Frances Separovic

The role of bacterial lipid diversity and membrane properties in modulating antimicrobial peptide activity and drug resistance

Tzong-Hsien Lee, Vinzenz Hofferek, Frances Separovic, Gavin E Reid, Marie-Isabel Aguilar

Journal article  |  2019  |  Current Opinion in Chemical Biology

This review provides an analysis of the role that membrane composition and structure plays in the resistance of microorganisms to ..

Heteronuclear NMR spectroscopy of proteins encapsulated in cubic phase lipids

Thomas G Meikle, Ashish Sethi, David W Keizer, Jeffrey J Babon, Frances Separovic, Paul R Gooley, Charlotte E Conn, Shenggen Yao

Journal article  |  2019  |  Journal of Magnetic Resonance

Cholesterol-Dependent Cytolysins: Membrane and Protein Structural Requirements for Pore Formation

Craig J Morton, Marc-Antoine Sani, Michael W Parker, Frances Separovic

Journal article  |  2019  |  Chemical Reviews

The cholesterol-dependent cytolysins (CDCs) are a family of bacterial protein toxins specifically targeting eukaryotic cells throu..

Membrane biophysics session.

Pingsheng Liu, Frances Separovic

Journal article  |  2019  |  Biophysical Reviews

Biophysics & Structural Biology at Synchrotrons BSBS 2019 Biological NMR Session.

Frances Separovic

Journal article  |  2019  |  Biophysical Reviews

Metallo-Cubosomes: Zinc-Functionalized Cubic Nanoparticles for Therapeutic Nucleotide Delivery

Behnoosh Tajik-Ahmadabad, Lucas Chollet, Jacinta White, Frances Separovic, Anastasios Polyzos

Journal article  |  2019  |  Molecular Pharmaceutics

Combating bacterial resistance by combination of antibiotics with antimicrobial peptides

Dean E Sheard, Neil M O'Brien-Simpson, John D Wade, Frances Separovic

Journal article  |  2019  |  Pure and Applied Chemistry

In Situ Monitoring of Bacteria under Antimicrobial Stress Using P-31 Solid-State NMR

Sarah A Overall, Shiying Zhu, Eric Hanssen, Frances Separovic, Marc-Antoine Sani

Journal article  |  2019  |  International Journal of Molecular Sciences

Measuring translational diffusion of N-15-enriched biomolecules in complex solutions with a simplified H-1-N-15 HMQC-filtered BEST sequence

Shenggen Yao, Thomas G Meikle, Ashish Sethi, Frances Separovic, Jeffrey J Babon, David W Keizer

Journal article  |  2018  |  European Biophysics Journal

ListeriolysinO Binding Affects Cholesterol and Phospholipid Acyl Chain Dynamics in Fluid Cholesterol-Rich Bilayers

Mirijam Kozorog, Marc-Antoine Sani, Frances Separovic, Gregor Anderluh

Journal article  |  2018  |  Chemistry – A European Journal

Aggregation kinetics in the presence of brain lipids of A beta(1-40) cleaved from a soluble fusion protein

Miriam A Kael, Daniel K Weber, Frances Separovic, Marc-Antoine Sani

Journal article  |  2018  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Fluorescence imaging of the interaction of amyloid beta 40 peptides with live cells and model membrane

Elaheh Jamasbi, Mohammed Akhter Hossain, Marsha Tan, Frances Separovic, Giuseppe D Ciccotosto

Journal article  |  2018  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Effect of dimerized melittin on gastric cancer cells and antibacterial activity

Elaheh Jamasbi, Sasidharan S Lucky, Wenyi Li, Mohammed Akhter Hossain, Ponnampalam Gopalakrishnakone, Frances Separovic

Journal article  |  2018  |  Amino Acids

Elucidating the bactericidal mechanism of action of the linear antimicrobial tetrapeptide BRBR-NH2

Qiu Ying Lau, Jianguo Li, Marc-Antoine Sani, Sheetal Sinha, Yan Li, Fui Mee Ng, CongBao Kang, Surajit Bhattacharjya, Frances Separovic, Chandra Verma, Cheng San Brian Chia

Journal article  |  2018  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Interaction of N-terminal peptide analogues of the Na ,K -ATPase with membranes

Nguyen Khoa, Alvaro Garcia, Marc-Antoine Sani, Dil Diaz, Vikas Dubey, Daniel Clayton, Giovanni Dal Poggetto, Flemming Cornelius, Richard J Payne, Frances Separovic, Himanshu Khandelia, Ronald J Clarke

Journal article  |  2018  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Stability and activity of lysozyme in stoichiometric and non-stoichiometric protic ionic liquid (PIL)-water systems

Emmy C Wijaya, Frances Separovic, Calum J Drummond, Tamar L Greaves

Journal article  |  2018  |  The Journal of Chemical Physics

F-19 NMR studies provide insights into lipid membrane interactions of listeriolysin O, a pore forming toxin from Listeria monocytogenes

Mirijam Kozorog, Marc-Antoine Sani, Martina Lenarcic Zivkovic, Gregor Ilc, Vesna Hodnik, Frances Separovic, Janez Plavec, Gregor Anderluh

Journal article  |  2018  |  Scientific Reports

Covalent conjugation of cationic antimicrobial peptides with a beta-lactam antibiotic core

Wenyi Li, Neil M O'Brien-Simpson, James A Holden, Laszlo Otvos, Eric C Reynolds, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Journal article  |  2018  |  Peptide Science

Interaction of cationic antimicrobial peptides from Australian frogs with lipid membranes

Shiying Zhu, Marc-Antoine Sani, Frances Separovic

Journal article  |  2018  |  Peptide Science

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

Tony Velkov, Alejandra Gallardo-Godoy, James D Swarbrick, Mark AT Blaskovich, Alysha G Elliott, Meiling Han, Philip E Thompson, Kade D Roberts, Johnny X Huang, Bernd Becker, Mark S Butler, Lawrence H Lash, Sonia Troeira Henriques, Roger L Nation, Sivashangarie Sivanesan, Marc-Antoine Sani, Frances Separovic, Haydyn Mertens, Dieter Bulach, Torsten Seemann, et al.

Journal article  |  2018  |  Cell Chemical Biology

Effect of phosphatidylcholine bilayer thickness and molecular order on the binding of the antimicrobial peptide maculatin 1.1

Tzong-Hsien Lee, Marc-Antoine Sani, Sarah Overall, Frances Separovic, Marie-Isabel Aguilar

Journal article  |  2018  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Antimicrobial Peptide Structures: From Model Membranes to Live Cells

Marc-Antoine Sani, Frances Separovic

Journal article  |  2018  |  Chemistry - A European Journal

Copolyampholytes Produced from RAFT Polymerization of Protic Ionic Liquids

Celine CJ Fouillet, Tamar L Greaves, John F Quinn, Thomas P Davis, Jozef Adamcik, Marc-Antoine Sani, Frances Separovic, Calum J Drummond, Raffaele Mezzenga

Journal article  |  2017  |  Macromolecules

Implications of peptide assemblies in amyloid diseases

Pu Chun Ke, Marc-Antonie Sani, Feng Ding, Aleksandr Kakinen, Ibrahim Javed, Frances Separovic, Thomas P Davis, Raffaele Mezzenga

Journal article  |  2017  |  Chemical Society Reviews

Lipidic Cubic Phase-Induced Membrane Protein Crystallization: Interplay Between Lipid Molecular Structure, Mesophase Structure and Properties, and Crystallogenesis

Alexandru Zabara, Thomas G Meikle, Raphael Trenker, Shenggen Yao, Janet Newman, Thomas S Peat, Frances Separovic, Charlotte E Conn, Melissa J Call, Matthew E Call, Ehud M Landau, Calum J Drummond

Journal article  |  2017  |  Crystal Growth & Design

Amphiphilic lipopeptide significantly enhances uptake of charge-neutral splice switching morpholino oligonucleotide in spinal muscular atrophy patient-derived fibroblasts

Behnoosh Tajik-Ahmadabad, Anastasios Polyzos, Frances Separovic, Fazel Shabanpoor

Journal article  |  2017  |  International Journal of Pharmaceutics

One pathogen two stones: are Australian tree frog antimicrobial peptides synergistic against human pathogens?

Marc-Antoine Sani, Siobhan Carne, Sarah A Overall, Alexandre Poulhazan, Frances Separovic

Journal article  |  2017  |  European Biophysics Journal

Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation

Xinwei Ge, Aleksandr Kakinen, Esteban N Gurzov, Wen Yang, Lokman Pang, Emily H Pilkington, Praveen Govindan-Nedumpully, Pengyu Chen, Frances Separovic, Thomas P Davis, Pu Chun Ke, Feng Ding

Journal article  |  2017  |  Chem. Commun.

Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes

Mei-Ling Han, Hsin-Hui Shen, Karl A Hansford, Elena K Schneider, Sivashangarie Sivanesan, Kade D Roberts, Philip E Thompson, Anton P Le Brun, Yan Zhu, Marc-Antoine Sani, Frances Separovic, Mark AT Blaskovich, Mark A Baker, Samuel M Moskowitz, Matthew A Cooper, Jian Li, Tony Velkov

Journal article  |  2017  |  ACS Infectious Diseases

Phosphorylation of a full length amyloid-beta peptide modulates its amyloid aggregation, cell binding and neurotoxic properties

Elaheh Jamasbi, Frances Separovic, Mohammed Akhter Hossain, Giuseppe Donato Ciccotosto

Journal article  |  2017  |  Molecular BioSystems

Membrane-active peptides, IUPAB/EBSA symposium, Edinburgh

JM Sanderson, F Separovic

Journal article  |  2017  |  Biophysical Reviews

The efficient synthesis and purification of amyloid-beta(1-42) using an oligoethylene glycol-containing photocleavable lysine tag

John A Karas, Asif Noor, Christine Schieber, Timothy U Connell, Frances Separovic, Paul S Donnelly

Journal article  |  2017  |  Chemical Communications

A QCM-D and SAXS Study of the Interaction of Functionalised Lyotropic Liquid Crystalline Lipid Nanoparticles with siRNA

Behnoosh Tajik-Ahmadabad, Adam Mechler, Benjamin W Muir, Keith McLean, Tracey M Hinton, Frances Separovic, Anastasios Polyzos

Journal article  |  2017  |  ChemBioChem

Glycine Substitution Reduces Antimicrobial Activity and Helical Stretch of diPGLa-H in Lipid Micelles

M-A Sani, C Saenger, D Juretic, F Separovic

Journal article  |  2017  |  The Journal of Physical Chemistry B

A nanomechanical study of the effects of colistin on the Klebsiella pneumoniae AJ218 capsule

Anna Mularski, Jonathan Wilksch, Eric Hanssen, Jian Li, Takehiro Tomita, Sacha James Pidot, Tim Stinear, Frances Separovic, Dick Strugnell

Journal article  |  2017  |  European Biophysics Journal

Relaxin family peptides: structure-activity relationship studies

Nitin A Patil, K Johan Rosengren, Frances Separovic, John D Wade, Ross AD Bathgate, Mohammed Akhter Hossain

Journal article  |  2017  |  British Journal of Pharmacology

Incorporation of antimicrobial peptides in nanostructured lipid membrane mimetic bilayer cubosomes

Thomas G Meikle, Alexandru Zabara, Lynne J Waddington, Frances Separovic, Calum J Drummond, Charlotte E Conn

Journal article  |  2017  |  Colloids and Surfaces B: Biointerfaces

Chemical Synthesis and Characterization of an Equinatoxin II(1-85) Analogue

John A Karas, Marc-Antoine Sani, Frances Separovic

Journal article  |  2017  |  Molecules

Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR

Stephan L Grage, Marc-Antoine Sani, Olivier Cheneval, Sonia Troeira Henriques, Constantin Schalck, Ralf Heinzmann, Joshua S Mylne, Pavel K Mykhailiuk, Sergii Afonin, Igor V Komarov, Frances Separovic, David J Craik, Anne S Ulrich

Journal article  |  2017  |  Biophysical Journal

Predicting the release profile of small molecules from within the ordered nanostructured lipidic bicontinuous cubic phase using translational diffusion coefficients determined by PFG-NMR

Thomas G Meikle, Shenggen Yao, Alexandru Zabara, Charlotte E Conn, Calum J Drummond, Frances Separovic

Journal article  |  2017  |  Nanoscale

The Effect of Selective D- or N-alpha-Methyl Arginine Substitution on the Activity of the Proline-Rich Antimicrobial Peptide, Chex1-Arg20

Wenyi Li, Zhe Sun, Neil M O'Brien-Simpson, Laszlo Otvos, Eric C Reynolds, Mohammed A Hossain, Frances Separovic, John D Walde

Journal article  |  2017  |  Frontiers in Chemistry

C-Terminal Modification and Multimerization Increase the Efficacy of a Proline-Rich Antimicrobial Peptide

Wenyi Li, Neil M O'Brien-Simpson, Shenggen Yao, Julien Tailhades, Eric C Reynolds, Raymond M Dawson, Laszlo Otvos, Mohammed Akhter Hossain, Frances Separovic, John D Wade

Journal article  |  2017  |  Chemistry - A European Journal

Fluorescent Ion Efflux Screening Assay for Determining Membrane-Active Peptides

Neil M O'Brien-Simpson, Wenyi Li, Namfon Pantarat, Mohammed Akhter Hossain, Frances Separovic, John D Wade, Eric C Reynolds

Journal article  |  2017  |  Australian Journal of Chemistry

Atomic Force Microscopy Studies of the Interaction of Antimicrobial Peptides with Bacterial Cells

Anna Mularski, Frances Separovic

Journal article  |  2017  |  Australian Journal of Chemistry

Membrane-Mimetic Inverse Bicontinuous Cubic Phase Systems for Encapsulation of Peptides and Proteins

TG Meikle, CJ Drummond, F Separovic, CE Conn

Journal article  |  2017  |  Advances in Biomembranes and Lipid Self-Assembly

Interaction of the antimicrobial peptides caerin 1.1 and aurein 1.2 with intact bacteria by H-2 solid-state NMR

Marwa Laadhari, Alexandre A Arnold, Andree E Gravel, Frances Separovic, Isabelle Marcotte

Journal article  |  2016  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Membrane Insertion of a Dinuclear Polypyridylruthenium(II) Complex Revealed by Solid-State NMR and Molecular Dynamics Simulation: Implications for Selective Antibacterial Activity

Daniel K Weber, Marc-Antoine Sani, Matthew T Downton, Frances Separovic, F Richard Keene, J Grant Collins

Journal article  |  2016  |  Journal of the American Chemical Society

Antimicrobial Peptides Share a Common Interaction Driven by Membrane Line Tension Reduction

J Michael Henderson, Alan J Waring, Frances Separovic, Ka Yee C Lee

Journal article  |  2016  |  Biophysical Journal

A One-Pot Chemically Cleavable Bis-Linker Tether Strategy for the Synthesis of Heterodimeric Peptides

Nitin A Patil, Julien Tailhades, John A Karas, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Journal article  |  2016  |  Angewandte Chemie International Edition

A One-Pot Chemically Cleavable Bis-Linker Tether Strategy for the Synthesis of Heterodimeric Peptides

Nitin A Patil, Julien Tailhades, John A Karas, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Journal article  |  2016  |  Angewandte Chemie

Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability

John A Karas, Nitin A Patil, Julien Tailhades, Marc-Antoine Sani, Denis B Scanlon, Briony E Forbes, James Gardiner, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Journal article  |  2016  |  Angewandte Chemie

Despite recent advances in the treatment of diabetes mellitus, storage of insulin formulations at 4 °C is still necessary to minim..

Activity and conformation of lysozyme in molecular solvents, protic ionic liquids (PILs) and salt-water systems

Emmy C Wijaya, Frances Separovic, Calum J Drummond, Tamar L Greaves

Journal article  |  2016  |  Physical Chemistry Chemical Physics

Atomic force microscopy of bacteria reveals the mechanobiology of pore forming peptide action

Anna Mularski, Jonathan J Wilksch, Eric Hanssen, Richard A Strugnell, Frances Separovic

Journal article  |  2016  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

How Membrane-Active Peptides Get into Lipid Membranes

Marc-Antoine Sani, Frances Separovic

Journal article  |  2016  |  Accounts of Chemical Research

Membrane interactions of proline-rich antimicrobial peptide, Chex1-Arg20, multimers

Wenyi Li, Marc-Antoine Sani, Elaheh Jamasbi, Laszlo Otvos, Mohammed Akhter Hossain, John D Wade, Frances Separovic

Journal article  |  2016  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity

Nitin A Patil, Ross AD Bathgate, Martina Kocan, Sheng Yu Ang, Julien Tailhades, Frances Separovic, Roger Summers, Johannes Grosse, Richard A Hughes, John D Wade, Mohammed Akhter Hossain

Journal article  |  2016  |  Amino Acids

Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist

Nitin A Patil, Richard A Hughes, K Johan Rosengren, Martina Kocan, Sheng Yu Ang, Julien Tailhades, Frances Separovic, Roger J Summers, Johannes Grosse, John D Wade, Ross AD Bathgate, Mohammed Akhter Hossain

Journal article  |  2016  |  Journal of Medicinal Chemistry

Hypercrosslinked Additives for Ageless Gas-Separation Membranes

Cher Hon Lau, Xavier Mulet, Kristina Konstas, Cara M Doherty, Marc-Antoine Sani, Frances Separovic, Matthew R Hill, Colin D Wood

Journal article  |  2016  |  Angewandte Chemie International Edition

Amyloid Beta (A beta) Peptide and Factors that Play Important Roles in Alzheimer's Disease

Elaheh Jamasbi, John D Wade, Frances Separovic, Mohammed A Hossain

Journal article  |  2016  |  Current Medicinal Chemistry

Micelle formation of a non-ionic surfactant in non-aqueous molecular solvents and protic ionic liquids (PILs)

Emmy C Wijaya, Frances Separovic, Calum J Drummond, Tamar L Greaves

Journal article  |  2016  |  Physical Chemistry Chemical Physics

Exploring the structural relationship between encapsulated antimicrobial peptides and the bilayer membrane mimetic lipidic cubic phase: studies with gramicidin A '

Thomas G Meikle, Charlotte E Conn, Frances Separovic, Calum J Drummond

Journal article  |  2016  |  RSC Advances

Model Membrane and Cell Studies of Antimicrobial Activity of Melittin Analogues

Elaheh Jamasbi, Anna Mularski, Frances Separovic

Journal article  |  2016  |  Current Topics in Medicinal Chemistry

Proline-15 creates an amphipathic wedge in maculatin 1.1 peptides that drives lipid membrane disruption

Marc-Antoine Sani, Tzong-Hsien Lee, Marie-Isabel Aguilar, Frances Separovic

Journal article  |  2015  |  Biochimica et Biophysica Acta - Biomembranes

Site of fluorescent label modifies interaction of melittin with live cells and model membranes

Elaheh Jamasbi, Giuseppe D Ciccotosto, Julien Tailhades, Roy M Robins-Browne, Cathryn L Ugalde, Robyn A Sharples, Nitin Patil, John D Wade, Mohammed Akhter Hossain, Frances Separovic

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Membrane accessibility of glutathione

Alvaro Garcia, Nasma D Eljack, Marc-Antoine Sani, Frances Separovic, Helge H Rasmussen, Wojciech Kopec, Himanshu Khandelia, Flemming Cornelius, Ronald J Clarke

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

Multimerization of a Proline-Rich Antimicrobial Peptide, Chex-Arg20, Alters Its Mechanism of Interaction with the Escherichia coli Membrane

Wenyi Li, Neil M O'Brien-Simpson, Julien Tailhades, Namfon Pantarat, Raymond M Dawson, Laszlo Otvos, Eric C Reynolds, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Journal article  |  2015  |  Chemistry & Biology

The Prototypic Cyclotide Kalata B1 Has a Unique Mechanism of Entering Cells

Sonia Troeira Henriques, Yen-Hua Huang, Stephanie Chaousis, Marc-Antoine Sani, Aaron G Poth, Frances Separovic, David J Craik

Journal article  |  2015  |  Chemistry & Biology

Bacteria May Cope Differently from Similar Membrane Damage Caused by the Australian Tree Frog Antimicrobial Peptide Maculatin 1.1

Marc-Antoine Sani, Sonia Troeira Henriques, Daniel Weber, Frances Separovic

Journal article  |  2015  |  Journal of Biological Chemistry

Atomic Force Microscopy Reveals the Mechanobiology of Lytic Peptide Action on Bacteria

Anna Mularski, Jonathan J Wilksch, Huabin Wang, Mohammed Akhter Hossain, John D Wade, Frances Separovic, Richard A Strugnell, Michelle L Gee

Journal article  |  2015  |  Langmuir

Characterization of the Lipid-Binding Site of Equinatoxin II by NMR and Molecular Dynamics Simulation

Daniel K Weber, Shenggen Yao, Nejc Rojko, Gregor Anderluh, Terry P Lybrand, Matthew T Downton, John Wagner, Frances Separovic

Journal article  |  2015  |  Biophysical Journal

Progression of NMR studies of membrane-active peptides from lipid bilayers to live cells

M-A Sani, F Separovic

Journal article  |  2015  |  Journal of Magnetic Resonance

C-Terminal Modifications Broaden Activity of the Proline-Rich Antimicrobial Peptide, Chex1-Arg20

Wenyi Li, Julien Tailhades, M Akhter Hossain, Neil M O'Brien-Simpson, Eric C Reynolds, Laszlo Otvos, Frances Separovic, John D Wade

Journal article  |  2015  |  Australian Journal of Chemistry

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability

Vinojini B Nair, Ross AD Bathgate, Frances Separovic, Chrishan S Samuel, Mohammed Akhter Hossain, John D Wade

Journal article  |  2015  |  BioMed Research International

Cellular Disulfide Bond Formation in Bioactive Peptides and Proteins

Nitin A Patil, Julien Tailhades, Richard Anthony Hughes, Frances Separovic, John D Wade, Mohammed Akhter Hossain

Journal article  |  2015  |  International Journal of Molecular Sciences

Subtle Differences in Initial Membrane Interactions Underpin the Selectivity of Small Antimicrobial Peptides

Slavica Praporski, Adam Mechler, Frances Separovic, Lisandra L Martin

Journal article  |  2015  |  ChemPlusChem

Melittin peptides exhibit different activity on different cells and model membranes

Elaheh Jamasbi, Steven Batinovic, Robyn A Sharples, Marc-Antoine Sani, Roy Michael Robins-Browne, John D Wade, Frances Separovic, Mohammed Akhter Hossain

Journal article  |  2014  |  Amino Acids

Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria

Wenyi Li, Julien Tailhades, Neil M O'Brien-Simpson, Frances Separovic, Laszlo Otvos, M Akhter Hossain, John D Wade

Journal article  |  2014  |  Amino Acids

Comparison of reversible membrane destabilisation induced by antimicrobial peptides derived from Australian frogs

Tzong-Hsien Lee, Christine Heng, Frances Separovic, Marie-Isabel Aguilar

Journal article  |  2014  |  Biochimica et Biophysica Acta-Biomembranes

Membrane interactions and biological activity of antimicrobial peptides from Australian scorpion

Karen Luna-Ramirez, Marc-Antoine Sani, Jesus Silva-Sanchez, Juana Maria Jimenez-Vargas, Fernando Reyna-Flores, Kenneth D Winkel, Christine E Wright, Lourival D Possani, Frances Separovic

Journal article  |  2014  |  Biochimica et Biophysica Acta-Biomembranes

Dye-release assay for investigation of antimicrobial peptide activity in a competitive lipid environment

Marc-Antoine Sani, Eve Gagne, John D Gehman, Thomas C Whitwell, Frances Separovic

Journal article  |  2014  |  European Biophysics Journal with Biophysics Letters

2-Nitroveratryl as a Photocleavable Thiol-Protecting Group for Directed Disulfide Bond Formation in the Chemical Synthesis of Insulin

John A Karas, Denis B Scanlon, Briony E Forbes, Irina Vetter, Richard J Lewis, James Gardiner, Frances Separovic, John D Wade, Mohammed A Hossain

Journal article  |  2014  |  Chemistry - A European Journal

Measuring translational diffusion coefficients of peptides and proteins by PFG-NMR using band-selective RF pulses

Shenggen Yao, Daniel K Weber, Frances Separovic, David W Keizer

Journal article  |  2014  |  European Biophysics Journal with Biophysics Letters

The investigation of membrane binding by amphibian peptide agonists of CCK2R using P-31 and H-2 solid-state NMR

Patrick J Sherman, Frances Separovic, John H Bowie

Journal article  |  2014  |  Peptides

Dye release experiments with dextran loaded vesicles

M Sani, NM O'Brien-Simpson, F Separovic

Journal article  |  2014  |  Bio-protocol

Relaxin and its role in fibrotic diseases

Linda Jiaying Chan, Chrishan S Samuel, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Book Chapter  |  2014  |  Amino Acids, Peptides and Proteins

Cyclization enhances function of linear anti-arthritic peptides

Marina Ali, Michael Amon, Vera Bender, Andrea Bolte, Frances Separovic, Heather Benson, Nicholas Manolios

Journal article  |  2014  |  Clinical Immunology

Solid-State NMR Studies of Antimicrobial Peptide Interactions with Specific Lipid Environments

Marc-Antoine Sani, Frances Separovic

Book Chapter  |  2014  |  New Developments in NMR

Bacterial fluorescent-dextran diffusion assay

NM O'Brien-Simpson, N Pantarat, KA Walsh, EC Reynolds, M Sani, F Separovic

Journal article  |  2014  |  Bio-protocol

Controlling nanostructure and lattice parameter of the inverse bicontinuous cubic phases in functionalised phytantriol dispersions

Scott J Fraser, Xavier Mulet, Adrian Hawley, Frances Separovic, Anastasios Polyzos

Journal article  |  2013  |  Journal of Colloid and Interface Science

Membrane defects enhance the interaction of antimicrobial peptides, aurein 1.2 versus caerin 1.1

David I Fernandez, Marc-Antoine Sani, Andrew J Miles, BA Wallace, Frances Separovic

Journal article  |  2013  |  Biochimica et Biophysica Acta-Biomembranes

Maculatin 1.1 Disrupts Staphylococcus aureus Lipid Membranes via a Pore Mechanism

M-A Sani, TC Whitwell, JD Gehman, RM Robins-Browne, N Pantarat, TJ Attard, EC Reynolds, NM O'Brien-Simpson, F Separovic

Journal article  |  2013  |  Antimicrobial Agents and Chemotherapy

Proline Facilitates Membrane Insertion of the Antimicrobial Peptide Maculatin 1.1 via Surface Indentation and Subsequent Lipid Disordering

David I Fernandez, Tzong-Hsien Lee, Marc-Antoine Sani, Marie-Isabel Aguilar, Frances Separovic

Journal article  |  2013  |  Biophysical Journal

The Importance of Tryptophan B28 in H2 Relaxin for RXFP2 Binding and Activation

Linda J Chan, John D Wade, Frances Separovic, Ross AD Bathgate, Mohammed Akhter Hossain

Journal article  |  2013  |  International Journal of Peptide Research and Therapeutics

A practical implementation of de-Pake-ing via weighted Fourier transformation

Marc-Antoine Sani, Daniel K Weber, Frank Delaglio, Frances Separovic, John D Gehman

Journal article  |  2013  |  PeerJ

Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization

Linda J Chan, Craig M Smith, Berenice E Chua, Feng Lin, Ross AD Bathgate, Frances Separovic, Andrew L Gundlach, Mohammed Akhter Hossain, John D Wade

Journal article  |  2013  |  Frontiers in Chemistry

Structural effects of the antimicrobial peptide maculatin 1.1 on supported lipid bilayers

David I Fernandez, Anton P Le Brun, Tzong-Hsien Lee, Paramjit Bansal, Marie-Isabel Aguilar, Michael James, Frances Separovic

Journal article  |  2013  |  European Biophysics Journal with Biophysics Letters

Total chemical synthesis of a heterodimeric interchain bis-lactam-linked Peptide: application to an analogue of human insulin-like Peptide 3.

John Karas, Fazel Shabanpoor, Mohammed Akhter Hossain, James Gardiner, Frances Separovic, John D Wade, Denis B Scanlon

Journal article  |  2013  |  International Journal of Peptides

Nonreducible cystine isosteres represent important peptide design elements in that they can maintain a near-native tertiary confor..

Amino Acids, Peptides and Proteins

Book Chapter  |  2013

The lipid network.

Marc-Antoine Sani, Frances Separovic, John D Gehman

Journal article  |  2012  |  Biophysical Reviews

Natural cell membranes are composed of a remarkable variety of lipids, which provide specific biophysical properties to support me..

Identification of Key Residues Essential for the Structural Fold and Receptor Selectivity within the A-chain of Human Gene-2 (H2) Relaxin

Linda J Chan, K Johan Rosengren, Sharon L Layfield, Ross AD Bathgate, Frances Separovic, Chrishan S Samuel, Mohammed A Hossain, John D Wade

Journal article  |  2012  |  Journal of Biological Chemistry

Host-defense peptides of Australian anurans. Part 2. Structure, activity, mechanism of action, and evolutionary significance

John H Bowie, Frances Separovic, Michael J Tyler

Journal article  |  2012  |  Peptides

Human relaxin-2: historical perspectives and role in cancer biology

Vinojini B Nair, Chrishan S Samuel, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Journal article  |  2012  |  Amino Acids

Electrochemistry of Room Temperature Protic Ionic Liquids: A Critical Assessment for Use as Electrolytes in Electrochemical Applications

Xunyu Lu, Geoff Burrell, Frances Separovic, Chuan Zhao

Journal article  |  2012  |  Journal of Physical Chemistry B

Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1

Fazel Shabanpoor, Mohammad Alchter Hossain, Philip J Ryan, Alessia Belgi, Sharon Layfield, Martina Kocan, Suode Zhang, Chrishan S Samuel, Andrew L Gundlach, Ross AD Bathgate, Frances Separovic, John D Wade

Journal article  |  2012  |  Journal of Medicinal Chemistry

Lipid composition regulates the conformation and insertion of the antimicrobial peptide maculatin 1.1

Marc-Antoine Sani, Thomas C Whitwell, Frances Separovic

Journal article  |  2012  |  Biochimica et Biophysica Acta-Biomembranes

Membrane protein structure and function Preface

Toby W Allen, Frances Separovic

Journal article  |  2012  |  Biochimica et Biophysica Acta-Biomembranes

Surface Immobilization of Bio-Functionalized Cubosomes: Sensing of Proteins by Quartz Crystal Microbalance

Scott J Fraser, Xavier Mulet, Lisandra Martin, Slavica Praporski, Adam Mechler, Patrick G Hartley, Anastasios Polyzos, Frances Separovic

Journal article  |  2012  |  Langmuir

The antimicrobial peptide aurein 1.2 disrupts model membranes via the carpet mechanism

David I Fernandez, Anton P Le Brun, Thomas C Whitwell, Marc-Antoine Sani, Michael James, Frances Separovic

Journal article  |  2012  |  Physical Chemistry Chemical Physics

Copper Modulation of Amyloid Beta 42 Interactions with Model Membranes

Daniel K Weber, John D Gehman, Frances Separovic, Marc-Antoine Sani

Journal article  |  2012  |  Australian Journal of Chemistry

Disentanglement of Heterogeneous Dynamics in Mixed Lipid Systems

Marc-Antoine Sani, Frances Separovic, John D Gehman

Journal article  |  2011  |  Biophysical Journal

Modeling the Membrane Environment for Membrane Proteins

Frances Separovic, J Antoinette Killian, Myriam Cotten, David D Busath, Timothy A Cross

Journal article  |  2011  |  Biophysical Journal

Interactions of a synthetic Leu-Lys-rich antimicrobial peptide with phospholipid bilayers

David I Fernandez, Marc-Antoine Sani, John D Gehman, Kyung-Soo Hahm, Frances Separovic

Journal article  |  2011  |  European Biophysics Journal with Biophysics Letters

Special issue on membrane-active peptides

Sergiy Afonin, Davor Juretic, Frances Separovic, Anne S Ulrich

Journal article  |  2011  |  European Biophysics Journal with Biophysics Letters

QCM-D fingerprinting of membrane-active peptides

George A McCubbin, Slavica Praporski, Stefania Piantavigna, Daniel Knappe, Ralf Hoffmann, John H Bowie, Frances Separovic, Lisandra L Martin

Journal article  |  2011  |  European Biophysics Journal with Biophysics Letters

Lipid matrix plays a role in Abeta fibril kinetics and morphology

Marc-Antoine Sani, John D Gehman, Frances Separovic

Journal article  |  2011  |  FEBS Letters

General method for selective labelling of double-chain cysteine-rich peptides with a lanthanide chelate via solid-phase synthesis

Fazel Shabanpoor, Frances Separovic, John D Wade

Journal article  |  2011  |  Journal of Peptide Science

Stereospecific interactions are necessary for Alzheimer disease amyloid-beta toxicity

Giuseppe D Ciccotosto, Deborah J Tew, Simon C Drew, Danielle G Smith, Timothy Johanssen, Varsha Lal, Tong-Lay Lau, Keyla Perez, Cyril C Curtain, John D Wade, Frances Separovic, Colin L Masters, Jeffrey P Smith, Kevin J Barnham, Roberto Cappai

Journal article  |  2011  |  Neurobiology of Aging

Development of Cubosomes as a Cell-Free Biosensing Platform

Scott J Fraser, Raymond M Dawson, Lynne J Waddington, Ben W Muir, Xavier Mulet, Patrick G Hartley, Frances Separovic, Anastasios Polyzos

Journal article  |  2011  |  Australian Journal of Chemistry

Solid-State NMR of Membrane-Acting Antimicrobial Peptides

John D Gehman, Marc-Antoine Sani, Frances Separovic

Book Chapter  |  2011  |  Advances in Biomedical Spectroscopy

Interactions of the Antimicrobial Peptide Maculatin 1.1 and Analogues with Phospholipid Bilayers

David I Fernandez, Marc-Antoine Sani, Frances Separovic

Journal article  |  2011  |  Australian Journal of Chemistry

Design and Development of Analogues of Dimers of Insulin-like Peptide 3 B-Chain as High-Affinity Antagonists of the RXFP2 Receptor

Fazel Shabanpoor, Suode Zhang, Richard A Hughes, Mohammed Akhter Hossain, Sharon Layfield, Tania Ferraro, Ross AD Bathgate, Frances Separovic, John D Wade

Journal article  |  2011  |  Biopolymers

Solid-State NMR of Amyloid Membrane Interactions

John D Gehman, Frances Separovic

Book Chapter  |  2011  |  Methods in Molecular Biology

The Relaxin Peptide Family-Structure, Function and Clinical Applications

Linda Jiaying Chan, Mohammed Akhter Hossain, Chrishan S Samuel, Frances Separovic, John D Wade

Journal article  |  2011  |  Protein and Peptide Letters

Preparation and biological evaluation of self-assembled cubic phases for the polyvalent inhibition of cholera toxin

Scott J Fraser, Rachel Rose, Meghan K Hattarki, Patrick G Hartley, Olan Dolezal, Raymond M Dawson, Frances Separovic, Anastasios Polyzos

Journal article  |  2011  |  Soft Matter

Anionic Phospholipid Interactions of the Prion Protein N Terminus Are Minimally Perturbing and Not Driven Solely by the Octapeptide Repeat Domain

Martin P Boland, Claire R Hatty, Frances Separovic, Andrew F Hill, Deborah J Tew, Kevin J Barnham, Cathryn L Haigh, Michael James, Colin L Masters, Steven J Collins

Journal article  |  2010  |  Journal of Biological Chemistry

Real-time quantitative analysis of lipid disordering by aurein 1.2 during membrane adsorption, destabilisation and lysis

Tzong-Hsien Lee, Christine Heng, Marcus J Swann, John D Gehman, Frances Separovic, Marie-Isabel Aguilar

Journal article  |  2010  |  Biochimica et Biophysica Acta-Biomembranes

NMR Relaxation and Self-Diffusion Study at High and Low Magnetic Fields of Ionic Association in Protic Ionic Liquids

Geoffrey L Burrell, Iko M Burgar, Qingxia Gong, Noel F Dunlop, Frances Separovic

Journal article  |  2010  |  Journal of Physical Chemistry B

Self-Assembly of Peptides into Spherical Nanoparticles for Delivery of Hydrophilic Moieties to the Cytosol

Louise Collins, Alan L Parker, John D Gehman, Lorna Eckley, Matthew A Perugini, Frances Separovic, John W Fabre

Journal article  |  2010  |  ACS Nano

Solid-state NMR and simulation studies of equinatoxin II N-terminus interaction with lipid bilayers

Yuen Han Lam, Andrew Hung, Raymond S Norton, Frances Separovic, Anthony Watts

Journal article  |  2010  |  Proteins - Structure, Function, and Bioinformatics

Solid-state NMR study of membrane interactions of the pore-forming cytolysin, equinatoxin II

Alison Drechsler, Gregor Anderluh, Raymond S Norton, Frances Separovic

Journal article  |  2010  |  Biochimica et Biophysica Acta-Biomembranes

Preparation of protic ionic liquids with minimal water content and N-15 NMR study of proton transfer

Geoffrey L Burrell, Iko M Burgar, Frances Separovic, Noel F Dunlop

Journal article  |  2010  |  Physical Chemistry Chemical Physics

Non-Newtonian viscous shear thinning in ionic liquids

Geoffrey L Burrell, Noel F Dunlop, Frances Separovic

Journal article  |  2010  |  Soft Matter

Effect of helix-promoting strategies on the biological activity of novel analogues of the B-chain of INSL3

Fazel Shabanpoor, Richard A Hughes, Suode Zhang, Ross AD Bathgate, Sharon Layfield, Mohammed Akhter Hossain, Geoffrey W Tregear, Frances Separovic, John D Wade

Journal article  |  2010  |  Amino Acids

Solution Structure and Membrane Interactions of the Antimicrobial Peptide Fallaxidin 4.1a: An NMR and QCM Study

Patrick J Sherman, Rebecca J Jackway, John D Gehman, Slavica Praporski, George A McCubbin, Adam Mechler, Lisandra L Martin, Frances Separovic, John H Bowie

Journal article  |  2009  |  Biochemistry

Effect of lipid on the conformation of the N-terminal region of equinatoxin II: a synchrotron radiation circular dichroism spectroscopic study

Alison Drechsler, Andrew J Miles, Raymond S Norton, BA Wallace, Frances Separovic

Journal article  |  2009  |  European Biophysics Journal with Biophysics Letters

Cubic phases of ternary amphiphile-water systems

Scott Fraser, Frances Separovic, Anastasios Polyzos

Journal article  |  2009  |  European Biophysics Journal with Biophysics Letters

Membrane interactions of antimicrobial peptides from Australian frogs

David I Fernandez, John D Gehman, Frances Separovic

Journal article  |  2009  |  Biochimica et Biophysica Acta-Biomembranes

Physicochemical Characterization and Stability of Rifampicin Liposome Dry Powder Formulations for Inhalation

Narumon Changsan, Hak-Kim Chan, Frances Separovic, Teerapol Srichana

Journal article  |  2009  |  Journal of Pharmaceutical Sciences

THE HUMAN INSULIN SUPERFAMILY OF POLYPEPTIDE HORMONES

Fazel Shabanpoor, Frances Separovic, John D Wade

Book Chapter  |  2009  |  Vitamins and Hormones: Advances in Research and Applications

Host-Defense Peptides from the Secretion of the Skin Glands of Frogs and Toads: Membrane-Active Peptides from the Genera Litoria, Uperoleia, and Crinia

H Bowie, J Jackway, F SEPAROVIC, A Carver, J Tyler

Book Chapter  |  2009

The chemistry and biology of insulin-like peptide 3, a novel member of the insulin superfamily.

F SHABANPOOR, R HUGHES, F SEPAROVIC, J WADE

Book Chapter  |  2009

Development of Lanthanide-Labeled Human INSL3 as an Alternative Probe to Radioactively Labeled INSL3 for Use in Bioassays

Fazel Shabanpoor, Richard A Hughes, Ross AD Bathgate, Frances Separovic, John D Wade

Book Chapter  |  2009  |  Annals of the New York Academy of Sciences

The effects of lipids on the structure of the eukaryotic cytolysin equinatoxin II: A synchrotron radiation circular dichroism spectroscopic study

Andrew J Miles, Alison Drechsler, Katarina Kristan, Gregor Anderluh, Raymond S Norton, BA Wallace, Frances Separovic

Journal article  |  2008  |  Biochimica et Biophysica Acta-Biomembranes

Effect of antimicrobial peptides from Australian tree frogs on anionic phospholipid membranes

John D Gehman, Fiona Luc, Kristopher Hall, Tzong-Hsien Lee, Martin P Boland, Tara L Pukala, John H Bowie, Marie-Isabel Aguilar, Frances Separovic

Journal article  |  2008  |  Biochemistry

Solid-phase synthesis of europium-labeled human INSL3 as a novel probe for the study of ligand-receptor interactions

Fazel Shabanpoor, Richard A Hughes, Ross AD Bathgate, Suode Zhang, Denis B Scanlon, Feng Lin, Mohammed Akhter Hossain, Frances Separovic, John D Wade

Journal article  |  2008  |  Bioconjugate Chemistry

A solid-state NMR study of the interaction of fish antifreeze proteins with phospholipid membranes

James Garner, Steven R Inglis, James Hook, Frances Separovic, Margaret M Harding

Journal article  |  2008  |  European Biophysics Journal with Biophysics Letters

Liposomal phospholipid preparations of chloramphenicol for ophthalmic applications

Sherif S Mahmoud, John D Gehman, Kristy Azzopardi, Roy M Robins-Browne, Frances Separovic

Journal article  |  2008  |  Journal of Pharmaceutical Sciences

Electrochemistry of room temperature protic ionic liquids

Chuan Zhao, Geoff Burrell, Angel AJ Torriero, Frances Separovic, Noel F Dunlop, Douglas R MacFarlane, Alan M Bond

Journal article  |  2008  |  Journal of Physical Chemistry B

Metal effects on the membrane interactions of amyloid-beta peptides

John D Gehman, Caitlin C O'Brien, Fazel Shabanpoor, John D Wade, Frances Separovic

Journal article  |  2008  |  European Biophysics Journal with Biophysics Letters

Metals and membranes in neuroscience - Preface

Cyril Curtain, Frances Separovic

Journal article  |  2008  |  European Biophysics Journal with Biophysics Letters

Determination of Rifampicin Location in Cholesterol-Lipid Liposomes by H-2 and P-31 Solid-State NMR

N Changsan, F Separovic, T Srichana

Journal article  |  2008  |  2008 2nd IEEE International Nanoelectronics Conference

Solid-State NMR of Membrane-Active Proteins and Peptides

John D Gehman, Frances Separovic

Book Chapter  |  2007  |  ChemInform

Cholesterol and Clioquinol modulation of A beta(1-42) interaction with phospholipid bilayers and metals

Tong-Lay Lau, John D Gehman, John D Wade, Colin L Masters, Kevin J Barnham, Frances Separovic

Journal article  |  2007  |  Biochimica et Biophysica Acta-Biomembranes

Specific and selective peptide-membrane interactions revealed using quartz crystal microbalance

Adam Mechler, Slavica Praporski, Kiran Atmuri, Martin Boland, Frances Separovic, Lisandra L Martin

Journal article  |  2007  |  Biophysical Journal

Characterisation of the extracellular polysaccharides produced by isolates of the fungus Acremonium

Frank Schmid, Frances Separovic, Barbara A McDougall, Bruce A Stone, Robert TC Brownlee, Robert J Seviour

Journal article  |  2007  |  Carbohydrate Research

Interactions of the Australian tree frog antimicrobial peptides aurein 1.2, citropin 1.1 and maculatin 1.1 with lipid model membranes: Differential scanning calorimetric and Fourier transform infrared spectroscopic studies

Gordon WJ Seto, Seema Marwaha, Daniel M Kobewka, Ruthven NAH Lewis, Frances Separovic, Ronald N McElhaney

Journal article  |  2007  |  Biochimica et Biophysica Acta-Biomembranes

Membrane interactions and the effect of metal ions of the amyloidogenic fragment A beta(25-35) in comparison to A beta(1-42)

Tong-Lay Lau, John D Gehman, John D Wade, Keyla Perez, Colin L Masters, Kevin J Barnham, Frances Separovic

Journal article  |  2007  |  Biochimica et Biophysica Acta-Biomembranes

Boltzmann statistics rotational-echo double-resonance analysis

John D Gehman, Frances Separovic, Kun Lu, Anil K Mehta

Journal article  |  2007  |  Journal of Physical Chemistry B

beta-sheet structured beta-amyloid(1-40) perturbs phosphatidylcholine model membranes

Maurits RR de Planque, Vincent Raussens, Sonia Antoranz Contera, Dirk TS Rijkers, Rob MJ Liskamp, Jean-Marie Ruysschaert, John F Ryan, Frances Separovic, Anthony Watts

Journal article  |  2007  |  Journal of Molecular Biology

The conformation of acetylated virginiamycin M-1 and virginiamycin M-1 in explicit solvents

Chai Ann Ng, Wen Zhao, Jason Dang, Mikael Bergdahl, Frances Separovic, Robert TC Brownlee, Robert P Metzger

Journal article  |  2007  |  Biochimica et Biophysica Acta-Biomembranes

Selective permeabilization of the host cell membrane of Plasmodium falciparum-infected red blood cells with streptolysin O and equinatoxin II

Katherine E Jackson, Tobias Spielmann, Eric Hanssen, Akinola Adisa, Frances Separovic, Matthew WA Dixon, Katharine R Trenholme, Paula L Hawthorne, Don L Gardiner, Tim Gilberger, Leann Tilley

Journal article  |  2007  |  Biochemical Journal

Cupiennin 1a, an antimicrobial peptide from the venom of the neotropical wandering spider Cupiennius salei, also inhibits the formation of nitric oxide by neuronal nitric oxide synthase

Tara L Pukala, Jason R Doyle, Lyndon E Llewellyn, Lucia Kuhn-Nentwig, Margit A Apponyi, Frances Separovic, John H Bowie

Journal article  |  2007  |  FEBS Journal

Solution structure and interaction of cupiennin 1a, a spider venom peptide, with phospholipid bilayers

Tara L Pukala, Martin P Boland, John D Gehman, Lucia Kuhn-Nentwig, Frances Separovic, John H Bowie

Journal article  |  2007  |  Biochemistry

Gated ion channel based biosensor device

F SEPAROVIC, A Cornell

Book Chapter  |  2007

170 MQMAS NMR characterisation of geopolymers

P DUXSON, J GEHMAN, CE WHITE, J PROVIS, F SEPAROVIC, undefined Gan, J VAN DEVENTER

Conference Proceedings  |  2007  |  Proceedings of the 35th Australasian Chemical Engineering Conference Proceedings

From physics to biology (book review)

J GEHMAN, F SEPAROVIC

Journal article  |  2007  |  Australian Physics

International trend in biophysics - The Australian Society for Biophysics: a brief history.

undefined Norton, F SEPAROVIC

Journal article  |  2007  |  Seibutsu Butsuri

K-39 NMR of free potassium in geopolymers

P Duxson, JL Provis, GC Lukey, JSJ van Deventer, F Separovic, ZH Gan

Journal article  |  2006  |  Industrial & Engineering Chemistry Research

Effect of linker length on avidin binding to biotinylated gramicidin A

Aphrodite Anastasiadis, Craig J Morton, Gert H Talbo, Roger E Koeppe, Frances Separovic

Journal article  |  2006  |  International Journal of Peptide Research and Therapeutics

Membrane interactions of antimicrobial peptides from Australian tree frogs

Martin P Boland, Frances Separovic

Journal article  |  2006  |  Biochimica et Biophysica Acta-Biomembranes

Orientational order of Australian spider silks as determined by solid-state NMR

B Bonev, S Grieve, ME Herberstein, AI Kishore, A Watts, F Separovic

Journal article  |  2006  |  Biopolymers

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge

David P Smith, Danielle G Smith, Cyril C Curtain, John F Boas, John R Pilbrow, Giuseppe D Ciccotosto, Tong-Lay Lau, Deborah J Tew, Keyla Perez, John D Wade, Ashley I Bush, Simon C Drew, Frances Separovic, Colin L Masters, Roberto Cappai, Kevin J Barnham

Journal article  |  2006  |  Journal of Biological Chemistry

Copper and zinc mediated oligomerisation of A beta peptides

Feda E Ali, Frances Separovic, Colin J Barrow, Shenggen Yao, Kevin J Barnham

Journal article  |  2006  |  International Journal of Peptide Research and Therapeutics

Interfacial properties of the M1 segment of the nicotinic acetylcholine receptor

Ernesto E Ambroggio, Marcos A Villarreal, Guillermo G Montich, Dirk TS Rijkers, Maurits RR De Planque, Frances Separovic, Gerardo D Fidelio

Journal article  |  2006  |  Biophysical Chemistry

Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions

TL Lau, EE Ambroggio, DJ Tew, R Cappai, CL Masters, GD Fidelio, KJ Barnham, F Separovic

Journal article  |  2006  |  Journal of Molecular Biology

Structure and activity of the N-terminal region of the eukaryotic cytolysin equinatoxin II

A Drechsler, C Potrich, JK Sabo, M Frisanco, G Guella, M Dalla Serra, G Anderluh, F Separovic, RS Norton

Journal article  |  2006  |  Biochemistry

Dimerisation of N-acetyl-L-tyrosine ethyl ester and A beta peptides via formation of dityrosine

FE Ali, A Leung, RA Cherny, C Mavros, KJ Barnham, F Separovic, CJ Barrow

Journal article  |  2006  |  Free Radical Research

Amino functionalisation of microemulsion templated mesoporous silica foams

S Boskovic, F Separovic, TW Turney, GW Stevens, ML Gee, AJ O'Connor

Journal article  |  2006  |  Studies in Surface Science and Catalysis

Amino functionalisation of microemulsion templated mesoporous silica foams.

S BOSKOVIC, F SEPAROVIC, W Turney, G STEVENS, M GEE, A O'CONNOR

Book Chapter  |  2006

Modeling speciation in highly concentrated alkaline silicate solutions

JL Provis, P Duxson, GC Lukey, F Separovic, WM Kriven, JSJ van Deventer

Journal article  |  2005  |  Industrial & Engineering Chemistry Research

Direct visualization of membrane leakage induced by the antibiotic peptides: Maculatin, citropin, and aurein

EE Ambroggio, F Separovic, JH Bowie, GD Fidelio, LA Bagatolli

Journal article  |  2005  |  Biophysical Journal

Postsynthesis vapor-phase functionalization of MCM-48 with hexamethyldisilazane and 3-aminopropyldimethylethoxylsilane for bioseparation applications

A Daehler, S Boskovic, ML Gee, F Separovic, GW Stevens, AJ O'Connor

Journal article  |  2005  |  Journal of Physical Chemistry B

The role of A beta peptides in Alzheimer's disease

AK Tickler, JD Wade, F Separovic

Journal article  |  2005  |  Protein and Peptide Letters

The conformational flexibility of the antibiotic virginiamycin M-1

J Dang, RP Metzger, RTC Brownlee, CA Ng, M Bergdahl, F Separovic

Journal article  |  2005  |  European Biophysics Journal with Biophysics Letters

Methionine regulates copper/hydrogen peroxide oxidation products of A beta

FE Ali, F Separovic, CJ Barrow, RA Cherny, F Fraser, AI Bush, CL Masters, KJ Barnham

Journal article  |  2005  |  Journal of Peptide Science

Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: A membrane-disrupting peptide

EE Ambroggio, DH Kim, F Separovic, CJ Barrow, CJ Barrow, KJ Barnham, LA Bagatolli, GD Fidelio

Journal article  |  2005  |  Biophysical Journal

Si-29 NMR study of structural ordering in aluminosilicate geopolymer gels

P Duxson, JL Provis, GC Lukey, F Separovic, JSJ van Deventer

Journal article  |  2005  |  Langmuir

Interaction of the eukaryotic pore-forming cytolysin equinatoxin II with model membranes: F-19 NMR studies

G Anderluh, A Razpotnik, Z Podlesek, P Macek, F Separovic, RS Norton

Journal article  |  2005  |  Journal of Molecular Biology

Matrix method for analysis of selective NMR pulses

YA Tesiram, F Separovic

Journal article  |  2005  |  Concepts in Magnetic Resonance - Part A

Effect of alkali cations on aluminum incorporation in geopolymeric gels

P Duxson, GC Lukey, F Separovic, JSJ van Deventer

Journal article  |  2005  |  Industrial & Engineering Chemistry Research

Developments in Hyphenated Spectroscopic Methods in Natural Product Profiling

Sylvia Urban, Frances Separovic

Book Chapter  |  2005  |  Frontiers in Medicinal Chemistry

The alpha-M1 segment of the nicotinic acetylcholine receptor exhibits conformational flexibility in a membrane environment

MRR de Planque, DTS Rijkers, JI Fletcher, RMJ Liskamp, F Separovic

Journal article  |  2004  |  Biochimica et Biophysica Acta-Biomembranes

Surface behaviour and peptide-lipid interactions of the antibiotic peptides, Maculatin and Citropin

EE Ambroggio, F Separovic, J Bowie, GD Fidelio

Journal article  |  2004  |  Biochimica et Biophysica Acta-Biomembranes

Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance

MA Apponyi, TL Pukala, CS Brinkworth, VM Maselli, JH Bowie, MJ Tyler, GW Booker, JC Wallace, JA Carver, F Separovic, J Doyle, LE Llewellyn

Journal article  |  2004  |  Peptides

Solid-state NMR study of antimicrobial peptides from Australian frogs in phospholipid membranes

MS Balla, JH Bowie, F Separovic

Journal article  |  2004  |  European Biophysics Journal with Biophysics Letters

NMR structural elucidation of amino resins

AS Angelatos, MI Burgar, N Dunlop, F Separovic

Journal article  |  2004  |  Journal of Applied Polymer Science

A multidimensional H-1 NMR investigation of the conformation of methionine-enkephalin in fast-tumbling bicelles

I Marcotte, F Separovic, M Auger, SM Gagne

Journal article  |  2004  |  Biophysical Journal

The alpha M1 transmembrane segment of the nicotinic acetylcholine receptor interacts strongly with model membranes

MRR de Planque, DTS Rijkers, RMJ Liskamp, F Separovic

Journal article  |  2004  |  Magnetic Resonance in Chemistry

Metal catalyzed oxidation of tyrosine residues by different oxidation systems of copper/hydrogen peroxide

FE Ali, KJ Barnham, CJ Barrow, F Separovic

Journal article  |  2004  |  Journal of Inorganic Biochemistry

Difference in conformation of virginiamycin M-1 in chloroform and bound form in the 50S ribosome or streptogramin acetyltransferase

J Dang, BM Bergdahl, F Separovic, RTC Brownlee, RP Metzger

Journal article  |  2004  |  Australian Journal of Chemistry

An introduction to biological solid state NMR

A Dodd, F Separovic

Book Chapter  |  2004

Solvent affects the conformation of virginiamycin M-1 (pristinamycin IIA, streptogramin A)

J Dang, M Bergdahl, F Separovic, RTC Brownlee, RP Metzger

Journal article  |  2004  |  Organic & Biomolecular Chemistry

Magnetic moments: membrane protein structures by NMR

F SEPAROVIC, AP DRECHSLER, TL LAU

Journal article  |  2004  |  Chemistry in Australia

Metal-catalyzed oxidative damage and oligomerization of the amyloid-peptide of Alzheimer's disease

FEA Ali, KJ Barnham, CJ Barrow, F Separovic

Journal article  |  2004  |  Australian Journal of Chemistry

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

KJ Barnham, GD Ciccotosto, AK Tickler, FE Ali, DG Smith, NA Williamson, YH Lam, D Carrington, D Tew, G Kocak, I Volitakis, F Separovic, CJ Barrow, JD Wade, CL Masters, RA Cherny, CC Curtain, AI Bush, R Cappai

Journal article  |  2003  |  Journal of Biological Chemistry

Solid-state NMR structure determination

A Drechsler, F Separovic

Journal article  |  2003  |  IUBMB Life

Interfacial anchor properties of tryptophan residues in transmembrane peptides can dominate over hydrophobic matching effects in peptide-lipid interactions

MRR de Planque, BB Bonev, JAA Demmers, DV Greathouse, RE Koeppe, F Separovic, A Watts, JA Killian

Journal article  |  2003  |  Biochemistry

Effects of the eukaryotic pore-forming cytolysin equinatoxin II on lipid membranes and the role of sphingomyelin

BB Bonev, YH Lam, G Anderluh, A Watts, RS Norton, F Separovic

Journal article  |  2003  |  Biophysical Journal

Interaction of antimicrobial peptides from Australian amphibians with lipid membranes

I Marcotte, KL Wegener, YH Lam, BCS Chia, MRR de Planque, JH Bowie, M Auger, F Separovic

Journal article  |  2003  |  Chemistry and Physics of Lipids

Magnetic resonance studies of beta-amyloid peptides

TL Lau, KJ Barnham, CC Curtain, CL Masters, F Separovic

Journal article  |  2003  |  Australian Journal of Chemistry

Solid-state NMR structural determination of components in an ion channel switch biosensor

A Anastasiadis, F Separovic

Journal article  |  2003  |  Australian Journal of Chemistry

Surface coating of MCM-48 via a gas phase reaction with hexamethyldisilazane (HMDS)

A Daehler, ML Gee, F Separovic, GW Stevens, AJ O'Connor

Conference Proceedings  |  2003  |  Studies in surface science and catalysis 146 - Nanotechnology in mesostructured materials

The aromaticity of ferrocene and some derivatives, ruthenocene and dibenzenechromium as determined via ring current assessment and C-13 anisotropic contributions to the H-1 NMR shielding

L Phillips, F Separovic, MJ Aroney

Journal article  |  2003  |  New Journal of Chemistry

Copper catalysed oxidation of amino acids and Alzheimer's disease

FE Ali, KJ Barnham, CJ Barrow, F Separovic

Journal article  |  2003  |  Letters in Peptide Science

Solid-state NMR conformational studies of a melittin-inhibitor complex

YH Lam, CJ Morton, F Separovic

Journal article  |  2002  |  European Biophysics Journal with Biophysics Letters

A solid-state NMR study of protein mobility in lyophilized protein-sugar powders

YH Lam, R Bustami, T Phan, HK Chan, F Separovic

Journal article  |  2002  |  Journal of Pharmaceutical Sciences

Solid-state NMR spectroscopy: Principles and applications

F SEPAROVIC

Journal article  |  2002  |  Chemistry in Australia

Solid-state NMR structure determination of melittin in a lipid environment

YH Lam, SR Wassall, CJ Morton, R Smith, F Separovic

Journal article  |  2001  |  Biophysical Journal

Solid-state NMR study of aging of Colorbond polymer coating

F Separovic, HD Chau, MI Burgar

Journal article  |  2001  |  Polymer

Solid-state NMR relaxation studies of Australian spider silks

AI Kishore, ME Herberstein, CL Craig, F Separovic

Journal article  |  2001  |  Biopolymers

A metallosupramolecular capsule with the topology of the tetrahedron, 3(3), assembled from four guanidine-based ligands and twelve cadmium centers

IM Muller, R Robson, F Separovic

Journal article  |  2001  |  Angewandte Chemie - International Edition

A reexamination of the structure of "Honeycomb cadmium cyanide"

BF Abrahams, BF Hoskins, YH Lam, R Robson, F Separovic, P Woodberry

Journal article  |  2001  |  Journal of Solid State Chemistry

Biophysical studies of a transmembrane peptide derived from the T cell antigen receptor

M Ali, MRR De Planque, NT Huynh, N Manolios, F Separovic

Journal article  |  2001  |  Letters in Peptide Science

M Ali, MRR De Planque, NT Huynh, N Manolios, F Separovic

Journal article  |  2001  |  Letters in Peptide Science

Synthesis of deuterated aminocaproyl linkers

A Anastasiadis, F Separovic, J White

Journal article  |  2001  |  Australian Journal of Chemistry

Effect of avidin on channel kinetics of biotinylated gramicidin

TI Rokitskaya, YN Antonenko, EA Kotova, A Anastasiadis, F Separovic

Journal article  |  2000  |  Biochemistry

Orientation dependence of NMR relaxation time, T-1 rho, in lipid bilayers

F Separovic, B Cornell, R Pace

Journal article  |  2000  |  Chemistry and Physics of Lipids

Conformational studies of a melittin-inhibitor complex

YH Lam, V Nguyen, E Fakaris, F Separovic

Journal article  |  2000  |  Journal of Protein Chemistry

A P-31 NMR study of the interaction of amphibian antimicrobial peptides with the membranes of live bacteria

BCS Chia, YH Lam, M Dyall-Smith, F Separovic, JH Bowie

Journal article  |  2000  |  Letters in Peptide Science

Selective on-resonance NMR irradiation of a dipolar doublet

F Separovic, NR Skrynnikov, BC Sanctuary

Journal article  |  2000  |  Australian Journal of Chemistry

Gramicidin channel controversy - the structure in a lipid environment

OS Andersen, HJ Apell, E Bamberg, DD Busath, RE Koeppe, FJ Sigworth, G Szabo, DW Urry, A Woolley

Journal article  |  1999  |  Nature Structural Biology

Gramicidin channel controversy - revisited

TA Cross, A Arseniev, BA Cornell, JH Davis, JA Killian, RE Koeppe, LK Nicholson, F Separovic, BA Wallace

Journal article  |  1999  |  Nature Structural Biology

Determination of chemical shielding tensor of an indole carbon and application to tryptophan orientation of a membrane peptide

F Separovic, J Ashida, T Woolf, R Smith, T Terao

Journal article  |  1999  |  Chemical Physics Letters

Variable-temperature one- and two-dimensional C-13 CP/MAS NMR studies of the dynamics of monohaptocyclopentadienyl rings of hafnium and titanium tetracyclopentadienyl in the solid state

EJ Munson, MC Douskey, SM De Paul, M Ziegeweid, L Phillips, F Separovic, MS Davies, MJ Aroney

Journal article  |  1999  |  Journal of Organometallic Chemistry

NMR structure of C-terminally tagged gramicidin channels

F Separovic, S Barker, M Delahunty, R Smith

Journal article  |  1999  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

The interactions of the N-terminal fusogenic peptide of HIV-1 gp41 with neutral phospholipids

C Curtain, F Separovic, K Nielsen, D Craik, Y Zhong, A Kirkpatrick

Journal article  |  1999  |  European Biophysics Journal

A solid-state NMR study of protein hydration and stability

F Separovic, YH Lam, X Ke, HK Chan

Journal article  |  1998  |  Pharmaceutical Research

Optical modulation of the insertion of gramicidin into bilayer lipid membranes

P Osman, S Martin, D Milojevic, C Tansey, F Separovic

Journal article  |  1998  |  Langmuir

Biological NMR spectroscopy

Frances Separovic

Journal article  |  1998  |  Concepts in Magnetic Resonance

Effect of unsaturation on the chain order of phosphatidylcholines in a dioleoylphosphatidylethanolamine matrix

F Separovic, K Gawrisch

Journal article  |  1996  |  Biophysical Journal

Nuclear magnetic resonance investigation of hydrocarbon chain packing in bilayers of polyunsaturated phospholipids

LL Holte, F Separovic, K Gawrisch

Journal article  |  1996  |  Lipids

FUSOGENIC ACTIVITY OF AMINO-TERMINAL REGION OF HIV TYPE-1 NEF PROTEIN

CC CURTAIN, F SEPAROVIC, D RIVETT, A KIRKPATRICK, AJ WARING, LM GORDON, AA AZAD

Journal article  |  1994  |  AIDS Research and Human Retroviruses

SODIUM-ION BINDING IN THE GRAMICIDIN-A CHANNEL - SOLID-STATE NMR-STUDIES OF THE TRYPTOPHAN RESIDUES

F SEPAROVIC, J GEHRMANN, T MILNE, BA CORNELL, SY LIN, R SMITH

Journal article  |  1994  |  Biophysical Journal

STRUCTURE AND ORIENTATION OF THE PORE-FORMING PEPTIDE, MELITTIN, IN LIPID BILAYERS

R SMITH, F SEPAROVIC, TJ MILNE, A WHITTAKER, FM BENNETT, BA CORNELL, A MAKRIYANNIS

Journal article  |  1994  |  Journal of Molecular Biology

ZEEMAN-INCREMENTED MULTIPLE-QUANTUM NMR

GJ BOWDEN, MJ PRANDOLINI, JM POPE, F SEPAROVIC

Journal article  |  1993  |  Journal of Magnetic Resonance, Series A

NMR ORDER PARAMETER ANALYSIS OF A PEPTIDE PLANE ALIGNED IN A LYOTROPIC LIQUID-CRYSTAL

F SEPAROVIC, R PAX, B CORNELL

Journal article  |  1993  |  Molecular Physics

MELITTIN-INDUCED CHANGES IN LIPID MULTILAYERS - A SOLID-STATE NMR-STUDY

R SMITH, F SEPAROVIC, FC BENNETT, BA CORNELL

Journal article  |  1992  |  Biophysical Journal

C-13 CHEMICAL-SHIFT TENSOR OF L-TRYPTOPHAN AND ITS APPLICATION TO POLYPEPTIDE STRUCTURE DETERMINATION

F SEPAROVIC, K HAYAMIZU, R SMITH, BA CORNELL

Journal article  |  1991  |  Chemical Physics Letters

ACTIN DYNAMICS STUDIED BY SOLID-STATE NMR-SPECTROSCOPY

L PHILLIPS, F SEPAROVIC, BA CORNELL, JA BARDEN, CG DOSREMEDIOS

Journal article  |  1991  |  European Biophysics Journal

MOLECULAR SEQUENCE EFFECT ON THE C-13 CARBONYL CHEMICAL-SHIFT SHIELDING TENSOR

F SEPAROVIC, R SMITH, CS YANNONI, BA CORNELL

Journal article  |  1990  |  Journal of the American Chemical Society

SOLID-STATE C-13-NMR STUDIES OF THE EFFECTS OF SODIUM-IONS ON THE GRAMICIDIN-A ION CHANNEL

R SMITH, DE THOMAS, AR ATKINS, F SEPAROVIC, BA CORNELL

Journal article  |  1990  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

TENSORIAL SETS FOR COUPLED PAIRS OF SPIN-1/2 NUCLEI

GJ BOWDEN, JPD MARTIN, F SEPAROVIC

Journal article  |  1990  |  Molecular Physics

LOCALIZATION OF UBIQUINONE IN MEMBRANES BY NMR AND NEUTRON-DIFFRACTION

BA CORNELL, MA KENIRY, R KNOTT, A POST, RN ROBERTSON, F SEPAROVIC, LE WEIR, PW WESTERMAN

Conference Proceedings  |  1990  |  HIGHLIGHTS IN UBIQUINONE RESEARCH

EFFECT OF ACYL CHAIN-LENGTH ON THE STRUCTURE AND MOTION OF GRAMICIDIN-A IN LIPID BILAYERS

BA CORNELL, F SEPAROVIC, DE THOMAS, AR ATKINS, R SMITH

Journal article  |  1989  |  Biochimica et Biophysica Acta (BBA) - Biomembranes

DETERMINATION OF THE STRUCTURE OF A MEMBRANE-INCORPORATED ION CHANNEL - SOLID-STATE NUCLEAR MAGNETIC-RESONANCE STUDIES OF GRAMICIDIN-A

R SMITH, DE THOMAS, F SEPAROVIC, AR ATKINS, BA CORNELL

Journal article  |  1989  |  Biophysical Journal

MQ NMR HARD AND SOFT PULSES FOR I = 1 SPIN SYSTEMS - RAMAN MULTIPLE-QUANTUM NMR

GJ BOWDEN, WD HUTCHISON, F SEPAROVIC

Journal article  |  1988  |  Journal of Magnetic Resonance (1969)

EXCITATION OF TRIPLE QUANTUM NMR COHERENCES IN SOLIDS BY HARD RF PULSES

WD HUTCHISON, F SEPAROVIC, B CORNELL, GJ BOWDEN

Journal article  |  1988  |  Chemical Physics Letters

CHARACTERIZATION OF DODECYLPHOSPHOCHOLINE MYELIN BASIC-PROTEIN COMPLEXES

GL MENDZ, WJ MOORE, IJ KAPLIN, BA CORNELL, F SEPAROVIC, DJ MILLER, LR BROWN

Journal article  |  1988  |  Biochemistry

SIDE-CHAIN AND BACKBONE CONFORMATION OF GRAMICIDIN-A IN LIPID BILAYER-MEMBRANES

BA CORNELL, F SEPAROVIC, R SMITH

Conference Proceedings  |  1988  |  TRANSPORT THROUGH MEMBRANES : CARRIERS, CHANNELS AND PUMPS

THE EFFECT OF GRAMICIDIN-A ON PHOSPHOLIPID-BILAYERS

BA CORNELL, LE WEIR, F SEPAROVIC

Journal article  |  1988  |  European Biophysics Journal

A MODEL FOR GRAMICIDIN A'-PHOSPHOLIPID INTERACTIONS IN BILAYERS

BA CORNELL, F SEPAROVIC

Journal article  |  1988  |  European Biophysics Journal

CONFORMATION AND ORIENTATION OF GRAMICIDIN-A IN ORIENTED PHOSPHOLIPID-BILAYERS MEASURED BY SOLID-STATE C-13 NMR

BA CORNELL, F SEPAROVIC, AJ BALDASSI, R SMITH

Journal article  |  1988  |  Biophysical Journal