Frances Separovic

Utilizing magnetic resonance techniques to study membrane interactions of amyloid peptides

Sunnia Rajput, Marc-Antoine Sani, David W Keizer, Frances Separovic

Journal article  |  2021  |  BIOCHEMICAL SOCIETY TRANSACTIONS

Alzheimer's disease (AD) is a common neurodegenerative condition that involves the extracellular accumulation of amyloid plaques p..

Polarization Transfer to External Nuclear Spins Using Ensembles of Nitrogen-Vacancy Centers

AJ Healey, LT Hall, GAL White, T Teraji, M-A Sani, F Separovic, J-P Tetienne, LCL Hollenberg

Journal article  |  2021  |  PHYSICAL REVIEW APPLIED

The nitrogen-vacancy (N-V) center in diamond has emerged as a candidate to noninvasively hyperpolarize nuclear spins in molecular ..

C-terminus amidation influences biological activity and membrane interaction of maculatin 1.1

Shiying Zhu, Wenyi Li, Neil O'Brien-Simpson, Frances Separovic, Marc-Antoine Sani

Conference Proceedings  |  2021  |  AMINO ACIDS

Cationic antimicrobial peptides have been investigated for their potential use in combating infections by targeting the cell membr..

Chemically modified and conjugated antimicrobial peptides against superbugs

Wenyi Li, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

Journal article  |  2021  |  CHEMICAL SOCIETY REVIEWS

Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050, will lead to more deaths from bacteri..

Structural Disruptions of the Outer Membranes of Gram-Negative Bacteria by Rationally Designed Amphiphilic Antimicrobial Peptides

Haoning Gong, Xuzhi Hu, Mingrui Liao, Ke Fa, Daniela Ciumac, Luke A Clifton, Marc-Antoine Sani, Stephen M King, Armando Maestro, Frances Separovic, Thomas A Waigh, Hai Xu, Andrew J McBain, Jian Ren Lu

Journal article  |  2021  |  ACS APPLIED MATERIALS & INTERFACES

Gram-negative bacteria are covered by both an inner cytoplasmic membrane (IM) and an outer membrane (OM). Antimicrobial peptides (..

Chemical Exchange of Hydroxyl Groups in Lipidic Cubic Phases Characterized by NMR

Thomas G Meikle, David W Keizer, Jeffrey J Babon, Calum J Drummond, Frances Separovic, Charlotte E Conn, Shenggen Yao

Journal article  |  2021  |  JOURNAL OF PHYSICAL CHEMISTRY B

Proton transportation in proximity to the lipid bilayer membrane surface, where chemical exchange represents a primary pathway, is..

Prospects for nuclear spin hyperpolarization of molecular samples using nitrogen-vacancy centers in diamond

J-P Tetienne, LT Hall, AJ Healey, GAL White, M-A Sani, F Separovic, LCL Hollenberg

Journal article  |  2021  |  PHYSICAL REVIEW B

After initial proof-of-principle demonstrations, optically pumped nitrogen-vacancy (NV) centers in diamond have been proposed as a..

In-Cell Solid-State NMR Analysis of Membrane Proteins

Shiying Zhu, Marc-Antoine Sani, Frances Separovic

Journal article  |  2021  |  AUSTRALIAN JOURNAL OF CHEMISTRY

Solid-state NMR spectroscopy (ssNMR) has great potential to provide atomistic detail of membrane proteins (MPs) as it is suitable ..

How do Self-Assembling Antimicrobial Lipopeptides Kill Bacteria?

Haoning Gong, Marc-Antoine Sani, Xuzhi Hu, Ke Fa, Jack William Hart, Mingrui Liao, Peter Hollowell, Jessica Carter, Luke A Clifton, Mario Campana, Peixun Li, Stephen M King, John RP Webster, Armando Maestro, Shiying Zhu, Frances Separovic, Thomas A Waigh, Hai Xu, Andrew J McBain, Jian Ren Lu

Journal article  |  2020  |  ACS Applied Materials and Interfaces

Antimicrobial peptides are promising alternatives to traditional antibiotics. A group of self-assembling lipopeptides was formed b..

(Re)Defining the Proline-Rich Antimicrobial Peptide Family and the Identification of Putative New Members

Nicholas G Welch, Wenyi Li, Mohammed Akhter Hossain, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

Journal article  |  2020  |  FRONTIERS IN CHEMISTRY

As we rapidly approach a post-antibiotic era in which multi-drug resistant bacteria are ever-pervasive, antimicrobial peptides (AM..