Frances Separovic

Chemical Exchange of Hydroxyl Groups in Lipidic Cubic Phases Characterized by NMR.

Thomas G Meikle, David W Keizer, Jeffrey J Babon, Calum J Drummond, Frances Separovic, Charlotte E Conn, Shenggen Yao

Journal article  |  2021  |  The Journal of Physical Chemistry B

Proton transportation in proximity to the lipid bilayer membrane surface, where chemical exchange represents a primary pathway, is..

How do Self-Assembling Antimicrobial Lipopeptides Kill Bacteria?

Haoning Gong, Marc-Antoine Sani, Xuzhi Hu, Ke Fa, Jack William Hart, Mingrui Liao, Peter Hollowell, Jessica Carter, Luke A Clifton, Mario Campana, Peixun Li, Stephen M King, John RP Webster, Armando Maestro, Shiying Zhu, Frances Separovic, Thomas A Waigh, Hai Xu, Andrew J McBain, Jian Ren Lu

Journal article  |  2020  |  ACS Applied Materials & Interfaces

Antimicrobial peptides are promising alternatives to traditional antibiotics. A group of self-assembling lipopeptides was formed b..

NMR Chemical Shift and Methylation of 4-Nitroimidazole: Experiment and Theory

Frederick Backler, Marc Antoine Sani, Frances Separovic, Vladislav Vasilyev, Feng Wang

Journal article  |  2020  |  Australian Journal of Chemistry

Nitroimidazoles and derivatives are a class of active pharmaceutical ingredients (APIs) first introduced sixty years ago. As anti-..

The Location of the Antimicrobial Peptide Maculatin 1.1 in Model Bacterial Membranes

Anton P Le Brun, Shiying Zhu, Marc-Antoine Sani, Frances Separovic

Journal article  |  2020  |  Frontiers in Chemistry

Physiochemical Characterization and Stability of Lipidic Cubic Phases by Solution NMR

Thomas G Meikle, David W Keizer, Jeffrey J Babon, Calum J Drummond, Frances Separovic, Charlotte E Conn, Shenggen Yao

Journal article  |  2020  |  Langmuir

Lipidic inverse bicontinuous cubic phases (LCPs), formed via the spontaneous self-assembly of lipids such as monoolein, have found..

A multifunctional surfactant catalyst inspired by hydrolases

Mitchell D Nothling, Zeyun Xiao, Nicholas S Hill, Mitchell T Blyth, Ayana Bhaskaran, Marc-Antoine Sani, Andrea Espinosa-Gomez, Kevin Ngov, Jonathan White, Tim Buscher, Frances Separovic, Megan L O'Mara, Michelle L Coote, Luke A Connal

Journal article  |  2020  |  Science Advances

The remarkable power of enzymes to undertake catalysis frequently stems from their grouping of multiple, complementary chemical un..

In-Cell Structure Determination of an Antimicrobial Peptide by DNP Solid-State NMR

Shiying Zhu, Frances Separovic, Marc Antoine Sani

Conference Proceedings  |  2020  |  BIOPHYSICAL JOURNAL

Solid-State NMR Study of Live Bacteria in the Presence of Antimicrobial Agents

Shiying Zhu, Sarah A Overall, Vinzenz Hofferek, Frances Separovic, Marc-Antoine Sani

Conference Proceedings  |  2020  |  BIOPHYSICAL JOURNAL

The Conformations of Virginiamycin M-1 Diacetate, an Inhibitor of Guinea Pig Brain CCK-B Receptors, in Selected Solvents

Kevin Walsworth, Anastasiya Bender, Frances Separovic, B Mikael Bergdahl, Robert P Metzger

Journal article  |  2020  |  Australian Journal of Chemistry

The Virginiamycin M1 derivative Virginiamycin-14,16-diacetate (VM1-diAc) is not naturally occurring and must be synthesised by tho..

In-Cell Solid-State NMR Analysis of Membrane Proteins

S Zhu, MA Sani, F Separovic

Journal article  |  2020  |  Australian Journal of Chemistry