Ian van Driel is a Professor in the Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne. He completed his undergraduate studies at the University of Western Australia before embarking upon a PhD at the Walter and Eliza Hall Institute in Melbourne.
After three years as a research fellow in Dallas, Texas, USA he returned to Australia in 1989 to take up a position at Monash University, Melbourne and moved to the University of Melbourne in 2001. He now heads a research laboratory at the Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne working on immune responses to pathogenic bacteria in the lung and gut, inflammatory bowel disease, and autoimmune disease. Professor van Driel's work currently focusses on investigating the immune response to pathogenic bacteria, particularly pathogenic E coli and L. pneumophila. This work seeks to better define the roles of immune cells and molecules that combat bacteria in the tissues in which they colonise, namely; the gut and lung. Professor van Driel has also made a number of fundamental contributions to the understanding of autoimmune disease and immunological tolerance particularly in the area of autoimmunity of the stomach (autoimmune gastritis and pernicious anaemia).
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Mechanisms Used By Plasmacytoid Dendritic Cells To Combat Bacterial Infections
Internal Research Grant
Application of a chemical probe to detect neutrophil elastase activation during inflammato..
Displaying the 21 most recent projects by Ian van Driel.
Internal Research Grant
Displaying the 126 most recent scholarly works by Ian van Driel.
Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease
Bethany M Anderson, Daniel P Poole, Luigi Aurelio, Garrett Z Ng, Markus Fleischmann, Paulina Kasperkiewicz, Celine Morissette, Marcin Drag, Ian R van Driel, Brian L Schmidt, Stephen J Vanner, Nigel W Bunnett, Laura E Edgington-Mitchell
Journal article | 2019 | Scientific Reports
The Mouse as a Model for Pulmonary Legionella Infection.
Garrett Z Ng, Anastasia Solomatina, Ian R van Driel, Elizabeth L Hartland
Book Chapter | 2019 | Methods in Molecular Biology
Infection of C57BL/6 mice with wild-type Legionella pneumophila typically results in very mild disease. However, in mice where the..
Investigating the roles of IFN gamma and IFN gamma-stimulated GTPases during Legionella pneumophila replication in alveolar macrophages and monocyte-derived cells
Chao Yang, Shivani Pasricha, Sze Ying Ong, Andrew Stephen Brown, Junya Yamagishi, Chihiro Sugimoto, Sammy Bedoui, Ian R van Driel, Elizabeth L Hartland
Conference Proceedings | 2017 | CYTOKINE
IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid
Jan Naujoks, Christoph Tabeling, Brian D Dill, Christine Hoffmann, Andrew S Brown, Mareike Kunze, Stefan Kempa, Andrea Peter, Hans-Joachim Mollenkopf, Anca Dorhoi, Olivia Kershaw, Achim D Gruber, Leif E Sander, Martin Witzenrath, Susanne Herold, Andreas Nerlich, Andreas C Hocke, Ian van Driel, Norbert Suttorp, Sammy Bedoui, et al.
Journal article | 2016 | PLOS Pathogens
Transient Systemic Inflammation Does Not Alter the Induction of Tolerance to Gastric Autoantigens by Migratory Dendritic Cells
Dorothee Bourges, Ellen M Ross, Stacey Allen, Simon Read, Fiona J Houghton, Sammy Bedoui, Louis Boon, Paul A Gleeson, Ian R van Driel
Journal article | 2014 | Journal of Immunology
Independent trafficking of the KCNQ1 K channel and H -K -ATPase in gastric parietal cells from mice
Nguyen Nhung, Noga Kozer-Gorevich, Briony L Gliddon, Adam J Smolka, Andrew H Clayton, Paul A Gleeson, Ian R van Driel
Journal article | 2013 | American Journal of Physiology - Gastrointestinal and Liver Physiology
A method for quantifying pulmonary Legionella pneumophila infection in mouse lungs by flow cytometry.
Desmond Koon Yong Ang, Sze Ying Ong, Andrew Stephen Brown, Elizabeth Louise Hartland, Ian Richard van Driel
Journal article | 2012 | BMC Research Notes
BACKGROUND: Pulmonary load of Legionella pneumophila in mice is normally determined by counting serial dilutions of bacterial colo..
Random mutagenesis of the mouse genome: a strategy for discovering gene function and the molecular basis of disease
Nguyen Nhung, Louise M Judd, Anastasia Kalantzis, Belinda Whittle, Andrew S Giraud, Ian R van Driel
Journal article | 2011 | American Journal of Physiology - Gastrointestinal and Liver Physiology
Cutting Edge: Pulmonary Legionella pneumophila Is Controlled by Plasmacytoid Dendritic Cells but Not Type I IFN
Desmond KY Ang, Clare VL Oates, Ralf Schuelein, Michelle Kel Ly, Fiona M Sansom, Dorothee Bourges, Louis Boon, Paul J Hertzog, Elizabeth L Hartland, Ian R van Driel
Journal article | 2010 | Journal of Immunology
Loss of RegI in conjunction with gastrin deficiency in mice facilitates efficient gastric ulcer healing but is dispensable for hyperplasia and tumourigenesis
Anthony J Peterson, Nhung Nguyen, Hiroshi Okamoto, Andrew S Giraud, Ian R van Driel, Louise M Judd
Journal article | 2010 | Regulatory Peptides
The Interleukin-6 Family Cytokine Interleukin-11 Regulates Homeostatic Epithelial Cell Turnover and Promotes Gastric Tumor Development
Meegan Howlett, Andrew S Giraud, Helen Lescesen, Cameron B Jackson, Anastasia Kalantzis, Ian R Van Driel, Lorraine Robb, Mark Van der Hoek, Matthias Ernst, Toshinari Minamoto, Alex Boussioutas, Hiroko Oshima, Masanobu Oshima, Louise M Judd
Journal article | 2009 | Gastroenterology
Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis.
Ian R van Driel, Alan G Baxter, Karen L Laurie, Tricia D Zwar, Nicole L La Gruta, Louise M Judd, Katrina L Scarff, Pablo A Silveira, Paul A Gleeson
Journal article | 2002 | Autoimmunity Reviews
Over the past 10 years experimental autoimmune gastritis has been established as a highly defined model of organ-specific autoimmu..
Regulation of gastric epithelial cell development revealed in H /K -ATPase beta-subunit- and gastrin-deficient mice
TV Franic, LM Judd, D Robinson, SP Barrett, KL Scarff, PA Gleeson, LC Samuelson, IR Van Driel
Journal article | 2001 | American Journal of Physiology - Gastrointestinal and Liver Physiology
Inhibition of rat colon tumors by sulindac and sulindac sulfone is independent of K-ras (codon 12) mutation.
TA de Jong, SA Skinner, C Malcontenti-Wilson, D Vogiagis, M Bailey, IR van Driel, PE O'Brien
Journal article | 2000 | American Journal of Physiology-Gastrointestinal and Liver Physiology
Nonsteroidal anti-inflammatory drug (NSAID) use reduces the risk of colorectal cancer by 40-50%. Previous studies suggest that eff..
Autoimmune gastritis results in disruption of gastric epithelial cell development.
LM Judd, PA Gleeson, BH Toh, IR van Driel
Journal article | 1999 | American Journal of Physiology-Gastrointestinal and Liver Physiology
We have investigated the underlying basis of the lesion in murine autoimmune gastritis, a model of the human disease pernicious an..
Renal expression of the gene encoding the gastric H( )-K( )-ATPase beta-subunit.
JM Callaghan, SS Tan, MA Khan, KA Curran, WG Campbell, AJ Smolka, BH Toh, PA Gleeson, CS Wingo, BD Cain
Journal article | 1995 | American Journal of Physiology-Renal Physiology
The gastric mucosal parietal cells and cells of the renal collecting duct both possess H(+)-K(+)-adenosinetriphosphatase (H(+)-K(+..
FAST FREEZE-FIXATION FREEZE-SUBSTITUTION REVEALS THE SECRETORY MEMBRANES OF THE GASTRIC PARIETAL-CELL AS A NETWORK OF HELICALLY COILED TUBULE - A NEW MODEL FOR PARIETAL-CELL TRANSFORMATION
JM PETTITT, DC HUMPHRIS, SP BARRETT, BH TOH, IR VANDRIEL, PA GLEESON
Journal article | 1995 | Journal of Cell Science
First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2 and monoclonal antibodies, but not lipoproteins.
IR van Driel, JL Goldstein, TC Südhof, MS Brown
Journal article | 1987 | Journal of Biological Chemistry
The ligand binding domain of the low density lipoprotein receptor consists of seven cysteine-rich repeats of approximately 40 amin..
USE OF MICROBORE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY FOR PURIFYING SUBNANOMOLE LEVELS OF POLYPEPTIDES FOR MICROSEQUENCING - STRUCTURAL STUDIES ON THE MURINE PLASMA-CELL ANTIGEN PC-1
B GREGO, IR VANDRIEL, JW GODING, EC NICE, RJ SIMPSON
Journal article | 1986 | International Journal of Peptide and Protein Research
A MICROBORE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY STRATEGY FOR THE PURIFICATION OF POLYPEPTIDES FOR GAS-PHASE SEQUENCE-ANALYSIS - STRUCTURAL STUDIES ON THE MURINE TRANSFERRIN RECEPTOR
B GREGO, IR VANDRIEL, PA STEARNE, JW GODING, EC NICE, RJ SIMPSON
Journal article | 1985 | European Journal of Biochemistry
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Head Of School-Biomedical Sciences
School Of Biomedical Sciences
Australasian Society for Biochemistry and Molecular Biology
American Society for Cell Biology
American Physiological Society
Australasian Society for Immunology
Doctor of Philosophy
University of Melbourne
Bachelor of Science (Honours)
The University of Western Australia