Padma Murthi

The Placental NLRP3 Inflammasome and Its Downstream Targets, Caspase-1 and Interleukin-6, Are Increased in Human Fetal Growth Restriction: Implications for Aberrant Inflammation-Induced Trophoblast Dysfunction

Irvan Alfian, Amlan Chakraborty, Hannah EJ Yong, Sheetal Saini, Ricky WK Lau, Bill Kalionis, Evdokia Dimitriadis, Nadia Alfaidy, Sharon D Ricardo, Chrishan S Samuel, Padma Murthi

Journal article  |  2022  |  CELLS

Fetal growth restriction (FGR) is commonly associated with placental insufficiency and inflammation. Nonetheless, the role played ..

Proteoglycans: Systems-Level Insight into Their Expression in Healthy and Diseased Placentas

Orsolya Oravecz, Andrea Balogh, Roberto Romero, Yi Xu, Kata Juhasz, Zsolt Gelencser, Zhonghui Xu, Gaurav Bhatti, Roger Pique-Regi, Balint Peterfia, Petronella Hupuczi, Ilona Kovalszky, Padma Murthi, Adi L Tarca, Zoltan Papp, Janos Matko, Nandor Gabor Than

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteoglycan macromolecules play key roles in several physiological processes (e.g., adhesion, proliferation, migration, invasion,..

A Novel Approach to Enhance the Regenerative Potential of Circulating Endothelial Progenitor Cells in Patients with End-Stage Kidney Disease

Amrilmaen Badawi, Osfred C Jefferson, Brooke M Huuskes, Sharon D Ricardo, Peter G Kerr, Chrishan S Samuel, Padma Murthi

Journal article  |  2022  |  BIOMEDICINES

Circulating bone marrow-derived endothelial progenitor cells (EPCs) facilitate vascular repair in several organs including the kid..

Role of NLRP7 in Normal and Malignant Trophoblast Cells.

Roland Abi Nahed, Maya Elkhoury Mikhael, Deborah Reynaud, Constance Collet, Nicolas Lemaitre, Thierry Michy, Pascale Hoffmann, Frederic Sergent, Christel Marquette, Padma Murthi, Tiphaine Raia-Barjat, Nadia Alfaidy, Mohamed Benharouga

Journal article  |  2022  |  Biomedicines

Gestational choriocarcinoma (CC) is an aggressive cancer that develops upon the occurrence of abnormal pregnancies such as Hydatid..

Significance of the placental barrier in antenatal viral infections

Hannah EJ Yong, Shiao-Yng Chan, Amlan Chakraborty, Gayathri Rajaraman, Sharon Ricardo, Mohamed Benharouga, Nadia Alfaidy, Frantisek Staud, Padma Murthi

Journal article  |  2021  |  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The placenta provides a significant physical and physiological barrier to prevent fetal infection during pregnancy. Nevertheless, ..

HIV in pregnancy: Mother-to-child transmission, pharmacotherapy, and toxicity

Lukas Cerveny, Padma Murthi, Frantisek Staud

Journal article  |  2021  |  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

An estimated 1.3 million pregnant women were living with HIV in 2018. HIV infection is associated with adverse pregnancy outcomes ..

NLRP7 Promotes Choriocarcinoma Growth and Progression through the Establishment of an Immunosuppressive Microenvironment

Deborah Reynaud, Roland Abi Nahed, Nicolas Lemaitre, Pierre-Adrien Bolze, Wael Traboulsi, Frederic Sergent, Christophe Battail, Odile Filhol, Vincent Sapin, Houssine Boufettal, Pascale Hoffmann, Touria Aboussaouira, Padma Murthi, Rima Slim, Mohamed Benharouga, Nadia Alfaidy

Journal article  |  2021  |  CANCERS

The inflammatory gene NLRP7 is the major gene responsible for recurrent complete hydatidiform moles (CHM), an abnormal pregnancy t..

Evidence-Based View of Safety and Effectiveness of Prokineticin Receptors Antagonists during Pregnancy

Deborah Reynaud, Frederic Sergent, Roland Abi Nahed, Wael Traboulsi, Constance Collet, Christel Marquette, Pascale Hoffmann, Gianfranco Balboni, Qun-Yong Zhou, Padma Murthi, Mohamed Benharouga, Nadia Alfaidy

Journal article  |  2021  |  BIOMEDICINES

Endocrine gland derived vascular endothelial growth factor (EG-VEGF) is a canonical member of the prokineticin (PROKs) family. It ..

Combining mesenchymal stem cells with serelaxin provides enhanced renoprotection against 1K/DOCA/salt-induced hypertension

Yifang Li, Matthew Shen, Dorota Ferens, Brad RS Broughton, Padma Murthi, Sheetal Saini, Robert E Widdop, Sharon D Ricardo, Anita A Pinar, Chrishan S Samuel

Journal article  |  2021  |  BRITISH JOURNAL OF PHARMACOLOGY

BACKGROUND AND PURPOSE: Fibrosis is a hallmark of chronic kidney disease (CKD) that significantly contributes to renal dysfunction..

The placenta is the villain or victim in the pathogenesis of pre-eclampsia: FOR: The placenta is the villain in the pathogenesis of preeclampsia

P Murthi, SP Brennecke

Journal article  |  2021  |  BJOG: an International Journal of Obstetrics and Gynaecology