 mutation carriers
GJ Lindeman, E Nolan, F Vaillant, D Branstetter, B Pal, G Giner, L Whitehead, SW Lok, GB Mann, K Rohrbach, L-Y Huang, R Soriano, GK Smyth, WC Dougall, JE Visvader
Conference Proceedings | 2017 | General Session Abstracts
Patient-derived xenograft (PDX) models in basic and translational breast cancer research
Lacey E Dobrolecki, Susie D Airhart, Denis G Alferez, Samuel Aparicio, Fariba Behbod, Mohamed Bentires-Alj, Cathrin Brisken, Carol J Bult, Shirong Cai, Robert B Clarke, Heidi Dowst, Matthew J Ellis, Eva Gonzalez-Suarez, Richard D Iggo, Peter Kabos, Shunqiang Li, Geoffrey J Lindeman, Elisabetta Marangoni, Aaron McCoy, Funda Meric-Bernstam, et al.
Journal article | 2016 | Cancer and Metastasis Reviews
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
Kate Lawrenson, Siddhartha Kar, Karen McCue, Karoline Kuchenbaeker, Kyriaki Michailidou, Jonathan Tyrer, Jonathan Beesley, Susan J Ramus, Qiyuan Li, Melissa K Delgado, Janet M Lee, Kristiina Aittomaki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Banu K Arun, Brita Arver, Elisa V Bandera, Monica Barile, Rosa B Barkardottir, et al.
Journal article | 2016 | NATURE COMMUNICATIONS
RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers
Emma Nolan, Francois Vaillant, Daniel Branstetter, Bhupinder Pal, Goeknur Giner, Lachlan Whitehead, Sheau W Lok, Gregory B Mann, Kathy Rohrbach, Li-Ya Huang, Rosalia Soriano, Gordon K Smyth, William C Dougall, Jane E Visvader, Geoffrey J Lindeman
Journal article | 2016 | Nature Medicine
Integration of microRNA signatures of distinct mammary epithelial cell types with their gene expression and epigenetic portraits
Bhupinder Pal, Yunshun Chen, Andrew Bert, Yifang Hu, Julie M Sheridan, Tamara Beck, Wei Shi, Keith Satterley, Paul Jamieson, Gregory J Goodall, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Journal article | 2015 | Breast Cancer Research
Large genomic rearrangements in the familial breast and ovarian cancer gene BRCA1 are associated with an increased frequency of high risk features
Paul A James, Sarah Sawyer, Samantha Boyle, Mary-Anne Young, Serguei Kovalenko, Rebecca Doherty, Joanne McKinley, Kathryn Alsop, Victoria Beshay, Marion Harris, Stephen Fox, Geoffrey J Lindeman, Gillian Mitchell
Journal article | 2015 | Familial Cancer
A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1
Julie M Sheridan, Matthew E Ritchie, Sarah A Best, Kun Jiang, Tamara J Beck, Francois Vaillant, Kevin Liu, Ross A Dickins, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2015 | BMC Cancer
EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival
Nai Yang Fu, Anne C Rios, Bhupinder Pal, Rina Soetanto, Aaron TL Lun, Kevin Liu, Tamara Beck, Sarah A Best, Francois Vaillant, Philippe Bouillet, Andreas Strasser, Thomas Preiss, Gordon K Smyth, Rey J Lindeman, Jane E Visvader
Journal article | 2015 | Nature Cell Biology
Patient-derived xenograft models of breast cancer and their predictive power.
James R Whittle, Michael T Lewis, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2015 | Breast cancer research : BCR
Despite advances in the treatment of patients with early and metastatic breast cancer, mortality remains high due to intrinsic or ..
Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study
Elizabeth K Bancroft, Elizabeth C Page, Elena Castro, Hans Lilja, Andrew Vickers, Daniel Sjoberg, Melissa Assel, Christopher S Foster, Gillian Mitchell, Kate Drew, Lovise Maehle, Karol Axcrona, D Gareth Evans, Barbara Bulman, Diana Eccles, Donna McBride, Christi van Asperen, Hans Vasen, Lambertus A Kiemeney, Janneke Ringelberg, et al.
Journal article | 2014 | European Urology
Breast-Cancer Risk in Families with Mutations in PALB2
AC Antoniou, S Casadei, T Heikkinen, D Barrowdale, K Pylkaes, J Roberts, A Lee, D Subramanian, K De Leeneer, F Fostira, E Tomiak, SL Neuhausen, ZL Teo, S Khan, K Aittomaeki, JS Moilanen, C Turnbull, S Seal, A Mannermaa, A Kallioniemi, et al.
Journal article | 2014 | New England Journal of Medicine
The incidence of PALB2 c.3113G > A in women with a strong family history of breast and ovarian cancer attending familial cancer centres in Australia
Zhi L Teo, Sarah D Sawyer, Paul A James, Gillian Mitchell, Alison H Trainer, Geoffrey J Lindeman, Kylie Shackleton, Linda Cicciarelli, Melissa C Southey
Journal article | 2013 | FAMILIAL CANCER
Distinct nuclear receptor expression in stroma adjacent to breast tumors
Kevin C Knower, Ashwini L Chand, Natalie Eriksson, Kiyoshi Takagi, Yasuhiro Miki, Hironobu Sasano, Jane E Visvader, Geoffrey J Lindeman, John W Funder, Peter J Fuller, Evan R Simpson, Wayne D Tilley, Peter J Leedman, J Dinny Graham, George EO Muscat, Christine L Clarke, Colin D Clyne
Journal article | 2013 | BREAST CANCER RESEARCH AND TREATMENT
Tumour morphology predicts PALB2 germline mutation status
ZL Teo, E Provenzano, GS Dite, DJ Park, C Apicella, SD Sawyer, PA James, G Mitchell, AH Trainer, GJ Lindeman, K Shackleton, L Cicciarelli, SS Buys, IL Andrulis, AM Mulligan, G Glendon, EM John, MB Terry, M Daly, FA Odefrey, et al.
Journal article | 2013 | BRITISH JOURNAL OF CANCER
Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer
Francois Vaillant, Delphine Merino, Lily Lee, Kelsey Breslin, Bhupinder Pal, Matthew E Ritchie, Gordon K Smyth, Michael Christie, Louisa J Phillipson, Christopher J Burns, G Bruce Mann, Jane E Visvader, Geoffrey J Lindeman
Journal article | 2013 | Cancer Cell
Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetically high risk men
Emma Killick, Richard Morgan, Francesca Launchbury, Elizabeth Bancroft, Elizabeth Page, Elena Castro, Zsofia Kote-Jarai, Armen Aprikian, Ignacio Blanco, Virginia Clowes, Susan Domchek, Fiona Douglas, Diana Eccles, D Gareth Evans, Marion Harris, Judy Kirk, Jimmy Lam, Geoffrey Lindeman, Gillian Mitchell, Nicholas Pachter, et al.
Journal article | 2013 | Scientific Reports
Global Changes in the Mammary Epigenome Are Induced by Hormonal Cues and Coordinated by Ezh2
Bhupinder Pal, Toula Bouras, Wei Shi, Francois Vaillant, Julie M Sheridan, Naiyang Fu, Kelsey Breslin, Kun Jiang, Matthew E Ritchie, Matthew Young, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Journal article | 2013 | Cell Reports
Phase I trial of the oral PARP inhibitor olaparib in combination with paclitaxel for first-or second-line treatment of patients with metastatic triple-negative breast cancer
Rebecca A Dent, Geoffrey J Lindeman, Mark Clemons, Hans Wildiers, Arlene Chan, Nicole J McCarthy, Christian F Singer, Elizabeth S Lowe, Claire L Watkins, James Carmichael
Journal article | 2013 | Breast Cancer Research
A Role for Common Genomic Variants in the Assessment of Familial Breast Cancer
Sarah Sawyer, Gillian Mitchell, Joanne McKinley, Georgia Chenevix-Trench, Jonathan Beesley, Xiao Qing Chen, David Bowtell, Alison H Trainer, Marion Harris, Geoffrey J Lindeman, Paul A James
Journal article | 2012 | JOURNAL OF CLINICAL ONCOLOGY
Isolation of Mouse Mammary Epithelial Subpopulations: A Comparison of Leading Methods
Matthew J Smalley, Howard Kendrick, Julie M Sheridan, Joseph L Regan, Michael D Prater, Geoffrey J Lindeman, Christine J Watson, Jane E Visvader, John Stingl
Journal article | 2012 | Journal of Mammary Gland Biology and Neoplasia
Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737
Samantha R Oakes, Francois Vaillant, Elgene Lim, Lily Lee, Kelsey Breslin, Frank Feleppa, Siddhartha Deb, Matthew E Ritchie, Elena Takano, Teresa Ward, Stephen B Fox, Daniele Generali, Gordon K Smyth, Andreas Strasser, David CS Huang, Jane E Visvader, Geoffrey J Lindeman
Journal article | 2012 | Proceedings of the National Academy of Sciences of the United States of America
Analysis of RAD51C Germline Mutations in High-Risk Breast and Ovarian Cancer Families and Ovarian Cancer Patients
Ella R Thompson, Samantha E Boyle, Julie Johnson, Georgina L Ryland, Sarah Sawyer, David YH Choong, Georgia Chenevix-Trench, Alison H Trainer, Geoffrey J Lindeman, Gillian Mitchell, Paul A James, Ian G Campbell
Journal article | 2012 | Human Mutation
Challenges to the Development of New Agents for Molecularly Defined Patient Subsets: Lessons From BRCA1/2-Associated Breast Cancer
Susan M Domchek, Gillian Mitchell, Geoffrey J Lindeman, Nadine M Tung, Judith Balmana, Steven J Isakoff, Rita Schmutzler, M William Audeh, Niklas Loman, Clare Scott, Michael Friedlander, Bella Kaufman, Judy E Garber, Andrew Tutt, Mark E Robson
Journal article | 2011 | Journal of Clinical Oncology
Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14
Marie-Liesse Asselin-Labat, Kate D Sutherland, Francois Vaillant, David E Gyorki, Di Wu, Sheridan Holroyd, Kelsey Breslin, Teresa Ward, Wei Shi, Mary L Bath, Siddhartha Deb, Stephen B Fox, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2011 | Molecular and Cellular Biology
Proteomic profiling of secretome and adherent plasma membranes from distinct mammary epithelial cell subpopulations
Hong Ji, Robert JA Goode, Francois Vaillant, Suresh Mathivanan, Eugene A Kapp, Rommel A Mathias, Geoffrey J Lindeman, Jane E Visvader, Richard J Simpson
Journal article | 2011 | Proteomics
An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
Philip A Gregory, Cameron P Bracken, Eric Smith, Andrew G Bert, Josephine A Wright, Suraya Roslan, Melanie Morris, Leila Wyatt, Gelareh Farshid, Yat-Yuen Lim, Geoffrey J Lindeman, M Frances Shannon, Paul A Drew, Yeesim Khew-Goodall, Gregory J Goodall
Journal article | 2011 | Molecular Biology of the Cell
Mammary stem cells and their regulation by steroid hormones.
Marie-Liesse Asselin-Labat, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2011 | Expert Review of Endocrinology & Metabolism
Sustained exposure to estrogen and progesterone is a well-established risk factor for breast cancer. These hormones play a central..
Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit
CE Smart, A Wronski, JD French, SL Edwards, M-L Asselin-Labat, N Waddell, K Peters, BL Brewster, K Brooks, K Simpson, N Manning, SR Lakhani, S Grimmond, GJ Lindeman, JE Visvader, MA Brown
Journal article | 2011 | Oncogene
LMO4 expression in squamous cell carcinoma of the anterior tongue
Rhonda A Kwong, Christopher J Scarlett, Larry H Kalish, Ian E Cole, James G Kench, Eleanor YM Sum, Elizabeth A Musgrove, Susan M Henshall, Geoffrey J Lindeman, Andrew V Biankin, Jane E Visvader, Robert L Sutherland
Journal article | 2011 | Histopathology
Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study
Anita V Mitra, Elizabeth K Bancroft, Yolanda Barbachano, Elizabeth C Page, CS Foster, C Jameson, G Mitchell, GJ Lindeman, A Stapleton, G Suthers, DG Evans, D Cruger, I Blanco, C Mercer, J Kirk, L Maehle, S Hodgson, L Walker, L Izatt, F Douglas, et al.
Journal article | 2011 | British Journal of Urology
The rs10993994 Risk Allele for Prostate Cancer Results in Clinically Relevant Changes in Microseminoprotein-Beta Expression in Tissue and Urine
Hayley C Whitaker, Zsofia Kote-Jarai, Helen Ross-Adams, Anne Y Warren, Johanna Burge, Anne George, Elizabeth Bancroft, Sameer Jhavar, Daniel Leongamornlert, Malgorzata Tymrakiewicz, Edward Saunders, Elizabeth Page, Anita Mitra, Gillian Mitchell, Geoffrey J Lindeman, D Gareth Evans, Ignacio Blanco, Catherine Mercer, Wendy S Rubinstein, Virginia Clowes, et al.
Journal article | 2010 | PLoS ONE
Loss of STARD 10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status
Niamh C Murphy, Andrew V Biankin, Ewan KA Millar, Catriona M McNeil, Sandra A O'Toole, Davendra Segara, Paul Crea, Monilola A Olayioye, C Soon Lee, Stephen B Fox, Adrienne L Morey, Michael Christie, Elizabeth A Musgrove, Roger J Daly, Geoffrey J Lindeman, Susan M Henshall, Jane E Visvader, Robert L Sutherland
Journal article | 2010 | International Journal of Cancer
Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors
Jeremy M Arnold, David YH Choong, Ella R Thompson, Nic Waddell, Geoffrey J Lindeman, Jane E Visvader, Ian G Campbell, Georgia Chenevix-Trench
Journal article | 2010 | Breast Cancer Research and Treatment
Gene Methylation in Breast Ductal Fluid from BRCA1 and BRCA2 Mutation Carriers
Yoland C Antill, Gillian Mitchell, Sandra A Johnson, Lisa Devereux, Alvin Milner, Juliana Di Iuiio, Geoffrey J Lindeman, Judy Kirk, Kelly Anne Phillips, Ian G Campbell
Journal article | 2010 | Cancer Epidemiology, Biomarkers & Prevention
Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
Elgene Lim, Di Wu, Bhupinder Pal, Toula Bouras, Marie-Liesse Asselin-Labat, Francois Vaillant, Hideo Yagita, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Journal article | 2010 | Breast Cancer Research
Lineage Enforcement by Inductive Mesenchyme on Adult Epithelial Stem Cells across Developmental Germ Layers
Renea A Taylor, Hong Wang, Sarah E Wilkinson, Michelle G Richards, Kara L Britt, Francois Vaillant, Geoffrey J Lindeman, Jane E Visvader, Gerald R Cunha, Justin St John, Gail P Risbridger
Journal article | 2009 | Stem Cells
Expression of S100A2 Calcium-Binding Protein Predicts Response to Pancreatectomy for Pancreatic Cancer
Andrew V Biankin, James G Kench, Emily K Colvin, Davendra Segara, Christopher J Scarlett, Nam Q Nguyen, David K Chang, Adrienne L Morey, C-Soon Lee, Mark Pinese, Samuel CL Kuo, Johana M Susanto, Peter H Cosman, Geoffrey J Lindeman, Jane E Visvader, Tuan V Nguyen, Neil D Merrett, Janindra Warusavitarne, Elizabeth A Musgrove, Susan M Henshall, et al.
Journal article | 2009 | Gastroenterology
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
Elgene Lim, Francois Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen, Frank Feleppa, Lily I Huschtscha, Heather J Thorne, Stephen B Fox, Max Yan, Juliet D French, Melissa A Brown, Gordon K Smyth, Jane E Visvader, Geoffrey J Lindeman
Journal article | 2009 | Nature Medicine
Predictors of the use of complementary and alternative medicine (CAM) by women at high risk for breast cancer
KM Field, MA Jenkins, ML Friedlander, JM McKinley, MA Price, P Weideman, LA Keogh, SA McLachlan, GJ Lindeman, JL Hopper, PN Butow, KA Phillips
Journal article | 2009 | European Journal of Cancer
The Ets transcription factor Elf5 specifies mammary alveolar cell fate
Samantha R Oakes, Matthew J Naylor, Marie-Liesse Asselin-Labat, Katrina D Blazek, Margaret Gardiner-Garden, Heidi N Hilton, Michael Kazlauskas, Melanie A Pritchard, Lewis A Chodosh, Peter L Pfeffer, Geoffrey J Lindeman, Jane E Visvader, Christopher J Ormandy
Journal article | 2008 | Genes & Development
Cancer risk management practices of noncarriers within BRCA1/2 mutation - Positive families in the Kathleen Cuningham Foundation Consortium for Research into Familial Breast cancer
Sarah-Jane Dawson, Melanie A Price, Mark A Jenkins, Joanne M McKinley, Phyllis N Butow, Sue-Anne McLachlan, Geoffrey J Lindeman, Prue Weideman, Michael L Friedlander, John L Hopper, Kelly-Anne Phillips
Journal article | 2008 | Journal of Clinical Oncology
Elucidating the stem and progenitor cell hierarchy in breast development and cancer - an essential role for GATA-3
GJ Lindeman, Asselin-Labal M-L, KD Sutherland, H Barker, R Thomas, M Shackleton, L Hartley, L Robb, FG Grosveld, der Wees J van, JE Visvader
Conference Proceedings | 2007 | BREAST CANCER RESEARCH AND TREATMENT
Effects of a treatment gap during adjuvant chemotherapy in node-positive breast cancer: results of International Breast Cancer Study Group (IBCSG) Trials 13-93 and 14-93
Marco Colleoni, Shari Gelber, Edda Simoncini, Olivia Pagani, Richard D Gelber, Karen N Price, Monica Castiglione-Gertsch, Alan S Coates, Aron Goldhirsch, A Goldhirsch, AS Coates, B Thuerlimann, M Castiglione, AS Coates, JP Collins, H Cortes Funes, RD Gelber, A Goldhirsch, M Green, A Hiltbrunner, et al.
Journal article | 2007 | Annals of Oncology
Genome-wide association study identifies novel breast cancer susceptibility loci
Douglas F Easton, Karen A Pooley, Alison M Dunning, Paul DP Pharoah, Deborah Thompson, Dennis G Ballinger, Jeffery P Struewing, Jonathan Morrison, Helen Field, Robert Luben, Nicholas Wareham, Shahana Ahmed, Catherine S Healey, Richard Bowman, Kerstin B Meyer, Christopher A Haiman, Laurence K Kolonel, Brian E Henderson, Loic Le Marchand, Paul Brennan, et al.
Journal article | 2007 | Nature
Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
Marie-Liesse Asselin-Labat, Kate D Sutherland, Holly Barker, Richard Thomas, Mark Shackleton, Natasha C Forrest, Lynne Hartley, Lorraine Robb, Frank G Grosveld, Jacqueline van der Wees, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2007 | Nature Cell Biology
c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3
Kate D Sutherland, Francois Vaillant, Warren S Alexander, Tim M Wintermantel, Natasha C Forrest, Sheridan L Holroyd, Edward J McManus, Gunther Schutz, Christine J Watson, Lewis A Chodosh, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2006 | The EMBO Journal
Characterization of the breast cancer associated ATM 7271T > G (V2424G) mutation by gene expression profiling
Nic Waddell, Jyoti Jonnalagadda, Anna Marsh, Scott Grist, Mark Jenkins, Karen Hobson, Malcolm Taylor, Geoff J Lindeman, Sean V Tavtigian, Graeme Suthers, David Goldgar, Peter J Oefner, Darrin Taylor, Sean Grimmond, Kum Kum Khanna, Georgia Chenevix-Trench
Journal article | 2006 | Genes, Chromosomes & Cancer
Cancer risk management practices of non-carriers within BRCA1/2 mutation positive families in the Kathleen Cunningham Consortium for Research into Familial Breast Cancer (kConFab).
S Dawson, J McKinley, M Jenkins, S McLachlan, G Lindeman, M Friedlander, J Hopper, K Phillips
Conference Proceedings | 2006 | JOURNAL OF CLINICAL ONCOLOGY
Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants
PK Lovelock, S Healey, W Au, EYM Sum, A Tesoriero, EM Wong, S Hinson, R Brinkworth, A Bekessy, O Diez, L Izatt, E Solomon, M Jenkins, H Renard, J Hopper, P Waring, SV Tavtigian, D Goldgar, GJ Lindeman, JE Visvader, et al.
Journal article | 2006 | Journal of Medical Genetics
Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource
GJ Mann, H Thorne, RL Balleine, PN Butow, CL Clarke, E Edkins, GM Evans, S Fereday, E Haan, M Gattas, GG Giles, J Goldblatt, JL Hopper, J Kirk, JA Leary, G Lindeman, E Niedermayr, KA Phillips, S Picken, GM Pupo, et al.
Journal article | 2006 | BREAST CANCER RESEARCH
Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer
EYM Sum, D Segara, B Duscio, ML Bath, AS Field, RL Sutherland, GJ Lindeman, JE Visvader
Journal article | 2005 | Proceedings of the National Academy of Sciences of the United States of America
Breast cancer protein StarD10 identified by three-dimensional separation using free-flow electrophoresis, reversed-phase high-performance liquid chromatography, and sodium dodecyl sulfate polyacrylamide gel electrophoresis
P Hoffmann, MA Olayioye, RL Moritz, GJ Lindeman, JE Visvader, RJ Simpson, BE Kemp
Journal article | 2005 | Electrophoresis
Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation
J Zhou, R Chehab, J Tkalcevic, MJ Naylor, J Harris, TJ Wilson, S Tsao, I Tellis, S Zavarsek, DK Xu, EJ Lapinskas, J Visvader, GJ Lindeman, R Thomas, CJ Ormandy, PJ Hertzog, I Kola, MA Pritchard
Journal article | 2005 | EMBO Journal
The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer
JE Visvader, D Venter, K Hahm, M Santamaria, EYM Sum, L O'Reilly, D White, R Williams, J Armes, GJ Lindeman
Journal article | 2001 | Proceedings of the National Academy of Sciences of the United States of America
A single nucleotide polymorphism in the 5 ' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers
WW Wang, AB Spurdle, P Kolachana, B Bove, B Modan, SM Ebbers, G Suthers, MA Tucker, DJ Kaufman, MM Doody, RE Tarone, M Daly, H Levavi, H Pierce, A Chetrit, GH Yechezkel, G Chenevix-Trench, K Offit, AK Godwin, JP Struewing
Journal article | 2001 | Cancer Epidemiology, Biomarkers & Prevention
Displaying the most recent news article by Geoffrey Lindeman.
Honours, Awards and Fellowships
NHMRC Leadership Fellowship 3
Victoria Prize for Science and Innovation (Life Sciences) (Jointly with Jane Visvader)
Ramaciotti Medal for Excellence in Biomedical Research (Jointly with Jane Visvader)
Senior Principal Research Fellowship
Medical Oncology Group of Australia - Novartis Oncology Cancer Achievement Award
The Robert Sutherland Award for Excellence in Translational Research
FAA - Fellow of the Australian Academy of Science
FAHMS - Fellow of the Australian Academy of Health and Medical Sciences
FRACP - Fellow of the Royal Australasian College of Physicians
Medicine - Royal Melbourne Hospital
Bachelor of Medicine and Surgery
University of Sydney
Bachelor of Medical Science
University of Sydney
Doctor of Philosophy
University of Melbourne