Padma Murthi

Placental serotonin systems in pregnancy metabolic complications associated with maternal obesity and gestational diabetes mellitus (Retraction of Vol 1866, art no 65391, 2020)

Padma Murthi, Cathy Vaillancourt

Journal article  |  2021  |  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Combining mesenchymal stem cells with serelaxin provides enhanced renoprotection against 1K/DOCA/salt-induced hypertension

Yifang Li, Matthew Shen, Dorota Ferens, Brad RS Broughton, Padma Murthi, Sheetal Saini, Robert E Widdop, Sharon D Ricardo, Anita A Pinar, Chrishan S Samuel

Journal article  |  2021  |  British Journal of Pharmacology

BACKGROUND AND PURPOSE: Fibrosis is a hallmark of chronic kidney disease (CKD) that significantly contributes to renal dysfunction..

Inflammasomes in the Pathophysiology of Maternal Obesity: Potential Therapeutic Targets to Reduce Long-Term Adverse Health Outcomes in the Mother and Offspring

Padma Murthi, Gayathri Rajaraman

Journal article  |  2021  |  Current Vascular Pharmacology

Over the past 20 years, the prevalence of obesity has risen dramatically worldwide, with an increase in occurrence among women in ..

The Emerging Role of the Prokineticins and Homeobox Genes in the Vascularization of the Placenta: Physiological and Pathological Aspects

Nadia Alfaidy, Sophie Brouillet, Gayathri Rajaraman, Bill Kalionis, Pascale Hoffmann, Tiphaine Barjat, Mohamed Benharouga, Padma Murthi

Journal article  |  2020  |  Frontiers in Physiology

Vasculogenesis and angiogenesis are key processes of placental development, which occur throughout pregnancy. Placental vasculogen..

The placenta is the villain or victim in the pathogenesis of pre-eclampsia

P Murthi, SP Brennecke

Journal article  |  2020  |  BJOG An International Journal of Obstetrics & Gynaecology

Decidual mesenchymal stem/stromal cell-derived extracellular vesicles ameliorate endothelial cell proliferation, inflammation, and oxidative stress in a cell culture model of preeclampsia

Shixuan Zheng, Aiwu Shi, Sophia Hill, Claire Grant, Maria I Kokkinos, Padma Murthi, Harry M Georgiou, Shaun P Brennecke, Bill Kalionis

Journal article  |  2020  |  Pregnancy Hypertension

Oxidative stress and endothelial dysfunction contribute substantially to the pathogenesis of preeclampsia (PE). Decidual mesenchym..

Hydroxychloroquine Mitigates the Production of 8-Isoprostane and Improves Vascular Dysfunction: Implications for Treating Preeclampsia

Rahana Abd Rahman, Padma Murthi, Harmeet Singh, Seshini Gurungsinghe, Bryan Leaw, Joanne C Mockler, Rebecca Lim, Euan M Wallace

Journal article  |  2020  |  International Journal of Molecular Sciences

In preeclampsia, widespread maternal endothelial dysfunction is often secondary to excessive generation of placental-derived anti-..

Decreased Placental FPR2 in Early Pregnancies That Later Developed Small-For-Gestation Age: A Potential Role of FPR2 in the Regulation of Epithelial-Mesenchymal Transition

Padma Murthi, Gayathri Rajaraman, Jan Jaap HM Erwich, Evdokia Dimitriadis

Journal article  |  2020  |  Cells

We reported earlier that an anti-inflammatory small peptide receptor-formyl peptide receptor-2 (FPR2) was significantly decreased ..

The Effects of Early-Onset Pre-Eclampsia on Placental Creatine Metabolism in the Third Trimester

Stacey J Ellery, Padma Murthi, Paul A Della Gatta, Anthony K May, Miranda L Davies-Tuck, Greg M Kowalski, Damien L Callahan, Clinton R Bruce, Euan M Wallace, David W Walker, Hayley Dickinson, Rod J Snow

Journal article  |  2020  |  International Journal of Molecular Sciences

Creatine is a metabolite important for cellular energy homeostasis as it provides spatio-temporal adenosine triphosphate (ATP) buf..

Placental serotonin systems in pregnancy metabolic complications associated with maternal obesity and gestational diabetes mellitus

Padma Murthi, Cathy Vaillancourt

Journal article  |  2020  |  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Serotonin (5-hydroxytryptamine, 5-HT) regulates diverse physiological and behavioural and processes, also acts as a developmental ..